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Reportlinker Adds Macular Degeneration – Drug Pipeline Analysis and Market Forecasts to 2016

Story Summary: Reportlinker Adds Macular Degeneration – Drug Pipeline Analysis and Market Forecasts to 2016NEW YORK, April 1 Reportlinker. html Macular Degeneration – Drug Pipeline Analysis and Market Forecasts to 2016 Summary GlobalData, the industry analysis specialists new report, Macular Degeneration – Drug Pipeline Analysis and Market Forecasts to 2016 is an essential source of information and analysis on the global macular degeneration market. html Macular Degeneration – Drug Pipeline Analysis and Market Forecasts to 2016 Summary GlobalData, the industry analysis specialists new report, Macular Degeneration – Drug Pipeline Analysis and Market Forecasts to 2016 is an essential source of information and analysis on the global macular degeneration market. The report identifies the key trends shaping and driving the global macular degeneration market. The report identifies the key trends shaping and driving the global macular degeneration market. The report identifies the key trends shaping and driving the global macular degeneration market. The report also provides insight on the prevalent competitive landscape and the emerging players expected to bring significant shift in the market positioning of the existing market leaders. Most importantly, the report provides valuable insight on the pipeline products within the global macular degeneration sector. This report is built using data and information sourced from proprietary databases, primary and secondary research and in house analysis by GlobalDatas team of industry experts. Scope The report analyzes market opportunities and challenges for the global macular degeneration market. Its Scope includes – Annualized global macular degeneration market revenues data from 2001 to 2009, forecast forward for seven years to 2016. – Geographic markets covered in this report include the US, the UK, Italy, Spain, Germany, France, and Japan. – Pipeline analysis data provides a split across different phases, mechanism of actions being developed and emerging trends. – Pipeline analysis data provides a split across different phases, mechanism of actions being developed and emerging trends. Key classes of mechanism of action include as VEGF targetors, angiogenesis inhibitors, photosensitizers, antioxidants, C5 inhibitors, choroidal neovascularization inhibitors, multi-kinase angiogenesis inhibitors, tyrosine kinase inhibitors, FKBP12 binders, mTOR inhibitors, and visual cycle inhibitors. – Analysis of the current and future market competition in the global macular degeneration market. Key market players covered are Alcon Inc. , Miravant Pharmaceuticals, Novartis AG, BioInvent International AB, MacuSight, Inc. , Ophthotech Corporation, Acucela Inc. , Alexion Pharmaceuticals Inc. , Inotek Pharmaceuticals, Inc. , Jerini AG, Neurotech Usa, Inc. , Oxford BioMedica, sanofi-Aventis, Paloma Pharmaceuticals, Inc. , Pfizer Inc. , PhiloGene Inc. , pSivida Corporation, Resolvyx Pharmaceuticals, Inc. , Targa Therapeutics Corp. , and Tracon Pharma Inc. – Insightful review of the key industry drivers, restraints and challenges. Key market players covered are Alcon Inc. , Miravant Pharmaceuticals, Novartis AG, BioInvent International AB, MacuSight, Inc. , Ophthotech Corporation, Acucela Inc. , Alexion Pharmaceuticals Inc. , Inotek Pharmaceuticals, Inc. , Jerini AG, Neurotech Usa, Inc. , Oxford BioMedica, sanofi-Aventis, Paloma Pharmaceuticals, Inc. , Pfizer Inc. , PhiloGene Inc. , pSivida Corporation, Resolvyx Pharmaceuticals, Inc. , Targa Therapeutics Corp. , and Tracon Pharma Inc. – Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications. – Key topics covered include strategic competitor assessment, market characterization, unmet needs and implications for future market associated with macular degeneration. Reasons to buy The report will enhance your decision making capability in a more rapid and time sensitive manner. It will allow you to: – Develop and design your in-licensing and out-licensing strategies through review of pipeline products and technologies and by identifying companies with the most robust pipeline. It will allow you to: – Develop and design your in-licensing and out-licensing strategies through review of pipeline products and technologies and by identifying companies with the most robust pipeline. It will allow you to: – Develop and design your in-licensing and out-licensing strategies through review of pipeline products and technologies and by identifying companies with the most robust pipeline. – Develop business strategies by understanding the trends shaping and driving the global macular degeneration market. – Drive revenues by understanding key trends, innovative products and technologies, market segments and companies likely to impact the global macular degeneration market in future. – Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors. – Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage. – Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships. – Whats the next big thing in the global macular degeneration market landscape? 6 Key Takeaway 10 3 Macular Degeneration Market: Competitive Assessment 11 3. 1 Overview 11 3. 3 Product Profile for the Major Marketed Products in the Macular Degeneration Market 12 3. 3. 1 Lucentis 12 3. 1 Overview 17 4. 2. 1 Technology Trends Analytical Framework 17 4. 5 Macular Degeneration Therapeutic Market – Clinical Pipeline by Mechanism of Action 21 4. 8 Key Takeaway 27 5 Global Macular Degeneration Market: Implications for Future Market Competition 28 6 Macular Degeneration Market: Future Players in the Macular Degeneration Disease Market 30 6. 1 List of Tables Table 1: Macular Degeneration Market, Global, Revenues ($m), 2001-2009 7 Table 2: Macular Degeneration Market, Global, Revenues ($m), 2009-2016 7 Table 3: Major Marketed Products Comparison in Macular Degeneration Market, 2010 15 Table 4: Macular Degeneration Therapeutics – Most Promising Drugs Under Clinical Development, 2010 18 Table 5: Macular Degeneration Therapeutics – NDA Filed, 2010 22 Table 6: Macular Degeneration Therapeutics – Phase III Clinical Pipeline, 2010 22 Table 7: Macular Degeneration Therapeutics – Phase II Clinical Pipeline, 2010 23 Table 8: Macular Degeneration Therapeutics – Phase I Clinical Pipeline, 2010 24 Table 9: Macular Degeneration Therapeutics – Preclinical Pipeline, 2010 25 Table 10: Macular Degeneration Therapeutics – Discovery Pipeline 26 Table 11: List of Discontinued/Suspended Drugs for Macular Degeneration, 2010 26 Table 12: Alcon Inc. – Macular Degeneration Pipeline, 2010 33 Table 13: Novartis AG – Macular Degeneration Pipeline, 2010 35 Table 14: BioInvent International – Macular Degeneration Pipeline, 2010 36 Table 15: MacuSight. – Macular Degeneration Pipeline, 2010 36 Table 16: Ophthotech Corporation – Macular Degeneration Pipeline, 2010 37 Table 17: Pfizer AG – Macular Degeneration Pipeline, 2010 38 Table 18: Acucela Inc. – Macular Degeneration Pipeline, 2010 38 Table 19: Alexion Pharmaceuticals Inc. – Macular Degeneration Pipeline, 2010 39 Table 20: Sanofi-Aventis – Macular Degeneration Pipeline, 2010 40 Table 21: Psivida Corporation – Macular Degeneration Pipeline, 2010 41 1. 2 List of Figures Figure 1: Global Macular Degeneration Market Revenues and Forecast ($m), 2001-2016 7 Figure 2: Opportunity and Unmet Need in the Macular Degeneration Market, 2010 9 Figure 3: Strategic Competitor Assessment of the Major Marketed Products in Macular Degeneration Therapeutics, 2010 12 Figure 4: Technology Trends Analytic Framework – Macular Degeneration Market, 2010 17 Figure 5: Technology Trends Analytic Framework of the Macular Degeneration Pipeline – Description, 2010 18 Figure 6: Macular Degeneration Therapeutics Market – Clinical Pipeline by Mechanism of Action, 2010 21 Figure 7: Macular Degeneration Pipeline by Phase of Clinical Development, 2010 22 Figure 8: Implications for Future Market Competition in Macular Degeneration, 2010 28 Figure 9: Macular Degeneration Therapeutics Market – Clinical Pipeline by Company, 2010 30 Figure 10: Macular Degeneration, Global, Companies That Have the Highest Number of Molecules in the Pipeline, 2010 31 Figure 11: GlobalData Methodology 43 Figure 12: GlobalData Market Forecasting Model 46 Companies mentioned Alcon Inc. Novartis AG BioInvent International MacuSight, Inc. Ophthotech Corporation Pfizer AG Acucela Inc. Alexion Pharmaceuticals Sanofi-Aventis pSivida Corporation To order this report: Pharmaceutical Industry: Macular Degeneration – Drug Pipeline Analysis and Market Forecasts to 2016 More Market Research Report Check our Company Profile, SWOT and Revenue Analysis!…Read the Full Story

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Recommendation and review posted by Bethany Smith

Duplicated DNA unlikely to play role in common disease

Story Summary: This type of genetic variation had been proposed as a possible source of some of the inherited risk of developing these conditions. The research, by a large international team including scientists from the University of Oxford and funded by the Wellcome Trust, is published online today in the journal Nature. For example, there are now around thirty genetic variants known to influence susceptibility to type 2 diabetes, but these only account for about 10 per cent of the known inherited risk of developing this condition. By comparison, this original technique used in the original WTCCC study identified 24 genetic regions. None of the three regions including a CNV is believed to contribute to disease. It seems unlikely that common CNVs play a major role in the genetic basis of common diseases, either through particular CNVs having a strong effect or through a large number of CNVs each contributing a small effect, says Dr Matt Hurles from the Wellcome Trust Sanger Institute. Understanding bipolar disorder and other complex diseases is as much about ruling out possible suspects as it is about identifying new ones, says Nick Craddock, Professor of Psychiatry at Cardiff University and a researcher involved in the study. We now know that we can likely focus our attention away from common CNVs and focus on other common and rare genetic variations, which we hope will provide biological insights that will lead to important advances in human physical and mental health. Researchers involved in the WTCCC will now try to better understand the collective role of both rarer SNPs and rarer CNVs. Researchers involved in the WTCCC will now try to better understand the collective role of both rarer SNPs and rarer CNVs. Researchers involved in the WTCCC will now try to better understand the collective role of both rarer SNPs and rarer CNVs. One such study recently received funding from the Wellcome Trust and the National Institutes of Health in the US….Read the Full Story

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Recommendation and review posted by Bethany Smith

Powerful HIV drugs inhibit retrovirus linked to prostate cancer, chronic fatigue syndrome

Story Summary: These results offer hope to infected persons, but we are still at the early stages of our understanding of the potential link between XMRV and these diseases, said Ila R. Singh, M. D. , Ph. Three other drugs, L-00870812, Zidovudine (ZDV or AZT), and tenofovir disoproxil fumarate (TDF), also effectively prevented virus replication. Singh and Schinazi are currently investigating the development of viral resistance to raltegravir and other active drugs. XMRV, a retrovirus discovered in 2006 by researchers at the University of California, San Francisco, and at the Cleveland Clinic, is one of three retroviruses known to infect people. Other retroviruses that are closely related to XMRV are known to cause leukemia and sarcomas in animals. Last fall, Singh led a study that demonstrated the presence of XMRV in malignant human prostate cancer cells. Last fall, Singh led a study that demonstrated the presence of XMRV in malignant human prostate cancer cells….Read the Full Story

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Recommendation and review posted by Bethany Smith

Tissue engineering, imaging neuronal circuits featured in Cold Spring Harbor Protocols

Story Summary: , April 1, 2010) The goal of tissue engineering is to recapitulate healthy human organs and tissue structures in culture, and then transplant them into patients, where they are fully integrated. edu/star/?PMID=3157) present a protocol for the use of The Mouse Cornea as a Transplantation Site for Live Imaging of Engineered Tissue Constructs. This is a modified version of the classical corneal micropocket angiogenesis assay, which employs it as a live imaging window to monitor angiogenic hydrogel tissue constructs. Neurons are organized into anatomical and functional groups called circuits. The activity of these circuits is traditionally monitored using conventional electrophysiological techniques. But some cells, such as the submandibular ganglia, are difficult to impale for intracellular recordings. Instead, viral vectors can be used to deliver fluorescent calcium sensors for detecting activity in a living animal. edu/labs/enquist/), provides detailed instructions for the use of the pseudorabies virus (PRV) as a vector for imaging connectivity and activity of neuronal circuits. PRV has a broad host range but does not infect higher-order primates, and it travels along chains of synaptically connected neurons. The PRV strain used in this procedure encodes G-CaMP2, a sensitive fluorescent calcium sensor protein. dtl), the method allows for reliable detection of endogenous circuit activity at single-cell resolution. Life science researchers can access the entire collection via institutional site licenses, and can add their suggestions and comments to further refine the techniques. About Cold Spring Harbor Laboratory Press:Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media, located on Long Island, New York. Since 1933, it has furthered the advance and spread of scientific knowledge in all areas of genetics and molecular biology, including cancer biology, plant science, bioinformatics, and neurobiology. It is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public….Read the Full Story

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Recommendation and review posted by Bethany Smith

OHSU research explains repeated infection by some viruses

Story Summary: The research involves cytomegalovirus (CMV), which infects 50 percent to 80 percent of the U. S. population before age 40. Details of the new findings are printed in this weeks online edition of the journal Science. When most viruses infect a host, the immune system remembers the disease and protects against re-infection. CMV evades these alert systems by making genes that disrupt the MHC-I molecules ability to communicate an ongoing infection to the T cells. In essence, CMV is able to cutoff an infected cells call for elimination. D. , a senior scientist at the VGTI and a professor of molecular microbiology and immunology in the OHSU School of Medicine. The results of this study primarily illustrate the significant barriers to creating a vaccine that will prevent CMV infection. Because of their ability to overcome vector-directed immunity, CMV viral vectors may be used repeatedly to stimulate an immune response against a variety of pathogens, including other viruses such as HIV and hepatitis C, but also malaria parasites and tuberculosis bacteria. This research may therefore help aid in the development of such vaccines….Read the Full Story

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Researchers discover weak link in Alzheimers drug candidates

Story Summary: Researchers discover weak link in Alzheimers drug candidatesSome current therapies being investigated for Alzheimers disease may cause further neural degeneration and cell death, according to a breakthrough discovery by UC San Diego researchers. The researchers found that the nonamyloidgenic peptides formed active ion channels that caused the cells to take in very high levels of calcium ions, which damaged synaptic efficiency and eventually killed neurons, neurons that are linked to memory loss in human brain. Through our research we have provided a structure and mechanism (an ion channel) that can account for the pathology. Lal said the use of advanced nanotechnology and biology combined with a multi disciplinary approach, aided in the researchers breakthrough discovery….Read the Full Story

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Recommendation and review posted by Bethany Smith

NYSCF fellow lead author on study that derives floor plate tissue from embryonic stem cells

Story Summary: Floor plate development is essential in the development of the brain. For the first time we are able to create this unique population of cells that exists in the very early developing human brain, says Dr. Fasano. Understanding how the brain develops will be key in understanding how brain diseases occur such as Parkinsons disease. NYSCF is very proud to fund the work of young scientists that contributes so significantly to future healthcare. It is a privilege to have Dr. Fasano in our fellowship program. Embryonic stem cells are still the gold standard for monitoring pluripotency and differentiation capabilities. Chris is one of the premier young scientists in the field of stem cell research and we are excited to have him in our fellowship program. About The New York Stem Cell FoundationFounded in 2005, The New York Stem Cell Foundation (NYSCF) is dedicated to accelerating cures for the major diseases of our time through stem cell research….Read the Full Story

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Recommendation and review posted by Bethany Smith

MSU scientists find bacterium can halt dengue virus transmission

Story Summary: New research by Michigan State University entomologists has found that a bacterium can stop dengue viruses from replicating in the mosquitoes. The Wolbachia bacterium cant be passed from mosquitoes to humans. The strain the Australian researchers used causes the mosquitoes to die a bit sooner. The strain the Australian researchers used causes the mosquitoes to die a bit sooner. There are advantages to both. The longer the mosquitoes live, the more likely they are to pass on the Wolbachia infection to their offspring and infect the entire population in a shorter timeframe. The longer the mosquitoes live, the more likely they are to pass on the Wolbachia infection to their offspring and infect the entire population in a shorter timeframe. But if the mosquitoes die earlier, they cant bite people and transmit the dengue virus. But if the mosquitoes die earlier, they cant bite people and transmit the dengue virus. In both instances, the results demonstrate the potential using the Wolbachia bacterium as a control method for dengue virus. In both instances, the results demonstrate the potential using the Wolbachia bacterium as a control method for dengue virus. Only when we know the mechanisms underlying Wolbachia-mediated viral interference, will we will be able to why its happening and further improve the efficiency of the viral interference, he said. Only when we know the mechanisms underlying Wolbachia-mediated viral interference, will we will be able to why its happening and further improve the efficiency of the viral interference, he said. While dengue fever is rare in the continental United States, Hawaii was the site of a dengue epidemic in 2001….Read the Full Story

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Recommendation and review posted by Bethany Smith

If suppressed for 12 months, low risk of viral rebound above 1,000 copies

Story Summary: However, they found that during the first year of HIV treatment, viral load was above the threshold of 1,000 copies/ml associated with onward transmission for approximately 5% of the time. In this nationwide population-based cohort study of Danish HIV-infected patients on HAART highly active antiretroviral therapy with more than six months of suppressed viral load, we found that the risk of experiencing a viral load above 1000 copies/ml and thereby transmitting HIV sexually was very low, comment the investigators. Danish HIV physicians wished to assess the likelihood of viral load increasing to levels associated with onward transmission in patients taking suppressive HIV treatment. The risk of transmission was especially high during the first six months of HIV therapy, when 8% of the time was spent with a viral load above 1000 copies/ml. During the next six months, viral load was at potentially infectious levels for a little over 1% of the time. Thereafter, viral load was above the potentially infectious threshold for an average of 0. 03% of follow-up was spent with a viral load above 1000 copies. This was attributed to poorer treatment adherence in this population. Assuming that there is a viral threshold of infectiousness, our results indicate that the risk of viraemia is very low in patients on successful antiretroviral treatment, write the investigators. Noting that HIV-infected patients have, however, an increased risk of abrupt viraemia in not just the first six months but the first twelve months of episodes with undetectable viral load, the investigators recommend there would be a substantial gain in reducing the risk of infecting the sexual partner, if the time limit recommended by the Swiss was extended from six months to at least twelve months. Noting that HIV-infected patients have, however, an increased risk of abrupt viraemia in not just the first six months but the first twelve months of episodes with undetectable viral load, the investigators recommend there would be a substantial gain in reducing the risk of infecting the sexual partner, if the time limit recommended by the Swiss was extended from six months to at least twelve months. ReferenceEngsig FN et al. Risk of high-level viraemia in HIV-infected patients on successful antiretroviral treatment for more than 6 months. ReferenceEngsig FN et al. Risk of high-level viraemia in HIV-infected patients on successful antiretroviral treatment for more than 6 months. 2009….Read the Full Story

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Recommendation and review posted by Bethany Smith

Human Gene Patents Invalidated

Basing his decision on legal arguments that human genes are products of nature and hence cannot be patented, in March of 2010 a U.S. District Court judge invalidated several patents held by a company called Myriad Genetics on the human breast cancer genes, BRCA1 and BRCA2. Myriad Genetics sells a kit used to test for the two genes for about $3,000. The company tried to argue that their method of isolating the genes changed the genes, and thus made them patentable. But the judge ruled that such an argument was just a trick to circumvent the prohibition on the direct patenting of DNA.

About 20% of human genes have already been patented. A number of biotech companies were planning to make a hefty profit by developing and selling patent-protected genetic tests or by selling the patent rights to others. Whether all of those patents could ultimately be invalidated is unclear. With potentially billions of dollars at stake, the decision is likely to be appealed.

Medical and research organizations and patients are pleased by the decision. If it holds up on appeal it should provide wider access to human genes currently under patent protection, and ultimately make genetic tests like those for BRCA1 and BRCA2 less expensive.

Recommendation and review posted by Bethany Smith

In Southeast Community Hospitals Clostridium Difficile Is More Common Than MRSA

Story Summary: Previous studies were based on estimates using hospital ICD-9-CM discharge diagnosis codes. To better understand and identify infection trends, researchers also examined 949 other cases of HAIs. They found bloodstream infections occurred in 481 patients on general hospital wards and device-related infections occurred in 468 patients in intensive care units (ICU). Source: Sharon Reis Society for Healthcare Epidemiology of America Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. Contact Our News EditorsFor any corrections of factual information, or to contact the editors please use our feedback form. Where to Go When You Cant Get a Good Nights SleepWhen you cant get a good nights sleep on a regular basis, a sleep center can help you figure out whats keeping you up. At a sleep center, doctors measure different body functions while you sleep to figure out if you have a sleep disorder….Read the Full Story

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Recommendation and review posted by Bethany Smith

Clues To Language Learning Offered By Songbirds Genome

Story Summary: Researchers who collaborated on the finch genome found a much higher proportion of the birds DNA is actively engaged by the act of singing songs. The system for singing has much more complexity than we imagined, said co-author Erich Jarvis, Ph. We were also able for the first time to use the genome sequence to infer the regulatory regions that turn genes on and off and the manner in which they may interact, he said. Jarvis noted that sequencing additional genomes, like the parrot genome his lab is working on with the Warren laboratory, would contribute valuable information about spoken language. The zebra finch is only the second bird to have its genome decoded. More than 20 institutions worldwide collaborated on the zebra finch genome project. The organizing committee of the zebra finch genome sequencing project included Wes Warren of Washington University School of Medicine; David Clayton of the University of Illinois at Urbana-Champaign, Hans Ellegren of Uppsala University in Sweden; and Arthur P. Arnold of the University of California-Los Angeles. Source: Mary Jane Gore Duke University Medical Center Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. Please send any medical news or health news press releases to: These are the most read articles from this news category for the last 6 months: Do Genes Play A Role In PTSD? Please send any medical news or health news press releases to: These are the most read articles from this news category for the last 6 months: Do Genes Play A Role In PTSD? The Heimlich Maneuver – First Aid for ChokingYou may recognize the universal sign for choking, but its also important to know what to do to help someone who is making that sign. The Heimlich Maneuver – First Aid for ChokingYou may recognize the universal sign for choking, but its also important to know what to do to help someone who is making that sign. Learning the right way to perform the Heimlich maneuver means you could be ready to save someones life. Learning the right way to perform the Heimlich maneuver means you could be ready to save someones life….Read the Full Story

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Recommendation and review posted by Bethany Smith

Aging gene found to govern lifespan, immunity and resilience

Story Summary: To do that, we looked at a gene that we already knew to be involved in the ageing process, called DAF-16, to see how it may determine the different rates of ageing in different species. And, importantly, the differences in DAF-16 corresponded to differences in longevity, stress resistance and immunity between the four species – in general higher levels of DAF-16 activity correlated with longer life, increased stress resistance and better immunity against some infections. Dr May continued: DAF-16 is part of a group of genes that drive the biological processes involved in ageing, immunity and responses to physical or environmental stresses. Improving the healthspan to mirror increases in the lifespan is an important subject of BBSRC research. — full story– 27 July 2009Researchers have developed a new technique that allows them to make a movie of bacteria infecting their living host. — full story– 23 July 2009A small green beetle may have some interesting lessons to teach scientists about optics and liquid crystals – complex mechanisms the insect uses to create a shell so strikingly beautiful. — full story– 9 July 2009Although the fact that we generate new brain cells throughout life is no longer disputed, their purpose has been the topic of much debate….Read the Full Story

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Recommendation and review posted by Bethany Smith

Electronic medical records may accelerate genome-driven diagnoses and treatments

Story Summary: Electronic Medical Records May Accelerate Genome-Driven Diagnoses and Treatments A new study reveals an exciting potential benefit of the rapidly accumulating databases of health care information, the ability to make unprecedented links between genomic data and clinical medicine. The research, published by Cell Press in the April issue of the American Journal of Human Genetics,supports the idea that large scale DNA databanks linked to electronic medical record (EMR) systems provide a valuable platform for discovering, assessing and validating associations between genes and diseases. The deployment of EMRs offers the hope of improving routine care, not only by enhancing individual practitioner access to patient information but also by aggregating information for clinical research, explains senior study author Dr. Dan M. Roden from Vanderbilt University School of Medicine in Nashville Tennessee. It took only four months to generate a set of nearly 10,000 records from which the cases and controls were identified. Our data demonstrate that phenotypes representing clinical diagnoses can be extracted from EMR systems, and support the use of DNA resources coupled to EMR systems as tools for rapid generation of large datasets required for replication of associations found in research and for discovery in genome science, concludes Dr. Roden. The researchers include Marylyn D. Ritchie, Joshua C. Denny, Dana C. Crawford, Andrea H. Ramirez, Justin B. Weiner, Jill M. Pulley, Melissa A. Basford, Kristin Brown-Gentry, Jeffrey R. Balser, Daniel R. Masys, Jonathan L. Haines, Dan M. Roden, of Vanderbilt University School of Medicine, Nashville, TN. Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record. Or view hourly updated newsfeeds in your RSS reader:FeedbackTell us what you think of the new ScienceDaily — we welcome both positive and negative comments….Read the Full Story

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Recommendation and review posted by Bethany Smith

JCI online early table of contents: April 1, 2010

Story Summary: Recent data have indicated that this approach, which is known as oncolytic virotherapy, has potential. Now, Richard Vile and colleagues, at the Mayo Clinic, Rochester, have found that this approach can be combined with a standard clinical therapy to provide substantial regression and cure of tumors in mice, leading them to suggest that this combinatorial approach could be of tremendous benefit in the clinic. TITLE: Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in miceEDITORS PICK: Genetic form of anemia defined molecularlySideroblastic anemia is a form of anemia caused by an inability to incorporate iron into hemoglobin, something that is essential if the molecule is to perform its vital function of carrying oxygen from the lungs to the tissues. Specifically, they find that in human cells, GLRX5 is essential for generating iron-sulfur clusters (molecular groups that facilitate a wide range of cellular activities, including sensing of iron and oxygen) and maintaining normal levels of iron in cellular compartments known as mitochondria and the cytosol. Further analysis revealed a molecular explanation for why GLRX5 protein deficiency caused disease in only one cell type in the body, the red blood cell. TITLE: Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblastsAUTHOR CONTACT: Tracey A. Rouault National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA. gov. CARDIOLOGY: Protecting heart muscle cells from deathA team of researchers, led by Uta Hoppe, at the University of Cologne, Germany, has identified a role for the protein connexin 43 in protecting mouse heart muscle cells from death. The team therefore suggest that it might be an attractive target for therapies that help protect cells from injuries that normally result in death, such as the injuries suffered by cells as a result of heart attack. Several lines of evidence indicate that the PKC protein and mitoKATP potassium channels in the inner mitochondrial membrane have a central role in protecting cells from death. Lloyd Miller and colleagues, at the University of California at Los Angeles, have now provided new insight into this by studying a mouse model of the condition. Specifically, they found that the immune molecule IL-17 has an important role in controlling Staphylococcus aureusinfection in the mouse skin. TITLE: IL-17 is essential for host defense against cutaneous Staphylococcus aureusinfection in miceAUTHOR CONTACT: Lloyd S. Miller University of California at Los Angeles, Los Angeles, California, USA. In this regard, Behazine Combadiere and colleagues, at INSERM U945, France, have now determined that immune cells known as CD4+ T cells have an important role in controlling skin lesion size at sites of revaccination. Specifically, high numbers of these cells correlated with small skin lesion size upon revaccination. New insight into the signaling pathways that contribute to visceral white fat tissue dysregulation has now been provided by Philippe Lefebvre and colleagues, at INSERM, UMR1011, France, who determined that the PPAR-gamma signaling pathway operates differently in the visceral white fat tissue of lean and obese mice and humans. Specifically, it shows increased sensitivity to activation by the anti-diabetic drug rosiglitazone in obese mice and humans. There are at least ten types of enteroendocrine cell and it has been hard to determine the exact role of each cell type and hormone they secrete because many of the hormones have partially overlapping functions. Surviving mice were smaller than normal littermates, had soft stool, and were impaired in their ability to absorb fat in the intestines. TITLE: Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survivalAUTHOR CONTACT: Georg Mellitzer Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, Universite de Strasbourg, Illkirch, France. Gerard Gradwohl Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, Universite de Strasbourg, Illkirch, France. These vessels have a role in many processes in the body, including regulating fluid levels in tissues and immune surveillance. Although dysfunction in the lymphatic system contributes to human diseases such as the spread of cancer to other sites and lymphademas (localized fluid retention and tissue swelling), little is known about the molecules that regulate the formation of new lymphatic vessels, a process known as lymphangiogenesis. However, a team of researchers, led by Sophia Tsai and Ming-Jer Tsai, at Baylor College of Medicine, Houston, has now identified a role for the gene regulatory protein COUP-TFII in lymphangiogenesis in mouse embryonic development and tumor lymphangiogenesis in adult mice. The authors therefore suggest that COUP-TFII might be an effective molecular target in pro-lymphangiogenic treatment of lymphedemas or in antilymphangiogenic therapy targeting tumor spreading via the lymphatic vessels. TITLE: Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel developmentCARDIOLOGY: Switching energy source in stressed hearts under the control of the protein MycWhen heart muscle cells are put under stress, for example by high blood pressure or by oxygen deprivation (such as occurs during a heart attack), they switch from using fatty acids as their source of energy to using glucose. Initial analysis by the authors indicated that expression of Myc was increased in the hearts of mice under conditions that model high blood pressure as well as conditions that model the oxygen deprivation associated with a heart attack. Furthermore, increasing Myc expression in the heart in the absence of any stress condition made the heart muscle cells switch from fatty acids to glucose as their source of energy. Importantly, the Myc-mediated switch to using glucose as an energy source was associated with preserving heart function and improving recovery from oxygen deprivation. TITLE: Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in miceAUTHOR CONTACT: W. Robb MacLellan David Geffen School of Medicine at UCLA, Los Angeles, California, USA….Read the Full Story

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  3. JCI online early table of contents: Feb. 8, 2010


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Anti-HIV drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome

Story Summary: The results were published on April 1, 2010 by the journal PLoS One. The findings suggest that if XMRV (xenotropic murine leukemia virus-related virus) is proven to be a cause for prostate cancer or chronic fatigue syndrome, those illnesses may be treatable with drugs already approved for treating HIV. We will need to see the results of clinical trials before these drugs can be used in a clinical setting. Our study showed that these drugs inhibited XMRV at lower concentrations when two of them were used together, suggesting that highly potent cocktail therapies might inhibit the virus from replicating and spreading, Schinazi says. This combination of therapies might also have the added benefit of delaying or even preventing the virus from mutating into forms that are drug-resistant. Although both XMRV and HIV are retroviruses, there is little similarity between HIV and XMRV at the protein level. Singh and Schinazi are now investigating the development of resistance in XMRV to raltegravir and other drugs. Singh led a recently published study that demonstrated the presence of XMRV in 27 percent of prostate cancers examined, with the virus more likely to be found in the most-aggressive tumors….Read the Full Story

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Turmeric and Amla Health Remedies

Be Your Own Doctor

There various vegetables , fruits and nuts readily available in our kitchens and our local markets. But we often forget the medicinal value and no soon we have a ailment we run to the doctors for help. It is very important to consult a doctor and take the medication, but the herbal medicenes that are available readily at our kitchen could help us if the ailment is very nominal. For eg. if someone has a gastric problem, or an acidity problem , then there are so many condiments, and other herbal cures which are at our reach, but that goes unnoticed or being ignored. I give you a few remedies on very normal and common ailments from the vegetables, condiments, fruits etc available at home.

1. Amla (indian gooseberry) Genera-Phylanthus Speices-emblica Read more…

Kama Raja Old Formula for Penis Enhancement!

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New tool for RNA silencing

Story Summary: New tool for RNA silencingApril 1, 2010 Anti-sense reagents have been developed for C. Elegansmicro RNA. Researchers writing in BioMed Centrals open access journal Silencehave created the first class of reagents to potently and selectively inhibit miRNAs in this widely used model organism. Wen-hong Li, from the University of Texas Southwestern Medical Center, USA, worked with a team of researchers including Dr. Genhua Zheng and Dr. Victor Ambros (University of Massachusetts Medical School) to develop this latest addition to the genetics toolkit. He said, Caenorhabditis elegans has long been used as a model organismfor studying the regulation and function of small non-coding RNA molecules, and yet no antisense reagents have been available to reliably inhibit miRNAs in worms. They can be used combinatorially to inhibit more than one miRNA in the same animal. They conclude, Combined with numerous mutants or reporter stains available, these reagents should provide a convenient approach to examine genetic interactions that involve miRNA, and may facilitate studying functions of miRNAs, especially ones whose deletion strains are difficult to generate. More information:Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent, Genhua Zheng, Victor Ambros and Wen-hong Li, Silence2010, 1:9. jpg If your skin is cut deeply, meaning a cut to dermis why is that we can see scar tissue. html I didnt even realize that human cloning was yet scientifically possible. I know that some scientists cloned a sheep many years ago. Structure of Evolutionary Theory, why did he leave this out?Mar 29, 2010 Hi, Ive been leafing through the index of Stephen Jay Goulds book The Structure of Evolutionary Theory on the amazon index feature and he has only mentioned Edward O. Wilson on two pages in the. This has been shown by a new study carried out by researchers at Uppsala University and Stockholm University. This has been shown by a new study carried out by researchers at Uppsala University and Stockholm University. The . . . When cells are deprived of water, they shrink, collapsing in upon themselves and, without water as a medium, chemicals and enzymes inside the cells may malfunction. com) — A genome is a complex system of genes and factors that regulate them….Read the Full Story

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Gene flaw found in induced stem cells

Story Summary: Stem-cell researchers have puzzled over why reprogrammed cells taken from adult tissues are often slower to divide and much less robust than their embryo-derived counterparts. However, because scientists have always obtained iPS and ES cells from different sources — in general, iPS cells are derived from skin samples taken during biopsies and ES cells from excess embryos from fertility clinics — it was impossible to tell whether the discrepancies could be chalked up to the unique biology of the cells or the genetics of the underlying tissue. The team added the stem cells into embryos from mice of a different colour; once each mouse matures, the colouring of its coat reveals how much the stem cells contributed to forming its tissue. When the scientists compared genome-wide expression patterns between the two cell types, they discovered that a small stretch of DNA on the long arm of chromosome 12 displayed significantly different gene activity. In this region, two genes and a slew of tiny regulatory sequences called microRNAs were consistently activated in the ES cells and silenced in the iPS cells, regardless of whether the reprogrammed cells came originally from skin, brain, blood or other tissue. Although the function of the key genes is unknown, this region is usually silenced in mouse sperm cells and activated in other types of cell, so reprogramming might somehow mimic the silencing process, the authors speculate. This is an important step towards identifying the differences that may exist in those imperfectly reprogrammed cells, says Sheng Ding, a stem-cell researcher at the Scripps Research Institute in La Jolla, California. It points towards the possibility that hot spots for epigenetic abnormalities exist also in human iPS cells, he says. It points towards the possibility that hot spots for epigenetic abnormalities exist also in human iPS cells, he says. A profound abnormality like that could confound results obtained with patient-specific iPS cells. Stadtfeld agrees, noting that the silenced genes might not matter for tissues in which such genes have no role. Although findings in mice dont always apply to humans, if a similar gene signature is found in human cells, it could help researchers to identify which iPS cells to avoid using, and which stand the best chance of producing the desired tissue. #9970Day is not far away when we will make iPS cells behaving like ES cells. co. in, +919452196686(M)Add your own commentThis is a public forum. You need to be registered with Nature to leave a comment….Read the Full Story

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  3. Scientists Reveal How Induced Pluripotent Stem Cells Differ From Embryonic Stem Cells and Tissue of Derivation-11/4/09


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Human genome at ten: Life is complicated

Story Summary: Erika Check Hayden asks if theres a way to make life simpler. The true number, it turns out, is closer to 21,000, and biologists now know what many of those genes are. Few predicted, for example, that sequencing the genome would undermine the primacy of genes by unveiling whole new classes of elements — sequences that make RNA or have a regulatory role without coding for proteins. Non-coding DNA is crucial to biology, yet knowing that it is there hasnt made it any easier to understand what it does. We fooled ourselves into thinking the genome was going to be a transparent blueprint, but its not, says Mel Greaves, a cell biologist at the Institute of Cancer Research in Sutton, UK. Instead, as sequencing and other new technologies spew forth data, the complexity of biology has seemed to grow by orders of magnitude. Delving into it has been like zooming into a Mandelbrot set — a space that is determined by a simple equation, but that reveals ever more intricate patterns as one peers closer at its boundary. How tantalizing this notion is depends somewhat on the scientist; some say it is enough to understand the basic principles that govern life, whereas others are compelled to reach for an answer to the next question, unfazed by the ever increasing intricacies. For the rest of the twentieth century, scientists expanded on the details of the model, but they were confident that they understood the basics. Just one decade of post-genome biology has exploded that view. Researchers from an international collaborative project called the Encyclopedia of DNA Elements (ENCODE) showed that in a selected portion of the genome containing just a few per cent of protein-coding sequence, between 74% and 93% of DNA was transcribed into RNA2. Much non-coding DNA has a regulatory role; small RNAs of different varieties seem to control gene expression at the level of both DNA and RNA transcripts in ways that are still only beginning to become clear. The protein p53, for example, was first discovered in 1979, and despite initially being misjudged as a cancer promoter, it soon gained notoriety as a tumour suppressor — a guardian of the genome that stifles cancer growth by condemning genetically damaged cells to death. It also binds to numerous other proteins, which can modify its activity, and these protein-protein interactions can be tuned by the addition of chemical modifiers, such as phosphates and methyl groups. The data deluge following the Human Genome Project is undoubtedly part of the problem. Gone are the days when cloning and characterizing a gene would garner a paper in a high-impact journal. Now teams would have to sequence an entire human genome, or several, and compare them. In many cases youve got high-throughput projects going on, but much of the biology is still occurring on a small scale, says James Collins, a bioengineer at Boston University in Massachusetts. A new discipline — systems biology — was supposed to help scientists make sense of the complexity. So far, all these attempts have run up against the same roadblock: there is no way to gather all the relevant data about each interaction included in the model. In retrospect, it was probably unrealistic to expect that charting out the biological interactions at a systems level would reveal systems-level properties, when many of the mechanisms and principles governing inter-and intracellular behaviour are still a mystery, says Leonid Kruglyak, a geneticist at Princeton University in New Jersey. You would have all this stuff in your detector, and you would have no idea how to think about it, because it would involve processes that you didnt understand at all, says Kruglyak. This doesnt mean that biologists are stuck peering ever deeper into a Mandelbrot set without any way of making sense of it. Biology is entering a period where the science can be underlaid by explanatory and predictive principles, rather than little bits of causality swimming in a sea of phenomenology, says Eric Davidson, a developmental biologist at the California Institute of Technology in Pasadena. Theyre still using a systems approach, but focusing it through a more traditional, bottom-up lens. His group has spent almost a decade dissecting sea-urchin development by systematically knocking out the expression of each of the transcription factors — regulatory proteins that control the expression of genes — in the cells that develop into skeleton. Yet it includes all of these regulatory interactions and then attempts to draw from them common guiding principles that can be applied to other developing organisms. For example, transcription factors encoded in the urchin embryos genome are first activated by maternal proteins. Like the sea urchin, other organisms from fruitflies to humans organize development into modules of genes, the interactions of which are largely isolated from one another, allowing evolution to tweak each module without compromising the integrity of the whole process. The fundamental idea that the genomic regulatory system underlies all the events of development of the body plan, and that changes in it probably underlie the evolution of body plans, is a basic principle of biology that we didnt have before, says Davidson. Davidson calls his work a proof of principle that you can understand everything about the system that you want to understand if you get hold of its moving parts. He credits the Human Genome Project with pushing individual biologists more in the direction of understanding systems, rather than staying stuck in the details, focused on a single gene, protein or other player in those systems. The eye of the beholderSo how is it that Davidson sees simplicity and order emerging where many other biologists see increasing disarray? Researchers who work on model systems, for instance, can manipulate those systems in ways that are off-limits to those who study human biology, arriving at more definitive answers. He used to make the tongue-in-cheek prediction that the budding yeast would be solved by 2007 when every gene and every interaction has been characterized. He has since written more seriously that this feat will be accomplished within the next few decades5. Johnston argues that it is neither possible not necessary to arrive at the quantitative understanding that he hopes to achieve for the glucose-sensing pathway for every other system in yeast. You have to decide what level of understanding youre satisfied with, and some people respond that theyre not satisfied at any level — that we have to keep going, he says. It plays out every day as study sections and peer reviewers decide which approach to science is worth funding and publishing. The edge of the universeSome, such as Hiroaki Kitano, a systems biologist at the Systems Biology Institute in Tokyo, point out that systems seem to grow more complex only because we continue to learn about them. Bert Vogelstein, a cancer-genomics researcher at Johns Hopkins University in Baltimore, Maryland, has watched first-hand as complexity dashed one of the biggest hopes of the genome era: that knowing the sequence of healthy and diseased genomes would allow researchers to find the genetic glitches that cause disease, paving the way for new treatments. Indeed, drugs that influence those bafflingly complex signal-transduction pathways are among the most promising classes of new medicines being used to treat cancer. The complexity explosion, therefore, does not spell an end to progress. Mina Bissell, a cancer researcher at the Lawrence Berkeley National Laboratory in California, says that during the Human Genome Project, she was driven to despair by predictions that all the mysteries would be solved. Biology is complex, and that is part of its beauty. Add your own commentThis is a public forum. You can be controversial, but please dont get personal or offensive and do keep it brief. Remember our threads are for feedback and discussion – not for publishing papers, press releases or advertisements. Remember our threads are for feedback and discussion – not for publishing papers, press releases or advertisements. You need to be registered with Nature to leave a comment. Please log in or register as a new user….Read the Full Story

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Recommendation and review posted by Bethany Smith

Lights, camera, action for cells

Story Summary: They perturbed gene expression using short interfering RNA molecules (siRNA) and then observed the effects over two days on fluorescently labelled chromosomes using time-lapse imaging. The method recognized with 87% accuracy changes in the nuclear shape that were related to basic functions such as cell division, proliferation, survival and migration. Technically this paper is really a tour de force, says Jason Swedlow, a cell biologist at the University of Dundee, UK. The systematic way the group has gone through and knocked down genes and filmed the results is really impressive. Even though we know the sequences of different genomes, we dont yet know the names of all the genes involved in a fundamental process like cell division. The systematic way the group has gone through and knocked down genes and filmed the results is really impressive. Nearly half of these genes are involved in mitosis (see videoshowing normal cell division). This showed that delays in mitosis result in cell death and abnormal chromosome segregation, the process by which paired chromosomes split (see videoof cell division disrupted using siRNA). Some genes were associated with problems in early cell division, and others were linked to problems in a later stage called cytokinesis, in which cells containing two nuclei divide in half. Its a very comprehensive study, says Michael Boutros, a cell biologist at the German Cancer Research Center, also in Heidelberg. It broadly reflects the different effects that genes have on the cell cycle. Thats going to be a very important contribution. Thats going to be a very important contribution. Thats going to be a very important contribution. Cellular YouTubeThe next step is for multiple research groups to validate the hundreds of candidate mitotic genes found in this screen and to figure out how they guide cell division, Ellenberg says. Cellular YouTubeThe next step is for multiple research groups to validate the hundreds of candidate mitotic genes found in this screen and to figure out how they guide cell division, Ellenberg says. Cellular YouTubeThe next step is for multiple research groups to validate the hundreds of candidate mitotic genes found in this screen and to figure out how they guide cell division, Ellenberg says. Cellular YouTubeThe next step is for multiple research groups to validate the hundreds of candidate mitotic genes found in this screen and to figure out how they guide cell division, Ellenberg says. In the long run, the technology will really allow us to diagnose and treat cancer much better, he says. In the long run, the technology will really allow us to diagnose and treat cancer much better, he says. Overwhelmingly the reaction is very positive, Ellenberg says. Overwhelmingly the reaction is very positive, Ellenberg says. People bombard me with e-mails and ask, Can I have the movies for my favourite gene? People bombard me with e-mails and ask, Can I have the movies for my favourite gene? People bombard me with e-mails and ask, Can I have the movies for my favourite gene? Now they can log on to the database and discover clusters of genes that underlie a particular response in cells, he says. Now they can log on to the database and discover clusters of genes that underlie a particular response in cells, he says. They dont want to do the silencing experiments themselves anymore. They dont want to do the silencing experiments themselves anymore. People can go to the data set and discover new relationships that have not been described in the paper. To have everything available online is a big step forward. There are currently no comments. Add your own commentThis is a public forum. Remember our threads are for feedback and discussion – not for publishing papers, press releases or advertisements. You need to be registered with Nature to leave a comment….Read the Full Story

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Future funding for agricultural research uncertain

Story Summary: The lions share of that funding comes from financial donors that include government agencies in the United States and United Kingdom, and the Bill & Melinda Gates Foundation. Agricultural strategyUnder the proposed reforms, donor contributions would go into a common pot, which would then be distributed among eight broad research areas, or mega programmes. ) The idea is to cut out research overlap between centres, create a clear mission and refocus research on the questions and problems donors want tackled. Donors say that they want this reform process accelerated, and to see more flesh on the bones of the outlined research proposals. In particular, they want to see three fast-tracked research programmes launched by the end of the year, including one on the impact of climate change on agriculture, says Jonathan Wadsworth, senior agricultural research adviser to Britains Department for International Development (DFID). DFID is one of the centres largest donors, and has said that it wants to double funding to the group in future. But Wadsworth told that funding hikes will depend on the reforms, and on the centres achieving their research targets. The Bill & Melinda Gates Foundation, the worlds largest private foundation, contributes around $80 million per year to the CGIARs budget and has committed funding to the centres until 2013. Changes to be madeThere is some truth in Pingalis criticisms, says Colin Chartres, director general of the International Water Management Institute in Colombo, Sri Lanka, one of the CGIARs centres. But he says that he and others developing the reforms have deliberately not presented specific ideas so that the conference participants, including farmers, can have input into the strategy. In particular, the CGIAR would focus research on specific regions, and target the more vulnerable groups of people for its programmes. A meeting on 24 May will decide which of the broad programmes will be the first to be put to donors for funding decisions, Perez del Castillo added. You can be controversial, but please dont get personal or offensive and do keep it brief. You need to be registered with Nature to leave a comment….Read the Full Story

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New Mouse Models Give Insight to Gene Mutation That Is Potential Cause Of Parkinsons Disease

Story Summary: Newswise — Using new one-of-a-kind mouse models that promise to have a significant impact on future Parkinsons disease research, Mount Sinai School of Medicine researchers are among the first to discover how mutations in a gene called LRRK2 may cause inherited (or familial) Parkinsons disease, the most common form of the disease. Even though it was clear that LRRK2 played a role in causing Parkinsons, scientists had not been able to fully pursue the discovery of the gene mutation due to lack of a suitable animal model with abnormal forms of the gene. They are now pursuing the question whether the increased kinase activity accounts for the reduced dopamine levels, subsequently leading to neurodegeneration. About The Mount Sinai Medical CenterThe Mount Sinai Medical Center encompasses The Mount Sinai Hospital and Mount Sinai School of Medicine. The Mount Sinai Hospital is one of the nations oldest, largest and most-respected voluntary hospitals. Founded in 1852, Mount Sinai today is a 1,171-bed tertiary-care teaching facility that is internationally acclaimed for excellence in clinical care. Last year, nearly 60,000 people were treated at Mount Sinai as inpatients, and there were nearly 450,000 outpatient visits to the Medical Center. Mount Sinai School of Medicine is internationally recognized as a leader in groundbreaking clinical and basic science research, as well as having an innovative approach to medical education….Read the Full Story

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Max Planck scientists develop gene switch for chloroplasts in plant cells

Story Summary: These RNA molecules are the instruction manuals that show the ribosomes – the cells protein factories – how to build a protein. A few years ago, scientists studying bacterial cells discovered sections in certain messenger RNAs that metabolic products (metabolites) can bind to. The scientists smuggled a gene into the chloroplast DNA and equipped it with a riboswitch. Thats because each tobacco cell contains as many as 100 chloroplasts. As a result, it is capable of building more proteins than the DNA in the cell nucleus. In many cases, however, these foreign proteins damage cellular metabolism or photosynthesis if the cells produce them continuously. Foreign genes have another advantage in the chloroplasts besides this: they are inherited almost without exception through the female egg cell. It is therefore extremely rare for foreign genes to spread through the pollen of the tobacco plants. Source: Max-Planck-Gesellschaft– 27 July 2009Researchers have developed a new technique that allows them to make a movie of bacteria infecting their living host. — full story– 9 July 2009Although the fact that we generate new brain cells throughout life is no longer disputed, their purpose has been the topic of much debate. — full story– 8 July 2009The Wildlife Conservation Society (WCS) announced today the discovery of a new monkey in a remote region of the Amazon in Brazil. The monkey is related to saddleback tamarins, which….Read the Full Story

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BioNanomatrix Announces Issuance of Key Nanochannel Array Patent for High Throughput Macromolecular Analysis

Story Summary: Also disclosed are methods of preparing nanochannel array chips, methods of analyzing macromolecules such as entire strands of genomic DNA, and systems for implementing these methods. Dr. Han Cao, the Companys founder and chief scientific officer, said: This patent covers the fundamental method and device for isolating, imaging, and analyzing nucleic acid biopolymers confined within nanoscale fluidic channels. We are very excited about the official issuance of this key patent, which places BioNanomatrix in the forefront of this emerging field. Single molecule analysis of intact native DNA has been limited by the difficulty of linearizing and manipulating these long, complex molecules. To address these limitations, a Princeton University research team, including Dr. Cao, developed a simple approach that uses a nano-fluidic chip to untangle and guide individual molecules into an array of nanochannels. It is designed to provide ultra high-resolution analyses of macromolecules, such DNA and proteins, and their interactions more rapidly, comprehensively, and cost effectively than currently available approaches. BioNanomatrix is the worldwide exclusive licensee of the technology covered by this patent. The companys platform technology permits users to image directly and analyze very long strands of DNA in real time at the single-molecule level, at both high resolution and very high throughputs. This technology has the potential to increase the utility of whole genome imaging and analysis for a wide range of research and diagnostic applications, providing fast, comprehensive and low-cost analysis of genomic, epigenomic and proteomic information. Note: NanoAnalyzer is a registered trademark of BioNanomatrix, Inc. The names of other companies, other entities, products and/or services mentioned herein may be the trademarks of their respective owners. com or Tamara Bright tbright@tiberendstrategicadvisors….Read the Full Story

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