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Archive for the ‘Male Genetics’ Category

Al Ain Zoo efforts to protect the Arabian sand cat – Udaipur Kiran

Al Ain Zoo launched its Arabian sand cat conservation programme to protect the sand cat in cooperation with its strategic partners through various workshops hosted by the zoo.

The workshops aimed to understand the current situation of the sand cat and combine all the knowledge we have in one document. One of the key objectives of the workshops was to conduct field research in order to study the wild population and the challenges and threats facing them. Additionally, conductstudy on the cats genetics and make recommendation on the management and breeding options.

Al Ain Zoo has contributed too many research-based and scientific publications that informs knowledge on wildlife conservation and animal management. One of the recent publications was on the analysis of the sand cat genetic to determine the validity of the subspecies of the sand cats.

Regarding genetic research, the zoo and relevant organizations have developed plans for genetic management and controlled breeding programs after examining the effects of genetic diversity and identifying the negative and reproductive challenges and opportunities. This was done by sending male kittens from the zoo to specialized research centers in France. The studies findings showed a match between the Arabian and Asian cats, though not the African ones.

The zoo is making deliberate efforts in cooperation with partners who specialize in this field at the local and international levels by adopting basic strategies to conserve the Arabian sand cat. This would be achieved by setting objectives and action plans and developing programs that focus on genetic studies and field research.

In collaboration with its key partners, Al Ain Zoo is continuing its efforts to study the wild population and develop plans for monitoring the sand cats in their natural habitats. The zoo has positioned itself as a global leader by embracing the largest group of Arabian sand cats in the world and has succeeded in its captive management and breeding programs. It is also planning to open a Sand Cat Breeding Centre, which will be the first of its kind.

The centre is devoted to the care and reproduction of these shy animals within strict criteria that also take into account their extreme sensitivity to respiratory infections by controlling the temperature and humidity of the shelters. The breeding centre contributes to increasing the numbers of sand cats in breeding programs and improving the genetic origins of this species, locally and globally.

Originally posted here:
Al Ain Zoo efforts to protect the Arabian sand cat - Udaipur Kiran

The Farce of July – LA Progressive

We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty, and the pursuit of Happiness.

Nothing fills me with a greater awe and sense of purpose than this ideal. It is the essence of my lifes work in teaching peace and justice. As an educator I believe that all of humanity is improved in recognizing equality in basic human rights and delivering on promises of equal opportunity. Unfortunately, however, this purpose doesnt generally register as patriotism; my country has failed to take equality seriously. Instead we promote mythology, an ongoing white liethe farcewhich asserts an America created as a model for humankind by wise and justice-minded Founding Fathers.

Early challenges to that myth by eloquent victims of the American reality include one from July 5, 1852, when former slave Frederick Douglass addressed the nation with his question, What to the Slave is the Fourth of July? at an Independence Day celebration:

Fellow-citizens! I will not enlarge further on your national inconsistencies. The existence of slavery in this country brands your republicanism as a sham, your humanity as a base pretense, and your Christianity as a lie.

Can we imagine that in 2020 minorities and persons of color are still asking for access to the American Dream, but also for permission to live?

Can we imagine that in 2020 minorities and persons of color are still asking for access to the American Dream, but also for permission to live? The nightmare of injustice is structural, systematic, intentional, and persistent, but were tolddecade after decadethat it is necessary to be patient and it is only a few bad apples.

We never acknowledge that the bad apples, just like the injustice, are produced in every city on every day.

The descendants of slaves carry the genetics raped into their family trees. Our streets are filled with signs honoring the rapists names. The farce says these ignoble criminals should be celebrated.

We do not teach that George Washingtons dentures were made from human teeth or ivory, tell the white lie that they are made out of wood instead of admitting there is a good chance they were purchased at cut-rate prices from slaves or, in the very best case, from desperately poor people.

We do not teach that while Benjamin Franklin eventually saw the moral need to abolish slavery, the equality pronounced in declaring independence did not extend to the slaves he owned until 1781. The White House was built with slave labor. Thomas Jefferson fathered children with Sally Hemings. How does a 16-year-old slave end up pregnant by her owner?

This social malady is present in the jokes about nooses and the insistence of those who tell them. Forget that there have been thousands of lynchings and that the racialized terror continues to traumatize communities of color. This buffoonery insists that it is not racist to joke, even when the jokes are about hate crimes. Some are inspired to mock the murder of George Floyd, posting photos of themselves kneeling on each others necks to mimic the murder of George Floyd, or to make jokes about not being able to breathe

The problems are not isolated. Messages of animus come from everywhere, the White House with its ongoing bigotry has no problem making clear that people of color should go back to where they came from regardless of whether or not they were born in the US. Police departments have used violent militaristic responses to peaceful Black Lives Matter gatherings, with some officers declaring they are ready for a civil war; We are just going to go out and start slaughtering them f n.

Sanctioning the history of the United States of America is always challenging. Sanction, contranym (a word with two different and contradictory meanings), is understood as both a threatened penalty and also as approval. Elaborate displays of patriotism tend toward the later, when progress demands the former. I am calling for negative sanctions on teaching American history from the point of view of white male propertied slaveowners. I would positively sanction teaching American history by equally honoring all the voices from all groups.

A gritty reality: A bunch of wealthy white slave owning capitalists got tired of paying taxes. They wrote a Constitution and created an Electoral College to protect the slave trade. It is time that we started telling the truth about the past and were honest about the present. A racist bully lost the popular vote by 3 million votes but occupies the office of the President because of an institution designed to perpetuate inequality.

We no longer have signs that say colored but we see the same outcomes in everything from life expectancy and the lethality of the coronavirus to wealth and incarcerations disparities. We have never atoned or made reparations for this past, it is time to take equality seriously.

Wim Laven

Wim Laven, Ph.D., syndicated by PeaceVoice, teaches courses in political science and conflict resolution.

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The Farce of July - LA Progressive

Hartmann’s Mountain Zebra Born at the Smithsonian Conservation Biology Institute – Smithsonian’s National Zoo and Conservation Biology Institute

For the first time in the Smithsonian Conservation Biology Institutes (SCBI) history, ungulate keepers celebrated the birth of a male Hartmanns mountain zebra at the Front Royal, Virginia, facility. The colt was born overnight July 2 to 6-year-old mother Mackenzie and 5-year-old father Rogan. He is the first offspring for both parents. Ungulate keepers are closely monitoring the colt, and they report that he appears to be nursing well and sticking close by Mackenzies side.

Before their arrival at SCBI, Mackenzie and Rogan received a recommendation to breed from the Association of Zoos and Aquariums Species Survival Plan (SSP). The SSP scientists determine which animals to breed by considering their genetic makeup, health, personality and temperament, among other factors. In October 2018, Mackenzie and Rogan were transferred to SCBI from the Elmwood Park Zoo in Pennsylvania and the Cleveland Zoo in Ohio, respectively. Females typically reach sexual maturity around 2 to 3 years of age, while males become sexually mature around age 4 or 5. The pair bred naturally in June and July of 2019; Hartmanns mountain zebra gestation is about one year.

Each zebra is a unique individual, and keepers are looking forward to seeing how the colts personality develops. While mother Mackenzie is feisty and a bit standoffish, father Rogan is quirky and easygoing. The colt lives with Mackenzie and an unrelated female, 7-year-old Xolani, in a herd. Since male zebras do not provide any parental care to their offspring, Rogan lives in a separate enclosure nearby. Although the colt sticks close by Mackenzies side now, keepers say they are excited to see the foal explore his surrounding and watch his curiosity grow. Over the next two months, the colt will start sampling grass and pellets.

As a public health precaution due to COVID-19, the Smithsonians National Zoo and Conservation Biology Institute is temporarily closed to the public.Animal keepers and veterinary staff remain working on site at the Zoo and SCBI to provide the usual highest quality care for the animals.Additional information on the Zoos COVID-19 response is posted to theZoos website. The Zoo will share updates on the colt on Facebook, Instagram and Twitter.

Hartmanns mountain zebras are a subspecies of the mountain zebra, which is one of three zebra species. Considered vulnerable by the International Union for Conservation of Nature, Hartmanns mountain zebras live in dry mountain habitats of Namibia. Unlike other zebra species, Hartmann's mountain zebras live in small herds, have vertical stripes on their neck and torso and horizontal stripes on their backside, and have a small fold of skin under their chin (called a dewlap). With less than 25,000 individuals left in the wild, the biggest threat to this species survival is habitat loss and fragmentation as the result of livestock production and agriculture.

The Smithsonians National Zoos legacy of conservation work extends beyond the public Zoo in Washington, D.C., to SCBI in Front Royal, Virginia. Scientists at SCBI study and breed more than 20 species, including some that were once extinct in the wild, such as black-footed ferrets and scimitar-horned oryx. Animals thrive in specialized barns and building complexes spread over more than 3,200 acres. The sprawling environment allows for unique studies that contribute to the survival of threatened, difficult-to-breed species with distinct needs, especially those requiring large areas, natural group sizes and minimal public disturbance.

SCBI spearheads research programs at its headquarters in Virginia, the Zoo in Washington, D.C., and at field research stations and training sites worldwide. SCBI scientists tackle some of todays most complex conservation challenges by applying and sharing what they learn about animal behavior and reproduction, ecology, genetics, migration and conservation sustainability.

# # #

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Hartmann's Mountain Zebra Born at the Smithsonian Conservation Biology Institute - Smithsonian's National Zoo and Conservation Biology Institute

In the Future, Lab Mice Will Live in Computer Chips, Not Cages – Undark Magazine

Animal models, especially mice, have given scientists valuable insights into the mechanisms behind countless human diseases. They have been instrumental to the discovery of drug targets, metabolic pathways, and gene function. Theyve helped to lay bare the basic biochemistry of metabolism, hunger, cognition, and aging. Because mice are, to a certain extent, miniature facsimiles of human anatomy and genetics, science has an array of tools at its disposal to manipulate and visualize their bodily processes in real time, in highly controlled settings.

But, as the recent Covid-19 pandemic has revealed, science doesnt always have the tools to minimize loss of animal life. As the pandemic took hold and academic research labs across the U.S. shuttered indefinitely, scientists were faced with an unprecedented animal care dilemma. Without the teams of veterinary nurses and technicians who usually attend to the animals daily, many labs were forced to resort to wholesale euthanasia. Some labs sacrificed hundreds of animals, and were criticized harshly for their management of their experimental colonies. Many started to consider more durable, long-term plans for preserving and storing their mouse lines.

In the lab where I work at the University of California, San Francisco, and where for the past two years Ive been the designated rodent surgeon, we were asked to euthanize all but our most irreplaceable mice. As new animal researchers, we are trained to sacrifice our mice humanely to give them a dignified death. Returning to lab after the shutdown to find rows of empty racks that once held cages of mice we had worked with for months was a shock, and it was hard to conjure dignity in that moment.

That experience led me to reflect on how we as a research community use animal models in biomedical research, and how we might better use them in the future. And Ive become increasingly convinced that the animal model of the future will live not in a cage but in a computer chip: By simulating biological systems rather than experimenting with them, we can make drug development and biomedical research safer, more efficient, and more effective.

This is not to say that researchers treatment of animals has been haphazard. Research in animal models is highly regulated. These regulations vary in austerity from country to country and institution to institution, but they revolve around a common set of principles known as the three Rs: Replace the use of animals when possible, reduce the number of animals used per experiment, and refine methods to minimize suffering and improve welfare.

As the recent Covid-19 pandemic has revealed, science doesnt always have the tools to minimize loss of animal life.

A few years ago, when I was a new mouse surgeon, the three Rs were the guiding tenets of a week-long course I took at the Ren Remie Surgical Skills Center in Almere, Netherlands. The centers founder, Ren Remie, advocated for meticulous surgical technique, held to the same standards of sterility and post-operative care as any human surgical procedure. But he was also a proponent of the thinking that longer-term strategies can hasten recovery time from infection and surgical procedures. For instance, Remie and other researchers advocate whats called environmental enrichment, a method that helps animals cope with the inherent stress of being isolated after a surgical procedure or during an experiment. The researchers place toys, nesting material, or other inanimate objects in the cage that allow the mouse to engage with its surroundings, similar to the way it would in the wild. Studies suggest that environmental enrichment may even promote wound healing in rats.

But the success of strategies like environmental enrichment highlights an inherent weakness of the animal research model: An animals behavior is often extremely sensitive to its environment, in ways that are difficult if not impossible to control. This raises a perennial issue in biomedical research of just how reliably conclusions drawn based on studies in mice can be faithfully applied to human disease treatment. For instance, rodents are housed in groups as a rule, but certain kinds of experiments and treatments require them to be isolated, triggering a stress response that could significantly affect their immune activation. Studies have shown that mice and rats who live with companions fare better against injury, stroke, and even tumor growth than their lonely counterparts. As a result, when mice studies ask questions about human diseases, the housing status of the mouse is often a confounding factor. Even slight variation in the ambient temperature of a mouses housing room can cause stress responses that affect experimental outcomes. This variability is one reason that treatments that seem promising in mice often produce underwhelming outcomes in human clinical trials.

One attractive complement to animal studies that may address some of these shortcomings is in silico, or on a chip medicine. In silico models apply computational modeling strategies to genomic data to predict physiological responses to drugs or other stimuli. Although they are far from being able to replicate the full complexity of a living, sentient being, the U.S. Food and Drug Administration has begun consider computer modeling-based strategies to update the cumbersome and costly clinical trial pipeline. Research with in vitro models, which attempt to replicate animal physiology in test-tube style experiments, have also shown promise. These efforts have given birth to projects like the Comprehensive in Vitro Proarrhythmia Assay initiative, which integrates modeling and in vitro strategies to evaluate the potential for new drugs to cause heart rate abnormalities

Likewise, in 2013, the European Commission assembled a consortium of research groups known as the Avicenna Alliance to unify academia and industry around a set of standards for computer modeling in medicine. Based in Belgium but comprised of independent organizations around the world, the goal of the Alliance is to enable virtual clinical trials whose results can be validated by the same kinds of rigorous standards that are applied to traditional clinical trials.

As the Avicenna Alliance envisions them, virtual clinical trials would be based on unique genetic models derived from individual patients, rather than on large, genetically variable sample groups. Conceivably, this could allow a researcher to simulate a patients unique response to a treatment strategy, capturing the effects of subtle variations in baseline metabolism, bodyweight, or underlying health conditions that might influence the patients treatment outcomes. It might also significantly reduce the time and expense traditionally required to usher a new drug or medical device from the lab bench to the clinic potentially lowering the barrier to care for large swaths of the population who cant afford the often-astronomical costs of life-saving medications.

In silico clinical trials, if and when they are realized, could also address the long-standing problem of sample bias in drug development. Demographically, clinical trials tend to be disproportionately White and, until recently, overwhelmingly male. They therefore dont fully capture the therapeutic value and potential risks that drugs present to the patients who eventually rely on them. If in silico strategies become widely adopted, theyll hold potential to both increase the efficacy of new drugs and expand access to treatment.

The ethical debate around the use of animals in research has roiled for hundreds of years and will likely continue to do so. But what the Covid-19 outbreak has made clear is that there are severe weaknesses in the current animal model paradigm. As experiments have come to a halt during the coronavirus lockdowns, researchers have been given time to consider new, more sustainable approaches to discovery. Hopefully, we will look beyond the short-term technical challenges that will inevitably accompany the resumption of business as usual and gaze further afield, toward more humane, more modernized approaches to doing science.

Lindsay Gray is a lab manager at the University of California, San Francisco.

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In the Future, Lab Mice Will Live in Computer Chips, Not Cages - Undark Magazine

The Farce of July | Columnists – Anchorage Press

We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty, and the pursuit of Happiness.

Nothing fills me with a greater awe and sense of purpose than this ideal. It is the essence of my lifes work in teaching peace and justice. As an educator I believe that all of humanity is improved in recognizing equality in basic human rights and delivering on promises of equal opportunity. Unfortunately, however, this purpose doesnt generally register as patriotism; my country has failed to take equality seriously. Instead we promote mythology, an ongoing white liethe farcewhich asserts an America created as a model for humankind by wise and justice-minded Founding Fathers.

Early challenges to that myth by eloquent victims of the American reality include one from July 5, 1852, when former slave Frederick Douglass addressed the nation with his question, "What to the Slave is the Fourth of July?" at an Independence Day celebration:

Fellow-citizens! I will not enlarge further on your national inconsistencies. The existence of slavery in this country brands your republicanism as a sham, your humanity as a base pretense, and your Christianity as a lie.

Can we imagine that in 2020 minorities and persons of color are still asking for access to the American Dream, but also for permission to live? The nightmare of injustice is structural, systematic, intentional, and persistent, but were tolddecade after decadethat it is necessary to be patient and it is only a few bad apples.

We never acknowledge that the bad apples, just like the injustice, are produced in every city on every day.

The descendants of slaves carry the genetics raped into their family trees. Our streets are filled with signs honoring the rapists names. The farce says these ignoble criminals should be celebrated.

We do not teach that George Washingtons dentures were made from human teeth or ivory, tell the white lie that they are made out of wood instead of admitting there is a good chance they were purchased at cut-rate prices from slaves or, in the very best case, from desperately poor people.

We do not teach that while Benjamin Franklin eventually saw the moral need to abolish slavery, the equality pronounced in declaring independence did not extend to the slaves he owned until 1781. The White House was built with slave labor. Thomas Jefferson fathered children with Sally Hemings. How does a 16-year-old slave end up pregnant by her owner?

This social malady is present in the jokes about nooses and the insistence of those who tell them. Forget that there have been thousands of lynchings and that the racialized terror continues to traumatize communities of color. This buffoonery insists that it is not racist to joke, even when the jokes are about hate crimes. Some are inspired to mock the murder of George Floyd, posting photos of themselves kneeling on each other's necks to mimic the murder of George Floyd, or to make jokes about not being able to breathe

The problems are not isolated. Messages of animus come from everywhere, the White House with its ongoing bigotry has no problem making clear that people of color should go back to where they came from regardless of whether or not they were born in the US. Police departments have used violent militaristic responses to peaceful Black Lives Matter gatherings, with some officers declaring they are ready for a civil war; We are just going to go out and start slaughtering them f------ n------.

Sanctioning the history of the United States of America is always challenging. Sanction, contranym (a word with two different and contradictory meanings), is understood as both a threatened penalty and also as approval. Elaborate displays of patriotism tend toward the later, when progress demands the former. I am calling for negative sanctions on teaching American history from the point of view of white male propertied slaveowners. I would positively sanction teaching American history by equally honoring all the voices from all groups.

A gritty reality: A bunch of wealthy white slave owning capitalists got tired of paying taxes. They wrote a Constitution and created an Electoral College to protect the slave trade. It is time that we started telling the truth about the past and were honest about the present. A racist bully lost the popular vote by 3 million votes but occupies the office of the President because of an institution designed to perpetuate inequality. We no longer have signs that say colored but we see the same outcomes in everything from life expectancy and the lethality of the coronavirus to wealth and incarcerations disparities. We have never atoned or made reparations for this past, it is time to take equality seriously.

Wim Laven, Ph.D., syndicated by PeaceVoice, teaches courses in political science and conflict resolution.

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The Farce of July | Columnists - Anchorage Press

A TEST FOR RARE MALE MATING ADVANTAGE WITH … – genetics.org

Recent work has called into question the reality of the rare male mating advantage, pointing out that it could be a statistical artifact of marking flies for behavioral observation or of experimental bias in collecting males. We designed an experiment to test for rare male mating advantage that avoids these sources of bias. Large numbers of males of three Drosophila pseudoobscura karyotypes were allowed to mate with females of one karyotype in population cages. The females were then isolated before multiple mating occurred and their progeny used to diagnose the males that mated them. Populations were studied at five sets of male karyotypic frequencies. The mating success of the male homokaryotypes ST/ST and CH/CH, relative to that of the heterokaryotype ST/CH, was frequency dependent. Both ST/ST and CH/CH males displayed a statistically significant mating advantage at low frequency by comparision with their mating success in the midrange of karyotypic frequencies. Both male homokaryotypes also showed a significantly greater mating success at high homokaryotypic frequency than at intermediate frequencies, which is the same as saying that the heterokaryotype not only failed to show a rare male advantage but actually suffered a mating disadvantage at low frequency. We conclude that rare male mating advantage is not always an experimental or methodological artifact but does occur in laboratory populations of D. pseudoobscura. It may occur for some genotypes and not for others, however, and it may be only one of several forms of frequency-dependent mating behavior operating in a population.

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A TEST FOR RARE MALE MATING ADVANTAGE WITH ... - genetics.org

Men’s Health Month: Mary Jane Minkin, M.D., OB/GYN Shares 5 Proactive Fertility Tips for Men When Trying to Conceive – Business Wire

NEW HAVEN, Conn.--(BUSINESS WIRE)--While infertility, or the inability to conceive after one year of trying used to be a womans problem, there is now a better understanding of the important role men play in conceiving. In at least half of all infertility cases, men are either the contributing or leading cause. To help couples better understand common fertility issues, Mary Jane Minkin, MD, OB/GYN, founder of MadameOvary.com, sheds light on male fertility factors and how men can be proactive in improving their fertility.

The well-known advice for couples trying to conceive are centered around the womans fertile window or when she should start to abstain from alcohol, says Mary Jane Minkin, MD, Clinical Professor of Obstetrics & Gynecology at Yale University. However, it takes two to tango, and couples should be aware of both female and male fertility issues to improve their odds of conceiving. As science and research continues to move forward in treating infertility, realize that there are ways to address male fertility, and that 90% of infertility cases are treatable with current medical therapies.

Dr. Minkin suggests the below tips to help men be proactive when it comes to their fertility:

The trying to conceive journey looks different for every couple, adds Minkin. Both partners should remember to be proactive about their health, modify their lifestyle accordingly, and if struggling to conceive, be supportive of one another and prioritize communication.

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Men's Health Month: Mary Jane Minkin, M.D., OB/GYN Shares 5 Proactive Fertility Tips for Men When Trying to Conceive - Business Wire

Excessive Sex Hormones Could Be Making Bald Men More Vulnerable to COVID-19 – VICE

VICE does not imply that Prince William has excessive sex hormones or COVID-19. Image viaSteve Parsons / POOL / AFP (cropped)

Towards the end of May, a study published by a team of Spanish researchers and dermatologists found that out of a sample of 122 male COVID-19 patients admitted to hospitals in Madrid, 79 percent were baldabout double the standard population frequency.

Four weeks later, another paper published in the Journal of Cosmetic Dermatology found bald men were similarly overrepresented among COVID-19 hospital admissions.

Both studies were small, and neither of them definitively confirmed the correlation between male pattern hair loss and susceptibility to coronavirus. But together they launched a shockwave of articles around the world proclaiming scientists fears that follicly challenged men might be at greater risk of catching, and dying from, COVID-19.

According to Jenny Graves, Professor of Genetics and Vice Chancellor's Fellow at Melbournes La Trobe University, the science more or less checks out: there may well be a plausible biological explanation for the apparent link between baldness and vulnerability to COVID. And it's got to do with sex hormones.

In a piece published for The Conversation, Dr Graves points out that male pattern hair loss is typically linked to a family of sex hormones called androgens. Androgens are commonly referred to as male hormones for the way in which they regulate the development of male characteristics, such as the development of sexual organs, the growth of the prostate, and balding.

High levels of androgen are strongly associated with hair loss. But studies suggest that these hormones might also play an important role in mediating the entry of SARS-CoV-2 (the virus that causes COVID-19) into cellsthus increasing the risk of severe infection and death.

Hence the theory that the more male hormones present in a persons body, the easier it is for the coronavirus to get in and take hold. As Dr Graves indicates, this could be one reason why men in general appear to be at greater risk of severe infection than women.

More research is needed to firm this upand Dr Graves hastens to point out that larger samples which control for age and other conditions, for one, would go a long way towards confirming whether the link between alopecia-causing androgens and COVID-19 is as significant as it appears. If it is, though, she also suggests that it might be worth looking at anti-androgens, as well as androgen deprivation therapy (ADT), as a way to potentially treat and prevent the disease.

Anti-androgens are a class of testosterone-blocking drugs that effectively prevent androgens from carrying out their biological effects in the body. Theyre already used to treat a range of conditions, including hair loss, overly high sex drive, problematic sexual urges, and prostate cancer. The idea, essentially, is this: if the hormones that cause balding also increase COVID-19 vulnerability, maybe the medicines we have to prevent balding could be used to protect against COVID-19.

Scientists are already exploring this possibility. In a study that looked at a sample of men hospitalised with COVID-19 in Italy, researchers observed that the rate of infection was four times lower in prostate cancer patients on ADT than in untreated cancer patients.

Our data suggest that cancer patients have an increased risk of SARS-CoV-2 infections compared with non-cancer patients. However, prostate cancer patients receiving ADT appear to be partially protected from SARS-CoV-2 infections, they concluded.

Results like this give credence to the idea that similar anti-androgen regimes and therapies could be used not only as treatment, but also prevention, of COVID-19.

Perhaps a single dose given to someone who tests positive to SARS-CoV-2, or has just been exposed, would suffice to lower the chance of the virus taking hold, Dr Graves speculates. But we need research to confirm this.

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Excessive Sex Hormones Could Be Making Bald Men More Vulnerable to COVID-19 - VICE

Mens Health: From Hanging Leg Raises to Reverse Crunches; Here Are 5 Exercises to Get V-Cut Abs (Watch – LatestLY

Which guy doesn't desire an aesthetic physique? For achieving this, a lot of dedication, discipline and will power is required. Most importantly, patience and a 'never say die' attitude is essential when you are aiming for the desired body.Let's take a look at five exercises for V-Cut absas we observe Men's Health Week 2020.Mens Health Week 2020: From Cleaning Foot to Keeping Your Armpit Fresh, Here Are Five Personal Hygiene Habits Every Male Should Follow.

V-Cut abs, also known as the adonis belt, sex lines, v cuts or v abs are the muscles on the lower sides of the abdomen that form a V-shape. V-Cut abs are aesthetically pleasing. In order to achieve this v-shape on abdominal muscles, one has to do rigorous workout and mainly concentrate on their diet. Apart from performing regular core exercises, it is also necessary to focus on deadlifts, squats, overhead press along with other compound exercises. It must also be noted that genetics play an important role in achieving V-Cut abs. Some people may easily develop this physique, however, there are some who have thicker skin around their abdomen or even have uneven abs, and might find it difficult to get that v-shape. Nevertheless, following below exercises with a good diet can help you achieve a strong core and perfectly well-defined rectus abdominis muscles.Men's Health Week 2020: From Cardiovascular Diseases to Erectile Dysfunction, Common Health Conditions Males Can Develop with Age!

Five Exercises For V-Cut Abs

1. Hanging Leg Raises

It is necessary to work on burning fat around lower abdominal muscles to get those v-cut abs. Performing three to four sets of hanging leg raises of 10-12 reps perfectly can help in removing lower belly fat.

2. Reverse Crunches

This exercise works not only on lower abdominal muscles but also on the upper and middle abs. It has to be performed smoothly without putting any stress on the neck to avoid injury. Reverse crunches should be performed in four sets of fifteen reps each.

3. Mountain Climber

This exercise is also included in high-intensity interval training. If performed with pace, it shoots the heart rate and effectively helps in fat loss.

4. Leg Flutters

This exercise might look simple,but it effectively works on lower abdominal muscles. Leg flutters should be regularly included in your core training for achieving V-shape abs.

5. Seated Leg Tucks

Seated leg tucks work on obliques, middle abs, upper abs and also on the lower abs. Stability and good balance are required while performing this exercise.

In order to achieve V-Cut abs, make sure that you include fresh green vegetables in your diet regularly and eat food cooked in very less oil. Cold drinks, desserts, bakery products and refined flour should be a strict no if you are aiming for those six-pack or eight-pack abs. Even if you don't reach V-Cut shape abs, you shouldn't get disheartened as these routines will at least help in reducing your visceral fat percentage that can significantly reduce the risk of heart diseases. For better results, it is recommended to get trained under a fitness trainer and get a proper diet plan from a dietician.

(The above story first appeared on LatestLY on Jul 01, 2020 09:36 AM IST. For more news and updates on politics, world, sports, entertainment and lifestyle, log on to our website latestly.com).

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Mens Health: From Hanging Leg Raises to Reverse Crunches; Here Are 5 Exercises to Get V-Cut Abs (Watch - LatestLY

Around Town: Fathers matter – VVdailypress.com

Males, who have long been branded as the dominant gender in our species, have been undervalued since Eve turned Adam in to a hapless co-conspirator in the downfall of humanity.

We have a reputation of being driven by our animal passions and prejudices. Females get the credit for compassion and reason. With few exceptions in history, wars have not been started by women in power.

America has changed dramatically in its view of fatherhood and the responsibility the title entails. The one thing that remains constant in our society, and among our species, is that the young need direction, training, leadership and nurturing from a parent to thrive and sometimes even to survive.

Sadly, we are all products of our upbringing no matter how hard we try to remake ourselves as age and reason overtake us. My mother, God bless her, was a product of a five-sister home in the 30s. Getting out and getting a husband was vital. A man in her life was a life-long priority.

She had five husbands and a few other long-term relationships over her long life. I had three half-siblings fathered by her first husband. Then I came along with husband two after World War II. In a sense, I consider myself lucky because as I grew up, I had several choices of male role models. Some were winners, some were not. I got the genetics of being a big, garrulous hard drinker from my Irish birth father who drifted in and out of my life until he died after a drunken fall at age 47.

Sensing my needs, Mother then found a genial, well-known fellow who was the pillar of the community to take us in. It is his name, Orr, that I adopted when I came of age because it became clear to me even then that there are sperm donors and there are fathers. Do not confuse one with the other. Fathers contribute. They stay. They help. They teach and lead by example.

Ray Orr was a cop. He and his family of two older brothers were icons in Ontario for their contributions to youth sports. I was immediately accepted as a "good guy" when I entered high school simply trading on the goodwill of my new last name. It was an unimaginable gift. Acceptance, belonging and mentoring all in one fell swoop.

Ray also gave me one sage piece of advice that helped me keep on the straight and narrow through high school and college, an era of "free love" and doobies. He sat me down and said, "Pat, dont ever call me from jail because no one is coming. You are responsible for your actions."

That is fatherhood in my view.

I had another cop involved throughout my life that taught me about responsibility and hard work. My mom worked for the LAPD at the old Georgia Street Jail in the early 1950s and became friends with a sergeant named Lloyd Lindsey. He was a go-getter.

He and his wife had a third child and needed extra cash. He chose to take his vacation and work at a food stand at the Los Angeles County Fair owned by a fellow cop. Lloyd was so intrigued by the food business that he borrowed some money and opened his own food stand the following year.

To work there he recruited people he knew that could be fast and honest. He asked my mom to work weekends. She was between husbands and brought me along. I cleaned tables and Lloyd gave me a quarter a day. I worked for him on and off all the way through high school and during college breaks. I learned a great deal about customer service and marketing your product. He always gave me more responsibility when he knew I was ready.

Years later, I married his daughter and Lloyd encouraged and mentored us in our first food concession business. That turned into his helping us investigate a fast food franchise opportunity, which led us to become a multi-store operator in the High Desert.

Lloyd Lindsey taught me to work hard, to live your dream and to not to be afraid of taking a chance on yourself. That is being a father.

Right now, you are hearing a lot about "systemic racism" in America. It would be nice to have an honest conversation about the state of fatherhood in the African American community. About 70% of African American children are born out of wedlock, while married couples of color are having fewer children than ever.

Unfortunately, it seems to me that well-intentioned liberals have designed a welfare system that punishes women who choose to get married to the father to their child. The rise in illegitimate births affects all races in America, but it is particularly apparent in the African American community.

Children from two-parent families are more likely to finish high school and get some college, less likely to commit a crime or go to prison and more likely to become productive hard-working contributing members of the community in which they choose to live. Why is it so hard to redirect some of the billions we have spent over the last 60 years on social programs for the poor to family building, which is proven to break the poverty cycle?

Is it a coincidence that prior to 1965, when the "War on Poverty" swung into full gear, the social stigma against unwed mothers resulted in most pregnant couples getting married? In the 1960s and 1970s, the culture changed. Moral values changed and unwed pregnancies began to skyrocket. Benefits for dependent children were created.

There is no question that money is a major consideration to the rise of illegitimate births. It is less expensive to cohabitate than marry. The marriage commitment also binds people legally to be responsible for minor children. Commitment to anything but self has become less popular in our culture as the decades have passed. Abortion is a normal option now for unwanted pregnancy, which makes irresponsible sexual activity by men and women an accepted norm.

Why does marriage make a difference? Studies indicate that there is a 39% chance of the family breaking apart if the parents are not married. That number plummets to just 13% for married couples. Figures can be manipulated, but the clear relationship between fatherless homes, poverty, crime and poor life skills is all too evident in our major cities. The poorest city in America, Washington D.C., also has the highest rate of out-of-wedlock births. Coincidence? This cycle must be broken to achieve real racial equality.

On this day, when we celebrate fatherhood, we must ask ourselves if we have the courage to stand up and recognize that part of the reason for the disparity in the progress of minority children is the absence of two parents.

When do we return to the social and moral pressure in every community to get fathers to simply show up and be a father? How do we help that happen?

This does not mean that a white picket fence and minivan are the goals for every relationship. It means we should help young girls and women demand the self-respect of a commitment from any man with whom they partner marriage or no marriage.

Just find ways to encourage every father of every race to stand up and show up. Be a father for the future of your children, if not for yourself. That would be a great Fathers Day gift for America.

Contact Pat Orr at AVReviewOpinion@gmail.com.

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Before genetically modified mosquitoes are released, we need a better EPA – The Boston Globe

While the attention of the American public has rightfully been focused on the COVID-19 pandemic, its associated racial disparities, and broader issues of structural racism, the US government made a serious public health decision one that could affect our health and our environment for generations to come.

Last month, the US Environmental Protection Agency approved the release of genetically modified mosquitoes. Under a 2-year Experimental Use Permit, a company called Oxitec has been granted permission to release over 1 billion genetically modified mosquitoes across 6,600 acres in Florida and Texas.

Oxitec hopes to demonstrate through field trials that their latest GM mosquito strain can reduce local populations of Aedes aegypti the mosquito species that transmits dengue fever, yellow fever, chikungunya, and the Zika virus. When males of this GM mosquito strain (OX5034) are continually released to mate in the wild, they pass on a lethal gene to their female offspring that causes female larvae to die before they can develop into biting adults. Male mosquito offspring survive, but male mosquitoes dont bite and without viable females, the population should eventually collapse.

EPA approval of the release of this new GM mosquito is just the first step toward Oxitec selling its proprietary mosquito to US mosquito-control boards, and by extension US taxpayers. Oxitec intends to deploy its GM mosquitoes in and around the Florida Keys and near Houston. If the appropriate local authorities agree, millions of GM mosquitoes could be released into the wild every week starting this summer.

With our combined scientific and policy expertise, neither of us is anti-genetically modified organisms. We eat GM foods and believe that GM technologies can have significant benefits to public health but only if they are used safely and fairly. The environmental introduction of the first GM mosquito in the United States is a landmark decision. Its public health, ecosystem, and societal risks and benefits should be carefully weighed.

In a recent press release, Oxitec claims its strategy is a safe and environmentally sustainable way to control mosquitoes that transmit disease. Yet the EPA did not convene an independent, external scientific advisory panel to review Oxitecs claim; the agencys risk assessment was only made publicly available after their approval decision and we know of no peer-reviewed articles on this particular GM mosquito strain.

Meanwhile, GM mosquitoes are being introduced into uncontained, shared environments that people live in and depend on. The EPA recently held a written public comment process that yielded over 31,000 comments where some worried the impacts of GM mosquito suppression could threaten food webs and strain already vulnerable ecosystems. Others feared GM mosquitoes, or their genetic material, could integrate into the wild; GM-wild hybrid mosquitoes could prove more difficult to control or better at spreading disease. (Several years ago, public meetings and a nonbinding referendum took place in Florida over a different Oxitec mosquito strain. Residents of Key Haven, the site of proposed trials, voted against the release.)

Oxitec has trialed their second generation GM mosquito in Brazil and succeeded in reducing local populations of Aedes aegypti. Given Brazils high mosquito-borne disease burden the country reported over 1.5 million probable cases of dengue fever in 2016 the potential benefits of GM mosquitoes may outweigh their unknown ecological risks. Yet in the United States, dengue outbreaks are relatively rare, yellow fever has been eradicated domestically, and 231 of documented Zika virus cases were caused by local mosquito transmissions, as opposed to those associated with travel. It is unclear whether the potential benefits of release in the United States (one could be chemical pesticide reductions) will outweigh the risks. These tradeoffs must be weighed in a public setting.

And herein lies our concern: Risks should not be assessed behind closed doors between technology developers and EPA employees. As designed, the EPA risk assessment process privileges private entities over the American public.

Several recommendations could be implemented to make the regulatory process more open, rigorous, and fair.

For starters, an external independent group of experts should be convened to review the first GM mosquitoes presented for release. To address the complexity of such a decision, this group should consist of interdisciplinary experts representing diverse identities with expertise in ecology, genetics, vector biology, risk assessment, entomology, public health, ethics, and social science. External peer review is a cornerstone of good science and could ensure that all necessary risks are being addressed.

To ensure rigorous review, the EPA and other regulatory bodies must also fund independent third-party research on GM mosquitoes and their potential impact on US ecosystems and human health. Potential risks are too important to be left to corporations alone to research, and the American public needs to be assured that these decisions are made free of conflicts of interest.

Lastly, and perhaps most important, people who live in areas of release must be consulted for their specialized, on-the-ground knowledge and for their right to have input in decisions that will affect them. Last week, the Florida Department of Agriculture and Consumer Services approved the EPA permit for experimental release. Oxitec must now get approval from the Florida Keys Mosquito Control Board. An independent group should host public conversations through local community venues, and it must make sure that structurally marginalized perspectives are at the center of those gatherings. But local community input should be consulted at every stage of the regulatory process, not after permits have already been granted. And earmarked government funding should support these local deliberations, as well as measures to amplify underrepresented perspectives in environmental regulation and biotechnology.

GMOs made with even more powerful genetic technologies like CRISPR gene editing and gene-drives are being created in the laboratory and considered for open-environmental release. The public needs to know that the risks and benefits of these decisions will likely impact us all, and certain communities even more so. The COVID-19 pandemic has made it clear that robust public health depends on informed communities who participate in collective actions. Release of GM mosquitoes is no different. For the health of ourselves, the nation, our planet, and future generations, environmental regulation of GMOs must be made more rigorous and just.

Natalie Kofler is founder of Editing Nature and an adviser for the Scientific Citizenship Initiative at Harvard Medical School. Jennifer Kuzma is a professor in the School of Public and International Affairs and co-director of the Genetic Engineering and Society Center.

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Before genetically modified mosquitoes are released, we need a better EPA - The Boston Globe

A clinical trial of hydroxychloroquine has been halted after the drug was deemed ‘very unlikely to be benefici – Business Insider India

A clinical trial of hydroxychloroquine for the treatment of hospitalized adults with COVID-19 has been halted after the drug was found to be ineffective, the National Institutes of Health (NIH) announced on Friday.

According to the NIH's press release, the drug poses "no harm" to those who have taken it, but has still been deemed "very unlikely to be beneficial" to those being treated for coronavirus.

The study aimed to enroll "more than 500 adults who are currently hospitalized with COVID-19," and had enrolled more than 470 patients before it was halted, according to the NIH.

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Though hydroxychloroquine is typically used to treat malaria and rheumatoid conditions like arthritis, according to the NIH, it had been tested to treat COVID-19 because "the drug had demonstrated antiviral activity, an ability to modify the activity of the immune system."

In recent months, hydroxychloroquine has been provided to a wide range of people across the US including 1,300 veterans infected with COVID-19.

"I take it," he said at the time. "I would've told you that three, four days ago, but we never had a chance because you never asked me the question."

More recently at the start of June, White House physician Sean Conley confirmed in a memo that Trump had been prescribed hydroxychloroquine, zinc, and vitamin D, for a two-week period. The note also stated that Trump "remains healthy" with "no findings of significance or changes to report" from his annual physical, as Business Insider's Grace Panetta previously reported.

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A clinical trial of hydroxychloroquine has been halted after the drug was deemed 'very unlikely to be benefici - Business Insider India

Fighting Fish Synchronize Their Combat Moves and Gene Expression Leading to Tightly Meshed Battles – SciTechDaily

This is a Siamese fighting fish.

Betta fish opponents undergo similar brain changes that become more synchronized after longer fights.

When two betta fish are fighting for dominance, not only do their attacks mirror each other, but the gene expression in their brain cells also starts to align. The new findings, published June 17th in PLOS Genetics by Norihiro Okada of Kitasato University, Japan, may explain how the fish synchronize their fighting behavior.

The fighting fish Betta splendens is famous for its aggression, but opponents typically stop fighting after assessing the others abilities to avoid any serious injuries. The small freshwater fish is commonly used to study aggression in the lab, and it employs a handful of standard tactics like mouth-locking, bites, strikes, and swimming to the surface to gulp air. In the new study, researchers observed that during a fight, two male opponents modify their actions to match the aggressive behavior of the other, leading to tightly synchronized battles.

Furthermore, when the researchers analyzed the brains of both opponents, they observed that the fish also synchronized which genes were turned on or off in brain cells. The fighting pair had similar changes in gene activity related to learning, memory, synapse function and ion transport across cell membranes. The synchronization was specific to a fighting pair and became stronger after fighting for an hour compared to a 20-minute fight, suggesting that the degree of synchronization was driven by fighting interactions.

The new study takes a neurogenomic approach to the old question of how animals synchronize their behavior. Similar mirrored behaviors also occur during mating, foraging and cooperative hunting, and these behaviors may also trigger synchronized brain changes in the pairs of animals. One of my future plans is to elucidate what happens in the male-female interaction of fish on the molecular level, said author Norihiro Okada.

The findings suggest that even though the betta fish are fighting each other, sometimes to the death, their brains may be cooperating at the molecular level.

Reference: Behavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens by Trieu-Duc Vu, Yuki Iwasaki, Shuji Shigenobu, Akiko Maruko, Kenshiro Oshima, Erica Iioka, Chao-Li Huang, Takashi Abe, Satoshi Tamaki, Yi-Wen Lin, Chih-Kuan Chen, Mei-Yeh Lu, Masaru Hojo, Hao-Ven Wang, Shun-Fen Tzeng, Hao-Jen Huang, Akio Kanai, Takashi Gojobori, Tzen-Yuh Chiang, H. Sunny Sun, Wen-Hsiung Li and Norihiro Okada, 17 June 2020, PLOS Genetics.DOI: 10.1371/journal.pgen.1008831

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Fighting Fish Synchronize Their Combat Moves and Gene Expression Leading to Tightly Meshed Battles - SciTechDaily

We need to establish a win-win proposition by fostering partnership models to address healthcare gaps : Pree.. – ETHealthworld.com

In an interaction with ETHealthworld, Preetha Reddy, Vice Chairperson, Apollo Hospitals and President, NATHEALTH, discusses the need to prioritize healthcare by collaborative approach.

As the new president of NATHEALTH, what will be your key priorities in the coming months?Over the course of the next few months, our priorities will be to continue our work towards bringing everyone in the healthcare ecosystem, to a unified platform through integration, collaboration and re-imagination. The road ahead for NATHEALTH is to be a competency centre par excellence for public-private partnerships, nurturing the innovation ecosystem in healthcare and driving new programs to bring in Government support and expanding our aperture. With this vision in mind, NATHEALTH will focus its efforts to bring together all the stakeholders and build the national health agenda.

How important is the need for Government and the private sector engagement in the present times? How is NATHEALTH going to take this forward?The path to achieve a holistic goal of universal healthcare, hinges on collaboration where all the key industry stakeholders come together, deliberate, cooperate and work in tandem to bridge the vital gaps in service delivery. An equally important task is to establish a collaborative platform to coordinate national resilience in the present times, through value based public private partnerships.

As a unified ecosystem, we will sharpen our focus on thought leadership, create new markets and tech access, robust communication, transparency in governance and forge partnerships with smaller organizations and nursing associations, to take this movement forward.

What is urgently needed to revamp Indian healthcare today, in your opinion?It is essential to rebuild trust among key stakeholders, work towards making universal health coverage a fundamental right and creating value for healthcare services. We will make continued efforts to help people understand the valuable contributions that the private health sector makes in handling critical cases and saving countless lives. We need to establish a win-win proposition by fostering partnership models which address healthcare gaps and driving a dialogue that is based on mutual respect and capabilities.

What are the recommendations from NATHEALTH towards collaborative initiatives to address the impact of COVID 19? The healthcare sector is currently tackling the twin challenges of lower productivity due to systemic shock to earnings and major cash flow challenges at a time when COVID-19 needs the entire sector to be motivated and secured as a united front. We believe that the public and private sectors will need to work in partnership to ensure existing challenges are managed better in future and universal health coverage becomes a reality.

This pandemic has made us realize that as stakeholders, the hospitals, med-tech companies, pharma, IT, the medical academia and nursing councils have to join hands, chalk out a plan and work towards it collectively. Collaboration is the way forward.

There is also a need to lay the foundation for building the infrastructure and financial capability with an immediate action plan to tackle such large public health emergencies, now and in the future.

In view of the several challenges facing the private healthcare industry, how does NATHEALTH plan on addressing these issues?Our plan is to actively engage with our four key stakeholder groups: Policymakers, Partners, People and Members to encourage a collaborative approach in addressing these issues. We will work with policymakers to shape industry policies and forge new partnerships with State Governments. We plan to expand our membership base to new markets over the upcoming months to enable smaller and medium healthcare providers to become part of the federations ecosystem, and identify new operating models, technology and knowledge through our members.

Overall, I believe, in order to work towards sustainable healthcare, we have to look at increased public-private partnerships and look at ways to bring the Government, academia and industry together. It is important for us as a nation to prioritize healthcare, bring in increased health investments, scale up medical education and leverage technology to establish much more health infrastructure.

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We need to establish a win-win proposition by fostering partnership models to address healthcare gaps : Pree.. - ETHealthworld.com

Male Breast Cancer Treatment Market Size : Technological Advancement and Growth Analysis with Forecast to 2025 – Cole of Duty

This research report based on Male Breast Cancer Treatment market and available with Market Study Report, LLC, includes latest and upcoming industry trends in addition to the global spectrum of the Male Breast Cancer Treatment market that includes numerous regions. Likewise, the report also expands on intricate details pertaining to contributions by key players, demand and supply analysis as well as market share growth of the Male Breast Cancer Treatment industry.

Male breast cancer (male breast neoplasm) is a rare cancer in males that originates from the breast. Many males with breast cancer have inherited a BRCA mutation, but there are other causes, including alcohol abuse and exposure to certain hormones and ionizing radiation.

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Details regarding the industry size, remuneration potential, and volume share are compiled in the report. It further lists out the drivers and challenges that will impact the growth of Male Breast Cancer Treatment market during the estimated timeframe.

The Male Breast Cancer Treatment market with respect to the geographical terrain:

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Key Players: Here, the report throws light on financial ratios, pricing structure, production cost, gross profit, sales volume, revenue, and gross margin of leading and prominent companies competing in the Male Breast Cancer Treatment market.

Market Segments: This part of the report discusses about product type and application segments of the Male Breast Cancer Treatment market based on market share, CAGR, market size, and various other factors.

Research Methodology: This section discusses about the research methodology and approach used to prepare the report. It covers data triangulation, market breakdown, market size estimation, and research design and/or programs.

For More Details On this Report:https://www.marketstudyreport.com/reports/global-male-breast-cancer-treatment-market-2019-by-company-regions-type-and-application-forecast-to-2024

Some of the Major Highlights of TOC covers:

Male Breast Cancer Treatment Regional Market Analysis

Male Breast Cancer Treatment Segment Market Analysis (by Type)

Male Breast Cancer Treatment Segment Market Analysis (by Application)

Male Breast Cancer Treatment Major Manufacturers Analysis

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Male Breast Cancer Treatment Market Size : Technological Advancement and Growth Analysis with Forecast to 2025 - Cole of Duty

Aerobic antelopes and synchronised fish – Cosmos

These stories have nothing in common other than that they are fascinating examples of the way animals have evolved to suit their environments and lifestyles.

Researchers say they have discovered how Tibetan antelopes are able to run hard and fast despite living at altitude, and why Siamese fighting fish fight like they do.

In the first case, its a bit about staying young.

A study published in the journal Science Advances suggests that Pantholops hodgsonii has overcome oxygen deprivation on the high-altitude Tibetan Plateau through an unusual adaptation in which it permanently expresses a form of haemoglobin that other members of the cattle family only express as juveniles, or when under extreme oxygen deprivation.

Through a comparative genomic analysis with other bovids, Anthony Signore and Jay Storz from the University of Nebraska, US, found that the region that encodes for the adult form of haemoglobin was deleted in the antelopes ancestor, causing the juvenile form of the protein, which has a higher oxygen affinity, to take its place in adult red blood cells.

In other words, they say, a reversible response to oxygen deprivation previously documented in adult goats and sheep became a permanent genetic fixture in a mammal that is native to a region that ranges between 3600 and 5500 metres above sea level.

Through in vitro experiments, they confirmed that the antelopes haemoglobin does have a much higher oxygen affinity than that of all other bovids, perhaps explaining how it can run at 70 kilometres an hour over great distances, at altitudes where the partial pressure of oxygen is roughly half that at sea level.

In the second study, published in the journal PLOS Genetics, researchers from Japan, Taiwan, Saudi Arabia and the US reveal that when Siamese fighting fish are fighting, the gene expression in their brain cells starts to align.

Betta splendens is famous for its aggression, but male opponents modify their actions to match each others behaviour leading to tightly synchronised battles and typically stop fighting after assessing the others abilities to avoid any serious injuries, the researchers say.

When they analysed their brains, they observed that the opponents had similar changes in gene activity related to learning, memory, synapse function and ion transport across cell membranes.

This was specific to a fighting pair and became stronger after fighting for an hour, compared to 20 minutes, suggesting the degree of synchronisation is driven by fighting interactions.

Similar mirrored behaviours occur during mating, foraging and cooperative hunting, and these may also trigger synchronised brain changes in the pairs of animals.

One of my future plans is to elucidate what happens in the male-female interaction of fish on the molecular level, says lead author Norihiro Okada, from Kitasato University, Japan.

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Aerobic antelopes and synchronised fish - Cosmos

SMD – Higher rates of severe COVID-19 in BAME populations remain unexplained – QMUL

19 June 2020

The findings, published in the Journal of Public Health, suggest that the relationship between COVID-19 infection and ethnicity is complex, and requires more dedicated research to explain the factors driving these patterns.

Growing international reports highlight higher risk of adverse COVID-19 infection in BAME populations. The underlying cause of this ethnicity disease pattern is not known. Variation in cardiovascular disease risk, vitamin D levels, socio-economic, and behavioural factors have been proposed as possible explanations. However, these hypotheses have not been formally studied in existing work.

Investigators from Queen Mary, in collaboration with the Medical Research Council Lifecourse Epidemiology Unit at the University of Southampton, used the comprehensive and unique UK Biobank cohort of over half a million people to investigate the role of a range of socioeconomic, biological, and behavioural factors in determining the ethnicity pattern of severe COVID-19. The dataset included 4,510 UK Biobank participants who were tested for COVID-19 in a hospital setting, of whom 1,326 had a positive test result.

The results demonstrate that BAME ethnicity, male sex, higher body mass index, greater material deprivation, and household overcrowding are independent risk factors for COVID-19. The higher rates of severe COVID-19 in BAME populations was not adequately explained by variations in cardiovascular disease risk, vitamin D levels, socio-economic, or behavioural factors, suggesting that other factors not included in the analysis might underlie these differences.

Dr Zahra Raisi-Estabragh, BHF Clinical Research Training Fellow at Queen Mary University of London, led the analysis. She said: There is increasing concern over the higher rate of poor COVID-19 outcomes in BAME populations. Understanding potential drivers of this relationship is urgently needed to inform public health and research efforts. This work goes some way in addressing some of these pertinent questions.

Steffen Petersen, Professor of Cardiovascular Medicine at Queen Mary University of London, who supervised the work added: The results of this analysis suggest that factors which underlie ethnic differences in COVID-19 may not be easily captured. In addition to assessment of the role of biological considerations such as genetics, approaches which more comprehensively assess the complex economic and sociobehavioural differences should now be a priority.

Nicholas Harvey, Professor of Rheumatology and Clinical Epidemiology at the MRC Lifecourse Epidemiology Unit, University of Southampton, was a key collaborator in the work. He comments: The detailed participant characterisation in the UK Biobank and the rapid linkage of this data with COVID-19 test results from Public Health England permitted consideration of potential importance of a wide range of exposures.

The work was also supported by the National Institute for Health Research (NIHR) through the Barts Biomedical Research Centre, NIHR Southampton Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre.

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SMD - Higher rates of severe COVID-19 in BAME populations remain unexplained - QMUL

Genetically Modified Mosquitoes Approved For Insect Population Control In The U.S. – HuffPost

Genetically modified mosquitoes with the ability to prevent other mosquitoes from spreading deadly diseases may be making their way to Florida backyards in the near future.

British biotech group Oxitec announced on Tuesday that the company had won both federal and state approval to release its so-called Friendly mosquitoes in the U.S. on an experimental trial basis, expected to last until 2022, according to documents provided by the Environmental Protection Agency. The insects will first be released in Monroe County, Florida, and Oxitec has plans to also bring them to Harris County, Texas.

Oxitecs project involvesAedes aegypti, the mosquito that spreads yellow fever, dengue fever and Zika, among other diseases. While femaleAedes aegyptifeed on blood and are the transmitters of such illnesses, maleAedes aegypti are harmless, and Oxitecs Friendly mosquitoes are males who have been altered to carry a specificself-limiting gene, according to a description on the companys website. This gene will reduce the lifespan of any female offspring they might foster, but will live on in males, offering ... self-limiting generations of suppression that can lower the generalAedes aegypti population over time, theoretically leading to a decrease in the diseases that the insects are known for.

There is broad consensus amongst public health officials in the U.S. that a new generation of safe, targeted and cost-effective vector control tools are needed urgently to combat the growing threat posed by Aedes aegypti without impacting the ecosystem, Grey Frandsen, Oxitec CEO, said in the companys announcement. Were pleased that the EPA and Florida state regulators have, after extensive scientific reviews, approved our demonstration trials and we look forward to continuing the collaboration with our local partners as they take up the matter.

This novel method of mosquito population control was recently tested in the municipality of Indaiatuba, near So Paulo, Brazil, from May 2018 to 2019. In one of the tested communities, Oxitec observed that the genetically modified mosquitoes managed to suppress the population of Aedes aegyptiup to 96% within a four-week period.

Oxitecs work in mosquito genetics is not without controversy, and the company has targeted Florida as a testing ground for nearly a decade. AChange.org petition urging the EPA to reject the companys proposals, originally posted online in 2012, has received over 230,000 signatures, and the EPA is facingpre-litigation from advocacy groups, including the Center for Food Safety and Friends of the Earth U.S., for approving Oxitecs latest proposal.

Jaydee Hanson, policy director for the Center for Food Safety, called the mosquito project a Jurassic Park experiment in a statement. Hanson argued that by not carrying out in-depth consultations with local wildlife agencies before allowing Oxitec free rein with its insects, the EPA had unlawfully refused to seriously analyze environmental risks.

The Florida Keys and Houston and the surrounding communities are home to some of the most diverse and threatened species in our country, Dana Perls, food and technology program manager of Friends of the Earth U.S., echoed in the same statement. Once again, the Trump administration is callously disregarding scientific experts and the will of communities to force this risky experiment through.

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Genetically Modified Mosquitoes Approved For Insect Population Control In The U.S. - HuffPost

Newgrange tomb body belonged to royal-like male born of incest – The Irish Times

The genetic make-up of an adult male buried in the heart of the ancient Newgrange passage tomb indicates he was among a ruling social elite and in-bred in a similar way to Inca god-kings and Egyptian pharaohs.

This remarkable discovery shedding new light on the earliest periods of Irelands human history has been made by archaeologists and geneticists led by a team in Trinity College Dublin. Their genetic analysis shows he was born as a consequence of first-degree incest.

Older than the pyramids, Newgrange passage tomb in Co Meath is world famous for its annual solar alignment where the winter solstice sunrise illuminates its sacred inner chamber in a golden blast of light. However, little is known about who was interred in the heart of this imposing 200,000-tonne monument or of the Neolithic society which built it more than 5,000 years ago.

The survey of ancient Irish genomes using DNA sequencing technology on bone samples suggests a man who had been buried in this chamber belonged to a dynastic elite, according to Dr Lara Cassidy of TCD, lead author of the research published by Nature scientific journal on Wednesday.

Id never seen anything like it, she said. We all inherit two copies of the genome, one from our mother and one from our father. This individuals copies were extremely similar, a tell-tale sign of close inbreeding. In fact, our analyses allowed us to confirm that his parents were first-degree relatives.

Matings of this type (such as brother-sister unions) are a near universal taboo for cultural and biological reasons. The only confirmed social acceptances of first-degree incest are found among the elites typically within a deified royal family, Dr Cassidy explained.

By breaking the rules, the elite separates itself from the general population, intensifying hierarchy and legitimising power. Public ritual and extravagant monumental architecture often co-occur with dynastic incest, to achieve the same ends, she added.

Here the auspicious location of the male skeletal remains is matched by the unprecedented nature of his ancient genome, said professor of population genetics at TCD Dan Bradley.

The prestige of the burial makes this very likely a socially sanctioned union and speaks of a hierarchy so extreme that the only partners worthy of the elite were family members.

The team also unearthed a web of distant familial relations between this man and others from sites of the passage tomb tradition across the country, namely the mega-cemeteries of Carrowmore and Carrowkeel in Co Sligo, and the Millin Bay monument in Co Down.

It seems what we have here is a powerful extended kin-group, who had access to elite burial sites in many regions of the island for at least half a millennium, Dr Cassidy said.

The monument builders were early farmers who migrated to Ireland and replaced hunter-gatherers who preceded them.

Remarkably, a local myth resonates with these results and the Newgrange solar phenomenon. First recorded in the 11th century AD, four millennia after construction, the story tells of a builder-king who restarted the daily solar cycle by sleeping with his sister. The Middle Irish place name for the neighbouring Dowth passage tomb Fertae Chuile is based on this lore and can be translated as Hill of Sin.

Given the world-famous solstice alignments of Br na Binne, the magical solar manipulations in this myth already had scholars questioning how long an oral tradition could survive, said Dr Ros Maoldin, an archaeologist on the study. To now discover a potential prehistoric precedent for the incestuous aspect is extraordinary.

The genome survey has unearthed other unexpected results. Within the oldest known burial structure on the island, Poulnabrone portal tomb, the earliest yet diagnosed case of Down Syndrome was discovered in a male infant who was buried there 5,500 years ago. Isotope analyses suggest the infant was breast-fed.

It was conducted in collaboration with researchers at University College London; NUIG, UCC, University of Cambridge, Queens University Belfast, Sligo IT and the National Monuments Service with support from the National Museum of Ireland and National Museums Northern Ireland.

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Newgrange tomb body belonged to royal-like male born of incest - The Irish Times

Agalsidase Beta BS IV Infusion [JCR] (JR-051) for Fabry Disease: Notice on the Publication of the Results of the Phase 1 and 2/3 Clinical Trials in…

DetailsCategory: Proteins and PeptidesPublished on Thursday, 18 June 2020 09:51Hits: 112

June 17, 2020 I JCR Pharmaceuticals Co., Ltd. (TSE 4552; Chairman and President: Shin Ashida; JCR) announced today that the results of the phase 1 and 2/3 clinical trials of Agalsidase Beta BS I.V. Infusion [JCR] (JR-051), recombinant Agalsidase Beta, for Fabry disease have been published in the electronic edition of Molecular Genetics and Metabolism, the official journal of Society for Inherited Metabolic Disorders. This is JCRs first product for enzyme replacement therapy (ERT) for Lysosomal Storage Disorders (LSDs), also the first of the kind manufactured in Japan. Agalsidase Beta BS I.V. Infusion [JCR] has been launched since November 2018 as the first biosimilar for the treatment of rare diseases. A summary of the article is as follows.

Title: Pharmacokinetics and pharmacodynamics of JR-051, a biosimilar of agalsidase beta, in healthy adults and patients with Fabry disease: Phase I and II/III clinical studies

Digital Object Identifier: https://doi.org/10.1016/j.ymgme.2020.04.003

Summary The Phase 1 and 2/3 studies were conducted with the aim to verify clinical comparability of JR051 and an upfront biopharmaceutical (agalsidase beta). The results demonstrated that JR051 and agalsidase beta are comparable in terms of efficacy and safety.

Phase 1 study: 20 healthy adult male volunteers were administered JR-051 and agalsidase beta to confirm pharmacokinetic equivalence in a randomized, double-blind, parallel-group manner. The study demonstrated comparable pharmacokinetic profiles of JR-051 and agalsidase beta.

Phase 2/3 study: 16 patients with Fabry disease underwent treatment with agalsidase beta (1mg/kg, once every other week), then were switched to intravenous administrations of JR-051 (1 mg/kg, once every other week).

Efficacy: The 95% confidence intervals of the ratios of the GL-3 plasma concentrations (primary endpoint) during the agalsidase beta treatment, as well as those of Lyso-GL-3, to the respective plasma concentrations after 26 and 52 week-administrations of JR-051 were within pre-determined equivalence acceptability ranges.

Safety: No severe infusion associated reactions (IARs), such as anaphylactic shock, were observed. One IAR, commonly observed with the ERT for Fabry disease, was reported in a patient after JR-051 administration.

[About JCR Pharmaceuticals]

JCR is a specialty pharma company engaged in the research, development, manufacturing and marketing of biopharmaceuticals and regenerative medicine with a focus on rare diseases. Its philosophy, Contributing towards peoples healthcare through pharmaceutical products drives JCR to create innovative pharmaceutical products as value-added treatment options for the under-served patient populations.

SOURCE: JCR Pharmaceuticals

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Agalsidase Beta BS IV Infusion [JCR] (JR-051) for Fabry Disease: Notice on the Publication of the Results of the Phase 1 and 2/3 Clinical Trials in...

Men’s Health Week 2020: From Lung to Bladder, Types of Cancer that Can be More Dangerous in Men Than Women! – LatestLY

Cancer can be a fatal disease, and the exact cause of cancer is still unknown. While many factors could lead to malignant disease, the reason is often based on estimation. The deadly disease affects both men and women alike, but a few types of cancer can be more dangerous in men than women. Genetics, lifestyle habits, and a few other factors make men more predisposed to certain types of cancer. Here are the most common types of cancer in men.

This is a no brainer as only men have the organ and so, women can't suffer from this cancer type. Every man should get a PSA test done after 50 years of age to check if their prostate is healthy. Prostate cancer can be a silent killer, and most often, an individual may not be aware unless one reaches the advanced stage.Mens Health Week 2020: From Cleaning Foot to Keeping Your Armpit Fresh, Here Are Five Personal Hygiene Habits Every Male Should Follow.

Tobacco use is more in men as compared to women which are a prime cause of lung cancer in men. That said, in recent times, there has been a rise in tobacco use in women. However, studies have shown that men are more at risk of lung cancer than women.Mens Health Week 2020: From Prostate Cancer To ED, Common Age-Related Health Problems In Men.

Bladder cancer is more common in men. A study published in the journal General Medicine where data was collected from both men and women who had bladder cancer showed that the male to female ratio was 2.2:1. The findings of the study also showed that the tumours were less aggressive and invasive in women as compared to men.

Did you know that men have a threefold higher risk of developing kidney cancer than women? Smoking, genetics and other occupational factors increase a man's chances of suffering from renal cell carcinoma. Plus, kidney cancer in men are characterised with larger tumours and are more aggressive.

While an equal number of men and women suffer from incidences of acute pancreatitis, chronic pancreatitis is more common in men. While men suffer from alcohol-related pancreatitis, in women, pancreatitis is more due to autoimmune diseases, gall stones and other factors.Men's Health Week 2020: Why Is Male Suicide Rate Higher? Know More About Mental Health Stigma.

Other forms of cancer like mouth and throat cancer and leukaemia are also more common in men than women. Men also tend to suffer from colorectal cancer, so clean eating and corrective lifestyle can save you big time!

(The above story first appeared on LatestLY on Jun 18, 2020 01:41 PM IST. For more news and updates on politics, world, sports, entertainment and lifestyle, log on to our website latestly.com).

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Men's Health Week 2020: From Lung to Bladder, Types of Cancer that Can be More Dangerous in Men Than Women! - LatestLY

China Is Collecting DNA From Tens of Millions of Men and Boys, Using U.S. Gear – The New York Times

The impetus for the campaign can be traced back to a crime spree in the northern Chinese region of Inner Mongolia. For nearly three decades, the police there investigated the rapes and murders of 11 women and girls, one as young as 8. They collected 230,000 fingerprints and sifted through more than 100,000 DNA samples. They offered a $28,000 reward.

Then, in 2016, they arrested a man on unrelated bribery charges, according to the state news media. Analyzing his genes, they found he was related to a person who had left his DNA at the site of the 2005 killing of one of the women. That person, Gao Chengyong, confessed to the crimes and was later executed.

Mr. Gaos capture spurred the state media to call for the creation of a national database of male DNA. The police in Henan Province showed it was possible, after amassing samples from 5.3 million men, or roughly 10 percent of the provinces male population, between 2014 and 2016. In November 2017, the Ministry of Public Security, which controls the police, unveiled plans for a national database.

China already holds the worlds largest trove of genetic material, totaling 80 million profiles, according to state media. But earlier DNA gathering efforts were often more focused. Officials targeted criminal suspects or groups they considered potentially destabilizing, like migrant workers in certain neighborhoods. The police have also gathered DNA from ethnic minority groups like the Uighurs as a way to tighten the Communist Partys control over them.

The effort to compile a national male database broadens those efforts, said Emile Dirks, an author of the report from the Australian institute and a Ph.D. candidate in the department of political science at the University of Toronto. We are seeing the expansion of those models to the rest of China in an aggressive way that I dont think weve seen before, Mr. Dirks said.

In the report released by the Australian institute, it estimated that the authorities aimed to collect DNA samples from 35 million to 70 million men and boys, or roughly 5 percent to 10 percent of Chinas male population. They do not need to sample every male, because one persons DNA sample can unlock the genetic identity of male relatives.

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China Is Collecting DNA From Tens of Millions of Men and Boys, Using U.S. Gear - The New York Times

Mens Health Week 2020: Prostate cancer and other common health problems in Indian men; how to prevent them – Times Now

Mens Health Week 2020: Prostate cancer and other common health problems in Indian men; how to prevent them  |  Photo Credit: iStock Images

New Delhi: Its Men s Health Week, which is observed every year leading up to Fathers Day. The main objective of the week is to raise awareness of health problems that are preventable as well as encourage early detection and treatment of diseases that affect men and boys. Experts say only 30 per cent of a mans overall health is determined by his genetics, and 70 per cent is controllable through his lifestyle. Studies show that men live almost 9 years in poor health in their lifetime - which can be prevented by making small lifestyle changes.

The observance is a reminder for men to take steps for a healthier, longer life - yet, they do not have to do it alone. All of us can help support the health and safety of the men in our lives - whether its your husband, son, dad, brother, or friend. The 2020 Mens Health Week is being observed amid the novel coronavirus pandemic, hence, the theme, Take Action on Covid-19. This year, the week runs from 15-21 June. On the occasion of Mens Health Week, Dr Govardhan Reddy, Lead Consultant - Urology and Uro Oncology, Aster CMI Hospital, Bangalore, talked about the common health problems that affect Indian men and what they can do to prevent them.

Some of the common health issues plaguing Indian men include - prostate cancer, erectile dysfunction, infertility and impotency, heart disease, etc. Apart from this, comorbidities like diabetes, hypertension, obesity, cancer and mental health disorders with daily alcohol intake are some of the largest gender health gaps.

Available evidence indicates that young people are prone to a number of conditions due to personal choices, environmental influences and lifestyle changes. Nutritional disorders (both malnutrition and over-nutrition), tobacco use, harmful alcohol use, other substance use, high-risk sexual behaviors, stress, common mental disorders, and injuries (road traffic injuries, suicides, and violence of different types) specifically affect this population and it has a long-lasting impact.

Talking about prostate cancer, it is advisable for men with a family history ofthe condition to undergo a mandatory screening with the consultant urologist after the age of 45 regardless of any symptoms which comprise of frequent and difficult urination, weak urine stream, blood in semen, pelvic pain or stiffness and erectile dysfunction.

Renal transplant surgeons stress on the use of tobacco as the main cause for cancers in kidney and bladder. Smoking or vaping is also harmful to erectile functions and increases male infertility.

Also, people working in the tar and painting industries or factories carry high risk for bladder cancers. Similarly, fatty diets are known to cause a higher risk for prostate cancer and stone diseases, in order to prevent them it is better to have 2-3 litres of water per day.

Fortunately, many of mens health issues can be prevented or treated if diagnosed early. Here are a few things men can do to prevent or reduce their risk of common health problems:

Making healthier lifestyle choices will not only help prevent or reduce disease risk, but it will also give you an opportunity to enjoy the years of life available to each person.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a professional healthcare provider if you have any specific questions about any medical matter.

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Mens Health Week 2020: Prostate cancer and other common health problems in Indian men; how to prevent them - Times Now

Y chromosome – Genetics Home Reference – NIH

Ginalski K, Rychlewski L, Baker D, Grishin NV. Protein structure prediction for the male-specific region of the human Y chromosome. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2305-10.

Jain M, Olsen HE, Turner DJ, Stoddart D, Bulazel KV, Paten B, Haussler D, Willard HF, Akeson M, Miga KH. Linear assembly of a human centromere on the Y chromosome. Nat Biotechnol. 2018 Mar 19. doi: 10.1038/nbt.4109. [Epub ahead of print]

Krausz C, Casamonti E. Spermatogenic failure and the Y chromosome. Hum Genet. 2017 May;136(5):637-655. doi: 10.1007/s00439-017-1793-8. Epub 2017 Apr 29. Review.

Krausz C, Quintana-Murci L, Forti G. Y chromosome polymorphisms in medicine. Ann Med. 2004;36(8):573-83. Review.

Liu XG, Hu HY, Guo YH, Sun YP. Correlation between Y chromosome microdeletion and male infertility. Genet Mol Res. 2016 Jun 3;15(2). doi: 10.4238/gmr.15028426.

Noordam MJ, Repping S. The human Y chromosome: a masculine chromosome. Curr Opin Genet Dev. 2006 Jun;16(3):225-32. Epub 2006 May 2. Review.

Rizvi AA. 46, XX man with SRY gene translocation: cytogenetic characteristics, clinical features and management. Am J Med Sci. 2008 Apr;335(4):307-9. doi: 10.1097/MAJ.0b013e31811ec1b4.

Russo P, Siani A, Miller MA, Karanam S, Esposito T, Gianfrancesco F, Barba G, Lauria F, Strazzullo P, Cappuccio FP. Genetic variants of Y chromosome are associated with a protective lipid profile in black men. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1569-74. doi: 10.1161/ATVBAHA.108.168641. Epub 2008 May 29.

Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature. 2003 Jun 19;423(6942):825-37.

Tartaglia N, Davis S, Hench A, Nimishakavi S, Beauregard R, Reynolds A, Fenton L, Albrecht L, Ross J, Visootsak J, Hansen R, Hagerman R. A new look at XXYY syndrome: medical and psychological features. Am J Med Genet A. 2008 Jun 15;146A(12):1509-22. doi: 10.1002/ajmg.a.32366.

Visootsak J, Graham JM Jr. Klinefelter syndrome and other sex chromosomal aneuploidies. Orphanet J Rare Dis. 2006 Oct 24;1:42. Review.

Visootsak J, Rosner B, Dykens E, Tartaglia N, Graham JM Jr. Behavioral phenotype of sex chromosome aneuploidies: 48,XXYY, 48,XXXY, and 49,XXXXY. Am J Med Genet A. 2007 Jun 1;143A(11):1198-203.

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Y chromosome - Genetics Home Reference - NIH

Global Male Breast Cancer Market 2020 by Type of Service Offered, Manufacture, Statistics, Share, Growth, Revenue, Regions, and Business Opportunities…

The study on Global Male Breast Cancer Market, offers deep insights about the Male Breast Cancer Market covering all the crucial aspects of theMarket. Some of the important aspects analyzed in the reportincludesMarket share, production, key regions, revenue rate as well as key players. This Male Breast Cancer report also provides the readers with detailed figures at which the Male Breast Cancer Market was valued in the historical year and its expected growth in upcoming years. Besides, analysis also forecasts the CAGR at which the Male Breast Cancer is expected to mount and major factors driving Markets growth. This Male Breast Cancer Market was accounted for USD xxx million in the historical year and isestimated to reach at USD xxx million by the end of the forecast period, rising at a CAGR of xx%.

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Market research reports play anextremely important role in refining the productivity of anindustry. The information in this reports will help the companies to make informed Marketing strategies. Moreover,ultimate goal of Market research is to analyze how the Markets target group will obtain a product or service. Market research report is predominantly prepared following certain methodology and guidelines for collecting, organizing and analyzing data. The research report on Global Male Breast Cancer Market has been very well drafted for the benefit of the readers who are looking forward to invest in the Market. Besides, focusing on overall aspects of the Market this report majorly covered profiles of the top big companies along with their sales data, etc.It also delivers the business models, strategies, growth, innovations and every information about key manufacturers that will enable in making business estimates.

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