Page 11234..1020..»

Archive for the ‘Skin Stem Cells’ Category

Make-up mistakes that make you look older – and item that should go in the bin – Mirror Online

Many of us rely on makeup as the secret to eternal youth. From covering up dark circles with concealer to adding a flush of colour with a rosy blush it's the perfect little pick-me-up.

But, of course, it's never that simple.

And if you're using the wrong products or the wrong techniques, you may not end up quite as fresh faced as you had hoped.

From using too much powder foundation to forgetting to use SPF, many of our go-to habits could actually be making us look older.

We speak to skin expert Paul Banwell to find out exactly what we should and shouldn't be doing.

To keep your skin hydrated, Paul says you can use simple methods to keep looking youthful.

He says: You can use a high intensity moisturiser, or use indigestible products like a liquid collagen drink - I recommend Skinade, the leading collagen drink which is carefully formulated, a mixture of vitamins and minerals which results in optimal skin health.

Wearing oil based products can clog pores and cause breakouts.

Paul says: The effects of clogged pores can be aided with medical facials like the photogenic facial from TBC Skin atelier, or microdermabrasion, followed by Dermalux LED treatments.

Alternatively, I'd recommend a hydroxyacid boost for pH equilibrium and chemical exfoliation - Rationale's Catalyst Range is best.

However, you can also make a difference by making small changes at home.

Paul says: Similarly, overusing fragranced and alcohol based products may dry out the skin, and in turn cause premature lines and wrinkles.

Try to use oil free products, and aim to use hydrating foundations and creams.

Pollution can be responsible for skin dryness, dullness, clogged pores and skin ageing.

Paul says: Some tips for shielding your skin from pollution are wearing sunscreen, using a good moisturiser to create a barrier between your skin and pollutants and double cleansing your skin - use a product like the Rationale Catalyst cleanser.

Sun exposure, both UV and infrared, can result in sunburn which also causes ageing issues for the skin as the years pass.

They're often credited with giving us a matte, flawless finish but powder foundations can be one of the worst culprits when it comes to ageing. Paul says: Avoid powders, as they tend to set into the fine lines of wrinkles which can make your skin look flaky.

For immune protection, and a product which can be used during a Sunday night ritual to make your skin look fresh and luminous for the week ahead which means you won't need to wear foundation, use the immunologist mask - to be performed weekly (the pot lasts 6 months).

It hydrates and reduces inflammation in problem/ sensitive skin.

While concealers are great for hiding flaws and imperfections, they can also draw attention to any unwanted lines and wrinkles.

Paul says: Concealers might be covering the dark circles, but they also accentuating fine lines, so make sure to only apply concealer to the inner half of your under eye.

Prepping the skin before wearing makeup is also key to a youthful glow. Paul says: Skin around the eyes is thinner that the rest of your face and shows age faster!

Eye creams and products that contain Retin A, a form of vitamin A, are most effective and promote the stimulation of collagen and elastin to tighten the skin.

Suncream shouldn't just be reserved for your annual holiday or trips to the beach. Rather, it should be part of your daily skincare regime.

Paul explains: UV exposure causes 90% of skin damage. Even people who already have signs of premature skin ageing can benefit from making lifestyle changes.

We should all be protecting our skin by using SPF 30 or higher which gives your skin a chance to repair some of the damage.

Fine lines and wrinkles absolutely have a part to play here too, and the best way to eradicate these is through protecting the skin against phototoxic damage and minimising loss of skin integrity.

Collagen peptides in a drink like Skinade will increase collagen turnover and are proven to minimise fine lines.

At the Banwell clinic, we offer Ultimate Sunscreen protection with Rationale B3-T, which will ensure skin is not affected as strongly when in sunlight.

After a long day, it can be tempting to just roll into bed without a second thought for your skin. But you may end up paying the price as a result.

Paul says: Sleeping in your makeup can result in the breakdown of healthy collagen which leads to premature skin ageing. Make sure to take your makeup off thoroughly, and Id recommend a Plasma Shower facial to boost cleansing of the skin, using stem cell technology.

Plasma showers alone help improve texture and quality of skin but can be boosted by various mesotherapy treatments including stem cells, hyaluronic acid and vitamins.

Essentially it encourages hydration, which is essential for optimum physiological functioning of the skin and to optimise all biological processes and immune protection.

Read the rest here:
Make-up mistakes that make you look older - and item that should go in the bin - Mirror Online

After 5 Years Of Trials, Doctors Create Human Liver From Scratch – CBS Pittsburgh

PITTSBURGH (KDKA) In a dish sits a human liver.

Not removed from a person, but created from scratch.

Its not like wahoo and the next morning you think, ah, Im gonna make a human liver,' says Dr. Alejandro Soto-Gutirrez of the Pittsburgh Liver Research Center.

It took five years of trial and error but using stem cells, genetic and tissue engineering, organ cultures and a team of experts in these areas, the researchers have come up with this.

Alexandra Collin de Lhortet, Ph.D. of the University of Pittsburgh School of Medicine explains the process.

A rat liver gets stripped of its cells so that only the connective tissue remains.

From a small piece of human skin, the scientists pluck out stem cells and coax them into becoming human liver cells and the cells are collected.

Then theyre injected into the chamber, called a bioreactor, where they take up residence in the empty rat liver.

The entire process from gathering the cells to make a liver, to get to this point, where you have an actual mini human liver in a bioreactor, takes several months.

It will stay alive, or viable, for only a few days.

But in that short time, the researchers can try different medicines to treat the diseased liver.

You could test any sort of therapeutic by simply injecting this chemical through the system, says Dr. Collin.

In the past, animal livers played a role in this kind of research but human livers didnt always respond in the same way.

With this system, the cells have had genetic modification to recreate diseases, for example, fatty liver, a growing problem in the United States.

This technology has the potential for personalized medicine. From your skin cells, they could grow your own mini liver to figure out which medicines would work for you.

I believe its a very good biological tool to screen treatments that are not otherwise being tested in humans themselves because its dangerous, says Dr. Soto.

As its designed, it would be a long stretch to create livers for transplantation.

If you mean how far we are to make actual livers for people, I think we are very far away. Were probably many years away. But this is a good step, Dr. Soto says.

More:
After 5 Years Of Trials, Doctors Create Human Liver From Scratch - CBS Pittsburgh

Do you have ‘diet face’? It’s everywhere | Times2 – The Times

Jenni Murray is spot on staying slim can take its toll on your features, says Christa DSouza

I do love Jenni Murray. For telling it like it is. For those of you not aware of the comments she made at the Henley literary festival, let me recap for you. She recalled the advice given to her by Barbara Cartland Jenni, you know, when you get older you sacrifice your face or your figure. Dont sacrifice your face, just sit down a lot. Murray went on to explain how, despite having gone through a gastrectomy to lose weight, she had, at the age of 69, decided to follow Babss advice because she didnt want to end up looking like Nigel Lawson. And thats no insult to Nigel Lawson, she went on to say in her mellifluous, unbitchy way, but you know, when he

Want to read more?

Subscribe now and get unlimited digital access on web and our smartphone and tablet apps, free for your first month.

Read more:
Do you have 'diet face'? It's everywhere | Times2 - The Times

Must-Try Spa Treatments During The Palm Beaches’ Spa And Wellness Month – Jupiter Magazine

PURE Cell Facial

Stem cells are controversial in medicine, but not in beautyat least not when it comes to the PURE Cell Facial available at the PURE Spa inside the Pelican Grand on Fort Lauderdale beach. The live roseroot stem cells used during this 80-minute service travel deep into the pores to regenerate skin and stimulate collagen. The spa is one of only two locations to offer the treatment, which uses products from Maria kerberg. Products are deepened into the skin using a mask that feels as thick as the molds orthodontists stick in your mouth to create retainers. The treatment makes the skin look tighter, and results can last four to six weeks. (2000 N. Ocean Blvd.,Fort Lauderdale; 954.556.7600) - Alyssa Morlacci

Forget everything you thought you knew about a relaxing massage and prepare yourself for ultimate bliss with the help of a quartz sand bed. Lucky for South Floridians, The Spa at Auberge Beach in Fort Lauderdale offers the award-winning, state-of-the-art Gharieni Quartz Treatment table (only one of two in South Florida) known to ionize the air, which supports the immune system and helps purify the body. During a massage, tight muscles are soothed with quartz sand poultices, targeting specific areas of concern. Guests interested in trying the bed can do so when booking the Resort and Balance Massage, the Quartz Sand Sound and CBD Wrap, or the Quartz Massage with Amethyst Oil. (2200 N. Ocean Blvd., Fort Lauderdale; 754.900.4067) - Melissa Puppo

This month, relax and rejuvenate with a wealth of treatments and packages starting at $99. Portions of proceeds benefit five local charities in support of Breast Cancer Awareness Month.

Four Seasons ResortPalm Beach

Take part in the 100-minute Pink Oceana Experience Package, which features a warm scalp treatment and massage and warmed application of a detoxifying ancient ocean clay wrap mixed with exfoliating Himalayan salt, all followed by a full-body Himalayan Salt Stone Massage. The treatment also includes your choice of sparkling ros or antioxidant-infused hibiscus tea and a Himalayan Salt Detox Bath Soak to take home. Enjoy pool, beach and fitness room access, in addition to a voucher for breakfast or lunch, and a 10-percent discount on all spa retail.(2800 S. Ocean Blvd., Palm Beach; 561.582.2800; $390)

Palm Beach Marriott Singer Island Beach Resort & Spa

For a facial thats ideal for all skin types, book the Si-Rose Facial Treatment. During the 50-minute treatment, rose extracts and rosehip oil help skin to restore vital hydration and balance. Its then followed by a warmed rose quartz massage to help increase circulation. (3800 N. Ocean Drive, Riviera Beach; 561.340.1755; $99)

The Sanctuary Salon & Spa

Get the best of both worlds with the Fire & Ice Sensation Package. This treatment includes a harmonized, rhythmic massage utilizing hot and cold remedies designed to reduce stress, relax and detoxify the body. Organic oil blends are then warmed for a custom therapeutic conditioning treatment before finishing up with a designer blowout. (101 N. Clematis St., Ste.115, West Palm Beach; 561.721.9648; $99)

Read this article:
Must-Try Spa Treatments During The Palm Beaches' Spa And Wellness Month - Jupiter Magazine

AIVITA Biomedical Announces Publication Concerning a Predictive Biomarker for Melanoma Patients Treated with the Company’s Platform Immunotherapy -…

IRVINE, Calif., Oct. 2, 2019 /PRNewswire/ --AIVITA Biomedical, Inc., a biotech company specializing in innovative stem cell applications, today announced the publication of an article titled "Preliminary observations on soluble programmed death-1 protein as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines" in the oncology journal Oncotarget. Robert O. Dillman, M.D., Chief Medical Officer at AIVITA, and other key members of the AIVITA team authored the article.

The publication suggests that because of its role as an immune checkpoint, levels of soluble programmed cell death protein-1 (sPD-1) could be useful as a prognostic biomarker or predictive biomarker in cancer patients treated with vaccines. The authors theorized that very low blood levels of sPD-1 may indicate lack of an existing anti-cancer immune response, while very high levels may indicate an active immune response that is suppressed. In between these extremes, a decrease in PD-1 following cancer vaccine injections may indicate an enhanced immune response that has not been suppressed.

Blood samples were obtained at baseline and four weeks later during a randomized trial in which patients with metastatic melanoma were treated with either AIVITA's immunotherapy, or an active control article. Median survival was more than twice as long in patients treated with AIVITA's immunotherapy. The combination of a very low baseline sPD-1, or absence of a very high PD-1, at baseline followed by a decline in sPD-1 at week-4 of the study was predictive of surviving 3 or more years in patients treated with AIVITA's immunotherapy, but not with the control article. Among patients treated with AIVITA's immunotherapy, these sPD-1 criteria appropriately classified 80% of 3-year survivors, and 86% of patients who did not survive three years.

"These observations suggest that sPD-1 may be a useful biomarker for melanoma patients being treated with our platform immunotherapy, and/or to predict efficacy after only three injections," said Dr. Robert O. Dillman, Chief Medical Officer at AIVITA. "We look forward to confirming these results in larger studies and investigating whether it can predict response in other cancers."

AIVITA is currently conducting three clinical studies investigating its platform immunotherapy in patients with ovarian cancer, glioblastoma and melanoma. AIVITA uses 100% of proceeds from the sale of its ROOT of SKIN skincare line to support the treatment of women with ovarian cancer.

CLINICAL TRIAL DETAIL

OVARIAN CANCER

AIVITA's ovarian Phase 2 double-blind study is active and enrolling approximately 99 patients who are being randomized in a 2:1 ratio to receive either the autologous cancer stem cell-targeting immunotherapy or autologous monocytes as a comparator.

Patients eligible for randomization and treatment will be those (1) who have undergone debulking surgery, (2) for whom a cell line has been established, (3) who have undergone leukapheresis from which sufficient monocytes were obtained, (4) have an ECOG performance grade of 0 or 1 (Karnofsky score of 70-100%), and (5) who have completed primary therapy. The trial is not open to patients with recurrent ovarian cancer.

For additional information about AIVITA's AVOVA-1 trial patients can visit: http://www.clinicaltrials.gov/ct2/show/NCT02033616

GLIOBLASTOMA

AIVITA's glioblastoma Phase 2 single-arm study is active and is enrolling approximately 55 patients to receive the cancer stem cell-targeting immunotherapy.

Patients eligible for treatment will be those (1) who have recovered from surgery such that they are about to begin concurrent chemotherapy and radiation therapy (CT/RT), (2) for whom an autologous tumor cell line has been established, (3) have a Karnofsky Performance Status of > 70 and (4) have undergone successful leukapheresis from which peripheral blood mononuclear cells (PBMC) were obtained that can be used to generate dendritic cells (DC). The trial is not open to patients with recurrent glioblastoma.

For additional information about AIVITA's AV-GBM-1 trial please visit: http://www.clinicaltrials.gov/ct2/show/NCT03400917

MELANOMA

AIVITA's melanoma Phase 1B open-label, single-arm study will establish the safety of administering anti-PD1 monoclonal antibodies in combination with AIVITA's cancer stem cell-targeting immunotherapy in patients with measurable metastatic melanoma. The study will also track efficacy of the treatment for the estimated 14 to 20 patients. This trial is not yet open for enrollment.

Patients eligible for treatment will be those (1) for whom a cell line has been established, (2) who have undergone leukapheresis from which sufficient monocytes were obtained, (3) have an ECOG performance grade of 0 or 1 (Karnofsky score of 70-100%), (4) who have either never received treatment for metastatic melanoma or were previously treated with enzymatic inhibitors of the BRAF/MEK pathway because of BRAF600E/K mutations and (5) are about to initiate anti-PD1 monotherapy.

For additional information about AIVITA's AV-MEL-1 trial please visit: http://www.clinicaltrials.gov/ct2/show/NCT03743298

About AIVITA Biomedical

AIVITA Biomedical is a privately held company engaged in the advancement of commercial and clinical-stage programs utilizing curative and regenerative medicines. Founded in 2016 by pioneers in the stem cell industry, AIVITA Biomedical utilizes its expertise in stem cell growth and directed, high-purity differentiation to enable safe, efficient and economical manufacturing systems which support its therapeutic pipeline and commercial line of skin care products.

View original content to download multimedia:http://www.prnewswire.com/news-releases/aivita-biomedical-announces-publication-concerning-a-predictive-biomarker-for-melanoma-patients-treated-with-the-companys-platform-immunotherapy-300929591.html

SOURCE AIVITA Biomedical, Inc.

See the article here:
AIVITA Biomedical Announces Publication Concerning a Predictive Biomarker for Melanoma Patients Treated with the Company's Platform Immunotherapy -...

9 Of The Best Dry Brushes For Head-To-Toe Exfoliation – mindbodygreen.com

One of the biggest barriers to entry for a regular dry brushing technique is finding a brush that's right for you. Of course you'll want something that's simultaneously exfoliating, encourages lymphatic drainage, and is comforting to the touchbut that likely means different things for different people. And, thus, people will respond differently to various brush strengths. Then there's the question of shape preference: do you like a handle or something handheld? Also, if you're vegan, you'll need to opt for a synthetic or natural plant-derived option, like sisal bristles, which are made from agave fibers. Then there's where you want to be doing the dry brushing, be it your whole body, just your face, or both.

While some of these answers are obvious (face versus body, vegan versus non), some take some guessing-and-testing: You likely won't know what type of handle you like until you try, nor will you know what bristle strength you're looking for. But a good rule of thumb is beginners should default to softer bristles, as they don't know how their skin will react, while more advanced can feel comfortable experimenting with stiffer options.

Here, we gathered the best on the market, with a wide variety of variables, so you can find one that will work for you.

Go here to see the original:
9 Of The Best Dry Brushes For Head-To-Toe Exfoliation - mindbodygreen.com

On creativity, plasticity and repentance – Arutz Sheva

The young Israeli patient I visited in the isolation room at the Dana Farber Cancer Institute in Boston in the late 1970s was very ill. Ravages of the disease and its harsh treatment were clearly evident.

Diagnosed with a uniformly terminal disease, he had traveled to this renowned center in the Longwood Medical Area to be treated with a newly developed regimen of aggressive therapy. This world-famous academic hub is the medical campus where Harvard Medical School and many of its affiliated hospitals are all located. Major breakthroughs in medicine were developed here, including the first curative treatment of leukemia, the first kidney transplant, the first use of an electrical current to restore heart rhythm. It was here that creative man leaped forward with innovative advances that saved lives.

At the time I was a post-doctoral research fellow at Harvard Medical School. Our family resided several houses from the Ravs daughters home where the Rav was living, and our Maimonides community was fortunate to be able to spend eight to ten hours with the Rav every weekend in prayer and in learning. The creative gesture so central to the Ravs philosophy of halakhic man is a prime characteristic of biomedical research, and my oscillation between the universe of cutting edge biomedical research and the world of Torah learning with the Rav, while worlds apart, was harmonious. With the Rav often expressing curiosity about aspects of my research, I began to intuit that the work might not be merely creative but in fact a religious gesture.

A central theme in the Ravs weltanschauung is his emphasis on halakhic mans creative gesture. Ish haHalakhahs mission and continuous challenge are to heal and repair a purposely flawed world, for in the creation process a modicum of chaos was formed prior to the worlds creation and deliberately injected into both organic and inorganic matter, including into man himself.[1]

Man himself symbolizes, on the one hand, the most perfect and complete type of existence, the image of God, and, on the other hand, the most terrible chaos and void to reign over creation.[2] In order to enable man to cope with his inexorable chaos and sin, the tool of repentance was also created prior to the worlds formation (Pesahim 54a).

In a reference to creative introspection in Eight Chapters, Maimonides states: The perfect man needs to inspect his moral habits, weigh his actions, and reflect upon the state of his soul every single day. Whenever he sees his soul inkling toward one of the extremes, he should rush to cure it and not let the evil state become established (chap. 4).

Max Scheler, an early proponent of positive creative repentance, points out that modern philosophy, on the other hand, sees in retrospection and repentance mostly a negative, superfluous, uneconomical act due to disharmony of the mind and ascribed to lack of thought, sickness or various illusions..[3]

Emulating Maimonides, the Rav emphasizes an essential continuous remodeling, a re-creation of the sinners self as being a healthy, critically indispensable creative process. Halakhic man is engaged in self-creation, in creating a new I. He does not regret an irretrievably lost past but a past still in existence, one that stretches into and interpenetrates with the present and the future.[4]

The Ravs perspective on repentance is related to Schelers definition of creative repentance and to Henri Bergsons distinction between subjective, qualitative time-perception versus chronos, quantitative objective time. Both Scheler and Bergson ascribe to the principle of memory and experiential plasticity. The concept of plasticity, the property of being easily molded and remolded, has received intense scientific attention in the last decade, especially as related to the field of memory and neuroscience.

The presumed inability of the brain to generate new cells or to establish new neural networks is currently vigorously challenged and has indeed been proven incorrect. The process by which man can modify imprinted memories to affect his present and future behavior pattern is currently under scientific investigation. Epigenetic biochemical modifications of DNA and changes in neural networks triggered by ongoing experiences have been documented to alter both content and intensity of memories. The association between past triggering stimuli and the resurfacing of memories and behavior patterns has been shown to be moldable utilizing imaging and histological techniques. Previous memories can be reinforced, intensified, modified, or completely erased.

We no longer look at our genetic makeup and the mature brain as a fixed template that predicts our phenotype, and no longer are our memories an unalterable code. Rather, increasingly, biochemical data support the idea that they are templates upon which environmental and emotional stimuli can impact. Biochemical changes in the brain triggered by environmental and behavioral patterns were identified in identical twins raised in different environments. Scientists have defined conditions in which terminally differentiated cells, such as mature skin cells, which we assumed could never return to their embryonic pluripotent stem-cell status, have in fact definitively reverted and reprogrammed to evolve into new cell types. Recent reports have described the astonishing generation of live mice from skin cells reengineered to be ova.

If cells can revert to their embryonic state, if gene expression can be reprogrammed, if the brain can generate new nerve cells and establish new neural networks, the view of repentant man as a biologically defined new self is viable.

David Anderson from the California Institute of Technology describes a fascinating neuro-anatomical observation. The center in the brain that orchestrates emotion is the amygdala. It communicates with the hypothalamus, which houses the cells that control instinctive behavior like parenting, feeding, mating, fear, and fighting. Anderson found that a nucleus of cells within the hypothalamus contain two distinct populations of neurons: one that regulates aggression and one that regulates mating. About 20 percent of the cells in this nucleus are active both during mating activity and during aggressive behavior, which suggests that these two circuits are linked. How does the brain regulate these mutually exclusive behavior patterns? Anderson found that depending on the specific stimuli applied to this area it can trigger either mating activity or aggression.

Perhaps creating a new self through repentance from love (On Repentance, pp. 163) is associated with using mechanisms previously utilized for aggression and fear for productive activity such as love and fertility. A similar idea is found in the Babylonian Talmud (Shabbat 156a): He who is born under Mars will be a shedder of blood. Rabbi Ashi said: Either a surgeon, a thief, a slaughterer, or a circumciser. Through biochemical processes induced by the intense experiences of the teshuvah process confession, sacrifice, remorse, shame and a commitment to a new I a new self can emerge.

* * *

A decade after I visited the seriously ill young man at the Dana Farber Cancer Institute, the facility where chaos reigns and where creative man is faced with overwhelming challenges, I attended a scientific conference in Tiberias, burial place of Maimonides. I learned that a daily minyan was available at a nearby archeological site of an ancient synagogue on the shores of the magnificent Sea of Galilee. I was welcomed by a group of yeshiva students from Bnei Brak who had been coming weekly to maintain a minyan at this historical site.

Following services I was approached by a bearded man, who inquired:Are you Dr. Goldberg?

Since I had never practiced medicine in Israel I was surprised to be addressed as a physician.

Do you remember me? he asked. I am that patient you visited at the Dana Farber so many years ago. I am healthy, married and have several children.

The Prophets and the Torah as well recognized a strong connection between sin and illness on the one hand and between repentance and healing on the other (On Repentance, p. 80).

Through the creative gesture both the body and the spirit can be remodeled and healed.

Notes:

1. See Rabbi Joseph B. Soloveitchik, Halakhic Man (Philadelphia, 1983), p. 102.

2. Halakhic Man, p. 109.

3. Max Scheler, On the Eternal in Man (New Brunswick, NJ, 2010), p. 36.

4. Halakhic Man, p. 113.

View original post here:
On creativity, plasticity and repentance - Arutz Sheva

haia Happy as I Am, Clean, Inclusive Skincare Brand Previews at ISPA 2019, Business World#224553 – New Kerala

LAS VEGAS: Can a skincare line actually have an impact on self-esteem, emotional wellbeing and even your sense of belonging? haia (Happy as I Am) - the new gender neutral, 360-degree wellness skincare line that industry leader, Michael Bruggeman, is debuting at ISPA 2019 - aims to do exactly that by going more than just skin deep.

A 2018 CDC study found suicide is at its highest rate in the U.S. in half a century. According to the World Health Organization, 300 million people have been diagnosed with depression. According to stopbullying.gov, 1 in 4 students have experienced bullying. Bruggeman decided to offer help from the outside in, via the industries he knows the best - skincare and wellness.

Ten years ago, he co-founded the first natural, professional spa brand for men, OM4 MEN, Organic Male, this year he founded the charitable foundation and leadership Institute, One Well World and four years ago, he became chair of the Global Wellness Institute's Beauty Meets Wellness Initiative.

Bruggeman couldn't help but notice a recurring theme when he conducted international roundtables with industry stakeholders in New York, London, Paris, Los Angeles and Hong Kong; when he spearheaded a Global Consumer Insights Study; and when he attended wellness summits around the world. People yearned to feel good about themselves - no matter their size, shape, race, gender or sexual proclivity - and be confident in who they were. And then there's the happy reality that natural, eco-conscious and clean products are the fastest growing segment in skincare and beauty. That kind of feedback inspired Bruggeman's decision to create haia.

Since beauty and belonging are such cultural drivers, our goal was to create a clean and inclusive skincare brand to help change the idea of living up to the social norm, explains Bruggeman, and remind you to love exactly who you are every day. And what better place to debut it than the spa & wellness industry's annual trade show & conference?

The recipe

Ingredients Using biomimicry from four different biomes - or large, naturally occurring habitats, such as a forest or tundra - he worked with some of the most sophisticated raw material manufacturers in the world to create products containing the latest in clean, nature-derived, active ingredients, such as extremophiles (microorganisms that live in conditions of extreme temperature, acidity, alkalinity, or chemical concentration), mesonutrients (the active compounds or antioxidants within superfoods found in longevity-inducing Blue Zone diets), plant stem cells and bioferments that promote a healthy skin microbiome.

Eco Certified/Cosmos Organic Beyond simply choosing organic ingredients, Bruggeman made a decision to work towards having haia qualify for Cosmos Organic, globally recognized as the highest level of organic and natural product certification that exists.

Collections The new line is divided into five different, color-coded collections with cleansers, toners, serums, moisturizers exfoliators, eye products and masks. The packaging uses a woven fabric design as a metaphor for weaving a single thread - standing for diversity and individuality -- into a fabric of strength and a work of art.

Affirmations, App & Animation - an April 2017 PSYCHOLOGY TODAY article by Dr. Leena Guptha said people can learn to incorporate self-affirmation into their arsenal of tools for coping with everyday threats and thus become agents in the maintenance of their own well-being. Each haia product has its own carefully selected affirmation such as I am Confident, I am Bold, and I am Worthy, I am Whole, I am Resourceful and I am Resilient.

Customers will be encouraged to access the industry's first ever animated skincare app on the haia website, which will have practical suggestions for implementing daily affirmations into everyday life. The app also features a virtual selfie derm-analysis that will give users personalized recommendations for product selection and use.

The animated characters not only reflect the skincare line's diverse target audience, but they can help take the pressure off spa and retail sales teams by providing a user-friendly and fun way for consumers to discover the regimen that is best for them.

Bruggeman adds, haia brings together the best of science and nature but beyond that, our hope is that the product design will make something as basic as your daily skincare routine inspire confidence, self-esteem and a sense of belonging.

Excerpt from:
haia Happy as I Am, Clean, Inclusive Skincare Brand Previews at ISPA 2019, Business World#224553 - New Kerala

Stemming the Tide of Alzheimer’s – UCI News

Keith Swayne has a magic touch when it comes to fundraising.

I guess I could go to anyone and get them to write some kind of check just so I would go away, he says, laughing. However, thats not what I want to accomplish. I want to connect people to causes and needs that they can relate to and then help them find a way to help out.

Swayne is so adroit at soliciting donations, in fact, that a campus project he undertook has left people shaking their heads in amazement: His efforts led to a $20 million windfall for investigators at the UCI Institute for Memory Impairments and Neurological Disorders.

Keiths passionate commitment to supporting our research has been tireless and nothing short of transformative, says Joshua Grill, director of UCI MIND.

It all started with a $150,000 gift the Laguna Beach philanthropist made to the research facility in honor of his late wife, Judy, whom he lost to Alzheimers disease in 2014. He also issued a challenge to the community at the time that boosted the donation to $300,000.

The UCI MIND team then leveraged that seed money to secure a total of $20 million in funding from the National Institutes of Health.

Our research is blazing new trails into understanding the genetic, molecular and cellular underpinnings of disease and is poised to lead to identification of new treatment targets and candidates, Grill says. Keiths initial challenge-gift enabled an exponential impact in terms of research support.

Weian Zhao lab at Sue and Bill Gross Stem Cell center at UCI. Lab personnel: Ling Shun, Meglu Han, Michael Toledano, Aude Segaliny, Jan Zimak, Leanne Hildebrand

His late wife would have liked that, Swayne says. The fact that some good came from this terrible disease Judy would certainly want that, he says. And I wanted that too.

The couple, married 50 years, were best friends and committed partners. Judy Swayne, like her husband, was intent on making a difference in her community. Among other contributions, in 1989, she founded the Orange County Community Foundation, which became a major philanthropic institution in the region. Keith Swayne has carried on her legacy as a member of its board, stepping down in September after a stint as chairman.

In addition, Judy Swayne served on numerous nonprofit boards, acted as a role model and mentor to many throughout the philanthropic community, and was the mother of two: a daughter, Anne Keir, who lives in Hawaii, and a son, Kirk Swayne, of Orange County.

The disease was hard on my kids, Keith Swayne says. Its a tough disease.

It was also hard on Swayne himself, Grill notes: Alzheimers is an insidious disorder that robs patients of their most human characteristics language, decision making and, of course, memory.

Ultimately, it also robs patients of their independence, putting a strain on family members.

Keith was a caregiver to his beloved Judy, a costly and taxing role, Grill says. He watched her progress until she succumbed to this unrelenting disease, helpless to do anything to slow or stop its course. He decided to do what he could to prevent others from suffering her fate.

Frank M. LaFerla, dean of the UCI School of Biological Sciences, also recalls Swaynes struggles.

Alzheimers disease really impacted his family, he says. Judy was a very special woman. He wanted to make sure future generations wouldnt experience the pain his wife did.

At the time, LaFerla was director of UCI MIND and talked with Swayne about ways he could make a difference in the search for a cure. One field of research involved stem cells, which experts believe may offer great promise for new medical treatments.

My lab had started getting involved with stem cells many years ago, and about this time a new technology was created using stem cells from your skin, not embryos, LaFerla says. You could take some of a patients skin cells by biopsy and reprogram them to become pluripotent meaning they have the ability to give rise to many different types of cells found in the body, such as brain cells or more skin cells or kidney cells.

Swayne likes innovation and taking chances, LaFerla says: I told him this opportunity was high-risk but had high potential.

That was when Swayne issued his challenge to the community and set about rounding up donors. He held salons at his hillside home, inviting LaFerla and other UCI staffers to speak to local residents. They explained how pluripotent stem cell technology could be used as a tool in Alzheimers research.

I went to people who knew my wife or to people I knew who also had a vested interest in Alzheimers research because they had the disease in their own families, Swayne says.

He found many community members who were willing to contribute.

The odds are that if you live to be 85, theres a 1-in-2 chance youre going to have Alzheimers. A lot of my friends are in my age bracket, says Swayne, 79. The message was compelling.

One thing he learned was that individuals were familiar with the Alzheimers Association but not UCI MIND.

In some respects, UCI MIND is one of the best-kept secrets in Orange County, Swayne says. Many people didnt know that its one of only 30 NIH-designated Alzheimers research centers in the country.

His fundraising zeal and efforts to involve the Orange County community in the effort eventually paid off. As LaFerla says, It worked better than we could ever have dreamed.

When the time came to renew funding for the stem cell research program from the National Institute on Aging, UCI MIND won a five-year commitment to continue its research. One reason behind the NIAs decision: local philanthropic contributions.

With charitable and federal funding in place, UCI established a bank of induced pluripotent stem cells, now a valuable resource for Alzheimers researchers globally. Today, hundreds of cell samples have been provided to investigators at UCI and 10 other research universities around the world, and UCI MIND scientists and their partners have received more than $20 million in grants.

And all of that stemmed, ultimately, from the initial gift we received from Keith, LaFerla says.

Adds Swayne: We grew $150,000 to $20 million. It blows me away.

Hes not resting on his laurels, though. Swayne continues to connect more donors to UCI MIND so that research can progress.

The UCI MIND team is devoted to this cause, he says. Its reassuring to know youve got people with this talent trying to find answers to this disease.

So Swayne writes letters to business and community leaders urging their backing, chairs a panel that seeks new opportunities for philanthropic gifts, speaks on behalf of the institute at public events, and co-leads a caregiver support group for men whose spouses have Alzheimers.

Keith gives a voice to the nearly 6 million Americans with Alzheimers and the more than 15 million caregivers like him, Grill wrote earlier this year in a letter nominating Swayne for the Outstanding Philanthropist Award, which will be conferred on Nov. 14 by the Association of Fundraising Professionals of Orange County in celebration of National Philanthropy Day. UCI MIND would not be the organization it is without the leadership of Keith Swayne.

The rest is here:
Stemming the Tide of Alzheimer's - UCI News

Save Your Skin 20+ Products That Block Pollution & Blue Light From Your Phone – Hollywood Life

While its common knowledge that UV rays are bad for your skin, you should also be wary of pollution & blue light & we rounded up products that protect you from these environmental aggressors.

Whether you live in a big city or not, pollution is found in the air everywhere and it is seeping into your skin, which is super scary. Aside from pollution, another factor affecting your complexion is blue light, which is radiated from your phones and computer screens. So, to protect your skin from all of these environmental aggressors, we rounded up the best products that defend your skin and help block daily exposure so that you can maintain a clear and smoothe complexion.

One of our favorite products is the Kitao Matcha + Chia Cleansing Cream, which is formulated with matcha green tea, acai, chia seed, and quinoa, which all work together to remove makeup and oil while stopping environmental pollution from aging your skin. The Ao Skincare 6000X Elemental Screen SPF 30, is another great product as its a sheer lotion formulated with New Zealand Astaxanthin, a super-antioxidant 6,000 times stronger than Vitamin C, to protect your skin from all different types of environmental stress, while repairing it from the damage thats already been done.

Other products intended to help fight pollution include the Paulas Choice Skincare Triple Algae Pollution Shield, which contains a triple-algae complex that prevents polluted particles found in the air from sticking to your skin and getting in your pores. The Murad City Skin Overnight Detox Moisturizer is also another one of our favorites because its formulated with antioxidants from marrubium plant stem cells, which help detoxify your skin while reducing the appearance of lines and wrinkles caused by pollution.

If youre looking to specifically target blue light exposure, look no further than the Chantecaille Blue Light Hyaluronic Serum. Its perfect for all skin types and is a gentle pre-serum formulated with botanicals that shield the skin from blue light pollution. Aside from creams, the DIFF Eyewear Kira Gold + Amber Tortoise blue light glasses are a serious must. Not only are these glasses super cute, but they also contain blue light lens technology that blocks 30% of HEV light. Plus, for every pair of glasses sold, DIFF will help to provide the gift of sight to someone in need.

We have to mention the Clarisonic Mia Smart Anti-Aging and Cleansing Skincare Device because this is the ultimate cleaning tool. It does just about everything for your skin including exfoliate, minimize pores, firm skin, reduce puffy under-eyes, and blend foundation. Using this after a long day will make you feel and look 10x cleaner.

No matter what youre looking for, click through the gallery to see a mix of great products that will protect your skin. Plus, if youre looking for a mix of fun products and lifestyle items, you have to try our newestHollywoodLife Box, which has a value of over $260 and is on sale NOW for only $49.99! Buy the box right now atHollywoodLifeBox.com& even better, use the code HLBOX25 to get a 25% discount off your entire order!

Here is the original post:
Save Your Skin 20+ Products That Block Pollution & Blue Light From Your Phone - Hollywood Life

"I have talked about this treatment for so long… I finally gave in and set up the GoFundMe page. It killed me to have to do it." – Echo…

AN ordinary man with ordinary interests, Patrick Keane loves life, even though it has become more of a challenge than ever before.

He cannot play a round of golf or go for a walk by the beach any more. But he doesnt want pity and exudes positivity. So he enjoys soaking in the sea air around Clonea or Garryvoe without stretching his legs.

But reality has a way of crashing through the faade at times, no matter how strong you are.

For Patrick, it can be when he wakes up and cannot feel his legs, or loses his train of thought, or misses his mouth when trying to eat because he cannot feel the spoon in his hand. Or if he gets out of bed and falls and screams at himself, Just get up will ya, ya fool!

But the man known as Pa to his friends, or Patch to his mother Margaret, brother Paul and sisters Yvonne and Elaine, dusts himself down, drags himself back to an upright position and goes about taking on the day in as fearless a fashion as possible, given what he must encounter now and the knowledge of what lies ahead.

Multiple sclerosis affects the central nervous system, the brain and the spine, and while the rate of degeneration differs for all, there is no escaping the degeneration. Ireland has 8,000 sufferers with apparently no cure.

Patrick, who was diagnosed in January, 2009, is not without hope however. A doctor, Denis Federenko, has been providing stem cell transplants to people from all over the world at the AA Maximov Hospital in Moscow, with some success, by wiping out the faulty immune system with drugs used to treat cancer and replacing it with stem cells taken from the patient.

Irish comedian, Stephen Garland is one who underwent treatment in November, 2016, having been told he was around six months away from being confined to a wheelchair.

He returned home just before Christmas that year and has thrived since, even writing a show about his journey to Russia and back.

Garland brought his creation, Post-Disposed, back to the world-renowned Edinburgh Fringe Festival in August, confirming his continuing improved health.

The treatment costs between 50,000 and 60,000 including aftercare and other expenses. It can be hard to ask for help but so many people have extended a hand to Patrick, without ever being asked. People Patrick doesnt know from Adam or Eve have even contributed to his cause and it moves him to tears.

Time is against the Corkman however, because if his condition exceeds 6.5 on a scale of 0-8, he will not be taken on. At present, he is between 5.5 and 6, and has been accepted, but clearly the treatment must take place sooner rather than later.

To that end, a Breakfast With The Stars event is taking place at The Park Hotel, Dungarvan on Thursday, October 10. Tipperarys All-Ireland-winning manager, Liam Sheedy and multiple champion jockey Davy Russell will regale patrons with stories from their careers, prompted by MC Marty Morrissey.

All proceeds will go towards funding Patricks treatment and ancillary expenses. Ticket purchasing details are below.

Here is more about Patricks story...

************

LAYLA walks into the family home in Ballinroad, just outside Dungarvan. It was Patrick who named her, after the Eric Clapton song that he happened to be listening to when the family were discussing what to call the now 12-year-old dog.

Music is a boon, a real infusion of energy, pumping the blood, making him feel like he could jump out of his skin and dance like the old days. He cant but that burst of adrenaline is a godsend.

I have the car adapted with hand controls, Patrick explains. I dont use my feet for driving. Push and pull the lever in the car.

On a Sunday morning I love nothing better, especially when I am down at home. Head down the coast road to Tramore, listen to a bit of music.

I would listen to absolutely anything. I am influenced by dads taste in music. All the older stuff, 70s, 80s rock music kind of stuff. You could find me listening to dance music two minutes later. Once it has a beat I couldnt care less.

Patricks dad, Richie Keane, was a hard worker, who was brilliant with his hands and especially with cars. And all his life he had a smaller shadow. The son looked up to the father like he was Superman.

When he was sick and on his last legs, talking through the window from the house he taught me how to take the sump off my car because it was cracked and leaking oil. He was able to guide me through it without looking at it, word for word.

I restored a Jeep that he left when he passed away. It was a 1983, same age as myself, Mercedes jeep. Very rare, like hens teeth. Restored it to about 25,000 to 30,000 worth.

I had to sell it. I couldnt drive it anymore because the leg was so bad. That was hard. That was the last connection. It was something I had to remember him by. The day I saw that go out the drive was tough.

Richie died in November, 2008, around the time of Patricks 25th birthday. Richies mother passed away two weeks later. Patrick was diagnosed with MS in January, 2009. Already a celiac and diabetic, he was accustomed to restrictions and putting up with things. This was a different stratosphere though.

It began with losing his balance and the development of numbness down his right side.

I went to the doctor, and I think, by the look on his face, he knew there was something not right. He sent me to Ardkeen (Hospital) and I got checked out. They had me in isolation for about a week. Then I was told it was MS.

I didnt know what it was but it was something I heard from a conversation when I was younger, That poor fella has MS. I didnt know I would end up the way I am now.

I have friends since that have been diagnosed after me that I have gotten to know from reaching out. There are a couple of them in a wheelchair. As it progresses, that is where you are heading. But there is a gentleman up the road and he must have it for 20-something years. Unless someone told you, you wouldnt know he has MS.

Part of the difficulty of dealing with MS is that no two cases are alike. Keeping active, having physiotherapy regularly and working are advantages and Patrick has not declined as quickly as others because of that.

But he has hit the secondary stage, where there are cognitive problems and, in particular, his short-term memory is affected.

People say to me, do you get pain with it? I dont know what new pain or old pain is. I just get on with. I have my days where I whinge and moan and cry. God knows I have them. But there is people out there worse off. I have what I have.

It could get worse. Now that it is gone to progressive MS, it probably will. When or how long? Who knows?

It is a horrible disease, there is no two ways. But you get up, get on with it, and do what you can.

He went to Australia not long after the diagnosis. It was a real gesture of defiance, one that probably scared his mother but he knew too that it might well be a case of now or never.

A blocklayer by trade, Patrick eventually had to give that up as his coordination worsened and he nearly fell off a roof. He is on crutches now for three years and would not be able to catch a football if you threw it at him. He wears a leg cast too, to reduce the instances of tripping himself up, without eradicating them totally. He has a mobility scooter.

A 35-year-old man doesnt dream about a mobility scooter, he wants a flash sports car. But it allowed me to go down to the Greenway for the first time. That was nice, to be on the Greenway, to be out, and see the whole lot of it, it was lovely. But watching other people cycle off down killed me.

My two nephews were out the front playing soccer. I used to do the exact same thing. They were saying Patrick, are you coming out to play? I said I would love to but that gets you. Its the simple little things.

Katie, my partner, I dont know where I would be without her. My mam, the girls and my brother, they are fantastic. They have been with me since the start of it.

I decided I want to be independent. If I didnt have the car I dont know what I would be doing. That is my freedom. I can get into the car, go to the shop for coffee. I will get there. I will get the same place as anyone else will, but it will take me longer.

He lives in Cork with Katie and her son Aaron, and works for Voxpro, who have been tremendously supportive. If he were housebound, he would wither.

I am an outgoing guy. I would chat away, waffle on about anything for hours on end. But you take that away I dont know have I changed since the diagnosis.

I have tried to remain as positive as possible but sometimes its hard. Simple little things you take for granted. Just run out there to get the clothes off the line. Now I have had to get handrails put into the house so that I can get up when I trip and fall.

I would wake in the mornings and the legs are like jelly. They shake, you cant control it, you let them shake out and that could be for 20 or 30 seconds. Real spasticity and stiffness in the legs. With the heat during the summer, I sat in the car with the air con on. I would be good for doing weather forecasta. I know what its like when I wake up in the morning, ever before the curtains are pulled. I feel it in my body.

He has been trawling for potential treatments, along with his medical team. Dr Federenkos work stands up to inspection. Stopping the MS in its tracks without the need for further medication would be a tantalising prospect.

Reversing the effects is something he dare not even contemplate, though the treatment has had that effect in Garland and many others.

Being given the green light, after Dr Federenko reviewed his case and medical records, was like an infusion in itself. Patrick details every step of the treatment and though it sounds daunting, it isnt compared to the alternative.

He set up the GoFundMe page (https://www.gofundme.com/f/stop-ms-progression-with-stem-cells-transplant) and was staggered by the reaction. Meanwhile, the local community has rallied, as have his work colleagues and friends, organising fund-raiser after fund-raiser. People he didnt know had events. He finds it hard to process.

To ask for someones help, it is a sign that you are not able. I have talked about this treatment for so long and I got so bad in my legs and balance and everything, I finally gave in and set up the GoFundMe page. It killed me to have to do it.

There was a donation yesterday on GoFundMe from Jamaica. I dont know the person but they found it in their heart to say, There you go. People said to me, Sorry I cant give you too much, I want to give you more. If it is a euro or 20 cent, it could be that 20 cent or euro that gets me over the line.

Whatever happens, he will not give up because it is what he learned when he was Richies shadow: It is instilled in me from dad, I would always have looked up to him. Even now, since he has passed away, I would always say to myself, What would he do? Would he have approved of that? He would always say to stick at something until you get it. If you are going to start something, do it. Just dont walk away from it.

Breakfast With The Stars, featuring Tipperary manager Liam Sheedy, one of the all-time greats of National Hunt racing Davy Russell and RTs Marty Morrissey, takes place at The Park Hotel on Thursday, October 10. To book a table of 10 for 1000 contact Michael Ryan (087 2585299) or The Local Bar (058 41854).

Donations can also be made to Patrick Keanes GoFundMe pagehttps://www.gofundme.com/f/stop-ms-progression-with-stem-cells-transplant

Follow this link:
"I have talked about this treatment for so long... I finally gave in and set up the GoFundMe page. It killed me to have to do it." - Echo...

The Absolute Best Neck Cream on the Web (and 12 More We Also Love) – Yahoo Lifestyle

Weve been slathering moisturizer on our face for years, we exfoliate regularly and we even jumped in headfirst to trendy ten-step skin-care routines (sometimes even morning and night). But we recently realized something big: That we were stopping the skin-care love at our jaw. Think about it: Our neck and dcollet are prone to just as much sun damage, pollution and general aging concerns as our face, because all of these areas are typically left exposed (unless its mid-winter and were on the turtleneck train).

While its certainly possible to use face products on the neck, the skin on this part of the body is thinner and the concerns are a bit different. Thats where a specialized neck cream comes in. Specifically formulated to lift sagging skin and make horizontal lines disappear, these creams are the trick to achieving the youthful look we want. Here are 13 formulas that reign supreme.

RELATED: The Best Eye Cream for Wrinkles, from $13 to $315

Introducing: the end all be all of neck creams. This product not only gets rave reviews from shoppers for how well it works, but it has also won countless awards in the beauty spacefrom New Beauty to Shapemagazine to Harpers Bazaar. Why? Four main line-fighting ingredients: Niacinamide (to strengthen the skins barrier and supercharge the other ingredients), peptides (to plump skin and address fine lines and wrinkles), ceramides (which can help replenish and restore skin and improve its texture) and hyaluronic acid (aka the most powerful hydrating ingredient there is, which holds 1,000 times its weight in water). After just a few uses of this cream youll notice a visibly tighter, lifted and smoother appearance. Take that, tech neck.

Buy It ($139)

While it is a major concern, neck issues dont just stem from staring down at our phone all day long. Environmental aggressors from sun and pollution can also accelerate aging of the skin. This firming cream helps to reverse the damage on the neck and dcollet with amino acids that stimulate collagen production. How well does it work? One reviewer says, "I am on my second bottle, because the first worked so well. It is worth the price."

Buy It ($88)

If you have a nut allergy, finding natural beauty products can be a bit tricky since everything seems to be made from some form of coconut. But were happy to report that this organic neck cream is totally nut-free. Instead, youll find ingredients like hibiscus to increase elasticity, edelweiss to tighten the appearance of skin and botanical hyaluronic acid to deeply hydrate. It's "easily spreadable and light" as one reviewer stated, but it's powerful enough to really get the job done.

Buy It ($92)

We slather on collagen products to up elasticity on our face, but why dont we do the same to the rest of our skin? We no longer have an excuse with this collagen-packed tightening cream made to tauten and tone the thicker parts on our neck that are prone to premature sagging. And if you're wondering if the results are visible,ponder no more. A loyal user says, "I noticed a change after just using one jarI don't think that has ever happened."

Buy It ($135)

The product name says it all. This cream quite literally perfects the skin on the neck and dcollet by lifting and firming while fading dark spots and hyperpigmentation from one too many days in the sun. Its paraben-free and dermatologist approved, and one reviewer dubbed it her "daily need" so you know it lives up to the hype.

Buy It ($78)

While we can treat damage that has already been done, we love this neck cream for its ability to also protect against future damage. Retinol works the same as it does on our face to resurface skin, revealing newer, younger cells over time. But most impressively, after a 28-day consumer study, 100 percent of participants reported fewer fine lines and wrinkles, improvement of skin texture and firmer, younger looking skin. One person even had people ask whatshe was doing differently.

Buy It ($75)

Guys, Gwyneth Paltrow is this brands creative director of makeup, so you know its products pass the clean test. This product in particular is formulated with a blend of fruit stem cells and botanical extracts to fade fine lines and wrinkles by improving skins elasticity. Plus, the addition of peptides helps to reduce the depth of crease lines from staring at our phones all day. Oh, and 93% of users on Dermstore give it a five-star review.

Buy It ($60)

You dont need to get a pricey cosmetic procedure to restore your neck to its youthful best. Just slather on this cream for restored firmness and softer skin (one reviewer couldn't stop raving about how smooth it made her skin). Its advanced delivery system uses something called nano-platinum particles to target cell structures and lift sagging skinall without going under the knife.

Buy It ($67)

We cant get enough of BareMinerals all-natural makeup, and this neck cream has us stockpiling its skin care too. Its formulated with the same vegan, cruelty-free standards (aka no animal testing or byproducts ever) and provides results that you can actually see in as little as four weeks. How, you ask? Mineral gold with age-defying peptides, which helps to visibly reduce the appearance of wrinkles and horizontal neck lines by upping skins natural collagen production. Skin is left looking more firm and dewy but not greasy.

Buy It ($45)

It Cosmetics dubs this cream shapewear for your neck, and based on that statement alone, were sold. This product has been clinically tested to reduce the look of those deep-set horizontal neck lines we thought we had to live with until now. Just slather it on morning and night and the fast-absorbing formula will get to work improving firmness, smoothness and elasticity thanks to a tightening effect. Have sensitive skin? Youre free to use this gentle cream and reap all the benefits without irritation. Plus, as one reviewer states, you just might notice a difference in as little as one week.

Buy It ($52)

Sometimes all it takes to start a morning off on the right foot is a French skin cream so luxurious that we feel like were in Paris (just let us have this). Thats where Sisleys neck cream comes into play. Made specifically to treat the delicate skin below our jaw, it creates an immediate tightening effect by adhering an invisible elastic film onto the surface of the skin for a physical and noticeable lift.It'sinfused with soy fiber extract to fight the loss of firmness and improve skin tone, as well as a decadent amount of shea butter, which leaves skin super hydrated, nourished and softer than ever before. Now all we need is a warm buttered croissant waiting for us in the kitchen and our Parisian fantasy is complete.

Buy It ($180)

Tarte already makes our favorite concealer, so it's no surprise that we love its highly-rated neck cream, too. This naturalmulti-tasking treatment hydrates delicate skin with three ingredients: maracuja (aka passion fruit), sodium hyaluronate and algae extracts.The trio helps to target and improve the appearance of theneck and dcolletby promoting cell regeneration and skin elasticity. The results? Fewer fine lines and wrinkles and a lifted, less-crepey appearance.

Buy It ($44)

Fact: The neck and dcollet are some of the first stops to reveal our age. Thanks to thinner, more sensitive skin and the exposure to environmental aggressors, we start to noticesagging and creasing in these places before the same problems reveal themselves on our face. Not to worry though, because this rich cream is specifically formulated for those very concerns. It goes on smooth and absorbs quickly, leaving behind a hydrated and plumperappearance, effectively fading fine lines and wrinkles. But this cream does so much more than moisturizeit's packed with retinol and tripeptides to encourage cell turnover and collagen production, which help to reveal newer, more youthful skin beneath it. Plus, bearberry leaf extract acts as an eraser for dark spots by brightening and evening out pigmentation issues. Oh, and one reviewer mentions that i smells like vanilla. Um, why haven't we been using this our whole adult life?

Buy It ($104)

RELATED:8 Dark Spot Treatments That Help Battle Sun Damage

PureWow may receive a portion of sales from products purchased from this article, which was created independently from PureWow's editorial and sales departments.

Read this article:
The Absolute Best Neck Cream on the Web (and 12 More We Also Love) - Yahoo Lifestyle

An expert reveals the top 5 leading causes of hair loss – woman&home

Hair loss at any age can be distressing, and getting to the root of the cause can be easier said than done as there are a myriad of reasons why your tresses may not be as full as they once were.

In fact, recent research commissioned by leading hair supplement provider Viviscal revealed that there was confusion amongst those surveyed as to the real reason for behind their hair loss.

50 per cent of women over 25 revealed that hormones including pregnancy, menopause andpolycystic ovary syndrome (PCOS) had contributed to their hair loss or thinning, while 27 per cent of women felt that diet was a key factor in their loss or thinning.

In response Dr Martin Wade, Consultant Dermatologist at The London Skin and Hair Clinic, has given his expert opinion on the top 5 leading causes of hair loss (in no particular order).

1. Seasonal shedding: As days get shorter its thought that the pineal gland which secretes melatonin and according to this research paper has long been known to modulate hair growth in the brain gets less light stimulation. This has a consequence as the process by which the pineal grand secretes melatonin is dictated by light.

2. Ageing: Androgenetic Alopecia is one of the most common forms of hair loss for both men and women, and is also referred to as female or male pattern hair loss. Each time the hair follicle goes through the hair cycle it reduces in size, resulting in a smaller hair shaft. Over time the hair shaft becomes so small that it no longer protrudes above the level of the skin in the scalp.

MORE:This hair loss shampoo and conditioner with over 400 5* reviews has just launched in Boots

3. MW: Post pregnancy: After a woman gives birth there is a massive dip in female hormones, and a much milder effect can occur when women stop taking the oral contraceptive pill. This sharp change in oestrogen and progesterone levels both of which play a vital role in promoting hair growth can lead to hair loss.

4. Menopause: As with the above when a woman goes through the menopause she will go through a gradual yet progressive decline in female hormones.

5. Diet: This is complex area but, essentially, if the body is not getting the key nutrients it needs for healthy hair growth including vitamin A, B and C and minerals such as calcium and magnesium, according to this study or if the body goes into shutdown mode from a lack of calories due to a restrictive diet or dramatic weight loss over a short period of time, this could upset the bodys internal metabolism. A recent UCLA study showed that hair follicle stem cells have their own unique metabolism.

Have you experienced any of the above?

Read more:
An expert reveals the top 5 leading causes of hair loss - woman&home

Amniotic Fluid Stem Cell Therapy Market Growth to Be Fuelled by Advancements in Technology – Zebvo

Stem cells are biological cells which have the ability to distinguish into specialized cells, which are capable of cell division through mitosis. Amniotic fluid stem cells are a collective mixture of stem cells obtained from amniotic tissues and fluid. Amniotic fluid is clear, slightly yellowish liquid which surrounds the fetus during pregnancy and is discarded as medical waste during caesarean section deliveries. Amniotic fluid is a source of valuable biological material which includes stem cells which can be potentially used in cell therapy and regenerative therapies. Amniotic fluid stem cells can be developed into a different type of tissues such as cartilage, skin, cardiac nerves, bone, and muscles. Amniotic fluid stem cells are able to find the damaged joint caused by rheumatoid arthritis and differentiate tissues which are damaged. Medical conditions where no drug is able to lessen the symptoms and begin the healing process are the major target for amniotic fluid stem cell therapy. Amniotic fluid stem cells therapy is a solution to those patients who do not want to undergo surgery. Amniotic fluid has a high concentration of stem cells, cytokines, proteins and other important components. Amniotic fluid stem cell therapy is safe and effective treatment which contain growth factor helps to stimulate tissue growth, naturally reduce inflammation. Amniotic fluid also contains hyaluronic acid which acts as a lubricant and promotes cartilage growth.

With increasing technological advancement in the healthcare, amniotic fluid stem cell therapy has more advantage over the other therapy. Amniotic fluid stem cell therapy eliminates the chances of surgery and organs are regenerated, without causing any damage. These are some of the factors driving the growth of amniotic fluid stem cell therapy market over the forecast period. Increasing prevalence of chronic diseases which can be treated with the amniotic fluid stem cell therapy propel the market growth for amniotic fluid stem cell therapy, globally. Increasing funding by the government in research and development of stem cell therapy may drive the amniotic fluid stem cell therapy market growth. But, high procedure cost, difficulties in collecting the amniotic fluid and lack of reimbursement policies hinder the growth of amniotic fluid stem cell therapy market.

The global amniotic fluid stem cell therapy market is segmented on basis of treatment, application, end user and geography:

Rapid technological advancement in healthcare, and favorable results of the amniotic fluid stem cells therapy will increase the market for amniotic fluid stem cell therapy over the forecast period. Increasing public-private investment for stem cells in managing disease and improving healthcare infrastructure are expected to propel the growth of the amniotic fluid stem cell therapy market.

However, on the basis of geography, global Amniotic Fluid Stem Cell Therapy Market is segmented into six key regionsviz. North America, Latin America, Europe, Asia Pacific Excluding China, China and Middle East & Africa. North America captured the largest shares in global Amniotic Fluid Stem Cell Therapy Market and is projected to continue over the forecast period owing to technological advancement in the healthcare and growing awareness among the population towards the new research and development in the stem cell therapy. Europe is expected to account for the second largest revenue share in the amniotic fluid stem cell therapy market. The Asia Pacific is anticipated to have rapid growth in near future owing to increasing healthcare set up and improving healthcare expenditure. Latin America and the Middle East and Africa account for slow growth in the market of amniotic fluid stem cell therapy due to lack of medical facilities and technical knowledge.

Some of the key players operating in global amniotic fluid stem cell therapy market are Stem Shot, Provia Laboratories LLC, Thermo Fisher Scientific Inc. Mesoblast Ltd., Roslin Cells, Regeneus Ltd. etc. among others.

The report covers exhaustive analysis on:

Regional analysis includes

Report Highlights:

NOTE All statements of fact, opinion, or analysis expressed in reports are those of the respective analysts. They do not necessarily reflect formal positions or views of Persistence Market Research.

Continue reading here:
Amniotic Fluid Stem Cell Therapy Market Growth to Be Fuelled by Advancements in Technology - Zebvo

Michael Schumacher health latest: What is stem cell therapy and how will it help Schumi? – Express.co.uk

Formula One legend Michael Schumacher suffered life-changing head injuries in a skiing accident in 2013 and has since been receiving care at his home in Switzerland. It is believed the record-breaking racing driver cannot walk or stand and may have trouble communicating according to former Ferrari manager Jean Todt. So far Mr Schumachers treatment has been kept private, and nothing has been confirmed officially, however now the racing legend is under the care of world-renowned cardiac surgeon Philippe Menasch.

Mr Menasch is described as a pioneer in cell surgery at his hospital, Georges-Pompidou, in Paris.

According to the NHS: Stem cells are special cells produced by bone marrow (a spongy tissue found in the centre of some bones) that can turn into different types of blood cells.

The cells have been used since the 1980s to grow skin grafts for patients who have suffered life-threatening burns.

Read More:Michael Schumacher health update: Where is Michael Schumacher now?

They are also used in cancer treatments for cancers of the blood, and most recently have been used in repairing damage to the cornea - surface of the eye.

A lot about stem cells is still being discovered, with clinical trials taking place for illnesses and conditions like MS and macular degeneration, heart disease and spinal cord injuries.

The special cells are also being used in neurodegenerative diseases like Parkinsons and Alzheimers and traumatic brain injuries like Mr Schumachers.

In an interview online, Mr Menasch explained stem cell treatment for cardiac conditions is only touching the surface.

Read More:Michael Schumacher could be able to cry and move his thumbs'

He said: Nobody really knows how stem cells are working.

They do not permanently transplant into the myocardium, the muscular tissue of the heart after a couple of days or weeks they just disappear.

Mr Schumacher received stem cell therapy in September in Paris, however, not much information has surfaced about the procedure.

MrMenasch spoke to Italian newspaper La Repubblica and said: There was an explosion in the attention our department received but the situation has already normalised.

Local media dubbed the procedure experimental however MrMenasch denied this saying: everyone is looking for me but I have not used experimental cures.

I do not perform miracles. My team and I are not doing an experiment, an abominable term that is not in line with a serious medical view.

Michael Schumacher is motor racings most successful driver, with a record 91 Grand Prix wins.

He won his first titles with Benetton in 1994 and 1995 followed by five in a row with Ferrari between 2000-2004.

More here:
Michael Schumacher health latest: What is stem cell therapy and how will it help Schumi? - Express.co.uk

Global Stem Cell Therapy Market Report, 2019-2030 : Focus on Treatment Type, Cell Source, Indication and Competitive Landscape – Space Market Research

The global stem cell therapy market growth has been primarily attributed to the major drivers in this market such as the increasing prevalence of chronic diseases, rising number of clinical trials for cell-based therapy, steady investment, and consolidation in the regenerative medicine market, and favorable regulatory environment.

Get free pdf sample : https://www.marketindustryreports.com/pdf/32

Key Players in the Stem Cell Therapy Market are:

Market Definition: Stem Cell Therapy Market

Stem cells are human cells that have the ability to develop into various cell types such as muscle cells, brain cells they also have the unique ability to repair damaged tissue. Stem cells are divided into two major categories namely: embryonic stem cells and adult stem cells. The embryonic stem cell that is being used to conduct research today came from unused embryos resulting from an in vitro fertilization process which were later donated to science. These embryonic stem cells are pluripotent this basically means that they can turn into more than one type of cell. There are two types of adult stem cells- one of the type comes from fully developed tissues, such as the brain, the skin, and even bone marrow. The second type is induced pluripotent stem cells. These are adult stem cells that have been manipulated in a laboratory to take on characteristic of embryonic stem cells which enables them to turn into more than one type of cell.

The worldwide Stem Cell Therapy Market report give point by point data about the Stem Cell Therapy Market with a fitting examination of a few parameters and patterns impacting its advancement at a worldwide premise.

Scope of the Market :

The stem cell therapy market research provides a holistic view of the stem cell therapy market in terms of various factors influencing it, including regulatory reforms, and technological advancements.

The scope of this report is centered upon conducting a detailed study of the products allied with the therapeutic application of stem cells. In addition, the study also includes exhaustive information on the unmet needs, perception on the new products, competitive landscape, market share of leading manufacturers, the growth potential of each underlying sub-segment, and company, as well as other vital information with respect to global stem cell therapy market.

Market Segmentation

Market drivers: Stem Cell Therapy Market

Market Restraints: Stem Cell Therapy Market

Key Developments: CRISPR Technology Market

Stem cell therapy is accelerating at a huge growth circle that promises a potential for diversified career opportunities.

Get exclusive discount on report : https://www.marketindustryreports.com/discount/32

Table of Contents

INTRODUCTION

RESEARCH METHODOLOGY

In light of the examination of affecting development and constraining parameters, the exact information showing the future development pattern of the market can be gotten, which is altogether clarified in the Stem Cell Therapy Market research report. The data with respect to the moving toward circumstances that can help the market capitalization is additionally incorporated into the report. The report likewise involves fundamental data, for example, yearly income age, advertise esteem, use, yearly deals, and other significant measurable information, with respect to the key market contenders which incorporate a few associations, firms, item makers, sellers, and wholesalers.

Get exclusive discount on report : https://www.marketindustryreports.com/discount/32

Read More About Report Click Here:

About Us

Market Industry Reports is a global leader in market measurement and advisory services. It is 100% subsidiary of Maniks Systems Pvt Ltd. The firm has always been at the forefront of innovation to address the worldwide industry trends and opportunities.

Contact Us-

2nd Floor, Manikchand Ikon,

B-Wing, Dhole Patil Road,

Sangamwadi, Pune 411 001

Email: [emailprotected]Phone: +1 347 767 5477 ( US )+ 91 8956 767 535 ( IN )Website: https://www.marketindustryreports.com/Follow Us- LinkedIn | Twitter | Facebook

See the rest here:
Global Stem Cell Therapy Market Report, 2019-2030 : Focus on Treatment Type, Cell Source, Indication and Competitive Landscape - Space Market Research

Health Repair Damaged or Diseased Tissue with Stem Cell Injections 10:38 AM, Sep 28, 2019 – WXYZ

Dr. Mansour identifies two defining properties of stem cells: First, they can self-regenerate, meaning they divide and give rise to more regenerative cells of the same kind. Second, stem cells can mature or differentiate into specialized cells which carry out a specific function in the skin, muscle, or blood.

A major breakthrough in modern medicine revolves around the use of Umbilical Cord Stem cells. These powerful cells are injected into damaged tissues, ligaments, muscles and tendons, arthritic joints, or other tissues in an attempt to stimulate and accelerate healing.

Regenerative Medicine from Umbilical Cord Stem Cells in Macomb County

We were the first clinic in Michigan to offer umbilical cord stem cell injections as a holistic alternative to pain management and cell regeneration.

Dr. Mansour conducts monthly educational seminars and offers free one on one consultation, during which he reviews all imaging studies to determine if the patient is a candidate for stem cell therapy. For those who qualify, he offers a customized plan that is specific to each patient.

There is a wide range of conditions which may be treated with stem cells, including:

Joint Pain

Arthritis

Ligament Tears

Cartilage Tears

Meniscus Tears

Nerve Damage

Back Pain

And So Much More!

A Better Approach with Revolution Wellness

Are you suffering from constant discomfort, or diagnosed with a specific condition only to be told that medication or surgery are your only options? At Revolution Wellness, we believe otherwise. We use the innovative technology of stem cell therapy to treat discomfort and serious physical ailments.

Call our office today for more information about how we can get you on your way to living with less pain!

Read more:
Health Repair Damaged or Diseased Tissue with Stem Cell Injections 10:38 AM, Sep 28, 2019 - WXYZ

Meet Noveel Pandya: Indian multi-millionaire whose stem cell venture project is the talk of town – Gulf News

At 34, Noveel Pandya is an aspiring billionaire who has made it big right here in the UAE. Image Credit: Atiq Ur Rehman/Gulf News

Dubai: At 34, Noveel Pandya is a billionaire who has made it big right here in the UAE. While it would bealright to say he is more blessed than others his father, Narendra Pandya, ran an established business in the UAE before Noveel started Noveel is attempting to makea mark withhis own venture,Bioscience Clinic Middle East.

Senior Pandya runs a successful business House of Chemicals (HOC) - as a distributor of specialty and commodity chemicals for key suppliers especially in businesses such as oil drilling, refineries, gas plants, lubricant plants, water treatment for desalination plants and sewage treatment.

Pandya,Noveels father,also started another company BDH with an expertise in supply, installation, commissioning and maintenance of all laboratory equipment and furniture.

We are pretty much the turnkey laboratory projects expert, said Noveel, in an interview with Gulf News at his house in Emirates Hills.

But Noveels babyBioscience Clinic Middle East a center offering regenerative medicine and personalised autologous cell therapies brings him much pride and cheer. Premium services of the company include cryopreservation and expansion of cells used for anti-aging treatments, aesthetic and plastic surgery, wound care and for dermatological imperfections.

Starting from the bottom up

With a family-run business, it was perhaps a given for Noveel to become a businessman himself and run his fathers mantle.

But this was not achievedbefore he had to work his way up to the top.

In fact I started from bottom low. There was no way my father was going to have me take over peoples jobs in the company who had put in years of hard work. So there was a huge process of learning one that taught me humility and gratitude for the people who are part of our team, he said.

Noveels father came to work in the UAE in the early 70s. He said, From the stories I hear from him - there were many challenges and struggles he faced. In fact, lots of people who came with him to work in the UAE returned home.

It wasn't handed on a platter

Before jumping to the conclusion that he had it all easy,Noveel had to prove his capabilities just like any employee of the firm and had to work his way up the ladder.

There was no way my father was going to let me work above all those people who had put in so many years of service. From 2007 until 2011 it was all about learning and observation.

Take this: From the time Noveel completed his MBA in London in 2011 to join the family, he has helped the family business grow by a 100 per cent year on year.

Noveel said, BDH for example was making Dh35 million in 2007, but today, it is making over Dh140 million.

As for his own venture, there is massive potential for Bioscience Clinic Middle East as the stem cell venture business for the MENA region is tipped to be around $2 billion.

According to a report published in April 2019, the global stem cell market size is expected to reach $15.63 billion by 2025.

Today, we have little competition in the MENA region, so as you can see, there is a massive potential to grow.

Reverse-aging with stem cell therapy

Noveel said typically a client would reach out to a clinic to undergo a full scan and evaluation. A consultation with specialised doctors follows. Once the evaluation is done and the patient passes the test to become a candidate for the stem cell venture project, the doctor executes a plan to extract fat from the persons body.

This fat stores stem cells and we extract it from the fat. We have advanced technology in place to do the job for this. The stem cells derived are stored in vials and frozen, he explained.

The stem cells are multiplied to a couple of hundred million or sometimes a billion in order to produce the required volume.

Noveel said: When the stem cells are frozen they stop the ageing process of the cells. This means it effectively helps reverse-age a person. If someone at the age of 30 comes to us and asks us to freeze their cells. We do it. The person can always come back ten or 15 years later to rejuvenate their skin, hair or any part of their body.

"Just imagine at 45 or 50, this person wants to rejuvenate their skin. What we will do is inject their cells which were frozen when they were 30. When these cells are injected, they will leave the person with a skin looking as young as 30.

Stem cell therapy is said to be the most natural way to rejuvenate your skin, body and cells. The concept is called autologous which means it is your own cells which go into your body - not that of siblings or parents. Basically it is your own cells which are injected to the body and it is the most natural way to rejuvenate your body and skin.

How long does it take for the body to rejuvenate?

It depends on the body type, the persons lifestyle, food habits and more. This can take from a couple of weeks to a whole month. Remember, this is not an overnight fix. In fact treatments that come with overnight fixes can be very dangerous. Anything that has a drastic effect on your body is not good at all, explained Noveel.

We have seen fine lines or wrinkles disappearing in seven to 15 days after the cells were injected. The effect of the cell injected can last up to a year or over a year. But it all depends on the body type. Remember, your body can never reject your own cells it always accepts its cells.

Our clients are people from the age 18 and above. People who use alternative treatments come to us. I had a 63-year-old man come in from India saying they wanted their stem cells extracted.

Screening process

When a person comes there is a screening process that goes in. Upon successfully passing the screening process, other factors expel candidates like those who are typically heavy smokers or people with certain existing medical conditions.

If a client has a virus present in the body, that would drastically effect the quality of cells. If the quality of cells we get right in the beginning is poor the effect will not be desirable for them. Similarly, if the person is diagnosed with some STDs, certain terminal illness, we do not recommend them to store their cells.

Package cost

An initial package offered by Bioscience Clinic Middle East is close to Dh15,000 which includes a consultation, cell extraction, one year storage of stem cells and application. The application can be used anytime. One is not forced to use it immediately.

We are the only business in the region offering such services, Noveel claimed.

Business investment

Noveel said he invested 5 million euros in Bioscience Clinic Middle East.

This money went in for the facilitation of the lab, the treatment, and consultation, hiring skilled professionals and setting up class clean rooms for storing stem cells. Remember we are talking about a niche industry and a very niche product. The investment is for this.

Challenges as a millennial

There is a definite need to make an effort to be heard. Sometimes we are not taken seriously and that is the only challenge I see for myself today. But never give up. Keep dreaming and have the zest to grow. Patience is a virtue that we millennials need to build. Success does not come overnight. For example, my break-even did not happen for long. But I kept at my dreams and went after my goals. This is critical, Noveel said

Here is the original post:
Meet Noveel Pandya: Indian multi-millionaire whose stem cell venture project is the talk of town - Gulf News

This is the correct order to apply your skincare products – cosmopolitan.com

When it comes to establishing a skincare routine, its not always straight forward. Long gone are the days of simply cleansing, toning and moisturising. We often hear words like peptides, retinol, vitamin C, acids and serums. But what do they all mean? But more importantly which product goes first?

One rule of thumb to guide you is to apply skincare products in order of their consistency, the thinnest first finishing with the thickest. But, its not just about knowing which order to apply them, its also important to know what products you need to use and how often to use them.

According to Dr Anita Sturnham, who specialises in dermatology, our skin has a 24-hour circadian rhythm, meaning that its anatomical and physiological needs change from AM to PM. In the day your skin needs protection from external factors like sunlight and pollution, in the evening its repairing itself. Which is why you need different products for different times of the day.

Its also important not to mix certain ingredients like exfoliating treatments and vitamin C together, otherwise they can counteract one and other.

Confused much?

To save you some serious head scratching, we have put together this clear, step by step guide on which order to apply your skincare products to take out the guess work for you.

AM routine:

As youve removed your makeup the night before, begin by using a light cleanser to clear the remnants of any skincare products or excess oils left on the skin. Your morning cleanser should be gentle, hydrating and non-abrasive.

Shop now Glossier Milky Jelly Cleanser, Glossier.com, 15

Shop now CeraVe SA Smoothing Cleanser, Feelunique.com, 12

Shop now L'Occitane Gel-To-Foam Cleanser, Debenhams.com, 19

Shop now La Roche-Posay Toleriane Dermo-Cleanser, Feelunique.com, 12.50

Next, use a water-based toner to help rebalance the skins PH levels and prepare your skin for your serum and moisturiser.

Shop now Dr Barbara Sturm Balancing Toner, Cultbeauty.co.uk, 45

Shop now Neal's Yard Rejuvenating Frankincense Toner, Feelunique.com, 20

Shop now Fresh Rose Deep Hydration Facial Toner, Cultbeauty.co.uk, 21

Shop now Caudale Beauty Elixir, Lookfantastic.com, 12

Follow by using an eye cream. Its important to use a separate eye cream because the skin around the eye area is a lot thinner and more sensitive than the rest of face. This is why its more prone to ageing over time, so using a hydrating eye cream rich in ingredients like hyaluronic acid and peptides help to boost collagen levels in the under eye area.

Shop now Vichy Minral 89 Eyes, Feelunique.com, 20

Shop now Clinique Moisture Surge Eye Concentrate, Lookfantastic.com, 27.50

Shop now Avne Soothing Eye Contour Cream, Lookfantastic.com, 9.50

Shop now Drunk Elephant C-Tango Multivitamin Eye Cream, Cultbeauty.co.uk, 54

Hyaluronic Acid is a key skincare ingredient which can be used by all skin types, according to Dr Sturnham: hyaluronic acid helps to provide structure to our cells and supports our skins hydration barriers. This extra hydration therefore helps to plump to the skin, minimising the appearance of fine lines.

In order to reap the maximum benefits, Dr Sturnham recommends applying hyaluronic acid in small layers throughout your morning and evening skincare routine, as well as using as a separate serum.

Shop now The Ordinary Hyaluronic Acid 2% + B5, Lookfantastic.com, 5.90

Shop now SkinCeuticals H.A. Intensifier, Lookfantastic.com, 85

Shop now Evolve Organic Beauty Hyaluronic Serum, Feelunique.com, 12

Shop now The Inkey List Hyaluronic Acid, Feelunique.com, 5.99

A serum is designed to penetrate the deeper dermal layers of your skin and nourish it with a variety of skin protective ingredients. Layering serums can also be effective to adapt your skincare routine to your specific skin needs.

Dr Sturnham recommends layering serums that have these key ingredients to promote healthy skin throughout the day:

Vitamin C - Vitamin C is an essential nutrient rich ingredient that should be used daily in your skincare routine. Our skin has built in receptors for Vitamin C says Dr Sturnham, which is why it is key to ensure we get our daily skincare fix of it. Vitamin C has many benefits such as improving skin tone, protecting the skin against pollution and UV damage, boosting cell repair and giving the skin a radiant look.

Panthenol (Vitamin B5) - Panthenol otherwise known as Vitamin B5 is an ingredient that helps to soften and soothe the skin by helping (repetition of skin) protect against irritation and water loss.

Ferulic Acid - Ferulic Acid is an antioxidant which helps to boost the effects of other antioxidants used in serums. It also helps to reduce signs of ageing like fine lines and wrinkles.

Shop now Decree Peptide Veil +, Cultbeauty.co.uk, 115

Shop now Paula's Choice C15 Super Booster, Lookfantastic.com, 46

Shop now Medik8 Hydr8 B5, Facethefuture.com, 32

Shop now The Ordinary Vitamin C Suspension 23% + HA Spheres 2%, Cultbeauty.co.uk, 4.90

Once you have applied your serum and given it time to absorb into the skin, it is then time to apply a moisturiser. This helps to hydrate your skin throughout the day and creates a smooth base for makeup. Dr Sturnham recommends non pore-clogging ingredients like safflower, apricot kernel and squalene.

Shop now Kate Somerville Goat Milk, Cultbeauty.co.uk, 55

Shop now Clinique Dramatically Different Hydrating Jelly, Feelunique.com, 31

Shop now Glossier Priming Moisturiser, Glossier.com, 18

Finish by using an SPF (Sun Protection Factor) to protect your skin against UV damage. UV damage causes signs of premature ageing such as wrinkling and pigmentation. Experts recommend using an SPF30 or higher on your face to deliver optimum UV protection.

Shop now REN Clean Screen Mineral SPF 30, Lookfantastic.com, 30

Shop now Kiehl's Ultra Light Daily UV Defense, Feelunique.com, 28

Shop now Vichy Ideal Soleil Mattifying Face Fluid Dry Touch SPF30, Feelunique.com. 16.50

Shop now SkinCeuticals Ultra Facial Defense SPF50+, Lookfantastic.com, 37

PM routine

For your evening cleanser use something with more active ingredients that has an exfoliation to it and that is deep pore cleansing. If you are wearing makeup and SPF during the day, we recommend double cleansing: using a balm or oil based cleanser first to breakdown the makeup and excess oil and following with a gentle, hydrating gel cleanser.

Shop now Emma Hardie Amazing Face Moringa Cleansing Balm, Lookfantastic.com, 47

Shop now The Body Shop Oils of Life Cleansing Oil-in-Gel, Thebodyshop.com, 12

Shop now Decree Deep Cleanse, Cultbeauty.co.uk, 55

Shop now DHC Deep Cleansing Oil, Feelunique.com, 11

Once again follow with a toner to balance your skins PH levels and prep your skin for your serum and moisturiser. You can also opt to use an acid toner two to three times a week depending on your skin type. Look for ingredients like glycolic acid, lactic acid and mandelic acid which will exfoliate the skin and even texture.

Shop now Dr Dennis Gross Alpha Beta Ultra Gentle Daily Peel, Lookfantastic.com, 87

Shop now Pixi Glow Tonic, Lookfantastic.com, 18

Shop now Nip & Fab Glycolic Fix Daily Cleansing Pads, Lookfantastic.com, 12.95

Shop now Paula's Choice 2% BHA Liquid Exfoliant, Lookfantastic.com, 28

If you are really invested in fighting signs of ageing and those pesky fine lines, retinol is the way to go. Otherwise known as vitamin A, retinol is a rich ingredient which helps to fight signs of ageing at a deep cellular level. It helps to promote the production of collagen and elastin, reduce pore congestion, regulate the production of sebum and work against inflammation.

There are many options for retinol on the market, but Dr Sternham recommends using retinol into your skincare routine in the form of a serum. Look for words like: granactive Retinoid or hydroxypinacolone retinoate which are less harsh on the skin.

Use it in small doses every night after cleansing and toning before applying your moisturiser and built up gradually. Make sure that you always use an SPF in your morning routine, as retinol will make your skin more photosensitive.

Shop now Medik8 Crystal Retinal 1, Facethefuture.com, 39

Shop now Elizabeth Arden Retinol Ceramide Capsules, Lookfantastic.com, 42

Shop now Drunk Elephant A-Passioni Retinol Cream, Cultbeauty.co.uk, 62

Shop now Disciple Dreamy Skin, Cultbeauty.co.uk, 35

Like your AM routine, follow up with an eye cream to the orbital bone area. We recommend saving yourself some money and opting for the same one morning and night.

Add a serum to your PM skincare routine like you would before a moisturiser in the day. Dr Sturnham advises to look for ingredients that support your skins physiological needs at night. Pay attention to how your skin is feeling, is your skin dry? Is it showing signs of pigmentation? Is your skin feeling congested? Look for serums that will address the particular needs of your skin and that ideally have a variety of skin benefiting ingredients. Dr Sturnham recommends ingredients like alpha arbutin, hyaluronic acid and plant-based stem cells.

Shop now Kate Somerville KX Active Concentrates Ceramides & Omegas, Spacenk.com, 84

Shop now Bybi Supercharge Serum, Feelunique.com, 32

Shop now The Ordinary Alpha Arbutin 2& + HA, Cultbeauty.co.uk, 7

Shop now Glossier Super Bounce, Glossier.com, 24

For your evening moisturiser use one with a slightly richer, thicker consistency than you would during the day to hydrate dehydrated skin.

Shop now Trilogy Replenishing Night Cream, Lookfantastic.com, 32.50

Shop now Herbivore Moon Fruit Night Treatment, Cultbeauty.co.uk, 48

Shop now CeraVe Moisturising Lotion, Lookfantastic.com, 9

Always Remember

-Avoid using exfoliating or foaming cleansers followed by alcohol-based toners, as this will dry out skin, making it prone to sensitivity.

-Take your time to apply each product, allow each layer to absorb into the skin before applying the next one.

-Use your treatment products in order of their consistency from lightest to thickness.

-Avoid mixing water-based and oil-based products in your same skincare regime.

-Keep your cleansing routine simple on a daily basis and reserve the more intensive exfoliation routine for once a week.

-Avoid using intensive exfoliators with Vitamin C.

Follow Emily on Instagram.

Originally posted here:
This is the correct order to apply your skincare products - cosmopolitan.com

German Beauty Brands to Try This Oktoberfest and Beyond – STYLECASTER

Scroll To See More Images

Its safe to say that we are in a total German state of mind lately. And now that Oktoberfest is here, we are more than appreciative of the delicious international fare the season always brings. However, wed be foolish not to reflect on the awesomeness that is German beauty brands this month, especially since it seems to be having a major moment in 2019.

And while you may be trying to picture just how G-Beauty could ever dethrone the beauty behemoth that is K-Beauty, Martina Joseph, CEO of German brand Dr. Hauschka USA, explains that the German beauty scene is here to stay, especially since it has a strong emphasis on high-quality products and standards. Germany has a brilliant reputation for quality products and quality standards, says Joseph. The consumer is recognizing the value proposition of clean ingredients, and are seeking clean, sustainable, and responsible products.

And clean beauty factor aside, theres no denying that G-beauty is also popular due to its kind international appeal. Besides, we all know how popular French girl beauty still is to this day. To help you say hallo to the best German beauty brands, we rounded up nine skincare and makeup companies worth keeping on your radar. From drugstore-favorites to luxurious brands worth investing in, check out our top brand picks just in time for Oktoberfest below.

Dr. Hauschka may have an impressive roster of celebrity fans (including starlets like Anne Hathaway and Julia Roberts) to brag about, but its definitely for good reason, as this German skin-care brand utilizes natural ingredients to help improve the performance of your skin.

And aside from the cleansing, moisturizing, and nighttime needs the brand offers, its worth mentioning that Dr. Hauschkas toning products are equally exceptional. Dr. Hauschkas original facial toner, for example, is nothing short of a skin-care superstar, as it utilizes a potent blend of anthyllis and witch hazel extracts to gently clarify the skin.

$37 at Dermstore

Created by German dermatologist Dr. Tim Golueke, this luxurious line of anti-aging products has already found some firm footing in the states, as its currently sold at retailers like Bergdorf Goodman. But, dont let its hefty price tag fool you into thinking its just another cash grab, as this revolutionary brand utilizes unique ingredient Royal Fern (an extremely moisturizing evergreen plant thats also resistant to environmental influences) to combat skin aging on all levels.

The brands anti-aging anti-aging serum definitely uses a special Royal Fern Complex (plus hyaluronic acid and vitamin C from Acerola cherry) to protect the skin against genetic and environmental stress, making it a must for those who are looking to add an anti-aging alternative to retinol to their routine.

$295 at Violet Grey

This German skin-care brand is definitely a clean beauty enthusiasts dream, as each product contains minimally processed ingredients that dont contain preservatives, solvents, and surfactants. And while we are very impressed by Less amazing line of hairbrushes, theres no denying that the brands skin-care essentials are a must-see.

The Less Face Oil for Dry Skin, is one of the products we cant stop talking about, as it utilizes a blend of avocado, jojoba, and apricot oils for supple and moisturized skin.

$72 at Less

Seoul isnt the only authority on sheet masks now that this German skin-care brand has entered the fold, as it also delivers budget-friendly products that address all your skin woes. And sheet masks aside, Magicstripes has also unveiled some eye-raising products that have garnered media here in the United States. The brands eyelid lifting strips, for example, have been featured in outlets like Allure, making it something to see for yourself, should you be curious.

However, if sheet masks are practically your main squeeze, you really cant go wrong with this hyaluronic acid-infused product, as it leaves your skin feeling oh-so-hydrated in a matter of minutes.

$15.52 at MagicStripes

Combining revolutionary science with biological wisdom, this line of products was developed by German-born professor Augustinus Bader, who is globally recognized as one of the leading voices in regenerative medicine. And what makes this line of products unique is the innovative science behind it, as professor Bader studied how to perfect the skins healing process for up to 30 years. This same research ultimately led him to discover how to unlock the signals that trigger ones own stem cells.

Professor Bader initially applied his research to develop a special wound gel for severe burn victims. However, since the gel delivered remarkable results, it then inspired a full line of skin and body products to support the skins natural healing process. The anti-aging Augustinus Bader Body Cream is definitely one of the major highlights of this skin-care collection, as it drenches dehydrated skin in essential moisture.

$165 at Augustinus Bader

Hailing all the way from Frankfurt, this German beauty brand boasts an impressive line of high-quality brushes, palettes, lipsticks, and foundation products. However, you dont have to be based in Germany to score ZOEVA products, as the brands Authentik Skin Foundation is set to debut at Ulta later this month.

And unlike some drying foundations on this market, expect this rosehip oil-infused product to leave your skin feeling silky smooth upon application.

$28 at Ulta

NIVEA surprisingly has some strong German roots, as the brand was founded in 1882 by German physicist Paul Carl Beiserdorf. And while NIVEA products are definitely found abroad, youll love to know that they are pretty easy to find here in the states as well.

Drugstores like CVS and Walgreens, for example, actively carry Nivea products, making them an absolute must if you are looking to give your skin the TLC it deserves.But, if you are a newbie to the brand, we strongly recommend investing in the brands highly moisturizing cucumber body wash.

$6.49 at CVS

Founded by German aesthetics doctor, this sophisticated line of skin-care products (think creams, serums, and facial scrubs) has gained quite the celebrity fanbase. However, starpower isnt the only thing thats driving Dr. Barbara Sturms popularity onward and upward, as its innovative ingredient science is also worth buzzing about.

Apart of that science includes focusing on utilizing unique and powerful ingredients, as the brands full skincare range utilizes Purslane, an anti-aging powerhouse that helps calm down inflammation. If you are extra curious about adding Purslane to your routine, trust that Dr. Sturms new Skin Food supplement definitely uses this superstar ingredient (plus other skin-boosting antioxidants!) to help rehabilitate and protect your complexion.

$95 at Sephora

This affordable beauty brand also has some German roots, as its earliest origins stem back to 2004, when it was founded by Christina Oster-Daum. Flashforward to 2019, and its safe to say that Catrice has become nothing short of a global sensation, as its line of affordable makeup products can easily be found at American beauty retailers like Ulta.

Catrices HD Liquid Coverage Foundation surely is a product to consider if you are looking for affordable foundations, as it retails for just $10.99, and delivers long-lasting coverage.

$10.99 at Ulta

Our mission at STYLECASTER is to bring style to the people, and we only feature products we think youll love as much as we do. Please note that if you purchase something by clicking on a link within this story, we may receive a small commission of the sale.

Read more here:
German Beauty Brands to Try This Oktoberfest and Beyond - STYLECASTER

Central nervous system graft-versus-host disease in a 68-year-old man presenting with myoclonus – CMAJ

KEY POINTS

Although graft-versus-host disease is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation, involvement of the central nervous system in this disease is uncommon.

In patients with a previous hematopoietic stem cell transplantation presenting with neurologic manifestations, central nervous system graft-versus-host disease should be on the differential diagnosis.

Diagnosis of central nervous system graft-versus-host disease relies on exclusion of other infectious, autoimmune, vascular, drug-related and paraneoplastic processes, along with compatible imaging and histopathologic findings.

The primary treatment of central nervous system graft-versus-host disease is immunosuppression with high-dose corticosteroids.

A 68-year-old man presented to the emergency department with a 1-week history of sudden-onset myoclonus of his right leg. His medical history included allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome performed 742 days earlier, type 2 diabetes mellitus, hypertension and dyslipidemia. The patient had undergone a 9/10 unrelated human leukocyte antigen (HLA) donor transplantation, and after transplantation, his myelodysplastic syndrome was in complete remission and he had complete donor engraftment. On presentation, he was receiving methotrexate (10 mg by mouth weekly) for large granular lymphocytosis and acyclovir (400 mg by mouth twice daily) for herpes simplex virus prophylaxis. A detailed neurologic examination on presentation showed a right-sided pyramidal distribution of weakness and a stimulus-sensitive, spontaneous positive myoclonus, present in the right leg more than the arm, and absent in the face. Deep tendon reflexes were brisk on the right side.

Given this patients history of hematopoietic stem cell transplantation and relative immunosuppression with methotrexate, the differential diagnosis was broad and included central nervous system infections, central nervous system relapse of his primary malignancy, metabolic derangements, paraneoplastic process, microangiopathy, central nervous system vasculitis, toxicity related to immunosuppressive agents, and central nervous system graft-versus-host disease. On further history, it was noted that he received a reduced intensity conditioning transplantation with fludarabine, busulfan and total body irradiation of 200 Gy. His graft-versus-host disease prophylaxis was with anti-thymocyte globulin, and posttransplantation cyclophosphamide and cyclosporine.1

The patient was admitted to the internal medicine service, and neurology was consulted, given his neurologic findings. Magnetic resonance imaging (MRI) of the brain showed multiple scattered T2-weighted fluid-attenuated inversion recovery hyperintense, non-enhancing, mildly expansile, cortical and subcortical lesions in both cerebral hemispheres, with no associated restricted diffusion (Figure 1AD).

Axial magnetic resonance imaging of the brain in a 68-year-old man with myoclonus after allogeneic hematopoietic stem cell transplantation. Pretreatment (A) T2-weighted fluid-attenuated inversion recovery (FLAIR), (B) T1-weighted postgadolinium, (C) diffusion-weighted and (D) apparent diffusion coefficient mapping images showing multiple scattered cortical and subcortical non-enhancing T2 and FLAIR hyperintense lesions (arrowheads) throughout the supratentorial brain. The lesions did not show restricted diffusion by diffusion-weighted imaging and apparent diffusion coefficient mapping. Posttreatment with corticosteroids, (E) T2-weighted FLAIR, (F) T1-weighted postgadolinium, (G) diffusion-weighted and (H) apparent diffusion coefficient mapping images show resolution of lesions.

Over the following days, the patient had a rapid neurologic deterioration. He became nonverbal, and his only preserved motor function was smooth pursuit eye movements. Given this rapid progressive encephalopathy, the patient was treated empirically for viral encephalitis with acyclovir (800 mg intravenously every 8 hours). Despite this treatment, the patients clinical condition did not improve. Lumbar puncture showed a protein level of 0.53 (normal 0.20.45) g/L, a glucose level of 3.7 (normal 2.54.5) mmol/L and no pleocytosis. Microbiological and molecular analysis did not show any evidence of causative infectious pathogens; the analysis included an extensive panel of bacterial, viral (EpsteinBarr virus, cytomegalovirus, polyomavirus, varicella zoster, herpes simplex, human herpesvirus 6, rubella, measles, West Nile virus and arbovirus), parasitic (toxoplasmosis), prion (CreutzfeldtJakob disease) and fungal (Cryptococcus) infections. Electroencephalography showed diffuse slow wave activity corresponding to nonspecific encephalopathy but did not show any epileptogenic focus. There was no evidence of malignant cells on cerebrospinal fluid cytopathology and flow cytometry. A vasculitis panel including cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA), perinuclear ANCA (p-ANCA), antinuclear antibodies, anti-double stranded DNA, C3, and C4 was negative. Testing for antibodies for paraneoplastic syndrome was negative. Methotrexate-induced leukoencephalopathy, classically seen in patients receiving high-dose methotrexate, especially intrathecally, was included in the differential diagnosis. However, the patients MRI findings were inconsistent owing to sparing of the centrum semiovale, as well as a lack of restricted diffusion.2 Furthermore, his symptoms persisted despite discontinuation of methotrexate.

Given worsening of the patients clinical condition and radiographic findings despite 10 days of treatment with intravenous acyclovir, a brain biopsy of the left frontal parietal cortical lesion involving both grey and white matter was performed. This showed perivascular lymphocytic infiltrate (Figure 2A). Luxol fast blue stains showed the absence of demyelination (Figure 2B). There was evidence of microglial activation involving the neuropil and perivascular spaces, highlighted by CD163 immunostains (Figure 2C). A sparse CD3 positive T lymphocyte perivascular infiltrate was present, without direct infiltration of the vessel wall (Figure 2D). There were no CD20 positive B lymphocytes. The pathologic findings of perivascular infiltrate were consistent with literature reports of central nervous system graft-versus-host disease. Investigations looking for other sites of involvement including liver enzymes, cutaneous examination and endoscopy, although not exhaustive, did not show graft-versus-host disease of other organs.

Histopathologic images of the patients frontal cortex biopsy. (A) Hematoxylin and eosin staining showing sparse perivascular lymphocytic infiltrate in the white matter (arrowheads). (B) Luxol fast blue staining showing the absence of demyelination. (C) Perivascular activated microglia as shown by CD163 staining (arrowheads). (D) T lymphocytes infiltrating perivascular spaces (black arrowhead) and the neuropil (green arrowhead) as shown by CD3 staining. Scale bar = 200 m.

Even with this extensive workup, the patients diagnosis was unclear. It was imperative that infectious causes were considered and ruled out, which we had done. Given the patients clinical deterioration, a presumptive diagnosis of central nervous system graft-versus-host disease was made, and an empirical course of corticosteroid pulse was started (methylprednisolone 150 mg/d intravenously). Clinical improvement was rapid, and by day 3 of corticosteroid therapy, the patient was able to move his limbs and vocalize. He continued to improve and was ambulatory within 2 weeks of treatment. Repeat MRI showed resolution of many of the lesions (Figure 1EH). The patients dosage was subsequently tapered, and he was transitioned to maintenance prednisone (60 mg/d by mouth) and azathioprine (75 mg/d by mouth).

Unfortunately, recurrent infections developed while the patient was receiving immunosuppressive treatment. Three months later, as his prednisone was tapered, he again had a flare of neurologic symptoms, and MRI showed worsening of the lesions. The patients goals of care were changed to comfort measures, and he died 927 days after the transplantation and around 195 days after onset of the central nervous system symptoms.

Allogeneic hematopoietic stem cell transplantation is a life-saving treatment for many hematologic diseases. Graft-versus-host disease is a leading cause of morbidity and mortality after allogenic hematopoietic stem cell transplantation.3 Between 30% and 50% of patients will develop graft-versus-host disease, whereby the donated tissue (the graft) recognizes the recipient (the host) as foreign and mounts a T cellmediated immune response.4 The clinical manifestations vary, as multiple organs can be affected.

Classification of graft-versus-host disease has traditionally been divided into acute and chronic, depending on the onset of symptoms within or beyond 100 days, respectively. However, recent criteria consider overlap syndromes with increased emphasis on clinical features rather than timing of symptom onset alone.5,6 Central nervous system graft-versus-host disease is a rare but emerging entity after allogeneic hematopoietic stem cell transplantation, probably in part because the number of hematopoietic stem cell transplantations has risen.79

Although chronic graft-versus-host disease can affect any organ, the skin, gastrointestinal tract, liver, joints, fascia and lungs are most frequently affected. Signs and symptoms of graft-versus-host disease relate to the organs of involvement, including maculopapular rash, hyperbilirubinemia with jaundice, and abdominal pain with either nausea and vomiting or diarrhea.4 With such broad-ranging clinical features, diagnosis relies on the assessment of target organs by means of clinical, laboratory and pathological findings. Important risk factors include compatibility of recipient and donor, including degree of HLA mismatch, sex of donor and recipient, use of peripheral-blood stem cell grafts and the conditioning regimen used. Criteria from the National Institutes of Health (NIH) help in defining and stratifying chronic graft-versus-host disease.10 Because of the rarity of cases, central nervous system graft-versus-host disease is not defined in the NIH criteria.

Neurologic involvement (first documented nearly 3 decades ago11) is rare, and graft-versus-host disease afflicting both the central and peripheral nervous system has been described in the literature.79 Symptoms involving the central nervous system are often nonspecific and can include headaches, altered mental status, seizures and paresis.

In a recent case report and review, Ruggiu and colleagues reported a total of 39 presumed cases of central nervous system graft-versus-host disease, with a median patient age of 35 (range 0.6768) years and a median duration of symptomatic presentation of 385 (range 77320) days after transplant.8 In this case series, which is limited by a lack of histopathology in more than half of the patients, those presenting with central nervous system disease without other chronic features of graft-versus-host disease presented earlier and in most cases had a history of acute graft-versus-host disease.8

Our patient did not present with evidence of extracentral nervous system graft-versus-host disease. This may be owing to the newer conditioning regimen he was given, immunosuppression, or other underlying medical diagnoses and comorbidities. Our current lack of understanding of the clinical course of patients with central nervous system graft-versus-host disease highlights the importance of further research into identifying risk factors, developing better diagnostic tools and finding new strategies for prevention.

The diagnosis of central nervous system graft-versus-host disease is complicated by conflicting differential diagnoses that can be challenging to exclude, such as infection, drug and radiation toxicity, and primary disease metastasis. As such, a combination of microbiologic and laboratory studies, and radiographic and histopathologic findings are required for the workup.

Given these diagnostic challenges, the 2009 Consensus Conference on Clinical Practice in chronic graft-versus-host disease defined the neurologic manifestations of the disease.5 This definition included the following criteria: 1) occurrence with chronic graft-versus-host disease affecting other organs, 2) neurologic signs of central nervous system involvement without other explanation, 3) corresponding MRI brain abnormality, 4) abnormal cerebrospinal fluid findings, 5) brain biopsy or postmortem examination confirming graft-versus-host disease and 6) response to immunosuppressive therapy.5 Criteria 1 and 2 are considered mandatory requirements in the diagnosis of central nervous system graft-versus-host disease, whereas criteria 36 are facultative requirements. A definitive diagnosis can be made when all 6 criteria are met, and a possible diagnosis can be made when both mandatory criteria and at least 2 facultative requirements are met.

Our patient met all the criteria according to this consensus definition except the first (occurrence with chronic graft-versus-host disease affecting other organs). Interestingly, the case series by Ruggiu and colleagues showed that 28% of patients did not have extracentral nervous system features of chronic graft-versus-host disease, although most of these patients did have a history of extracentral nervous system acute graft-versus-host disease.8

Despite immunosuppressive treatment, central nervous system graft-versus-host disease portends a poor prognosis. Prior case series show that even though 70% of patients who received treatment with corticosteroids showed at least a partial response, only 18% of patients were alive at last follow-up.8

This case highlights the importance of the late central nervous system complications of hematopoietic stem cell transplantation, the challenges with diagnosis and the role of timely immunosuppressive therapy. Though concepts regarding central nervous system graft-versus-host disease continue to evolve, it is important to keep as a differential diagnosis in patients with noninfectious neurologic complications who have undergone hematopoietic stem cell transplantation.

The authors acknowledge the contributions of Russell Yanofsky, Sunu Cyriac, David G. Munoz and Auro Viswabandya.

Competing interests: None declared.

This article has been peer reviewed.

The authors have obtained patient consent.

Contributors: The authors all contributed substantially to the conception of this work, including acquisition, analysis and interpretation of raw patient data in the form of clinical examination findings or laboratory investigations on the patient. All authors were substantially involved in drafting and editing the work, including substantial contributions in their respective areas of expertise and in review of the contributions of the other authors. All authors give their final approval of the version to be published and agree to be accountable for all aspects of this work.

The rest is here:
Central nervous system graft-versus-host disease in a 68-year-old man presenting with myoclonus - CMAJ

New Insight as to How Cells Maintain Their Identity – Nature World News

Sep 21, 2019 10:17 AM EDT

In the body's cells, some proteins are of vital importance as to which genes are active or turned off. Now, researchers from the University of Copenhagen and the Memorial Sloan Kettering Cancer Center have discovered which proteins are necessary in order to maintain the proper genetic regulation.

All of the more than 200 different cell types in our body contain the same DNA. Which of those genes that are expressed determine each cell type. Therefore, it is essential that the activity of the genes is controlled with great precision.

Thus, a stem cell may develop into anything from skin to a bone cell, depending on which parts of the genome that are expressed.

The researchers in Professor Kristian Helin's research group have for several years worked to understand the mechanisms that control whether a gene is active or inactive. This research is crucial to the understanding of how cells become specialized and maintain their identity, the normal embryonic development, and how various diseases may develop.

In a new study, researchers working at the Biotech Research & Innovation Center (BRIC) and the Novo Nordisk Foundation Center for Stem Cell Biology (DanStem) at the University of Copenhagen as well as the Memorial Sloan Kettering Cancer Center in New York have achieved crucial new results.

The results were recently published in the scientific journal Molecular Cell and provide insight into the ways in which epigenetic mechanisms control the activity of genes.

'In addition, the results may have an impact on the future treatment of certain cancers related to the studied protein complex, including lymphoma, leukemia and a special type of brain cancer that is often seen in children', says Kristian Helin, Professor at BRIC and Director of Research at the Memorial Sloan Kettering Cancer Center.

Turning On and Off

One of the key protein complexes that regulate whether genes are turned on or off is called PRC2. To ensure that the complex binds to the right places in the genome, a number of other proteins are associated with PRC2.

In the recently published article, the research group has studied the importance of six different proteins associated with PRC2, and the group has shown that all six proteins help direct PRC2 to the right places in the genome.

In 15 different combinations, the researchers removed the associated proteins from embryonic stem cells one by one. In this way, the researchers were able to study the contribution of each protein to the activity and binding of the PRC2 complex to specific areas. It was found that the ability to find the way to the right places in the genome remained intact until all six associated proteins were removed from the stem cells.

That finding surprised the researchers, says the study's lead author, Postdoc Jonas Hjfeldt:

'We assumed that each of the associated proteins was responsible for its own area to where the PRC2 complex should be guided. Instead, we saw that they all contributed to the places where the complex binds. As long as just one of the associated proteins were left, the ability remained intact', he says.

2018 NatureWorldNews.com All rights reserved. Do not reproduce without permission.

See the article here:
New Insight as to How Cells Maintain Their Identity - Nature World News

You can now use plant stem cells to rejuvenate your skin – Fashion Journal

Youll be glowing.

Skincare brand Andalou has introduced a new product line to its naturally-derived offering, citing hemp as a total skin saver.

The brand formulates its innovative products around fruit stem cell science, which utilises antioxidants that occur in apples, grapes and other natural ingredients.

For the new CannaCell range, stem cells are extracted from the stalk of hemp plants and included in each product along with organic hemp seed oil.

While the vitamin and protein-rich oil helps soothe distressed skin and boost water retention, the stem cells work to prevent oxidative damage, and counteract sun exposure and pollution.

Leading the pack for the new line is Andalous CannaCell Glow Mask. The exfoliating, botanical enzyme-based mask has a jelly-like consistency and warms the skin while it works its magic.

Then, after a relaxing 10-20 minutes, youll find your skin hydrated, soothed and glowing.

The CannaCell range is available online now.

@andalounaturals_au

See original here:
You can now use plant stem cells to rejuvenate your skin - Fashion Journal

Reported stem cell treatment could give hope to Michael Schumacher – Stuff.co.nz

The news that Formula One legend Michael Schumacher was moved to a hospital in Paris last week for pioneering stem cell therapy has provoked a fever of hope and speculation among fans that his condition could be improved.

After suffering devastating head injuries in a ski accident almost six years ago, Schumacher was placed in a coma for six months and has been receiving treatment at his home in Switzerland. He has not been seen in public since the accident.

His privacy is closely guarded and, while it is understood he cannot walk or stand, and, according to former Ferrari manager, Jean Todt, he may still have trouble communicating, nothing has been confirmed officially.

No wonder then that fans have been so excited to hear Schumacher is now under the care of world-renowned cardiac surgeon Philippe Menasch, described as a "pioneer in cell surgery" at the Georges-Pompidou hospital in Paris.

READ MORE:* Schumacher 'conscious' after treatment*Corinna Schumacher provides rare update*Schumacher 'struggles' to communicate*Mick Schumacher trying to emulate his dad

Stem cells are cells that can differentiate or change into other types of cell, opening the possibility of replacing damaged cells with healthy ones. Scientists have been looking into their use since the Sixties, most successfully so far in cases of cancers of the blood or bone marrow. More than 26,000 patients are treated with blood stem cells in Europe each year.

And since the Eighties, skin stem cells have been used to grow skin grafts for patients with life-threatening burns; most recently, a new stem cell-based treatment to repair damage to the cornea (the surface of the eye) after an injury like a chemical burn, has received conditional approval in Europe.

But their flexibility offers hope for lots of illnesses and conditions including heart disease, MS and macular degeneration and clinical trials are progressing in all these areas. Chronic spinal cord injury is being researched with some promise, thanks to the Christopher & Dana Reeve Foundation, set up after actor Christopher Reeve was paralysed in a riding accident.

Crucially, for cases such as Schumacher, stem cells are also being explored for neurodegenerative diseases like Parkinson's and Alzheimer's and traumatic brain injuries like the one he suffered in a skiing accident in December 2013.

Head injuries are difficult to treat as brain damage cannot be undone and each case is different. Asked for comment by The Daily Telegraph, the hospital responded that they could neither confirm nor deny the presence of Schumacher.

However, if he is under the care of Menasch, it is likely he will have had stem cells delivered by an IV to the area of the body where it is felt they could work best - whether that is his head or heart.

CHRISTOPHE ENA/AP

Paris' Georges-Pompidou Hospital, where Michael Schumacher is reportedly a patient.

In a recent interview online, Menasch explained that stem cell treatment for cardiac conditions - his particular area of expertise - is in its infancy. "Nobody really knows how stem cells are working," he said. "They do not permanently transplant into the myocardium [the muscular tissue of the heart] - after a couple of days or weeks, they just disappear.

"But you still may have a functional benefit as during their transient stay in the heart," he explains in the Future Tech podcast, "as the cells release molecules into the tissue. The hypothesis is that the repair comes from the heart itself, stimulated by these molecules."

Should the stem cells have been intended for Schumacher's brain injury, research suggests that the treatment has potential. A University of Plymouth study published in the journal Cell Reports in June found that neural stem cells could be used to "wake up" and produce new neurons (nerve cells) and surrounding glial cells in the brain.

The research is in its infancy, says lead author Dr Claudia Barros, from the Institute of Translational and Stratified Medicine at the University of Plymouth, who acknowledges there is still a long way to go until such findings can be translated into human treatments.

"We are working to expand our findings, to bring us closer to the day when human neural stem cells can be controlled and efficiently used to facilitate brain damage repair, or even prevent brain cancer growth that is fuelled by stem-like cells," she says.

A Chinese study published last month in the journal Frontiers in Cellular Neuroscience examined the current state of progress into the effects of stem cell therapy on traumatic brain injury. But the researchers from Zhejiang University, Hangzhou warned much more work was needed: "Although a large number of basic studies have confirmed that stem cells have good effect in the craniocerebral injury," they said, "the safety of stem cells, the route of injection, the time of injection and the specific mechanism are all factors that affect the clinical application of stem cells, and are the important research point in the future study."

PREMA TEAM

Mick Schumacher doesn't mind the comparisons with his seven-time F1 champion father Michael.

In the UK, some applications of stem cell medicine are already available privately, although tightly controlled by the Human Tissue Authority and not in the brain.

Simon Checkley, CEO at the Regenerative Clinic in Brighton, explains: "It is possible to get stem cells from sources outside your body, like the umbilical cord or Wharton's jelly [the vitreous humour in the eyeball], but in the UK we can only take stem cells from our own bodies.

"It is possible to get them donated, but it is safer to use your own."

In some countries, stem cells can then be manipulated in a laboratory but that is illegal in the UK, says Checkley. "There is a concern with cultured stem cells which have been bred in a Petri dish that they may keep proliferating after you transplant them into a body. That, having triggered their growth, you can't stop it and no one knows what might happen."

At the Regenerative Clinic, stem cells are taken from adipose fat, where they are plentiful, and then injected back into the area to be treated - mostly arthritic joints.

"We are seeing fantastic results," Checkley says, "with reduced pain and improved mobility for 80 per cent of patients." He is considering a clinical trial which could see the treatment pass through the National Institute for Health and Care Excellence (NICE) and become available on the NHS.

The therapy is still only four years old, he emphasises. "We have treated 1000 patients so far and around the world, it's about 40,000. We need longer-term studies."

LUCA BRUNO/AP

Michael Schumacher has not been seen in public since suffering a serious brain injury in a skiing accident nearly six years ago.

This type of stem cell treatment is also offered in the UK for post-menopause vaginal atrophy and stress incontinence, Checkley says, plus the genital skin condition lichen sclerosis. In all these cases, he says, the mechanism is the same: the stem cells are not replicating dead or dying cells but acting as signalling devices, alerting the body that this is an area where healing is needed.

For stem cells to work in more complex conditions, they would need to be manipulated, Checkley says. In cases of brain injury or disease, that would mean altering stem cells so that they could be targeted more precisely. But he believes the role would be similar: "The idea is they would go to the area of greatest damage and signal the body to regrow tissue there."

Cost would be a huge factor, he points out. A treatment for arthritis costs about 6000 (NZ$11,700) at the Regenerative Clinic but an IV-led treatment for brain injury with manipulated stem cells could cost up to 50,000 (NZ$98,000). But then what price recovery from a traumatic brain injury? Full recovery thanks to stem cells would be a prize beyond value.

See original here:
Reported stem cell treatment could give hope to Michael Schumacher - Stuff.co.nz

Regulatory heft needed to curb false promises on stem cells, says health law expert – Folio – University of Alberta

The legal and regulatory tools designed to protect the public from the marketing of unproven stem cell therapies will remain ineffective without bureaucratic will and grassroots efforts, according to a University of Alberta health law expert.

There's this perception that stem cells are revolutionizing science and they have transformed medicine already, but that's just not the case, said Timothy Caulfield.

You see the word stem cells being used to sell everything from skin cream to sports recovery tools to supplements, it's absolutely everywhere.

Caulfield, who refers to the marketing of spurious stem cell treatments as scienceploitation, explained there are actually only a handful of such therapies that have been approved for use in a clinical setting.

The most well known is probably the use of stem cells in bone marrow transplants and certain kinds of leukemiabut these therapies have been around for decades, he said, adding other stem cell therapies have shown some effectiveness in the treatment of bad burns and blindness.

But that's it.

In a paper outlining a strategy to combat the spread of misrepresentation within this field, Caulfield and Health Law Institute research associate Blake Murdoch argued the first step is to leverage the powers wielded by the provincial colleges of physicians and surgeons.

We need a more robust response from them because they have the power to stop their members from marketing treatments inappropriately and from offering services that are unproven, said Caulfield.

We haven't seen that, and it really is their role to protect the public.

He added organizations aimed at stopping the spread of misinformation and inaccurate marketinglike Ad Standards, Canadas advertising industry's non-profit self-regulating body, or Competition Bureau Canada, the federal advertising regulatorcan also be more involved.

While the Competition Bureau can only prohibit clinics from using misleading advertising and

not the provision of unproven interventions, this would help to stop the spread of misinformation, which may curtail public interest, said Caulfield.

He added political pressure on federal and provincial lawmakers could encourage change and allow a more comprehensive response, but noted that targeting the marketing of these treatments might be the more politically palatable course of action.

I think a really good logical first step is if you're going to market this stuff, if you're going to offer these services, the information you're using to market the services has to be accurate.

Even as the paper was being published, Caulfield said Health Canada weighed in by stating stem cell therapies need its approval.

Basically, if youre an MD, and you're providing stem cell therapy, you need to get it approved, said Caulfield. In the paper, we said Health Canada has got to get more aggressive, and thankfully, we're starting to see some action in that space.

He said ultimately, however, responses from Canadas regulatory bodies are often triggered by complaints from the public.

I've actually spoken to regulators, and theyre not hearing complaints about people being injured by stem cell treatment, said Caulfield. Of course, just because something is safe, doesn't mean it's a good idea.

Not only have some of these treatments shown to have caused real harm while offering little more than hope, Caulfield said there is a financial exploitation element, all of which can only leave a black mark on the science.

The spread of clinics marketing these interventions may, over the long term, damage public trust in legitimate regenerative technologies, thus adversely impacting their future development, he said. It confuses what is an incredibly promising field.

The most perplexing element of the proliferation of these treatments is the involvement of medical professionals who should know better, Caulfield said.

The team went into the analysis with the hypothesis that alternative practitioners were the ones providing and marketing stem cell therapies. This was true, but Caulfield said they were surprised to find that an MD was often involved.

I've been in the room with these health providers, and you get the sense that many of them believe it works.

More:
Regulatory heft needed to curb false promises on stem cells, says health law expert - Folio - University of Alberta

Archives