GNDU jashan 2013 giddha by social science dept.

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Richard McGee, M.D.
Dr. Richard McGee is a medical oncologist and hematologist at the Swedish Cancer Institute. His special interests are in cancer research, advances in cancer ...

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Runescape 2007 | B0aty - First PK Trip !
2000 for my return to RuneScape PKing? ;D I #39;m absolutely so happy with this 🙂 Possibly the best first video i could of uploaded, unfortunately i #39;m not that...

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Runescape 2007 | B0aty - First PK Trip ! - Video

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More Mobs Minecraft Ep 6- DNA!
There was a bit of a problem with this world and the update to 1.5. I am working on fixing the problem but I have a feeling I might have to wait for the mods...

By: UnprofessionalGam3rs

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More Mobs Minecraft Ep 6- DNA! - Video

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Dance Your Heart Away with Vehllia - Happiness Muscles

By: Kim Beasley

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Losing Fat on Lower Abs Stomach
Thanks for the support! Please LIKE and COMMENT if you enjoy! #9675; Top 5 Bodybuilding Snacks: http://youtu.be/s0CLtvWk3dc #9675; Six Pack Abs Workout: http://youtu.b...

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Losing Fat on Lower Abs

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Workout 1

By: Tara Nik-Khah

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YOU CAN #39;T BEAT ME! (The Hidden)
Enjoy the video? Subscribe! http://bit.ly/M0mU1V #9669; #9669; #9669; Want some gear? US Store: http://seananners.spreadshirt.com EU Store: http://seananners.spreadshirt....

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Can I Get Rid of "Gyno"?
Sign up Grow Stronger Newsletter: http://hulsestrength.com/go/youtube Elliott #39;s Other Channel: http://www.youtube.com/user/elliottsaidwhat Elliott #39;s Facebook...

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MIND GAMES (The Hidden)
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MIND GAMES (The Hidden) - Video

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Carbing Up Before Bed?
Sign up Grow Stronger Newsletter: http://hulsestrength.com/go/youtube Elliott #39;s Other Channel: http://www.youtube.com/user/elliottsaidwhat Elliott #39;s Facebook...

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Carbing Up Before Bed? - Video

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Outdoor Kettlebell Workout (while camping with my kids)
Sign up Grow Stronger Newsletter: http://hulsestrength.com/go/youtube Elliott #39;s Other Channel: http://www.youtube.com/user/elliottsaidwhat Elliott #39;s Facebook...

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Outdoor Kettlebell Workout (while camping with my kids) - Video

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How to Make Other Men Respect You
Sign up Grow Stronger Newsletter: http://hulsestrength.com/go/youtube Elliott #39;s Other Channel: http://www.youtube.com/user/elliottsaidwhat Elliott #39;s Facebook...

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Let #39;s Play Metal Walker (Part 19: Head Trauma for Metal Master Bow)
In this video we finally catch up to Metal Master Kurama but faster than we can quit talking gibberish Metal Master Bow steps in!

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Introduction to Viruses by David Baltimore
Short clip with an introduction to viruses; excerpt of his iBioseminars lecture series. This clip has been uploaded with the intention of using it as part of...

By: Gabriel E. Guzman

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Leukemia Cure Possibly Found in Potentially Major Medical Breakthrough
Memorial Sloan-Kettering researchers genetically alters patients #39; own immune cells to fight a deadly form of leukemia. For more GMA, click here: http://gma.y...

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Mathematics - Biology #39;s New Microscope
Paul Andersen (with the help of PatricJMT) explains why mathematics may be biology #39;s next microscope. Dr. Joel Cohen #39;s Journal article: http://www.plosbiolog...

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Christians Entrepreneurs Cell Group
A group of Christians men praising God.

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The medical and human drama of the T-cell therapy, developed at the University of Pennsylvania, is unfolding in ways the defy the staid traditions of scientific research. On Monday, the New England Journal of Medicine fast-tracked online publication of a paper about Children's first two pediatric patients. But those results - and more - have been out for months, released by the researchers at a conference, or by the families.

The first pediatric patient, Emily Whitehead, 7, of Phillipsburg, Pa., who remains in remission after almost dying, was the subject of worldwide headlines in December.

And last week, the larger story - the harnessing of the immune system to fight cancer after decades of trying - broadened beyond Penn and Children's.

Researchers at Memorial Sloan-Kettering Cancer Center in New York published results from five adult leukemia patients treated with an experimental T-cell therapy much like Penn's. Three of them have been in remission for up to two years; one went into remission but died of a blood clot; and one relapsed and died.

Penn's therapy has worked in adults, too, but those seven patients, who had complete or partial remissions, had a less aggressive form of the disease called chronic myelogenous leukemia.

Sloan-Kettering's results are very impressive, Penn researcher David Porter said.

Penn's team, led by Carl June, will soon collaborate with Sloan-Kettering to see which version of the T-cell therapy works better, Porter said.

The two groups use slightly different viral "vectors" to deliver a therapeutic gene into the T cells. That gene programs the T cells to recognize and kill B cells, the blood component that turns malignant in the leukemias.

"One of the issues is how much does the vector contribute to the patient's response," Porter said. "So we'll trade vectors, then give patients T cells made from both vectors."

Penn is also adapting its T-cell therapy to treat solid tumors such as ovarian cancer. Meanwhile, the early success - although in a small number of patients - is stimulating the field of immunotherapy.

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Parents and Children's Hospital researchers await results on an experimental leukemia gene therapy

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WITHIN just eight days of starting a novel gene therapy, David Aponte's "incurable" leukaemia had vanished. For four other patients, the same happened within eight weeks, although one later died from a blood clot unrelated to the treatment, and another after relapsing.

The cured trio, who were all previously diagnosed with usually fatal relapses of acute lymphoblastic leukaemia, have now been in remission for between 5 months and 2 years. Michel Sadelain of the Memorial Sloan-Kettering Cancer Center in New York, co-leader of the group that designed the trial, says that a second trial of 50 patients is being readied, and the team is looking into using the technique to treat other cancers.

The key to the new therapy is identifying a molecule unique to the surface of cancer cells, then genetically engineering a patient's immune cells to attack it.

In acute lymphoblastic leukaemia, immune cells called B-cells become malignant. The team were able to target a surface molecule known as CD19 that is only present on B-cells. Doctors extracted other immune cells called T-cells from the patients. These were treated with a harmless virus, which installed a new gene redirecting them to attack all cells bearing CD19. When the engineered T-cells were reinfused into the patients, they rapidly killed all B-cells, cancerous or otherwise.

"The stunning finding was that in all five patients, tumours were undetectable after the treatment," says Sadelain.

He reckons that the body should replenish the immune system with regular T-cells and healthy B-cells after a couple of months. However, the patients received donated bone marrow to ensure they could regrow a healthy immune system (Science Translational Medicine, doi.org/kwz).

The treatment is not the first to re-engineer T-cells to attack a form of leukaemia. Last year, an international company called Adaptimmune used the approach to treat 13 people with multiple myeloma it left 10 in remission.

"Although it's early days for these trials, the approach of modifying a patient's T-cells to attack their cancer is looking increasingly like one that will, in time, have a place alongside more traditional treatments," says Paul Moss of Cancer Research UK.

Sadelain's team is now investigating the scope for attacking other cancers. Where no single surface molecule is unique to a cancer, he is seeking to target pairs of molecules that only occur together on cancer cells. In January, he demonstrated this approach by wiping out human prostate tumours implanted in mice, using T-cells engineered to target two surface molecules (Nature Biotechnology, doi.org/kw2).

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Gene therapy cures leukaemia in eight days

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Public release date: 25-Mar-2013 [ | E-mail | Share ]

Contact: Clare LaFond clareh@uw.edu 206-685-1323 University of Washington - Health Sciences/UW News, Community Relations & Marketing

In an animal study, researchers at the University of Washington show that it was possible to use gene therapy to boost heart muscle function. The finding suggests that it might be possible to use this approach to treat patients whose hearts have been weakened by heart attacks and other heart conditions.

Led by University of Washington (UW) Professor and Vice Chair of Bioengineering Michael Regnier and Dr. Chuck Murry, director of the Center for Cardiovascular Biology and co-director of the Institute for Stem Cell and Regenerative Medicine at UW, the study appears online today in the journal Proceedings of the National Academy of Sciences (PNAS).

Normally, muscle contraction is powered by a molecule, the nucleotide called Adenosine-5'-triphosphate (ATP). Other naturally occurring nucleotides can also power muscle contraction, but, in most cases, they have proven to be less effective than ATP.

In an earlier study of isolated muscle, however, Regnier, Murry and colleagues had found that one naturally occurring molecule, called 2 deoxy-ATP (dATP), was actually more effective than ATP in powering muscle contraction, increasing both the speed and force of the contraction, at least over the short-term.

In the new PNAS study, the researchers wanted to see whether this effect could be sustained. To do this, they used genetic engineering to create a strain of mice whose cells produced higher-than-normal levels of an enzyme called Ribonucleotide Reductase, which converts the precursor of ATP, adenosine-5'-diphosphate or ADP, to dADP, which, in turn, is rapidly converted to dATP.

"This fundamental discovery, that dATP can act as a 'super-fuel' for the contractile machinery of the heart, or myofilaments, opens up the possibility to treat a variety of heart failure conditions," Regnier said. "An exciting aspect of this study and our ongoing work is that a relatively small increase in dATP in the heart cells has a big effect on heart performance."

The researchers found that increased production of the enzyme Ribonucleotide Reductase increased the concentration of dATP within heart cells approximately tenfold, and even though this level was still less than one to two percent of the cell's total pool of ATP, the increase led to a sustained improvement in heart muscle function, with the genetically engineered hearts contracting more quickly and with greater force.

"It looks as though we may have stumbled on an important pathway that nature uses to regulate heart contractility," Murry added. "The same pathway that heart cells use to make the building blocks for DNA during embryonic growth makes dATP to supercharge contraction when the adult heart is mechanically stressed."

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Gene therapy may aid failing hearts

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Stem Cell Therapy Cures Paralyzed Vet

By: TheVideOHM

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By Amads Ma. Guerrero Philippine Daily Inquirer

INFORMATION booth

You feel like you have entered an attractive boutique hotel in miniature; everything is neat, clean, almost spotless and sparkling.

This is the Asian Aesthetic Center in Katipunan Avenue, Quezon City (contact number: 7099565) across the Ateneo de Manila. The equipment is state-of-the-art, and there are two main wings: The Dermatology Wing and the Surgical Wing.

In the Dermatology Wing we have a Laser Room, Slimming Room, a Wellness Room and a Facial Treatment Room. The Surgical Room was what interested me mostbut only as a writer and not personally, because my cells are not dysfunctional (to my knowledge!).

Unfortunately, colleague Neilsen and I could not enter the Surgical Wing because a procedure was under way. In this wing, we were told, is a stem cell laboratory unit with the stem cell extractor and activator machines, and a recovery room, along with other amenities.

The clinic is cozy and family-run, you might say. It is headed by Dr. Amy B. Tinaza, a cosmetic surgeon and a stem cell specialist, and her partner (professional as well as personal) Dr. Jomar S. Tinaza, chief facial plastic surgeon and her husband. And the centers PR is a sister in law, Charlotte Tinaza.

The Tinaza couple head the Stem Cell Therapy Team, and there are also Medical, Surgical, Specialist and After-Care Teams.

So why did she (Dr. Amy) choose to be a stem cell specialist? Although stem cell therapy is at an early stage, I believe it is the future of medicine, she replies.

The centers stem cell therapy is the Autologous Fat Stem Cell, in which the stem cell is from the fat cells of the same patient, and transferred back to the patient once the stem cell is activated.

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Stem cell therapy –how profitable?

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ICBR: Cell Therapy
Judi Smith describes what cell therapy is and how it benefits people as well as the three locations where cell therapy is offered by the International Clinic...

By: Ryan Elliott

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Retina Consultants of Southwest Florida

Dr. Ashish Sharma of Retina Consultants of Southwest Florida conducts an eye exam.

The Naples seminar will be from 1 p.m. to 4 p.m. at the Hilton Naples, 5111 U.S. 41 North.

An identical seminar in Fort Myers will be Monday from 9 a.m. to noon at Harborside Convention Center, 1375 Monroe St.

To register to attend, call 1-866-946-6824, or go to http://www.MassEyeAndEar.organization/symposium.

NAPLES Leonard Klein plays tennis and bridge, and both of his games could improve if he has stem cell therapy some day.

The 80-year-old suffers from dry macular degeneration. While his vision loss hasnt worsened in recent months, theres no telling the future.

Studies are under way to see if stem cell therapy can reverse vision loss for people suffering from age-related macular degeneration.

Klein will sign up if such a study opens up to Southwest Florida.

Im a risk taker and always have been, he said recently, before heading to a bridge game in the care center at the Vi at Bentley Village, a continuing care retirement community in North Naples.

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Naples seminar to look at stem cell therapy to aid macular degeneration

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