An Australian court on Friday dismissed a challenge against the patenting of human genetic material in a landmark case which has devastated a cancer group that says it could stifle research.

The case hinged on whether a valid patent can be granted to cover naturally occurring nucleic acids, the building blocks of living organisms -- in this case the so-called breast cancer gene BRCA1.

Federal Court Justice John Nicholas rejected the argument that BRCA1, a genetic mutation associated with an increased risk of breast and ovarian cancer in women, could not be patented because it was a naturally occurring substance.

He ruled instead in favour of the two medical research companies that hold the patent, US-based Myriad Genetics and Melbourne-based Genetic Technologies Ltd.

"There is no doubt that naturally occurring DNA and RNA as they exist inside the cells of the human body cannot be the subject of a valid patent," his judgement concluded. DNA and RNA are types of nucleic acid.

"However, the disputed claims do not cover naturally occurring DNA and RNA as they exist inside such cells.

"The disputed claims extend only to naturally occurring DNA and RNA which have been extracted from cells obtained from the human body and purged of other biological materials with which they were associated."

The decision is the first in the country to consider whether isolated DNA or RNA sequences can be patented and lawyers for Cancer Voices Australia, which brought the case, have argued it raises ethical issues about the commercialisation of the human body.

The judgement is a blow to the cancer campaigners, with the woman who brought the case, Yvonne D'Arcy, leaving the court in tears.

"To tell the truth I'm very disappointed," she told reporters. "We were doing this for future generations, and I'm just so disappointed."

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Challenge to cancer gene patent fails in Australia

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Gangnam Style --University of Chittagong ( Genetic Engineering Dept.)
Gangnam Style- University of Chittagong...It was performed at the Freshers Graduation Festival 2013 of Dept. of Genetic Engineering Biotechnology, University of Chittagong

By: arian orko

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Bio Ethics,genetic engineering,and babies
http://www.youtube.com if you care so much about babies but not enough about making their lives easier their genetic engineering then well you don #39;t really care about them now do you?

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NEW YORK The increasing power and accessibility of genetic technology may one day give parents the option of modifying their unborn children, in order to spare offspring from disease or, conceivably, make them tall, well muscled, intelligent or otherwise blessed with desirable traits.

Would this change mean empowering parents to give their children the best start possible? Or would it mean designer babies who could face unforeseen genetic problems? Experts debated on Wednesday evening (Feb. 13) whether prenatal engineering should be banned in the United States.

Humans have already genetically modified animals and crops, said Sheldon Krimsky, a philosopher at Tufts University, who argued in favor of a ban on the same for human babies. "But in the hundreds of thousands of trails that failed, we simply discarded the results of the unwanted crop or animal."

Unknown consequences

Is this a model that society wants to apply to humans, making pinpoint genetic modifications, only to "discard the results when they don't work out?" Krimsky asked during an Intelligence Squared Debate held in Manhattan. He added that assuming no mistakes will occur would be sheer hubris.

He and fellow ban proponent Lord Robert Winston, a professor of science and society and a fertility expert at Imperial College in London, focused on the uncertainty associated with the genetic underpinnings of traits. The two also addressed the consequences of manipulating genes. [5 Myths About Fertility Treatments]

"Even [for] height, one of the most heritable traits known, scientists have found at least 50 genes that account for only 2 to 3 percent of the variance in the samples," Krimsky said. "If you want a tall child, marry tall."

Mother Nature doesnt care

Meanwhile, their opponents, who opposed the ban, talked of empowering parents to give their children a healthy life, even if it meant giving their offspring traits they themselves could not pass down.

Lee Silver, a professor of molecular biology and public policy at Princeton University, urged the audience members to look at someone sitting next to them.

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Indian scientists have reported subtle genetic changes called 'lineage shifts' in a predominant dengue strain

James Gathany/Wikicommons

[NEW DELHI] Scientists have reported subtle genetic changes in the dominant dengue virus strain in southern India information that has been lacking so far and could be crucial to understanding disease severity.

Dengue, spread by mosquitoes, is prevalent in tropical countries, affecting 100 million people each year. A sharp rise in incidence and severity in recent years has been attributed to increased air travel, urbanisation, deteriorating public health infrastructure and changing climate.

Of the four strains of the dengue virus, the third one ('DENV 3') has dominated recent outbreaks in the Indian sub-continent. The genetic material of viruses belonging to each strain is not 100 per cent identical and minor variations can be traced to a common ancestor or 'lineage'.

Minor changes in the genetic material from one lineage can result in resemblance to viruses from another lineage and such lineage shifts are linked to "dramatic increases" in dengue severity in many parts of the world, say researchers in the Virology Journal published on 29 January.

The researchers, from the southern Indian state of Kerala where dengue re-emerged as an epidemic in 2003 leading to numerous deaths, studied samples of the third strain collected from over 700 patients in the state, between 2008 and 2011. They compared the data with other Indian and global studies and reported a lineage shift (from lineage III to lineage IV) for the first time.

Lineage shift is reflected in changes to virus functions, such as increased or decreased virus multiplication. This, in turn, affects the spread of the virus or the number of people infected during an outbreak, Easwaran Sreekumar, from the viral disease biology programme at the Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, and one of the authors of the paper, explained to SciDev.Net.

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Dengue virus strain shows subtle genetic changes

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Feb. 15, 2013 Researchers don't know the exact cause of Behet's disease, a chronic condition that leads to oral and genital sores and serious complications such as blindness, but new research brings better understanding to what makes some people more susceptible to being affected.

In one of the most extensive genetic analyses of Behet's disease, a University of Michigan-led, international team of researchers has identified novel gene variants in the inflammatory disorder and uncovered data that could apply to studies of other diseases. The results appear in the journal Nature Genetics.

"This disease is associated with significant complications and because it is not well understood, treatment options are limited," says lead author Amr Sawalha, M.D., associate professor of internal medicine in the division of rheumatology at the U-M Medical School.

"We were able to identify and localize robust genetic risk factors associated with Behet's disease in a way that will hopefully bring us a step closer to better understanding this devastating illness."

The UMHS research, a collaboration that includes researchers from Turkey, Italy, Germany and the Netherlands, identifies how a specific group of genes are linked to Behet's disease. The disease can affect people from all ethnicities, but has an increased prevalence along the ancient "Silk Road" in East Asia, Turkey, and the Mediterranean and Middle Eastern countries.

The disorder causes chronic inflammation in blood vessels throughout the body and affects many organs, including the eyes, brain, skin, joints and the digestive system. Some symptoms may include mouth and genital ulcers, eye inflammation and reduced vision, skin rashes and lesions, joint swelling, abdominal pain and diarrhea.

Behet's disease may also cause inflammation in the brain, which could cause headaches, fever, poor balance or stroke. Inflammation in veins and large arteries could also lead to other complications, such as aneurysms.

One of the major genetic risk factors of the disease is believed to be a specific form of a gene on chromosome 6 in the HLA region (an inherited group of genes known as human leukocyte antigen).The new study shows that contrary to the belief that genetic risk in this region is most strongly tied to a form of the gene HLA-B (called HLA-B*51) -- there are actually at least four independent genetic risk regions within the HLA linked to the disease.

Researchers have long studied the phenomenon of why certain forms of HLA are associated with autoimmune and inflammatory disorders and the severity of those disorders.

"This HLA region has an incredibly significant role in many diseases. It's also one of the most complicated areas of the human genome, which is why it's so difficult to analyze," Sawalha says. "This is an extensive way to look at the HLA region that can be also applied to other diseases. We can now identify and localize the risks within this complex HLA region more accurately than ever before, which opens the door to further developments."

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New findings on genetic risks of Behçet's disease

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Feb. 18, 2013 Genetic medicine experts from Manchester Biomedical Research Centre at Saint Mary's Hospital and The University of Manchester have identified a new gene responsible for causing an inherited form of tumour, known as spinal meningioma. Meningiomas are the commonest form of tumour affecting the brain and spine. Usually meningiomas can be removed by surgery and do not recur. Occasionally people can develop more than one meningioma or many members of the same family can be affected.

A team led by Dr Miriam Smith, Professor Gareth Evans and Dr Bill Newman worked with families with a history of meningiomas affecting the spinal cord. Using a powerful new genetic sequencing technique called next generation sequencing, they were able to check all the genes of three individuals with multiple spinal meningiomas. This lead to the identification that changes in a gene called SMARCE1 lead to spinal meningiomas in some families.

In December 2012 the government announced a focus on genetic sequencing with an aim of sequencing the genomes (a person's DNA) of 100,000 Britons with cancer and rare diseases in UK centres. The voluntary sequencing of patients will lead to better testing, better drugs and above all better care for patients. Manchester is already using this technology in their well established Genetics department at Saint Mary's and it is enabling doctors to ensure patients have access to the right drugs and personalised care quicker than ever before.

In the past year 10 genes have been discovered using the new next generation sequencing technology in Manchester including genes for developmental problems, deafness, short stature and bladder problems that lead to kidney failure.

"With our new DNA sequencing machines, we have been able to show that changes in the SMARCE1 gene are responsible for multiple spinal meningioma disease," said Dr Smith. "Before our work, doctors did not know that inherited spinal meningiomas have a completely different cause to other tumours affecting the brain and spine.

"The next step is to develop a screening programme to assess the risk of developing spinal tumours for individuals in affected families, and to investigate possible treatments to prevent the spinal tumours from growing."

Professor Richard Marias, Director of Cancer Research UK's Paterson Institute at The University of Manchester, said "This research highlights the complexity of tumour diagnosis. Such detailed molecular characterisation underpins current thoughts about how meningioma and cancer will be managed in the future and is at the heart of the personalised medicine approach." Just over two people in every 100,000 develop meningiomas in the head and spine, with twice as many women as men diagnosed with the condition.

The team's pioneering work was funded by The Children's Tumor Foundation, a US-based charity supporting neurofibromatosis research, and the Association for International Cancer Research, a global cancer research charity.

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Genetic key to preventing spine tumors

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Fitness Model Journey Ep2 - First World Problems
Add Me Facebook.com/EricBergePT Injury Check Up, Genetics, Diet....i keep getting sick is the biggest challenge... grr HELL ( Original Mix ) By CENOB1TE Discord ( At Dawn We Rage Remix ) Destroy ( Midnight Conspiracy Remix ) soundcloud.com creativecommons.org

By: Eric Berge

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Fitness Model Journey Ep2 - First World Problems - Video

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What Stems Cancer Cells? The discovery of a new cancer stem cell marker
Excited about stem cells? Want to learn how stem cells influence cancer growth? Learn how scientists are paving the way to a better understanding of the identity and behavior of cancer stem cells! For more exciting science videos, visit Youreka Science: http://www.yourekascience.com Original article: "Dclk1 distinguishes between tumor and normal stem cells in the intestine." Nakanishi et al. Nature Genetics, Jan 2013

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Fruit Fly Harlem Shake
Genetics nerds from Kyiv, Ukraine present you Drosophila melanogaster HARLEM SHAKE!

By: sombra145b

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Fruit Fly Harlem Shake - Video

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Cataclysm: DDA - Character 2, Part 3: Lasers and Wolves
I continue on from the house in the middle of the woods, explore a lab, and head down the road. I really should have taken the robust genetics trait.

By: Yobihodazine

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Cataclysm: DDA - Character 2, Part 3: Lasers and Wolves - Video

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Lot3 832
Homestead Genetics Bucking Bull Sale March 30th

By: Summerrain411

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Lot3 832 - Video

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Lot 3 832 vid 2
Homestead Genetics Bucking Bull Sale March 30th

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Lot 8 0246
Homestead Genetics March 30th 2013 bull sale

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0246lot8
Homestead Genetics March 30th 2013 bull sale

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Boost: The Web Series - Official Teaser
The plot centers around Victor Blaine, a neurologist hired by a secret government organization called "Division" for his work and expertise in genetics, neuroscience and evolutionary psychology. Blaine had spent years developing a way to improve the cognitive functions of the brain after the boom of technology. Working on a serum (self proclaimed as "Boost") during the first animal test subject Blaine #39;s Boost project took an unexpected turn, discovering that the serum gave users extraordinary abilities. Division arranged for their first human test subject using the Boost prototype on "Elliot Fox" a former ex convict. The test proved to be successful however upon further observation over the course of 24 hours, Blaine had discovered that users of Boost developed a dependency on the drug and withdrawal from it caused violent aggression and paranoia in the subjects. Division had urged Blaine to fix the problem, when Blaine refused out of fear that the drug was too dangerous to carry forward. Division threatened to go after Blaine #39;s family. Blaine spent the next few years trying to perfect Boost all while trying to uncover who exactly his mysterious employers were. One night, Blaine accidentally stumbles upon some important data revealing that Division is actually a cult set on destroying the world and creating their own utopia. Blaine steals the data and destroys all the newly developed data of the Boost project and goes into hiding. Years later Elliot Fox is recruited by ...

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Boost: The Web Series - Official Teaser - Video

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Bella, officially barefoot!
http://www.formspring.me instagram: kpontone One of the most incredible experiences I #39;ve ever had. I #39;m so thankful that my trainer allowed Bella to have the opportunity to be successfully barefoot! I still am leasing Bella so she did not have to let Bella have this opportunity, but I am so glad she did and once you see how Bella moved, you will be as stunned as I was! Truly amazing and certainly eye-opening! Blood in the white line due to diet issues and classified as subclinical or low level laminitis. Meaning inflammatory triggers in the diet cause the bleeding Will have a video of Bella #39;s movement up tomorrow. It is astonishing! Very cool to see "genetics" change! You can even see her genetics change just in the jog! She is moving comfortably and like a normal horse! Honestly never thought it was possible, but nature showed me how it #39;s done! I #39;m so excited to get down the lines now that she #39;s not going up and down out of pain anymore! Amazing what can happen when you give your horse the opportunity to be barefoot! Every horse deserves to be barefoot!

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Bella, officially barefoot! - Video

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The Genetics Underground V5
2 minute still frame pictures told in a sci-fiction narrative. Plot Synopsis: In the year 2030, the government has regulated the birth of humans. A fetus must pass a genome test to determine if it meets the qualifications of a good human specimen. As one woman tries to have a child, her off-springs keep failing the genome test. After several trials, she turns to more drastic measures in order to have a child of her own. Special Thanks to my group from DC 461 and our last minute actors.

By: Candida87LNL

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The Genetics Underground V5 - Video

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WAYS TO LOSE BELLY FAT WITH THE FAT LOSS FACTOR
WAYS TO LOSE BELLY FAT WITH THE FAT LOSS FACTOR eb2c96sinhmiau5cz8jfvckho6.hop.clickbank.net This is about one of the most exciting weight loss programs in America. The goal is to help you get a flatter belly while you still enjoy some of the foods you love. Before and after pictures and measurements show that some people lose belly fat the very first week they participate in the program. Many people are losing weight for the first time, and keeping the weight off.....This diet is the opposite of crash diets that put the body in starvation mode, causing a loss of muscle instead of fat. This diet helps people overcome genetics. Participants are taught how to lose weight while they still eat many of the so called "bad foods." There are some people using the Fat Loss Factor who are not successful, only because they do not follow the step by step directions. WAYS TO LOSE BELLY FAT WITH THE FAT LOSS FACTOR There are no supernatural berries and other scams in this diet. The inventors of this method believe that we do not get fat because we ate too many bad foods. They are experts in nutrition and wellness. Losses of up to 8 pounds in 9 days have been reported using this method, called the Fat Loss Factor. People are losing fat from their arms, legs, thighs and bellies...The liver is one of the keys to losing weight. The job of the liver is to break down toxic substances, and transfer fat throught the body. The first step of the Fat Loss Factor program is to purify the body ...

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WAYS TO LOSE BELLY FAT WITH THE FAT LOSS FACTOR - Video

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Gene-therapy hope for East Lancashire woman with rare growth syndrome

12:00pm Monday 18th February 2013 in News By Jessica Cree, Ribble Valley reporter

Mandy Sellars hopes gene therapy will help shrink her legs

A WOMAN battling a rare condition in which she has 17-stone legs is hoping a new gene therapy will reverse the growth.

Mandy Sellars has a condition similar to Proteus Syndrome, the same condition that affected Elephant Man Joseph Merrick, which causes skin overgrowth and and abnormal bone development.

But the 38-year-old, who is originally from Bacup and now lives in Huncoat, is undergoing revolutionary gene therapy in Cambridge which she hopes will stop her legs from growing and even cause them to shrink back to a normal size.

She is to appear on a Channel 5 programme tonight which will document her progress and investigate the new treatment.

Mandy, who lives in Bolton Avenue, said: I have been doing quite well since the doctor found the gene therapy and I started taking some medication that they think will work.

I am a bit like a guinea pig and we want to see if the medication may help other people.

I never thought it would happen in my lifetime so it is fantastic news.

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Gene-therapy hope for East Lancashire woman with rare growth syndrome

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Eddie G. Spinal Cord Injury Treadmill training at Pressing On
http://www.presssingontx.org - Pressing On client Eddie is a spinal cord injury/stroke/brachial plexus injury and traumatic brain injury. He has come a long way. This clip show him on the treadmill, pedaling a bike and pushing the elliptical at Pressing On. Like us on facebook at http://www.facebook.com/pressingontx

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Eddie G. Spinal Cord Injury Treadmill training at Pressing On - Video

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Beckers Muscular Dystrophy After Stem Cell Therapy in Mumbai India
He is a 12 year old and a known case of BMD with history of gradual onset of progressive lower extremities muscle weakness since age of 7 years with complaints of difficulty in climbing stairs, getting up from floor. Weakness even progressed to upper extremities with difficulty in overhead activities and frequent falls. No family history. On examination, he has grade 3 #713; muscle power in proximal muscles of both upper extremities and lower extremities and 4 in distal muscles of both upper extremities and lower extremities. He has bilateral pseudohypertrophy of calf muscles and walks on toes. Neurologically, he is hypotonic and hyporeflexic. Functionally, he is independent in most of the ADL, needs assistance in lower body dressing. On FIM he score 109. After Stem Cell Treatment 1. Reports overall feeling of freshness and energetic. 2. Can manage to walk on heels. Earlier he would walk on toes. 3. Posture has improved. Earlier he would walk with lordosis. 4. Earlier he would need maximum support for stair climbing from both railing and one hand on knee, now only uses railing to climb stairs. 5. Stamina has improved and he has increased level of confidence. 6. Sit to stand and stand to sit transfers requires less efforts. 7. Can perform overhead activities with ease and maintains for a longer time. 8. Is more active than before. 9. Speech is clear and loud followed by deep inhalation and slow rate with prolongation technique. 10. Secondary behaviors also reduced like reduced ...

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Beckers Muscular Dystrophy After Stem Cell Therapy in Mumbai India - Video

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Hypoxic Ischaemic Brain Injury Improvement After Stem Cell Therapy in Mumbai India
He is a case of Hypoxic Brain Injury since 4 years. Because of high grade fever of "chikungunya", he got cardiac arrest and went into coma for 1 year. During comatose stage, he had sacral and Greater Trochanter sores which are all recovered and he has developed myositis ossification at bilateral hip and right elbow. Hip myositis ossification was removed surgically. After comatose stage, he has recovered in speech and voluntary control. He has developed rigidity in trunk and lower extremities. In 2011,he had history of fall while walking and had right femur shaft fracture which was treated surgically with plate and screws in place. Neurologically, he is hypertonic and hyperreflexic. On examination, he has restricted range of motion of bilateral hip, knee and ankle and right elbow. Voluntary control of lower extremities is poor while voluntary control of upper extremities is fair. He has rigidity in bilateral lower extremities and spasticity of grade 2 in upper extremities muscles. Patient is dependent for all ADL. On FIM he scores 30. After Stem Cell Treatment 1. He feels ease in getting up from supine to sit. 2. He can sit straight for some time (5-10 minutes) ,earlier easily stoop in 5-10 seconds. 3. His sitting balance is improved than before, earlier had fear to tilt sideways. 4. His spasticity in lower limb has reduced. 5. His speech has become clear and with proper pauses. 6. He can do roll over on bed with ease and less assistance from caretaker than before. Stem ...

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Inclusive Body Myopathy Improvement After Stem Cell Therapy in Mumbai India
He is a case of Inclusive Body Myopathy, since last 16 years with the history of slowness in running speed and slipping of "chappals" while walking and following foot drop. Weakness is progressive in nature and now involved muscles of all 4 limbs and trunk. Since last 3 years he is bedridden. Muscle biopsy is showing Inclusive Body Myopathy and EMG-NCV reports are showing generalized primary muscle disease. His elder sister also suffering from the same problem. Neurologically, he is hypotonic and hyporeflexic. On examination: he has grade 1+ muscle power in all 4 limbs proximally and grade 0 foot muscles and grade 3 distal muscles of upper limbs. Proximal muscle weakness is more than distal. Functionally, he is dependent in all ADL and mobility. On FIM he scores 48. After Stem Cell Treatment 1. Stamina has increased. 2. He can do suspension exercises for more range of motion and with more repetition without fatigue. 3. Now he can initiate rolling. He takes less support for rolling and turning. Earlier he used to change his position 4-5 times because of discomfort, but now he needs to change his position only once at night. 4. He can initiate supine to sit. 5. He is able to perform side lying to sitting by himself upto 70%. 6. Attempted drinking water in modified manner with right hand, which he couldn #39;t do before. Stem Cell Therapy done at Dr Alok Shrama NeuroGen Brain and Spine Institute Surana Sethia Hospital Sion-Trombay Rd, Suman Ngr Opp Corporate Park, Chembur ...

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Inclusive Body Myopathy Improvement After Stem Cell Therapy in Mumbai India - Video

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Autism Improvement After Stem Cell Therapy in Mumbai India
He is a known case of Autism with history of full term normal delivery, cried immediately after birth. He had near normal motor milestones with delayed speech. On examination, he has poor eye contact, poor concentration, poor attention span, poor language command. He is stubborn and aggressive (decreased with rehabilitation). He goes to normal school and had good memory but poor in social communication. On ISAA scale he scores 90. On WeeFIM, he scores 77. After Stem Cell Therapy Psychology assessment: 1) His attention and concentration has improved by 25%. Previously his remedial educator would take him in a group session as he would do an activity only under a competitive spirit whereas now he can even study alone. 2) Eye contact has improved. 3) His quantity and quality of vocabulary has improved about 25%. 4) Now, he is able to form sentences of 4-5 words whereas previously his speech was bisyllables. 5) Now he is able to formulate meaningful sentences and have a meaningful conversation. 6) Now he is learning new mathematical concepts and mother and teachers feel that study wise there are real good improvements. 7) Memory has improved ie now he is able to reproduce and recollect whatever has been taught to him in the school. 8) Speech therapist mentioned that he now does not require speech therapy whereas he now requires OT and remedial education. 9) Social interaction is better ie now he can initiate and engage himself and other people into an activity or conversation ...

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Autism Improvement After Stem Cell Therapy in Mumbai India - Video

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