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Archive for the ‘Skin Stem Cells’ Category

Fat grafting improves range of motion in limbs damaged by radiation therapy – Yahoo Finance

A new study released today in STEM CELLS outlines how fat grafting - which previous studies have shown can reduce and even reverse fibrosis (scar tissue) buildup - also improves the range of motion of the affected limb. The study, conducted by researchers at Stanford University School of Medicine, was conducted on mice.

DURHAM, N.C., Dec. 3, 2019 /PRNewswire-PRWeb/ --A new study released today in STEM CELLS outlines how fat grafting which previous studies have shown can reduce and even reverse fibrosis (scar tissue) buildup also improves the range of motion of the affected limb. The study, conducted by researchers at Stanford University School of Medicine, was conducted on mice.

The tumor-destroying capabilities of radiation therapy can be a life saver for a person suffering from cancer. But it's a therapy that has several unwanted side effects, too, including causing substantial damage not just to cancerous cells, but any healthy tissue in its path. Over time, fibrosis builds up in the treated area which, in the case of an arm, shoulder, or leg, for example, can lead to painful contractures that significantly limit extensibility and negatively impact the person's quality of life.

The Stanford team irradiated the right hind legs of subject mice, which resulted in chronic fibrosis and limb contracture. Four weeks later, the irradiated limbs of one group of the mice were injected with fat enriched with stromal vascular cells (SVCs). These potent cells already naturally exist in fat, but supplementation of fat with additional SVCs enhances its regenerative capabilities. A second group was injected with fat only, a third group with saline and a fourth group received no injections, for comparison. The animals' ability to extend their limb was then measured at baseline and every two weeks for a 12-week period. At the end of the 12 weeks, the hind limb skin underwent histological analysis and biomechanical strength testing.

"Each animal showed significant reduction in its limb extension ability due to the radiation, but this was progressively rescued by fat grafting," reported corresponding author Derrick C. Wan, M.D., FACS. Fat grafting also reduced skin stiffness and reversed the radiation-induced histological changes in the skin.

"The greatest benefits were found in mice injected with fat enriched with SVCs," Dr. Wan added. "SVCs are easily obtained through liposuction and can be coaxed into different tissue types, where they can support neovascularization, replace cells and repair injured issue.

"Our study showed the ability of fat to improve mobility as well as vascularity and appearance," he continued. "We think this holds enormous clinical potential especially given that adipose tissue is abundant and can be easily collected from the patients themselves and underscores an attractive approach to address challenging soft tissue fibrosis in patients following radiation therapy."

Furthermore, said co-author and world-renowned breast reconstructive expert Arash Momeni, M.D., FACS, "Our observations are potentially translatable to a variety of challenging clinical scenarios. Being able to reverse radiation-induced effects holds promise to substantially improve clinical outcomes in implant-based as well as autologous breast reconstruction. The study findings are indeed encouraging as they could offer patients novel treatment modalities for debility clinical conditions.

"Excessive scarring is a challenging problem that is associated with a variety of clinical conditions, such as burn injuries, tendon lacerations, etc. The potential to improve outcomes based on treatment modalities derived from our research is indeed exciting," Dr. Momeni added.

"Skin and soft tissue scarring and fibrosis are well-established problems after radiation. The current study, showing that human fat grafting can normalize the collagen networks and improve tissue elasticity in immune deficient mice, provides molecular evidence for how fat grafting functions," said Dr. Jan Nolta, Editor-in-Chief of STEM CELLS. "The studies indicate that, with the appropriate regulatory approvals, autologous fat grafting could potentially also help human patients recover from radiation-induced tissue fibrosis."

The full article, "Fat grafting rescues radiation-induced joint contracture," can be accessed at https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3115.

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About the Journal: STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. The journal covers all aspects of stem cells: embryonic stem cells/induced pluripotent stem cells; tissue-specific stem cells; cancer stem cells; the stem cell niche; stem cell epigenetics, genomics and proteomics; and translational and clinical research. STEM CELLS is co-published by AlphaMed Press and Wiley.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes three internationally renowned peer-reviewed journals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines. STEM CELLS (http://www.StemCells.com) is the world's first journal devoted to this fast paced field of research. THE ONCOLOGIST (http://www.TheOncologist.com) is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. STEM CELLS TRANSLATIONAL MEDICINE (http://www.StemCellsTM.com) is dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

About Wiley: Wiley, a global company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical and scholarly journals, combined with our digital learning, assessment and certification solutions, help universities, learned societies, businesses, governments and individuals increase the academic and professional impact of their work. For more than 200 years, we have delivered consistent performance to our stakeholders. The company's website can be accessed at http://www.wiley.com.

SOURCE STEM CELLS

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Fat grafting improves range of motion in limbs damaged by radiation therapy - Yahoo Finance

Novadip Biosciences to present data at 17th Annual Meeting of the International Federation for Adipose Therapeutics and Science – GlobeNewswire

Novadip Biosciences to present data at 17th Annual Meeting of the International Federation for Adipose Therapeutics and Science

Mont-Saint Guibert, Belgium, 4 December, 2019: Novadip Biosciences (Novadip or the company), a clinical-stage biopharmaceutical company leveraging its unique tissue regeneration technology platform to generate multiple product candidates, announces that it is presenting data in a series of presentations at the 17th Annual Meeting of the International Federation for Adipose Therapeutics and Science (IFATS) taking place in Marseille, France, from 4-7 December 2019.

Dr Denis Dufrane, Chief Scientific Officer and co-founder, Novadip, commented: The findings that will be presented at IFATS highlight the capabilities of Novadips 3-dimensional, scaffold-free extracellular matrix (ECM) technology platform utilizing adipose-derived stem cells (ASCs) to generate product candidates to address critical size bone and skin reconstruction, as well as our manufacturing capabilities and expertise. We look forward to progressing our clinical programmes and generating further data in support of our unique platform as we look to address hard and soft tissue reconstruction for patients who have limited or no treatment options.

Novadip will deliver five oral presentations and one video presentation. Details of the presentations and short summaries are below.

Genetic stability assessment in bone tissue-engineered productsCline Pierard, oral presentation #8 (abstract 1395), 5 December 2019, 8:38 am CET

The presentation will discuss the different analytical approaches to predict the genetic behavior over the entirety of the manufacturing process for the companys product candidates for bone reconstruction.

A scaffold-free graft for large critical size bone defect: preclinical evidence to clinical proof of conceptSophie Veriter, video presentation #V5 (abstract 1363), 5 December 2019, 2:48 pm CET

The session will discuss how the scaffold-free 3D-graft (comprised of ASCs) plays a major role promoting ASCs engraftment and to induce osteogenesis in a fibrotic environment and promote bone fusion in a critical-sized bone defect.

The in vivo immunogenicity of a human 3D scaffold-free tissue engineered product for bone reconstruction: a xenogenic modelGatan Thirion, oral presentation #30 (abstract 1382), 5 December 2019, 4:30 pm CET

Detail will be provided on how the human scaffold-free 3D approach, in a xenogenic model, can elicit a specific anti-human immune response but can maintain the potential of in vivo osteogenicity.

An allogenic 3D scaffold-free tissue engineered product for deep thickness skin regeneration: in vitro development to in vivo proof of conceptSophie Veriter, oral presentation #88 (abstract 1317), 6 December 2019, 5:50 pm CET

The presentation will discuss how the scaffold-free approach with the allogenic 3D-graft (derived from ASCs) demonstrated safety and efficacy in a stringent xenogenic model of hyperglycemic and ischemic deep-thickness wound.

Allogenic 3D scaffold-free tissue engineered product for deep thickness skin regeneration: in vitro characterization and in vivo biocompatibilityValrie Lebrun, oral presentation #90 (abstract 1341), 6 December 2019, 6:06 pm CET

The presentation will provide an overview on how the allogenic scaffold-free 3D-graft improves ASC bioactivity for the angiogenesis and in vivo remodeling by the specific ECM-proteins of wound healing.

Monitoring of cell culture conditions and early prediction of the quality of an osteogenic cell-based medicinal productAnas Namur, oral presentation #136 (abstract 1392), 7 December 2019, 2:44 pm CET

The session will describe how cellular metabolism was studied throughout the companys manufacturing process to better understand the physiology of the proliferative and differentiated cells and subsequently develop predictive tests focused on critical attributes of the final product.

To view the full abstracts, please follow this link.

The full list of abstracts can be found here. Further information on IFATS is available here.

- Ends -

Notes to editors

Novadip Biosciences

Novadip Biosciences is a clinical stage biopharmaceutical company leveraging its unique 3D tissue regeneration technology platform to generate multiple product candidates to address hard and soft tissue reconstruction for patients who have limited or no treatment options. The companys proprietary 3M3 platform is a 3-dimensional, extracellular matrix that utilizes adipose-derived stem cells to deliver highly-specific growth factors and miRNA to mimic the physiology of natural healing and creates a range of products that address specific challenges in tissue regeneration. Novadips initial focus is on critical size bone reconstruction and its lead program is in development for a rare pediatric orthopedic disease. The company is also applying its 3M3 platform to develop truly novel off-the-shelf/allogeneic therapies to address more prevalent tissue defects. For more information, visit http://www.novadip.com .

For further information, please contact:

Novadip Biosciences

Jeff Abbey

Chief Executive Officer

+32 (10) 779 220

info@novadip.com

For media enquiries:

Consilium Strategic Communications

Chris Gardner, Matthew Neal, Angela Gray

+44 (0) 20 3709 5700

novadip@consilium-comms.com

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Novadip Biosciences to present data at 17th Annual Meeting of the International Federation for Adipose Therapeutics and Science - GlobeNewswire

Dr Sister Ltd Offers Effective Skin Treatments to Both Men and Women – The News Front

Dr Sister Ltd continues to offer effective skin treatments to both men and women, and they have been doing this for over 45 years now. Doctor Sister provides a comprehensive portfolio of treatments while at the same time delivering natural-looking, regenerative and enhancing results for the face and body. They are big believers in helping slow down the ageing process for each client, as of course, they are unable to stop time for you.

At Dr Sister Ltd, you can be treated by a professional doctor that trains other practitioners. Dr Sisterhimself has introduced over ten ground-breaking treatments to the UK market, along with eight published books, many articles in international peer reviews medical journals and general press, as well as being one of UKs and Europes leading lecturer and trainer in the field of Aesthetic Medicine.

The treatments offered by Dr Sister Ltd are non-invasive so there is no surgery and no downtime. Some of the skin treatments on offer at Dr Sister Ltd include the following; mini face lift, non-surgical face lift, vampire facial, PRP treatment and PRP injection. That is not an exhaustive list and he is also a renowned hormonal expert.

Dr. Sister has perfected safe, effective, natural-looking treatments, which has made him a worldwide expert and teacher in regenerative and innovative procedures such as Dracula PRP, Mint Lift including the new Stem Cell Facelift.

The PRP treatment (Dr. Sister has his own superior trademarked version called Dracula Therapy) may be unfamiliar to some clients. Dr Sister explains the procedure in great detail on their site. APRP treatment is a powerful anti-ageing treatment that involves using your blood as an injectable treatment (PRP Injection). Dr Daniel Sister was the first to introduce the treatment into the UK, and now he calls it Dracula Therapy.

With the Dracula Therapy or vampire facial, you will notice results within 3-4 weeks, and often only one PRP injection is required. However, the treatment may need to be repeated every 2-6 months because of the on-going ageing process.

The PRP injections generally appeal to patients looking for a more natural approach to facial rejuvenation, which is the rejuvenation process of using their cells. This treatment does not use synthetic fillers or animal products and has no risks or side effects.

At Dr Sister Ltd, they are well known for their aesthetic treatments, in particular, the MINT lift and Dr Sister is the training partner for the MINT lift. It is a PDO thread lift that offers exceptional results. Dr. Sister has been particularly impressed by the results as it provides an immediate and obvious lift, which many of his patients are looking for.

Dr Sister Ltd also mentions that local anaesthetic is used making the procedure pain free, and patients generally return to work and usual activities the following day. There are many benefits such as soft tissue lifting, instant lift, results lasting around 18 months.

If you would like to find out more about the treatments on offer at Dr Sister Ltd, there are many ways to get in touch. You can email press@drdanielsister.com your query, and they will get back to you as soon as possible, or you can go online to their website at https://drdanielsister.com. On their site, you will find all the information about the top treatments, fees, testimonials, and Dr Sister Ltd.

Source:https://thenewsfront.com/dr-sister-ltd-offers-effective-skin-treatments-to-both-men-and-women/

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Dr Sister Ltd Offers Effective Skin Treatments to Both Men and Women - The News Front

Induced Pluripotent Stem Cells Market To Register High Revenue Growthat 7% CAGR Throughout 2018 to 2026 – Kentucky Reports

The healthcare industry has been focusing on excessive research and development in the last couple of decades to ensure that the need to address issues related to the availability of drugs and treatments for certain chronic diseases is effectively met. Healthcare researchers and scientists at the Li Ka Shing Faculty of Medicine of the Hong Kong University have successfully demonstrated the utilization of human induced pluripotent stem cells or hiPSCs from the skin cells of the patient for testing therapeutic drugs.

The success of this research suggests that scientists have crossed one more hurdle towards using stem cells in precision medicine for the treatment of patients suffering from sporadic hereditary diseases. iPSCs are the new generation approach towards the prevention and treatment of diseases that takes into account patients on an individual basis considering their genetic makeup, lifestyle, and environment. Along with the capacity to transform into different body cell types and same genetic composition of the donors, hiPSCs have surfaced as a promising cell source to screen and test drugs.

In the present research, hiPSC was synthesized from patients suffering from a rare form of hereditary cardiomyopathy owing to the mutations in Lamin A/C related cardiomyopathy in their distinct families. The affected individuals suffer from sudden death, stroke, and heart failure at a very young age. As on date, there is no exact treatment available for this condition. This team in Hong Kong tested a drug named PTC124 to suppress specific genetic mutations in other genetic diseases into the iPSC transformed heart muscle cells. While this technology is being considered as a breakthrough in clinical stem cell research, the team at Hong Kong University is collaborating with drug companies regarding its clinical application.

The unique properties of iPS cells provides extensive potential to several biopharmaceutical applications. iPSCs are also used in toxicology testing, high throughput, disease modeling, and target identification. This type of stem cell has the potential to transform drug discovery by offering physiologically relevant cells for tool discovery, compound identification, and target validation. A new report by Persistence Market Research (PMR) states that the globalinduced pluripotent stem or iPS cell marketis expected to witness a strong CAGR of 7.0% from 2018 to 2026. In 2017, the market was worth US$ 1,254.0 Mn and is expected to reach US$ 2,299.5 Mn by the end of the forecast period in 2026.

Customization to be the Key Focus of Market Players

Due to the evolving needs of the research community, the demand for specialized cell lines have increased to a certain point where most vendors offering these products cannot depend solely on sales from catalog products. The quality of the products and lead time can determine the choices while requesting custom solutions at the same time. Companies usually focus on establishing a strong distribution network for enabling products to reach customers from the manufacturing units in a short time period.

Entry of Multiple Small Players to be Witnessed in the Coming Years

Several leading players have their presence in the global market; however, many specialized products and services are provided by small and regional vendors. By targeting their marketing strategies towards research institutes and small biotechnology companies, these new players have swiftly established their presence in the market.

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Induced Pluripotent Stem Cells Market To Register High Revenue Growthat 7% CAGR Throughout 2018 to 2026 - Kentucky Reports

Sales of the Stem Cell Therapy Market to Anticipated to Exceed US$ XX by 2017 – 2025 – Markets Gazette 24

TMRR, in its recent market report, suggests that the Stem Cell Therapy market report is set to exceed US$ xx Mn/Bn by 2029. The report finds that the Stem Cell Therapy market registered ~US$ xx Mn/Bn in 2018 and is spectated to grow at a healthy CAGR over the foreseeable period. This Stem Cell Therapy market study considers 2018 as the base year, 2019 as the estimated year, and 2019 2029 as the forecast timeframe.

The Stem Cell Therapy market research focuses on the market structure and various factors (positive and negative) affecting the growth of the market. The study encloses a precise evaluation of the Stem Cell Therapy market, including growth rate, current scenario, and volume inflation prospects, on the basis of DROT and Porters Five Forces analyses. In addition, the Stem Cell Therapy market study provides reliable and authentic projections regarding the technical jargon.

Important regions covered in the Stem Cell Therapy market research include Region 1 (Country 1, country 2), Region 2 (Country 1, country 2), Region 3 (Country 1, country 2) and Region 4 (Country 1, country 2).

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The Stem Cell Therapy market study answers critical questions including:

The content of the Stem Cell Therapy market report includes the following insights:

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On the basis of component, the global Stem Cell Therapy market report covers the following segments:

Key Trends

The key factors influencing the growth of the global stem cell therapy market are increasing funds in the development of new stem lines, the advent of advanced genomic procedures used in stem cell analysis, and greater emphasis on human embryonic stem cells. As the traditional organ transplantations are associated with limitations such as infection, rejection, and immunosuppression along with high reliance on organ donors, the demand for stem cell therapy is likely to soar. The growing deployment of stem cells in the treatment of wounds and damaged skin, scarring, and grafts is another prominent catalyst of the market.

On the contrary, inadequate infrastructural facilities coupled with ethical issues related to embryonic stem cells might impede the growth of the market. However, the ongoing research for the manipulation of stem cells from cord blood cells, bone marrow, and skin for the treatment of ailments including cardiovascular and diabetes will open up new doors for the advancement of the market.

Global Stem Cell Therapy Market: Market Potential

A number of new studies, research projects, and development of novel therapies have come forth in the global market for stem cell therapy. Several of these treatments are in the pipeline, while many others have received approvals by regulatory bodies.

In March 2017, Belgian biotech company TiGenix announced that its cardiac stem cell therapy, AlloCSC-01 has successfully reached its phase I/II with positive results. Subsequently, it has been approved by the U.S. FDA. If this therapy is well- received by the market, nearly 1.9 million AMI patients could be treated through this stem cell therapy.

Another significant development is the granting of a patent to Israel-based Kadimastem Ltd. for its novel stem-cell based technology to be used in the treatment of multiple sclerosis (MS) and other similar conditions of the nervous system. The companys technology used for producing supporting cells in the central nervous system, taken from human stem cells such as myelin-producing cells is also covered in the patent.

Global Stem Cell Therapy Market: Regional Outlook

The global market for stem cell therapy can be segmented into Asia Pacific, North America, Latin America, Europe, and the Middle East and Africa. North America emerged as the leading regional market, triggered by the rising incidence of chronic health conditions and government support. Europe also displays significant growth potential, as the benefits of this therapy are increasingly acknowledged.

Asia Pacific is slated for maximum growth, thanks to the massive patient pool, bulk of investments in stem cell therapy projects, and the increasing recognition of growth opportunities in countries such as China, Japan, and India by the leading market players.

Global Stem Cell Therapy Market: Competitive Analysis

Several firms are adopting strategies such as mergers and acquisitions, collaborations, and partnerships, apart from product development with a view to attain a strong foothold in the global market for stem cell therapy.

Some of the major companies operating in the global market for stem cell therapy are RTI Surgical, Inc., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc., NuVasive, Inc., Pharmicell Co., Ltd., Anterogen Co., Ltd., JCR Pharmaceuticals Co., Ltd., and Holostem Terapie Avanzate S.r.l.

All the players running in the global Stem Cell Therapy market are elaborated thoroughly in the Stem Cell Therapy market report on the basis of R&D developments, distribution channels, industrial penetration, manufacturing processes, and revenue. In addition, the report examines, legal policies, and comparative analysis between the leading and emerging Stem Cell Therapy market players.

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Sales of the Stem Cell Therapy Market to Anticipated to Exceed US$ XX by 2017 - 2025 - Markets Gazette 24

Autologous Stem Cell and Non-Stem Cell Based Therapies Market 2019 by Technology (Neurodegenerative Diseases, Cardiovascular Diseases, Cancer and…

Autologous Stem Cell and Non-Stem Cell Based Therapies Market 2019 Industry Research Report gives vital information then analytical data of Autologous Stem Cell and Non-Stem Cell Based Therapies Market Size, Share, Growth, Key Players then forecast. Furthermore it provides development trends and marketing channels analysis. Finally the feasibility of new investment projects are assessed and overall research conclusions offered. This report also presents product specification, manufacturing process, and product cost structure.

You can get a sample copy of this report at https://www.orianresearch.com/request-sample/1380754

Autologous stem-cell transplantation is autologous transplantation of stem cells in which stem cells are removed from an individual, stored, and later given back to that same individual.

The Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market was estimated to be valued at USD XX million in 2018 and is projected to reach USD XX million by 2026, at a CAGR of XX% during 2019 to 2026. The increase in chronic diseases is one of the chief factors supplementing the market growth. Conversely, the lack of awareness regarding the potential benefits of stem cells might hamper the market growth.

The global autologous stem cell and non-stem cell based therapies market is segmented on the basis of technology and region. Based on technology the market is segmented into neurodegenerative diseases, cardiovascular diseases, cancer and autoimmune diseases, skin transplantation and infectious disease. Based on region, it is studied across North America Europe, Asia-Pacific, South America and Middle East and Africa.

Inquire more or share questions if any before the purchase on this https://www.orianresearch.com/enquiry-before-buying/1380754 The key players profiled in the market include:* Antria* Bioheart* Brainstorm Cell Therapeutics* Cytori* Dendreon Corporation* Fibrocell* Genesis Biopharma* Georgia Health Sciences University* Neostem* Opexa Therapeutics

The report offers the market growth rate, size, and forecasts at the global level in addition as for the geographic areas: Latin America, Europe, Asia Pacific, North America, and Middle East & Africa. Also it analyses, roadways and provides the global market size of the main players in each region. Moreover, the report provides knowledge of the leading market players within the Autologous Stem Cell and Non-Stem Cell Based Therapies Market. The industry changing factors for the market segments are explored in this report. This analysis report covers the growth factors of the worldwide market based on end-users.

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On the basis of technology, the market is split into:* Neurodegenerative Diseases* Cardiovascular Diseases* Cancer and Autoimmune Diseases* Skin Transplantation* Infectious Disease

Table of Contents:

Global Autologous Stem Cell and Non-Stem Cell Based Therapies Industry Market Research Report

1 Autologous Stem Cell and Non-Stem Cell Based Therapies Introduction and Market Overview

2 Industry Chain Analysis

3 Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market, by Type

4 Autologous Stem Cell and Non-Stem Cell Based Therapies Market, by Application

5 Global Autologous Stem Cell and Non-Stem Cell Based Therapies Production, Value ($) by Region (2014-2019)

6 Global Autologous Stem Cell and Non-Stem Cell Based Therapies Production, Consumption, Export, Import by Regions (2014-2019)

7 Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market Status and SWOT Analysis by Regions

8 Competitive Landscape

9 Global Autologous Stem Cell and Non-Stem Cell Based Therapies Market Analysis and Forecast by Type and Application

10 Autologous Stem Cell and Non-Stem Cell Based Therapies Market Analysis and Forecast by Region

11 New Project Feasibility Analysis

12 Research Finding and Conclusion

13 Appendix

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Autologous Stem Cell and Non-Stem Cell Based Therapies Market 2019 by Technology (Neurodegenerative Diseases, Cardiovascular Diseases, Cancer and...

100 greatest innovations of 2019: Best of What’s New – Popular Science

Within days of giving birth, a womans estrogen and progesterone levels quickly drop, leading to chemical changes in the brain that might give rise to shifts in mood. In fact, as many as three in four mothers experience symptoms of depression soon after childbirth. But for one in nine mothers, those symptoms result in a more serious, longer-lasting, and potentially life-threatening condition known as postpartum depression. The disorder, which manifests as a significant change in mood within hours to weeks of giving birth, is the most common complication of pregnancy. Currently, the depression drugs used to treat it take weeks to months to kick intime that new mothers (and their infants) cant afford. Zulresso is the first FDA-approved medication designed to tackle postpartum depression, and it does so at speed. The drug is a synthetic form of allopregnanolone, a hormone that dampens neural activity and eases depression symptoms when estrogen and progesterone levels dip. In double-blind control studies run by the creators at Sage Therapeutics, Zulresso worked within 60 hours. Right now, the drug is administered via a 60-hour intravenous infusion (common among new medicines), but alternative treatments, including a pill form, are currently in clinical trials.

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100 greatest innovations of 2019: Best of What's New - Popular Science

Study Finds This Medication May Reduce Wrinkles & Even Skin Tone – mindbodygreen.com

Collagen seems to be one of the buzziest words in wellness, with just about anyone's ears perked up at the mention of the wordno matter how young they are. Because when it comes to healthy skin aging, we know that prevention is everything, and delaying the process before it starts is key to maintaining a smooth, even complexion well into the autumn of life.

Enter all the collagen-promoting creams, serums, supplements, and diets the world has to offerand now, a new drug may be just the trick.

A new study published in the journal GeroScience found a new, unexpected formula to help with healthy aging. This specific drugcalled rapamycinhas been primarily used for patients who have undergone an organ transplant, as it helps prevent the immune system from rejecting the new organ. Rapamycin has also been used to combat a rare lung disease called lymphangioleiomyomatosis, as well as inhibiting tumor growth.

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Study Finds This Medication May Reduce Wrinkles & Even Skin Tone - mindbodygreen.com

Seven Products Our Beauty Editor Used to the Last Drop – Sarasota

When it comes to our beauty and skincare products, it's easy for years to pass without an updateor even an upgrade. But because advances in beauty technology are happening at the speed of light, its always important to pause and reassesswhat we're usingfrom dog shampoo to stem-cell skincare. SoI've rounded up the best of the latest trends that have earned a place inmymakeup bag.

Its no secret that Ima major fan of Kjaer Weisthere is something utterly fresh and clean about everything for the face and body, and its as organic as it can get. Enter the latest additions to the line: the cleanser ($95) and toner ($85, both pictured above). Not only does the soft, gel-like cleanser effectively remove all makeup, but its also calming. Follow it with a quick spritz of the toner and you have hydrated and re-balanced skin. Plus, the scents aredreamy.If I could accurately describe them, I would. But I was in Bluemercury downtown recently they have sample bottles to give it a go yourself.Bluemercury, 1500 Main Street, Sarasota. (941) 365-0020

Two things on my must-do-better list: Sunscreen and preventing this neck from aging. Addressing the first, Alastin Skincares HydraTint Pro Mineral Sunscreen SPF 36 ($55) is a revelation. Not only is it lightweight, with broad-spectrum UVA/UVB sun protection, it also protects against environmental pollution and it has a universal tint that enhances most skin tones. Its the first thing Iput on in the morning before taking the dogs for a walk; I love the just-right tinted coverage.

Second, that neck thing. As much as I prefer organic and natural skincarewhen possible, I tend to lean on science for combatting aging. Enter: Nectifirm Advanced ($133). Its next-gen technology based on the ecosystem of the skins microbiome, plus eight peptides that helps skin appear firmer and lifted while lessening the appearance of lines and wrinkles. Not to mention that those in the know at Sarasota Facial Aesthetics rave about the results. Get both products atSarasota Facial Aesthetics,1806 South Osprey Avenue,(941) 955-8384.

I was of the mind that a razor is a razoris a razor. Well, thats changed since theFlamingo razor($9.99) came on my radar. The team raised the bar on shaving after spending years talking to women (what a concept!) who shared the nuances of their personal care rituals and how typical razors fell short. Use this once and it will be clear that they did not overlook those edges of our bodies that need extra attention.Target, 101 N. Cattlemen Road, (941) 360-7520

Speaking of: here's another kind of sunscreen, this time for the eye area. Who knew? I recently discovered Colorescience Total Eye3-in-1 Renewal Therapy SPF 35 ($74)they say it visibly improves the appearance of dark circles, puffiness, fine lines and wrinkles, while protecting the delicate eye area against photoaging with 100 percent SPF 35 mineral sunscreen. I say its great coverage, and if it comes with all of those benefits then...yay!L. Spa, 556 Pineapple Ave., (941) 906-1358

Brace yourself (and maybe your credit card) because Augustinus Baders The Cream ($265) is right there at the cutting edge for stem cell skincare. Get this: the stem cells found in skin lie dormant, awaiting an activation signal to repair the damage inflicted by life and environmental factors.The patented technology TFC8Bader's proprietary "Trigger Factor Complex"is comprised of natural amino acids, high-grade vitamins and synthesized molecules that are found naturally in the skin. Its a repairing force in an ultra-lightweight cream that guides key nutrients and powerful natural ingredients to the skin cells, creating an optimal environment for the body's innate processes of repair and renewal.Thats a lot, but all I know is that I can see the results after a lotta life has happened to my skin. Its crazy good, and I guess for the price it should be. Saks Fifth Avenue, 120 University Town Center Drive, Sarasota. (941) 364-5300

Lastly, this one is for the love of our fur kids, especially those with sensitive skin. The Malin + Goetz Dog Shampoo ($28) is infused with natural botanical amino acids to gently cleanse fur and skin without drying, stripping or irritating. And I can attest that fur dries soft and oh-so-shiny. Malin + Goetz, malinandgoetz.com

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Seven Products Our Beauty Editor Used to the Last Drop - Sarasota

Heres How Niacinamide Benefits Your Complexion (and How to Work It into Your Skin Care Routine) – Yahoo Lifestyle

Were always happy to geek out over a buzzyskin careingredient when we see it making the rounds on product labels. (See: lactic acid, rosehip oil, bakuchiol) So when we started noticing the proliferation of niacinamide, we were surprised to learn that not only has it been around for a while buttheres a decent body of research behind the multipurpose vitamin. Heres what you need to know about niacinamidesbenefits for your skin.

Niacinamide, a form of vitamin B3 also known as nicotinamide, is a water-soluble vitamin that has potent antioxidant activity and reduces inflammation, saysboard-certified dermatologistDavid Lortscher, CEO of Curology.

It would be an exaggeration to call niacinamide a cure-all, but it does have a pretty extensive range when it comes to the conditions it can treat: acne, oil regulation, fine lines and wrinkles, hyperpigmentation, enlarged pores and sun damage. Its especially good at repairing skins moisture barrier (aka its first line of defense) and protecting against environmental stressorsits even been shown to help prevent skin cancer in certain studies.

Niacinamides nourish and calm redness and inflammation,says DendyEngelman, a board-certified dermatologist in New York. She particularly likes niacinamide for dry and sensitive skin: It has similar effects to retinol by strengthening the skin barrier, but itfortifies from the get-go without sensitivity or irritation.Dr. Lortscher also has high praise: Because of its role in repairing the skin barrier, niacinamide is one of the most effective treatments for photoaging [damage caused by UV rays], according to most anti-aging research.

It starts to get technical here, but as Dr. Engelman explains it, Niacinamide helps support the cellsmetabolic system, specifically fibroblasts. We use fibroblasts tomake and repair DNA,which,in turn, activates collagen production. So by using niacinamides to boost fibroblast production, we are supporting collagen production and repairing damaged collagen.

Lots of products contain niacinamideserums, moisturizers, even cleansersand it works well in conjunction with other active ingredients, like retinol. It can be used both morning and night, though as with any goodskin careregimen, you should follow it up with a sunscreen during the day.

Niacinamide should be compatible with most otherskin careproducts and is well tolerated by all skin types,including sensitiveskin, Dr. Lortscher says. For best results, use leave-on products with niacinamide. Its safe to use around the eyes, anditmay improve the appearance of under-eye darkness and wrinkles.

Convinced yet? Check out a few of our favorite products containing the powerhouse ingredient below.

RELATED: We Ask a Derm: What Ingredients Should You Avoid If You Have Oily Skin?

Of course, the uber-popular, wallet-friendly brand is on top of it. This serum is especially helpful for congested, acne-prone skin: The niacinamides anti-inflammatory propertiescalm active breakouts, while its oil-regulating properties (and the addition of zinc, which also keeps oil in check) help keep new ones from forming.

Buy it ($6)

Nia 24 uses a patented form of niacinamide thats designed to absorb better into skin (and therefore work its magic more effectively). This rich cream strengthens the skin barrier with its namesake ingredient, plus hyaluronic acid, licorice root extract, peptides and ceramides.

Buy it ($118)

Give parched, dull skin a quick pick-me-up with a five-star-rated gel sheet mask. Reviewers rave about its glow-inducing, hydrating properties and the fact that its gentle enough for sensitive skin.

Buy it ($3)

Cursed by the ghosts of pimples past? Niacinamide, glycolic acid and NASA-developed plant stem cells (!) work together to combat hyperpigmentation and scarring.

$20 on Amazon

Derms, dry-skinned gals and makeup lovers alike know oil cleansers are a godsend forwashing off the days makeup withoutstripping any precious natural moisture. This cleanser amps up the effects with niacinamides barrier-strengthening effects, plus offers a gentle exfoliation thanks to fruit enzyme.

Buy it ($42)

SkinCeuticals serums are cult faves for a reason, and this 5 percent niacinamide serum is no exception. Its amped up with amino acids, algae extract and peptides to target the effects of environmental stress and promote collagen production.

Buy it ($112)

RELATED: The Best Face Moisturizer for Dry, Sensitive Skin, According to People Who Use Them

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Heres How Niacinamide Benefits Your Complexion (and How to Work It into Your Skin Care Routine) - Yahoo Lifestyle

Makeup brand offers spray-on ‘skin’ to cover up zits and scars – FOX 10 News Phoenix

Soon youll be able to cover your imperfect flesh with more flesh. (Photo: KaoJapan)

FOX NEWS - Soon youll be able to cover your imperfect flesh with more flesh.

Japanese cosmetics company Kao Corporation has developed a custom synthetic spray-on skin to cover unwanted blemishes, moles or other marks on the natural epidermis.

READ MORE ON FOXNEWS.COM

The artificial product, called est, is composed of tiny, liquid fibers. When sprayed, the substance adheres to human skin, transforming into an extremely thin, derma-like material, the Daily Mail reports.

It has a similar elasticity to skin, and its porous, too. Water vapor and air can pass through this second skin to moisten the living dermis beneath. At its edges, est forms an even thinner bond, helping it blend in with natural flesh.

Est is set to hit the market exclusively in Japan beginning Dec 4. and will sell for roughly $532 as a diffuser and potion combination, with diffuser refills priced at $73. A lotion version will sell for $110, and everything will become available online in January, according to Japanese publication the Asahi Shimbun.

Japanese-language advertisements for the product call it Future Skin, which uses Fine Fiber Technology. Kao has plans to expand the line beginning next year and hopes to soon enter the medical market.

Until then, American consumers can check out the SkinGun by RenovaCare, which shoots a liquid mist infused with human stem cells and can help burn victims skin.

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Makeup brand offers spray-on 'skin' to cover up zits and scars - FOX 10 News Phoenix

How birds fly: New USC study examines the evolution of flight feathers – USC News

Birds of a feather may flock together, but the feathers of birds differ altogether.

New research from an international team led by USC scientists set out to learn how feathers developed and helped birds spread across the world. Flight feathers, in particular, are masterpieces of propulsion and adaptation, helping penguins swim, eagles soar and hummingbirds hover.

Despite such diversity, the feather shares a common core design: a one-style-fits-all model with option trims for specialized performance. This simplicity and flexibility found in nature holds promise for engineers looking for better ways to build drones, wind turbines, medical implants and other advanced materials.

Those findings, published today in Cell, offer an in-depth look at the form and function of a feather based on a comparative analysis of their physical structure, cellular composition and evolution. The study compares feathers of 21 bird species from around the world.

Weve always wondered how birds can fly in so many different ways, and we found the difference in flight styles is largely due to the characteristics of their flight feathers, said Cheng-Ming Chuong, the studys lead author and a developmental biologist in the Department of Pathology at the Keck School of Medicine of USC. We want to learn how flight feathers are made so we can better understand nature and learn how biological architecture principles can benefit modern technology.

To gain a comprehensive understanding of the flight feather, Chuong formed a multi-disciplinary international team with Wen Tau Juan, a biophysicist at the Integrative Stem Cell Center, China Medical University in Taiwan. The work involved experts in stem cells, molecular biology, anatomy, physics, bioimaging, engineering, materials science, bioinformatics and animal science. The bird species studied include ostrich, sparrow, eagle, chickens, ducks, swallow, owl, penguin, peacock, heron and hummingbird, among others.

They compared feathers using fossils, stem cells and flight performance characteristics. They focused on the feather shaft, or rachis, that supports the feather much like a mast holds a sail, bearing the stress between wind and wing. They also focused on the vane, the lateral branches astride the shaft that give the feather its shape to flap the air. And they examined how evolution shaped the barbs, ridges and hooks that help a feather hold its form and lock with adjacent feathers like Velcro to form a wing. The goal was to understand how a simple filament appendage on dinosaurs transformed into a three-level branched structure with different functions.

We want to learn how flight feathers are made so we can better understand nature and learn how biological architecture principles can benefit modern technology.

Cheng-Ming Chuong

For birds such as ducks, eagles and sparrows that fly in different modes, the scientists noted significant differences in the feather shaft compared to ground-hugging birds. On the rigid exterior, the shaft cortex was thinner and lightweight, while the interior was filled with porous cells resembling bubble wrap, aligned into bands of various orientations and reinforced with ridges that operate like tiny lateral beams. Together, it forms a light, hollow and buoyant structure to enable flight. Cross-sections of feather shafts of different birds show highly specialized shapes and orientations of the inner core and outer cortex.

The flight feather is made of two highly adaptable architectural modules, light and strong materials that can develop into highly adaptable configurations, Chuong said.

The researchers discovered two different molecular mechanisms guiding feather growth. Cortex thickness was governed by bone morphogenetic proteins, which are molecular signals for tissue growth. The porous feather interior, or medulla, relied upon a different mechanism known as transforming growth factor-beta (TGF-b). Both components originate as stem cells in the birds skin.

By contrast, feathers in flightless birds were simpler, consisting of a dense cortex exterior that is more rigid and sturdy with fewer internal struts and cells found in flying birds. The features were especially pronounced for penguins, which use wings as paddles under the water.

As part of the study, the researchers looked at 100 million-year-old feathers, found embedded in amber in Myanmar. These fossils show early feathers lacked one key feature that modern birds have. Specifically, the researchers report that fossil feathers had barb branches and barbules, which form a feather vane by overlapping, but not hooklets. The hooklets, which act like clasps to turn fluffy feathers into a tight flat plane for high-performance flight, evolved later. The scientists also identified WNT2B, another growth factor, as the agent that controls hooklet formation. These also originated from epidermal stem cells.

Taken together, the findings show how feathered dinosaurs and early birds could form a primitive vane by overlapping barbule plates, although that wasnt aerodynamically fit to carry much load. As more complex composite features occurred in the wing, it got heavier, so feather shafts became stronger yet more lightweight, which led to stiffer feathers and sturdy wings that powered flight to carry birds around the world.

Our findings suggest the evolutionary trends of feather shaft and vane are balanced for the best flight performance of an individual bird and become part of the selective basis of speciation, the study said. The principles of functional architectures we studied here may also stimulate bio-inspired designs and fabrication of future composite materials for architectures of different scales, including wind turbines, artificial tissues, flying drones.

Chuong and Juan are co-leaders of the 31-person team, joined by co-authors Randall B. Widelitz, Shuo Wang, Michael Habib, Ting-Xin Jiang, Zhong-Lai Luo and Ping Wu of the Keck School of Medicine of USC; Wei-Ling Chang, Hao Wu, Yung-Chi Lai, Ming Xing Lei, and Shih-Chieh Hung of the China Medical University Hospital in Taiwan; Ming-You Shie, Jui-Ting Hsu, Heng-Li Huang and Yi-Wen Chen of the China Medical University, Taiwan; Chih-Feng Chen, Ping Chi Tang, Hus Chen Cheng, and Yen-Cheng Lin of the National Chung Hsing University in Taiwan; How-Jen Gu, Yu-Kun Chiu, Tse-Yu Lin, Shun-Min Yang, Tsung-Tse Lee, J.C. Tsai and Yeu-Kuang Hwu of the Institute of Physics, Academia Sinica, Taiwan; Cheng-Te Yao of the Endemic Species Research Institute, Taiwan; Shyh-Jou Shieh of the National Cheng Kung University, Taiwan; Ang Li of the University of Texas, Arlington.

Work at USC was supported by the National Institutes of Health (AR 047364, AR 060306) while team members in Taiwan were supported by grants from their own institutes and the Taiwan government.

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How birds fly: New USC study examines the evolution of flight feathers - USC News

Production growth strengthens in November but remains subdued: IHS Markit – ANI News

ANI | Updated: Dec 02, 2019 12:06 IST

New Delhi [India], Dec 2 (ANI): Although business conditions in the Indian manufacturing sector improved in November, the upturn remained subdued compared to earlier in the year and the survey history, according to IHS Markit India Manufacturing Purchasing Managers' Index (PMI) released on Monday.Growth rates for new orders and production were modest despite accelerating from October's recent lows while firms shed jobs for the first time in 20 months and continued to reduce input buying.At the same time, there were only slight increases in input costs and output prices halfway through the third quarter of fiscal year 2019-20.The headline seasonally adjusted IHS Markit India Manufacturing PMI rose from 50.6 in October, when it had fallen to a two-year low, to 51.2 in November. The latest reading was below the survey average (53.8) and indicated only a slight improvement in the health of the sector.Consumer goods provided the main impetus to overall growth while the intermediate goods category returned to expansion territory. Conversely, there was a solid deterioration in operating conditions at capital goods makers.Indian manufacturing production increased only moderately in November, albeit at a quicker rate than October's two-year low.Anecdotal evidence suggested that growth was supported by the launch of new products and better demand, though restrained by competitive pressures and unstable market conditions.Total sales increased for the 25th month in a row with growth strengthening from October's recent low. Besides, the upturn was among the weakest over this sequence.Some firms were able to secure new work amid successful marketing and strengthening demand, but others struggled in the face of competitive conditions, a challenging economic scenario and troubles in the automotive sector.Manufacturers were partly helped by external markets as signalled by a further expansion in international sales. The increase in exports was slight, however, and among the weakest over the past year-and-a-half."PMI data continued to show a lack of inflationary pressures in the sector which, combined with slow economic growth, suggests that the Reserve Bank of India will likely extend its accommodative policy stance and further reduce the benchmark interest rate during December," said Principal Economist at IHS Markit Pollyanna de Lima.Subdued sales prevented hiring in November with payroll numbers declining for the first time in 20 months. A number of companies indicated that workloads had been managed by existing staff while others cited the non-replacement of retirees and non-renewal of temporary contracts.Firms also scaled back input purchasing, with the latest decline the fourth in as many months. Subsequently, the current sequence of falling stocks of purchases that started in August was extended to November.Rates of contraction for both input buying and inventories were marginal, said IHS Markit.The IHS Markit India Manufacturing PMI is compiled from responses to questionnaires sent to purchasing managers in a panel of around 400 manufacturers. The panel is stratified by detailed sector and company workforce size, based on contributions to GDP.IHS Markit is a world leader in critical information, analytics, and solutions for the major industries and markets that drive economies worldwide. The company delivers next-generation information, analytics, and solutions to customers in business, finance, and government. (ANI)

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Production growth strengthens in November but remains subdued: IHS Markit - ANI News

Mucopolysaccharidoses: future therapies and perspectives – SciTech Europa

Mucopolysaccharidoses (MPS) are a group of very rare disorders, also known as orphan diseases. They belong to the group of lysosomal storage diseases which are caused by a deficiency of one of the enzymes involved in the degradation of mucopolysaccharides (the acid glycosaminoglycans or GAGs). The enzymes are coded by genes which produce deficient gene products due to gene variants in each of the two gene-alleles.

Children of two carriers as parents have a 25% risk to suffer from MPS. For many families, the birth of the first affected child is a shock and a disaster. The disease is continuously progressing, and life spans are dramatically decreased without therapy. As a result, extensive efforts are put into the cure of these fatal disorders.

Enzymes are relatively small proteins, produced in the endoplasmatic reticulum of each cell. Before reaching the locus of their function, the lysosomes, additional modifications with special sugars are performed in the Golgi apparatus (glycosylation). Via mannose-6-phosphate marker, they connect to the mannose-6-phosphat receptor on the lysosomal membrane and can reach the final locus of their function. In the lysosomes, enzymes degrade the GAG chains into the smallest molecules for recycling or excretion. Any disturbance in this process leads to the accumulation of non-degraded material, which affects many other cell functions such as homeostasis, calcium metabolism, accelerates apoptosis and induces inflammation processes.

As lysosomes are ubiquitous, any disturbance leads to storage in many different tissues and organs. MPSs are a good example for chronic progressive multi-systemic disorders. The best theoretical option for treatment of any patient is to supplement the missing enzyme which could reach any organ via blood flow and get inside the lysosomes continuing the interrupted degradation processes.

The enzymes are ubiquitous and have some tissue specific compositions. Enzymes produced in the different cells and tissues have their own characteristics and are available on site. The production of recombinant enzymes means that the artificial glycosylation is created in a uniform composition for intravenous substitution with the aim to reach the organs with the blood-flow. There is no doubt that the therapeutic efficacy is ideal for many organs, such as liver, spleen, lung, and skin. All these organs have a good blood circulation and some ability to regenerate.

However, after years of treatment with the already available enzymes, it is shown that some organs are poorly supplied with blood and renewal cycles are slow, the ability to regenerate is decreased. Organs such as bones, cartilage, muscles, cornea, heart valves, meninges or the brain do not show the hope-for effect. All MPS types with brain involvement (neuronopathic forms of MPS types I, II and VII) or predominant skeletal dysplasia (MPS types IVA and B) cannot benefit from enzyme-replacement therapy and do not show the desired improvement.

In animal studies, modifications of glycosylation can change the ability to pass into organs not yet sufficiently reached such as cartilage or bones, but tissue-specific features cannot be sufficiently considered in any artificial production of the enzymes.

Avascular cartilage, heart valves and corneas cannot be reached by blood flow. Also, between blood vessels and brain tissue, several specialised cells form the blood-brain-barrier (BBB) to protect the brain from any unwanted substances in the blood. Therefore, new strategies are necessary to improve the therapeutic efficiency and to provide better outcomes for the affected patients. If patients with MPS I are diagnosed at a very young age, the best option is to treat them with haematopoietic stem cell transplantation (HSCT). Migrating stem cells can reach the brain and other organs, and then differentiate into organ-specific cells producing the missing lysosomal enzymes.

A straightforward method to overcome BBB is the direct injection of a recombinant enzyme into the cerebral fluid. This can be by lumbar puncture (intra-thecal) or intra-ventricular injections in the brain ventricles. Effects can be observed, however unfortunately not all challenges can currently be solved. The liquor flow can be reduced by thickened meninges with storage and vertebral deformities, which are typical for the disease. However, the barrier between cerebral fluid and brain tissue has still not been fully studied. The half-life of enzymes is limited, and the procedure has to be repeated regularly. The clinical trials for patients with MPS I, II, IIIA and IIIB could show some reduced or reversed progression of CNS pathology but long-term effects remain unclear.

Another possibility to overcome BBB is to fuse the enzyme proteins with macromolecules which enter the brain through receptor mediated active transport systems. This physiological transport is known for hormones, neurotransmitters and many other proteins (such as transferrin and insulin). They are transported through the BBB directly into the brain via specific receptores, so, the strategy is to fuse the natural proteins with the artificial enzymes needed in the MPS patient. It is important to note that clinical trials could potentially still show some improvement in affected MPS patients.

Another method is to conjugate the therapeutic enzymes with nano-capsules and to then ferry them across BBB via transcytosis or other transport mechanisms directly into brain cells. Pharmacological chaperones have been proven to be effective in other lysosomal storage diseases such as Gaucher or Fabry disease. Chaperones are able to stabilise three-dimensional conformation of misfolded proteins, such as enzymes. This would be the case of genetic variants causing missense mutation and exchange of only one amino acid in the protein chain. The misfolding pathology reduces stability, half-life and effect of the genetically conditioned enzyme, whereas the chaperone can reverse this disadvantage and increase the activity and efficacy of the enzyme. As a result, pharmacological chaperones are a good option for some diseases and could therefore be an option for some MPS patients in the future.

Some genetic variants cause stop-codons and the production of truncated dysfunctional peptides without any enzymatic activity and degradation within the cell. Stop-codon read through therapy aims for the genetic correction on an RNA level, resulting in the production of a sufficiently functioning gene product. It is already used for some specific mutation for patients with Duchenne muscular dystrophy, but it is too early to predict positive results for patients with MPS I.

Another possibility in the future might be the use of GAG-reducing small molecules such as Genistein, Pentosam polysulfate or Rhodamine B. They are able to influence and/or reduce the synthesis of GAGs which cannot be degraded sufficiently by the genetically changed enzymes with reduced function.

To reduce the GAGs as substrate, could be a chance to create a better relation between substrate and the impaired substrate reducing enzyme. As a result, lysosomal storage could therefore be reduced. Substrate reduction therapy is an established therapeutic concept in some of the other lysosomal storage diseases, but the usefulness in MPS disorders still needs to be proven.

The genetic corrections of DNA sequences in patient cells are no longer only future options as they have now become a reality. Gene variants causing missing or impaired functioning gene products could be replaced by correct genetic sequences and genes. This can be made as an ex vivo approach, where stem cells or fibroblast are removed from the patient and are then cultured in vitro, genetically corrected and consecutively re-injected into the patient.

The genetically corrected DNA in the re-transplanted autologous cells is able to produce correct gene products (in terms of MPS, this is the specific enzyme). The amounts of newly produced enzymes might be sufficient to positively influence the disease course of the treated patients.

An in vivo approach utilises viral vectors which invade cells, and even cell nuclei. Such viruses used are adeno-associated-viruses or lenti-viruses. Such manipulated viruses with the corrective genetic material are directly injected into the patient where they are internalised into deficient cells and are then able to produce the missing gene product. In the case of MPS, the aim is to produce enzyme proteins with sufficient concentrations and activity to prevent the storage of GAGs. Furthermore, clinical trials are underway for several MPS types and therefore, might offer a therapeutic opportunity in early life for affected patients. However, larger studies and a longer follow-up is still needed.

To conclude, MPS are rare genetic disorders and for a long time, they were linked with the myth of being untreatable diseases. Although some of the new therapeutic options are still in clinical trials and not routinely used, the present shows that many of the patients can benefit from the yet available options of HSCT and enzyme replacement therapies. These therapies have an undoubted effect for some of the MPS patients, especially if any form of therapy is started early or if the course of the disease does not affect the nervous system.

However, in the future, new therapeutic options will hopefully bring benefits to those that are not sufficiently improved; the decision of the best therapy will be made on the basis of factors such as the genetic defect, the type of MPS, and the age during treatment. This individualised and personalised therapy will improve the success of MPSs therapies.

Susanne Gerit KircherMedical University of Vienna, AustriaCenter of Pathobiochemistry and Geneticssusanne.kircher@meduniwien.ac.atwww.mps-austria.at

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Mucopolysaccharidoses: future therapies and perspectives - SciTech Europa

Scientists create drugs to keep the skin youthful by boosting levels of a crucial protein – Stock Daily Dish

Saggy, wrinkled faces could soon be a thing of the past as researchers have identified a key mechanism of how skin ages.

A key protein compound which could represent a new anti-ageing intervention has been discovered by scientists.

Two drugs have been created which offer hope that a fountain of youth could be developed in the future.

The drugs work by boosting levels of a certain protein, which is found in high levels in young skin cells, but begins to dwindle over time as we age.

When the levels of this protein drop, skin cells appear older, misshapen and less elastic.

They also appear thinner and become more blotchy and more fragile.

As long as lots of cells are being born deep below the surface of the skin with high levels of the protein, the skin appears youthful.

In a survival of the fittest scenario, these healthier skin cells out-compete the weaker ones, which go on to die.

But over time, fewer strong skin cells are born and the weaker ones take over, creating a wrinkly appearance to the skin.

In addition, stress, such as exposure to toxic chemicals, or sun damage can also reduce levels of the protein, called COL17A1.

But giving hope to anyone who wishes for a more youthful appearance, researchers said they have found a way to boost its levels.

As well as recreating youthful looks, the drugs have potential to help wound healing and even to prevent skin cancer, the researchers suggest.

Emi Nishimura, from Tokyo Medical and Dental School, and colleagues made the discovery in mice and in human skin tissue grown in the laboratory.

The compounds have yet to be tested on living humans.

Writing in the journal Nature, the authors said they discovered two chemical compounds that boosted COL17A1.

The chemicals, Y27632 and apocynin, when applied to the skin, significantly promoted wound repair by boosting the production of skin cells with high levels of COL17A1, the authors wrote.

The discovery points towards directions for facilitating skin regeneration and reducing skin ageing, they said.

Commenting on the discovery, Ganna Bilusova and James DeGregori, both of the University of Colorado, suggest that the discovery may also help prevent tumours forming.

They wrote, the maintenance of fit stem cells through the years in which an individual is likely to reproduce probably also prevents tumour development, because these fit cells compete with (and eliminate) both damaged stem cells and tumour-prone cells.

They added that the work provides evidence that healthy cells in mammals can also efficiently repopulate adult tissues, replacing unfit or damaged cells.

Both chemicals improve wound healing in mouse tail skin, providing a proof-of-principle demonstration of the therapeutic potential of this new class of drug.

The development also points the way to regenerate other organs apart from the skin, Professor Bilusova and Professor DeGregori wrote.

Future studies are needed to determine the mechanisms of cell competition in other tissues, and to identify compounds capable of reversing ageing in other organs.

Wrinkles are creases, folds, or ridges in the skin.

They normally appear as people get older, but they can also develop after spending a long time in water.

The first wrinkles to appear on a persons face tend to occur as a result of facial expressions.

A tendency to laugh, frown or glare in a certain way can amplify creases in particular regions.

Laughter lines and crows feet tend to be formed from smiling and forehead furrows originate from frowning.

Sun damage, smoking, dehydration, some medications, and environmental and genetic factors also affect when and where people will develop wrinkles.

Most wrinkles tend to appear in the parts of the body which receive the most sun exposure, especially the face and neck, the back of the hands, and the arms.

The upper layer of skin has to renew regularly as it is made of dead cells.

As you get older, it takes longer for your epidermis to renew itself and it shows more and more signs of your age.

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Scientists create drugs to keep the skin youthful by boosting levels of a crucial protein - Stock Daily Dish

Makeup brand offers spray-on ‘skin’ to cover up zits and scars – New York Post

Soon youll be able to cover your imperfect flesh with more flesh.

Japanese cosmetics company Kao Corporation has developed a custom synthetic spray-on skin to cover unwanted blemishes, moles or other marks on the natural epidermis.

The artificial product, called est, is composed of tiny, liquid fibers. When sprayed, the substance adheres to human skin, transforming into an extremely thin, derma-like material, the Daily Mail reports.

It has a similar elasticity to skin, and its porous, too. Water vapor and air can pass through this second skin to moisten the living dermis beneath. At its edges, est forms an even thinner bond, helping it blend in with natural flesh.

Est is set to hit the market exclusively in Japan beginning Dec 4. and will sell for roughly $532 as a diffuser and potion combination, with diffuser refills priced at $73. A lotion version will sell for $110, and everything will become available online in January, according to Japanese publication the Asahi Shimbun.

Japanese-language advertisements for the product call it Future Skin, which uses Fine Fiber Technology. Kao has plans to expand the line beginning next year and hopes to soon enter the medical market.

Until then, American consumers can check out the SkinGun by RenovaCare, which shoots a liquid mist infused with human stem cells and can help burn victims skin.

Kao Japan

Kao Japan

Kao Japan

Kao Japan

Kao Japan

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Makeup brand offers spray-on 'skin' to cover up zits and scars - New York Post

AVITA Medical Teams With Gates Center to Advance Therapeutic Skin Restoration – CU Anschutz Today

AVITA Medical (ASX: AVH, NASDAQ: RCEL), a regenerative medicine company with a technology platform positioned to address unmet medical needs in therapeutic skin restoration, and scientists at the Gates Center for Regenerative Medicine at the University of Colorado School of Medicine have announced a preclinical research collaboration to establish proof-of-concept and explore further development of a spray-on treatment of genetically modified cells for patients with epidermolysis bullosa (EB), with potential applicability to other genetic skin disorders.

The partnership will pair AVITA Medicals patented and proprietary Spray-On Skin Cells technology and expertise with the Gates Centers innovative, patent pending combined reprogramming and gene editing technology to allow cells to function properly. Under the terms of the Sponsored Research Agreement (SRA), AVITA Medical retains the option to exclusively license technologies emerging from the partnership for further development and commercialization. The Gates Center team is further supported by the EB Research Partnership in New York, the Los Angeles-based EB Medical Research Foundation, the London-based Cure EB Charity and government grants, in a collaborative effort to rapidly develop and translate this technology to the clinic for meaningful impact on patient lives.

The Gates Center is a leader in developing therapeutic approaches for genetic skin diseases. Researchers at the Gates Center have developed a powerful new approach for treating genetic skin disorders and improving the lives of patients with epidermolysis bullosa, said Mike Perry, PhD, chief executive officer of AVITA Medical and adjunct professor at the Gates Center for Regenerative Medicine. We look forward to collaborating with the team at the Gates Center on the expanded use of our technology. This agreement marks an important milestone in AVITAs mission to harness the potential of regenerative medicine to address unmet medical needs across a broad range of dermatological indications, including genetic disorders of the skin.

Epidermolysis bullosa is a group of rare and incurable skin disorders caused by mutations in genes encoding structural proteins resulting in skin fragility and blistering, leading to chronic wounds and, in some sub-types, an increased risk of squamous cell carcinoma or death. There are no approved curative therapies, and current treatment is palliative - focused primarily on pain and nutritional management, itching relief, wound care, and bandaging.

Its very exciting to partner with AVITA Medical to help advance our epidermolysis bullosa program, said Director of the Gates Center for Regenerative Medicine Dennis Roop, PhD. Were looking forward to exploring a novel approach to delivering gene-edited skin cells to patients that addresses current treatment challenges.

We believe that Spray-On Skin Cells technology combined with our genetically corrected cells has the potential to be game changing in the treatment of this disease. This combination could reduce time to treatment, lower manufacturing complexity, reduce costs and improve patient outcomes, said Ganna Bilousova, PhD, assistant professor of dermatology, who is a co-principal investigator on this research program.

ABOUT THE CHARLES C. GATES CENTER FOR REGENERATIVE MEDICINE

The Charles C. Gates Center for Regenerative Medicine was established in 2006 with a gift in memory of Denver industrialist and philanthropist, Charles C. Gates, who was captivated by the hope and benefit stem cell research promised for so many people in the world. The Gates Center aspires to honor what he envisionedby doing everything possible to support the collaboration between basic scientific researchers and clinical faculty to transition scientific breakthroughs into clinical practice as quickly as possible.

Led by Founding Director Dennis Roop, PhD, the Gates Center is located at the University of Colorados Anschutz Medical Campus, the largest new biomedical and clinical campus in the United States. Operating as the only comprehensive Stem Cell Center within a 500-mile radius, the Gates Center shares its services and resources with an ever-enlarging membership of researchers and clinicians at the Anschutz Medical Campus, which includes University of Colorado Hospital, Childrens Hospital Colorado and the Veterans Administration Medical Center, as well as the Boulder campus, Colorado State University, the Colorado School of Mines, and business startups. This collaboration is designed to draw on the widest possible array of scientific exploration relevant to stem cell technology focused on the delivery of innovative therapies in Colorado and beyond.

ABOUT THE UNIVERSITY OF COLORADO SCHOOL OF MEDICINE

Faculty at the University of Colorado School of Medicine work to advance science and improve care. These faculty members include physicians, educators and scientists at University of Colorado Hospital, Childrens Hospital Colorado, Denver Health, National Jewish Health, and the Denver Veterans Affairs Medical Center. The school is located on the CU Anschutz Medical Campus, one of four campuses in the University of Colorado system. To learn more about the medical schools care, education, research and community engagement, visit its web site.

ABOUT AVITA MEDICAL LIMITED

AVITA Medical is a regenerative medicine company with a technology platform positioned to address unmet medical needs in burns, chronic wounds, and aesthetics indications. AVITA Medicals patented and proprietary collection and application technology provides innovative treatment solutions derived from the regenerative properties of a patients own skin. The medical devices work by preparing a REGENERATIVE EPIDERMAL SUSPENSION (RES), an autologous suspension comprised of the patients skin cells necessary to regenerate natural healthy epidermis. This autologous suspension is then sprayed onto the areas of the patient requiring treatment.

AVITA Medicals first U.S. product, the RECELL System, was approved by the U.S. Food and Drug Administration (FDA) in September 2018. The RECELL System is indicated for use in the treatment of acute thermal burns in patients 18 years and older. The RECELL System is used to prepare Spray-On Skin Cells using a small amount of a patients own skin, providing a new way to treat severe burns, while significantly reducing the amount of donor skin required. The RECELL System is designed to be used at the point of care alone or in combination with autografts depending on the depth of the burn injury. Compelling data from randomized, controlled clinical trials conducted at major U.S. Burn Centers and real-world use in more than 8,000 patients globally, reinforce that the RECELL System is a significant advancement over the current standard of care for burn patients and offers benefits in clinical outcomes and cost savings. Healthcare professionals should read the INSTRUCTIONS FOR USE - RECELL Autologous Cell Harvesting Device (https://recellsystem.com/) for a full description of indications for use and important safety information including contraindications, warnings and precautions.

In international markets, our products are marketed under the RECELL System brand to promote skin healing in a wide range of applications including burns, chronic wounds and aesthetics. The RECELL System is TGA-registered in Australia and received CE-mark approval in Europe.

To learn more, visit http://www.avitamedical.com.

Photo at top: From left, Igor Kogut, PhD, Ganna Bilousova, PhD, and Dennis Roop, PhD.

Guest contributor: Gates Center for Regenerative Medicine/ASX

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AVITA Medical Teams With Gates Center to Advance Therapeutic Skin Restoration - CU Anschutz Today

New Link Discovered Between Cells That Burn Fat and Colon Cancer – Clinical OMICs News

A new study by Rutgers University researchers suggests that two genes expressed in the intestinal cells that line the inside of the colon may also be involved in cancer development.

Recent studies have shown that intestinal stem cells can increase in animals on a high fat Western diet, potentially explaining an elevated cancer risk from such a diet.Diet being able to control cell proliferation is an interesting research development, particularly the convergence of dietary factors and dysregulated gene signaling driving malignant transformations and promoting an adenoma-to-adenocarcinoma progression.

This new study suggests a novel connection between HNF4A and HNF4G genes, diet and cancer.Genetic expression of HNF4 has previously been shown by to be heavily influenced by the gut microbiota, which in turn can influence a multitude of intestinal disorders.

Non-host gene regulation was further explored in this study by using a high fat diet to test how these genes work, and the researchers discovered they help co-regulate stem cell proliferation, as well as help intestine cells burn dietary fat. This was done by isolating cells from knockout and control mice and observing intestine stem cell proliferation under conditions of high fat and control. Mice that had both HNF4A and HNF4G knocked out were unable to have their stem cells proliferate under high fat conditions.

Intestinal stem cells undergo constant renewal and fuel the continuous turnover of the lining of the intestine. People naturally lose millions of intestinal cells daily, much like they lose skin cells. If this rate of replication is not closely controlled, it can quickly lead to malignancy. Lack of proliferation can be very problematic for the colon and damaging to lower layers of cells.

This [research] is important because scientists have shown that when theres too much dietary fat in the intestine, stem cell numbers increase, boosting susceptibility to colon cancer, said senior author Michael Verzi, an associate professor in the Department of Genetics in the School of Arts and Sciences at Rutgers UniversityNew Brunswick.

Rutgers scientists believe HNF4A and HNF4G help stem cells burn fat, providing them energy. By linking gene activation, cell replication number, diet and cancer risk, scientists might be able to better understand the cancer development process in high risk patients. Going forward, the researchers plan to continue studying whether these two genes alter stem cell numbers and cancer risk alongside a high fat diet, said Verzi.

Colorectal cancer (of the colon or rectum) is the third most common cancer diagnosed in both men and women in the United States. According to the American Cancer Society, over 100,000 Americans will be diagnosed with colon cancer this year. This cancer is also the second most deadliest in the United States, but due to a combination of increased screening and heightened awareness the death rate has been dropping. However, in patients under the age of 55, the death rate of colon cancer has increased each year by 1% since 2007. Approximately 50,000 colon cancer patients are expected to die in 2019.

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New Link Discovered Between Cells That Burn Fat and Colon Cancer - Clinical OMICs News

Augustinus Bader The Cream Review: Why It’s Worth Every Cent – Glamour

The most raved about secret in beauty this year wasn't a magic facialist or Real Housewife-lauded injection, it was an unassuming moisturizer made by a 60-year-old German scientist who'd never worked in the industry, let alone had an Instagram following. And yet, despite having none of the traditional resources that makes a beauty brand an overnight successlike paid celebrity spokespeople, $1 million ad campaigns, or millennial pink packagingAugustinus Bader became a sleeper hit purely through word of mouth.

In the nearly two years since it launched, AB's "miracle cream" has gotten accolades from Ashley Graham, Kate Bosworth, and Victoria Beckham (who's since launched a moisturizing primer with the brand). Glamour even gave it a Beauty Award for Best Moisturizer, a highly competitive category as you can surely imagine. So before I even uncapped the weighty blue-and-copper tube of its famed The Cream, which costs a cool $265 for 50 mL, I was basically set to fall in love with itprice tag be damned.

But the only kind of hype I pay real attention to is beauty editor hype; if my product-inundated colleagues are raving about it, I figure it has to stand out from the pack. And for weeks, every single editor I knew had told me about the cream in an attitude I can only describe as reverent. I was ready to experience my own Bader-sparked miracle.

Bizarrely, I didn't immediately fall head over heels for it (don't worry, a second plot twist will follow shortly). Sure, it was a good face cream. The light texture absorbed quickly and my skin looked decent, but it didn't exactly wow me. I felt like a thin layer just wasn't doing much in the moisturizing departmentwhich, apparently, I later learned isn't even what The Cream claims to do. It's more of an overall skin rejuvenator. The brand also sells a Rich Cream for dry skin, which contains additions like avocado and argan oil to aide with extra hydration, but I began with the original thinking it'd be enough.

In order to get maximum effectiveness from the active ingredients, I did what a few other friends and makeup artists had advised and skipped all other products, except face wash. The Bader formula is based on TFC8 (Trigger Factor Complex 8), a proprietary cocktail of over 40 different ingredients, including vitamins and amino acids. It's meant to encourage regeneration and healingProfessor Bader actually discovered the formula while looking for solutions to help burn survivors heal quickerand TFC8 is supposed to activate your stem cells, which go to work to repair fine lines, dark spots, and visible pores. I had heard that the ingredients within were enough to replace all other skin care, so I devoted myself to a one-step kind of lifestyle and waited for my skin to start looking like I had just walked out of a spa. And then I waited some more...

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Augustinus Bader The Cream Review: Why It's Worth Every Cent - Glamour

The best skincare to shop this Black Friday – harpersbazaar.com

Harper's Bazaar

This year, Black Friday has truly become a behemoth, with every retailer from Liberty to Net-A-Porter offering a bevy of tempting discounts.

Unsurprisingly, its easy to become overwhelmed and succumb to those impulse buys - especially when just-reduced lipsticks and buzzy fragrance bottles are winking at you from every angle.

But the smartest shoppers will tackle the Black Friday sales with a discerning eye. That luxury eyeshadow palette might make a sparkling addition to your festive party looks, but an expertly formulated serum has the power to transform your skin for good.

Here, discover the eight most sensible, editor-approved skincare purchases you can (and should) make this Black Friday. After all, glowing, healthy skin is for life not just for Christmas.

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1Black Rose Cream Mask

110.00

WAS 110 NOW 99

Sisley's legendary skincare is rarely reduced, so the savviest shoppers will be stockpiling.

Where to start? It has to be the universally adored, deep-hydrating Black Rose Cream Mask, which has the power to bring the driest of skin back to its glowing former glory.

2Enzyme Cleanser

50.00

SAVE UP TO 30%

Dr. Barbara Sturm's results-driven skincare is used by so many of the world's best facialists.

If you're new to the brand, begin with the deeply clarifying Enzyme Cleanser, then fall in love with the cult Hyaluronic Serum.

The discount you will receive at Cult Beautydepends on the value of your bag: spend 75 to receive 20% off, 200 for 25%, and 500 for a remarkable 30% reduction.

3Luna Sleeping Night Oil

SUNDAY RILEYselfridges.com

WAS 85 NOW 76.50

Sunday Riley's cult Luna oil isn't the most potent retinol on the shelves, but it is one of the most soothing. Working to refine pores while nurturing a nourished glow, it'll make a brilliant addition to any night-time skin routine.

4Ultimate Cleanse

48.00

WAS 48 NOW 43.20

One of the UK's best facialists, Sarah Chapman knows exactly how to create a winning cleanser. This peptide-powered balmreally can do it all: sweep away remnants of make-up, dissolve pollutants, and leave skin happy and balanced. Try it, and be converted.

5Protect Elixir

93.50

WAS 110 NOW 93.50

It may have only launched in September, but Decree has quickly become one of our most-loved skincare lines.

Formulated by dermatologist Dr. Anita Sturnham, the collection of cleansers, serums and SPF creams is designed to deliver everything your skin needs and nothing it doesn't.

The Protect Elixir is a worthy starting point packed with vitamins, hyaluronic acid and powerful antioxidants, it's the only daytime serum you'll need.

6Moisturizing Cream

301.75

WAS 355 NOW 301.75

If you're loyal to La Mer's legendary skincare, now's the time to stock up.

Thanks to Harvey Nichols, you can save 15% across the entire line, from the iconic Moisturizing Cream to the best-selling Treatment Lotion.

7The Rich Cream 50ml

Augustinus Baderharveynichols.com

WAS 205 NOW 174.25

Thisboundary-pushing cream is the result of 30 years of research and innovation, and it's undoubtedly worth the hype.

Originally created for burns victims, Augustinus Bader's The Cream contains a Trigger Factor Complex, which worksto boost the natural healing process of the body's stem cells. The result? A unified complexion almost instantly, with plumped-up lines and firmer skin following in a few weeks.

8C-Tango Multivitamin Eye Cream

54.00

SAVE UP TO 30%

A shopping spree can be salubrious, especially when you're stocking up on Drunk Elephant's globally adored skincare.

But not only will such a haul be good for your complexion it'll benefit your wallet too. Spend 300 on Cult Beauty this weekend, and you'll save a remarkable 30%.

On our list? The transformative C-Tango Multivitamin Eye Cream, alongside a bottle of the B-Hydra intensive Hydration Serum:a saviour in these cold climes.

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The best skincare to shop this Black Friday - harpersbazaar.com

Global Stem Cell Therapy Market Industry Demand, Scope and Strategic Outlook, Growth Analysis, Business Opportunities and Future Scope till 2025 -…

Global Stem Cell Therapy Market,By Type (Allogeneic Stem Cell Therapy, Autologous Stem Cell Therapy), Product (Adult Stem Cells, Human Embryonic Stem Cells, Induced Pluripotent Stem Cells), Applications (Musculoskeletal Disorders, Wounds, Injuries, Cardiovascular Diseases, Surgeries, Gastrointestinal Diseases, Other Applications), End Users (Therapeutic Companies, Cell And Tissues Banks, Tools And Reagent Companies, Service Companies), Geography (Asia North America, South America, Europe, Asia-Pacific, Middle East And Africa) Industry Trends and Forecast to 2025

Market Analysis: Global Stem Cell Therapy Market

The Global Stem Cell Therapy Market is expected to reach USD 15.63 billion by 2025, from USD 7.72 billion in 2017 growing at a CAGR of 9.2% during the forecast period of 2018 to 2025. The upcoming market report contains data for historic year 2016, the base year of calculation is 2017 and the forecast period is 2018 to 2025.

Request for Sample:https://www.databridgemarketresearch.com/request-a-sample?dbmr=global-stem-cell-therapy-market

Market Definition: Global Stem Cell Therapy Market

Stem cell therapy is the therapy which uses stem cells for the treatment or prevention of a disease. Bone marrow transplant is the widely applicable therapy which is followed by umbilical cord blood. Research is going on to develop various sources (such as cord blood cells, bone marrow and skin) to use these cells for treatment of various disorders like neurodegenerative diseases and conditions such as heart disease, diabetes and other conditions.

For instance, according to published article, in 2014, Regenerative Medicine reported 4749 registries of clinical trials related to stem cell treatment.

In 2017,According to National Institutes of Health, the department was funded US$ 1,644 million for stem cell research. For instance, according to the center for disease and control US, in 2015, Sickle cell disease (SCD) is the most common severe genetic disease. It impacts approximately 7,000 people in California and nearly 90,000 in the U.S.

The growing prevalence of chronic diseases and increasing investments of pharmaceutical and biopharmaceutical companies in stem cell research are the key factors for the growth of the stem cells therapeutics market.

Major Market Drivers and Restraints:

Drivers:

Restraints:

Market Segmentation: Global Stem Cell Therapy Market

Key Developments in the Market:

Competitive Analysis: Global Stem Cell Therapy Market

The global stem cell therapy market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of the global stem cell therapy market for global, Europe, North America, Asia Pacific and South America.

Request for TOC:https://www.databridgemarketresearch.com/toc?dbmr=global-stem-cell-therapy-market

Major Market Competitors/Players: Global Stem Cell Therapy Market

Some of the major players operating in the global stem cell therapy market are Osiris Therapeutics, Inc. (U.S.), MEDIPOST Co., Ltd. (South Korea), Anterogen Co., Ltd. (South Korea), Pharmicell Co., Ltd. (South Korea), STEMCELL Technologies Inc., Astellas Pharma Inc., Cellular Engineering Technologies Inc., BioTime Inc., Takara Bio Inc., U.S. Stem Cell, Inc., BrainStorm Cell Therapeutics Inc., Caladrius Biosciences, Inc., Athersys., Cytori Therapeutics, Inc., Fate Therapeutics Inc., Geron Corporation., Pluristem Therapeutics Inc., Thermo Fisher Scientific., Vericel Corporation., ViaCyte, Inc, AbbVie, Mesoblast Ltd., Roslin Cells, Regeneus Ltd, ReNeuron Group plc,, International Stem Cell Corporation, Aastrom Biosciences, Inc., Advanced Cell Technology, Cryo Cell International, Cytori Therapeutics, Inc., Geron Corporation, and Invitrogen and others.

Research Methodology: Global Stem Cell Therapy Market

Data collection and base year analysis is done using data collection modules with large sample sizes. The market data is analyzed and forecasted using market statistical and coherent models. Also market share analysis and key trend analysis are the major success factors in the market report. To know more please Request an Analyst Call or can drop down your inquiry.

Primary Respondents

Demand Side: Doctors, Surgeons, Medical Consultants, Nurses, Hospital Buyers, Group Purchasing Organizations, Associations, Insurers, Medical Payers, Healthcare Authorities, Universities, Technological Writers, Scientists, Promoters and Investors among others.

Supply Side: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence, Regulatory Affairs Managers among others

Reasons to Purchase this Report

Customization of the Report

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Global Stem Cell Therapy Market Industry Demand, Scope and Strategic Outlook, Growth Analysis, Business Opportunities and Future Scope till 2025 -...

Inside the Beltway: Abortion, immigration among forbidden topics at Thanksgiving table – Washington Times

The warnings are already up in the popular press: Conversations during the Thanksgiving feast can be hazardous if they veer into political territory. But political talk can take place in theory: A data research company has now determined what topics are safe to talk about on the holiday.

With some qualitative analysis and a little common sense, weve created a cheat sheet that will help you blaze a path through Thanksgiving dinner that steers clear of treacherous political pitfalls and dangerous inter-uncle conflicts, reports Ranker.com, a Los Angeles-based media company which uses crowdsourcing to rank public opinion on multiple topics, typically at the rate of 15 million votes a month.

They have determined what political topics are the least and the most likely to set off a Thanksgiving dinner squabble. Their judgment is based on 300,000 votes from 40,000 respondents.

The topics to avoid this year: Abortion, immigration, terrorism and gender equality. The topics which are safe for dinnertime discussion: Ineffective government, health care reform and education.

If there are millennials present, they will be triggered, the organization says, by talk of abortion, police brutality and pollution. Generation X members will be set off by such topics as homelessness, affordable housing and campaign finance reform. Baby boomers will go to battle over terrorism, immigration and the moral decline of the nation.

The organization also has warnings for dinner hosts in certain states. If they live in Florida, their guests will be particularly sensitive about discussions of vaccines. In Indiana, its gender equality while Georgia diners are prone to fight over police brutality. Beware of talking about gun control at dinner tables in both California and Missouri; Texans get feisty over moral decline. New Yorkers get upset over transgender issues.

We examined each issue on a case-by-case basis to find the topics that are most likely to cause disagreement, as well as the ones on which people tend to either agree or not care about, Ranker.com explains.

A VERY SPECIALIZED MEAL

While most of us are enjoying turkey and pumpkin pie on Thanksgiving, the staff at one laboratory at Cedars-Sinai Medical Center in Los Angeles will be busy serving a meal to stem cells.

Stem cells do not observe national holidays, says Loren Ornelas-Menendez, manager of the very specialized lab that converts samples of adult skin and blood cells into stem cells which the human body uses to make our cells in the first place.

These special cells help medical scientists learn how diseases develop and how they might be cured. The lab is tending millions of them. Oh, but they have needs.

Stem cells are living creatures that must be hand-fed a special formula each day, monitored for defects and maintained at just the right temperature. And that means the cell lab is staffed every day, 52 weeks a year, the lab notes in a public advisory.

Many people have dogs. We have stem cells, says Ms. Ornelas-Menendez.

Derived from hundreds of healthy donors and patients, the resident induced pluripotent stem cells or iSPCs are keys to potential treatments for diabetes, breast cancer, Alzheimers disease, blindness, Parkinsons disease and Crohns disease, among other conditions. Ten lab technicians monitor the cells through microscopes each day and cull out any cells which have gone awry for one reason or another.

But what do they eat even on Thanksgiving?

While the cells get sorted, a special feeding formula is defrosting in a dozen bottles spread around a lab bench. The formula includes sodium, glucose, vitamins and proteins. Using pipettes, employees squeeze the liquid into food wells inside little compartments that contain the iPSCs. Afterward, they return the cells to their incubators, the lab advises.

Lab director Dhruv Sareen suggests that people consider offering a toast to the stem cells on Thanksgiving.

One day the cells they tend could lead to treatments for diseases that have plagued humankind for centuries, he says. And thats something to be truly thankful for.

THE GIPPERS FAVORITE

Back by popular demand, Inside the Beltway again shares this little known but historic recipe for President Reagans Favorite Macaroni and Cheese enjoyed by Ronald Reagan and his family on Thanksgiving and other holidays. What follows is a step-by-step shared by Mrs. Ronald Reagan, Washington, D.C., Wife of the President in a spiral-bound community cookbook published by the American Cancer Societys Northern Virginia division in 1983. The recipe serves six and is baked at 350 degrees F for 45 minutes.

The directions are from the cookbook reflecting the style, perhaps, of another era:

1/2 pound macaroni, 1 teaspoon butter, 1 egg, beaten; 1 teaspoon salt, 1 teaspoon dry mustard, 3 cups grated cheese, sharp; 1 cup milk.

Boil macaroni in water until tender and drain thoroughly. Stir in butter and egg. Mix mustard and salt with 1 tablespoon hot water and add to milk. Add cheese leaving enough to sprinkle on top. Pour into buttered casserole, add milk, sprinkle with cheese. Bake until custard is set and top is crusty.

Curious about what transpired at a Reagan Thanksgiving? A 1985 Los Angeles Times account noted this:

President and Mrs. Reagan gathered with their family for a quiet Thanksgiving dinner at their fogbound ranch in the Santa Ynez mountains, where the main topic of conversation was the weather. The Reagans did not seem to mind the enforced seclusion as they sat down to a traditional turkey dinner, prepared by Ann Allman, the Reagan familys longtime cook in California. It was an all-American menu that included cornbread dressing, cranberries, string beans, mashed potatoes, salad, pumpkin pie and monkey bread, a family favorite.

POLL DU JOUR

46% of Americans say long standing family tensions are the cause of family fights during holidays.

37% say general politics is the cause; 33% cite the 2020 presidential race.

24% say someones future plans cause the fights; 24% say money.

22% say the behavior of guests; 21% say drinking and alcohol.

18% say holiday cooking is the cause.

Source: A YouGov poll of 1,310 U.S. Adults conducted Sept. 25-26 and released Tuesday.

Have a happy Thanksgiving and thank you for reading Inside the Beltway.

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Inside the Beltway: Abortion, immigration among forbidden topics at Thanksgiving table - Washington Times

5 Scrubs and Exfoliators You NEED This Winter 2019 – Enstarz

Winter is not just for hot cocoa and cozy blankets; the season is not always kind to the skin.

When the air outside gets gold and dry, without proper care, you skin can quickly follow suit. Having dry skin is the most uncomfortable feeling in the world.

The entire winter season, dead skin cells can build up on the skin's surface, which would result in a dry and dull complexion. The cold weather can lead to chapped lips, cracked hands and dry flaky skin.

Once the temperatures drop, your skincare routine should rise to the challenge.

That's why it's important to moisturize at this time of the year. However, it's also important to keep exfoliation in your winter skincare routine, and here's why.

Exfoliation isn't something yo;ll need to put on the back burner. In fact, winter is one of the best times for exfoliations. If you aren't spending your snow days sloughing away dead skin, then you're totally missing out.

Exfoliations helps replenish the skin.

Between the dry indoor heating and the cold air outside, your skin cells need to hydrate. They easily die out faster in the colder season, so it's essential to buff away the dead cells so new cells can come in healthier. It's recommended to exfoliate at least twice a week.

Exfoliators improve the effectiveness of the moisturizers.

Because you'll be slapping extra heavy lotion for the winter, you'll want to maximize its power. Do this by exfoliating regularly. The dead cells block moisture from the layers of live skin cells that actually need it.

Exfoliating beads, salt or sugar scrubs, dry scrubbing or even common body sponges are best examples of physical exfoliants that will help tremendously.

The usual at-home scrubs are the sugar scrub and the salt scrub.

The difference between the two is that the sugar scrub is more gentle, less abrasive and tends to dissolve fast in warm water.

Whereas the salt scrub tends to be a little more aggressive because the granules are larger. With a salt scrub, you're going to want to exfoliate a little less than you would with a sugar scrub or other exfoliating beads.

Keep scrolling to check 5 of our top picks for adding some body scrub time to your tub or shower regime.

M3 Naturals Himalayan Salt Scrub

Detoxify the skin with the M3 Naturals Himalayan Salt Scrub. It is infused with collagen and stem cell that increases skin cell longevity. Combined, these deliver an anti-aging performance.

This salt scrub is made from an all-natural Himalayan pink salt with lychee fruit and almond oil that will provide moisture and cleans out impurities of the skin and will effectively remove dirt, oil and reduce the appearance of acne, scars, blackheads and cellulites.

(Photo : Amazon)

Dove Exfoliating Body Polish Body Scrub

This easy-to-find exfoliating body scub removes dull, dry skin while deeply nourishes it to restore its natural nutrients.

The product is formulated with moisturizing cream and has a whipped texture that provides a creamy coverage.

(Photo : Amazon)

Brooklyn Botany Arabica Coffee Scrub

A coffee body scrub that can be used on the face, hand and foot. It will easily remove dead skin giving you a fresher, younger and moisturized appearance.

It will also reduce the signs of aging because of the coffee's antoxidants, fighting the appearance of fine lines, sun spots and wrinkles.

(Photo : Amazon)

Majestic Pure Cosmeceuticals Sweet Orange Body Scrub

A vegan-friendly, bright and refreshing body scrub crafted with nourishing ingredeints such as sweet orange oil, dead sea salt, organic aloe vera juice and coconut oil.

Using this product can promote more supple and smooth skin, gently removing dead skin and exposing it to enriching and moisturizing minerals and nutrients.

(Photo : Amazon)

Shea Moisture Exfoliating Hand and Body Sugar Scrub

The sugar scrub is made from natural ingredeints that gently cleanses skin from impurities, pollutants and build-up. It is created with argan oil and organic raw shea butter.

It will provide your skin with intense moisture and can exfoliate your hand and body by removing dead skin cells.

(Photo : Amazon)

READ MORE: 7 Gifts that Will Not Break Your Bank Account this Christmas 2019

See Now: Famous Actors Who Turned Down Iconic Movie Roles

2019 ENSTARS, All rights reserved. Do not reproduce without permission.

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The 8 Most Iconic Beauty Products In The Black Friday Sales To Buy Now – elle.com

.

The Black Friday sales are almost among us, meaning the halls of your local department store are about to become a battleground. (The smartest of shoppers know the key to maintaining sanity is to do it all online.)

But when faced with deals and discounts from every angle, its crucial to keep your cool. You dont want to panic-buy all those as-seen-on-Instagram products before youre covered the essentials you know, the things you'll use day in, day out, until they're empty.

Resist those shiny, sparkling impulse buys (although yes, that glitter lipstick would look pretty good on NYE), and youll come out triumphant with a well-curated skincare edit that will keep your skin happy long after the last Quality Street has been polished off.

So, skip the scrolling and head straight for the good stuff this year. Here, discover the eight most unequivocally iconic beauty products we've spotted in the Black Friday sales. Trust us: you cannot go wrong with any (or all) of these heroes.

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1Soleil Tan De Chanel

Chanel

WAS 40 NOW 36

Soleil Tan de Chanel is the kind of product beauty dreams are made of. The weighty pot will last you all year, while the lacquered, double-C engraved pot will look incredibly bouji on your dressing table.

But of course,it's what's on the inside that really counts, and boy is this a brilliantly formulated bronzer. Unlike literally anything else on the market (many brands have tried and failed to 'dupe' it), this dense, mattecream can be picked up with a powder brush, dusted under or over foundation, and swiped strategically to carve out killer cheekbones it's revolutionary.

2Blanche Eau de Parfum

Byredo

WAS 110 NOW 93.50

Byredo's perfumes are coveted the world over, but with so many to choose from, you'll be hard-pressed to find a favourite without some kind of divine intervention.

Our advice? Head straight for Blanche, which is a byword for the crispest, cleanest scent you'll ever spritz. Forget cloying talc notes or blink-and-you'll-miss-it citrus: this is pure violet and musk-tinted freshness, like the cleanest cotton sheets that ever were.

And seeing as there's a very generous 15% discount (thank you, Liberty), maybe treat yourself to the body wash, too.

3The Rich Cream

205.00

WAS 205 NOW 174

The hype around Augustinus Bader's debut product was remarkable across the world, A-listers and beauty editors fawned. (Victoria Beckham even tapped him up to create her debut skincare product.)

Turns out, this clever cream really delivers. The secret is the Trigger Factor Complex, which works to kick-start the natural healing process of the body's stem cells. 30 years of research and development have clearly paid off.

4Bronzing Powder

Narsasos.com

WAS 31 NOW 24.50

The name of many a Nars product precedes its performance Orgasm, anyone? But not this one: the brand's Laguna and Casino bronzing powdersare famed for their supreme performance alone.

Both illuminate without relying on glitter (which always looks fake), and are warming without imparting those giveaway ruddy undertones.

Paler skins are destined for Laguna, while darker tones will love Casino. Your bank balance will love either.

5Diorshow Pump 'N' Volume HD Mascara

DIOR

WAS 28 NOW 25.20

Ask any beauty editor what their ride-or-die mascara is and you'll get...a lot of conflicting opinions.

Like the perfect shade of red lipstick, a favourite mascara is a subjective thing. After all,few can deliver perfection when it comes to length, volumeand colour. Enter Dior's Pump 'N' Volume: the mascara to unite us all. (And yes, it's the one with the no-wastesqueezy tube.)

6Do Son Eau De Parfum

Diptyque

WAS 120 NOW 96

Many of Diptyque's fragrances could be considered iconic, but Do Son is the one that'll see you being stopped by strangersin the street.

The tuberose trail is enticing enough, but it's the unusual addition of orange blossom and jasmine that take things to truly memorable heights. A spectacularode to its namesake beach, in Vietnam's Ha Long Bay.

7Ruby Woo Matte Lipstick

WAS 17.50 NOW 14

If you're a 'lipstick person', you already know about this one. You've likely got one stashed in your bag right now, as well as one on your dresser, and an 'emergency' onefloating around your bedroom somewhere.

So good it's never been successfully imitated, MAC's Ruby Woo is the ultimate lipstick. A true red, it's neither too orange or too blue, and there's no skin tone it won't look beautiful against.

8Glow Tonic

WAS 18 NOW 15.30

We all know that alpha-hydroxy-acids are the gold standard when it comes to resurfacing, but so many require a degree in dermatology to use correctly.

Forgo the faffing in favour of Pixis cult Glow Tonic: it might look cute, but its packed with 5% brightening glycolic acid alongside soothing aloe vera. Simply sweep it over cleansed skin nightly no brow-furrowing required.

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Hatching disease in a dish: The new frontier in drug testing – Maclean’s

Over lunch at the Canadian Centre for Alternatives to Animal Methods (CCAAM), Charu Chandrasekera nonchalantly mentions one of the projects her team is working on. We are just printing some human liver tissue right now, she says.

Chandrasekera launched the CCAAM at the University of Windsor in 2017, with help from the schools vice-president of research and innovation, Michael Siu, and dean of science, Chris Houser. The centre promotes non-animal methods in biomedical research, education, and regulatory (chemical safety) testing. In October 2019, the centre received a million-dollar gift from the Eric S. Margolis Family Foundation, which Chandrasekera says was instrumental in establishing the state-of-the art research laboratory, and in launching a number of important initiatives.

Chandrasekera says the move away from animal testing to human-based research models isnt radical but inevitable. After many years working in biomedical research with mouse models of heart disease and diabetes, It became very obvious that the work I was doing was not translatable [to humans], she says. Nothing was really reproducible; there were so many discrepancies and contradictions, even among the top-notch researchers.

Ninety-five per cent of drugs tested to be safe and effective in animal models fail in human clinical trials, says Chandrasekera. Alzheimers disease99.6 per cent drug failure rate, she says. It has been cured in mice. But we dont even understand the molecular mechanisms of this disease in humans, much less a cure.

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Empirical evidence from across a whole host of biomedical science disciplines shows us that animal models are failing both science and human health, echoes Elisabeth Ormandy, co-founder and executive director of Animals in Science Policy Institute, a registered Canadian charity working to promote better science without animals. Animal models can falsely show that a drug is effective, she says. They can also falsely show no effect, in which case a drug that would have been shown to be effective in humans never gets advanced to human clinical trials.

The result, she says, is billions of public tax dollars being wasted on research using ineffective animal models, and diversion of precious research funding away from other lines of scientific inquiry that might hold greater promise in terms of predicting drug safety, risk, and effectiveness.

Those other promising lines of scientific inquiry, say Ormandy and Chandrasekera, are human biology-based models. We can use human cells and tissues from cadavers, biopsies, and explanted organs [from surgeries], says Chandrasekera. And we can also engineer them. With adult stem cell technology, you can take a small biopsylike two-to-three millimetres from a persons skinto create any cell type in your body, she says. And if that person has a disease, such as Alzheimers, it will still be present in these cells. These cells can then be assembled to form tissue-like structures called organoids, or engineered through 3D-bioprinting to create more complex tissues, all of which can be combined to create what has become known as disease-in-a-dish. At present,Chandrasekera iscreating diabetes-in-a-dish.

Further, those cells and tissues can also be placed onto computer chips the size of thumb drives, where a large number of drugs can be tested to select whats most appropriate for youpersonalized medicine based on your cells, your tissues, your biologynot mouse biology, Chandrasekera explained in her April 2019 TedX Talk. The goal of the scientific community at large is to create a human-on-a-chip to emulate human biology better than animals, she says, which I think will happen over the next decade.

Currently there is no data on the success rates of human biology-based methods, because there are no drugs that have been approved without animal testing, since animal testing was mandated by regulatory guidelines several decades ago, says Chandrasekera.

However, a growing body of scientific data and internationally approved guidelines in chemical safety testing, indicate that alternative methods are equal or superior to animal models in predicting human biology, Chandrasekera says. Even computer simulations are out-predicting animal-derived data.

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Ifdisease-in-a-dish and toxicity-on-a-chip effortscontinue to advance at a fast pace with a sense of urgencybacked by global scientific, financial, legislative, and ethical mandates, she says, we will come to a point where we can test drugs without relying on animals.

And while Chandrasekera is busy both in the lab and on the global stage promoting her work, she is also focused on enlightening future scientists. Shes working on the development of courses and degrees to train the next generation, she says, to think outside the cage.

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Hatching disease in a dish: The new frontier in drug testing - Maclean's

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