Causes Of Inflammation | Women to Women

Posted: June 1, 2015 at 1:42 am

by Marcelle Pick, OB/GYN NP

Systemic or chronic inflammation has a domino effect that can seriously undermine your health. So how does it all begin?

Many experts now see inflammation as arising from an immune system response thats out of control. When you catch a cold or sprain your ankle, your immune system switches into gear. Infection or injury trigger a chain of events called the inflammatory cascade. The familiar signs of normal inflammation heat, pain, redness, and swelling are the first signals that your immune system is being called into action. In a delicate balance of give-and-take, inflammation begins when pro-inflammatory hormones in your body call out for your white blood cells to come and clear out infection and damaged tissue. These agents are matched by equally powerful, closely related anti-inflammatory compounds, which move in once the threat is neutralized to begin the healing process.

Acute inflammation that ebbs and flows as needed signifies a well-balanced immune system. But symptoms of inflammation that dont recede are telling you that the on switch to your immune system is stuck. Its poised on high alert even when you arent in imminent danger. In some cases, what started as a healthy mechanism, like building scar tissue or swelling, just wont shut off.

Are you walking around on simmer? Just yesterday I saw Nancy, a patient who has been with me for years. When she first came to see me, her triglycerides were sky-high (in the 400s!), her cholesterol was elevated, and she was overweight, unhappy and stressed. Her face was flushed and chapped, her lips were dry, and she seemed fluttery and agitated. On the surface she looked like a heart disease candidate, but when I probed deeper I saw a woman on fire from the inside out.

Currently there is no definitive test for inflammation the best that conventional medicine can do is measure blood levels of C-reactive protein (a pro-inflammatory marker) and the irritating amino acid called homocysteine. I use the high-sensitivity CRP test now available at most labs. Anything above 1 mg/dL with this test is too high in my book. With the older tests a reading of between 25 mg/dL was considered normal. (If youve been tested, be sure to ask your doctor for the results). Newer ways to assess risk early on for future inflammatory disease include markers such as the apolipoprotein B to A1 ratio (ApoB/ApoA-1). This and other tests are in experimental use and only available through a few labs.

When I first ran Nancys tests, I was surprised to see that her CRP levels were normal (this was before the high-sensitivity CRP test was widely available as it is today). This was good news for her heart, since elevated CRP and cholesterol increase your risk of heart disease threefold. But her homocysteine levels were high and all of her other symptoms pointed to inflammation. I prescribed an anti-inflammation diet, essential fatty acids, other anti-inflammatory supplements, and a daily exercise regime (for more information, read our article Reducing Inflammation The Natural Approach.) When Nancy next came in, her triglycerides were down by 200 points, her skin was clear, and her mood was much better. Later tests revealed her cholesterol had gone down, too.

A year went by, and as Nancy entered a stressful period in her life, she again began snacking on unhealthy food and going for days without exercise. Her cholesterol crept back up and she started having irritable bowel symptoms. After a brief pep talk, she got back on track and today shes feeling great. When I saw her yesterday she looked like a different person. Her blood tests all looked good and her inflammation was back under control. Nancys fires are well-tended now, and I feel confident she knows what to do if they start to flare up again.

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Causes Of Inflammation | Women to Women

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