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Archive for the ‘Skin Stem Cells’ Category

"I tried four natural face masks in one week. Here’s exactly what they did for my skin." – Mamamia

Also, I think we're all trying to be kinder to the environment with our lifestyle choices, and unlike most sheet masks on the market, it's made with100 per cent natural cotton fibres that will biodegrade six months after use. The packaging itself is recyclable too.

If you've ever watched one of those videos of a baby smiling with glee after they try chocolate for the first time, that was me with chemical exfoliation. Unlike scrubs which use psychical exfoliation to buff away at dead skin, chemical exfoliants like AHAs, glycolic acid and lactic acid dissolve dead skin and sebum which can cause breakouts and dull skin.

And when it comes to products which do just that, this cult-favouritemask is one of my personal picks.

Not only does it kind of smell, and look, like theinside of a pumpkin pie, the wonderful combo of glycolic acid, fruit stem cells, Vitamin C, Manuka honey andantioxidant-rich pumpkin puree works to give you the deliciously radiant skin you crave.

In terms of tingliness, there was less sensation than the CannaCell Glow Mask but the results were equally as impressive. My pores appeared tighter, and the texture of my skin felt smoother, brighter and just... better.

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"I tried four natural face masks in one week. Here's exactly what they did for my skin." - Mamamia

Experts from the Mayo clinic: Spots on the skin can indicate cancer of the blood – The Times Hub

Experts from the Mayo clinic warned that spots on the skin may signal a blood cancer. In connection with what experts suggest as soon as possible to go to the doctor when the symptom of.

Leukemia is a cancer primarily occurs in the bone marrow as a result of mutations in blood stem cell. The consequence is the loss of the descendants of the mutated cells ability to differentiate to Mature blood cells. The danger of the disease is that the symptoms are not specific, often among the signs unexplained weight loss, fever and chills. The experts considered it important to warn you that spots on the skin can indicate cancer of the blood that allows an early identification is a deadly health hazard. Among the other important symptoms of blood cancer: swollen lymph nodes, enlarged liver or spleen, frequent nosebleeds, excessive sweating, especially at night, bone pain, constant fatigue, recurrent infections.

With regard to treatment, the experts from Mayo clinic said: chemotherapy is the main form of treatment. Biological therapy works by using methods that help the immune system to recognize cancer cells and attack them. Among the methods of struggle with a deadly disease and radiation therapy, which destroys leukemia cells and stop their growth. Among the solutions and stem cell transplantation is bone marrow transplantation. The essence of the procedure is that the blood stream is filled with healthy blood cells, which often helps to restore normal functioning of the hematopoietic system.

Natasha Kumar is a general assignment reporter at the Times Hub. She has covered sports, entertainment and many other beats in her journalism career, and has lived in Manhattan for more than 8 years. Natasha has appeared periodically on national television shows and has been published in (among others) Hindustan Times.? Times of India

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Experts from the Mayo clinic: Spots on the skin can indicate cancer of the blood - The Times Hub

Cosmetic Skin Care Market Competitive Insights, Trends and Demand Growth 2019 to 2026 – Food & Beverage Herald

This Cosmetic Skin Care market report endows with a far-reaching survey of key players in the market which is based on a range of objectives of an organization such as profiling, the product outline, the quantity of production, required raw material, and the financial health of the organization. One of the sections in the report covers the evaluation of probabilities of the new investment projects and overall research conclusions are offered. Thus, the transparent, truthful and extensive market information and data included in this global industry report will definitely help develop business and improve return on investment (ROI).

Global cosmetic skin care market is set to witness a substantial CAGR of 5.5% in the forecast period of 2019- 2026. The report contains data of the base year 2018 and historic year 2017. Increasing self-consciousness among population and rising demand for anti- aging skin care products are the factor for the market growth.

Global Cosmetic Skin Care Market By Product (Anti-Aging Cosmetic Products, Skin Whitening Cosmetic Products, Sensitive Skin Care Products, Anti-Acne Products, Dry Skin Care Products, Warts Removal Products, Infant Skin Care Products, Anti-Scars Solution Products, Mole Removal Products, Multi Utility Products), Application (Flakiness Reduction, Stem Cells Protection against UV, Rehydrate the skins surface, Minimize wrinkles, Increase the viscosity of Aqueous, Others), Gender (Men, Women), Distribution Channel (Online, Departmental Stores and Convenience Stores, Pharmacies, Supermarket, Others), Geography (North America, Europe, Asia-Pacific, South America, Middle East and Africa) Industry Trends and Forecast to 2026 ;

Complete report on Global Cosmetic Skin Care Market Research Report 2019-2026 spread across 350 Pages, profiling Top companies and supports with tables and figures

Market Definition: Global Cosmetic Skin Care Market

Cosmetic skin care is a variety of products which are used to improve the skins appearance and alleviate skin conditions. It consists different products such as anti- aging cosmetic products, sensitive skin care products, anti- scar solution products, warts removal products, infant skin care products and other. They contain various ingredients which are beneficial for the skin such as phytochemicals, vitamins, essential oils, and other. Their main function is to make the skin healthy and repair the skin damages.

Key Questions Answered in Global Cosmetic Skin Care Market Report:-Our Report offers:-

Top Key Players:

Market Drivers:

Market Restraints:

Key Developments in the Market:

Customize report of Global Cosmetic Skin Care Market as per customers requirement also available.Market Segmentations:Global Cosmetic Skin Care Market is segmented on the basis of

Market Segmentations in Details:By Product

By Application

By Gender

By Distribution Channel

By GeographyNorth America



South America

Middle East & Africa

Competitive Analysis: Global Cosmetic Skin Care Market

Global cosmetic skin care market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of cosmetic skin care market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

About Data Bridge Market Research:Data Bridge Market Researchset forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

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Cosmetic Skin Care Market Competitive Insights, Trends and Demand Growth 2019 to 2026 - Food & Beverage Herald

From stylish clothes to indoor gardening, 9 tips and trends to try this winter – Commercial Appeal

Jean Chen Smith, Correspondent for Memphis Commercial Appeal Published 6:00 a.m. CT Jan. 10, 2020

During the first part of winter, the holidays can be all-consuming from shopping to stressing to spending time with friends and family.But there's so much more to the season than that.

Here are nine tips and trends to keep things fresh this winter:

With shorter days and busy schedules, it becomes more difficult to eat delicious and nutritious meals. Heres where Fresh n Lean comes in. This healthy and convenient service was conceptualized by founder Laureen Asseo while preparing meals for friends and family during a time when her father was facing serious health concerns. The meal delivery service provides specialized categories such as Keto, Paleo and Vegan using the highest quality organic ingredients without preservatives or added sugar.The cost is as low as $11 a meal, and menu choices include dishes such as Coconut Chicken Curry with Mixed Vegetables and Chile Lime Salmon with Broccoli.The dishes are never frozen and can be heated up in less than 3 minutes.


Bring the outdoors inside with the AeroGarden Harvest Elite Slim.(Photo: AeroGarden)

With the AeroGarden Harvest Elite ($125), you can grow an indoor garden of gourmet herbs, heirloom salad greens, red heirloom cherry tomatoes or cascading petunias. Easy to use and sleek with a premium brushed stainless-steel finish, the AeroGarden requires minimal care and can be set on vacation mode, all the while dressing up the kitchen countertop.


... Or maybe it never left. When more is required of you than the Casual Friday outfit, men will find the Treffort Contemporary Fit Signature Oxford Shirt ($165) is a wardrobe essential for any office.The mens shirts are made with premium 100% Egyptian and Turkish cotton, using organic colorants that boast unique patterns to create soft comfort with minimal creasing. The company strives for eco-friendly production without sacrificing quality.


The SOUVENIR Toulouse Top is inspired by world travel.(Photo: SOUVENIR)

The silk Moroccan-inspired Toulouse Top ($300) bySOUVENIR is a beautiful novelty printed silk top that is super versatile.It can be worn with a structured woven jacket for a business lunch, free flowing out to dinner or as a pullover on vacation.Based in Los Angeles, the brand is inspired by travel and world culture, with a focus on bright colors and fun prints.


Just because its cold outside and you need to bundle up doesnt mean you cant look good.For men, Obermeyers Down Snowshirt ($159) is the perfect remedy with itscasual, lightweight fabric and engineered quilting. Featuring certified 550 Fill Power Duck Down, snap placket, cuffs, chest and hand warmer pockets, it can be worn as a layering piece or as a casual top.


Orvis men's flannel provides casual warmth.(Photo: Orvis)

Orvis Mens Flat Creek Tech Flannel ($98) is comfortable and made from recycled oyster shells and PET polyester (think plastic bottles) to create an eco-blend that is then brushed to a soft hand.


Available for both men and women, Gobi Heats outerwear such as the Victoria Heated Puffer Coat and Sahara Mens Heated Jacket are wind- and water-resistant, keeping you warm and dry throughout the season.Stylish and comfortable, the jackets have an easy one-touch LED controller with three heat settings: low, medium and high.


Frances Austen cashmere Is the ultimate staple for your winter wardrobe.(Photo: Frances Austen)

Cashmere is one of the most precious and sought-after fibers because of its soft, silken feel.Frances Austenmakes the same heirloom-quality luxury cashmere that your grandmother owned, but at a more reasonable price point. The company partners with Scotland-basedJohnstons of Elgin, sweater manufacturer to big European fashion houses, and only releases two collections a year.The companys best-seller, Raw Edge Crew Neck(prices vary), is spun in Italy and perfectly matches with a pair of dress pants or jeans. It's also available in a colorblock version.


Lascanas Quilt Panel Moto Jacket ($89) is not only stylish and reasonably priced, it looks like the real deal while it is faux leather. With chic rose gold zippers and a flattering fit, this is a great item for any size and shape.


Cat lovers will rejoice at how easy it is to feed fresh, human-grade food to their furry friend with Smalls, which ships directly to your door. The company makes freeze-dried raw kibble and treats that are specifically tailored to fit your cats nutritional needs. You simply add warm water, mix and serve.Smalls believes in giving back and works with shelters and animal nonprofits across the United States to provide quality food to cats in need.With their Shelter Program, shelters can order Smalls in bulk at cost-pricing.


The new CannaCell line from Andalou Naturals is super-powered by antioxidants from hemp stem cells, which help to defend against free radicals and counteract premature aging due to oxidative damage, pollutionand UV sun exposure. Hemp stem cells and hemp seed oil provide the skin with nourishing proteins, nutrients and minerals so that the products penetrate the skin for optimal results.


Check out Revos 1985 sunglasses collection, which pays homage to the '80s with sixclassic unisex frame styles that not only look great but are also functional. Heralded as the leader in polarized lens technology, the brand was created using technology developed by NASA as solar protection for satellites.


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From stylish clothes to indoor gardening, 9 tips and trends to try this winter - Commercial Appeal

What will be the biggest scientific breakthrough of 2020? –

Cheap, re-purposed cancer drugs, negative carbon-emissions technology, calculating how fast the universe is expandingand huge leaps forward in quantum computing.

Will one of these be the biggest scientific breakthrough of 2020?

We asked a handful of New Zealand's top scientists what "Eureka!" moments might be on the cards next year but even with their formidable combined brain power and expertise, some found it hard to answer and hinted it was difficult to sheet home specific advances to any one year.

And, as one scientist says, 2020's most ground-breaking discovery may come as a total surprise, made accidentally by a student in a lab late one night.

READ MORE:*Scientists are baffled: What's up with the universe?*Medicine already in use may help cancer treatments*Roger Hanson: How you figure out the age of the universe*Doing my part not only to be carbon neutral but carbon negative


2020's most ground-breaking discovery may come as a total surprise, made accidentally by a student in a lab late one night.

Wellington's Gillies McIndoe Research Institute is carrying out cutting-edge research into ways of treating cancer without radiotherapy, chemotherapy or surgery.

The institute's founder and executive director, Dr Swee Tan, believes significant steps will be made in 2020 towards "re-purposing" existing drugs for cancer treatment.

Tan, a plastic surgeon and medical researcher who has received international recognition for dealing with life-threatening and disfiguring conditions, saiddrugs licensed and marketed for a particular treatment often had other benefits.

"They can be re-purposed for another condition, for the treatment of cancer. This is usually with drugs that have been around for some time they are off-patent, so they become generic, which means they cost next to nothing.

"Another advantage is their safety profile is well understood."

Wellington's Gillies McIndoe Research Institute's founder and executive director, Dr Swee Tan, believes significant steps will be made in 2020 towards "re-purposing" existing drugs for cancer treatment.

Globally, 18 million new cancer cases are diagnosed each year, resulting in nearly 10 million deaths.

"In New Zealand alone, new cancer cases are about 25,000 a year, and on top of that there are 11,000 non-melanoma skin cancers.

"The incidence of cancer is predicted to increase by 50 per cent by 2035, which is just around the corner. We are completely unprepared for that."

The increased incidence of cancer largely bowel, breast, prostate and lung cancers, and melanoma is mostly because people are living longer and due to lifestyle and diet, Tan says.

"Part of the problem now is the expense of treatment. In New Zealand, we spend $1 billion a year to treat cancer, and that is just the fiscal cost, that doesn't count emotional or personal.

"The cost is escalating because of the novel cancer drugsand, at some point, we are not going to be able to afford treatment for cancer.

"This creates disparity in access to treatment because some of these drugs are not funded and, if you have the means, you can buy it, but I don't think that is a good way to run a society. I think a society should allow people to access healthcare, regardless of personal circumstance."

Royal Society Te Aprangi/VIMEO

New Zealand is as vulnerable as all countries to the global growth in antimicrobial resistance that is making some diseases untreatable. Dr Siouxsie Wiles, a microbiologist from the University of Auckland, a Royal Society Te Aprangi Councillor and an expert adviser on the report on antimicrobial resistance produced by Royal Society Te Aprangi explains why it is such a big issue for us.

The institute has been undertaking a clinical trial based on drug re-purposing to control cancer stem cells, the proposed origin of cancer.

"It consists of a combination of low-cost, off-patent, oral medications to control cancer stem cells. We believe this would be more effective than using a single drug.

"For the cost of the drug itself, it costs about $4000 a year a patient, compared with the average cancer treatment, which is about $50,000 per patient.

"You have to prove it is effective first. The big issue with drug re-purposing is 'big pharma' is not interested because there is no money in it. The only way that we can realise the potential is for philanthropy and government to support initiatives like this."

Propranolol, a beta-blocker, had been added to the treatment for melanoma and angiosarcoma.

During 2020, GMRI would also be working on treatments for disfiguring keloid scars.

"They can cause quite significant issues with quality of life. They affect about 2 per cent of the general population, but in dark-skinned races, especially from the African continent, incidence can be up to 16 per cent.

"Treatment is really quite unsatisfactory, hence the reason why we are researching a solution. If you do surgery to remove it, almost every single one returns. Sometimes surgery is followed by radiotherapy to prevent recurrence. Topical chemotherapy is also used.

"What we have found is stem cells as the underlying problem. We are doing further work, which may allow us to develop a simpler, more effective, low-cost treatment taken by mouth, or by applying to the keloid lesion directly."

University of Auckland molecular biologist Dr Hilary Sheppard, a specialist in developmental and stem-cell biology, thinks there will be more emphasis next year on the gene-editing of adult cells.

University of Auckland microbiologist,associate professor Siouxsie Wiles, a specialist in infectious diseases and antimicrobial resistance, says there are "desperately" needed breakthroughs in her field next year and beyond, including:

- Rapid "bedside" diagnostic tests that are cheap and can tell the medical practitioner if the patient has a bacterial or viral infection "a bonus if it can tell, if bacterial, what antibiotics would kill the bacterium responsible".

- Effective vaccines for tuberculosis, gonorrhoea, Staphylococcus aureus, Group A and B Streptococci, giardia "I could go on and on".

- Drugs that can kill carbapenemase-producing Enterobacteriaceae "a very scary group of organisms that are becoming untreatable".

"The other breakthroughs we need aren't scientific, they are political," she says.

"[We need] a global agreement on tackling antimicrobial resistance, which would include incentives to bring the pharmaceutical industry back in to antimicrobial development.

"Failing that, nationalisation of pharmaceutical companies so that development of drugs isn't a for-profit initiative."

Phil Doyle/Stuff

University of Auckland microbiologist, associate professor Siouxsie Wiles, says a global agreement on tackling antimicrobial resistance is desperately needed.

University of Auckland molecular biologist Dr Hilary Sheppard, a specialist in developmental and stem-cell biology, thinks there will be more emphasis next year on the gene-editing of adult cells.

"We have seen some major breakthroughs this year, such as the versatile tool which allows for gene-editing with increased precision over existing tools so the technique is becoming more reliable and safer. Hopefully, next year, we will see these newer techniques being tested in clinically relevant cells.

"As part of that, I hope we will see a community-wide discussion about the ethics of gene-editing with a particular focus on adult cells. Personally, I do not think we should be editing germline cells or embryos at least not for the next five years, while the ethical issues are debated.

"Part of gene-editing is knowing what DNA sequence needs to be edited, so I think I hope this could be the year where personalised medicine and individual genotyping takes off.

"Our research focuses on patients with a fragile skin condition called epidermolysis bullosa (EB). We are pushing to get patients with EB genotyped so that we can perform gene-editing on their skin cells we can't do anything useful without this information.

"Currently, we are paying for the genotyping out of our research budgets. Of course, genotyping raises its own ethical and societal issues, so I hope we will see more discussion about this."

In 2020, results should start rolling in from clinical trials using edited T-cells against melanoma and edited bone-marrow cells to treat patients with sickle-cell anaemia, Sheppard says.

"These are very exciting times. I'm sure we'll see more clinical trials targeting previously untargeted disorders soon perhaps for conditions like Duchenne muscular dystrophy and cystic fibrosis."


In this podcast, The Detail's Sharon Brettkelly talks to Auckland University physics professor Shaun Hendy about his no-flying mission for the whole of last year.

While Tan, Sheppard and Wiles are looking for discoveries on the tiniest of scales, other scientists are grappling with the biggest question in the universe.

Theoretical cosmologist and University of Auckland professor of physics Richard Easther is among those hoping for a resolution of what has become known as "Hubble tension" a growing disagreement in calculations of how fast the universe is expanding, which has repercussions on its likely age.

The Hubble Constant the number that tells us how fast the universe was expanding has always been hard to measure, he says.

"There was a period of time when a whole different bunch of approaches to measuring it had converged on a single value, which is fascinating. But just over the last couple of years, it seems like there are now two different sets of numbers you get and they've pulled apart a little bit.

"You know, there's this joke that science isn't so much about people saying 'Eureka!' but about someone looking at something and going, 'well, you know, that's funny'.

"This is increasingly resembling one of those moments.

"The numbers are clustering around two values one that would put it in the early to mid-70s [kilometres per second per megaparsec], and one that would put it in the mid- to late 60s, and the uncertainty in the measurements is such that they don't really overlap with each other.

"As the individual measurements get more accurate, the sharpness of the disagreement is growing."

University of Auckland physicist, professor Shaun Hendy, is expecting leaps ahead in clean energy in 2020.

Does it matter? Of course, Easther says.

"There are different physical assumptions that go into the different measurementsandso, if there is a real discrepancy, it would tell us there's something about the expansion of the universe that we don't understand.

"It's hinting at that. The implication seems to be that the story is one step more complicated than current models of the expanding universe might recognise.

"One thought is, that in one set of numbers, there's something that got missed and kind of got away. The other possibility is, there's something kind of physical, that isn't included in our current thinking of the expanding universe.

"The idea that there is something interesting going on is something that cosmologists over the course of the last year have grown substantially more willing to entertain."

Chris Skelton/STUFF

Nicola Gaston is an Associate Professor in the Department of Physics at the University of Auckland and Co-Director of the MacDiarmid Institute for Advanced Materials and Nanotechnology.

At the University of Otago, associate professor Mikkel Andersen, a physicist in the university's Dodd-Walls Centre for Photonic and Quantum Technologies, has been making astounding international discoveries and controlling the movement of individual atoms in a world-first laboratory experiment.

Such control opens up possibilities for a "second quantum technology revolution" and quantum supremacy, something Andersen says will creep closer in 2020.

The first quantum revolution was made possible by the discovery of quantum mechanics in the 1920s, leading to the development of transistors and lasers, the building blocks of all computers.

In the second, he says quantum computers of fewer than 100 atoms will ultimately be able to out-compete "the world's combined conventional computing power".

"Reaching quantum supremacy means that a quantum computer will be able to do calculations that cannot be done on the world's conventional computers. I do not know if it will happen next year, but it will happen eventually.

"In recent years, Google, IBM, Microsoft and a lot of others have invested enormously in development of quantum computers. Quantum supremacy is likely still some years away, but it is one of those things that would clear all the headlines if it happened in 2020."

University of Auckland physicist,professor Shaun Hendy, agrees.

"Google declared quantum supremacy last month they demonstrated that a quantum computer could beat a conventional computer, albeit at a very niche task.

"We'll see more of this next year, as quantum computers start to stretch their legs just don't expect to see one on your phone any time soon."

Ross Giblin

Victoria University of Wellington's professor James Renwick hopes to see breakthroughs in climate change science which reduce greenhouse gas emissions.

Hendy is also expecting leaps ahead in clean energy in 2020.

"We will continue to see the cost of solar and battery technologies fall, to the extent that they will start to disrupt other energy systems. We have seen this already in Australia, where it has become a defining political issue.

"It will play out differently in New Zealand, because our grid is already more than 80 per cent renewable, while many of our industrial energy systems are not. Expect to see some of our big industrial corporates Fonterra, NZ Steel etc moving to greener industrial processes."

Victoria University of Wellington's Professor James Renwick, head of the school of geography, environment and earth sciences, hopes to see breakthroughs in climate change science which reduce greenhouse gas emissions.

He points to work being done at the Cawthron Institute in Nelson into the benefits of using the seaweed Asparagopsis armata as cattle feed. Chemicals in the red seaweed reduce microbes in the stomachs of cattle that make them burp when eating grass.

Renwick is also excited about the use of artificial intelligence (AI) and machine learning to help with severe weather prediction.

"Weather forecasters are totally inundated with information these days, volumes of radar data and satellite data coming through every 10 minutes. So, AI can help in making sense of all that, and what is the most important in determining where, for example, a severe storm will happen."

University of Otago associate professor Mikkel Andersen believes a "second quantum technology revolution" and quantum supremacy will creep closer in 2020.

Auckland University of Technology senior lecturer Dr Mahsa Mohaghegh also foresees huge steps forward in AI and its applications next year and beyond.

"In the medical sector, AI is being used to speed up symptom recognition and diagnosis. Early warning signs can be easily detected, allowing fast reaction.

"Environment and climate monitoring using AI can assist with weather-cycle predictions, frost warnings, and harvest alerts. Automated irrigation is possible using moisture and temperature sensors."

There are also uses in New Zealand's burgeoning space industry, in traffic management and in the "smart home" of the future, she says.

"New Zealand is a leader and frontrunner in the development of AI and related fields. The next 10 years of technology development are set to be exciting."

David White

Auckland University of Technology senior lecturer Dr Mahsa Mohaghegh foresees huge steps forward in AI and its applications next year.

University of Auckland physicist, associate professor Nicola Gaston, co-director of the Victoria University of Wellington-hosted MacDiarmid Institute for Advanced Materials and Nanotechnology, told Stuff scientific discovery did not happen "one year at a time".

"Discoveries that impact on our lives next year will be built on work that has been going on for decades. The biggest discoveries of next year will be the ones that impact on our lives in a decade or two.

"But there is no competition between this fundamental scientific work of discovery and the development of technologies. The two go in tandemand, perhaps in 2020, we can try to appreciate that."

That may be finding a way of moving to negative emissions technologies, or changing the chemistry of materials so they are recyclable and avoid environmental pollution.

"The most important breakthrough of 2020 will be one that none of us sees.

"It'll be a dedicated student or post-doc in a lab somewhere, or up late at night on a computer, who solves the last remaining piece of one of the puzzles that underpin so much of what we hope technology can do for us in the future."

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What will be the biggest scientific breakthrough of 2020? -

LEUKOTAC (inolimomab) is available again in France, following the granting of cohort ATU for the treatment of graft-versus-host disease,…

LEUKOTAC (inolimomab) is available again in France, following the granting of cohort ATU for the treatment of graft-versus-host disease, corticosteroid-resistant or corticosteroid-dependent, with grade II-IV

Lyon, FRANCE, January 9, 2020, ElsaLys Biotech announced today that the cATU has been granted by the ANSM and its clinical experts, after evaluation of a dossier containing data on the quality, safety and efficacy of the drug based on its administration in several hundred patients included in clinical trials or treatedvia named patient Temporary Authorization for Use (ATU nominative) until November 2015. This authorization includes the implementation of a reinforced monitoring (defined in the Protocol for Therapeutic Use) of the efficacy and safety data obtained in patients treated within the framework of this cATU. Inolimomab treatment can only be considered if the patient cannot be included in an ongoing clinical trial.

"We have data that support the benefit of inolimomab treatment in patients with acute corticosteroid-resistant or corticosteroid-dependent graft-versus-host disease (Grades II-IV in Glucksberg classification)," said Dr. David LIENS, Chief Medical Officer, ElsaLys Biotech. "We are delighted with this decision by the ANSM, which allows us to, once again, make inolimomab (1 mg/mL, solution for infusion) available to hematologists in the therapeutic emergency which is this pathology".

"While we continue to work on the filing of marketing authorization applications (MAA) in Europe and in the US, this ATU demonstrates the therapeutic value of inolimomab in the management of acute graft-versus-host disease (aGvHD). The ATU program in France allows patients, whose survival is at stake, to have access to a therapeutic solution before marketing in Europe, in close collaboration with the competent authority, the ANSM. The implementation of this cATU is effective immediately" said Dr. Christine GUILLEN, CEO and co-founder of ElsaLys Biotech.

Considering the potential emergency situation of the indication, it is recommended that hematology specialists anticipate the administrative procedures by contacting the ATU Cell (by Tel: 0800 08 90 81 - Fax: 01 56 59 05 60 or by e-mail: which is at their disposal for any further information or request for a Protocol for Therapeutic Use and collection of information.

About inolimomab (LEUKOTAC)

Inolimomab (LEUKOTAC) is an immunotherapy monoclonal antibody that targets the interleukin-2 receptor (IL-2), a chemical molecule named cytokine that contributes to the development and proliferation of some white blood cells including T-cells responsible for aGvHD. By linking specifically to the a chain of the receptor (CD25), inolimomab prevents IL-2 from binding on the surface of the donors over-active T-cells which blocks their multiplication.

The efficacy of inolimomab in aGvHD lies mainly in its specificity and its preferential affinity to the CD25 receptor found on the surface of T-lymphocytes.

About steroid-resistant aGvHD

Formerly called bone marrow transplant, Hematopoietic Stem Cell Transplantation (HSCT) is the last therapeutic option for patients with certain blood cancers or severe immunodeficiency. In practice, the treatment is designed to replace the diseased blood cells of the patient with the hematopoietic stem cells of a matching donor (allograft).

Once grafted, these stem cells will produce new healthy and functional blood cells, including white blood cells that will allow patients to bridge their immune deficiency or to eliminate surviving cancer cells.

If this technique has made considerable progress in 60 years, half of transplant recipients are still victims of complications: side effects of conditioning pretreatment (that aims to prevent transplant rejection), long-term susceptibility to infections and GvHD. In the latter case, the donors over-active T-cells turn against the patients tissues: mucous membranes, skin, gastro-intestinal tract, liver and lungs. The acute form appears just after the transplant, the chronic form occurring several months later (preceded or not by an aGvHD).

Affecting between 30 to 55% of patients, GvHD is the main complication of transplantation. To halt this autoimmune disease, physicians combine corticosteroids with other immunosuppressive agents. The fact remains that some 30 to 50% of aGvHD gradually become resistant or dependant to these first-line treatments. To date clinicians do not have any standard of treatment approved in Europe for these patients for whom there is a strong unmet medical need. Thus, in Europe, 4,000 children and adults die each year from their aGvHD.


ELSALYS BIOTECH is a clinical stage immuno-oncology company which designs and develops a new generation of therapeutic antibodies targeting tumors and their immune and/or vascular microenvironment.

To convert these novel targets into drug candidates, the Company is currently conducting 5 proprietary development programs including inolimomab (LEUKOTAC), an immunotherapy antibody that has recently demonstrated its clinical superiority in Phase 3 and that is closed to market approval in an orphan post-cancer disease with very poor prognosis: steroid-resistant acute Graft-versus-Host Disease.

Founded in 2013, ELSALYS BIOTECH is located in the heart of the European cluster LYON BIOPOLE. Its shareholders are TRANSGENE, SOFIMAC INNOVATION, joined in 2015 by IM EUROPE, a subsidiary of INSTITUT MERIEUX, and CREDIT AGRICOLE CREATION, and in 2018 by LABORATOIRES THEA.

Stay in touch with ElsaLys Biotech and receive directly our press releases by filling our contact form on

And follow us on Twitter: @ElsalysBiotech


ELSALYS BIOTECHDr. Christine GUILLENCEO and Co-founder+33 (0)4 37 28 73

PRESSEATCG PARTNERS Marie PUVIEUX (France) +33 (0)6 10 54 36 72Cline VOISIN (UK/US) +33 (0)6 62 12 53

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LEUKOTAC (inolimomab) is available again in France, following the granting of cohort ATU for the treatment of graft-versus-host disease,...

The Top Biotech Trends We’ll Be Watching in 2020 – Singularity Hub

Last year left us with this piece of bombshell news: He Jiankui, the mastermind behind the CRISPR babies scandal, has been sentenced to three years in prison for violating Chinese laws on scientific research and medical management. Two of his colleagues also face prison for genetically engineering human embryos that eventually became the worlds first CRISPRd babies.

The story isnt over: at least one other scientist is eagerly following Hes footsteps in creating gene-edited humans, although he stresses that he wont implant any engineered embryos until receiving regulatory approval.

Biotech stories are rarely this dramatic. But as gene editing tools and assisted reproductive technologies increase in safety and precision, were bound to see ever more mind-bending headlines. Add in a dose of deep learning for drug discovery and synthetic biology, and its fair to say were getting closer to reshaping biology from the ground upboth ourselves and other living creatures around us.

Here are two stories in biotech were keeping our eyes on. Although successes likely wont come to fruition this year (sorry), these futuristic projects may be closer to reality than you think.

The idea of human-animal chimeras immediately triggers ethical aversion, but the dream of engineering replacement human organs in other animals is gaining momentum.

There are two main ways to do this. The slightly less ethically-fraught idea is to grow a fleet of pigs with heavily CRISPRd organs to make them more human-like. It sounds crazy, but scientists have already successfully transplanted pig hearts into baboonsa stand-in for people with heart failurewith some recipients living up to 180 days before they were euthanized. Despite having foreign hearts, the baboons were healthy and acted like their normal buoyant selves post-op.

But for cross-species transplantation, or xenotransplants to work in humans, we need to deal with PERVsa group of nasty pig genes scattered across the porcine genome, remnants of ancient viral infections that can tag along and potentially infect unsuspecting human recipients.

Theres plenty of progress here too: back in 2017 scientists at eGenesis, a startup spun off from Dr. George Churchs lab, used CRISPR to make PERV-free pig cells that eventually became PERV-free piglets after cloning. Then last month, eGenesis reported the birth of Pig3.0, the worlds most CRISPRd animal to further increase organ compatibility. These PERV-free genetic wonders had three pig genes that stimulate immunorejection removed, and nine brand new human genes to make themin theorymore compatible with human physiology. When raised to adulthood, pig3.0 could reproduce and pass on their genetic edits.

Although only a first clinical propotype that needs further validation and refinement, eGenesis is hopeful. According to one (perhaps overzealous) estimate, the first pig-to-human xenotranplant clinical trial could come in just two years.

The more ethically-challenged idea is to grow human organs directly inside other animalsin other words, engineer human-animal hybrid embryos and bring them to term. This approach marries two ethically uncomfortable technologies, germline editing and hybrids, into one solution that has many wondering if these engineered animals may somehow receive a dose of humanness by accident during development. What if, for example, human donor cells end up migrating to the hybrid animals brain?

Nevertheless, this year scientists at the University of Tokyo are planning to grow human tissue in rodent and pig embryos and transplant those hybrids into surrogates for further development. For now, bringing the embryos to term is completely out of the question. But the line between humans and other animals will only be further blurred in 2020, and scientists have begun debating a new label, substantially human, for living organisms that are mainly human in characteristicsbut not completely so.

With over 800 gene therapy trials in the running and several in mature stages, well likely see a leap in new gene medicine approvals and growth in CAR-T spheres. For now, although transformative, the three approved gene therapies have had lackluster market results, spurring some to ponder whether companies may cut down on investment.

The research community, however, is going strong, with a curious bifurcating trend emerging. Let me explain.

Genetic medicine, a grab-bag term for treatments that directly change genes or their expression, is usually an off-the-shelf solution. Cell therapies, such as the blood cancer breakthrough CAR-T, are extremely personalized in that a patients own immune cells are genetically enhanced. But the true power of genetic medicine lies in its potential for hyper-personalization, especially when it comes to rare genetic disorders. In contrast, CAR-Ts broader success may eventually rely on its ability to become one-size-fits-all.

One example of hyper-tailored gene medicine success is the harrowing story of Mila, a six-year-old with Batten disease, a neurodegenerative genetic disorder that is always fatal and was previously untreatable. Thanks to remarkable efforts from multiple teams, however, in just over a year scientists developed a new experimental therapy tailored to her unique genetic mutation. Since receiving the drug, Milas condition improved significantly.

Milas case is a proof-of-concept of the power of N=1 genetic medicine. Its unclear whether other children also carry her particular mutationBatten has more than a dozen different variants, each stemming from different genetic miscodingor if anyone else would ever benefit from the treatment.

For now, monumental costs and other necessary resources make it impossible to pull off similar feats for a broader population. This is a shame, because inherited diseases rarely have a single genetic cause. But costs for genome mapping and DNA synthesis are rapidly declining. Were starting to better understand how mutations lead to varied disorders. And with multiple gene medicines, such as antisense oligonucleotides (ASOs) finally making a comeback after 40 years, its not hard to envision a new era of hyper-personalized genetic treatments, especially for rare diseases.

In contrast, the path forward for CAR-T is to strip its personalization. Both FDA-approved CAR-T therapies require doctors to collect a patients own immune T cells, preserved and shipped to a manufacturer, genetically engineered to boost their cancer-hunting abilities, and infused back into patients. Each cycle is a race against the cancer clock, requiring about three to four weeks to manufacture. Shipping and labor costs further drive up the treatments price tag to hundreds of thousands of dollars per treatment.

These considerable problems have pushed scientists to actively research off-the-shelf CAR-T therapies, which can be made from healthy donor cells in giant batches and cryopreserved. The main stumbling block is immunorejection: engineered cells from donors can cause life-threatening immune problems, or be completely eliminated by the cancer patients immune system and lose efficacy.

The good news? Promising results are coming soon. One idea is to use T cells from umbilical cord blood, which are less likely to generate an immune response. Another is to engineer T cells from induced pluripotent stem cells (iPSC)mature cells returned back to a young, stem-like state. A patients skin cells, for example, could be made into iPSCs that constantly renew themselves, and only pushed to develop into cancer-fighting T cells when needed.

Yet another idea is to use gene editing to delete proteins on T cells that can trigger an immune responsethe first clinical trials with this approach are already underway. With at least nine different off-the-shelf CAR-T in early human trials, well likely see movement in industrialized CAR-T this year.

Theres lots of other stories in biotech we here at Singularity Hub are watching. For example, the use of AI in drug discovery, after years of hype, may finally meet its reckoning. That is, can the technology actually speed up the arduous process of finding new drug targets or the design of new drugs?

Another potentially game-changing story is that of Biogens Alzheimers drug candidate, which reported contradicting results last year but was still submitted to the FDA. If approved, itll be the first drug to slow cognitive decline in a decade. And of course, theres always the potential for another mind-breaking technological leap (or stumble?) thats hard to predict.

In other words: we cant wait to bring you new stories from biotechs cutting edge in 2020.

Image Credit: Image by Konstantin Kolosov from Pixabay

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The Top Biotech Trends We'll Be Watching in 2020 - Singularity Hub

CLS Holdings dips over acquisition, sale – Proactive Investors UK

PLC () dipped 3% to 286.52p in mid-afternoon after announcing the acquisition of multi-let office space in Staines, Surrey, as well as the sale of a London building to a private developer.

TWENTY was bought for 19mln, is currently let to four tenants and has a vacancy of 23%, while Quayside Lodge in Fulham, London, was sold for the same amount.

TWENTY Kingston Road offers strong reversionary potential with a yield of 7% once fully let and the acquisition is in line with our opportunistic approach, chief executive Fredrik Widlund said in a release.

s () lost 2% to 227.01p after posting like-for-like sales including fuel fell 1.1% in the 15 weeks to 4 January, while total retail sales slipped 0.9%.

The LFL sales slip was slightly worse than analyst expectations which had predicted that sales in the period would be mostly flat.

The FTSE 100 grocer is another major name in the sector suffering sales declines over the so-called golden Christmas quarter.

PLC () gained 6% to 86.63p in early afternoon trades on the back of an acquisition from Cemex SAB de CV ADR ().

The AIM-listed construction materials company will snap up the UK arm and some operation of the Mexican company for 178mln in cash, debt-free.

It will add 170mln tonnes of mineral reserves and resources while adding to the development of Breedons national asphalt strategy and increasing footprint in areas where it is underrepresented.

() rose 7% to 0.41p after updating investors on the Bonya tungsten and copper deposit in Australia resource potential.

Thor is drilling to establish Bonya as a source of ore to extend the life of its nearby Molyhil project.

Latest holes to be drilled showed best results of a 23m intersection at a grade of 0.58% WO3 (tungsten) from the surface at White Violet and a 9m copper band at Samarkand.

Pharos Energy PLC (LON:PHAR) slipped 5% to 55p at lunchtime after informing investors that the 2020 dividend will be halved compared to the 2019 payment.

The oiler will issue 2.75p per share, a yield of 5% on yesterday's close of 58p, to focus on capital investment in the expanded portfolio.

Production in Egypt came as a disappointment as well, with 6mln barrels of oil per day (boe/d) as opposed to the 6.5mln boe/d guidance.

() lost 4% to 156.5p as the footwear retailer posted lower profits but managed to keep the final divi at 8p per share.

The AIM-listed firm attributed the decline to government imposed increases in its operating costs.

For the year ended 5 October, the company reported an underlying pre-tax profit of 9.8mln, down from 11.4mln in the prior year, while revenues edged up 0.9% to 1.62bn.

MPAC Group PLC () shares were trading 16% higher at 240p in late morning after upgrading full-year profit expectations for the second time in four months.

The company, which provides high speed packaging and automation services, attributed the continuing momentum to a strong Q4 order intake and accelerated project execution.

I am confident that we will be able to report an excellent financial performance for 2019 and improved outlook for 2020 which gives us confidence for the future progress of the business, chief executive Tony Steels said in a release.

()(NASDAQ:MTP) hiked 24% to 3.4 on the back of positive results from additional studies on its MTD201 cancer drug.

The analysis revealed the candidate can be delivered via an injection under the skin rather than into the muscle.

It is a key advantage paving the way for approval, while a pivotal study is planned for later in the first half with preparations already underway.

PLC () topped the losers list with a 21% stumble to 65.35p as the mineral resource estimate for its Asacha Gold Mine was reduced after further analysis.

As of 20 December, the asset is estimated to hold 312,558 ounces of gold, as opposed to 553,052 ounces a year before.

The AIM-listed miner is now undertaking a new drilling campaign to upgrade the resources, while formal guidance for the current year will be published shortly.

Travelex owner () was not doing much better with a 16% fall to 130p after updating on the Sodinokibi Windows ransomware attack.

The FTSE 250-listed firm was asked to pay US$6m (4.6m) to restore the customer data they claimed to have swiped from Travelexs systems, or else they would sell it on the dark web.

Finablr said there was no evidence that personal customer data has been encrypted and no evidence that any data has been exfiltrated, adding that Travelex has successfully contained the spread of the ransomware.

() lost 14% to 2.5p after announcing the process for listing on the Hong Kong Stock Exchange is taking longer than expected.

The AIM-listed engineering and technology solutions provider to the bioenergy sector said admission to trades will occur in the first half of 2020.

Management added trading in the second half of 2019 remained strong and is optimistic for the current period.

Asimilar Group PLC (LON:ASLR) jumped 25% higher to 40.66p in early morning trade on Wednesdayafter launching a placing at a premium to Tuesday's closing share price, hot on the heels of last months change of name from YOLO Leisure.

The AIM-listed big data and Internet of Things firm raised 6.8mln by placing 17mln new shares at a price of 40p each withexisting and new investors, a 15% premium to Tuesdays closing price of 33.8p.

Chairman John Taylor said in a release the proceeds will be used to pursue potentially bold and transformative investment options.

() was also onthe gainers list with a 5% push upwards to 247.9p after announcing full-year profit before tax will be comfortably ahead of market expectations.

The financial services provider and retailer mentioned strong trading during the Christmas period, when the jewellery segment recorded double-digit revenue growth.

The company noted that a high gold price boosted profits in the precious metals segment while its pawnbroking and foreign currency divisions continued to produce good results.

() also nudged higher, up 4% to 18.25p as it set up a joint venture with Korean firm Daewoong Pharmaceutical Co.

The firms will develop new cell and gene therapies using Avactas Affimer proteins which will specifically target the development of a new class of mesenchymal stem cells (MSCs), for the treatment of autoimmune and inflammatory diseases.

The AIM-listed company said its research and development costs for these targets will be fully covered by the joint venture which is funded by Daewoong.

() has confirmed that it has received a premium-priced takeover offer from (), and, it is now in advanced talks with the FTSE 100-listed miner. The offer is pitched at 5.5p per share, which is a 34.1% premium to yesterdays closing price of 4.1p. In a statement released after the market close on Tuesday, Siriuss management team said it would be prepared to recommend an offer at that price.

() (NASDAQ:MTP) has hailed the positive results from a study assessing the potential to deliver one of its drugs via an injection under the skin rather than into the muscle. MTD201, which is being developed to treat carcinoid cancer and the growth hormone condition acromegaly, was able to maintain the correct levels of plasma octreotide over six to eight weeks using this subcutaneous method, researchers found.

() has signed an exclusive agreement worth up to US$63mln for its iron deficiency treatment Feraccru to be sold in China. The deal with ASK Pharm (Beijing Aosaikang Pharmaceutical), covers China, Hong Kong, Macau and Taiwan and will involve an upfront payment of US$11.4mln and up to US$51.4mln in milestone and royalties. ASK Pharm will also pay for the marketing authorisation process and commercialising of Feraccru, which is branded as Accrufer in the US.

() has set up a joint venture to develop new cell and gene therapies using its Affimer proteins. The new JV with Daewoong Pharmaceutical Co will specifically target the development of a new class of mesenchymal stem cells (MSCs), multipotent cells where functions can include being agents for the treatment of autoimmune and inflammatory diseases.

() has signed a one-year exclusive evaluation agreement with Corteva Agriscience. The American giant, valued at US$21bn, wants to assess the potential of the UK biopesticides specialists encapsulation technology, focusing on formulations for seed treatments.

() said it has now completed the fundraising it announced on 30 September 2019, which in total raised approximately 412,000, with the final stage raising 150,360 via an issue of 2,148,000 new ordinary shares at a price of 7p each to Zark Capital Limited. Following the issue, Zark will hold 6,000,000 ordinary shares, representing 9.7% of ADMs issued share capital.

() is to trial its graphene-enhanced asphalt Gipave at Romes Fiumicino airport. Gipave will be tested for six months on the airports Alpha taxiway, which handles intercontinental aircraft such as Boeing 777s and Airbus A380s.

() said it has won two large contracts for delivery of Knowledge Capture, part of its information management suite of products, with a minimum combined contract value of 0.9mln over their minimum term. In a statement, the leading global big data technology company noted that the latest contract wins add to a growing list of multi-national clients for both the group's RAPid supply chain analytics and information management solutions, adding 200,000 to the company's annual recurring revenue.

() announced that it has delivered network services to more than 100 hospital and specialist care sites as part of a government contract with the NHS. AdEPT was contracted in 2018 to improve network and bandwidth capacity, to allow for financial savings and better access to clinical systems, after the previous connection managed by () was deemed obsolete.

Group PLC () has seen strong inflows of new money in the first three months of its current year. The sustainable investment specialist said funds under management rose 7% to 16.1bn in the quarter to December with 771mln of new funds and a 289mln gain from market movements.

() has sold its UK B2C business for 200,000 as part of its restructuring plans. In an announcement after the close on Tuesday, the online gaming platform operator said the B2C business was sold by administrators to Grace Media Limited, and the firm had now entered a B2B partnership with Grace Media to facilitate continued delivery of its B2C services to its white label partners, through which it will receive monthly royalties

() on Wednesday confirmed the receipt of US$6.7mln in oil payments from the Kurdistan Regional Government (KRG). In a statement, the Iraq-based crude producer reported that the partners in the Taq oil field were paid US$6.7mln gross for oil sales in August 2019, and, its 44% net share amounted to US$3.6mln.

() has released a statement informing investors that it has received notice of a potential claim against the company from a former energy advisor, Askell Limited. In a brief statement, the small cap oiler said: AAOG believes the Askell claim is without merit and the company intends to defend the claim vigorously.

() has announced the appointment of Oscar Marin Garcia as a non-executive director of the company with immediate effect. The group noted that Garcia has over 20 years' experience, specialising in retail business in the Extremadura region of Spain and managing family office investments, and is co-founder and CEO of Lider Aliment, SA, a 200mln sales family owned company. W resources pointed out that Garcia has a beneficial interest in 114,655,600 ordinary shares, representing approximately 1.8% of the companys share capital.

() said that, further to its announcement on 23 December 2019, the sale of its Malaysian business to AAA Management Science Academy PLT for a total cash consideration of MYR 400,000 (approximately 75,000), payable over a 13 month period, has duly completed. Sam Malafeh, CEO of Malvern, commented: "We are delighted to have completed this transaction, as we can now bring greater focus to growing our UK and Singapore operations."

() said it, has collaborated with BMW Group to integrate its FOVIO driver monitoring technology into the BMW i Interaction EASE. It noted that this integration will be featured at the CES 2020 technology show in Las Vegas at the BMW booth Tech East Outside Area. The firm noted that BMW i Interaction EASE leverages Seeing Machines' technology as a component of their innovative HMI (Human-Machine Interface) concept, visualized through a windshield projected Head-up Display (HUD). It added that Seeing Machines' SVP of Fleet and Human Factors, Dr Mike Lenn, will also be conducting daily presentations on BMW's CES booth from Wednesday through Friday.

() announced that it has terminated its broker services agreement with GMP . Shore Capital Stockbrokers Limited is now the company's sole broker and Strand Hanson Limited continues to act as the company's Nominated & Financial Adviser, the group said.

Bluebird Merchant Ventures () announced that its Annual General Meeting, held on 28 December 2019 in Jersey, all resolutions were duly passed.

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CLS Holdings dips over acquisition, sale - Proactive Investors UK

How These Practitioners Can Help with New Year, New You Goals – Milwaukee Magazine

This is a sponsored story

The start of a new year is the perfect time to prioritize self-care and set health and wellness goals, so make 2020 your happiest yet with a new, enhanced version of you. Use this guide to find the doctors, therapists and practitioners that can help you look and feel your best.

When diet and exercise just wont provide the results youre looking for, visit Skiin Anti-Aging Lounge. They offer the only procedure that builds muscle. EMSCULPT has been proven safe and effective by the most reputable scientific methods. The procedure induces strong muscle contractions with Hifem (high-intensity electromagnetic) technology not achievable through voluntary contractions. This builds muscle and creates a sculpted, toned physique. Other services like CoolSculpting and Exilis also help clients reshape their bodies through nonsurgical, noninvasive methods. Skiin is the first and only CoolSculpting advanced education center in the nation. Another first: Exilis is the first and only device to combine radio frequency and ultrasound to tighten skin through heating and cooling.

Your face is the first place to show signs of aging, but there is a way to take back those years. Dr. John Yousif has received several awards for his research in facial aging. He has been practicing plastic and cosmetic surgery for over 30 years and has even pioneered new techniques like the Gortex Midface Lift and the Hyoid Suspension Neck Lift. At both Sier Medi-Spa and Ascension in Mequon, he offers surgical and nonsurgical procedures to reverse the signs of aging. All of the types of facelifts offered are long-lasting and natural looking, leaving clients feeling like a younger version of themselves.

RELATED What Is Man & Woman Of The Year?

Aqua, under the direction of Dr. Christopher Hussussian, is a full-service salon, spa and med spa offering a wide range of services in a luxurious setting on Pewaukee Lake. Whether you are hoping to change the way you look or feel or both Aqua has a solution to enhance your skin and hair for both body and face. New services for the new year include hair restoration for both men and women using PRP (platelet-rich plasma) with biotin and a new weight-loss program using the HCG hormone. They also offer advanced laser hair removal, Clear Lift skin tightening, ThermiVa and CoolSculpting, a popular nonsurgical fat cell reduction with lasting results. A consultation can help you decide what services would work best to achieve a healthier, happier version of yourself.

Serving the Lake Country area, Dr. Tom Stamas is helping people put their best face forward, one smile at a time. He specializes in smile design, a full dental restoration and reconstruction for those suffering from tooth damage or loss, or for those looking to fix crooked, worn or yellowed teeth. During your personalized consultation, Stamas and his team will help you select which treatments will bring your smile to life. Dental treatments like bridges, dental implants, crowns and state-of-the-art diagnostic tools are all available to restore the health, function and appearance of your smile. Youll feel good about the natural-looking results, and your self-esteem will get a boost too.

What if you could use undesired fat from your belly to get rid of the bags under your eyes? Sounds too good to be true, right? Anew Skin and Wellness has a procedure that is done right in the office with long lasting results. The nano-fat transfer removes a small amount of fat with micro liposuction. That fat is harvested for re-injection to the appropriate areas of the face, neck, earlobes, hands and thighs. It can also be used to plump thin lips, smooth cellulite and scars and restore skin elasticity. The nano-fat transfer is safe, effective, economical and helps clients look their best. The in-office procedure provides long-lasting results because the bodys stem cells can turn the aging skin into new, rejuvenated skin. Its the natural way to tighten and smooth skin, allowing you to turn back the clock without a surgical face- or neck-lift.

RELATED Local Homebuilders Talk About the Hottest Design Trends in Milwaukee Right Now

Dr. Arvind Ahuja has provided neurosurgical and endovascular care in southeastern Wisconsin for more than 20 years for brain, spine, artery and peripheral nerve conditions. Whether patients come to Neurosurgery and Endovascular Associates for neck and/or arm pain, back and/or leg pain or headache, the first step is always diagnostic testing to determine the cause of the pain, rather than just treating the symptoms. Often through treatments like medication, steroid injections, physical therapies and if need be surgery, patients achieve improved functioning and long-term relief. Ahujas specialized training in the nervous system is incredibly effective in treating spinal conditions, and his treatments give patients the opportunity to live a happier and morefunctional life.

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How These Practitioners Can Help with New Year, New You Goals - Milwaukee Magazine

Highs and Lows of Stem Cell Therapies: Off- The-Shelf Solutions – P&T Community

NEW YORK, Jan. 7, 2020 /PRNewswire/ --

Report Includes: - An overview of recent advances in stem cell therapies and coverage of potential stem cells used for regenerative advanced therapies

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- Discussion on role of genomic and epigenomics manipulations in generating safe and effective treatment options - Identification of autologous and allogeneic cells and their usage in creating advanced therapy medical products (ATMPs) - Information on 3D cell culture and discussion on advances in gene editing and gene programming techniques such as CRIPSR/Cas9, TALEN, and ZINC fingers - Insights into commercial and regulatory landscape, and evaluation of challenges and opportunities for developing autologous and allogenic "off the shelf" solutions

Summary Stem cells are unique in their ability to divide and develop into different cell types that form tissues and organs in the body during development and growth.The stem cell's role is to repair impaired or depleted cells, tissues and organs in the body that are damaged by disease, injury, or normal wear and tear.

Stem cells are found in every organ, but are most abundant in bone marrow, where they help to restore the blood and immune system.

Stem cells may be derived from various sources, including - - Adult stem cells (ASCs): Derived from tissue after birth, these include bone marrow, brain, peripheral blood, skeletal muscle, skin, teeth, heat, gut, liver, ovarian epithelium and testis, as well as umbilical cord stem cells and blood. These cells are currently most widely used for cellbased therapies. Hematopoietic stem cells (HSCs), which are derived from bone marrow, can give rise to red blood cells, white blood cells and platelets, whereas mesenchymal stem cells (MSCs) are derived from the stroma and give rise to non-blood forming cells and tissues. - Human embryonic stem cells (hESCs): Derived from embryos, these include stems cell lines, aborted embryos or from miscarriages, unused in vitro fertilized embryos and cloned embryos. There are currently no clinically approved treatments for embryonic stem cells. - Inducible pluripotent stem cell (iPSCs): These are stem cells generated in the laboratory by reprogramming adult cells that have already differentiated into specific cells, such as liver cells. They are used either for research purposes (e.g., experimental medicine testing toxicity of new drugs) or are under research for potential future clinical use.

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Highs and Lows of Stem Cell Therapies: Off- The-Shelf Solutions - P&T Community

UF student chosen for the Marshall Scholarship, will pursue Masters degrees in United Kingdom – The Independent Florida Alligator

In high school Aaron Sandoval became obsessed with Deadpool, Marvels comic character who has accelerated healing and regenerative powers.

Sandoval has turned in his superhero cape for a lab coat in medicine by working with reparative methods for the human body. And now, hes received a national award that will allow him to do that.

Sandoval, a 21-year-old UF biology senior, was selected for the Marshall Scholarship, which gives students in the U.S. a chance to pursue their graduate studies in the United Kingdom, all expenses paid. He is the second Marshall scholar in UFs history, following Steven Robinette in 2009.

Sandoval was one of 46 students chosen out of over 1,000 applicants across the U.S.

The Marshall Scholarship Program was created in 1953 to thank the U.S. for helping the U.K. after World War II under the Marshall Plan, which was the U.S.s way of helping European economies after the devastation of the war, according to the programs website.

It still hasnt really sunk in yet, Sandoval said. Im happy to have won it.

Sandoval said in his two years at the University of Cambridge and Kings College London hell study biochemistry and focus on the transfer of stem cells from the lab to the patients so they can understand what cells are being used to help them.

Sandoval has collaborated with UF faculty members like Malcolm Maden, a professor in UFs Cancer and Genetics Research Institute. Sandoval and Maden worked in a lab with an African spiny mouse, to figure out how stem cells repair parts of the human body like skin tissue.

In 2012, Maden and his research team discovered the African spiny mouses ability to regenerate skin scar free. Maden wrote one of Sandovals letters of recommendation for his application for the scholarship.

Sandoval said if the mouses regeneration of skin cells could be translated to humans, then a humans wounds could completely heal rather than scar.

Sandoval didnt have the opportunity to do research in high school and wanted to learn more at the university level, so he decided to take Madens lab.

Maden said Sandovals uniqueness stems from his intelligence, drive and ability to interact with different kinds of people.

Hes behaved like a dynamic scientist, not like an undergrad, he said. Completely amazing, totally unique guy.

Sandoval said he feels fortunate to have won the award and to have so many people who helped him get to this point.

I couldnt have done it without the support of family, friends, mentors, he said. It took a whole village to win this thing.

Contact Emma McAvoy at[emailprotected]. Follow her on Twitter@EmmaMcAvoy1.

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UF student chosen for the Marshall Scholarship, will pursue Masters degrees in United Kingdom - The Independent Florida Alligator

The viral Augustinus Bader rich cream has completely changed my skin for the better – Yahoo Lifestyle

Welcome to Try Before You Buy, a monthly series where we talk about the pricey beauty products and in-office treatments that are getting major buzz and give our honest feedback. This month, our Senior Beauty & Fashion Editor, Pia Velasco, talks about theAugustinus Bader cream that has changed her skin.

As a beauty editor, Ive tried hundreds (and maybe even thousands) of skincare products since starting my career seven years ago. There have been creams that promise to give me skin as soft as babys bum, serums that pledge to erase all signs of dark spots, face masks that swear theyll make my skin so radiant that itll blind my enemiesand guess what, most of them fell through on their promises. As such, Ive become skeptical when a brand tells me that their product is life-changing and that there isnt anything like it on the market. So when I met Professor Augustinus Bader, the director of the Applied Stem Cell Biology and Cell Technology at the University of Leipzig in Germany, earlier this year and he and his team told me about his epigenetic skincare line that changes the skin to the point of altering DNA, I have to admit that I did mentally raise an eyebrow.

However, I had heard about epigenetic skincare before and was fascinated by the science behind it. Essentially, epigenetics refers to the naturally occurring biological modification process of the DNA thats influenced by the environment and lifestyle patterns. For example, if you have a healthy diet and exercise on the regular, your genetic coding will eventually change to be healthier, and youll be able to transfer those healthy genes onto your offspring. Epigenetic skincare is the same conceptif you train your skin cells to be healthy, your skins DNA will change. Needless to say,I was curious to try it, and when a fellow beauty editor friend told me that she stopped using all of her skincare products after trying the Augustinus Bader The Rich Cream, I went from being curious to being eager to try it.

A quick background on my skin. Ive always had acne-prone skin, and because of my medium skin tone, Im also very prone to hyperpigmentation. Most of the skincare products I use target my acne concerns, but I also go ham on texture-refining products in hopes that one day Ill achieve glass-like skin. Im used to looking at ingredients that target specific skincare concerns (salicylic acid for acne, retinol for anti-aging, vitamin C for brightening, etc.), and for the first time, I was using a product that claimed that it would address all my concerns at once. Because of the way epigenetic skincare works, instead of targeting just one skincare concern, the product tells skin cells to be healthy, which in turn helps skin be the best version of itself.I know it sounds too good to be true, and while it may not work for everybody, holy shit it worked wonders for me.

Courtesy of Augustinus Bader

I started testing out the cream the way I approach all my beauty testing, I did a test-drive on half my face. On the left side of my face, I continued to use the products that were already in my arsenal, and on the right side of my face, I used the Augustinus Bader cream and nothing else. After about two weeks I started seeing a shiftmy acne wasnt working up, my skin texture was a lot more smooth, and it just looked overall healthier. I quickly tossed my other products and switched over to using The Rich Creamevery day. After a while, my skin started balancing out and both looked and felt a whole lot better. Now, Im not saying this product is magicbut Im also not saying that its not.

Im currently testing a whole new array of skincare products for the upcoming HelloGiggles Beauty Crush Awards (stay tuned!), and so Ive had to sacrifice the left side of my face to test new products (I switch off between sides). As a result, my skin has started to shift back into its old ways, with a resurgence of blemishes, dark spots, and uneven texture as I test out new formulas. But the right side of my face is still in A+ condition.

Sure, this product is definitely on the pricier side, but its a product that I can say with full confidence that I would actually buy if I wasnt a beauty editor. (Full disclosure: I receive a lot of free products from beauty brands, and Ive only bought about a handful of products with my own money since working in the business.) For me, getting my ideal skin has always been a battle, and Im so happy to have finally found a product that works magic for me, which is why I was excited to learn that the brand recently launched a body cream as well.

Courtesy of Augustinus Bader

Its important to remember that body care requires skincare too, after all, we do have skin on our bodies. The Augustinus Bader body cream fulfills the basic requirement of moisturizing skin, but what makes this anti-aging body product stand out is that it uses its epigenetic technology to target and treat stretch marks and cellulite with continued use. Now, I havent used it long enough to speak to its long-term effects, but I can say that its fast-absorbing formula does make my skin feel baby soft and look way smoother than it did before. Also, Im typically very good about sharing my beauty products with others, but when my boyfriend asked if he could use this cream I may or may not have told him Id put a curse on his ancestors if he dared. Nothing gets in the way of me and my Augustinus Bader products.

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The viral Augustinus Bader rich cream has completely changed my skin for the better - Yahoo Lifestyle

Super Naturals: the high-tech natural beauty brands changing the face of modern skincare – Evening Standard

The latest lifestyle, fashion and travel trends

A high-end bio-beauty boom is in full bloom thanks to a host of revolutionary brands set on changing the face of modern skincare. These are the five to know...

Hailing from the Napa Valley, where founder April Gargiulo spent two years researching and developing her Holy Grail skincare products using the same meticulous approach her family took to their fine wine business, Vintners Daughter champions just two products that promise dramatic, multi-correctional results using some of the worlds most active organic and foraged botanicals. The original Active Botanical Serum (175) is hailed as the face oils to end all face oils and is built around the brands signature Phyto Radiance Infusion. This process starts with consciously grown whole plants such as calendula and super green alfalfa, known in ancient times as the foods of life, which undergo a methodical three-week long extraction to glean every last drop of their nutritional benefits. Just five drops using the brands 30-second Push/Press Method of application promises to deliver visible radiance, brightness and unparalleled nourishment particularly when used in conjunction with its preparatory Active Treatment Essence (210) (

The undisputed Queen of Green, Tata Harper is a pioneer of the farm-to-face beauty movement with all-natural formulations handcrafted in the brands laboratory in Vermont and bottles stamped with a code to trace how fresh your product is and who it was made by. The beauty editors favourite is going one step further with the launch of its Supernaturals 2.0 line of six products boasting 155 ultramodern green ingredients from 46 countries and of course, no synthetic chemicals. The Elixir Vitae Serum (391) alone boasts 34 new radical engineered ingredients from 25 countries, including kelp polymers from France developed to target cellular ageing. Other highlights from the range include the Concentrated Brightening Serum (257), which contains 24 ingredients to hydrate, 17 to reduce wrinkles, 15 to brighten and 13 to even skin tone, and the Boosted Contouring Serum (257), designed to lift, firm and restore youthful elasticity with a combination of Edelweiss stem cells and skin revitalising pomegranate. (

The brainchild of cosmetologist Anna Buonocore and naturalist Jeanette Thottrup, Seed To Skin believes that effective skincare is threefold. Firstly, that wild ingredients foraged from the land and sea used in conjunction with those sourced from its organic Tuscan farm are among the most potent nature has to offer. Secondly, that just like feeding your body skin requires a healthy, balanced diet and formulas that neither starve nor overload with any one element. Finally, that the most effective absorption relies on a precise mix of perfectly-sized molecules to ensure each ingredient is delivered exactly where it needs to go. As a result, its award-winning product line is loaded with game changers try The AlcheMist Super Active Serum Spray (145) to feed your skin a nutrient-rich drink whenever it needs a boost, or the Black Magic Detoxifying Oxygen Therapy Mask (119) which contains activated charcoal and volcanic clay for a one-stop facial in a jar (

(Wildsmith )

Inspired by the arboretums progressive approach to cultivation at Hampshires Heckfield Place and named after its mastermind William Walker Wildsmith, this ethical crafted-in-England skincare brand is designed for those who desire natural products but demand clinical results. Exclusive to Harrods beauty halls, the hero additions to its product line-up include the Platinum Booster (175) a powerful skin-firming treatment powered by encapsulated oxygen and moss cell cultures and a reviving, collagen-boosting Copper Peptide Cream and Serum Duo (150) which delivers a luminous finish to your complexion and comes in a compostable mycelium box (;

After turning to flower arranging as a weekly dose of mindfulness, beauty entrepreneur Kelly S Chung endeavoured to harness the healing power of nature or Flower Therapy, as she has coined it in another form; and Femmue was born. Fusing K-beauty innovation with a clean beauty ethos and the cellular energy of plants, the camellia flower is at the heart of the range and renowned for its antioxidant and restorative qualities. The Divine Camlia Facial Oil (100) is the purest form with 99.8 per cent camellia seed oil, while other must-try products in the line include the bestselling Flower Infused Fine Mask (40) formulated with camellia petals, geranium oil and cactus extract and the lavender-loaded Brilliant Cleansing Oil (73) (

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Super Naturals: the high-tech natural beauty brands changing the face of modern skincare - Evening Standard

22 Beauty Items From Amazon That Have Changed Our Editors’ Lives Their Reviews Prove It – POPSUGAR

Have you ever gone to look for something on Amazon and suddenly felt too overwhelmed by all the options? Yeah, me too. I love to have choices, but sometimes I need more information in order to make a smart buy. This is particularly true for beauty products the selection seems endless.

As a shopping editor, my sole job is to hunt for the best products customers should know about when it comes to beauty. I take that job very seriously, since we're literally using these items on our bodies. That's why I love trying new things from Amazon, because they often come with hundreds of customer reviews. I know it's a purchase I can feel good about after doing my research. I've rounded up the bestselling beauty products our editors have reviewed and bought themselves. Check out everything, and give something new a try.

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22 Beauty Items From Amazon That Have Changed Our Editors' Lives Their Reviews Prove It - POPSUGAR

Global Amniotic Membrane Market 2020-2024 | Evolving Opportunities with Celularity Inc. and Human Regenerative Technologies LLC | Technavio – Business…

LONDON--(BUSINESS WIRE)--Technavio has been monitoring the global amniotic membrane market since 2019 and the market is poised to grow by USD 1.48 billion during 2020-2024, progressing at a CAGR of more than 13% during the forecast period. Request a free sample report

Read the 145-page report with TOC on Amniotic Membrane Market Analysis Report by Geography (Asia, Europe, North America, and ROW), Type (Cryopreserved amniotic membrane and Dehydrated amniotic membrane), and the Segment Forecasts, 2020-2024.

The market is driven by the rising demand for biocompatible scaffolds. In addition, the rise in the development of new applications through research is anticipated to boost the growth of the amniotic membrane market.

The rising need for naturally derived materials in tissue scaffolding is increasing the demand for amniotic membranes. This is due to the specialized structure of amniotic membranes that exhibit high biological viability, making them ideal for creating bio-scaffolds. Moreover, the epithelial cells in amniotic membranes have the advantages of stem cells which provide a native environment of cell seeding. Bio-scaffolds are widely used in regenerative therapies for the treatment of bone, cartilage, skin, vascular tissues, and skeletal muscles. With growing geriatric population, the demand for such orthopaedic regenerative therapies is expected to increase significantly during the forecast period. This will have a positive impact on the demand for amniotic membranes.

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Major Five Amniotic Membrane Market Companies:

Celularity Inc.

Celularity Inc. operates its business through the Unified Business Segment. BIOVANCE is the key offering of the company. It offers a decellularized, dehydrated human amniotic membrane allograft that contains natural extracellular matrix (ECM) that helps in wound regeneration and tissue restoration.

Human Regenerative Technologies LLC

Human Regenerative Technologies LLC operates the business across segments such as Flowable and Membrane. HydraTek amniotic membrane products, is the key offering of the company. It includes thin and thick dehydrated amniotic membranes used in covering and protecting the recipient's tissue.

Integra LifeSciences Holdings Corp.

Integra LifeSciences Holdings Corp. operates its business across segments such as Codman Specialty Surgical, and Orthopedics and Tissue Technologies. The company offers a wide range of amniotic membrane products. Some of the key offerings include AmnioExcel Amniotic Allograft Membrane, BioDDryFlex Amniotic Tissue Membrane, BioDOptix Amniotic Extracellular Membrane, and Integra BioFix Amniotic Membrane Allograft.

Katena Products Inc.

Katena Products Inc. operates the business across segments such as Instruments, Biologics, Plugs, Lenses, Devices, and Blink Medical. Amniotic Membrane Surgical and Amniotic Membrane Clinic are some of the key offerings of the company.

MiMedx Group Inc.

MiMedx Group Inc. operates the business in the Regenerative biomaterial products and bioimplants segment. The company offers a wide range of amniotic membrane products. AmnioFix, EpiFix, and EpiBurn are the key offerings of the company.

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Amniotic Membrane Type Outlook (Revenue, USD Billion, 2020 - 2024)

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Related Reports on Healthcare include:

Global Extracorporeal Membrane Oxygenation Machines Market Global extracorporeal membrane oxygenation machines market by geography (Asia, Europe, North America, and ROW) and modality (veno-venous and arterio-venous; and veno-arterial).

Global Duchenne Muscular Dystrophy (DMD) Therapeutics Market Global Duchenne muscular dystrophy (DMD) therapeutics market by type (biologics and small molecules) and geography (Asia, Europe, North America, and ROW).

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Global Amniotic Membrane Market 2020-2024 | Evolving Opportunities with Celularity Inc. and Human Regenerative Technologies LLC | Technavio - Business...

The End of Infertility Is in Sight – UCSF News Services

Fertility expert Marcelle Cedars discusses the future of reproductive medicine.

By Ariel Bleicher UCSF Magazine

Advances in medicine and public health have dramatically extended the human lifespan. Our hearts, lungs, and other vital organs now last 79 years on average. For women, however, the ovaries which stop functioning at an average 51 years remain a stubborn exception. That may soon change, says fertility expert Marcelle Cedars, MD, during a conversation on the future of reproductive medicine.

There are two aspects. One is qualitative. As a woman ages, the quality of her eggs meaning their capacity to make a healthy baby declines. We understand very little about what causes this decline. If we understood that process better, we could dramatically impact fertility success rates.

The other aspect is quantitative. Women are born with a finite number of eggs, and they lose those eggs throughout their lifetime. In fact, that rapid decline in egg numbers starts even before birth. Theres a peak in utero of five to six million eggs. At birth, a woman has only about 1.5 million eggs; at the time of puberty, about 500,000. Through genetics research, were learning that the rate of this decline and the variability from woman to woman is largely driven by ones genes.

Exactly. But what if we could use your genetics and other biological data to understand your unique fertility risks and develop therapies specifically for you or for groups of women like you? This approach is called precision medicine. It has made a huge impact in the world of cancer in terms of improving survival rates. But in the field of reproductive health, precision medicine is still in its infancy.

Potentially. If we can pinpoint the mechanisms of ovarian aging, we could potentially develop a therapy that enables you to still have healthy eggs into your 50s, possibly your 60s. But just because we can do something doesnt always mean we should do it. We know that as women get older, pregnancies are more complicated. You have higher risk for things like high blood pressure, diabetes, and preterm labor. There are many downstream implications, both for the mothers health and the childs.

I dont think the goal should be to enable women to get pregnant into their 60s. Rather, we want women to have the best reproductive lifespan possible to be able to have children when they want to and to not have children when they don't want to and to have a society that supports women across that spectrum.

Were starting to believe that some of the same cellular mechanisms that underlie general aging might also control ovarian aging. This revelation makes the ovary even more interesting to study because its early demise could be a unique window into the bodys aging process. If we can identify cases of accelerated ovarian aging and understand the underlying causes, we might be able to improve not only reproductive function in individual women but also overall health and longevity for all women.

Samesex couples having genetically related children is probably on the horizon. Scientists are learning how to take skin cells or blood cells and turn them into stem cells, which can then be turned into eggs or sperm. Thats not science fiction; its already happening. We just need to figure out how to do it well and safely in humans.

Well probably also see germline engineering. Thats the process of editing genes in reproductive cells or embryos. It has the potential to cure disease before birth. This technology is here. But will society be ready to accept it? A lot of questions need to be answered before its put to use. In addition to technical hurdles, there are innumerable social issues. For instance, if we can eliminate a certain disease, will there be less focus on treatments for people who still have the disease? And what about access to care and social equity? Who would be able to afford these procedures? How will they be applied?

Restrictions are currently preventing the U.S. government from funding research that involves the manipulation of human embryos. As a result, funding for reproductive science is low, which has driven a lot of experts out of academia. If we want to see a revolution in reproductive health, like whats happening with precision cancer medicine, we need to invest in the development of scientific knowledge that will move this field forward.

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The End of Infertility Is in Sight - UCSF News Services

Why microneedling facials really work to revive 40+ skin –

I call it peak bleak: its right about now when all of us beyond our thirties are really thinking that our skin looks particularly knackered. Its central heating, its illness, its being overtired, over worked and over partied and it makes for a combination of low-level dryness and dullness that no illuminating make-up seems to ameliorate (highlighter on a dehydrated cheekbone is never flattering). Hydrating sheet masks, richer moisturisers and glycolic peels make some strides to improve exhausted skin, but the thing Ive found to make the single biggest difference is microneedling.

Im not referring to deep derma rolling treatments here (brilliant as they are for long term rejuvenation, they do entail some down-time) but rather facials - and at-home facial treatments - that incorporate a level of gentle needling. What gives these facials the edge on less than young skin is twofold: firstly, as leading facialist Sarah Chapman explains, microneedling is electronic precision engineering, creating thousands of needle columns into the skin, each one penetrating into the dermis layer to rejuvenate your skin by supercharging collagen production, which in turn reduces the appearance of wrinkles, fine lines and improves the overall texture of your skin. Which goes to say that it gets right to the root cause of a bleak complexion and directly revs it up.

Secondly, needling is astoundingly effective at aiding absorption of serums applied both during and after treatment (thanks to those tiny channels that Chapman described) and, quite frankly, the more hydrating serum you can get your skin to suck up, the better in terms of improving its plumpness and luminosity in both the short and long term.

Treatment wise, the best facial that incorporates needling is Chapmans Stem Cell Collagen Therapy treatment, 210. Chapman calls it the ultimate youth-boosting facial, a punchy claim that I must say its hard to dispute. The needling itself feels like nothing more than an electric toothbrush being whisked over the skin as it pushes in concentrated doses of botanical stem cells and peptides, while the finishing Dermalux red-light therapy adds to the impressive post-treatment glow. Whether you're looking for a facial that really delivers pre- or post-party, or simply want a fix to rid you of lacklustre skin, this is the facial to book.

At home, I like to needle every other day with a gentle manual 0.2-0.3mm roller: freshly rolled skin sucks in serum incredibly satisfyingly, and the increased microcirculation it induces adds to the don't you look well effect. Environs CIT Roller, 59, and Nannette de Gaspes Art of Noir Roller Noir, 35, both manage to be effective yet gentle. Do not be tempted to buy a cheap roller on Amazon or eBay; the needles are often hooked, which can rip the skin leading to redness and inflammation.

Roller Noir


Skinesis Intense Hydrating Booster


B-Hydra Intensive Hydration Serum


Peptide Veil


Rolling can be done on bare skin, but I find it more effective and comfortable to apply a thick layer of hydrating serum first, slathering on three times the amount Id usually apply of either Skinesis Intense Hydrating Booster, 64, or Drunk Elephant B-Hydra Intensive Hydrating Serum, 44. Start at the forehead and roll over each area three or four times horizontally, three or four times vertically, then diagonally in each direction, before moving onto the cheeks and finally chin and neck. Finish with a thick veil of cream (Im loving Decree Peptide Emollient Veil, 115) and youll wake up to skin that is anything but bleak.

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Why microneedling facials really work to revive 40+ skin -

The 20 Best New Beauty Products That’ll Help You Kick 2020 Off Right – InStyle

If your new year's resolutions includeorganizingthe skincare products taking over your medicine cabinet, checking the expiration dates on your makeup, and tossing those almostempty shampoo and conditioner bottles that have been taking up space in your shower since 2018, I've got some bad news for you:You're probably going to hit pause on reassessing your beauty routineuntil February.Thanks to January'snew beauty product launches, your collection is definitelygoing to grow this month.

Tatcha'sinnovative, travel-friendly serum stick will be the one skincare product you pack for every trip you take, while OLEHENRIKSEN'scleanseris like a refreshing fruit juice for your face. As for makeup, IT Cosmetics has created an uber-comfortable matte lipstick, and Hourglass' concealer is a long-wear formula that doesnotcrease.

Get exclusive discounts, celeb inspo, & more.

RELATED:All the Products Our Beauty Editors Loved Using in December

When it comes to haircare, the drugstore is the place to be. Celebrity hairstylist Kristin Ess has added fragrance-free products to her affordable namesake haircare line, and Pantenejust expanded its Gold Series Collection for natural hair with a hydrating, protective cream specifically formulated for braided styles.

While thesenew haircare, skincare, and makeup products are exciting, there's no question that having so many options can be overwhelming. That's why we've done the work topickout the top 20 worth spending your hard-earned coin on.

VIDEO:What Every Beginner Needs to Have in Their Makeup Kit

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The 20 Best New Beauty Products That'll Help You Kick 2020 Off Right - InStyle

Want to Rev up Your Immunity And Improve Skin Health? Consume Carrot Ginger Juice –

Being jam-packed with various essential nutrients like folate, Vitamin A, beta carotene, etc., carrot and ginger can offer you both health and beauty benefits. These kitchen companions can help diabetics to control their blood sugar level and have many more medicinal uses. These vegetables are known to treat ailments like cough and cold, nausea, anxiety, etc. From strengthening your immune system to protecting your against cancer and boosting collagen production, carrot ginger juice can do it all for you. Below, we give you more than one reason to add this juice to your daily diet.

Being a rich source of vitamin A, carrot ginger juice helps in strengthening your immune response. This nutrient is required to form white blood cells in the bone marrow stem cells. Notably, WBC is a significant component of your bodys defence system. So, it is advised to drink this juice on a daily basis. You can add oranges in the juice to make it a bit tasty.

For a healthy skin texture and tone, vitamin C and E are needed. Carrot ginger juice is a rich source of both nutrients. Your skin requires collagen for better elasticity, texture, and strength. Vitamin C helps in the synthesis of this protein and holds the body together. Even if you have a skin wound, you can have this drink and get rid of the problem soon. On the other hand, vitamin E protects your skin from the harmful effects of UV rays.

Carrot ginger juice is a detox drink that is jam-packed with vitamin C, a nutrient that is already linked to providing protection against cancer. The juice contains a compound called gingerol, that can potentially reduce your risk of developing breast, ovarian, and stomach cancers. This is what research published in the European Journal of Pharmacology reveals.

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Want to Rev up Your Immunity And Improve Skin Health? Consume Carrot Ginger Juice -

Making Blood On Demand: How Far Have We Come? – Eurasia Review

The reconstitution of the blood system in humans holds great therapeutic potential to treat many disorders, like blood cancers, sickle-cell anemia and others. Successful reconstitution requires the transplantation and engraftment of hematopoietic (or blood) stem cells (HSCs), which after reaching their niche, start producing all types of blood cells, including platelets, white and red blood cells.

In current clinical practice, this is carried out by infusing HSCs obtained from a matched donor who is immunologically compatible with the patient in need (allogeneic transplantation), or by the expansion of the patients own HSCs in the lab, and then re-infusing them back into the patient (ex-vivo, autologous transplantation).

However, the utility of both routes is currently limited by a number of factors. First, in the case of allogeneic transplantation, the scarcity of matched donors significantly increases the waiting time, which could be detrimental to the patient. Second, the ex vivo expansion of HSCs, whether allogeneic or autologous, has been a challenging task, due to the limited proliferative potential these cells exhibit in culture. These limitations have raised the need for other sources of HSCs that would alleviate the need for matched donors and yield functional HSCs in large quantities.

In 2007, Professor Shinya Yamanaka and colleagues demonstrated that somatic cells, like skin fibroblasts, could be reprogrammed back to a cellular state that resembled human embryonic stem cells (hESCs), which are a group of cells found in the blastocyst-stage human embryo and contribute solely to the development of the human fetus during pregnancy. The reprogrammed cells were termed, Induced Pluripotent Stem Cells (iPSCs).

In addition to their developmental potential, human ESCs and iPS cells display unlimited proliferative potential in culture, which makes them an ideal source of cells for regenerative medicine in general and for hematopoietic differentiation to obtain possibly unlimited quantities of HSCs. Therefore, there has been a growing interest to harness the potential of these cells for treating blood disorders.

However, advancement in deriving functional HSCs from human pluripotent stem cells has been slow. This has been attributed to incomplete understanding of the molecular mechanisms underlying normal hematopoiesis. In this review, the authors discuss the latest efforts to generate HSCs capable of long-term engraftment and reconstitution of the blood system from human pluripotent stem cells. Stem cell research has witnessed milestone achievements in this area in the last couple of years, the significance of which are discussed and analyzed in detail.

The authors additionally discuss two highly important families of transcription factors in the context of hematopoiesis and hematopoietic differentiation, the Homeobox (HOX) and GATA proteins. These are thought of as master regulators, in the sense of having numerous transcriptional targets, which upon activation, could elicit significant changes in cell identity. The authors hypothesize that precise temporal control of the levels of certain members of these families during hematopoietic differentiation could yield functional HSCs capable of long-term engraftment.

The authors conclude the review with a summary of future perspectives, in which they discuss how newly developed techniques, like the deactivated-Cas9 (dCas9) gene-expression control system, can be utilized during the course of hematopoietic differentiation of pluripotent stem cells for precise temporal control of the aforementioned master regulators to achieve functional HSCs.

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Making Blood On Demand: How Far Have We Come? - Eurasia Review

Victoria Beckham Dreams That her Beauty Line Will Become ‘Brand of the Future’ – Al Bawaba

Victoria Beckham aims to "create a brand of the future" with Victoria Beckham Beauty.

The former Spice Girl launched her eponymous beauty brand last year, later expanding her label to include skincare, and the 45-year-old fashion designer says her intention was to create products that are sustainable and not made from toxic formulas, whilst being "inclusive" for all skin tones.

The mother-of-four told the February issue of Harper's Bazaar UK: "I've been obsessed with make-up and skincare and wellness for longer than I can remember."But I couldn't find what I wanted - clean beauty.

"What is that, even? It's a real grey area.

"I wanted to create a brand of the future - focusing on what's in the formulas but then also sustainability.

"The other thing that was key was making sure it was very inclusive - whether it's make-up or skincare, this is for every skin type and tone, and for both women and men."

In November, Victoria - who has Brooklyn, 20, Romeo, 17, Cruz, 14 and Harper, eight, with retired soccer star husband David Beckham - released her Cell Rejuvenating Priming Moisturiser in collaboration with Professor Augustinus Bader, the German stem-cell scientist behind The Cream, which was named as one of 2019's most popular skincare products.

Bader's product features a patented Trigger Factor Complex that works to jumpstart your skin's repair and renewal functions to heal skin faster and in turn, improve the appearance of fine lines and wrinkles, and as a fan of the cream herself, Victoria was thrilled to work with the scientist.

She said: "It's been a dream to develop, with Augustinus, a priming moisturiser that works to improve the health of my skin and gives me that fresh, natural glow that I love."

The priming moisturiser is a hybrid product that combines primer with moisturiser, and is inspired by Victoria's own skincare routine.

Victoria's product implements Bader's Trigger Factor Complex technology, as well as the lipids, vitamins, and amino acids found in his original cream, but with the added benefit of also smoothing skin so it's prepped for make-up application.

Bader explained: "It's the first priming moisturiser of its kind to care for your skin cells while also preparing your skin for makeup application."

The cream has a lightweight texture that can be work alone to give skin a radiant finish or under make-up, which according to Victoria, "will enhance your products."

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Victoria Beckham Dreams That her Beauty Line Will Become 'Brand of the Future' - Al Bawaba

What are the odds? Stem cell recipient learns her donor is also in Ottawa – Ottawa Citizen

Colleen LeCours lay in a hospital bed at the General campus of The Ottawa Hospital on August 12, 2016, waiting for the only thing that could save her life a stem cell transplant from a stranger.

The donor could be anywhere in the world if a related blood donor cant be found, the call to find a match goes out to registries all over the globe and the donated stem cells are rushed across international borders.

What LeCours didnt know is that her donor, an 18-year-old Carleton University student named Timothy White, was just one floor below. Similarly, White didnt know that his recipient was in the same hospital.

There are currently more than 450,000 people on the Canadian Blood Services Stem Cell Registry formerly known as OneMatch and 36 million on affiliated international registries. Still, some people never find a match. There are more than 900 Canadians in need of a transplant who have not found a match anywhere in the world.

What were the odds that the match for LeCours, now 57, would be found in the same city?

Astronomical, she said.

The chances that White would even ever be asked to donate were also very low only about one in a thousand. After he agreed to donate, he was not told where the recipient might be. I was told the recipient could be anywhere. They could be in Africa, said White, now 22 and a recent graduate in computer science.

White had signed up for the registry through a cheek swab booth at ComiCon less than six months earlier. A smart place to recruit would-be stem cell donors, he notes. The optimal donor is a male between the age of 17 and 35 and thats the ComiCon demographic.

He decided to register as a potential donor because he grew up in the scouting movement. One of the main philosophies is to do a good turn every day, he said.

The donation was a non-surgical procedure in which Whites blood was removed though a needle, the stem cells were separated from his blood and the remaining blood components returned to his body through another needle. The procedure started at about 8 a.m. and was over by about 5 p.m.

I figured if I gave someone a day for a thousand more days (of life) then I felt it was a fair trade. I have many years of life. Why not spend one day? said White.

LeCourss medical journey started in 2009 with an emergency room visit for abdominal pain. She was eventually diagnosed with Stage 4 follicular lymphoma, a blood cancer that affects infection-fighting white blood cells. At the time, LeCours was working for Gov.-Gen. Michalle Jean and was able to stay on the job most of the time during her six months of treatment.

Four years later, the lymphoma returned. It was back again two years after that, in a more aggressive form. The only treatment was stem cell transplant.

There are two main kinds of stem cell transplants autologous and allogenic. In an autologous transplant, stem cells are collected from a patients own blood and reintroduced after being treated to remove cancer cells. In an allogenic stem cell transplant, the stem cells come from a donor.

At this point, LeCours was a candidate for an autologous transplant. Once again, she underwent aggressive chemotherapy. A year later, the cancer returned.

Doctors told LeCours there wasnt much else they could do and advised her to get her affairs in order. But the hospitals transplant team felt she could be a candidate for an allogenic transplant. Theres risk rejecting donated stem cells can be fatal to the patient.

LeCours learned that her brother was a match. But the medical work-up would last about three months and she couldnt wait that long.

I wasnt sure I wanted to do it but I didnt have much choice, she said. They said, We have someone waiting in the wings.

And I said, He probably has wings.

After the transplant, LeCours recovered as an outpatient in the home of her brother and sister-in-law. It took three months to rebuild her immune system. Her only rejection symptoms were a bit of skin irritation.

In January 2018, LeCours received an email asking if she would like to exchange contact information with her donor. She replied that she would.

A few months later, she got a message with Whites co-ordinates and was astonished to find that her donor was in Ottawa. It took her a few weeks to formulate an email.

I didnt want to scare him. I just wanted him to know how incredibly grateful I was. And I wanted to pay it forward, said LeCours.

After careful consideration, she sent White an email on Oct. 8, 2018.

Today, being Thanksgiving, I have so much to be thankful for, namely you giving your stem cells and saving my life and the success of the stem cells grafting to my bone marrow, LeCours wrote. I cant thank you enough for your wonderful selfless act.

Stem cell donor 18-year-old Carleton University student Timothy White at The Ottawa Hospital, General campus, donating stem cells for Colleen LeCours in August 2016. At the time he did not know that LeCours would be the recipient. Courtesy Timothy White.jpg

She added that she didnt know anything about him except for his name and email address, and asked if they could meet. They got together for the first time over lunch in a burger restaurant.

As soon as I saw him, I broke down, said LeCours.

It has been three and a half years since the transplant and LeCours remains in remission. She invited White to her familys Thanksgiving this year, and the two meet to catch up every few months. Its one of the quirks of stem cell donation that the recipient assumes the blood type of the donor. LeCours, once O-positive, now has blood type A-negative, like White.

Im a grandmother. The fact that my grandson has his moma is huge.


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What are the odds? Stem cell recipient learns her donor is also in Ottawa - Ottawa Citizen

Firm adds a new wrinkle to anti-aging products – Williamson Daily News

HUNTINGTON Serucell Corporation, a cosmeceutical company based in Huntington, has developed the worlds only dual-cell technology to create and produce anti-aging skincare products, and they did it in Huntington.

Serucell KFS Cellular Protein Complex Serum is made start to finish at Serucells laboratory on the south side of Huntington.

This has been one of the best kept secrets in West Virginia, said Cortland Bohacek, executive chairman and a co-founder of Serucell Corporation.

The company soft launch was in September 2018 at The Greenbrier Spas. The Official online launch was April 2019 and is getting exposure with some well known sellers like Neiman Marcus, local dermatologist and plastic surgeons offices and several other retail locations from New York to California. It is also sold online at

One person that has tried the product is Jennifer Wheeler, who is also a Huntington City Council member.

As a consumer I have an appreciation of the quality of the product and the results Ive seen using it, she said. It has been transformative for my skin and seems like its success will be transformative for our city as well.

She said Serucell and the people behind it are impressive on every level.

In my role on council, Im especially grateful for the companys conscious effort to stay and grow in our city, Wheeler said.

A one-ounce bottle of the serum costs $225. The recommended usage is twice per day and it will last on average of about six weeks.

Serucells active ingredient is called KFS (Keratinocyte Fibroblast Serum), which is made up of more than 1,500 naturally derived super proteins, collagens, peptides and signaling factors that support optimal communication within the cellular makeup of your skin.

This is the first and only dual-cell technology that optimizes hydration and harnesses the power of both keratinocytes and fibroblasts, two essential contributors to maintaining healthy skin by supporting natural rejuvenation of aging skin from the inside out, said Jennifer Hessel, president and CEO of the company.

When applied to the skin, KFS helps boost the skins natural ability to support new collagen and elastin, strengthen the connection and layer of support between the upper and lower layers of your skin. The result, over time is firmer, plumper and smoother skin, according to Hessel.

Why it works so naturally with your skin is because it is natural, Hessel said. These proteins play an important role in strengthening the bond between the layers of your skin, and thats where the re-boot happens.

KFS is the creation of Dr. Walter Neto, Serucells chief science officer and co-founder of the company. Neto is both a physician and a research scientist, specializing in the field of regenerative medicine with an emphasis on skin healing and repair.

Neto said Serucells technology unlocks the key to how our cells communicate and harnesses the signaling power actions to produce the thousands of bioactive proteins necessary to support the skins natural rejuvenation.

Originally from Brazil, Neto studied at Saint Matthews University and completed his clinical training in England. His clinical research on stem-cell cancer therapies, bone and tissue engineering and wound and burn healing led to his discovery in cell-to-cell communication, and ultimately the creation of Serucells KFS Cellular Protein Complex Serum.

Neto received multiple patents for the production method of Serucell KFS Serum. He lives in Huntington with his wife and four golden retrievers and works alongside his longtime friend, Dr. Brett Jarrell.

I have known Brett since I was 18 years old, Neto said.

Jarrell practices emergency medicine in Ashland, Kentucky, and oversees all aspects of quality control for Serucell. He received his bachelors degree in biology from Wittenberg University, his masters degree in biology from Marshall University and his medical degree from the Marshall University School of Medicine. Jarrell completed his residency at West Virginia University and is board certified by the American Board of Emergency Medicine.

Jarrell has served as a clinical instructor of emergency medicine at the Marshall School of Medicine, president of the West Virginia chapter of the American College of Emergency Medicine and he has published a number of peer-reviewed journal articles on stroke research.

Jarrell also lives in Huntington.

Another co-founder of the company is Dr. Tom McClellan.

McClellan is Serucells chief medical officer and director of research and is a well-respected plastic and reconstructive surgeon with a private practice, McClellan Plastic Surgery, in Morgantown.

McClellan completed his plastic and reconstructive surgery training at the world-renowned Lahey Clinic Foundation, a Harvard Medical School and Tufts Medical School affiliate in Boston, Massachusetts. While in Boston, he worked at Lahey Medical Center, Brigham and Womens Hospital, as well as at the Boston Childrens Hospital. McClellan is board certified by the American Board of Plastic Surgery.

In addition to his practice and role at Serucell, McClellan utilizes his surgical skills through pro bono work with InterplastWV, a non-profit group that provides comprehensive reconstructive surgery to the developing world. He has participated in surgical missions to Haiti, Peru and the Bahamas.

McClellan lives in Morgantown with his family.

All three doctors here have strong connections to West Virginia, and we didnt want to leave, Neto said. We all want to give back to West Virginia, so that is the main reason we have our business here in Huntington.

We are building a company we believe can make a difference in the community, Hessel added. Our goal is to grow Serucell and build our brand right here in Huntington. There is a pool of untapped talent here in Huntington. When we expand our business here, we can provide another reason for young people to be able to stay and grow their careers, whether it is in science, operations or manufacturing. The team is a pretty excited to make an impact in the community where it all started.

Hessel decline to give sales numbers, but said the business has been growing each year since the product was introduced. She also declined to give the number of employees at the facility, but did say it has sales representatives across the country.

Firm adds a new wrinkle to anti-aging products - Williamson Daily News

Victoria Beckham wants her beauty line to be ‘brand of the future’ –

3 January 2020

Victoria Beckham aims to "create a brand of the future" with Victoria Beckham Beauty.

Victoria Beckham

The former Spice Girl launched her eponymous beauty brand last year, later expanding her label to include skincare, and the 45-year-old fashion designer says her intention was to create products that are sustainable and not made from toxic formulas, whilst being "inclusive" for all skin tones.

The mother-of-four told the February issue of Harper's Bazaar UK: "I've been obsessed with make-up and skincare and wellness for longer than I can remember.

"But I couldn't find what I wanted - clean beauty.

"What is that, even? It's a real grey area.

"I wanted to create a brand of the future - focusing on what's in the formulas but then also sustainability.

"The other thing that was key was making sure it was very inclusive - whether it's make-up or skincare, this is for every skin type and tone, and for both women and men."

In November, Victoria - who has Brooklyn, 20, Romeo, 17, Cruz, 14 and Harper, eight, with retired soccer star husband David Beckham - released her Cell Rejuvenating Priming Moisturiser in collaboration with Professor Augustinus Bader, the German stem-cell scientist behind The Cream, which was named as one of 2019's most popular skincare products.

Bader's product features a patented Trigger Factor Complex that works to jumpstart your skin's repair and renewal functions to heal skin faster and in turn, improve the appearance of fine lines and wrinkles, and as a fan of the cream herself, Victoria was thrilled to work with the scientist.

She said: "It's been a dream to develop, with Augustinus, a priming moisturiser that works to improve the health of my skin and gives me that fresh, natural glow that I love."

The priming moisturiser is a hybrid product that combines primer with moisturiser, and is inspired by Victoria's own skincare routine.

Victoria's product implements Bader's Trigger Factor Complex technology, as well as the lipids, vitamins, and amino acids found in his original cream, but with the added benefit of also smoothing skin so it's prepped for make-up application.

Bader explained: "It's the first priming moisturiser of its kind to care for your skin cells while also preparing your skin for makeup application."

The cream has a lightweight texture that can be work alone to give skin a radiant finish or under make-up, which according to Victoria, "will enhance your products."

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Victoria Beckham wants her beauty line to be 'brand of the future' -

The Mutuality Between Mothers and Their Developing Babies – Patheos

Medical science is learning more and more about pregnancy and fetal development. And what they are finding is mind-blowing. We now know that there is a radical mutuality in the relationship between the mother and her child in the womb. Both work together to build the placenta. And just as cells from the mothers body become part of the baby, cells from the baby become permanent parts of the mother.

From an interview in the Catholic magazine Crux with Prof. Kristin Marguerite Collier of the University of Michigan Medical School:

The placenta is the organ through which the mother and prenatal child interface. The placenta is an organ that is attached to the inside of the uterus and connects to the prenatal child through the childs umbilical cord.

What is not as well known about this organ is that the placenta is the only organ in human biology that is made by two persons, together, in cooperation. The placenta is built from tissue that is part from mom, and part from the growing baby. Because of this, the placenta is referred to as a feto-maternal organ. It is the only organ made by two people, in cooperation with providence. It is the first time mom and her baby come together, albeit at the cellular level, to do something in cooperation. . . .

In the creation of the placenta, cells from the trophoblast, which are from the embryo, reach down towards the mothers uterine wall while at the same time, the spiral arteries from the mothers uterus are reaching up towards the embryo. This process leads to the creation of the placenta.

The placenta is the only purposely transient organ in humans and unlike the rest of our organs, acts as many organs in one. The placenta functions to eliminate waste, like the kidneys would do, facilitates transfer of oxygen and carbon dioxide, like the lungs would do, and provides nutrients, like a GI tract would do. It even has endocrine and immune function. What used to be discarded as just the afterbirth is now regarded as a magnificently complex shared organ that supports the formation of the prenatal child.

Even more amazing to me is the phenomenon of fetomaternal microchimerism, named after the chimera of Greek mythology, a creature comprised of three different species:

In science, microchimerism is the presence of a small population of genetically distinct and separately derived cells within an individual. During pregnancy, small numbers of cells traffic across the placenta. Some of the prenatal childs cells cross into the mother, and some cells from the mother cross into the prenatal child. The cells from the prenatal child are pluripotent and integrate into tissues in her mothers body and start functioning like the cells around them. This integration is known as feto-maternal microchimerism.

The presence of these cells is amazing for several reasons. One is that these cells have been found in various maternal organs and tissues such as the brain, the breast, the thyroid and the skin. These are all organs which in some way are important for the health of both the baby and her mother in relationship. The post-partum phase is when there is need, for example, for lactation. The fetomaternal microchimeric cells have been shown to be important in signaling lactation. These cells have been found in the skin, for example, in Cesarean section incisions where they are helping to produce collagen. Baby is helping mom heal after delivery by the presence of her cells! It would be one thing for these cells to come into the mother and be inert, but is a whole other thing entirely that these cells are active and aid mom for example in helping to produce milk for her baby and helping her heal. These cells may even affect how soon the mother can get pregnant again and therefore can affect spacing of future siblings.

To think that a physical presence of the baby in her mother is helping protect her from cancer at the level of the cell, speaks to a radical mutuality at the cellular level that we are just beginning to understand. . . .

The big takeaway is that the science of microchimerism supports the fact that some human beings carry remnants of other humans in their bodies. Thus, we arent the singular-autonomous individuals we think of ourselves as being.

I came across another article that said that if the mother suffers organ damage during pregnancy, the baby can send its stem cells to repair the damage! (The article included a link to this medical journal.)

The Crux interviewer, Charles C. Camosy, wanted to bring out the implications for Marys relationship with Jesus. Yes, said Prof. Collierwho is a Christian, but not a CatholicMary would always have a part of Jesus with her, indeed, as a part of her. But this intimate mutual union is also true, she said, for all mothers.All mothers carry their children with them, on a cellular level, for their whole lives. And just as she has contributed to the formation of the bodies of her children, they have contributed to the formation of hers.

Prof. Collier then makes a startlingly comforting application. Mothers whose children have died, she said, often feel that their children are still with them. We now know that they are.

Illustration via Good Free Photos, Public Domain

Originally posted here:
The Mutuality Between Mothers and Their Developing Babies - Patheos