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Melatonin – Impressive Health Benefits | Life Extension …

New research indicates that melatonin does much more than help some people sleep better. Exciting studies show that melatonins multifaceted effects may improve treatment outcomes in cancer patients and extend their lives. Additional applications of melatonin include guarding the nervous system against degenerative diseasessuch as Alzheimers disease and strokeand preventing debilitating migraines.

Melatonin is secreted from the pineal gland deep inside the brain. For more than a quarter-century, scientists have been intrigued by melatonins ability to coordinate the bodys physiological rhythms that help set the brains biological clock.

The principal factor affecting melatonin is light, which inhibits the secretion of this hormone. Darkness has the opposite effect from light, resulting in signaling to the pineal gland to increase melatonin secretion. The normal cycles of melatonin production are altered due to factors including aging, medications, and light exposure at night. While the long-term health effects of disrupted melatonin secretion are not yet fully known, some scientists have suggested that years of working nights could lead to adverse effectseven cancer.

Fortunately, melatonin supplements can safely and effectively restore balance to the bodys circadian rhythm of this important hormonehelping achieve a restful nights sleep and keeping your biological clock ticking throughout a long, healthy life span.

Melatonin is a powerful and versatile antioxidant produced within the body. Melatonin protects both lipids and proteins against damage, and can scavenge some of the most dangerous free radicals in the bodyincluding hydroxyl radicals and hydrogen peroxide. Unlike other antioxidants, melatonin easily diffuses into all cells, and even crosses the blood-brain barrier to protect the delicate brain.1

Unfortunately, levels of naturally produced melatonin decline with advancing age, leaving older adults with limited antioxidant protection against conditions associated with oxidative stress, particularly neurodegenerative diseases.1 Supplementing with melatonin may thus help older adults enhance their antioxidant protection against some of the most ravaging diseases of aging, such as Alzheimers disease, Parkinsons disease, and stroke.

Melatonin levels are particularly low in patients with Alzheimers disease. Nearly half of affected individuals suffer from sleep disturbances and sundowningincreased confusion, agitation, and other symptoms in the afternoon and evening.2 Not surprisingly, melatonin supplementation benefits patients with Alzheimers disease by improving sleep and reducing late-day aggravation of symptoms. Melatonin has also been found to decrease cognitive deterioration in individuals with Alzheimers disease, possibly by protecting brain cells from the toxic protein, beta-amyloid.2

Melatonin may likewise play an important role in assisting patients suffering from Parkinsons disease. Parkinsons disease is associated with disrupted melatonin secretion in the brain, and supplemental melatonin may help improve sleep efficiency in affected adults.3

The brain can suffer dramatic, irreparable damage when an individual suffers a stroke. Utilizing animal models of stroke, scientists have found that melatonin may offer important protection against stroke-related damage and deterioration. When administered at the time of stroke, melatonin limited the area of brain tissue damage, decreased brain cell death, lessened behavioral deficits, and reduced the rate of stroke-related death. These investigators believe that melatonins protective actions stem from its free-radical-scavenging and antioxidant activities, and suggest that melatonin may hold promise in improving stroke outcomes in humans.4

Melatonin may help manage one of the leading risk factors for strokeelevated blood pressure. While an earlier study reported that hypertensive men taking melatonin experienced reduced nighttime blood pressure, a newer study confirms the same benefit for women.5 In a randomized, double-blind study, 18 women

(aged 47 to 63) with either normal blood pressure or treated high blood pressure received a three-week course of slow-release melatonin (3 mg) or placebo, one hour before bedtime. Researchers recorded blood pressure readings for 41 hours at the end of the trial. While the daytime blood pressure readings remained unchanged com-pared to placebo, the melatonin treatment significantly decreased nighttime blood pressure, without modifying heart rate.6

One of melatonins most important applications is in fighting a wide array of cancers, including breast and liver cancers, non-small-cell lung cancer, and brain metastases from solid tumors.7

When women with metastatic breast cancer who had failed to respond to tamoxifen received melatonin supplements (20 mg every evening), they demonstrated an improved response to the chemotherapy drug. More than one quarter of the subjectswhose disease otherwise was expected to progress rapidlybegan responding to the chemotherapy treatment. Most of the women also experienced anxiety relief from the melatonin supplementation.8 Laboratory studies suggest that melatonin may help fight hormone-responsive breast cancers by inhibiting the aromatase enzyme, which is responsible for the local synthesis of estrogens.9,10

Emerging research suggests that melatonin may help fight one of the most common malignancies in aging menprostate cancer. In the laboratory, scientists treated androgen-sensitive and androgen-insensitive prostate cancer cells with pharmacological concentrations of melatonin. Treatment with melatonin dramatically reduced the number of prostate cancer cells, while the remaining cells displayed signs of slowed replication and increased differentiationcharacteristics of healthy, non-cancerous cells. Melatonin may thus hold promise against prostate cancers, whether they are hormone-sensitive or hormone-insensitive.11

Scientists conducted a meta-analysis of 10 randomized, controlled trials examining melatonins effects (alone or as an adjuvant treatment) on patients with various types of cancer. Supplementation with melatonin reduced the relative risk of death at one year by an impressive 34%regardless of the type of cancer or the melatonin dosage. Importantly, no adverse effects were reported.12

In addition to its benefits for cancer survival, melatonin may also help counteract the toxicity of chemotherapy treatment. Two-hundred-fifty individuals undergoing chemotherapy for advanced cancers of the lung, breast, gastrointestinal tract, or head and neck received chemotherapy, either alone or in combination with melatonin (20 mg/day). After one year, the melatonin-supplemented individuals demonstrated a higher rate of survival, and were significantly protected against many of the side effects associated with chemotherapy, including decreased platelet count, neurotoxicity, heart damage, mouth sores, and fatigue.13

A promising study suggests that migraine sufferers may be able to reduce the frequency and severity of their headaches by using melatonin. Researchers gave 34 migraine sufferers (29 women and 5 men) a 3-mg dose of melatonin, 30 minutes before bedtime, for three months. Of the 32 patients who finished the study, more than two thirds experienced at least a 50% reduction in number of headaches per month. Additionally, the intensity and duration of headaches decreased. The scientists believe that melatonins anti-inflammatory effect and free-radical-scavenging effects contribute to its headache-relieving benefits.14

Obtaining sufficient amounts of quality sleep is an absolute necessity for good health, yet many of us experience sleep difficulties on occasion. Insomnia occurs due to a variety of factorsranging from long hours of work or travel to sleep-disruptive conditions, such as urinary frequency and stressful events. Elderly adults may be particularly susceptible to difficulty sleeping and nighttime awakenings, due to the decline in melatonin levels associated with aging.15 Melatonin can help promote healthy sleep patterns in some people, regardless of the cause of insomnia.

A large analysis revealed several of melatonins sleep-enhancing benefits. Reviewing 15 studies of sleep in healthy adults, scientists noted that melatonin administration significantly reduced sleep latency (the amount of time needed to fall asleep), while boosting sleep efficiency (the percentage of time in bed spent asleep) and increasing total sleep duration.16

Men with benign prostatic enlargement often experience poor sleep due to nighttime urinary frequency. Scientists from the United Kingdom found that melatonin may offer an effective solution. When 20 older men were treated with 2 mg of melatonin each day for one month, they experienced a significant decrease in nighttime urination, and reported that their condition was less bothersome than before treatment.15

Individuals who work the night shift are often chronically tired due to difficulty falling asleep during the daytime. Supplementing with melatonin has helped improve the length and quality of daytime sleep in these individuals. These findings demonstrate an important characteristic of melatonin: the hormone exerts its hypnotic (sleep-inducing) and sedative (anxiety-relieving) effects, regardless of dosage time.7

Traveling to different time zones often leads to the fatigue and insomnia known as jet lag. Supplementing with melatonin can help prevent or reduce jet lag, particularly when traveling across several time zones. Melatonin works by helping re-synchronize the bodys circadian rhythms, helping the traveler adapt to the local time.7

Melatonin is used in doses ranging from 0.3-5.0 mg to promote sleep, with doses of 1-3 mg most common.17 Studies examining melatonins effects on cancer have utilized doses of 3-50 mg/day.7

Melatonin has a sedating effect, which may be magnified by the use of benzodiazepines or other sedating drugs such as antihistamines or antidepressants. Similarly, the use of melatonin with valerian, 5-hydroxytryptophan, or alcohol may increase sedation.17

The bioavailability of oral melatonin is increased by co-administration of the antidepressant drug fluvoxamine (Luvox).17 Beta blockers, as well as aspirin and other non-steroidal anti-inflammatory drugs, may decrease melatonin production in the body.17

A factor in restorative sleep, melatonins benefits extend to neuroprotection and fighting cancer. Its powerful antioxidant effect offers important enhancements to the brain and nervous system, helping protect against age-related damage. Most exciting are melatonins benefits for cancer patientsrelieving anxiety and improving survival from an array of cancers. Finally, migraine sufferers using melatonin may enjoy a vast decline in the frequency and severity of their headachesleading to a tremendously improved quality of life.

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Melatonin – Impressive Health Benefits | Life Extension …

Relief of Overactive Bladder – page 1 | Life Extension …

A common and frustrating complaint we at Life Extension hear is how to stop urinary incontinence.

Our frustration has been that despite aggressive research, we could not identify a safe solution to this problem that plagues so many aging women (and men to a lesser extent).

Even more numerous are inquiries we receive from people seeking relief from frequent daytime and nighttime urinary urges.

In a breakthrough discovered by Japanese scientists, a natural plant extract combination has been shown to reduce incontinent episodes by up to 79%,1 daytime urination by up to 39%,2 and nighttime urination by up to 68%.3

This article will discuss the research findings on maturing women who found significant relief after taking this novel supplement for only six to eight weeks.

Additionally, this article will discuss more limited data obtained when men suffering from nighttime urinary urgencies were given this same plant extract.

Urinary frequency becomes more common with advancing age, with nearly half of people over 60 reporting to suffer from nocturia (two or more episodes of urination during the night).

Urinary incontinence is defined as an involuntary loss of urine. It represents a major social and hygiene problem in the aging population. About 48% of women and 17% of men over age 70 suffer urinary incontinence.4

Overactive bladder affects one in six adults over age 40, and is defined as having an urgent need to empty the bladder during the day-night, along with incontinence. Those afflicted with an overactive bladder have to go to the bathroom frequently, leak urine into their clothes, and report feeling depressed, stressed, and sleep-deprived.

In women, stress incontinence (involuntary loss of urine during physical activity such as sneezing or exercise) is usually caused by a weakening of the bladder sphincter and pelvic floor muscles. Shrinkage (atrophy) of tissues where the bladder and urethra meet also contributes to the problem. Hormonal changes occurring after menopause are thought to be an underlying cause of these anatomical changes in the bladder sphincter that lead to urinary incontinence.

In postmenopausal women, decreased androgen (testosterone) levels weaken the pelvic floor and sphincter muscles, while an estrogen deficit induces atrophy of the urethra.

Mainstream medicine offers only mediocre therapies to address urinary incontinence. Drugs commonly used for this condition are expensive and side-effect-prone. Only a small proportion of the affected population seeks treatment because most people consider their urinary symptoms a consequence of normal aging.

Fortunately, a safe, natural, and low-cost approach has been developed that has demonstrated remarkable benefits in human clinical trials.

Pumpkin seeds were traditionally used by Native American tribes to facilitate passage of urine. A European herbal encyclopedia first mentioned the use of pumpkins seeds to treat urinary problems in the year 1578. The German health regulators approve pumpkin seed as a treatment for irritable bladder.

Pumpkin seed oil has been included in products used to alleviate urinary difficulties. While some effects have been shown when using the fat-soluble (oil) fraction of the pumpkin seed, it is the water-soluble portion that demonstrated impressive symptomatic effects in recent studies.

Japanese scientists have patented a method to obtain the water-soluble constituents of the pumpkin seed, which are absorbed far more efficiently into the bloodstream.

Urinary incontinence worsens after menopause. While menopausal problems are usually associated with estrogen deficit, low levels of testosterone and progesterone are also underlying culprits.

Water-soluble pumpkin seed extract exerts an anabolic (tissue-building) effect on the pelvic floor muscles via several mechanisms. By inhibiting the aromatase enzyme, it may make more testosterone available to strengthen the pelvic muscles.5

Secondly, this water-soluble pumpkin seed fraction binds to the androgen receptor on pelvic muscle cells, thus inducing a strengthening effect. This is important because androgen receptors are expressed in the pelvic floor and lower urinary tract in humans.6 By promoting androgenic activity, water-soluble pumpkin seed extract may play an important role in female pelvic floor structural integrity and lower urinary tract disorders.5

Nitric oxide is a molecule critically involved in lower urinary tract functions. For the urination muscles to relax when the bladder is full, nitric oxide is required. When nitric oxide synthesis is inhibited, the result is bladder hyperactivity and reduced bladder volume.

The dual mechanisms of strengthening pelvic floor muscles, while increasing nitric oxide synthesis,5 help explain how water-soluble pumpkin seed extract alleviated urinary incontinence in three separate studies on aging women.1-3

Soy extracts provide standardized phyoestrogens that are potentially effective in ameliorating geriatric symptoms relating to estrogen deficit.

The ingestion of standardized soy extract has been hypothesized to decrease the atrophy of tissues where the bladder and urethra meet and thus alleviate frequent urinary urges and incontinence.

A study was done to evaluate the effects of water-soluble pumpkin seed extract in anesthetized rats to determine bladder functionality.7

As measured by a cystometrogram, bladder parameters showed a dramatic 54.5% improvement in rats receiving water-soluble pumpkin extract compared to other agents.

When the excretion frequency was measured, a 60% reduction in urine excretion frequency occurred after administration of water-soluble pumpkin seed extract. No improvement was seen in the group given inactive solvent.

Conclusions from the study showed that water-soluble pumpkin extract significantly increases maximum bladder capacity while decreasing urination frequency.

A study of 39 incontinent females (aged 55-79 years) using water-soluble pumpkin seed and soy isoflavone extracts was conducted over a six-week period.1 The objective was to evaluate the effects on frequency of daytime and nighttime urinations and number of incontinent episodes.

After six weeks, the number of nighttime urinations was reduced from 3.3 to 2.0 a 39% improvement. Daytime urinations went from 8.0 to 6.7 after six weeks a modest 16% improvement.

The number of incontinent episodes, however, plunged to a remarkably low number. Prior to receiving the water-soluble pumpkin seed-soy extract, these women experienced an average of 7.3 incontinent episodes a day. After six weeks of using this supplement, daily incontinent episodes averaged only 1.5 an astounding 79% decrease in urinary incontinence!

When these women were questioned about the effects they noticed in response to taking water-soluble pumpkin seed-soy extract, there was a 73% subjective improvement in the highest fulfilled category. When the global improvement ratio was evaluated, which included degree of satisfaction after sleeping, 81.8% of women with two to four episodes of nightly urinations reported that they were markedly improved.

A study of 50 incontinent women (aged 35-84 years) was conducted using the same water-soluble pumpkin seed-soy extract supplement to evaluate the effect on stress incontinence episodes.3

Before the pumpkin seed-soy supplement was given, these women averaged 2.1 incontinent events each day. After taking the supplement for six weeks, incontinent events fell to an average of only 0.7 a day a remarkable 67% decrease in stress-induced incontinent episodes!

A consumer test of 10 women (aged 45-65 years) was conducted using the same water-soluble pumpkin seed and soy extract supplement.2

After eight weeks, daytime urinations went from 9.3 to 5.6 a 39% reduction. Nighttime urinations went from 2.0 to 0.8 a 60% reduction.

Prior to initiating the pumpkin seed-soy supplement, there was an average of 2.3 incontinent episodes each day. After eight weeks, the frequency of incontinent episodes declined to only 1.0 per day a 57% reduction!

Link:
Relief of Overactive Bladder – page 1 | Life Extension …

Kariba project 92pc complete – The Herald

Dr Undenge

From Walter Nyamukondiwa in KARIBAThe Kariba South Extension Project is now 92 percent complete and on course for commissioning by end of December as Government moves to clear the power deficit.

This is part of an eight-pronged approach to increasing power generation amid indications that about $500 million is being mobilised for the Hwange Life Extension project.

With a daily deficit of between 300MW and 600MW, the shortfall is being reduced progressively.In an interview on the sidelines of the Zimbabwe Institute of Engineers biennial congress here yesterday, Energy and Power Development Minister Dr Samuel Undenge hailed the collaboration between the contractors and Zesa management.

We are very pleased with the progress so far and to date we know that the Kariba South Extension Project is now 92 percent complete and everything is on course for its commissioning on 24 December, 2017, said Dr Undenge.

We applaud the focused work and effort that is being exhibited by the contractor (Sinohydro) and Zesa management that has seen so much progress.

He said initial challenges of foreign currency to pay suppliers were being overcome with the involvement of the Reserve Bank of Zimbabwe. The two new units will add a further 300MW to the national grid.

Zimbabwe has not had load-shedding for the last 20 months, as more than 300MW are being imported to offset the supply deficit.Expansion works and implementation of new projects ties in with regional efforts within SADC to offset the 8 247MW deficit.

This is largely due to lack of meaningful investment in power generation over the last two decades.Zimbabwes major investment in the power sector was in 1987 when Hwange Stage II was commissioned.

Dr Undenge said load-shedding is a major cost and inconvenience to consumers, undermines economic growth and suppresses foreign and local investment.The Hwange Life Extension seeks to recondition the power plant and add another 25 years to its productive life.

There are also plans to increase the thermal plants generation capacity from 550MW to 750MW.Government is implementing eight strategies including optimising existing generation plants, development of renewable energy and conservation among others.

This also includes guaranteeing production at Harare II and III (40MW), Bulawayo (25MW) and Munyati (30MW) thermal power stations.The Energy minister revealed that tendering for the Batoka Gorge South Bank which will add a further 1 400MW to the national grid will be out soon.

In terms of the Batoka Gorge project there are feasibility studies that have just been completed, then tenders will be send out. So that process is underway, said the Minister.

Other projects in the pipeline include the Devils Gorge (1 000MW), Hwange Western Area (1 200MW), Tokwe-Mukosi Hydro (15MW) and Gairezi Small Hydro (30MW).

Dr Undenge said the Minister of Finance and Economic Development Patrick Chinamasa was working on incentives to make investment into the energy sector attractive.

The Minister (Chinamasa) is trying to come up with a regime of incentives so that we make investment into the energy sector by private players more attractive. We need them to augment what Government is doing, said Minister Undenge.

Originally posted here:
Kariba project 92pc complete – The Herald

Biopower in the Era of Biotech – lareviewofbooks

SEPTEMBER 7, 2017

TWO TRENDS are on the rise, and one is about to make the other worse.

The first is epitomized in a July 2017 report in The Economist on the United Statess urban-rural divide, which noted that deaths of despair suicide, heart disease, and drug overdoses are increasing in the southeastern corner of West Virginia. Life expectancy for men is now 16.5 years lower than in neighboring Arlington. Christian H. Coopers moving essay in Nautilus entitled Why Poverty Is Like a Disease, Karin Goodwins journalism in the Guardian, and James Bloodworths op-ed in New Scientist have piled on additional accounts of how chronic stress and loss of a sense of control can be our undoing.

Meanwhile, in the second trend, biotechs rise, ever more powerful tools are being developed for in vitro fertilization, and for anti-aging and cancer technologies. Some of the latter run to six figures, which means some insurance companies may not cover them.

As economist Thomas Piketty noted in 2014, and so many have since Trumps election, the United States is embroiled in an intensifying era of class struggle, which expresses itself not only in differential impacts on health as pegged to class, but also in the growing unlikelihood that the rural poor, and indeed the poor in general, can securely provide for their children, no doubt a factor in the declining fertility rate. At the same time, the commercialization of science steadily escalates, along with its corollary: the commercialization of human life. Many life scientists hope to start a company and strike it rich. Many have. Entrepreneurial scientists now count themselves among the wealthiest of Americans, and, as the market so freely allows, some of them build their careers on the development and sale of biotech solutions. Offering a route to positive eugenics, longer life, and interventions into deadly diseases, these life-saving and life-enhancing technologies will assuredly widen the public health gap.

First, consider birth. In December 2015, I attended a meeting at the National Academy of Sciences in which a member of the American Society of Reproductive Medicine stood up to proclaim that parents have a right to use the gene-editing tool CRISPR-Cas9 and in vitro, or IVF, technologies to have a genetically connected child. These technologies could be used, he explained, to repair the code for deleterious genes that run in certain families or improve older parents chances of a birth. Bioethicist Hille Haker argued that there is a difference between a negative right, which is a freedom from harm or tyranny, and a full positive right, which is a freedom to access potential benefits. Having a healthy child is a negative right, according to Haker, meaning a right you have unless someone (such as the Chinese government) takes it away, but not a full positive right. If it were a full positive right, society would be hidebound in debt to pay for each of its citizens to have children, applying genetic tests and in vitro techniques as needed. Almost no one would contend that society has such a responsibility, she argued. You may disagree with me, but as an ethicist I put the consequential assessment in terms of rights and obligations, Haker said. There is no right to a genetically related child, it is a high value, not a right.

In August, Shoukhrat Mitalipov, at the Oregon Health & Science University in Portland,controversially became the first scientist in the United States to use the gene modification system CRISPR to alter a human embryo. He modified the gene MYBPC3; when mutated in a single copy of that gene, it can increase your risk for a rare heart condition. Forty-two of the 58 embryos he altered, or 72 percent, had two mutation-free copies of the gene in every cell, and, most importantly, there were no unintended mutations. This study suggests that any technical limitations will soon be overcome, which will then open up a landslide of ethical questions related to equity. Keep in mind that many of us carry a genetic variant that predicts risk for a serious condition. Will insurance companies pay for these gene modifications, and to what extent? Or will the wealthy alone be able to afford to modify their embryos?

This past winter, the National Academy of Sciences and National Academy of Medicine published a report entitled Human Genome Editing: Science, Ethics, and Governance that signals support for gene editing to the heritable, or germline, code, but only in cases where no safer options are available. In her book, A Crack in Creation, Jennifer Doudna, one of the inventors of CRISPR-Cas9, also signaled her openness to CRISPR-ized babies through gene modification.

Already, insurance coverage of in vitro fertilization varies widely by state, and now gene modification techniques may further challenge the concept of what is medically necessary. A mutated APP gene can predict early-onset Alzheimers. A mutated BRCA gene can predict breast or ovarian cancer. A disrupted PCSK9 can lower LDL cholesterol. The Food and Drug Administration actually thinks of CRISPR as a drug rather than a device, so in the United States, CRISPR must pass through a regulatory process for each target it modifies, even in an embryo. For some single-gene or Mendelian diseases such as Tay-Sachs and cystic fibrosis, or the immune disorders NEMO or X-SCID, CRISPR technology could be a fairly straightforward new treatment modality in vitro. Keep in mind, however, that generating an embryo without a heritable mutation can, in the vast majority of cases, already be accomplished by screening embryos before implantation. This raises the question of when CRISPR would be indispensable. In fact, genetic variants in BRCA, which tend to run in high-risk families, are nested in complex so-called epistatic relationships involving the interaction of multiple genetic variants. It would be impossible to know whether altering that single gene reduces cancer in a family in future generations. And if it did, would poor families be able to afford it? Probably not.

Marcy Darnovsky, director of the Center for Genetics and Society in Berkeley, California,and her team have counted as many as 45 countries that ban germline modification. The United States is not one of them, and instead it handles germline editing in vitro much as it does stem cell research by prohibiting funding to scientists to do this research and prohibiting funding to the FDA to review applications for clinical trials of CRISPR babies. We can be sure that entrepreneurial scientists who stand to cash in on such technologies are working to alter such policies. Using gene-editing techniques in a test tube is arguably safer than using gene modification techniques on a living person in a test tube, youre modifying a clump of 64 cells or fewer, rather than trillions of cells, and eliminating the risk of an immune reaction. But those test tube techniques still require genetic diagnostics to know something about a familys risk, not to mention requiring the capital outlay to pay for expensive genetic diagnosis and IVF treatments in short, not particularly realistic or affordable for most of us.

Ultimately, none of this would help living people who develop a disease such as cancer. New technologies such as genetically engineered T-cells combined with CRISPR will enable doctors to coax the bodys immune system into fighting cancer,the first of which wasapprovedonAugust 30, which Novartis will sell in the U.S. for$475,000, a drug price that is nine times the median income in the United States. This means that high-cost medicines will create wealthy scientists and just as surely will exacerbate the health divide. This may be the reality if the Trump administration repeals the Affordable Care Act, but it may also be the reality in a single-payer system such as the National Health Service in Britain, which isnt prepared to pay for these high-priced medicines either. Indeed, oncologist and author Siddhartha Mukherjee warned this summer at the annual American Society of Clinical Oncology meeting about dividing the world into the rich who can afford personalized cancer treatment and the poor who cannot. If health insurance is unequal or inadequate, the only solution may be to use the power of the state to regulate the cost of cancer drugs. A drug price fairness initiative is in fact already on the ballot in Ohio; and transparency laws, established in Vermont, are clarifying their cost. We may have to cap them by executive order.

In the 1970s, Michel Foucault developed the influential notions of biopower and biopolitics, which gave power its access even to the body. In his words, biopolitics is the endeavour, begun in the eighteenth century, to rationalize problems presented to governmental practice by the phenomena characteristic of a group of living human beings constituted as a population: health, sanitation, birth rate, longevity, race. He defines biopower as the techniques for achieving the subjugation of bodies and the control of populations. But even Foucault had yet to conceive of how new biotechnologies could be leveraged. The industrial revolution of the human genome initiates an era in which social divisions are amplified by means of genomics technologies.

Foucault was wrong about some things, such as health and mental illness being solely the result of social forces. But he may have been only partially wrong. As neuroscientist Robert Sapolsky and so many others have noted, stress is distributed unequally across the social spectrum. Hierarchies of wealth and power institutionalize certain forms of stress, including chronic forms, and, according to a spate of recent research, social hierarchies are then embedded in body chemistry through social imprinting. If this research holds up, then it seems clear that we cant undo the damages accrued by years of poverty or poor social status by giving more funding to wealthy scientists. Theres been a clear shift to funding genetics research into mental illness, but the fact is that this research supports the drug-maker model, which then mostly benefits those who control and sell those drugs. It supports their careers through generous amounts of public funding. It does not support the disenfranchised who may need more than drug-based interventions.

The philosopher Nick Bostrom defines transhumanism as the doctrine that

holds that current human nature is improvable through the use of applied science and other rational methods, which may make it possible to increase human health-span, extend our intellectual and physical capacities, and give us increased control over our own mental states and moods.

This not-so-subtle movement includes efforts by the National Institute of Mental Health to monetize the field of psychiatry by basing research on a molecular biomarker or gene target that can be pursued as a diagnostic test or drug target, an agenda that is, in fact, now in retreat because so few reliable biomarkers or targets have actually been discovered. Clinical biomarkers and biochemical transformations have failed to make a dent in suicide rates, not to mention in the incident rates or prognosis of serious psychiatric ills. The most promising discovery coming out of research into psychiatric drugs in recent years may be a street drug called ketamine, or Special K, a worldly knowledge that experts have expropriated from regular folks.

As for the budding life-extension industry, it is built around over-the-counter drugs, such as nicotinamide mononucleotide (NMN), and the development of new drugs to degrade proteins that build up in brains and are associated with age-related diseases such as Alzheimers and Parkinsons disease. In 2013, the Time magazine cover story Can Google Solve Death? became part of the transhumanist spectacle when it noted that, for CEO Larry Page, solving cancer may not be a big enough task. The article introduced life extension company Calico, which is currently working on ways to degrade proteins that build up in the brain and are correlated with age-related diseases. But insurers may not have an incentive to pay for life-extension techniques that add bonus years, since insurance is more costly when we are older. As a result, these pursuits only contribute to the trope that life extension is a luxury pursued by wealthy Silicon Valley entrepreneurs stymied by their own loss of control. The most potent real news is precisely the connection between income and longevity. In short: The fact that such studies have led to no major societal shifts in how we value life suggests that the longevity that drug makers pursue as a financial prospect is solely about extending life for the wealthy.

An urgent question, therefore, is the following: Are our scientific institutions working on behalf of the public and fairness, and so of distributive justice, or are they working for commercial interests? And another disturbing question: Are these interests being normalized before we can even debate them? The fact that scientists themselves like to appeal to economic interests when asking for public funding should offer one clue. And of course it doesnt help that scientists want to sell us stuff.

In the famous 1971 Chomsky-Foucault Debate, Foucault argued that those who take up social justice causes are in fact doing so only because they want to take power. Chomsky demurred:

I think its too hasty to characterize our existing systems of justice as merely systems of class oppression [] they also embody a kind of groping towards the true humanly valuable concepts of justice and decency and love and kindness and sympathy, which I think are real.

Of course, institutions can be applied to advance justice and fairness, or be exploited for special interests. If authority is broadly distributed and innate to the wellsprings of the mind, then institutions are an extension of principles that reside within us and should seek to ensure access and fairness. But if scientists are working toward selling biotech solutions at the highest price the market will allow, then scientific institutions may be exploited for power and profit and thats just capitalism.

The irony is that we may need the state to ensure fair access to medicines we fund, and to prohibit genetic enhancement or reproductive advantages if all of us cant afford or access them. This is no small problem. Political scientist Francis Fukuyama called transhumanism the worlds most dangerous idea, suggesting that the commercialization of biotech would create increasing unfairness. In his book Our Posthuman Future, he qualifies his original end of history thesis, arguing that human genetic engineering and in vitro fertilization might perpetuate social divisions, putting liberal democracy at risk. If there is one imperial power left on the world stage, Fukuyama argues, it is biotech. What should we do in response to biotechnology that in the future will mix great potential benefits with threats that are either physical and overt or spiritual and subtle? he asks. The answer is obvious: We should use the power of the state to regulate it.

Here are some recommendations: the price of biologic medicines (gene and cell therapies) should be fixed or capped that is, if the public is expected to subsidize their cost through National Institutes of Health funding. If that sounds too much like socialism, then we need to stop socializing the costs and risks of drug development through NIH funding. A second point: The federal legislators and the FDA should have strong regulatory control over the creation of gene modifications to the heritable code of newborns. For the moment, they are able to constrain those enterprises as mentioned earlier, the FDA regulates gene modifications as a drug, and any specific target must pass through an extensive regulatory process. Once approved, then some sort of public insurance must make them accessible to everyone, or else biotech will assuredly exacerbate social and economic inequality, thus affecting the Freedom Index in the United States.

Scientists are readily using taxpayer funding to advance their own economic interests, thereby institutionalizing power and wealth. Indeed, many managerial scientists count themselves among the wealthiest Americans with annual salaries in the six and seven figures. If the state has a role, it is to live up to the ideals which we are groping towards, the concepts of justice and decency, rather than the current reality of scientific institutions seeding biotech startups. The fact is that scientists are increasingly testing public trust. Whether they should continue to receive tax-exempt funding ought to depend on whether they are working toward fair and equal access to medicine, lest by the time science funding reaches a commercial shelf, life is simply up for sale.

Jim Kozubek is the author ofModern Prometheus: Editing the Human Genome withCrispr-Cas9,published by the Cambridge University Press.

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Biopower in the Era of Biotech – lareviewofbooks

Beware of the Overstated Service Life in the Cost Approach – Lexology (registration)

The cost approach requires the identity and quantification of three types of obsolescence physical, functional and economic. Assessors frequently account only for physical depreciation (although some assessors/appraisers apply a special factor in an attempt to capture functional and economic obsolescence). Physical depreciation is dependent upon accurately determining: (1) the effective age, which is the chronological age or the weighted chronological age (if physical improvements have been made) adjusted for physical condition; and (2) the appropriate service life of the facility (some also measure and apply remaining life). Needless to say, an assessor/appraiser can increase a propertys value by misstating any one of these factors. So, the taxpayer must closely review the assessment process to make sure that each factor reflects market realities and the facilitys physical condition. It is also essential that the assessor/appraiser apply an appropriate service life that considers the major components of the facility and their interaction on the life of the facility. A purchaser of the building only recognizes value to the extent that the building can continue to produce profitable net operating income at a required rate of return. An example is an old K Mart or Sears building. Physically, for retail purposes, they are likely to have short term life, as major reparations are likely necessary to make the facilities operable in todays demanding retail environment. Nonetheless, taxing jurisdictions often apply longer physical lives that are based on the effect of such reparations (i.e., life extension); even though, they have not yet been incurred and without accounting for their cost. This artificially boosts the facilitys valuation.

Bottom line, if the taxpayer does not accurately identify and quantify the physical age, condition and service life, its property will continue to be over valued by the assessor/appraiser. If economic life is applied, the appraiser needs to recognize and quantify the other non-physical forms of obsolescence captured in the economic life to avoid double counting.

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Beware of the Overstated Service Life in the Cost Approach – Lexology (registration)

‘America’s Tall Ship’ – Virginia Connection Newspapers

The U.S. Coast Guard Cutter Eagle moors at Point Lumley Park in Old Town Sept. 4, marking the first time in 11 years that the vessel known as Americas Tall Ship returned to the Washington area.

Alexandria For the first time in 11 years, the U.S. Coast Guard Cutter Eagle arrived in the

Washington area, mooring at Old Towns Point Lumley Park Sept. 4 as part of the tall ships summer deployment.

Also known as Americas Tall Ship, Eagle is the largest tall ship flying the U.S. flag and the only active commissioned sailing vessel in American military service. Eagle is the only square-rigger in the U.S. military services and is used to train students at the U.S. Coast Guard Academy in New London, Conn.

The Eagle has a fascinating history, said Old Town resident Hal Hardaway after touring the vessel Sept. 5. Eagle was hull #508 built in the Blohm and Voss shipyard in Hamburg in 1936. That yards next hull # 509 was Bismark.

Alexandria is Eagle’s final stop in its summer deployment, which has spanned

five months and included 14 ports, including multiple ports along the Eastern Seaboard, Canada and Bermuda.

Also known as the Coast Guard Barque Eagle, the ship left Baltimore April 26 bound for New London to commence the 2017 cadet summer training program. Eagle and her crew, including Capt. Matthew Meilstrup as commanding officer, have been at the Coast Guard Yard facility in Baltimore as part of a Service Life Extension Project that will keep the ship away from its home port of New London for several years.

The ship was built in 1936 in Germany and commissioned as Horst Wessel, one of three sail training ships operated by the pre-World War II German navy. At the close of World War II, Horst Wessel was taken as a war reparation by the United States, recommissioned as the U.S. Coast Guard Cutter Eagle and sailed to New London. The vessel is used for at-sea leadership and professional development training for future officers of the U.S. Coast Guard.

Eagle is scheduled to depart Point Lumley at approximately 4:30 a.m. Sept. 8. The Woodrow Wilson Bridge span will be raised at that time to allow Eagle to sail through as it makes its return to Baltimore.

For more information, visit http://www.cga.edu/eagle.

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‘America’s Tall Ship’ – Virginia Connection Newspapers

Want To Live Longer? Life Extension Drugs On Horizon; How They Work – Medical Daily

Imagine taking a pill that couldextend your lifespan. This plotline exists in the pages of science fiction novels, but a class of drugthat supports healthy aging, known as a senolytic drug, is currentlybeing tested, and if proven safe, could do more than add years to your life.A new studywhich showed the drugs preventedage-related bone loss in micehas important implications in treating a host of other diseases related to aging, researchers said.

Cells constantly divide, a process that allows us to grow and heal, but as we age, some cellsstop dividingand become senescent. These cellsalsoemit toxins that contribute to a number of health conditions such as cancer, dementia, and arthritis. The older we are, the more of these senescent cells we accumulate. Enter senolytic drugs.

These drugs are designed toclearaway senescentcells while leaving adjacentcells unharmed. According to the research,published online in Nature Medicine, these drugssupported healthy aging in mice and prevented bone loss. Considering that clearing senescent cells improves cardiovascular function and reduces frailty and other issues, this treatment could have important implications for treating not only osteoporosis, but other age-related problems, the authors wrote.

In a related article, the authors alsodescribea new screening platform to better identifyother potential senolytic drugs, which would help us address age-related conditions as a group, instead of one at a time.

“The emerging repertoire of senolytic drugs shows that they are having an impact on a huge range of diseases,” said study researcher Dr. James Kirkland in a recent statement. “Our goal is to achieve the same success in humans as we have in preclinical animal models in efforts to prevent or delay the conditions associated with aging.”

Moving forward, the researchers would like to further explore the potential of these drugs and figure out optimal drugcombinations forthe best results. Though”median lifespan” or “healthspan” aredifficult endpoints to determine in research,animal trials have given us a good idea of the drugs’ potential therapeutic benefits.

This week has been exciting for the study of human aging and lifespan, as a recent Dutch article claimed to have found the maximum human lifespan:115.7 for women, and 114.1 for men, IFL Science reported. This number is based off a study of 75,000 now-deceased Dutch people, and while the researchers admit that people on average are living longer than before, this ceiling age still remains unchanged.

The research is controversial, with some researchers arguing thatit is possible to live beyond these ages, although rare.

The evidence points towards no looming limit. At present the balance of the evidence suggests that if there is a limit it is above 120, perhaps much above and perhaps there is not a limit at all,Jim Vaupel, a specialist in aging at the Max Planck Institute for Demographic Research in Germany, who wrote a paper criticizing these results, told The Guardian.

Regardless of what the ultimate age may be (or if it even exists), its still exciting that something as simple as a pill mayhelp us reach it. The senolytic drugs still need to be tested in human clinical trials, but according to CNN, it may be time to take that leap.

Source: Farr JN, Xu M, Weivoda MM, et al. Targeting cellular senescence prevents age-related bone loss in mice. Nature Medicine . 2017

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Want To Live Longer? Life Extension Drugs On Horizon; How They Work – Medical Daily

Want to Age Better? Look to Your Cells – The Good Men Project (blog)

This is paid content as part of a partnership between The Good Men Project and ChromaDex.

Do you feel yourself slowing down recently? Over time, sun exposure, excessive food and alcohol consumption, and jetting between time zones are just a few factors that can depress your metabolism and cellular health.

There is a clinically-studied vitamin that can help reduce the effects of aging and help your cells function like they did when they were younger. Is your metabolism missing this crucial component?

Men and women in their 40s and beyond are turning to a form of vitamin B3 called nicotinamide riboside (NR) to defend against the adverse effects of slowing metabolism.

Dr. Charles Brenner, the Roy J. Carver Chair of Biochemistry at the University of Iowa and the founding co-director of the University of Iowa Obesity Initiative, is responsible for discovering the link between NR and a co-enzyme called NAD+, which is a crucial key to human health.

Dr. Brenner is also the Chief Scientific Advisor behind TRU NIAGEN, the only NR supplement directly from the ingredients patent-holder.

We invite you to read our Q&A with Dr. Brenner to learn more about his discovery, cellular health and why NR should be part of your morning routine.

GMP: What is NR and why do people take it?

CB: NR is a vitamin that maintains and boosts the central regulator of metabolism: NAD+.

NAD+ is required for us to convert our fuels (fats, proteins, and carbohydrates) into the energy we need to move, think and stay in optimal health. NAD+ is also required to protect our DNA and maintain nerve and muscle function.

Levels of NAD+ naturally decline with age. In addition, our levels of NAD+ are challenged by many metabolic stresses including sun and alcohol exposure, toxins, overeating and jetting between time zones. People take NR to maintain their youthful metabolism and resilience as we age and experience stress.

What kind of results can one expect to see from taking NR and in what time period?

People who have started taking TRU NIAGEN report subtle changes in their overall feelings of well-being including improved sleep, consistent energy, improved mental clarity and alertness, and improved skin and digestive health within 2 to 4 weeks of taking their first dose.

Can you describe the best candidates for NR supplementation?

NR is not intended to treat any disease or condition. NR is for adults, and given a reduction of NAD+ with age, will likely benefit those age 40 and above more than younger people. NR is not a substitute for a bad diet or poor sleep and hygiene, but it helps to optimize health and smooth out some of the stressors in life.

Is there anyone who shouldnt consider taking NR?

NR is not contraindicated for any conditions. However, we recommend that you talk to your about NR if you have a disease or any concerns at all.

Does NR have common side effects?

Based on clinical studies, there are no known side effects of NR. This is very different from another, commonly known form of vitamin B3 called niacin, which notoriously causes the uncomfortable side effect called flushing (reddening of the skin, often accompanied by a burning or itching sensation).

What kind of studies have been done with NR to prove its efficacy?

In people, weve shown that NR safely boosts NAD+ levels in a dose-dependent manner. Many more human studies are in process with some nearing publication.

Without getting too technical, how does NR impact longevity?

Well start by taking a deep breath and assure you we will not make human longevity claims. We have no plans specifically to test NR as a life extension supplement in people, but rather, a health extension supplement. Its reasonable to consider that by boosting NAD+, NR can help people age better, increasing many functional metrics of living that are collectively termed healthspan.

What is the number one reason someone would consider supplementing with TRU NIAGEN?

It is nutritional support for healthy aging. Of course, you should also eat right, and stay physically and mentally active.

Learn more about TRU NIAGEN today.

ChromaDex, the worldwide patent-holder of NIAGEN (nicotinamide riboside), previously only sold NR to third-party brands, but recently made NR available directly to consumers under the brand name TRU NIAGEN. With TRU NIAGEN from ChromaDex, you can be sure that you are getting patented, extensively researched and rigorously tested NIAGEN straight from the company that pioneered it. Every bottle of TRU NIAGEN has to meet the highest standards for safety, potency, and purity.

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Photos/StockSnap.io/Author

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Want to Age Better? Look to Your Cells – The Good Men Project (blog)

Biologists beat back death in fruit flies. Humans next? – New Atlas

Researchers at the University of California, Los Angeles (UCLA) have figured out a way to extend the life of female fruit flies by 20 percent by manipulating what the school has called a “cellular time machine.” The biologists who carried out the work are hopeful that their findings will have implications for human aging and help fight off age-related diseases like Alzheimer’s and Parkinson’s.

The researchers focused on mitochondria, tiny structures that act a bit like digestive organs inside our cells. These “cellular power plants” take the chemicals and oxygen in our systems provided through food and respiration, and convert them into a molecule known as ATP, which the cell can then use as food. When mitochondria age however, they can become damaged and build up in the body, creating a toxic environment conducive to disease formation.

In the research, UCLA biologists studied the mitochondria in fruit flies and figured out that as the insects reach middle age which, for a fruit fly, is about one month old their mitochondria change shape, making it tough for their cells to clear them out when the organelles are no longer functioning properly.

“We think the fact that the mitochondria become larger and elongated impairs the cell’s ability to clear the damaged mitochondria,” said David Walker, a UCLA professor of integrative biology and physiology, and the study’s senior author. “And our research suggests dysfunctional mitochondria accumulate with age, rather than being discarded.”

So the scientists gave the flies a hand by increasing a protein called Drp1 for one week when they reached 30 days of age. The result was that the damaged mitochondria was broken up into smaller pieces that the flies were able to expel from their cells. This not only led female flies to live about 20 percent longer and male flies to live about 12 percent longer than their typical two-month lifespans, but the researchers also found that the flies had increased energy levels and endurance.

What’s more, the boost in Drp1 also held off a condition in which the flies get leaky intestines about a week before they die. The condition is not only a precursor to death in fruit flies but it has also been implicated in the death of monkeys, worms and mice.

“It’s like we took middle-aged muscle tissue and rejuvenated it to youthful muscle,” said Walker. “We actually delayed age-related health decline. And seven days of intervention was sufficient to prolong their lives and enhance their health.”

The biologists also further experimented with a protein called Mfn, which keeps mitochondria from clumping together and getting too big for cells to deal with. When they turned its production off in the flies, they saw similar benefits in terms of health and life extension.

“You can either break up the mitochondria with Drp1 or prevent them from fusing by inactivating Mfn,” said Anil Rana, a UCLA project scientist and the study’s lead author. “Both have the same effect: making the mitochondria smaller and extending lifespan.”

The team hopes that it may eventually be possible to create a drug that would work in the same way as the proteins to not only extend and improve the lives of humans, but to help stave off age-related diseases. Walker points to the fact that the treatment worked so fast as a major plus, considering that it could lessen the negative effects often associated with the long-term use of pharmaceuticals.

The findings have been reported in the journal Nature Communications.

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Biologists beat back death in fruit flies. Humans next? – New Atlas

Lundin Mining Announces 2017 Mineral Resource and Mineral Reserve Estimates – MarketWatch

TORONTO, ONTARIO, Sep 05, 2017 (Marketwired via COMTEX) — TORONTO, ONTARIO–(Marketwired – Sept. 5, 2017) – Lundin Mining Corporation (LUN)(omx:LUMI)(“Lundin Mining” or the “Company”) today reported its Mineral Resource and Mineral Reserve estimates as at June 30, 2017. On a consolidated and attributable basis, contained metal in the Proven and Probable Mineral Reserve categories totaled 3,232 kt of copper, 3,415 kt of zinc and 130 kt of nickel.

Commenting on the update, Mr. Paul Conibear, President and CEO of Lundin Mining said “We are pleased that our exploration efforts continue to add great value to our assets. Exploration success at Candelaria has resulted in further significant increases in underground Mineral Resources and Mineral Reserves that will allow us to continue to advance mine plan optimization and mine life extension in Chile. Study work and approval of the Zinc Expansion Project at Neves-Corvo and the Eagle East development at Eagle during the last year have contributed to increased Mineral Reserves at both mines. In the light of improved market conditions, we plan to accelerate exploration at all our mine sites in 2018 as well as advance at least two new copper-focused greenfield exploration projects”.

Highlights

Total Candelaria Measured and Indicated MineralResources have increased by approximately 7.5% to 740.9Mt at 0.70%Cu, from 689.0 Mt at 0.64% Cu reported as of June 30, 2016, reflecting thecontinued success of the exploration campaigns.

Total Candelaria Proven and Probable MineralReserves have increased by approximately 3% to 497.5Mt at 0.56% Cu,despite mining depletion. The open pit Proven and Probable MineralReserves, excluding stockpiles, have decreased to 315.9 Mt at 0.53% Cu, from337.6 Mt at 0.54% Cu reported as of June 30, 2016, reflecting 12 months ofdepletion by mining.

Total Candelaria Underground Proven and ProbableMineral Reserves now stand at 89.3 Mt at 0.88% Cu. This is a significantincrease of 38.1 Mt over last year reflecting continued explorationsuccess, particularly in the Candelaria Norte underground mine.

An initial Eagle East Probable Mineral Reservewas reported on April 10, 2017 containing 1.5Mt at 3.7% Ni and 3.0%Cu. The total combined Eagle and Eagle East Proven and Probable MineralReserves now stand at 4.7 Mt at 2.7% Ni and 2.3% Cu.

Copper Proven and Probable Mineral Reserves atNeves-Corvo increased to 29.1 Mt at 2.4% Cu from 26.1 Mt at 2.7% Cu reportedas of June 30, 2016, despite mining depletion.Zinc Proven and ProbableMineral Reserves have increased to 30.4 Mt at 7.7% Zn from 23.4 Mt at 7.2%Zn reported as of June 30, 2016, reflecting approval of the Zinc ExpansionProject.

Total copper Measured and Indicated MineralResources at Neves-Corvo has been reduced by mining depletion and geologicalre-interpretation to stand at 61.7 Mt at 2.4% Cu compared to 70.0 Mt at 2.7%Cu reported as of June, 2016.However, the total zinc Measured andIndicated Mineral Resources remain almost unchanged at 106.5 Mt at 6.1%Zn.

At Zinkgruvan, the zinc Proven and ProbableMineral Reserves have increased to 11.9 Mt at 7.2% Zn and 2.9% Pb andcopper Proven and Probable Mineral Reserves have increased to 5.3 Mt at1.8% Cu.

The tables attached to this release summarize the Mineral Reserve and Mineral Resource estimates for each of the Company’s mines as of June 30, 2017.

About Lundin Mining

Lundin Mining is a diversified Canadian base metals mining company with operations in Chile, the United States of America, Portugal, and Sweden, primarily producing copper, nickel and zinc. In addition, Lundin Mining holds an indirect 24% equity stake in the Freeport Cobalt Oy business, which includes a cobalt refinery located in Kokkola, Finland.

This is information that Lundin Mining Corporation is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact persons on September 5, 2017 at 5:00 p.m. Eastern Time.

Cautionary Statement in Forward-Looking Information

Certain of the statements made and information contained in this news release (including, but not limited to, the attached “Mineral Resources and Mineral Reserves – June 30, 2017” tables and notes thereto) is “forward-looking information” within the meaning of the Canadian securities laws. Forward-looking statements include, but are not limited to, statements with respect to the estimation of Mineral Reserves and Mineral Resources, planned production increases, exploration, mine plan optimization, mine life extension, and project study and development.Forward-looking statements are subject to a variety of risks and uncertainties which could cause actual events or results to differ from those reflected in the forward-looking statements, including, without limitation, risks and uncertainties relating to foreign currency fluctuations; risks inherent in mining including environmental hazards, industrial accidents, unusual or unexpected geological formations, ground control problems and flooding; risks associated with the estimation of Mineral Resources and Reserves and the geology, grade and continuity of mineral deposits; the possibility that future exploration, development or mining results will not be consistent with the Company’s expectations; the potential for and effects of labour disputes or other unanticipated difficulties with or shortages of labour or interruptions in production; actual ore mined varying from estimates of grade, tonnage, dilution and metallurgical and other characteristics; the inherent uncertainty of production and cost estimates and the potential for unexpected costs and expenses, commodity price fluctuations; uncertain political and economic environments; changes in laws or policies, foreign taxation, delays or the inability to obtain and maintain necessary governmental permits; and other risks and uncertainties, including those described under “Risk and Uncertainties” section of the Company’s most recently filed Annual Information Form and the “Managing Risks” section of each of its Management’s Discussion and Analysis. Forward-looking information is in addition based on various assumptions including, without limitation, the expectations and beliefs of management, the assumed long term price of copper, nickel, lead and zinc; that the Company can access financing, appropriate equipment and sufficient labour and that the political environment where the Company operates will continue to support the development and operation of mining projects. Should one or more of these risks and uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described in forward-looking statements. Accordingly, there can be no assurance that forward-looking information will prove to be accurate, and so readers are advised not to place undue reliance on forward-looking statements. The Company does not undertake to update such forward-looking information unless required under applicable laws.

Cautionary Notes to Investors – Mineral Resource and Reserve Estimates

In accordance with applicable Canadian securities regulatory requirements, all Mineral Reserve and Mineral Resource estimates of the Company disclosed or incorporated by reference in this news release have been prepared in accordance with Canadian National Instrument 43-101 – Standards of Disclosure for Mineral Projects adopted by the Canadian Securities Administrators (“NI 43-101”) and are classified in accordance with the Canadian Institute of Mining Metallurgy and Petroleum’s “CIM Definition Standards for Mineral Resources and Mineral Reserves” adopted on May 10, 2014 (the “CIM Standards”).

Mineral Resources which are not Mineral Reserves do not have demonstrated economic viability. Pursuant to the CIM Standards, Mineral Resources have a higher degree of uncertainty than Mineral Reserves as to their existence as well as their economic and legal feasibility. Inferred Mineral Resources, when compared with Measured or Indicated Mineral Resources, have the least certainty as to their existence, and it cannot be assumed that all or any part of an Inferred Mineral Resource will be upgraded to an Indicated or Measured Mineral Resource as a result of continued exploration. Pursuant to NI 43-101, Inferred Mineral Resources may not form the basis of any economic analysis, including any feasibility study. Accordingly, readers are cautioned not to assume that all or any part of a Mineral Resource exists, will ever be converted into a Mineral Reserve, or is or will ever be economically or legally mineable or recovered.

To view the table “Mineral Resources and Mineral Reserves – June 30, 2017”, please click on the following link: http://media3.marketwire.com/docs/Lundin.pdf

Notes on Mineral Resource and Mineral Reserve Table

Mineral Resources and Mineral Reserve estimates are shown on a 100 percent basis for each mine. The Measured and Indicated Mineral Resources are inclusive of those Mineral Resources modified to produce the Mineral Reserves. All estimates are prepared as at June 30, 2017.

Estimates for all operations are prepared by or under the supervision of a Qualified Person as defined in National Instrument 43-101, or have been audited by independent Qualified Persons on behalf of Lundin Mining.

Mineral Reserves have been calculated using metal prices of US$2.75/lb copper, US$1.00/lb zinc, US$1.00/lb lead, US$8.00/lb nickel, US$1,000/oz gold and exchange rates of EUR/US$ 1.25, US$/SEK 7.00 and Chilean Peso/US$ 550.

Candelaria and Ojos

Open pit Mineral Resources are reported within a conceptual pit shell based on metal prices of US$3.16/lb copper and US$1,000/oz gold and are reported at a cut-off grade of 0.2% copper. Underground Mineral Resources are reported at a cut-off grade of 0.6% copper.Mineral Reserves for the open pit and underground for the Candelaria property are reported at cut-off grades of 0.28% and 0.6% copper, respectively. Underground Mineral Reserves for the Ojos del Salado property (Santos and Alcaparrosa mines) are reported at cut-off grades of 0.63% and 0.66% copper, respectively. Mineral Resources and Mineral Reserves for Candelaria and Ojos del Salado were estimated by mine technical staff at Candelaria and Ojos, respectively.Patricio Caldern, Superintendent Resource Estimation, Yerko Peralta, Open Pit Mine Engineer and Cristian Erazo, Underground Mine Engineer, each of whom is a Registered Member, Chilean Mining Commission, employed by the Candelaria mining complex and a Qualified Person as defined under NI 43-101, supervised the preparation of the Mineral Resource, open pit Mineral Reserve and underground Mineral Reserve estimates respectively, and the scientific and technical information on Candelaria contained in this news release.

For further information, refer to the Technical Report entitled Technical Report for the Candelaria Copper Mining Complex, Atacama Province, Region III, Chile dated January 17, 2017, which is available on the Company’s SEDAR profile at http://www.sedar.com.

Neves-Corvo and Semblana

The Mineral Resources are reported above cut-off grades of 1.0% for copper and 3.0% for zinc. The copper and zinc Mineral Reserves have been calculated using variable Net Smelter Return (NSR) values based on area and mining method.The NSR is calculated on a recovered payable basis taking in to account copper, lead, zinc and silver grades, metallurgical recoveries, prices and realization costs. The copper Mineral Reserves are reported above a site average cutoff grade equivalent to 1.3%. For zinc Mineral Reserves an average cutoff grade equivalent to 5.5% is used.Mineral Reserves and Mineral Resources for Neves-Corvo were estimated by the mine geology and mine engineering departments at Neves-Corvo under the guidance of David Nicholls, Technical Services Manager, Nelson Pacheco, Chief Geologist, and Fernando Cartaxo, Chief Mine Planning Engineer, each of whom is employed by the Neves-Corvo mine.Nelson Pacheco EurGeol, prepared the Neves Corvo Mineral Resource estimate and Antonio Salvador, CEng MIMMM, Group Mining Engineer, Lundin Mining, reviewed and approved the Mineral Reserve estimate, and the scientific and technical information for Neves-Corvo contained in this news release. Both are Qualified Persons as defined under NI 43-101.

The Mineral Resources at Semblana are reported above a cut-off grade of 1.0% copper.The Mineral Resource estimate contained in this news release was prepared by Graham Greenway, Pr.Sci.Nat., Group Resource Geologist, Lundin Mining, who is a Qualified Person as defined under NI 43-101.

For further information, refer to the Technical Report entitled NI 43-101 Technical Report for the Neves-Corvo Mine, Portugal dated June 23, 2017, which is available on the Company’s SEDAR profile at http://www.sedar.com.

Zinkgruvan

The zinc Mineral Resources and Mineral Reserves are reported above a site average cut-off grade of 3.7% zinc equivalent. The copper Mineral Resources and Reserves are reported above cut-off grades of 1.0% and 1.5% respectively. The zinc Mineral Reserves have been calculated using variable NSR values based on area and mining method.The NSR is calculated on a recovered payable basis taking in to account copper, lead, zinc and silver grades, metallurgical recoveries, prices and realization costs.The Zinkgruvan Mineral Resource and Mineral Reserve estimates are prepared by the mine’s geology and mine engineering department under the guidance of Anja Hagerud, Resource Manager, and Jan Klre, Mine Manager, both employed by Zinkgruvan mine.Graham Greenway, Pr.Sci.Nat., Group Resource Geologist, Lundin Mining and David Allison, CEng MIMMM, Group Mining Engineer, Lundin Mining, each of whom is a Qualified Person as defined under NI 43-101, reviewed and approved the Mineral Reserves and Mineral Resource estimates and the scientific and technical information for Zinkgruvan contained in this news release.

For further information, refer to the Technical Report entitled NI 43-101 Technical Report for the Zinkgruvan Mine, Central Sweden dated January 18, 2013, which is available on the Company’s SEDAR profile at http://www.sedar.com.

Eagle and Eagle East

The Eagle Mineral Resources and Mineral Reserves are reported above a fixed NSR cut-off of US$116/t. The Eagle East Mineral Resources and Reserves are reported above a fixed NSR cut-offs of US$142/t and US$160/t respectively. The NSR is calculated on a recovered payable basis taking in to account nickel, copper, cobalt, gold and PGM grades, metallurgical recoveries, prices and realization costs. The Eagle Mineral Resource and Mineral Reserve estimates are prepared by the mine’s geology and mine engineering department under the guidance of Robert Mahin, CPG, Chief Geologist and Josh Lam, Senior Mine Engineer, both of whom are employees of the Eagle mine. The Eagle East Mineral Resource estimate was prepared by Graham Greenway, Pr.Sci.Nat., Group Resource Geologist, Lundin Mining.Robert Mahin prepared the Eagle Mineral Resource estimate and reviewed and approved the Eagle East Mineral Resource estimate and David Allison, CEng MIMMM, Group Mining Engineer, Lundin Mining, reviewed and approved the Eagle and Eagle East Mineral Reserve estimates and the scientific and technical information on Eagle and Eagle East contained in this news release. Both are Qualified Person as defined under NI 43-101.

For further information, refer to the Technical Report entitled Technical Report on the Eagle Mine, Michigan, U.S.A. dated April 26, 2017, which is available on the Company’s SEDAR profile at http://www.sedar.com.

Mark Turner Director, Business Valuations and Investor Relations +1-416-342-5565 Sonia Tercas Senior Associate, Investor Relations +1-416-342-5583 Robert Eriksson Investor Relations Sweden +46 8 545 015 50

2017 Nasdaq, Inc. All rights reserved.

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Lundin Mining Announces 2017 Mineral Resource and Mineral Reserve Estimates – MarketWatch

QuantumClean and ChemTrace to Exhibit at SEMICON Taiwan 2017 – Markets Insider

Validated Ultra-High Purity. Maximum Productivity.

QUAKERTOWN, Pennsylvania, Sept. 6, 2017 /PRNewswire/ –Quantum Global Technologies’ companies,QuantumCleanandChemTrace,will exhibit at SEMICON Taiwan 2017 at the Taipei Nangang Exhibition Center from September 13 – 15 (booth 1718).

Logo -https://mma.prnewswire.com/media/383596/Quantum_Global_Technologies_LLC_Logo.jpg

This year, Quantum Global Technologies unveiled the world’s most advanced semiconductor chamber parts cleaning, coating and analytical facility in Tainan.

“This plant is a ‘Smart, Lean, Clean and Green’ Center of Excellence, a first of its kind in its industry. The opening of this advanced facility is yet another milestone in our evolution. A demonstration of our continuous innovation, growth and value generation for our customers,” states Scott Nicholas President and CEO, Quantum Global Technologies, LLC.

“Our Tainan cleaning, coating and analytical testingCenter of Excellencehelps our customersREDUCE cost-of-ownership.Analytically validated ultraclean parts result inFASTER chamber recoveryandLONGER Mean Time Between Cleans. Optimized cleaning methods and proprietary recoating technologiesEXTEND part life. Fast part turnaround timesREDUCE inventory costs. We are the only firm to offer ultra-high purity chamber part cleaning validated by aCertificate of Analysisfrom an accredited laboratory,” explains Nicholas.

The Tainan site is Taiwan’s only cleaning and coating service provider with an embedded microcontamination laboratory ChemTrace.

ChemTraceis an industry-leading semiconductor laboratory that provides critical insight into microcontamination issues. “The recent laboratory opening in Tainan allows regional semiconductor industry customers direct access to our advanced laboratories for rapid turnaround and expert analysis,” explains Surjany Russell, ChemTrace’s Director of Sales.

We welcome your visit to theQuantumCleanandChemTracebooth to learn more on how our service offerings can bring improvement to your operation by solving critical process chamber manufacturing challenges.

About Quantum Global Technologies, LLC

ChemTraceandQuantumCleanare divisions of Quantum Global Technologies, LLC headquartered in suburban Philadelphia, Pennsylvania USA.

QuantumCleanis the global leader in sub-10nm outsourced process tool chamber parts cleaning and coating services, tool part life extension and process tool part optimization solutions to the semiconductor wafer fabrication, OEM and OPM industries.

Founded in 2000,QuantumCleanoperates innovativeAdvanced Technology Cleaning Centersbuilt on the premise of providing customersprocess improvement through consistently cleaner partsthat exceed industry standards. These solutions dramatically reduce our customers’ total cost-of-ownership. With 1,500 employees in 18 facilitieslocated in 8 countries,QuantumCleanprovides unsurpassed cleaning capability and convenience worldwide.quantumclean.com

For over 20 years,ChemTracehas provided independent and analytical verification of process tool chamber part cleaning effectiveness. Recognized as the leading reference analytical testing laboratory for the semiconductor, solar and related industries,ChemTracehas the solutions for FAB, OEM and OPM’s critical cleaning issues and requirements. With more than 100 employees in 5 labs located in 3 countries,ChemTraceoffers unsurpassed microcontamination analysis of tool parts, wafers and depositions, chemicals, cleanroom materials, DI water and airborne molecular contamination.chemtrace.com

Media Contacts

QuantumClean:Meg Cox, +1-215-892-9300, rel=”nofollow”>info@quantumclean.com

ChemTrace:Robin Puri, +1-503-251-0979, rel=”nofollow”>info@chemtrace.com

QuantumClean, ChemTrace, Advanced Technology Cleaning Centers, ATCC, Process Improvement through Consistently Cleaner Parts, Single Part Chemical Clean and SPCC are all registered trademarks of Quantum Global Technologies, LLC.

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QuantumClean and ChemTrace to Exhibit at SEMICON Taiwan 2017 – Markets Insider

STEHLIK: Thank you for smoking – Yale Daily News (blog)

Iwish more people at Yale took smoke breaks.

No, I am not a misanthrope, wishing premature death upon my classmates, nor do I long for the aesthetic of DeNiro gangster movies. I realize smoking is horrible 6 million deaths each year, with 80 percent of the disease burden falling on low and middle income countries. Who knows if my grandfather would have had a stroke last year if he hadnt smoked since 1949. And dont even get me started on the tobacco industry outright lying to people around the world and suing countries trying to pass smoking regulation. Honestly, just ask my smoker friends there is no one who professes life extension through smoking cessation as aggressively as I do.

Yet, as the stress and isolation of Yale hits me hard, I text friend after friend inviting them to meet up. And my heart sinks deeper as friend after friend politely lets me know how extremely busy they are. So I light up alone on the back porch of my Howe Street house god, I miss smokers.

None of my Yale friends smoke. Yalies are too rational for this short-term indulgence. The truth has nothing to do with rationality and everything to do with incentives. In the U.S., smoking is a stigmatized lower class habit and so putting down the cigarette is just another Canada Goose patch Yale students proudly wear. The only real smokers left at Yale are international students and dining hall workers.

Going to high school in Bosnia and Herzegovina a country that ranks 10th worldwide in cigarette consumption per capita I made some of my best friends while smoking. As much as I know that my friends will regret their tobacco habit 40 years down the road, I think there are also considerable positive externalities to this addiction.

For one, Ive never had a hard time asking my friends in Bosnia for five minutes of their time they literally needed to smoke every half-hour, so they might as well do it with me.

Smoking makes for a perfect way to meet new people. From light to ash, a cigarette takes six minutes. There is no shame about being silent with another person because smoking itself gives you a good enough occupation. It is the perfect way to get out of a party mingle hell and have an actual conversation with someone. The closest thing to a smoke break at Yale are 30-minute dining hall meals, which you must plan literally weeks in advance.

There is something liberatingly nihilistic about knowing how harmful smoking is and lighting up anyway. The cigarette in my Slovak friends hand is a raised middle finger to the idea of progress and universal betterness we toil for, 14 hours a day.

Since, apart from my two-house mates who ritually pretend to take drags from a cigarette about every two months, I know no Yale smokers. It is hard for me to say whether smoking would make us kinder to each other. Even if it did, it probably would not compensate for all the strokes, cancer and erectile dysfunction that would come with smoking. It would also not justify the inherent deception involved in nicotine addiction intensely pleasurable at first, but bland, necessary and somewhat deadly over time.

Setting up incentives so that fewer people smoke is a great achievement for the United States. Tobacco-free Yale is an excellent and important initiative and cost-free Nicotine Replacement Therapy under Yale Health coverage is surely a blessing for anyone trying to stop. But still, what would it be like here if we tried to chill out in less risky ways? I heard walks are pretty relaxing.

While Yales environment constructively discourages smoking, it unwillingly encourages overwork, perfectionism, low self-esteem and putting work ahead of friends. If only banning social climbing and status obsession was as easy as banning tobacco.

Mojmir Stehlikis a junior in Trumbull College. Contact him atmojmir.stehlik@yale.edu.

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STEHLIK: Thank you for smoking – Yale Daily News (blog)

Houghton International gains EASA accreditation – BQ Live

Founded in 1984, Houghton International has expanded over the last 30 years into a multi-million pound, multinational business. Specialising in innovation in the repair, maintenance and life extension of rotating electrical machines, the company has grown from originally serving one customer to now working with over 200 customers globally in a broad range of sectors including power generation, renewables, industrial, oil & gas, marine and rail.

Having opened a large machine repair shop and invested over 300,000 in plant and machinery over the past year to improve performance and keep up with demand,EASA accreditation means that the companyhas successfully demonstrated that it complies with EASA AR100 and follows the prescribed good practices to consistently deliver quality electromechanical repairs that maintain or improve AC electric motor efficiency and reliability.

Michael Mitten, CEO of Houghton International, commented: With over 30 years experience in the repair, maintenance and life extension of electrical rotating machines, becoming an EASA accredited service centre reaffirms our commitment to delivering high quality repairs to our UK and global customer base.

EASA is the worlds leading authority in electro mechanical repair and maintenance, and represents the highest standard and best practice in this industry. Our customers can be assured that any work carried out in our shop meets with or exceeds these standards and be confident in our service.

Linda J. Raynes, CAE, EASA president and CEO said: “This achievement by Houghton International affirms the company’s commitment to excellence. EASA’s accreditation program offers external validation that the company adheres to good practices by submitting to an independent, third-party audit.”

EASA is the electro-mechanical authority; an international trade organisation consisting of more than 1,800 electromechanical sales and service firms in 59 countries. EASA member companies provide repair, service, and sales for the operation and maintenance of electric motors, generators, drives, controls, pumps and other electromechanical equipment.

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Houghton International gains EASA accreditation – BQ Live

Open Longevity Project: a Scientific Approach to Conquer Aging – Blockchain News

A new project in the field of biotechnology, telemedicine, clinical research and medical services is completing preparations for pre-ICO. Open Longevity is organizing research of anti-aging therapies in humans by providing online advisory services. Their ultimate goal is to find and introduce effective methods of radical life extension into clinical practice. Therefore, the tokens are called YEAR.

The project claims they will combine the capabilities of modern IT-systems, the expertise of leading scientific analysts and the energy of the patients themselves. Another driving force they emphasize is openness and rejection of commercial benefits in those matters where this can affect the objectivity of scientific research.

One of the common concerns, when antiaging drugs are being mentioned, is that, once proven effective, anti-aging medicine will become available only to the elite. The fact that the trials results will belong to the patients community, might be a possible solution to this potential problem.

Mikhail Batin, the CEO of Open Longevity, states he is sure that effective ways to delay the onset of aging will be foundit is only a matter of time. He and his colleagues just want to accelerate the research.

The project consists of two parts: clinical trials and online service. Part of the funds raised through ICO will be spent on the first three studies: Longevity Diet-1 (a variant of a fasting mimicking diet); Alzheimers disease therapy (vitamin B12) and atherosclerosis therapy (sartans + statins). One can even find documents for the first trial in progress, though just in Russian yet. As the trial is planned to be submitted to NIHs https://clinicaltrials.gov, the documents will be translated into English at some point.

All the subsequent studies will later be also funded: life extension projects are expected to be submitted for voting on a general basis, voting will be conducted among all the YEAR token holders.

All clinical trials will be carried out in strict accordance with existing norms. Thus CROs (contract research organizations), laboratories, and clinical institutions that traditionally carry out similar research, will be involved. But OL team is already talking about making all paperwork more automated.

Another part of the funds will be spent on creating an online platform. By uploading biomedical data, users will be able to monitor their health and aging status in dynamics; receive recommendations from specialists and expert system based on AI; and also become volunteers in trials.

The service will be accessible to everyone. But payment with YEAR tokens is promised to be more favorable than paying with fiat currencies due to 50% discount. This, among other points mentioned in projects WP, has to maintain a constant token flow within the system and ensure the stability of its exchange rate.

The first three days of pre-ICO is going to be in the format of Private Placement. The registration has started already, but the date of preICO launch itself will be announced in advance in projects channels in Telegram.

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Open Longevity Project: a Scientific Approach to Conquer Aging – Blockchain News

Texas relief funds benefit farmers and ranchers – Kotatv

RAPID CITY, S.D. (KOTA TV) – Hurricane Harvey is still wreaking havoc in Texas, and South Dakota farmers and ranchers are no stranger to the affects of Mother Nature.

“What the country did for South Dakota ranchers and particularly those ranchers in our neck of the woods was awesome, said Kadee Handee, marketing manager of the Black Hills Stock Show and Central States Fair. We want to make sure that your donation will go to an organization that will truly use it.”

Hurricane Harvey has displaced many families from their home, but also cattle from their pastures.

According to the U.S. Department of Agriculture, about 1.2 million beef cows are registered in the 54 counties that have been declared as disaster areas.

Hundreds of pets have been rescued from the rising waters as well. If you are interested in donating to that cause, seek out local shelters in Houston and San Antonio.

But there are other ways to donate as well. Tangible donations like hay, resources and even animals can be made to the Agri-Life Extension.

“It is an arm of the Extension Agency in Texas that will be able to facilitate those demands and facilitate those resources to those ranchers that are affected, said Handee

The Texas FFA Association and the Texas A&M Veterinary Emergency Team are some more reputable organizations that are accepting donations for relief funds.

Donations can also be mailed to: Cattleraisers Relief1600 Gindy St. Ft. Worth, TX 76107

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Texas relief funds benefit farmers and ranchers – Kotatv

Askelos, ITF launch JIP – OE Digital

The Industry Technology Facilitator (ITF) and Akselos have announced they will work together to investigate the potential to revolutionise asset management in the oil and gas industry.

The initiative will bring a joint industry project (JIP) to ITF member companies and beyond, that will prove the transformative impact of the use of a Digital Guardian for ageing offshore assets.

Akselos uses MIT-licenced technology to create the worlds most advanced engineering simulation technology – or digital twins. The tech is based on algorithms that are 1000 times faster than those typically used in conventional design technology, enabling detailed and accurate structural simulations of large-scale operational assets.

The companys vision is to combine the simulation software with sensors and big data analytics to create an exact virtual replica of an asset in its current environment, which the company describes as a Digital Guardian. This will allow operators real-time access to the condition of their asset from anywhere at any time and allow a move towards predictive and preventative maintenance. It will also better inform the decision making process with Asset Life Extension, using data to reassure operators that assets are safe to continue operating beyond their design life.

Dr Patrick OBrien, CEO of ITF, said: The creation of a Digital Guardian or twin of an offshore asset is a huge step forward for the oil and gas industry and will reap long-term benefits to enhance operational and cost-efficiencies as well as significantly reduce risk. It will also advance information management and collaboration, where the experts and operators can work together, preventing costly mistakes and rework.

The partnership with ITF will see the global technology facilitator leverage its network and expertise from previous projects and activities to bring together forward-thinking operators to the JIP. ITF will play a project stewardship role throughout the two-year project to maximise the benefits to the companies involved and facilitate advancements in the industry as a whole.

Thomas Leurent, Akselos CEO said: Our vision for a Digital Guardian to protect assets and infrastructure would have been science fiction before the technology breakthrough in 2011, which we have patented and validated across industries. Were conducting this particular JIP to obtain data that will help illustrate the impact to the oil and gas industry. Its a huge opportunity to create efficiencies and slash operating expenditure.

The US$2 million JIP has been partly funded by Eurostars and the Swiss Commission for Tech Innovation. Akselos has partnered with leading design and engineering consultancy, LICengineering to deliver the project. In the first year of the JIP, members will receive a condition-based model of their selected assets, enabling them to analyse structural integrity with more accuracy and detail than ever before. In the second year, Akselos will combine this with sensor data to allow operators to monitor the health of their asset in real-time and predict its future condition.

Leurent added: While our technology is relevant at all stages in asset management, it has huge potential in asset life extension (ALE). With over half of the platforms in the North Sea operating beyond their design life, a Digital Guardian will allow operators to understand the remaining structural capacity of the asset and make informed decisions about ALE.

One supermajor operating in the North Sea has already signed up to the two year JIP. ITF is now actively seeking other operators from both its international membership and project participants to take advantage of this leveraged funding.

Dr OBrien continued: The JIP is an exciting opportunity for pioneering players in the sector to learn and share solutions. Ultimately, it is a chance to be part of an initiative which will revolutionise the industry and bring it on par with the medical, automotive and aerospace industries.

Eurostars is a billion dollar fund aimed at supporting international projects that develop rapidly marketable innovative products and services to improve the daily lives of people around the world. It is funded by the European Unions Horizon2020 fund and individual participating states national budgets.

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Askelos, ITF launch JIP – OE Digital

Can Dietary Changes Extend Your Life? – AlterNet

Turmeric has been associated with protection from heart disease, stroke and dementia.Photo Credit: tarapong srichaiyos/Shutterstock

The following excerpt is from the new bookCracking the Aging Code:The New Science Of Growing Old And What ItMeans For StayingYoung, by Josh Mitteldorf, Ph.D., and Dorion Sagan (Flatiron Books, 2017).

The realization that aging is self-imposed, something your body is doing to itself on purpose, yields a new perspective on health maintenance and longevity. There are things we can do to add years to our lives and things we can do to be healthier in the present, and fortunately for us, these are mostly the same things. A program for life extension is likely to make you feel better in the present and even help you get sick less frequently.

Much of what I have to recommend for self-care is already standard medical advice. Exercise, weight loss, and a daily aspirin or ibuprofen are among the best things you can do for yourself, and Im sure you didnt hear that first from me. But there is also something new in our program to cheat the Black Queen. The most difficult conceptual leap I ask of you is to question all reverence for the natural. I grew up with the counterculture and celebrated the first Earth Day when I was a college student. Culturally and socially, I feel at home with the crunchy granola crowd, so imagine a lilt of sadness in my voice as I tell you that natural has little to offer for life extension.

Substances that have been found to lower mortality rates in humans are anti-inflammatories (such as aspirin and ibuprofen), vitamin D, and the diabetes drug metformin (Glucophage). Fish oil and turmeric are natural anti-inflammatories that have been associated with protection from heart disease, stroke, and dementia. Substances that increase life span when fed to rodents include metformin, melatonin, and deprenyl (Selegiline). Rapamycin is the most recent and most powerful of the drugs that extend life span in mice, but it is likely to leave us vulnerable to a lot of infectious diseases, and I dont recommend it.

Vitamin D is in a class by itself. High blood levels of vitamin D are associated with lower risk of cancer and infectious diseases, and no one really understands why.

Telomerase activationthe turning on of the genes to resume production of this biologically rationed enzyme needed for sustained cellular reproductionis a promising idea for the future, but what is available now is not very effective. Still, it might be worth adding to your regimen.

A low-carb diet coupled with periods of intermittent fasting provides the easiest way to fool the body into thinking it is getting less nourishment than you are actually eating, with likely benefits for health and longevity.

People who are happy, passionate about their work, and engaged daily with friends and family live a lot longer than people who are depressed and isolated. Share your gifts with others and you will have a long and satisfying life. This is no small thing.

Deconstructing the Natural

Most of us cant remember a time before the meta-marketing phenomenon of natural. But fifty years ago, technology was king, and we had no compunctions about improving on nature. In the 1950s, tonsils were ripped from the throats of small children because they had a tendency to turn red during laryngeal infections, so doctors thought nature had made a mistake. In the 1950s, Dr. Spock had to break with standard medical advice to recommend breast- feeding over infant formula. And dont forget that Wonder Bread helped build strong bodies twelve ways. For half a century, we have been told about natural foods, cosmetics, soaps, herbal remedies, and even items of clothing. Natural = healthy. The medical establishmentmuch to its credithas learned to respect the body and work with it to promote natural healing, rather than rush to fix what aint broke. Today, natural treatments for every disease are often presumed to be preferable whenever such are available.

So far so good, but it takes some reflection for us to take the next step. We must acclimate to a different reality about aging: natural diets, herbs, and remedies are unlikely to slow the aging process.

This book has argued that aging is not a bug in evolutions program but a design feature that is naturally selected in its own right. Aging is natural in the deepest sense, that it is a product of evolution, built into our genes. At root, the appeal of the natural comes from faith in evolutionwhat is natural is part of the environment in which humans and our ancestors evolved; hence we are presumed to be well adapted to it. If natural foods are better for us, it is because they are the foods that evolution has equipped our bodies to work with. (Follow this logic a step further and you reach the paleo diets that try to mirror ancestral food choices.) Natural selection has not prepared us for the pace of life in the jet age or for breathing smog or drinking Coca-Cola; hence many of the complaints of modern life may be attributed to a mismatch between the life we are living and the life for which evolution has prepared us. And indeed, it is likely true that many of our ailments are products of modernity: lung cancer from cigarettes and urban smog, metabolic syndrome (increased fat, blood pressure, blood sugar, and other factors leading to type 2 diabetes) from junk food, nervous disorders from overstimulation, and depression from living in a fragmented and disconnected society.

Theoretical biologist Josh Mitteldorf has a Ph.D. from the University of Pennsylvania. He runs the website AgingAdvice.org, and writes a weekly column for ScienceBlog.com. Mitteldorf has had visiting research and teaching positions at various universities including MIT, Harvard and Berkeley.

Dorion Sagan is a writer, ecological philosopher and author or coauthor of over twenty-four books, which have been translated into over a dozen languages. His work has appeared in Natural History, Smithsonian, Wired and The New York Times.

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Can Dietary Changes Extend Your Life? – AlterNet

USAF completes flight tests of B61-12 gravity bombs from F-15E – Airforce Technology

The US Air Force (USAF) has tested non-nuclear functions of B61-12 gravity bombs at the Tonopah test range in Nevada, US.

The qualification flight tests were conducted in collaboration with the Department of Energys National Nuclear Security Administration (DOE/NNSA).

These tests form a part of a series scheduled to take place over the next three years to qualify the weapon for service, NNSA stated.

As part of the latest tests, the B61-12 gravity bombs were dropped from an F-15E Strike Eagle fighter aircraft based at Nellis Air Force Base.

The testing also involved evaluating the aircrafts capability to deliver the nuclear weapon.

The flight test included hardware designed by Sandia and Los Alamos National Laboratories, manufactured by the Nuclear Security Enterprise plants, and tail-kit assembly section designed by the Boeing Company under contract with the Air Force Nuclear Weapons Center.

“The B61-12 life extension programme is progressing on schedule to meet national security requirements.”

The B61-12 was first tested in March, according to the statement.

NNSA Defense Programs acting deputy administrator Phil Calbos said: The B61-12 life extension programme is progressing on schedule to meet national security requirements.

These realistic flight qualification tests validate the design of the B61-12 when it comes to system performance.

The programme is anticipated to extend the bombs service life by at least 20 years.

It includes revamping, reusing, or replacing all of the bombs nuclear and non-nuclear components.

The B61-12 is intended to replace four B61 bomb variants in the nations nuclear arsenal and the first production unit is expected to be completed by March 2020.

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USAF completes flight tests of B61-12 gravity bombs from F-15E – Airforce Technology

Life Extension Archives – NutraPlanet

Sale!Life Extension 5-Lox Inhibitor with ApresFlex VCaps 100 mg Vitamins & Minerals.

Description For Longer Life Next Generation Boswellia Extract Dietary Supplement Normal aging results in higher-than-desired levels of 5-LOX. The typical American diet adds to the danger. Foods rich in omega-6 fatty acids like red meat poultry eggs and dairy products along with high-glycemic carbohydrates trigger overproduction of arachidonic acid. In response to high levels of []

Description For Longer Life Natural Metabolite of DHEA Dietary Supplement 7-Keto DHEA is a natural metabolite of DHEA that has been shown to safely increase thermogenesis improve fat loss and help maintain healthy body weight when combined with a diet and exercise program. A clinical study indicated that 7-Keto DHEA increases the resting metabolic rate []

Description Foundation for Longer Life With AdipoStat and Integra-Lean African Mango Irvingia Weight Management Support Dietary Supplement Certified Authentic Irvingia This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary. Advanced Anti-Adipocyte Formula with AdipoStat and Integra-Lean African Mango Irvingia AdipoStat targets the mechanisms by which fat-storing []

Description For Longer Life Advanced Oral Hygiene Advanced Oral Hygiene is an oral probiotic that provides the beneficial bacteria that can help block harmful bacteria that first develop in the mouth. This sophisticated oral probiotic therapy allows the healthy and naturally occurring organisms found in the body to out-compete the harmful bacteria. Advanced Oral Hygiene []

Description Clinical Strength Ingredients Convenient Dose Dietary Supplements As you grow older age-related stiffness and discomfort in the joints becomes a fact of life. Activities once routine become a challenge as limited mobility hampers your every move. You now have a more potent option to provide broad-spectrum support for aging joints. ArthroMax Advanced with UC-II []

Description For Longer Life Helps Maintain Healthy Liver Function Dietary Supplement Anti-Alcohol Antioxidants with HepatoProtection Complex Consuming alcoholic beverages results in the generation of free radicals. People who drink a lot of alcohol often suffer because of massive free radical-induced cellular damage. Alcohol-induced free radical assault can wreak short-term havoc throughout the body and these []

Description Foundation for Longer Life Apple-A-Day Antioxidant Dietary Supplement The benefits of plant polyphenols are well known to health enthusiasts. These natural plant constituents block oxidative damage that leads to inflammation and accelerated biological aging of tissues. Recent studies by three separate laboratories have concluded that polyphenols extracted from apples extend life span in laboratory []

Description For Longer Life “High-ORAC Complex” Dietary Supplement One capsule provides the antioxidant equivalent of more than 2 1/2 servings of fruits and vegetables based upon yearly ORAC analysis done by the USDA. Oxygen Radical Absorbance Capacity. Suggested Use Take one (1) capsule daily with or without food or as recommended by a healthcare practitioner. []

Description Promotes Intestinal Health Dietary Supplement Probiotics literally means for life. Traditional diets (like the Mediterranean Diet) with foods that contain probiotics have been shown to promote health and longevity. Probiotics are thought to facilitate healthy GI and perform many other important functions. For example researchers have discovered that probiotics help decrease nuclear factor kappa []

Description For Longer Life Natural Mood and Sleep Support Dietary Supplement Bioactive Milk Peptides (Lactium) are a cutting-edge nutrient complex consisting of patented bioactive peptides found naturally in milk. Used widely in Europe to promote sustained and restful sleep patterns published studies reveal that these bioactive milk peptides also promote relaxation help with stress and []

Description Foundation for Longer Life Modulates Key Regulators of Inflammation Dietary Supplement Black Cumin Seed Oil As we age a balanced immune and inflammatory response becomes critical to guarding our health. Research has shown Black Cumin Seed Oil to be particularly effective. Scientists have determined that black cumin seeds contain a broad spectrum of active []

Description For Longer Life Natures Antioxidant Dietary Supplement Blueberry Extract Capsules The two most active constituents found in blueberries are anthocyanins and pterostilbene. Blueberry anthocyanins are considered one of natures most potent antioxidants. Pterostilbene is the other blueberry constituent that helps maintain healthy lipid and glucose levels that are already within healthy ranges. Through its []

Description For Longer Life (Free Form) Hepatoprotection Dietary Supplement Suggested Use Read the entire label and follow the directions carefully prior to use. To be used by adults 18 years and older. Take four (4) capsules daily with or without food or as recommended by a healthcare practitioner. Other Ingredients Vegetable cellulose (capsule) rice flour. []

Description For Longer Life Sterile Lubricant Eye Drops For use as a lubricant to prevent further irritation or to relieve dryness of the eye. Suggested Use Please read enclosed product insert for important safety information and instructions on opening containers. Instill 1 or 2 drops in the affected eye(s) as needed. Other Ingredients Other Ingredients: []

Description For Longer Life Enteric Coated for Optimal Absorption Dietary Supplement Specially-Coated Bromelain is enteric coated to protect the bromelain from becoming active in the stomach and act as a digestive enzyme for food. Specially-Coated Bromelain Bromelain, a mixture of proteases extracted from the stem of the pineapple, has been used by Europeans for many []

Description Foundation for Longer Life Cellular Support For Heart Muscle Dietary Supplement Cardio Peak with Standardized Hawthorn and Arjuna Cardiotonics have traditionally been used to improve heart function and vitality. Formulated for optimum heart muscle health Cardio Peak with Standardized Hawthorn and Arjuna provides dual cardiotonic support. Extensive research demonstrates that the botanical extracts Hawthorn []

Description Foundation for Longer Life Silymarin-Silibinins-Isosilybin A & B Supports a Healthy Liver and Prostate Dietary Supplement Certified European Milk Thistle (Silymarin-Silibinins-Isosilybin A & B) The liver is a large glandular organ, whose functions include decomposition of red blood cells, plasma protein synthesis, hormone production, secretion of bile, and conversion of sugars into glycogen, which []

Description For Longer Life Supports Healthy DNA Dietary Supplement Suggested Use Read the entire label and follow the directions carefully prior to use. Take one (1) capsule three times daily with food or as recommended by a healthcare practitioner. Other Ingredients Microcrystalline cellulose vegetable cellulose (capsule) silica vegetable stearate. Warnings Store tightly closed in a []

Description Foundation For Longer Life Helps Maintain Healthy Glucose for those already within Normal Range Dietary Supplement Suggested Use Read the entire label and follow the directions carefully prior to use. Take one (1) capsule 20-30 minutes before each meal not exceeding three (3) capsules daily or as recommended by a healthcare practitioner. Best results []

Description Sealed for Your Protection For Longer Life Supports Weight Management and Metabolic Wellness† Certified Authentic Irvingia Dietary Supplement Chrominex †This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary. Suggested Use Read the entire label and follow the directions carefully prior to use. Take one (1) []

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Life Extension Archives – NutraPlanet

Debunking Hollywood’s Portrayals of Human Hibernation – The Atlantic

Nothing says interstellar travel like a hibernation pod. The heroes of the 2016 holiday blockbuster Passengers, played by Jennifer Lawrence and Chris Pratt, embark on a century-long journey to a planet outside our solar system. Hibernation pods extend their lifespans for the long trip, but they wake from torpor 90 years earlier than scheduled. Then they set about trying to fix the ship and trying to put themselves back to sleep.

First of all, lets talk about this waking from hibernation business. Hibernation may involve lying down with ones eyes closed, but theres no sleeping going on; in fact, a long stretch of it leaves the body sleep-deprived. If this movie were true to life, the first thing that would happen when Jennifer Lawrence opened her long-lashed eyes in the hibernation pod would not be her listening to the ship computers crew update. It would be her closing those long lashes again and descending straight into sleep.

Thats because sleep is one of the bodily functions that cant be done properly in hibernation. During the periodic arousal states that punctuate hibernation, animals warm their bodies and go straight into a long, deep sleep. Oxford neuroscientist Vlad Vyazovskiy did his masters work at the Institute for Problems of Cryobiology and Cryomedicine at Kharkov National University in Ukraine, where he studied ground squirrels in torpor.

Originally hibernation was considered a continuation of sleep, but physiologically it is very different because your metabolism is totally suspended, although it is still regulated, says Vyazovskiy. Torpor, this extreme metabolic challenge, seems to do something to the brain or body which necessitates sleep, which in turn provides some type of restoration.

Suspended animation in deep-space flight has been a movie trope since the dawn of science fiction, and for just as long NASA has been working to make it real. John Bradford of SpaceWorks Enterprises has been contracted by NASA to develop just such a technology. Inspired by the unique physiologies of animal hibernators, he is working on overriding the bodys steady 37-degree-Celsius core temperature in a technique called targeted temperature management. Metabolism slows by about 7 percent for every degree of cooling. Though uncontrolled hypothermia can be fatal, a constant 32-degree body temperature still allows for normal nerve functions that are critical for breathing and heartbeats.

Humans cant hibernate, but we can mimic how animals hibernate, he says. Earlier in our evolutionary history we did hibernate, but now its turned off.

Did I mention hes an engineer? Am I the only one who gets worried when engineers are hired to do doctorish things? For one thing, in true hibernators, platelets and white blood cells are sequestered in lymph nodes away from the blood vessels during dormancy. This prevents the blood clots that can form with inactivity and avoids the inflammation that causes kidney damage upon rewarming. There will be a lot of research necessary before humans can safely hit the pause button on their metabolisms. Luckily, Bradford hasnt been permitted any real live human subjects yet.

Then again, doctors have been pursuing this capability for years in the field of emergency medicine. When a severely injured patient arrives at a hospital, minutes count. A rapid cooling of the body saves tissues that are cut off from blood supplya slower metabolism consumes less oxygenso cooling patients for surgery is now a routine procedure. A low dose of narcotics prevents the patient from shivering to warm themselves up. In China, experiments with therapeutic hypothermia put patients into a deep chill for up to two weeks before successfully reviving them.

It really would be great if we could make it happen. The advantages of crew hibernation could mean the difference between a successful Mars colonization and an Earth-bound humanity. Mars is only six months journey from Earth, so life extension is not the primary issue at play, but hibernation pods would cut down the required habitat size and food needs. They could even provide solutions to some of spaceflights most long-standing health issues. Spinal fluid rising into the skull in low gravity causes pressure that diminishes most astronauts eyesight in flight, but the hibernation state should help to clear up that issue.

When humans live without the strain of gravity, muscle atrophy and bone loss also become a problem. Those on the International Space Station have to put in two full hours of exercise per day just to maintain their skeletons. But with hibernation, muscles and bone can be maintained using neuromuscular stimulation, which is unpleasant while conscious but not an issue for a deep-sleeping crew member.

We can exercise you all day long! says Bradford.

Cancer risk from the accumulated exposure to cosmic rays is NASAs primary health concern for astronauts on long-haul space flights, and there is some debate as to whether a slowed metabolism is more vulnerableunable to fend off damage to DNA by repairing itor more immune, because errors in that repair process often trigger the tumors.

In either case, hibernation may be the answer, because it restricts the astronauts range of motion. Magnetic shielding could protect a spacecrafts inhabitants from ionizing radiation, but the shield for a whole habitat would be far too heavy to be feasible. If shields could be produced for a small cot, however, and the astronauts prone body could be protected for the voyage within it, the shield option could be back on the table.

In the future, human hibernation could take even more radical paths. A research group supported by the U.S. Army is experimenting with a technique that cools patients rapidly by replacing their blood with ice-cold saline solution. The total metabolic suspension leaves a body with no heartbeat, no breathing and no discernible brain activity, but when dogs have undergone the treatment, they have been successfully resuscitated after three hours in the frozen state.

Perhaps those dogs will want to be the first interstellar passengers, to take them far away from a planet where their lot in life is to have their blood replaced by ice.

This post appears courtesy of The Last Word On Nothing.

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Debunking Hollywood’s Portrayals of Human Hibernation – The Atlantic

Master Gardeners have scheduled presentations – Athens Daily Review

There will be a Master Gardener presentation by Keith Hanson on Growing Azaleas Thursday, Aug. 31, from 6 p.m. to 7 p.m. at the First United Methodist Church, 507 N. Broad St., Chandler.

Former Agri-Life Extension Agent Keith Hanson will speak on growing azaleas. Hanson was an Extension agent for 29 years. He received his Bachelors and Masters degrees in Horticulture at Texas A & M University and continued his study in Plant Physiology at the University of California at Davis. This presentation is sponsored by the Henderson County Master Gardeners Association and is free to the public. For more information, call 903-675-6130, email hendersonCMGA@gmail.com or visit http://www.henderson-co-tx-mg.org.

Master Gardener Judy Haldeman will present Wild about Wildflowers Tuesday, Sept. 19, at 5:30 p.m. at the Clint W. Murchison Memorial Library 121 S. Prairieville, Athens.

Come learn the basics of gardening with wildflowers. Site preparation and seed sowing will be explained, and the types of wildflowers that grow best in East Texas will be revealed. Learn how to enjoy a sequence of blooms, from the bluebonnets that bloom in spring, to the yarrow that blooms in fall, with native wildflowers that are beautiful, tough and beneficial to the local wildlife.

This is part of the Henderson County Master Gardeners Association (HCMGA) Learn at the Library Series. The series are free educational presentations are held on the third Tuesday of each month. For additional information please call 903-675-6130, e-mail hendersonCMGA@gmail.com, or visit http://www.henderson-co-tx-mg.org.

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Master Gardeners have scheduled presentations – Athens Daily Review

B61-12 continues to meet qualification test schedule – Los Alamos Monitor

B61-12 continues to meet qualification test schedule

The Department of Energys National Nuclear Security Administration and U.S. Air Force completed two qualification flight tests of B61-12 gravity bombs Aug. 8 at Tonopah Test Range in Nevada, the NNSA announced Monday.

The non-nuclear test assemblies, which were dropped from an F-15E based at Nellis Air Force Base in Nevada, evaluated the weapons non-nuclear functions and the aircrafts capability to deliver the weapon, NNSA officials said.

These tests are part of a series over the next three years to qualify the B61-12 for service.

The first qualification flight test occurred in March.

The B61 was designed and engineered by Los Alamos National Laboratory in 1963 and is the oldest type of nuclear weapon in the stockpile. The weapon is undergoing a life extension program at Los Alamos to convert four versions of the warhead into a single modification with a new tail kit for added accuracy, the B61-12.

If testing is successful, new version is scheduled to be produced in 2020.

The B61-12 life extension program is progressing on schedule to meet national security requirements, said Phil Calbos, acting NNSA deputy administrator for Defense Programs. These realistic flight qualification tests validate the design of the B61-12 when it comes to system performance.

The flight test included hardware designed by Sandia and Los Alamos national laboratories, manufactured by the Nuclear Security Enterprise plants, and mated to the tail-kit assembly section, designed by the Boeing Company under contract with the Air Force Nuclear Weapons Center.

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B61-12 continues to meet qualification test schedule – Los Alamos Monitor

The first men to conquer death will create a new social order a terrifying one – New Statesman

In a 2011 New Yorker profile, Peter Thiel, tech-philanthropist and billionaire, surmised that probably the most extreme form of inequality is between people who are alive and people who are dead. While he may not be technically wrong, Thiel and other eccentric, wealthy tech-celebrities, such as Elon Musk and Mark Zuckerberg, have taken the next step to counteract that inequality by embarking on a quest to live forever.

Thiel and many like him have been investing in research on life extension, part of transhumanism. Drawing on fields as diverse as neurotechnology, artificial intelligence, biomedical engineering and philosophy, transhumanists believe that the limitations of the human body and mortality can be transcended by machines and technology. The ultimate aim is immortality.Some believe thisis achievable by 2045.

Of course, humans have long harnessed technology, from vaccinations to smartphones, to improve and extend our lives. But that doesnt admit you into the transhumanist club. Wanting to live forever, and possessing vast sums of money and time to research, does.

The hows and whens of transhumanism are matters of debate. Some advocatethe “Singularity” a form of artificial super-intelligence which will encompass all of humanity’s knowledge, that our brains will then be uploaded to.Others believe in anti-ageing methods like cryonics, freezing your body after death until such a time when you can be revived.

Transhumanism is no longer a fringe movement either. Darpa, the US governments research arm into advanced weaponry, created a functional prototype of a super soldier exoskeleton in 2014, which will be fully functional in 2018, and is researching the possibility of an artificial human brain.

“Transhumanism doesn’t have much to say about social questions. To the extent that they see the world changing, it’s nearly always in a business-as-usual way techno-capitalism continues to deliver its excellent bounties, and the people who benefit from the current social arrangement continue to benefit from it,” says Mark O’Connell, the author of To be a Machine, who followed various transhumanists in Los Angeles.”You basically can’t separate transhumanism from capitalism. An idea that’s soenthusiastically pursued by Musk and Peter Thiel, and by the founders of Google, is one that needs to be seen as a mutationof capitalism, not a cure for it.”

Silicon Valley is characterised by ablind belief in technological progress,a disregard for social acceptability and an emphasis on individual success. It’s no surprise, then, that it is here that the idea of living forever seems most desirable.

Musk has publicly declared that we have to merge withartificially intelligent machines that overtake humanityin order to survive. Ray Kurzweil, the inventor and futurist who pioneered the Singularity, is now an engineer at Google. O’Connell points out that “you’d have to be coming from a particularly rarefied privilege to look at the world today and make the assessment, as someone like Thiel does, that the biggest problem we face as a species is the fact that people die of old age”.

On an even more basic level,a transhumanist society would undoubtedly be shaped by the ideals of those who created it and those who came before it. Zoltan Istvan, the transhumanist candidate for governor of California,toldTech Insiderthat a lot of the most important work in longevity is coming from a handful of the billionaires…around six or seven of them.

Immortality as defined by straight, white men could draw out cycles of oppression. Without old attitudes dying off and replaced by the impatience of youth, social change might become impossible. Artificial intelligence has already been shown to absorb the biases of itscreators. Uploading someones brain into a clone of themselves doesnt make them less likely to discriminate. Thiel andMusk, for example, identify as libertarians and have frequently suggested that taxes are obsolete and that governmental military spending needs to be curbed (and put into life-enhancing technologies).

Thiel himself is a Donald Trump supporter. A one-timeassociateMichael Anissimov, previousmedia officer at Machine Intelligence Research Institute, a Thiel-funded AI think tank, has published a white nationalist manifesto. In a 2013 interview, Anissimov said that there were already significant differences in intelligence between the races, and that a transhumanist society would inevitably lead to people lording it over others in a way that has never been seen before in history. It doesnt take much to guess who would be doing the “lording”.

“The first enhanced humans will not be ordinary people;they’ll be the people who have already made those ordinary people economically obsolete through automation. They’ll be tech billionaires,” says O’Connell.

If those who form society in the age of transhumanism aremen like Musk and Thiel, its probable that thissociety will have few social safety nets. There will be an uneven rate of technological progress globally; even a post-human society can replicate the unequal global wealth distribution which we see today. In some cities and countries, inhabitants maylive forever, while in others the residents die of malnutrition.If people dont die off, the environmental consequences from widespread natural resource devastation to unsustainable energy demands would be widespread.

It would be remiss to tar all transhumanists with one brush. In 2014, Istvan claimed inThe Huffington Postthat the membership of transhumanist societies and Facebook groups has started to expand in number and in diversity, drawing in young and old people of all political persuasions and nationalities.

There are some prominent transhumanists who dont fit into the Silicon Valley mould. Natasha Vita-More, the former Chairman of the Board of Directors of Humanity+ , the globaltranshumanist organisation, has spoken about the potential for a posthuman society to address issues of economic justice. Other academics and philosophers have even spoken about the need to explicitly ground diversity and tolerance within posthumanism, such as Nick Bostrom, the head of the Future of Humanity institute and one of the original modern transhumanist thinkers.

It remains the case, though, that the majority of the money invested inmaking transhumanism a reality comes from rich, white men. As the descendants of a species with a tendency to exploit thedowntrodden, any posthumans must guard against replicating thosesame biases in a new society. For some, potentially in the near future, death might become optional. For others, death will remain inevitable.

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The first men to conquer death will create a new social order a terrifying one – New Statesman

Global Naval Ship Modernization Assessment, Forecast to 2026 – PR Newswire (press release)

Countries have to maintain a large number of operational naval assets in order to build deterrence, protect sovereignty, and secure Sea Lines of Communication (SLOC). Operators are initiating comprehensive midlife upgrades and life extension programs in order to field adequate operational assets. The naval ship modernization market will grow at a compound annual growth rate (CAGR) of 4.3% during 20162026 and result in a total valuation of $49.10 billion. The market will be dominated by upgrades for surface combatant and submarine segments (92.5% of the total market).

Through this research service, Frost & Sullivan provides an assessment of global naval ship modernization programs, opportunities, forecasts, and technology trends from a macro level and also from a comprehensive micro-level countrywise assessment.

Key Target Audience

The key target audience includes: Defense OEMs and Integrators (especially their marketing and sales teams) Tier 1/ Tier 2/Tier 3 Suppliers Defense Consultants and Researchers Educational Bodies Personnel Working with Ministry/Department of Defense

Research ScopeThe market trends are analyzed for the study period 2016 to 2026, with the base year being 2016. The scope of the study is global, covering most nations which field a naval force.

The market is segmented across surface combatants, submarines, support ships, and patrol boats. Each segment is broken up into different vessel types and classes for granularity in information. Companies mentioned in the study include Lockheed Martin, Terma, Atlas Electronick, Raytheon, STM, TKMS, Kongsberg Marine, HII, and DCNS among others.

Country-specific modernization, life extension, and upgrade programs are arrived at using a combination of data including vessel acquisition and commissioning time frames, defense contract data, previous upgrades, defense spending patterns, and geopolitical exigencies.

Key Questions This Study Will Answer What are the committed, planned, and upcoming opportunities in the naval ship modernization market over the next 10 years? Which geographical markets and segments are growing? What are the key success factors that OEMs should consider in the market? What drives the need for modernizing naval ships in different nations and how do their procurement preferences and market dynamics differ? What are the major programs underway and planned within these markets and what opportunities do they open up for OEMs/contractors?Read the full report: http://www.reportlinker.com/p05075872/Global-Naval-Ship-Modernization-Assessment-Forecast-to.html

About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need – instantly, in one place.

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Global Naval Ship Modernization Assessment, Forecast to 2026 – PR Newswire (press release)

Competition to replace US nuclear missiles is down to 2 companies, but uncertainties remain – CNBC

The competition to replace America’s 1970s-era nuclear-tipped intercontinental ballistic missile program is now down to two large defense companies in a contract that the Air Force originally estimated would cost about $62 billion.

Yet there’s still a lot of uncertainty about the project, and its acquisition costs for taxpayers could go up to as much as $140 billion. Also, some critics of the program suggest we should just continue maintaining the current nuclear missiles as a deterrent for another decade to save money.

Regardless, the Air Force announced late Monday that Boeing and Northrop Grumman each won three-year contracts for the “technology maturation and risk reduction,” or essentially the preliminary design phase, of the Ground-Based Strategic Deterrent intercontinental ballistic missile weapon system program.

Lockheed Martin had been in the running, but it didn’t prevail.

GBSD is a modernization planned for the land-based Minuteman III, one leg of the nation’s nuclear triad land, sea and air-based capabilities.

Boeing was the prime contractor on the Minuteman III system, which dates back to 1970s and has been undergoing continued maintenance to keep it in service.

“It was an important win for Boeing,” Jefferies analyst Howard Rubel said in an interview. The analyst said Boeing’s defense business has suffered several setbacks in recent years, including losing the long-range strike bomber contact to Northrop and having problems with its aerial tanker program.

However, he said Boeing and Northrop each are now “competing to be the eventual prime contractor” on the GBSD program. “You went from three competitors to two. You went from what I call broad concepts to now, two competing designers, who will come up with an industrialization concept that will…probably have some testing done to prove certain points along the way.”

Boeing has yet to announce all of its partners in the GBSD program, and Northrop has announced some but not all.

Rubel said in a research note that he expects Orbital ATK and Aerjet Rocketdyne to also eventually get some work from the GBSD “as producers of large solid rocket motors. We expect the two companies to split the propulsion work in some fashion.”

This is the first of several phases in the contract process for the GBSD program, although the Pentagon isn’t expected to settle on a sole contractor for another few years. Production and then deployment aren’t expected until the late 2020s.

The two contracts announced Monday, valued at no more than $359 million apiece, are just a small portion of what the overall program will cost. The Pentagon’s independent cost assessment and program evaluation office last year upped the estimated acquisition cost to between $85 billion and about $140 billion.

“We are moving forward with modernization of the ground-based leg of the nuclear triad,” Secretary of the Air Force Heather Wilson said in a statement. “Our missiles were built in the 1970s. Things just wear out, and it becomes more expensive to maintain them than to replace them. We need to cost-effectively modernize.”

The modernization of the nation’s nuclear comes at a time when superpowers such as Russia and China are modernizing their weapons. Also there are rogue countries such as North Korea that also are a nuclear threat with missile development programs.

Even so, some have suggested that the nuclear weapon capability using bombers and submarines is a more effective deterrent because they are harder to detect and can be dispersed. The Trump administration is conducting a nuclear posture review that will debate whether the U.S. should maintain the triad.

Also, some critics of the GBSD program believe the Pentagon should keep the current Minuteman III missiles as a deterrent for at least another decade rather than replacing it right away.

“Sustaining the Minuteman III for a period of time (say 10-15 years) beyond 2030 would be cheaper than GBSD over that period,” said Reif Kingston, director of disarmament and threat reduction policy for the ACA. “The case for deferring a decision on GBSD and pursuing another life extension of the Minuteman III is strong.”

To be clear, Kingston said deferring the modernization would require a reduction, but not elimination, in the size of the current force of land-based nuclear ICBMs. “A smaller force would not diminish the overall strength and credibility of the U.S. nuclear deterrent,” he said.

Added Kingston, “We haven’t built a new intercontinental ballistic missile in decades. As the program proceeds, they will have start to get a better sense of the costs. But at this point, there’s a lot of uncertainty, and the Air Force’s estimate ($62 billion) by all accounts is unrealistically low.”

According to Kingston, a good portion of the data that the Air Force and others in the Pentagon had to work with to get an acquisition estimate on the Minuteman III replacement is “old and incomplete.”

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Competition to replace US nuclear missiles is down to 2 companies, but uncertainties remain – CNBC

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