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Archive for the ‘Gene Therapy Research’ Category

Research Roundup: How Tau Proteins Spread in Alzheimer’s and More – BioSpace

Every week there are numerous scientific studies published. Heres a look at some of the more interesting ones.

Toxic Tau Proteins Spread in Alzheimers Patients Via Connected Neurons

Two abnormal proteins are associated with Alzheimers disease, beta-amyloid and tau. A study out of Lund University in Sweden and McGill University in Canada showed how toxic tau in the human brain in elderly individuals spreads by way of connected neurons. They also found that beta-amyloid facilitates the spread of toxic tau. The research was published in the journal Nature Communications.

Our research suggests that toxic tau may spread across different brain regions through direct neuronal connections, much like infectious diseases may spread to different cities through different transportation pathways, said lead author Jacob Vogel from McGill. The spread is restricted during normal aging, but in Alzheimers disease the spread may be facilitated by beta-amyloid, and likely leads to widespread neuronal death and eventually dementia.

Beta-amyloid forms plaques in the brain and tau forms tangles within brain cells. Toxic tau, in particular, has been linked to brain degeneration and cognitive symptoms. In general, beta-amyloid appears earlier in the disease with tau appearing later.

Our findings have implications for understanding the disease, but more importantly for the development of therapies against Alzheimers, which are directed against either beta-amyloid or tau, said Oskar Hansson, co-lead investigator of the study and professor of neurology at Lund. Specifically, the results suggest that therapies that limit uptake of tau into the neurons or transportation or excretion of tau, could limit disease progression.

Improving on Gene Therapy by Decreasing Immune Response to AAV

Biotech company Spark Therapeutics published research in the journal Nature Medicine showing that treatment with immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS0 caused fast and transient decrease of neutralizing anti-adeno-associated virus (AAV) antibodies and restored gene therapy efficacy in laboratory animals. The study was conducted by Spark, Genethon, the Centre de Recherche des Cordeliers (Inserm, Sorbonne Universite, Universite de Paris) and the National Centre for Scientific Research (CNRS) in France.

Biggest Risk Factors for Severe COVID-19 in UK

In a large cohort study published in The BMJ of COVID-19 patients in the UK, the biggest risk factors for severe disease or death were found to be age over 50, being male, obese, or having underlying heart, lung, liver and kidney disease. The study, which is still ongoing, recruited over 43,000 patients. The study essentially looked at data from a third of all COVID-19 patients admitted to hospitals in the UK between February 6 and April 19, 2020. Overall, the data confirms studies conducted in China, although obesity was not highlighted in the China data. The researchers believe that reduced lung function or obesity-related inflammation are the factors involved in increased disease severity or mortality in obese patients.

Warmer Temperatures Slow COVID-19A Little Bit

Researchers at Mount Auburn Hospital evaluated the impact of temperature, precipitation and UV index on COVID-19 cases in the U.S. during the spring of 2020. They found that while the rate of COVID-19 incidence decreases with warmer temperatures up to 52 degrees F, anything warmer than that does not decrease disease transmission all that much. Precipitation doesnt seem to have any effect and UV index helps a little bit. The bottom line, they say, is that their research supports what the Centers for Disease Control and Prevention (CDC) is saying, which is that although the pandemic might abate a little bit in the summer, it is expected to be worse in the fall and winter.

Antibodies Against Alzheimers Toxic Particles

Investigators at the University of Cambridge have identified a method to design an antibody that can seek out and attack the toxic particles that destroy healthy brain cells, such as in Alzheimers disease. These antibodies recognize amyloid-beta oligomers. They believe this could lead to new diagnostics or possible treatments for Alzheimers and other types of dementia.

Oligomers are difficult to detect, isolate, and study, said Francesco Aprile, the studys lead author. Our method allows the generation of antibody molecules able to target oligomers despite their heterogeneity, and we hope it could be a significant step towards new diagnostic approaches.

Physical Distancing, Masks and Eye Protection Help Prevent COVID-19

As has been suggested all along, the use of physical distancing, face masks and eye protection does appear, in a systematic review of the literature by researchers at McMaster University, to help prevent the transmission of COVID-19. The two meters (about six feet) physical distancing seems to prevent person-to-person transmission and face masks and eye protect decrease the risk of infection.

Although the direct evidence is limited, the use of masks in the community provides protection, and possibly N95 or similar respirators worn by health care workers suggest greater protection than other face masks, said Holger Schunemann, professor of the departments of health research methods, evidence, and impact, and medicine at McMaster. Availability and feasibility and other contextual factors will probably influence recommendations that organizations develop about their use. Eye protection may provide additional benefits.

The review was led by McMaster researchers, but also included a large, international collaboration of researchers, front-line and specialist clinicians, epidemiologists, patients, public health and health policy experts of published and unpublished studies in any language. They also evaluated direct evidence on COVID-19 and indirect evidence on other coronaviruses, such as the ones that cause SARS and MERS. Although there were no randomized control trials addressing the three coronaviruses (SARS, MERS and COVID-19), they found 44 relevant comparative studies in health care and community settings across 16 countries and six continents from inception to early May 2020. The study was published in The Lancet.

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Research Roundup: How Tau Proteins Spread in Alzheimer's and More - BioSpace

Groundbreaking Gene Therapies for Hereditary Diseases / Alessandro Aiuti, a physician and research scientist from Milan, receives the Else Krner…

The current coronavirus pandemic clearly illustrates how dangerous viral infections can become for us. Independent of the present situation, there are people whose bodies are defenseless against infections because their immune systems are unable to combat them - they suffer from immunodeficiency diseases such as ADA-SCID (adenosine deaminase severe combined immunodeficiency) or Wiskott-Aldrich syndrome. Prof. Dr. Alessandro Aiuti, a physician and research scientist based in Milan who works at the San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget) and at the Vita Salute San Raffaele University, is now being honored with the Else Krner Fresenius Prize for Medical Research 2020 for his groundbreaking successes in the development of gene therapies. The award is coupled to 2.5 million euros in prize money.

In the case of the rare immune disorder ADA-SCID, which exclusively afflicts young children and occurs about 15 times a year in Europe, a defective ADA gene within the genome disrupts lymphocyte development, leaving the young patient's body defenseless against infections. "Without effective therapy, the children rarely survive for more than 2 years because any infection can become perilous for them," Aiuti explains. Standard for this therapy is a bone marrow transplantation from a fully matched sibling. However, a suitable donor is available only for a minority of patients. "Meanwhile children with such a condition benefit from the advances we have made in the field of gene therapy. So far we have treated 36 children from 19 countries using the therapy we developed. In more than 80 percent of the cases, the treatment has had such an impact that no enzyme replacement therapy or transplantation is needed. This achievement has been made possible by the extraordinary effort and dedication of SR-Tiget researchers and clinical team throughout 25 years," Aiuti adds. All of the patients are still alive.

For these successes and his other work in the field of gene therapy, Alessandro Aiuti has now been honored with the Else Krner Fresenius Prize for Medical Research 2020 awarded by the Else Krner-Fresenius-Stiftung (EKFS) foundation. At 2.5 million euros, this award is one of the highest endowed prizes for medical research in the world. "Still young by comparison, this year the prize is being awarded for the third time. It honors research scientists for pioneering contributions in the areas of biomedical science. A major percentage of the prize money flows into the prizewinner's research and is supposed to contribute toward achieving further groundbreaking findings and medical breakthroughs in the future as well," emphasizes Prof. Dr. Michael Madeja, scientific director and member of the management board at EKFS.

The decision regarding the prize recipient was made by a ten-member international jury composed of renowned research scientists in the fields of genome editing and gene therapy along with delegates from the Scientific Commission at EKFS. Prof. Dr. Hildegard Bning, chairwoman of the jury and president of the European Society for Gene and Cell Therapy (ESGCT), substantiates the jury's decision: "Alessandro Aiuti is a truly outstanding physician and scientist. His work has decisively contributed to the development and successful treatment of rare, genetically caused disorders such as SCID. Thanks not least of all to the contributions he has made, even patients with other inheritable illnesses can presumably be treated successfully in the future."

After successful clinical trials, the gene therapy developed for ADA-SCID patients was approved as a pharmaceutical remedy in Europe. It is considered to be one of the key findings in the development of gene therapies worldwide. With this treatment certain blood stem cells (CD34+) are taken from the patient, then the cell DNA is modified. The cells are treated outside the body using a viral vector to accomplish this. The correct version of the gene for the ADA enzyme is introduced into the genome of the cells that were collected. The genetically modified cells are returned to the patient's bloodstream via intravenous infusion. A portion of the modified cells subsequently establish themselves in bone marrow again. The patient now has blood stem cells that function properly and produce lymphocytes to defend against infections - presumably on a life-long basis.

Alessandro Aiuti wants to utilize the prize money from EKFS to set the success story forth, to optimize the therapies further and map out the healing mechanisms involved in a better fashion. The scientist sees another major challenge in conveying the acquired knowledge beyond the successful gene therapies from Milan to as many other genetic disorders as possible. Alongside the therapy for ADA-SCID, the San Raffaele Telethon Institute for Gene Therapy has also developed gene therapies for four more hereditary diseases, among them the Wiskott-Aldrich syndrome and metachromatic leukodystrophy (MLD). To this day a total of more than 100 patients from 35 different countries have been treated.

Biography of Alessandro Aiuti

Alessandro Aiuti was born in Rome in 1966 and studied medicine there at Sapienza University. Following a stay at Harvard Medical School in Boston, Massachusetts in the USA, he received his doctorate in Human Biology in 1996 from Sapienza University. Since 1997 he has been active at the San Raffaele Scientific Institute in Milan, where he meanwhile also teaches as a professor at the Vita Salute San Raffaele University. He is furthermore Deputy Director of Clinical Research at the San Raffaele Telethon Institute for Gene Therapy and Head of the Pediatric Immunohematology Unit at San Raffaele Hospital.

Aiuti is the author of numerous and highly acclaimed publications. Over the course of his career he has received a number of prizes from national and international institutions. Aiuti is a member of the board of the European Society of Gene and Cell Therapy, and a member of the EMA Committee for Advanced Therapies since 2019.

The Else Krner Fresenius Prize for Medical Research

The international Else Krner Fresenius Prize for Medical Research came into existence in 2013 on the occasion of the 25th anniversary of Else Krner's death and is awarded in alternating fields of biomedical science. Endowed with 2.5 million euros, the prize is one of the most highly endowed medical research awards in the world. It honors and supports research scientists who have made significant scientific contributions in their fields and whose work can be expected to yield groundbreaking findings and medical breakthroughs in the future as well.

The Else Krner-Fresenius-Stiftung (EKFS) foundation - Advancing research. Helping people.

The Else Krner-Fresenius-Stiftung, a non-profit foundation, is dedicated to the funding of medical research and supports medical/humanitarian projects. The foundation was established in 1983 by entrepreneur Else Krner and appointed as her sole heir. EKFS receives virtually all of its income in dividends from the Fresenius healthcare group, in which the foundation is the majority shareholder. To date, the foundation has funded around 2,000 projects. With a current annual funding volume around 60 million euros the EKFS is one of the largest foundations for medicine in Germany. More information:www.ekfs.de.

The San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget)

Based in Milan, Italy, the San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget) is a joint venture between the Ospedale San Raffaele and Fondazione Telethon. SR-Tiget was established in 1995 to perform research on gene transfer and cell transplantation and translate its results into clinical applications of gene and cell therapies for different genetic diseases. Over the years, the Institute has given a pioneering contribution to the field with relevant discoveries in vector design, gene transfer strategies, stem cell biology, identity and mechanism of action of innate immune cells. SR-Tiget has also established the resources and framework for translating these advances into novel experimental therapies and has implemented several successful gene therapy clinical trials for inherited immunodeficiencies, blood and storage disorders, which have already treated >115 patients and have led through collaboration with industrial partners to the filing and approval of novel advanced gene therapy medicines.

Fondazione Telethon

Fondazione Telethon is a non-profit organisation created in 1990 as a response to the appeals of a patient association group of stakeholders, who saw scientific research as the only real opportunity to effectively fight genetic diseases. Thanks to the funds raised through the television marathon, along with other initiatives and a network of partners and volunteers, Telethon finances the best scientific research on rare genetic diseases, evaluated and selected by independent internationally renowned experts, with the ultimate objective of making the treatments developed available to everyone who needs them. Throughout its 30 years of activity, Fondazione Telethon has invested more than EUR 528 million in funding more than 2.630 projects to study more than 570 diseases, involving over 1.600 scientists. Fondazione Telethon has made a significant contribution to the worldwide advancement of knowledge regarding rare genetic diseases and of academic research and drug development with a view to developing treatments. For more information, please visit:www.telethon.it

Issued by news aktuell/ots on behalf of Else Krner-Fresenius-Stiftung

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Groundbreaking Gene Therapies for Hereditary Diseases / Alessandro Aiuti, a physician and research scientist from Milan, receives the Else Krner...

CSL Behring and Seattle Children’s Research Institute to Advance Gene Therapy Treatments for Primary Immunodeficiency Diseases – The Delaware County…

SEATTLE and KING of PRUSSIA, Pa., June 2, 2020 /PRNewswire/ --Seattle Children's Research Institute, one of the top pediatric research institutions in the world, and global biotechnology leader CSL Behring announced a strategic alliance to develop stem cell gene therapies for primary immunodeficiency diseases.

Initially, the alliance will focus on the development of treatment options for patients with two rare, life-threatening primary immunodeficiency diseases -- Wiskott-Aldrich Syndrome and X-linked Agammaglobulinemia. These are two of more than 400 identified primary immunodeficiency diseases in which a part of the body's immune system is missing or functions improperly.

"CSL Behring will collaborate with Seattle Children's experts to apply our novel gene therapy technology to their research pipeline, with an aim to address unmet needs for people living with certain rare primary immunodeficiency diseases," said Bill Mezzanotte, MD, Executive Vice President, Head of Research and Development for CSL Behring. "Expanding our gene therapy portfolio into an area of immunology well known to CSL exemplifies how we are strategically growing our capabilities in this strategic scientific platform and are collaborating with world class institutions to access innovation with the potential to vastly improve patients' lives."

"Stem cell gene therapies that correct the genetic abnormality driving a child's disease will transform the therapeutic options for children with Wiskott-Aldrich Syndrome, X-Linked Agammaglobulinemia and other immunodeficiency diseases,"said David J. Rawlings, MD, director of the Center for Immunity and Immunotherapies and division chief of immunology at Seattle Children's, and a professor of pediatrics and immunology at the University of Washington School of Medicine."The collaboration with CSL Behring supports our longstanding research programs for pediatric immunodeficiency diseases and will accelerate this research toward clinical trials, helping get these innovations to the children who need them."

CSL Behring researchers, working with researchers from Seattle Children's Research Institute, will investigate applying the proprietary platform technologies, Select+ and Cytegrity, to several pre-clinical gene therapy programs. These technologies, which have broad applications in ex vivo stem cell gene therapy, are designed to address some of the major challenges associated with the commercialization of stem cell therapy, including the ability to manufacture consistent, high-quality products, and to improve engraftment, efficacy and tolerability.

Wiskott-Aldrich Syndrome (WAS) has an estimated incidence between one and 10 cases per million males worldwide, according to the National Institutes of Health. WAS patients' immune systems function abnormally, making them susceptible to infections. They also experience eczema, autoimmunity and difficulty forming blood clots, leaving them vulnerable to life threatening bleeding complications. Today the only knowncurefor WAS is a stem cell transplant, if a suitable donor can be found.

X-linked Agammaglobulinemia (XLA) is another rare primary immunodeficiency in which patients have low levels of immunoglobulins (also known as antibodies), which are key proteins made by the immune system to help fight infections. Like WAS, XLA affects males almost exclusively, although females can be genetic carriers of the condition. While no cure exists for XLA, the goal of treatment is to boost the immune system by replacing missing antibodies and preventing or aggressively treating infections that occur, according to the Immune Deficiency Foundation.

About Seattle Children's

Seattle Children's mission is to provide hope, care and cures to help every child live the healthiest and most fulfilling life possible. Together, Seattle Children's Hospital, Research Institute and Foundation deliver superior patient care, identify new discoveries and treatments through pediatric research, and raise funds to create better futures for patients.

Ranked as one of the top children's hospitals in the country by U.S. News & World Report, Seattle Children's serves as the pediatric and adolescent academic medical center for Washington, Alaska, Montana and Idaho the largest region of any children's hospital in the country. As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is internationally recognized for its work in neurosciences, immunology, cancer, infectious disease, injury prevention and much more. Seattle Children's Hospital and Research Foundation works with the Seattle Children's Guild Association, the largest all-volunteer fundraising network for any hospital in the country, to gather community support and raise funds for uncompensated care and research. Join Seattle Children's bold initiative It Starts With Yes: The Campaign for Seattle Children's to transform children's health for generations to come.

For more information, visit seattlechildrens.org or follow us on Twitter, Facebook, Instagram or on our On the Pulse blog.

About CSL Behring

CSL Behring is a global biotherapeutics leader driven by its promise to save lives. Focused on serving patients' needs by using the latest technologies, we develop and deliver innovative therapies that are used to treat coagulation disorders, primary immune deficiencies, hereditary angioedema, inherited respiratory disease, and neurological disorders. The company's products are also used in cardiac surgery, burn treatment and to prevent hemolytic disease of the newborn. CSL Behring operates one of the world's largest plasma collection networks, CSL Plasma. The parent company, CSL Limited (ASX:CSL;USOTC:CSLLY), headquartered in Melbourne, Australia, employs more than 26,000 people, and delivers its life-saving therapies to people in more than 70 countries. For more information, visit http://www.cslbehring.com and for inspiring stories about the promise of biotechnology, visit Vita http://www.cslbehring.com/Vita.

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CSL Behring and Seattle Children's Research Institute to Advance Gene Therapy Treatments for Primary Immunodeficiency Diseases - The Delaware County...

How COVID-19 is Affecting Clinical Trials and Drug Supplies from Biotech Bay Companies – BioSpace

Much of the news has been focused on the novel coronavirus and the rush to develop vaccines and treatments for the disease it causes (called COVID-19). But what is happening with all the other companies not directly involved in COVID-19 research? And how is COVID-19 affecting their clinical trials and drug supplies?

To answer these questions, BioSpace looked at COVID-19s impact on each of the Hotbeds.

Biotech Bay, the bustling biotech industry around San Francisco in California, is home to lots of biopharma companies, many of whom are trying to keep business as close to usual while adapting to these unique times.

Check out the table below for the impacts that Biotech Bay companies are experiencing due to COVID-19.

(For information about what Biotech Bay companies have joined the fight against COVID-19 and how they are working towards vaccines and treatments, check out this article.)

The information in this table was up to date as of May 18, 2020.

4D Molecular Therapeutics

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Allakos, Inc.

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Ambys Medicines

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Apollomics, Inc.

Disease Focus:

Clinical Trial Impacts of COVID-19:

Arcus Biosciences

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Assembly Biosciences

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

BioMarin Pharmaceutical Inc.

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

BridgeBio

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

DNA Script

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Eurofins DiscoverX

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Exelixis, Inc.

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

FibroGen

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Global Blood Therapeutics

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Horizon Therapeutics

Disease Focus:

Clinical Trial Impacts of COVID-19:

Drug Supply Impacts of COVID-19:

Intabio

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Iovance Biotherapeutics

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JOINN Biologics

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Maze Therapeutics

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MyoKardia

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How COVID-19 is Affecting Clinical Trials and Drug Supplies from Biotech Bay Companies - BioSpace

Strategic Analysis to Understand the Competitive Outlook of Gene Therapy Market – Cole of Duty

Prophecy Market Insights Gene Therapy market research report provides a comprehensive, 360-degree analysis of the targeted market which helps stakeholders to identify the opportunities as well as challenges. The research report study offers keen competitive landscape analysis including key development trends, accurate quantitative and in-depth commentary insights, market dynamics, and key regional development status forecast 2020-2029. It incorporates market evolution study, involving the current scenario, growth rate, and capacity inflation prospects, based on Porters Five Forces and DROT analyses.

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An executive summary provides the markets definition, application, overview, classifications, product specifications, manufacturing processes; raw materials, and cost structures.

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Segment Level Analysis in terms of types, product, geography, demography, etc. along with market size forecast

Regional and Country- level Analysis different geographical areas are studied deeply and an economical scenario has been offered to support new entrants, leading market players, and investors to regulate emerging economies. The top producers and consumers focus on production, product capacity, value, consumption, growth opportunity, and market share in these key regions, covering

The comprehensive list of Key Market Players along with their market overview, product protocol, key highlights, key financial issues, SWOT analysis, and business strategies. The report dedicatedly offers helpful solutions for players to increase their clients on a global scale and expand their favour significantly over the forecast period. The report also serves strategic decision-making solutions for the clients.

Competitive landscape Analysis provides mergers and acquisitions, collaborations along with new product launches, heat map analysis, and market presence and specificity analysis.

Segmentation Overview:

Gene TherapyMarket Key Companies:

GlaxoSmithKline plc, Bluebird Bio, Inc., Adaptimmune Therapeutics plc, Celgene Corporation, Shanghai Sunway Biotech Co. Ltd., Merck KGaA, Transgene SA, and OncoGenex Pharmaceuticals, Inc.

The Gene Therapy research study comprises 100+ market data Tables, Graphs & Figures, Pie Chat to understand detailed analysis of the market. The predictions estimated in the market report have been resulted in using proven research techniques, methodologies, and assumptions. This Gene Therapy market report states the market overview, historical data along with size, growth, share, demand, and revenue of the global industry.

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The study analyses the manufacturing and processing requirements, project funding, project cost, project economics, profit margins, predicted returns on investment, etc. This report is a must-read for investors, entrepreneurs, consultants, researchers, business strategists, and all those who have any kind of stake or are planning to foray into the Gene Therapy industry in any manner.

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Strategic Analysis to Understand the Competitive Outlook of Gene Therapy Market - Cole of Duty

Size & Share of Cell and Gene Therapy Consumables Market 2020 Research Report and Forecast to 2026 – Surfacing Magazine

Facts & Factors (FnF),a leading market research company recently published a research report on Cell and Gene Therapy Consumables Market By Product Type (Kits & Buffers, Diagnostic Assay, Culture Medium, and Cryopreservation Media) and By Application/ Therapeutics (Cardiovascular, Urology, Dermatology, Critical Care, Respiratory, Endocrine & Metabolic, Neuroscience, Hematology & Oncology, Obstetrics, Immunology, and Gastroenterology): Global Industry Perspective, Comprehensive Analysis, and Forecast, 2018 2027 to its research database. This Cell and Gene Therapy Consumables Market report analyses the comprehensive overview of the market comprising an executive summary that covers core trends evolving in the market.

TheCell and Gene Therapy Consumables marketreport aims to enumerate market size and trends, which is accompanied and put in plain words with qualitative data. The Cell and Gene Therapy Consumables industry segmentation is carefully analyzed with an observation stage analyzing and the present and past situations. Considering the facts, the likely future situations and estimates for the future are developed. The cultural diversity has always been the main concern for any business. So, we have illustrated this through geographical analysis which makes it easy to understand the revenue flow through each region.

Some of Top Market Players Analysis Included in this Report:

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The Cell and Gene Therapy Consumables industry report offers the analyzed data by bifurcating the Cell and Gene Therapy Consumables market on the basis of form and type of product or service, processing technology involved applications of the end-product, and others, including the geographical categorization of the market. The Cell and Gene Therapy Consumables market report also provides detailed information regarding specific business and financial terms, market strategies, expected market growth, and much more.

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The report study further includes an in-depth analysis of industry players market shares and provides an overview of leading players market position in the Cell and Gene Therapy Consumables sector. Key strategic developments in the Cell and Gene Therapy Consumables market competitive landscape such as acquisitions & mergers, inaugurations of different products and services, partnerships & joint ventures, MoU agreements, VC & funding activities, R&D activities, and geographic expansion among other noteworthy activities by key players of the Cell and Gene Therapy Consumables market are appropriately highlighted in the report.

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The Cell and Gene Therapy Consumables market report aims to enumerate market size and trends, which is accompanied and put in plain words with qualitative data. The Cell and Gene Therapy Consumables industry segmentation is carefully analyzed with an observation stage analyzing and the present and past situations. Considering the facts, the likely future situations and estimates for the future are developed. The cultural diversity has always been the main concern for any business. So, we have illustrated this through geographical analysis which makes it easy to understand the revenue flow through each region.

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3. To provide historically and forecast revenue of the Cell and Gene Therapy Consumables market segments and sub-segments with respect to four main geographies and their countries- North America, Europe, Asia, and the Rest of the World.

4. Country-level analysis of the market with respect to the current market size and future prospective.

5. To provide country-level analysis of the market for segment by application, product type, and sub-segments.

6. To provide strategic profiling of key players in the market, comprehensively analyzing their core competencies, and drawing a competitive landscape for the market.

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The regional segmentation of the Cell and Gene Therapy Consumables market is done as follows:

Competitive Landscape and Cell and Gene Therapy Consumables Market Share Analysis

Cell and Gene Therapy Consumables competitive landscape provides details by vendors, including company overview, company total revenue (financials), market potential, global presence, Cell and Gene Therapy Consumables sales and revenue generated, market share, price, production sites and facilities, SWOT analysis, product launch. For the period 2019-2027, this study provides the Cell and Gene Therapy Consumables sales, revenue, and market share for each player covered in this report.

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Size & Share of Cell and Gene Therapy Consumables Market 2020 Research Report and Forecast to 2026 - Surfacing Magazine

The bioreactors market was valued at US$ 2,958.50 million in 2019 and is projected to reach US$ 5,169.01 million by 2027; it is expected to grow at a…

New York, June 05, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Bioreactors Market Forecast to 2027 - COVID-19 Impact and Global Analysis by Cell ; Molecule ; Technology ; End User, and Geography" - https://www.reportlinker.com/p05908638/?utm_source=GNW

A bioreactor is equipment or system engineered to provide biologically active environment for the production of various medical and pharmaceutical compounds.The vessel is used to carry out a chemical process, which involves organisms or biochemically active substances derived from such organisms.

This process can either be aerobic or anaerobic.The bioreactors are commonly cylindrical, ranging in size from liters to cubic meters, and are generally made of stainless steel.

Bioreactors provide a controllable environment, in terms of pH, temperature, nutrient supply, and shear stress for any cells.The use of single-use bioreactors has increased in the modern biopharmaceutical processes in the last few years.This can be attributed to their unique ability to allow enhanced process flexibility, reduce investment requirements, and limit operational costs.

Also, many companies have developed single-use bioreactors for the production of a wide range of therapeutics. For instance, Distek Inc., has developed a benchtop single-use bioreactor system for recombinant protein production. Single-use bioreactors reduce the risks of contamination and decrease production turnaround times. Moreover, the reduction in validation time has been one of the prime benefits of single-use bioreactors. The rising adoption of single-use bioreactors for upstream bioprocessing is driving the growth of the market. For instance, Sartorius AG offers a wide range of single-use bioreactors. The company provides ambr 15 for a 10-15 mL microbioreactor scale and Biostat STR for 50-2000 L.The global bioreactors market is segmented on the basis of cell, molecule, technology, and end user.The bioreactors market, by molecule, is segmented into monoclonal antibodies, vaccines, recombinant proteins, stem cells, gene therapy, and others.

The monoclonal antibodies segment held the largest share of the market in 2019.However, the stem cell segment is projected to register the highest CAGR in the market during the forecast period.

Based on cell, the bioreactors market is segmented into mammalian cells, bacterial cells, yeast cells, and others.Based on technology, the market is segmented into wave-induced motion sub, stirred sub, single-use bubble column, and others.

Based on end user, the market is segmented into research and development organizations, biopharma manufacturers, contract manufacturing organizations (CMOs).A few of the essential primary and secondary sources referred to while preparing the report are the Food and Drug Administration (FDA), World Health Organization (WHO), Organization for Economic Co-operation and Development, National Institutes of Health (NIH), and Centers for Disease Control and Prevention (CDC), among others.Bioreactors Market Forecast to 2027 - Covid-19 Impact and Global Analysis by Cell, Molecule, Technology, End User, and GeographyThe bioreactors market was valued at US$ 2,958.50 million in 2019 and is projected to reach US$ 5,169.01 million by 2027; it is expected to grow at a CAGR of 7.3% from 2020 to 2027. A bioreactor is equipment or system engineered to provide biologically active environment for the production of various medical and pharmaceutical compounds.The vessel is used to carry out a chemical process, which involves organisms or biochemically active substances derived from such organisms.

This process can either be aerobic or anaerobic.The bioreactors are commonly cylindrical, ranging in size from liters to cubic meters, and are generally made of stainless steel.

Bioreactors provide a controllable environment, in terms of pH, temperature, nutrient supply, and shear stress for any cells.The use of single-use bioreactors has increased in the modern biopharmaceutical processes in the last few years.This can be attributed to their unique ability to allow enhanced process flexibility, reduce investment requirements, and limit operational costs.

Also, many companies have developed single-use bioreactors for the production of a wide range of therapeutics. For instance, Distek Inc., has developed a benchtop single-use bioreactor system for recombinant protein production. Single-use bioreactors reduce the risks of contamination and decrease production turnaround times. Moreover, the reduction in validation time has been one of the prime benefits of single-use bioreactors. The rising adoption of single-use bioreactors for upstream bioprocessing is driving the growth of the market. For instance, Sartorius AG offers a wide range of single-use bioreactors. The company provides ambr 15 for a 10-15 mL microbioreactor scale and Biostat STR for 50-2000 L.The global bioreactors market is segmented on the basis of cell, molecule, technology, and end user.The bioreactors market, by molecule, is segmented into monoclonal antibodies, vaccines, recombinant proteins, stem cells, gene therapy, and others.

The monoclonal antibodies segment held the largest share of the market in 2019.However, the stem cell segment is projected to register the highest CAGR in the market during the forecast period.

Based on cell, the bioreactors market is segmented into mammalian cells, bacterial cells, yeast cells, and others.Based on technology, the market is segmented into wave-induced motion sub, stirred sub, single-use bubble column, and others.

Based on end user, the market is segmented into research and development organizations, biopharma manufacturers, contract manufacturing organizations (CMOs).A few of the essential primary and secondary sources referred to while preparing the report are the Food and Drug Administration (FDA), World Health Organization (WHO), Organization for Economic Co-operation and Development, National Institutes of Health (NIH), and Centers for Disease Control and Prevention (CDC), among others.Read the full report: https://www.reportlinker.com/p05908638/?utm_source=GNW

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The bioreactors market was valued at US$ 2,958.50 million in 2019 and is projected to reach US$ 5,169.01 million by 2027; it is expected to grow at a...

Cancer Gene Therapy Market Incredible Possibilities, Growth With Industry Study, Detailed Analysis And Forecast To 2025 – Bulletin Line

UpMarketResearch report titled Global Cancer Gene Therapy Market provides detailed information and overview about the key influential factors required to make well informed business decision. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. Our data has been culled out by our team of experts who have curated the report, considering market-relevant information. This report provides latest insights about the markets drivers, restraints, opportunities, and trends. It also discusses the growth and trends of various segments and the market in various regions.

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Cancer Gene Therapy Market Report Includes:

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By Product Types:Insertion of new genes into the bodyOther

The report is further broken down into various segments such as product types, applications, and regions.

By Applications:HospitalsDiagnostic CentresDrug ManufacturersResearch Institutes

Our analysts drafted the report by gathering information through primary (through surveys and interviews) and secondary (included industry body databases, reputable paid sources, and trade journals) methods of data collection. The report encompasses an exhaustive qualitative and quantitative evaluation.

The study includes growth trends, micro- and macro-economic indicators, and regulations and governmental policies.

By Regions:Asia Pacific (China, Japan, India, and Rest of Asia Pacific)Europe (Germany, the UK, France, and Rest of Europe)North America (the US, Mexico, and Canada)Latin America (Brazil and Rest of Latin America)Middle East & Africa (GCC Countries and Rest of Middle East & Africa)

The Cancer Gene Therapy Market Report Covers the Following Companies:Cell GenesysAdvantageneGenVecBioCancellCelgene and Epeius BiotechnologiesIntrogen TherapeuticsZIOPHARM OncologyMultiVirShenzhen SiBiono GeneTech

The subject matter experts analyzed various companies to understand the products and/services relevant to the market. The report includes information such as gross revenue, production and consumption, average product price, and market shares of key players. Other factors such as competitive analysis and trends, mergers & acquisitions, and expansion strategies have been included in the report. This will enable the existing competitors and new entrants understand the competitive scenario to plan future strategies.

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About UpMarketResearch:UpMarketResearch (https://www.upmarketresearch.com) is a leading distributor of market research report with more than 800+ global clients. As a market research company, we take pride in equipping our clients with insights and data that holds the power to truly make a difference to their business. Our mission is singular and well-defined we want to help our clients envisage their business environment so that they are able to make informed, strategic and therefore successful decisions for themselves.Contact Info UpMarketResearchName Alex MathewsEmail [emailprotected]Website https://www.upmarketresearch.comAddress 500 East E Street, Ontario, CA 91764, United States.

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Cancer Gene Therapy Market Incredible Possibilities, Growth With Industry Study, Detailed Analysis And Forecast To 2025 - Bulletin Line

Gene Therapy for Age-related Macular Degeneration Market 2020: Potential growth, attractive valuation make it is a long-term investment | Know the…

Global Gene Therapy for Age-related Macular Degeneration Market Report is a professional and in-depth research report on the worlds major regional market. The Gene Therapy for Age-related Macular Degeneration industry2020 by Industry Demand, Business Strategy & Emerging Trends by Leading Players. The Global pandemic of COVID19/CORONA Virus calls for redefining of business strategies. This Gene Therapy for Age-related Macular Degeneration Market report includes the impact analysis necessary for the same.

Download the Sample ToC to understand the CORONA Virus/COVID19 impact and be smart in redefining business strategies. https://inforgrowth.com/CovidImpact-Request/6321856/gene-therapy-for-age-related-macular-degeneration-

Top Players Listed in the Gene Therapy for Age-related Macular Degeneration Market Report areRetroSense Therapeutics, REGENXBIO, AGTC, .

Gene Therapy for Age-related Macular Degenerationmarket report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, the impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

Market Segmentations: Global Gene Therapy for Age-related Macular Degeneration market competition by top manufacturers, with production, price, revenue (value) and market share for each manufacturer.

Based on type, report split into Subretinal, Intravitreal, Unspecified.

Based on the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate for each application, including Monotherapy, Combination Therapy.

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The report introduces Gene Therapy for Age-related Macular Degeneration basic information including definition, classification, application, industry chain structure, industry overview, policy analysis, and news analysis. Insightful predictions for the Gene Therapy for Age-related Macular Degeneration Market for the coming few years have also been included in the report.

In the end, Gene Therapy for Age-related Macular Degenerationreport provides details of competitive developments such as expansions, agreements, new product launches, and acquisitions in the market for forecasting, regional demand, and supply factor, investment, market dynamics including technical scenario, consumer behavior, and end-use industry trends and dynamics, capacity, spending were taken into consideration.

Important Key questions answered in Gene Therapy for Age-related Macular Degenerationmarket report:

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Gene Therapy for Age-related Macular Degeneration Market 2020: Potential growth, attractive valuation make it is a long-term investment | Know the...

Gene Therapy Market to Reach $4402 million by 2023 with Key Players Novartis, Kite Pharma, GlaxoSmithKline, Spark Therapeutics – Cole of Duty

The global gene therapy market was valued at $584 million in 2016, and is estimated to reach $4,402 million by 2023, registering a CAGR of 33.3% from 2017 to 2023. Gene therapy is a technique that involves the delivery of nucleic acid polymers into a patients cells as a drug to treat diseases. It fixes a genetic problem at its source. The process involves modifying the protein either to change the genetic expression or to correct a mutation. The emergence of this technology meets the rise in needs for better diagnostics and targeted therapy tools. For instance, genetic engineering can be used to modify physical appearance, metabolism, physical capabilities, and mental abilities such as memory and intelligence. In addition, it is also used for infertility treatment. Gene therapy offers a ray of hope for patients, who either have no treatment options or show no benefits with drugs currently available. The ongoing success has strongly supported upcoming researches and has carved ways for enhancement of gene therapy.

Top Companies Covered in this Report:, Novartis, Kite Pharma, Inc., GlaxoSmithKline PLC, Spark Therapeutics Inc., Bluebird bio Inc., Genethon, Transgene SA, Applied Genetic Technologies Corporation, Oxford BioMedica, NewLink Genetics Corp.

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The gene therapy market is a widely expanding field in the pharmaceutical industry with new opportunities. This has piqued the interests of venture capitalists to explore this market and its commercial potential. Major factors that drive the growth of this market include high demands for DNA vaccines to treat genetic diseases, targeted drug delivery, and high incidence of genetic disorders. However, the stringent regulatory approval process for gene therapy and the high costs of gene therapy drugs are expected to hinder the growth of the market.

The global gene therapy market is segmented based on vector type, gene type, application, and geography. Based on vector type, it is categorized into viral vector and non-viral vector. Viral vector is further segmented into retroviruses, lentiviruses, adenoviruses, adeno associated virus, herpes simplex virus, poxvirus, vaccinia virus, and others. Non-viral vector is further categorized into naked/plasmid vectors, gene gun, electroporation, lipofection, and others. Based on gene type, the market is classified into antigen, cytokine, tumor suppressor, suicide, deficiency, growth factors, receptors, and others. Based on application, the market is divided into oncological disorders, rare diseases, cardiovascular diseases, neurological disorders, infectious disease, and other diseases. Based on region, it is analyzed across North America, Europe, Asia-Pacific, and LAMEA.

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Table Of Content

CHAPTER 1: INTRODUCTION

CHAPTER 2: EXECUTIVE SUMMARY

CHAPTER 3: MARKET OVERVIEW

CHAPTER 4: GENE THERAPY MARKET, BY VECTOR TYPE

CHAPTER 5: GENE THERAPY MARKET, BY GENE TYPE

CHAPTER 6: GENE THERAPY MARKET, BY APPLICATION

CHAPTER 7: GENE THERAPY MARKET, BY REGION

CHAPTER 8: COMPANY PROFILE

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Gene Therapy Market to Reach $4402 million by 2023 with Key Players Novartis, Kite Pharma, GlaxoSmithKline, Spark Therapeutics - Cole of Duty

Viral Vectors And Plasmid DNA Manufacturing Market by Manufacturers, Regions, Type and Application, Forecast to 2026 – Cole of Duty

The Viral Vectors And Plasmid DNA Manufacturing market has witnessed growth from USD XX million to USD XX million from 2014 to 2019. With the CAGR of X.X%, this market is estimated to reach USD XX million in 2026.

The report mainly studies the size, recent trends and development status of the Viral Vectors And Plasmid Dna Manufacturing market, as well as investment opportunities, government policy, market dynamics (drivers, restraints, opportunities), supply chain and competitive landscape. Technological innovation and advancement will further optimize the performance of the product, making it more widely used in downstream applications. Moreover, Porters Five Forces Analysis (potential entrants, suppliers, substitutes, buyers, industry competitors) provides crucial information for knowing the Viral Vectors And Plasmid Dna Manufacturing market.

Download PDF Sample of Viral Vectors And Plasmid Dna Manufacturing Market report @ https://www.arcognizance.com/enquiry-sample/1006415

Major Players in the global Viral Vectors And Plasmid Dna Manufacturing market include:, Sanofi, Lonza, FinVector, Oxford BioMedica, BioVector NTCC, FUJIFILM Diosynth Biotechnologies, MassBiologics, NTC, Waisman Biomanufacturing, Addgene, Invivogen, ATCC, NBRP, OriGene, Brammer Bio, Cobra Biologics, BioReliance, DSMZ, MolMed, Biovian

On the basis of types, the Viral Vectors And Plasmid Dna Manufacturing market is primarily split into:, Viral Vectors, Plasmid DNA

On the basis of applications, the market covers:, Gene Therapy, Vaccination, Immunotherapy, Formulation development, Others

Brief about Viral Vectors And Plasmid Dna Manufacturing Market Report with [emailprotected] https://www.arcognizance.com/report/global-viral-vectors-and-plasmid-dna-manufacturing-market-report-2019-competitive-landscape-trends-and-opportunities

Geographically, the report includes the research on production, consumption, revenue, market share and growth rate, and forecast (2014-2026) of the following regions:, United States, Europe (Germany, UK, France, Italy, Spain, Russia, Poland), China, Japan, India , Southeast Asia (Malaysia, Singapore, Philippines, Indonesia, Thailand, Vietnam), Central and South America (Brazil, Mexico, Colombia), Middle East and Africa (Saudi Arabia, United Arab Emirates, Turkey, Egypt, South Africa, Nigeria), Other Regions

Chapter 1 provides an overview of Viral Vectors And Plasmid Dna Manufacturing market, containing global revenue, global production, sales, and CAGR. The forecast and analysis of Viral Vectors And Plasmid Dna Manufacturing market by type, application, and region are also presented in this chapter.

Chapter 2 is about the market landscape and major players. It provides competitive situation and market concentration status along with the basic information of these players.

Chapter 3 provides a full-scale analysis of major players in Viral Vectors And Plasmid Dna Manufacturing industry. The basic information, as well as the profiles, applications and specifications of products market performance along with Business Overview are offered.

Chapter 4 gives a worldwide view of Viral Vectors And Plasmid Dna Manufacturing market. It includes production, market share revenue, price, and the growth rate by type.

Chapter 5 focuses on the application of Viral Vectors And Plasmid Dna Manufacturing, by analyzing the consumption and its growth rate of each application.

Chapter 6 is about production, consumption, export, and import of Viral Vectors And Plasmid Dna Manufacturing in each region.

Chapter 7 pays attention to the production, revenue, price and gross margin of Viral Vectors And Plasmid Dna Manufacturing in markets of different regions. The analysis on production, revenue, price and gross margin of the global market is covered in this part.

Chapter 8 concentrates on manufacturing analysis, including key raw material analysis, cost structure analysis and process analysis, making up a comprehensive analysis of manufacturing cost.

Chapter 9 introduces the industrial chain of Viral Vectors And Plasmid Dna Manufacturing. Industrial chain analysis, raw material sources and downstream buyers are analyzed in this chapter.

Chapter 10 provides clear insights into market dynamics.

Chapter 11 prospects the whole Viral Vectors And Plasmid Dna Manufacturing market, including the global production and revenue forecast, regional forecast. It also foresees the Viral Vectors And Plasmid Dna Manufacturing market by type and application.

Chapter 12 concludes the research findings and refines all the highlights of the study.

Chapter 13 introduces the research methodology and sources of research data for your understanding.

Years considered for this report:, Historical Years: 2014-2018, Base Year: 2019, Estimated Year: 2019, Forecast Period: 2019-2026,

Some Point of Table of Content:

Chapter One: Viral Vectors And Plasmid Dna Manufacturing Market Overview

Chapter Two: Global Viral Vectors And Plasmid Dna Manufacturing Market Landscape by Player

Chapter Three: Players Profiles

Chapter Four: Global Viral Vectors And Plasmid Dna Manufacturing Production, Revenue (Value), Price Trend by Type

Chapter Five: Global Viral Vectors And Plasmid Dna Manufacturing Market Analysis by Application

Chapter Six: Global Viral Vectors And Plasmid Dna Manufacturing Production, Consumption, Export, Import by Region (2014-2019)

Chapter Seven: Global Viral Vectors And Plasmid Dna Manufacturing Production, Revenue (Value) by Region (2014-2019)

Chapter Eight: Viral Vectors And Plasmid Dna Manufacturing Manufacturing Analysis

Chapter Nine: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter Ten: Market Dynamics

Chapter Eleven: Global Viral Vectors And Plasmid Dna Manufacturing Market Forecast (2019-2026)

Chapter Twelve: Research Findings and Conclusion

Chapter Thirteen: Appendix continued

List of tablesList of Tables and Figures

Figure Viral Vectors And Plasmid Dna Manufacturing Product PictureTable Global Viral Vectors And Plasmid Dna Manufacturing Production and CAGR (%) Comparison by TypeTable Profile of Viral VectorsTable Profile of Plasmid DNATable Viral Vectors And Plasmid Dna Manufacturing Consumption (Sales) Comparison by Application (2014-2026)Table Profile of Gene TherapyTable Profile of VaccinationTable Profile of ImmunotherapyTable Profile of Formulation developmentTable Profile of OthersFigure Global Viral Vectors And Plasmid Dna Manufacturing Market Size (Value) and CAGR (%) (2014-2026)Figure United States Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Europe Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Germany Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure UK Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure France Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Italy Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Spain Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Russia Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Poland Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure China Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Japan Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure India Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Southeast Asia Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Malaysia Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Singapore Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Philippines Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Indonesia Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Thailand Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Vietnam Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Central and South America Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Brazil Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Mexico Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Colombia Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Middle East and Africa Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Saudi Arabia Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure United Arab Emirates Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Turkey Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Egypt Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure South Africa Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Nigeria Viral Vectors And Plasmid Dna Manufacturing Revenue and Growth Rate (2014-2026)Figure Global Viral Vectors And Plasmid Dna Manufacturing Production Status and Outlook (2014-2026)Table Global Viral Vectors And Plasmid Dna Manufacturing Production by Player (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Production Share by Player (2014-2019)Figure Global Viral Vectors And Plasmid Dna Manufacturing Production Share by Player in 2018Table Viral Vectors And Plasmid Dna Manufacturing Revenue by Player (2014-2019)Table Viral Vectors And Plasmid Dna Manufacturing Revenue Market Share by Player (2014-2019)Table Viral Vectors And Plasmid Dna Manufacturing Price by Player (2014-2019)Table Viral Vectors And Plasmid Dna Manufacturing Manufacturing Base Distribution and Sales Area by PlayerTable Viral Vectors And Plasmid Dna Manufacturing Product Type by PlayerTable Mergers & Acquisitions, Expansion PlansTable Sanofi ProfileTable Sanofi Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Lonza ProfileTable Lonza Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table FinVector ProfileTable FinVector Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Oxford BioMedica ProfileTable Oxford BioMedica Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table BioVector NTCC ProfileTable BioVector NTCC Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table FUJIFILM Diosynth Biotechnologies ProfileTable FUJIFILM Diosynth Biotechnologies Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table MassBiologics ProfileTable MassBiologics Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table NTC ProfileTable NTC Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Waisman Biomanufacturing ProfileTable Waisman Biomanufacturing Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Addgene ProfileTable Addgene Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Invivogen ProfileTable Invivogen Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table ATCC ProfileTable ATCC Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table NBRP ProfileTable NBRP Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table OriGene ProfileTable OriGene Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Brammer Bio ProfileTable Brammer Bio Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Cobra Biologics ProfileTable Cobra Biologics Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table BioReliance ProfileTable BioReliance Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table DSMZ ProfileTable DSMZ Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table MolMed ProfileTable MolMed Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Biovian ProfileTable Biovian Viral Vectors And Plasmid Dna Manufacturing Production, Revenue, Price and Gross Margin (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Production by Type (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Production Market Share by Type (2014-2019)Figure Global Viral Vectors And Plasmid Dna Manufacturing Production Market Share by Type in 2018Table Global Viral Vectors And Plasmid Dna Manufacturing Revenue by Type (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Revenue Market Share by Type (2014-2019)Figure Global Viral Vectors And Plasmid Dna Manufacturing Revenue Market Share by Type in 2018Table Viral Vectors And Plasmid Dna Manufacturing Price by Type (2014-2019)Figure Global Viral Vectors And Plasmid Dna Manufacturing Production Growth Rate of Viral Vectors (2014-2019)Figure Global Viral Vectors And Plasmid Dna Manufacturing Production Growth Rate of Plasmid DNA (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption by Application (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption Market Share by Application (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption of Gene Therapy (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption of Vaccination (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption of Immunotherapy (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption of Formulation development (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption of Others (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption by Region (2014-2019)Table Global Viral Vectors And Plasmid Dna Manufacturing Consumption Market Share by Region (2014-2019)Table United States Viral Vectors And Plasmid Dna Manufacturing Production, Consumption, Export, Import (2014-2019)Table Europe Viral Vectors And Plasmid Dna Manufacturing Production, Consumption, Export, Import (2014-2019)Table China Viral Vectors And Plasmid Dna Manufacturing Production, Consumption, Export, Import (2014-2019)Table Japan Viral Vectors And Plasmid Dna Manufacturing Production, Consumption, Export, Import (2014-2019)Table India Viral Vectors And Plasmid Dna Manufacturing Production, Consumption, Export, Import (2014-2019)Table Southeast Asia Viral Vectors And Plasmid Dna Manufacturing Production, Consumption, Export, Import (2014-2019)Table Central and South America Viral Vectors And Plasmid Dna Manufacturing Production, Consumption, Export, Import (2014-2019)continued

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As this pandemic is ongoing and leading to dynamic shifts in stocks and businesses worldwide, we take into account the current condition and forecast the market data taking into consideration the micro and macroeconomic factors that will be affected by the pandemic.

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Viral Vectors And Plasmid DNA Manufacturing Market by Manufacturers, Regions, Type and Application, Forecast to 2026 - Cole of Duty

Juvenile Macular Degeneration (Stargardt Disease) Treatment Market Research, Recent Trends and Growth Forecast 2025 – Express Journal

The Juvenile Macular Degeneration (Stargardt Disease) Treatment Market report upholds the future market predictions related to Juvenile Macular Degeneration (Stargardt Disease) Treatment market size, revenue, production, Consumption, gross margin and other substantial factors. It also examines the role of the prominent Juvenile Macular Degeneration (Stargardt Disease) Treatment market players involved in the industry including their corporate overview. While emphasizing the key driving factors for Juvenile Macular Degeneration (Stargardt Disease) Treatment market, the report also offers a full study of the future trends and developments of the market.

The analysis on Juvenile Macular Degeneration (Stargardt Disease) Treatment Market presents a realistic assessment of the current market situation, including the Juvenile Macular Degeneration (Stargardt Disease) Treatment market size with regards to the volume and renumeration. The Juvenile Macular Degeneration (Stargardt Disease) Treatment market report has been prepared based on the synthesis, analysis, and clarification of information about the global Juvenile Macular Degeneration (Stargardt Disease) Treatment market from dedicated sources. The report is a collection of significant data related to the competitive landscape of the industry.

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Juvenile Macular Degeneration (Stargardt Disease) Treatment market size report mentions the key geographies, market landscapes alongside the product price, revenue, volume, production, supply, demand, market growth rate, and forecast etc. The study offers a thorough assessment of the products manufactured by the firms, specifications, including their application frame of reference.

The Juvenile Macular Degeneration (Stargardt Disease) Treatment market report consist competitive study of the major Juvenile Macular Degeneration (Stargardt Disease) Treatment manufacturerswhich will help to develop a marketing strategy.

Top key playersof industry are covered in Juvenile Macular Degeneration (Stargardt Disease) Treatment Market Research Report:

Synopsis of the competitive landscape

Split by product type,with production, revenue, price, market share and growth rate of each type, can be divided into:

Stem Cell Therapy, Gene Therapy and Others

Split by application,this report focuses on consumption, market share and growth rate of Juvenile Macular Degeneration (Stargardt Disease) Treatment market in each application and can be divided into:

Hospitals, Eye Clinics and Others

An overview of market segmentation

Major Key factors of Juvenile Macular Degeneration (Stargardt Disease) Treatment market is explained in this report are as below:

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Juvenile Macular Degeneration (Stargardt Disease) Treatment Market Research, Recent Trends and Growth Forecast 2025 - Express Journal

Study Demonstrating Role of IdeS in Enabling of Gene Therapy in the Presence of Neutralizing Anti-AAV Antibodies Published in Nature Medicine |…

DetailsCategory: Proteins and PeptidesPublished on Monday, 01 June 2020 18:40Hits: 389

PHILADELPHIA, PA, USA I June 01, 2020 I Spark Therapeutics, a fully integrated, commercial gene therapy company dedicated to challenging the inevitability of genetic disease, today announced the publication of new research in the journal Nature Medicine demonstrating that treatment with immunoglobulin G-degrading (IgG) enzyme of Streptococcus pyogenes (IdeS) resulted in rapid and transient reduction of neutralizing anti-adeno-associated virus (AAV) antibodies and restored gene therapy efficacy in controlled laboratory tests of animal models.

One of the main challenges associated with AAV-mediated gene therapy is neutralizing antibodies that can impact the ability to administer gene therapy, saidFederico Mingozzi, Ph.D., chief scientific officer atSpark Therapeutics. The IdeS technology has the potential to eliminate anti-AAV antibodies that allow for the extended use of gene therapy in a larger segment of candidates who may have been excluded due to pre-existing or developing neutralizing antibodies and also enable vector re-administration.

The study was conducted by an international collaboration of researchers from Spark Therapeutics in the U.S., and Genethon, the Centre de Recherche des Cordeliers (Inserm, Sorbonne Universit, Universit de Paris) and the National Centre for Scientific Research (CNRS) in France.

AAV-mediated gene therapy allows for the treatment of a growing number of diseases in patients today, however the presence of neutralizing anti-AAV antibodies can lead to limitations of this technology. Specifically, neutralizing anti-AAV IgG pre-exist in up to seventy percent of the population and block the entry of viral vector particles in a given target tissue. Furthermore, high-titer anti-AAV antibody levels usually develop following vector administration and persist long-term thereafter, preventing vector re-administration. To date, researchers have been limited in their ability to bypass the neutralizing activity of anti-AAV IgG.

Study FindingsThe study demonstrated that treatment with the IgG-degrading enzyme IdeS, an endopeptidase from Streptococcus pyogenes that specifically hydrolyses human IgG, resulted in a rapid and transient elimination of neutralizing anti-AAV IgG and restored gene therapy efficacy. IdeS is an endopeptidase able to degrade circulating IgG that is currently being tested in transplant patients.

Researchers demonstrated efficacy in vivo using animal models of liver gene transfer, including hemophilia A and B. Hemophilia is a rare genetic bleeding disorder that causes a delay in clot formation as a result of a deficiency in coagulation factor VIII or IX for hemophilia A or B, respectively. In both mice and non-human primates with neutralizing anti-AAV IgG, IdeS treatment prior to the injection of AAV vectors eliminated neutralizing IgG and rescued the expression of the factor VIII or IX in hepatocytes.

Furthermore, administration of AAV vectors systematically induces a neutralizing anti-AAV immune response, making gene therapy inefficient upon subsequent injections of AAV vectors. The study also demonstrated that treatment with IdeS restores the efficacy of the re-administration of AAV vectors, allowing for efficient transgene expression in non-human primates. The research shows that IdeS allows the repeated administration of AAV vectors by blocking the neutralizing activity of anti-AAV IgG in small and large animal models.

Additional studies in the field of gene therapy have the potential to translate these findings to human trials, with the goal of opening a therapeutic window for patients with neutralizing anti-AAV antibodies. Spark will assess and investigate the potential impact of the IdeS technology on its current gene therapy programs and potential applications in the future.

About Spark Therapeutics AtSpark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challengethe inevitability of genetic diseases,includingblindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.We currently have four programs in clinical trials.At Spark, a member of the Roche Group, we see the path to a world where no life is limited by genetic disease. For more information, visit http://www.sparktx.com, and follow us on Twitter and LinkedIn.

SOURCE: Spark Therapeutics

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Tech Fort Worth client receives $2M research award from NEI – Fort Worth Business Press

Researchers at Bedford-based Nanoscope Technologies LLC have received a multi-year, $2-million plus Small Business Innovation ResearchAward from the National Eye Institute (NEI), a division of the National Institutes of Health (NIH), for its gene therapy treatment.

Nanoscopes research is advancing the development of a therapeutic gene and delivery platform for treating degenerative eye diseases, including dry age-related, macular degeneration (dry-AMD). The projected deliverable is a non-viral, spatially-targeted gene delivery platform for AMD therapy. It would restore visual response with targeted delivery of ambient-light, activatable opsin into the retina.

Our opto-genetic platform and laser delivery technologies are synergistic and will allow treatment for fully- and partially-degenerated retina, said Samarendra Mohanty, Ph.D., Principal Investigator of the grant and Chief Scientific Officer at Nanoscope.

This technology provides a unique therapeutic option for treating dry-AMD patients for which there is no approved therapy, said Vittorio Porciatti, Head of Research at the Bascom Palmer Eye Institute in south Florida.

The Nanoscope team developed Multi-Characteristic Opsins (MCOs) to sensitize cells toward low level of white light so that vision is improved at ambient room light. Not requiring any external stimulation device and sensitivity to broad range of colors makes our approach unique as there is less chance of phototoxicity and damage to the retina, said Nanoscope CEO Sulagna Bhattacharya.

Gene delivery by commonly used viral transfection may lead to unexpected inflammatory and immunological responses.To minimize collateral damage while inserting therapeutic genes, Nanoscopes process uses a low-power, near-infrared (NIR) laser beam whose intensity is locally enhanced by use of gold nanoparticles bound to the targeted cell membranes. This platform technology is being explored for delivery of genes for vaccination against diseases such as COVID-19.

Nanoscope is focused on advancing cell-gene therapy through various patented key platform technologies. Founded in 2009 by Mohanty, it has received multiple SBIR awards, National Institutes of Health R01 grants, and patents that focus on optical stimulation, gene delivery and imaging for neural activity monitoring.

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Regeneron and Intellia Expand Their Hunt for Hemophilia A and B Treatments – BioSpace

Regeneron Pharmaceuticals and Intellia Therapeutics announced on Monday that they will be expanding an existing collaboration. Regeneron will have the rights to develop products for additional in viro CRISPR/Cas9-based therapeutic targets. In addition, both companies will work on creating products for the treatment of hemophilia A and B.

Regeneron will receive the non-exclusive rights to independently develop and commercialize ex vivo gene edited products, and Intellia will receive an upfront payment of $70 million. Regeneron will make an additional equity investment in Intellia of $30 million.

"The Regeneron team works hard to push the boundaries of science and technology, and we believe the precise in vivo gene insertion capabilities jointly developed with Intellia could be a promising therapeutic platform with significant potential in many diseases, including those that have been historically difficult to treat, said George D. Yancopoulos, M.D., Ph.D., Co-Founder, President and Chief Scientific Officer, Regeneron. We're pleased to expand our work with Intellia, a like-minded group of scientists focused on maximizing the potential of CRISPR/Cas9 in order to help as many patients as possible."

Both companies have made significant advances with Intellias CRISPR/Cas9 platform to perform the targeted insertion of therapeutic proteins and antibodies. In preclinical studies, Intellia and Regeneron demonstrated the first CRISPR/Cas9-mediated targeted transgene insertion in the liver of non-human primates. This generated normal or higher levels of circulating Factor IX, a blood-clotting protein that is missing or defective in hemophilia B patients.

"We're excited to work with Regeneron on what could potentially be a cure for hemophilia A and B in this expansion of our successful collaboration that builds on our leading insertion capabilities," said Intellia's Chief Executive Officer and President, John M. Leonard, M.D. "We believe that our CRISPR/Cas9-based technology addresses the limitations of current replacement and gene therapy approaches, and importantly, may provide a durable, potentially life-long solution to these genetic diseases."

Regeneron and Intellia arent the only companies looking for treatments for hemophilia. BioMarin Pharmaceutical, Inc. provided updates to the previously reported results from its open-label Phase 1/2 study on May 31. The trial looked into valoctocogene roxaparvovec as a form of treatment for adults with severe hemophilia A. People with this condition lack the necessary functioning Factor VIII proteins to help their blood clot.

All subjects in both the 6e13 vg/kg and 4e13 vg/kg cohorts remain off prophylactic Factor VIII treatment since being given a single dose of valoctocogene roxaparvovec. Cumulative mean annualized bleed rates remain less than one in both cohorts and below pre-treatment baseline levels.

Overall, the safety profile of valoctocogene roxaparvovec remains consistent with previously reported data, and no participants experienced thrombotic events. The U.S. Food and Drug Administration is currently reviewing the biologics license application from BioMarin.

"It's been a privilege to participate in this pioneering research and to observe how the patients on the study have done so much to improve our understanding of gene therapy research for hemophilia A. This additional data is an important step toward a potential first treatment of its kind for this devastating disease," said Professor John Pasi, M.B., Ch.B., Ph.D., from Barts and the London School of Medicine and Dentistry; chief investigator for the valoctocogene roxaparvovec Phase 1/2 study, and a principal investigator for the Phase 3 study. "Each year of data increases our knowledge of safety and efficacy and contributes to the growing body of scientific data on gene therapies in general and hemophilia A in particular."

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Regeneron and Intellia Expand Their Hunt for Hemophilia A and B Treatments - BioSpace

Toronto centre solving cell manufacturing challenges to benefit patients and global industry CCRM and Cytiva, formerly part of GE Healthcare Life…

TORONTO and MARLBOROUGH, Mass., June 02, 2020 (GLOBE NEWSWIRE) -- With Health Canada and the Food and Drug Administration beginning to approve and reimburse cell and gene therapies in significant numbers, the demand for cell and viral vector manufacturing will continue to grow. Consequently, the industrialization challenges associated with the variability of cell and gene therapies, and with manufacturing them on a commercial scale, must be overcome. CCRM and Cytiva, formerly part of GE Healthcare Life Sciences, have renewed their Collaboration Agreement for continued operation of the Centre for Advanced Therapeutic Cell Technologies (CATCT), which was created to accelerate the development and adoption of cell manufacturing technologies for novel regenerative medicine-based therapies.

Together, CCRM and Cytiva have established a commercialization hub where great minds, state-of-the-art equipment and a spirit of innovation meet, says Michael May, President and CEO of CCRM. Continuing to partner in the operation of CATCT will enable us to move the cell and gene therapy industry closer to fulfilling its promise of creating cures, and enabling treatments to get to patients.

By creating an innovative platform and approach to tackle the issues facing commercialization of living therapies, we are supporting the viability of the regenerative medicine industry, says Catarina Flyborg, Vice President, Cell & Gene Therapy, Cytiva. In CATCT, we are creating the technologies, processes and equipment that will enable our customers, and the broader industry, to achieve its goals and help patients.

Established in 2016, CATCT is a partnership between CCRM and Cytiva, with initial funding from the Federal Economic Development Agency for Southern Ontario (FedDev Ontario). Its staff of 40 works in a 10,000 ft (~930 m) process development facility, located in the MaRS Discovery District, next to Torontos world-leading hospitals and the University of Toronto.

The global regenerative medicine market was valued at US$23.8 billion (2018), and it is anticipated to grow to US$151 billion by 2026 with an annual growth rate of 26.1 per cent.i Operating CATCT allows CCRM and Cytiva to address the manufacturing bottlenecks that would otherwise have the potential to impede the industrys growth.

CATCTs key areas of expertise are:

The work conducted in CATCT can be categorized as follows: the first is fee-for-service development projects that advance customers therapeutic technologies towards industrialization; second, the teams New Product Introductions (NPIs) efforts provide core biological expertise in Cytivas product development process; finally, internal technology development builds additional capabilities and innovative solutions for cell and gene therapies.

A recent success stemming from the work being done in CATCT is the involvement of CCRM and Cytiva in a consortium led by iVexSol Canada, with conditional funding from Next Generation Manufacturing Canada (NGen), to build an advanced manufacturing platform for lentiviral vectors. As core partners in this consortium, which was announced in August 2019, CCRM will provide supporting manufacturing infrastructure and downstream processing capabilities, and Cytiva will share expertise of manufacturing processes, and access to and use of specialized tools and technology.

The new collaboration agreement between CCRM and Cytiva has a three-year term and it became effective on October 15, 2019. The funding will be a combination of in-kind contributions, milestone payments, reinvested fee-for-service revenue and any successful grant opportunities. FedDevs funding of CATCT was for a three-year term and ended in December 2018.

About CCRM CCRM, a Canadian not-for-profit organization funded by the Government of Canada, the Province of Ontario, and leading academic and industry partners, supports the development of regenerative medicines and associated enabling technologies, with a specific focus on cell and gene therapy. A network of researchers, leading companies, strategic investors and entrepreneurs, CCRM accelerates the translation of scientific discovery into new companies and marketable products for patients, with specialized teams, funding, and infrastructure. CCRM is the commercialization partner of the Ontario Institute for Regenerative Medicine and the University of Torontos Medicine by Design. CCRM is hosted by the University of Toronto. Visit us at ccrm.ca.

About CytivaCytiva is a 3.3 billion USD global life sciences leader with nearly 7,000 associates operating in 40 countries dedicated to advancing and accelerating therapeutics. As a trusted partner to customers that range in scale and scope, Cytiva brings speed, efficiency and capacity to research and manufacturing workflows, enabling the development, manufacture and delivery of transformative medicines to patients. Visit http://www.cytiva.com for more.

For more information, please contact:

Stacey JohnsonDirector, Communications and Marketing, CCRM416-946-8869stacey.johnson@ccrm.ca

Colleen ConnollySenior Communications Manager, Cytiva774-245-3893Colleen.Connolly@cytiva.com

ihttps://www.fortunebusinessinsights.com/industry-reports/regenerative-medicine-market-100970

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Toronto centre solving cell manufacturing challenges to benefit patients and global industry CCRM and Cytiva, formerly part of GE Healthcare Life...

growth factors to cut cell therapy COGS – Bioprocess Insider – BioProcess Insider

Cell therapy manufacturing costs could be reduced dramatically using immobilized growth factors in culture according to research.

Industry interest in cell therapies has increased significantly in recent years. According to a report by US industry group PhRMA, there are 362 cell and gene therapies in clinical development, up from 289 in 2018.

The surge in cell therapies entering the clinic is the result of years of pioneering research by Americas biopharmaceutical research companies, according to PhRMA.

Image: iStock/Sviatlana Zyhmantovich

It also reflects the potential revenue cell therapies can generate. According to analysis by market research firm Bioinformant while prices vary, all cell therapies are expensive.

For example, cell therapies for wound care cost between $1,500 and $2,500 per administration, while those delivered via injection can cost up to $200,000 per shot. Cell-based gene therapies are valued in the $500,000 to $1 million range.

But revenue is not the only factor. The prices also reflect the high cost of goods sold (COGS) for a cell therapy according to Bioinformant.

The cost of manufacturing a cell product cannot be compared with small molecule products manufactured by pharmaceutical companies or biomolecules produced by biotechnology companies. Cell therapies are costlier to develop, with autologous cell products commanding the highest price tags.

In general, the manufacturing cost of autologous cell product is many times higher than that of an allogeneic product and this is reflected in the market pricing the authors wrote.

Growth factors as the name suggests are proteins that stimulate cell growth. They are one of the most costly components of the cell therapy manufacturing process according to a 2018 study published in Frontiers in Medicine.

The authors who looked at production strategies for allogenic therapies said Identifying mimetic-based alternatives to costly growth factors or leaner media alternatives would help to substantially reduce cost of goods.

Another approach is to immobilize growth factors used in cell culture according to the team behind a study due to be published in Frontiers in Bioengineering and Biotechnology.

Author Marion Brunck, associate professor at the Monterrey Institute of Technology and Higher Education (ITESM), told Bioprocess Insider Immobilizing growth factors is a good idea in general, as the process stabilizes the protein and prevents its degradation, internalization, i.e. bioactivity does not decrease at the same rate as with soluble proteins.

However, some growth factors must be internalized for the transduction cascade to occur appropriately, in these situations, a different approach may be sought out, for example immobilizing the growth factor by physical entrapment which allow a gradual release in culture media.

The take home message is that it may be a very good idea to decrease production cost but the biology of the growth factor (GF) and its signaling mechanistics must be well known.

Brunck added that, The impact of GF immobilization on cost will definitely vary depending on each individual process. In some cases, culture media accounts for more than half of the cost of goods, and within the cost of culture media, GF is again a big contributor.

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Rise and Opportunities in Gene Therapy Market, Poised to Register Downturn due to COVID-19 Pandemic – The Cloud Tribune

A business intelligence report on the global Gene Therapy market offers quantitative estimation of the opportunities and qualitative assessment various growth dynamics. The study highlights estimations of the opportunities in the historical period, and offers several projections during the forecast period.

The following are taken into consideration:

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Key Focus Areas of Report on Global Gene Therapy Market

The study on the Gene Therapy market includes detailed market estimations of opportunities in various segments and their share/size globally in each year during the forecast period. The following are the broad insights that form the backbone of the evaluation of the Gene Therapy market.

Segmental Analysis Comprise the following.

Based on End-use Industry/Application,

Based on Product/Technology,

Based on Region,

Top players include

What Businesses Can Hope to Get in Business Intelligence on Gene Therapy Market?

The study insights on the Gene Therapy market growth dynamics and opportunities highlights various key aspects, in which crucial ones are:

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Insights and Perspectives that make this Study on Gene Therapy Market Stand Out

The analysts who have prepared the report have been keen observers of the dynamism due to macroeconomic upheavals. Using the best industry assessment quantitative methods and data integration technologies, they have come out with a holistic overview of the future growth trajectories of the Gene Therapy market. Fact-based insights and easy-to-comprehend information based on wide spectrum of market data is what makes this study different from competitors.

The following evaluations create a differentiating approach towards understanding the market dynamics and presenting the crux to its readers:

About Fact.MR

Fact.MR is a fast-growing market research firm that offers the most comprehensive suite of syndicated and customized market research reports. We believe transformative intelligence can educate and inspire businesses to make smarter decisions. We know the limitations of the one-size-fits-all approach; thats why we publish multi-industry global, regional, and country-specific research reports.

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Rise and Opportunities in Gene Therapy Market, Poised to Register Downturn due to COVID-19 Pandemic - The Cloud Tribune

Cell And Gene Therapy Consumables Market to Witness Huge Growth by 2027 | Amgen Inc., ATLANTA BIOLOGICALS, bluebird bio, Inc., Cook Medical, Dendreon…

Global Cell And Gene Therapy Consumables market report comprises of detailed explanation of the market definition, classifications, applications, commitments and market trends. The above-mentioned report provides the levels and revenue of the CAGR for the historical year 2016, the base year 2017 and the forecast period for the Cell And Gene Therapy Consumables market between 2020 and 2027. Getting data regarding competitive landscape is a great gain of this market document. Consequently, the actions or actions of most important market game enthusiasts and brands are analyzed within the Cell And Gene Therapy Consumables Research Report. It provides data on all recent developments, launches of products, joint ventures, mergers and acquisitions by the various key market dominant players and brands. These key players company profiles are provided in this report. In the 2020-2027 forecast period, the market will touch new heights. This Cell And Gene Therapy Consumables report lays down all the restrictions and drivers for the market derived from SWOT analysis.

Negative consequences of internet of things could act as a market restraint for Cell And Gene Therapy Consumables in the above mentioned foretasted period.

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Key market [emailprotected]

The report provides both qualitative and quantitative research of cell and gene therapy consumables market as well as provides comprehensive insights and development methods adopted by the prominent market players. Some of the key market participants in the cell and gene therapy consumables market are Amgen Inc., ATLANTA BIOLOGICALS, bluebird bio, Inc., Cook Medical, Dendreon Pharmaceuticals LLC, Fibrocell Science, Inc., General Electric, Kolon TissueGene, Inc., Orchard Therapeutics plc, Pfizer, Inc., PromoCell GmbH, RENOVA THERAPEUTICS, Sibiono GeneTech Co. Ltd., Spark Therapeutics, Inc., Vericel, ViroMed Co., Ltd., and Vitrolife. These players have adopted growth strategies such as new product launches, partnerships, collaborations, mergers and acquisitions, and joint ventures (JVs) in order to gain a competitive advantage. For instance, in May 2019, General Electric launched chronicle automation software for cell therapy. In October 2018, bluebird bio, Inc. received an approval from European Medicines Agency (EMA) for its investigational LentiGlobin gene therapy for the treatment of adolescents and adults with transfusion-dependent -thalassemia (TDT).

Key Market Competitors: Global Cell And Gene Therapy Consumables Market

Cell And Gene Therapy Consumables Market Country Level Analysis

Cell And Gene Therapy Consumables market is analysed and market size, volume information is provided by country, product type, cable category, application and end use as referenced above.

The countries covered in the Cell And Gene Therapy Consumables market report are the U.S., Canada and Mexico in North America, Brazil, Argentina and Rest of South America as part of South America, Germany, Italy, U.K., France, Spain, Netherlands, Belgium, Switzerland, Turkey, Russia, Rest of Europe in Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA).

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Rapid Business Growth Factors

In addition, the market is growing at a fast pace and the report shows us that there are a couple of key factors behind that. The most important factor thats helping the market grow faster than usual is the tough competition.

Competitive Landscape and Cell And Gene Therapy Consumables Market Share Analysis

Cell And Gene Therapy Consumables market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, regional presence, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies focus related to Cell And Gene Therapy Consumables market.

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Table Of Contents: Global Cell And Gene Therapy Consumables Market

Part 01: Executive Summary

Part 02: Scope Of The Report

Part 03: Research Methodology

Part 04: Market Landscape

Part 05: Pipeline Analysis

Part 06: Market Sizing

Part 07: Five Forces Analysis

Part 08: Market Segmentation

Part 09: Customer Landscape

Part 10: Regional Landscape

Part 11: Decision Framework

Part 12: Drivers And Challenges

Part 13: Market Trends

Part 14: Vendor Landscape

Part 15: Vendor Analysis

Part 16: Appendix

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Cell And Gene Therapy Consumables Market to Witness Huge Growth by 2027 | Amgen Inc., ATLANTA BIOLOGICALS, bluebird bio, Inc., Cook Medical, Dendreon...

Shinshu University and Toshiba Develop Tumor-Tropic Liposome Technology that Carries Therapeutic Genes into Cancer Cells – BioSpace

TOKYOToshiba Corporation (TOKYO: 6502, hereinafter Toshiba) and a team led by Professor Yozo Nakazawa at the Department of Pediatrics, Shinshu University, (hereinafter "Shinshu University"), have together developed a tumor-tropic liposome technology for gene therapy*1. The technology uses unique, nano-sized biodegradable liposomes developed by Toshiba to accurately and efficiently deliver therapeutic genes to targeted cancer cells, and achieves safer gene delivery than viruses used as carriers.

The tumor-tropic liposome developed by Toshiba can deliver therapeutic genes selectively to tumor cells, not normal cells. Shinshu university and Toshiba have demonstrated that the tumor-tropic liposome can deliver the therapeutic gene to T-cell leukemia cells and achieve a 30-fold increase in uptake and 400-fold increase in gene expressionthan normal T-cells. The technology is expected to reduce burdens on patients during treatment, and offers the potential to develop new treatments for other cancers.

Shinshu University and Toshiba presented the technology at the 2020 Annual Meeting of the American Society for Gene & Cell Therapy (ASGCT 2020) on May 12 (presenter: Shoji Saito, Shinshu University School of Medicine).

Gene therapy applies the latest advances in biotechnology to treatment of disease at the level of gene expressionusing information from a gene to synthesize a functional gene product in an affected cell. In cancer therapy, it inserts therapeutic genes into target cells, where they can repair and enhance cell functions. While a highly promising way forward, even for cancers that are difficult to treat, gene therapy is not yet settled science, and there are still hurdles to overcome, including how best to get genes into cells.

Therapeutic genes need a carrier to introduce them into a cell, because the nucleic acid that encodes the DNA and RNA that triggers gene expression cannot penetrate the cell membrane. Current approaches often achieve this by using a virus as the carrier. However, it brings with concerns for the risk of infection and cell tropism.

Shinshu University and Toshiba are collaborating in research to utilize biodegradable liposomes as non-virus carriers of therapeutic genes. They have developed tumor-tropic liposomes that safely and effectively deliver therapeutic genes to targeted cancer cells.

Toshiba has applied its know-how in materials technology to the design of liposomes with lipids that degrade naturally in cells, as their major component. The companys research has confirmed that adjusting lipid composition to cell membrane characteristics realizes liposomes that can carry therapeutic genes to specific target cells (Figure 1). The delivery is also highly efficient, as a comparison of tumorous cells and normal T cells found that the former surpassed the latter in therapeutic gene uptake and expression by 30-times and 400 times respectively.

Figure 1 The biodegradable liposome technology targeted by the research

Shinshu University has demonstrated that the biodegradable liposome is an effective and efficient carrier for delivering therapeutic genes into tumor cells by experimentally administering tumor-tropic liposomes carrying therapeutic genes into T-cell tumor bearing mice. The results also confirmed successful suppression of tumor growth (Figure 2). As there is no effective treatment for relapsed or refractory T-cell tumors, Shinshu University is continuing research toward a solution.

Figure 2 Verification of the effects of tumor-tropic liposomes on mice bearing T-cell tumors

Toshiba will continue to contribute its specialized capabilities in materials science to the collaboration with Shinshu University, in support of further enhancing the delivery and application of cancer-directed liposomes and promoting the widespread use of gene therapy.

*1 Gene Therapy

A method of treating a disease by inserting a gene into a cell in order to restore, enhance or suppress its function. It is based on the physiological action of a protein produced by the gene.

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Shinshu University and Toshiba Develop Tumor-Tropic Liposome Technology that Carries Therapeutic Genes into Cancer Cells - BioSpace

Gene Therapy Market 2020 | Worldwide Analysis By Financial Overview, Research Methodologies and Forecast To 2028 – Azizsalon News

In its forthcoming study ofGlobalGene therapy Market,Quince Market Insights offers crucial insights into the global market forGene therapy. In terms of revenue, the global market forGene therapyis expected to record a CAGR ofXXpercent over the forecast period, due to various factors with regard to which QMI provides detailed insights and forecasts.

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The demand forGene therapyis projected to report a growth rate ofXXper cent year-over-year by2028. The demand forGene therapyis segmented by product type, end-users, and regions.

During consideration of segments and sub-segments some industry standards and parameters are considered. Historical information on theGene therapymarket as well as future occurrences which could impact market growth includes a microscopic market view. In view of the value for the base year, the market volume or demand is determined. Main regions are kept in mind with special emphasis on the highest demand and growth countries. The report details country-specific economic indicators and drivers with the investment opportunities offered to the investors concerned. Key insights are written into a table and easily readable structured.

The growth of the market forGene therapyis related to the dental industry that would benefit a great deal from the ongoing change in production using digital methods. As the technology continues to advance traditional methods, further improvements in treatments and outcomes resulting from digital manipulation are improved.Products are more furiously embraced in emerging markets because they are cost-effective and offer good quality that fits the present condition and certain points ofGene therapyrefund policies.

Gene therapymarket research report provides an in-depth analysis of the market overall, primarily on issues bordering on the market size, growth scenario, opportunity potentials, business environment, trend analysis and competitive market analysis ofGene therapy. The information includes the profile of the company, annual turnover, the types of products and services it provides, income generation, which gives businesses direction to take important steps.Gene therapyresearch reportprovides pin-point analysis of varying dynamics of competition and is ahead of competitors in theGene therapylike:Alliance for Regenerative Medicine, Gilead Sciences, Inc., Novartis AG, Sibiono GeneTech Co. Ltd.

This report analyses the trends that drive the growth of each segment on a global as well as regional level, and provides potential takeaways that could prove significantly useful for manufacturers preparing to enter the market.

In this article, we addressed the specific approaches these businesses have adopted with regard to developing their products, creating new manufacturing facilities, consolidating the market and advanced R&D initiatives. The study ends with key takeaways for players already present on the market and new players preparing to enter the marketGene therapy.

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Market Segmentation:

By Product: Yescarta Kymriah Luxturna Strimvelis GendicineBy Application: Ophthalmology Oncology Adenosine Deaminase Deficient Severe Combined ImmunodeficiencyBy Region: North America North America, by CountryUSCanadaMexico North America, by Product North America, by Application Western Europe Western Europe, by CountryGermanyUKFranceItalySpainThe NetherlandsRest of Western Europe Western Europe, by Product Western Europe, by Application Asia Pacific Asia Pacific, by CountryChinaIndiaJapanSouth KoreaAustraliaIndonesiaRest of Asia Pacific Asia Pacific, by Product Asia Pacific, by Application Eastern Europe Eastern Europe, by CountryRussiaTurkeyRest of Eastern Europe Eastern Europe, by Product Eastern Europe, by Application Middle East Middle East, by CountryUAESaudi ArabiaQatarIranRest of Middle East Middle East, by Product Middle East, by Application Rest of the World Rest of the World, by CountrySouth AmericaAfrica Rest of the World, by Product Rest of the World, by Application

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Gene Therapy Market 2020 | Worldwide Analysis By Financial Overview, Research Methodologies and Forecast To 2028 - Azizsalon News

Cell and gene therapies – Lexology

In recent years, we have seen a trend towards the launch of new gene and cell therapies with record-breaking price tags. Such headline-grabbing launches are becoming more and more frequent, as the pipeline for advanced therapies at all stages of development continues to grow at a rapid pace[1]. We are also seeing industry and payers adopting new innovative pricing models for those products, such as outcome-based reimbursement and annuity payment models. In this article, we discuss these emerging alternative pricing models and consider the impact they may have on related licensing arrangements.

Current trends

In May 2019 AveXis, a subsidiary of pharmaceutical giant Novartis, announced that it had received approval from the US Food and Drug Administration to market its gene therapy Zolgensma for the treatment of paediatric patients with spinal muscular atrophy (SMA). Although this is the first promise of a cure for this debilitating and lethal condition, the media coverage focussed instead on Zolgensmas price tag, which at $2.1 million per patient makes it (currently) the worlds most expensive single-dose medicine.

Zolgensma is illustrative of a general trend in gene and cell therapies that have reached the market in recent years and established a new standard of pricing for single-treatment medicines. While manufacturers point to the relative cost-effectiveness of such treatments (which may offer a one-off cure for severe conditions that otherwise would require several years worth of conventional treatments and care) public and private payers are concerned about this new escalating pricing paradigm.

Health care systems may be able to absorb such high prices for rare diseases with small patient populations. However, the current reimbursement systems will be under severe pressure if (as is hoped) pipelines for advanced cell and gene therapies result in treatments for common conditions such as diabetes or heart disease. The Institute for Clinical and Economic Review in the US has estimated that if gene therapies are developed to treat only one in ten American patients with a genetic condition approximately 1% of the total population the cumulative budget impact could rise to $3 trillion[2]. For comparison, the projected total healthcare spend in the US for 2019 is $3.8 trillion[3].

Alternative Pricing Models

The pharmaceutical industry has sought to counter criticism over the high price tags for gene and cell therapies by coupling these revolutionary therapies with new and unconventional pricing and reimbursement mechanisms.

One alternative structure that has been adopted is an annuity based model which spreads the payment for an expensive treatment over several years in a pre-agreed payment plan, thus minimising the up-front cost to payers.

Another approach adopted by the industry, and perhaps an even clearer way to demonstrate value to payers, has been to tie reimbursement to patient outcomes. The industry has negotiated several of these outcomes-based reimbursement models with public and private payers for cell and gene therapies. Reimbursement payments to the drug maker under this model are conditional upon the patient reaching specific clinical outcomes by set deadlines. Depending on the model, a patients failure to meet the specified clinical outcome can result in the drug maker having to refund payments received and/or forfeit any subsequent payments.

These new models are also being blended to create payment plans which combine annuity-style payments with rebates and outcomes-dependent instalments. We expect that in the years to come other creative payment models will emerge and be adapted from other therapy areas. For example, in Australia, the government has used a subscription style model that allowed it to pay a lump sum to drug makers for unlimited access for patients to curative hepatitis C treatments such as Sovaldi for a period of time.

Example annuity and outcomes-based reimbursement models for cell and gene therapies:

Licensing challenges

Cell and gene therapies often have their roots in academic research laboratories and the main players in this field of treatments have close ties and valuable licensing agreements with academic research institutions. For example, AveXis, the biotech company that developed Zolgensma, started as a spin-out to continue research conducted at the Center for Gene Therapy at Nationwide Childrens Hospital in Columbus, Ohio. To further its spinal muscular atrophy work, the biotech also licensed a patent owned by Martine Barkats, a researcher at the Institut de Myologie, Paris. Shortly after, AveXis was bought by Novartis for $8.7 billion. Cell and gene therapies such as Zolgensma will generally have more constituent parts (such as promoters, viral vectors and cell lines) than other more conventional small molecule therapies. This means that a party commercialising a cell or gene therapy will often need to license in more third party intellectual property or materials than a manufacturer of a conventional small molecule therapy. Most cell and gene therapies reaching the market are therefore likely to be underpinned by one or more licence agreements.Licensing challenges

While much has been said about the impact of alternative pricing and reimbursement mechanisms on drug makers, payers and patients, we want to also consider the impact on licensors of the intellectual property which enables the development and manufacture of a therapy. In particular, how future pricing and reimbursement models can impact the royalties payable by licensees to their licensors. One inherent challenge is that these licences are generally negotiated many years before the commencement of discussions with payers on pricing and reimbursement mechanisms, making it very difficult to predict which scenarios will be relevant down the line. The positions of all of the stakeholders in the pricing debate are also constantly evolving, especially as data on the cost-effectiveness of annuity and outcomes-based models continues to accumulate. One factor which makes things particularly difficult for licensors in forecasting potential future royalty streams for these products is that a licensor would rarely have any involvement in negotiations regarding pricing and reimbursement so will have no control over the model adopted.

Annuity model challenges

Generally a licensor will only receive royalties once the licensee has itself received (or at least invoiced) payment from payers. An annuity payment model is therefore likely to mean that royalties will also be paid in instalments potentially spread over a number of years following treatment of a patient. While in practice this may not be a large change for licensors to adjust to (as annual payments for these high price treatments are not out of line with other orphan drug costs, most of which need to be taken over a long period of time) there are also other factors to consider.

One concern that has been raised with annuity payment models is that there may be an increased risk of non-payment as over time licensees may face difficulties in collecting payments, for example because a payer stops complying with payment schedules or becomes insolvent. This may have the knock-on effect of reducing royalties due to a licensor. Licensors may seek to reduce this non-payment risk by asking that royalties are payable on sums invoiced by a licensee, rather than sums received (although this is likely to be resisted by a licensee or perhaps only accepted with caveats). Annuity-based models are also typically more complicated and more expensive for a licensee to manage administratively and those costs are likely to be deductible from sales totals before a licensors royalties are calculated.

From a legal drafting perspective, care would also need to be taken by the licensor when defining payment terms and the royalty term (which is commonly linked to patent expiry) to ensure that the licensor continued to receive royalties in respect of patients who are treated within the royalty term, notwithstanding the fact that payment may not be received until after the patents and royalty term has expired.

Outcome-based model challenges

In relation to outcome-based models, a fundamental concern for both licensors and licensees is the uncertainty associated with a model which involves an upfront payment of the full treatment price but a refund payable some months or years down the line if the clinical outcomes are not met.

If royalties are payable on net sales of the therapy on a regular basis (e.g. quarterly or annually) then unless the licence includes a mechanism to take account of outcomes-based refunds made by the licensee to payers, the licensee could find itself out of pocket, unable to recover royalties paid to the licensor despite having had to refund the therapy price to the payer. To counter this risk, a licensee may seek to build in a royalty claw back mechanism into the licence, or to delay the point at which royalties are payable until after the relevant patient has met the required outcome. However, a licensor is unlikely to accept a significant delay in payment of royalties, particularly where the licensee has itself been paid. Academic licensors, with an obligation to invest income from technology transfer activities into research and the provision of education, are particularly unlikely to agree a royalty claw back structure which could force them to refund royalties or milestones a year or more after having received them.

One alternative option may be to agree that the licensee can make deductions against future royalty payments. A further alternative could be for some portion of the royalties paid to be retained in escrow for a period of time, to be released to the licensor upon achievement of a positive clinical outcome or expiry of a set period of time. However, escrow arrangements necessarily increase the complexity of agreements and are difficult to negotiate upfront when payment and reimbursement models and the associated outcome triggers have not yet been set.

A compromise?

As we have outlined in this article, although there are some things each party can consider at the outset of negotiating a licence, getting into protracted negotiations about hypothetical scenarios is unlikely to be attractive to either party.

The parties may wish to adopt an alternative approach of including robust governance provisions in the licence to deal specifically with this issue. For example, establishing a committee comprised of representatives of both parties to oversee and review issues relating to pricing and reimbursement. This may give the licensor a clearer oversight (and potentially input) into decisions which may impact future royalty streams and may present the licensee with an opportunity to propose alternative payment structures to support its desired pricing model. This could be combined with a mechanism for proposing and agreeing amendments to payment provisions in the licence if necessary to accommodate pricing and reimbursement issues which were unforeseen at the outset. Of course the success of such mechanisms will depend on the strength of the relationship between the parties and a combined willingness to work together and potentially compromise. It would also be important to ensure it is clear what happens where the parties cannot agree (e.g. escalation? expert determination? preservation of the status quo?). However, in a future where pricing and reimbursement issues are only likely to become more complex and of key importance to the success of complex treatments such as cell and gene therapies, it will be interesting to see whether this is a route industry explores.

Conclusion

The launch in recent years of a number of advanced cell and gene therapies with blockbuster price tags has heralded a new era for drug pricing and associated payment and reimbursement issues. It is a trend that looks likely to continue if current pipelines can also deliver much anticipated advanced therapies for common conditions. The high prices associated with these products present a myriad of issues however, not only for patients, payers and healthcare providers, but also for the licensors of the underlying intellectual property underpinning such treatments as industry adopts innovative new payment and reimbursement models which may impact on royalty streams.

When negotiating a licence to technology underpinning a cell or gene therapy the parties should consider how less conventional pricing mechanisms may impact the royalty structure. However, while there are some issues licensees and licensors may be able to consider upfront, it is difficult to anticipate the issues that may become relevant at a stage where pricing models have not been set, particularly as there is no one-size-fits-all pricing approach.

We have proposed an increased use of robust governance processes in a licensing relationship as one option to consider. It will also be interesting to see whether any trends emerge in relation to upfront and milestone payments in response to the challenges outlined above. In particular, licensees may push for more back-loaded or performance-related milestone payments to reflect the risks associated with pricing models which take a longer term view of the cost benefits of these types of therapies. We look forward to seeing what innovative approaches licensors and licensees adopt to adapt to these challenges in the years to come.

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Cell and gene therapies - Lexology

Diabetic Peripheral Neuropathy Market is Expected to Increase with a CAGR of 12% for the Study Period of 2017-2030: DelveInsight – P&T Community

LAS VEGAS, June 2, 2020 /PRNewswire/ -- Diabetic Peripheral Neuropathy Market will increase because of the rising global burden of diabetes that is driving prevalence of diabetic neuropathy, advancement in early diagnosis as well as launch of the promising therapies which will positively impact DPN market.

DelveInsight added a new report titled "Diabetic Peripheral Neuropathy MarketInsights, Epidemiology, and Market Forecast-2030" to its portfolio.

Key Highlights from Diabetic Peripheral Neuropathy Market report are:

Request for sample pages to know more onDiabetic Peripheral Neuropathy Epidemiology and Market Forecast

Diabetic Peripheral Neuropathy is a painful condition that is caused by nerve damage from diabetes. It is a common prevalent complication in neurological damage of Type 1 and Type 2 diabetes.

There is a huge patient population pool affected by the disease; the Diabetic Peripheral Neuropathy market report covers the disease epidemiology that is segmented into Total Diagnosed Prevalent Cases of DPN, Total Prevalent Cases of Painful DPN and Gender-specific Prevalent cases of DPN in the 7MM from 2017 to 2030.

The total Painful Diabetic Peripheral Neuropathy Prevalent Cases were 3,857,945 in the United States in 2020. Also, females are more affected by the disease as compared to males for Diabetic Peripheral NeuropathyPrevalent in the US in 2020.

Click here to know more onDiabetic Peripheral Neuropathypipeline

Among the 7MM, the US accounts for 58% of the overall market size of DPN. Among the EU-5 countries, Germany accounts for the highest market size for DPN. Diabetic Peripheral Neuropathy market has a diverse pipeline with several promising therapies. Also, Gene therapy has been developed for DPN pain management. Of the emerging therapies, the most anticipated product to get launched is VM202 Apart from this, other products include VM202 (Helixmith), NYX-2925 (Aptinyx), WST-057 (4% pirenzepine) (WinSanTor, Inc.), Ricolinostat (Regenacy Pharmacuticals), NRD.E1 (Novaremed Ltd.), Cebranopadol (Grnenthal GmbH), GRC 17356 (Glenmark Pharmaceuticals), and others are also expected to enter the market by 2030 as effective therapies. The potential launch of these emerging drugs will aid in overall market growth. There are a couple of market drivers which will be driving the market. One such factor will be an early diagnosis of the DPN because of the advancements happening in the DPN diagnostic approaches. As the patient pool for diabetic peripheral neuropathy is quite large, and there is no treatment for reversal of disease, this indication withholds a plethora of opportunities for drug development companies. No doubt that the clinical pipeline contains a large number of drugs; however, previously multiple clinical trial failures gave a setback and limited the research and development in the DPN domain. So far it has been clear that path traversed is not easy in DPN research as the long-term clinical trials and low success rate in meeting the clinical endpoints may become threats for the investors to fund further.

There aremany key players robustly involved in developing potential drugs and they are a ray of hopefor DPN patients such as:1. VM2022. NYX-29253. WST-0574. Ricolinostat5. ISC 175366. NRD135S.E17. Cebranopadol8. GRC 173569. MEDI735210. Trazodone/GabapentinAnd many others

The key players involved in Diabetic Peripheral Neuropathy market are:1. Helixmith2. Aptinyx3. WinSanTor, Inc4. Regenacy Pharmacuticals5. Ichnos Science6. Novaremed7. Grnenthal GmbH8. Glenmark Pharmaceuticals9. AstraZeneca10. AngeliniAnd many others

The reasons for buying Diabetic Peripheral Neuropathy market report:

Table of contents

1. Key Insights

2. Executive summary

3. Diabetic Peripheral Neuropathy Market Overview at a Glance

4. Diabetic Peripheral Neuropathy Epidemiology and Market Methodology

5. Diabetic Peripheral Neuropathy Disease Background and Overview

6. Diabetic Peripheral Neuropathy Epidemiology and Patient Population

6.1. Key Findings

6.2. Total Diagnosed Prevalent cases of Diabetic Peripheral Neuropathy in 7MM

6.3. United States

6.4. EU5

6.5. Germany

6.6. France

6.7. Italy

6.8. Spain

6.9. United Kingdom

6.10. Japan

7. Diabetic Peripheral Neuropathy Treatment and Management

8. Diabetic Peripheral Neuropathy Unmet need

9. Diabetic Peripheral Neuropathy Marketed Drugs

9.1. Key cross competition

9.2. Qutenza: Grnenthal

9.3. Tarlige: Daiichi Sankyo

10. Diabetic Peripheral Neuropathy Emerging drugs

10.1. Key cross competition

10.2. VM202: Helixmith

10.3. NYX-2925: Aptinyx

10.4. WST-057: WinSanTor

10.5. Ricolinostat: Regenacy Pharmaceuticals

10.6. Cebranopadol: Grnenthal

10.7. ISC 17536: Ichnos Science

10.8. NRD135S.E1: Novaremed

10.9. MEDI7352: AstraZeneca

10.10. Trazodone/Gabapentin: Angelini

11. Diabetic Peripheral Neuropathy Market Size

11.1. Key Findings

11.2. Total Market Size of Painful Diabetic Peripheral Neuropathy in 7MM

11.3. Diabetic Peripheral Neuropathy Market Outlook: 7 MM

11.4. United States

11.5. EU5

11.6. Germany

11.7. France

11.8. Italy

11.9. Spain

11.10. United Kingdom

11.11. Japan

12. Diabetic Peripheral Neuropathy Reimbursement policies

13. Market Drivers

14. Market Barriers

15. SWOT Analysis

16. KOL Views

17. Diabetic Peripheral Neuropathy Case Report

18. A Case Report of Diabetic Peripheral Neuropathy

19. Bibliography

20. Appendix

21. Diabetic Peripheral Neuropathy Report Methodology

22. DelveInsight Capabilities

23. Disclaimer

24. About DelveInsight

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Related Reports:

Diabetic Peripheral Neuropathy Epidemiology Forecast-2030 report delivers an in-depth understanding of the disease, historical, forecasted epidemiology trends of DPN in the 7 MM.

Diabetic Peripheral Neuropathy Pipeline Insight, 2020 report by DelveInsight outlays comprehensive insights of present clinical development scenario and growth prospects across the Diabetic Peripheral Neuropathy market.

About DelveInsight

DelveInsight is a premier Business Consulting and Market Research firm, focused exclusively on the life science segment. With a wide array of smart end-to-end solutions, the firm helps the global Pharmaceutical, Bio-Tech and Medical devices companies formulate prudent business decisions for improving their performances to stay ahead of the competitors.

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Shruti Thakurinfo@delveinsight.com+91-9650213330DelveInsight

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Diabetic Peripheral Neuropathy Market is Expected to Increase with a CAGR of 12% for the Study Period of 2017-2030: DelveInsight - P&T Community

Concise Report 2020: Gene Therapy Market Competitive Landscape and Industrial Growth| The Impact of COVID-19 Disruption During 2029 – News Distinct

Worldwide Gene Therapy Market, [Forecast 2020-2029] Succinct Study Report is in-depth survey on the current state of the global Gene Therapy industry with focus on short term and long term impact analysis of COVID-19/CORONAVIRUS. The report provides key statistics on the market status of the Gene Therapy manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.

The Gene Therapy Market report covers detailed competitive outlook including the market share and company profiles of the key participants operating in the global market. Vital key players profiled in the report include Novartis, Kite Pharma Inc, GlaxoSmithKline PLC, Spark Therapeutics Inc, Bluebird bio Inc, Genethon, Transgene SA, Applied Genetic Technologies Corporation, Oxford BioMedica PLC, NewLink Genetics Corp., Amgen Inc. Company profile includes assign such as company summary, SWOT analysis and current developments, financial summary, product specifications, production value, business strategy and planning. This report analyzes the top players in global market, and splits the Gene Therapy market by vector type, gene type, application, and region.

|| Access insightful study with over 100+ pages, list of tables & figures, profiling 10+ companies. Ask for Free Sample Copy(PDF) @https://marketresearch.biz/report/gene-therapy-market/request-sample

Through the statistical analysis, the report depicts the global total market of the Gene Therapy industry including capacity, production value, cost/profit, supply/demand, production and import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis. The report then estimates the 2020-2029 market development trends of the Gene Therapy industry. Analysis of upstream raw materials, downstream demand and current market dynamics is also carried out in this report.

In the end, the report makes some important proposals for a new project of the Gene Therapy Industry before evaluating its feasibility. Overall, the report provides an in-depth insight into the 2020-2029 global Gene Therapy industry covering all important parameters.

The Final Report will cover the impact analysis of COVID-19 on this industry (Global and Regional Market).

>>>>Download Here- Short Term & Long Term Impact Analysis of Gene Therapy Market<<<<

Promising Regions & Countries Mentioned In The Gene Therapy Market Report:

North America (U.S. & Canada)

Latin America (Brazil, Mexico, Argentina, Rest of Latin America)

Europe (U.K., Germany, France, Italy, Spain, Hungary, Belgium, Netherlands & Luxembourg, NORDIC, Poland, Turkey, Russia, Rest of Europe)

Asia-Pacific (China, India, Japan, South Korea, Indonesia, Malaysia, Australia, New Zealand, Rest of Asia-Pacific)

The Middle East and Africa (Israel, GCC [Saudi Arabia, UAE, Bahrain, Kuwait, Qatar, Oman], North Africa, South Africa, Rest of The Middle East and Africa)

Years Considered For This Report:

Historical Years :2013-2018

Base Year :2019

Estimated Year :2020

Forecast Period: 2020-2029

A complete value chain of the global Gene Therapy Market is presented in the research report. It is associated with the review of the downstream and upstream components of the Gene Therapy Market. The market is bifurcated on the basis of the categories of products and the customer application segments. The market analysis demonstrates the expansion of each segment of the global Gene Therapy Market. The research report assists the user in taking a decisive step that will be a milestone in developing and expanding their businesses in the global Gene Therapy Market.

For any special requirements about this report[Click Here- For Enquiry & Report Customization]please let us know and we can provide custom reports.

Key Answers Captured in Report?

Which geography would have better demand for products/services?

What are the strategies adopted by big players in the regional market?

Which country would see the steep rise in CAGR & year-on-year (Y-O-Y) growth?

What is the current & expected market size in the next five years?

What is the market feasibility for long term investment?

What opportunity the country would offer for existing and new players in the market?

What is the risk involved for suppliers in the geography?

What factors would drive the demand for the product/service in the near future?

What is the impact analysis of various factors in market growth?

There Are 13 Chapters To Thoroughly Display The Gene Therapy Market:

Chapter 1:Global Gene Therapy Market Overview, Product Overview, Market Segmentation, Market Overview of Regions, Market Dynamics, Limitations, Opportunities and Industry News and Policies.

Chapter 2:Global Gene Therapy Market Chain Analysis, Upstream Raw Material Suppliers, Major Players, Production Process Analysis, Cost Analysis, Market Channels and Major Downstream Buyers.

Chapter 3:Value Analysis, Production, Growth Rate and Price Analysis by Type of Gene Therapy.

Chapter 4:Downstream Characteristics, Consumption and Market Share by Application of Gene Therapy.

Chapter 5:Production Volume, Price, Gross Margin, and Revenue ($) of Gene Therapy by Regions (2013-2020).

Chapter 6:Gene Therapy Production, Consumption, Export and Import by Regions (2013-2020).

Chapter 7:Gene Therapy Market Status and SWOT Analysis by Regions.

Chapter 8:Global Competitive Landscape, Product Introduction, Company Profiles, Market Distribution Status by Players of Gene Therapy.

Chapter 9:Gene Therapy Market Analysis and Forecast by Type and Application (2020-2029).

Chapter 10:Global Market Analysis and Forecast by Regions (2020-2029).

Chapter 11:Global Industry Characteristics, Key Factors, New Entrants SWOT Analysis, Investment Feasibility Analysis.

Chapter 12:Market Conclusion of the Whole Report.

Chapter 13:Appendix Such as Methodology and Data Resources of This Research

....For Detailed InformationClick Here For Complete TOC

Why MarketResearch.Biz?

Robust research methodology of Gene Therapy market

Technically renowned study with overall Gene Therapy industry know-how

Focus on Gene Therapy drivers, restraints, opportunities, and threats till 2029

Based on complete research, we offer the clear view of real Gene Therapy market scenario and help clients with making an important business judgment

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Concise Report 2020: Gene Therapy Market Competitive Landscape and Industrial Growth| The Impact of COVID-19 Disruption During 2029 - News Distinct

Global Gene Therapy Market Size to Expand Significantly by the End of 2025 – Cole of Duty

The report titledGlobalGene TherapyMarketpresents a much-awaited study on the global market which summarizes the market in terms of definitions, applications, types, and leading key players/manufacturers ofGene Therapyindustry. The report comprises insights related to the present scenario of the market and the industry scenario over the forecast time-span from 2020 to 2025. The report reveals a comprehensive study on market dynamics including drivers, restraints and opportunities, recent trends, and industry performance analysis, and detailed value chain assessment. It features global and regional data and over top key players profiles, this report gives the guide to exploring opportunities in theGene Therapyindustry. The report is partitioned based on driving players, applications, and regions.

NOTE: This report takes into account the current and future impacts of COVID-19 on this industry and offers you an in-depth analysis of GlobalGene TherapyMarket.

DOWNLOAD FREE SAMPLE REPORT:https://www.fiormarkets.com/report-detail/376052/request-sample

About The Industry:

The previous, current market situation, and prospects of the market are examined. The comprehensive competitive analysis section includes detailed profiling of leading manufacturers operating in the global market. Highlights of the segmentation study covered in this report include price, revenue, sales, sales growth rate, and market share by product. It enfolds insightful analysis of competition intensity, segments, environment, and product innovations to provide deep comprehension of the completeGene Therapymarket environment. An extensive analysis of market-changing market trends, driving factors, growth potentials, investment opportunities, threats, and restraints has been given in the report.

Top companies profiled in this report include:Spark Therapeutics LLC, Bluebird Bio, UniQure N.V., Juno Therapeutics, GlaxoSmithKline, Chiesi Farmaceutici S.p.A., Bristol Myers Squibb, Celgene Corporation, Human Stem Cell Institute, Voyager Therapeutics, Shire Plc, Sangamo Biosciences, Dimension Therapeutics and others.

The report is a professional and comprehensive research report on the worlds major regional market conditions, focusing on the main regions:North America, Europe, Asia Pacific, South America, and the Middle East and Africa.

Moreover, the report is presented in an efficient way that involves basic terminology, a basic outline, agreements, and certain facts as per comprehension. Clients needs ensure a thorough understanding of market capacities. It provides market-driven results deriving feasibility studies for client needs. The report presents an overview of key marketing strategies and key sales channels adopted in the globalGene Therapymarket.

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Analysis of Key Aspects Covered In TheGene TherapyMarket Report:

Industry Scenario: Definitions, classifications, applications, and globalGene Therapymarket overview; product specifications; manufacturing processes; cost structures, raw materials

Key Market Dynamics: The report includes production strategies and methodologies, development platforms, and the product model. The latest market trends, development outlines, and research methodologies are provided for the projected period.

Competitive Landscape: The competitive analysis involves the market share of major players, along with the new projects and strategies adopted by players in the past five years. Comprehensive company profiles cover the product

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs.

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Global Gene Therapy Market Size to Expand Significantly by the End of 2025 - Cole of Duty

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