Research finds new proof about the systems controlling skin repair and regeneration – Microbioz India
Posted: January 23, 2021 at 6:49 pm
As the air continues to dry and temperatures drop, the yearly battle against dry hands and skin has officially begun. New research from Northwestern University has discovered new evidence deep within the skin about the mechanisms controlling skin renewal and repair.
Skins barrier function gives it the unique ability to fight winter woes and keep water for our bodies. The outer layer of the skin, the skin, is constantly turning over to replace damaged or dead cells, creating new cells to reinforce the barrier function and heal damage. The gene regulatory mechanisms that control epidermis turnover remain incompletely understood.
Every month were covered with a new layer of the epidermis, said Northwesterns Xiaomin Bao, who headed the study. The next question is what does that procedure involve?
The newspaper will be published on Jan. 19 in the journal Nature Communications.
GeneticjunkThe scientific community has developed a wide breadth of knowledge about proteins, the workhorses of various cellular activities. Many mysteries remain about the nature of introns, non-coding segments of DNA that make up 24% of the human genome.
Regardless of the general belief that introns are nothing butgenetic junk, they actually play critical roles in modulating RNA transcription throughout a tissues lifespan. RNA transcription is the first step of gene expression, in which the data from DNA is copied into RNA, which is then subsequently used as a template for synthesizing proteins to drive the specific function of a cell.
Based on where transcription terminates within an intron or at the conclusion of a gene an epidermal stem cell will either remain a stem cell or become a specified cell barrier function. Bao said while its well-known that transcription ends at the end of a gene, her labs research found conflicting data.
Future research could have implications for carcinoma research.
Technology critical to the discovery of the phenomenonSkin cells are gaining popularity with researchers in part because of their regenerative properties and readiness to grow in cultures. This allows researchers to apply an assortment of state-of-the-art technologies. By growing skin cells and regenerating skin tissue in a petri dish, the Bao Lab can experiment with this fast-growing tissue to determine molecular mechanisms and regulatory elements within DNA.
Technology development is an integral driver that enabled us to uncover this new phenomenon, Bao said.
The group used a novel genomic technique that maps where transcription stops. The integration of proteomic approaches identified RNA-binding proteins which read specific regulatory sequences in the introns.
The team further leveraged CRISPR technologies to delete genomic sequences in the intron, which provided direct evidence demonstrating that the crucial roles of introns in modulating gene expression.
Before this study, mechanisms between introns to govern the switch between a skin stem cell and a terminally differential state (for example, a cell that participates in forming a skin barrier), were unknown. Most studies ignored introns, despite them accounting for 10 to 20 times more sequences than the protein-coding regions (exons) in the human genome.
The study demonstrates that different genes may involve different sets of RNA-binding proteins to recognize the regulatory sequences in their introns. These RNA-binding proteins help to mature RNAdecide whether to cut transcription early or dismiss termination sites within an intron during differentiation due to changes in protein availability.
We are only starting to appreciate the roles of the intron in human health and diseases, Bao said.
Results of this study could have broader impacts because, according to Bao, the procedures regulating skin cells are almost definitely not restricted to skin cells. Future research on other systems, including other epithelial tissues, will likely uncover similar patterns.
We are extremely hopeful that what weve found is the first step to knowing what we have ignored in the past, Bao said. My students also wish to know more about the RNA binding proteins which provide specificity in governing which site to use to terminate transcription.
Source:
Originally posted here:
Research finds new proof about the systems controlling skin repair and regeneration - Microbioz India
- A dive into the genetic history of India, and the role of vitamin A in skin repair - Science - March 12th, 2024
- Vitamin A could have a key role in both stem cell biology and wound healing: Study - Medical Dialogues - March 12th, 2024
- Fiona M. Watt receives the 2024 ISSCR Achievement Award for her seminal work with skin stem cells - EurekAlert - February 13th, 2024
- Eggs from men, sperm from women: Stem cell therapy may just turn reproduction upside down! - The Economic Times - January 20th, 2024
- Herbosa: Clinic under probe after skin treatments linked to womans death - Philstar.com - January 20th, 2024
- These Will Be the Biggest Skin-Care Trends of 2024 - Allure - December 25th, 2023
- Defence Mechanisms: Four ways your body is protecting you every time you fall sick - indulgexpress - May 13th, 2023
- Treat Yourself to a Spa Day With a $100 Deal on $600 Worth of Products From Elemis, 111SKIN, Nest & More - E! NEWS - May 13th, 2023
- Cell-Based Regenerative Medicine Market Size to Witness Rapid Growth at a CAGR of 15% by 2032 | insightSLICE - EIN News - May 5th, 2023
- Best EGF Serum (Epidermal Growth Factor Serum) In 2023: Discover the Ultimate In Skin Rejuvenation - Outlook India - April 18th, 2023
- 7-year-old vows to find a cure for brother in need of bone marrow transplant - WJLA - February 26th, 2023
- 10th Annual Regenerative Medicine Essentials Course and World Stem Cell Summit Return to Live with Virtual Option in 2023 - Newswise - February 10th, 2023
- Leukaemia signs and symptoms: How to detect, treat the aggressive blood cancer - Hindustan Times - February 10th, 2023
- Adult stem cell - Wikipedia - December 28th, 2022
- Stem cells: a brief history and outlook - Science in the News - December 28th, 2022
- What are totipotent stem cells & what can they do? - The Niche - December 28th, 2022
- Certain Foods Discovered to Increase Stem Cells, Cell Regeneration - December 28th, 2022
- Skin Cell - The Definitive Guide | Biology Dictionary - December 28th, 2022
- Women are using menstrual blood for skincare here's why I think beauty has gone too far this time - VOGUE India - December 4th, 2022
- Mesenchymal Stem Cells | Properties, Process, Functions, & Therapies - November 26th, 2022
- Childbirth - Wikipedia - November 26th, 2022
- Unlocking the Mysteries of Brain Regeneration Groundbreaking Study Offers New Insight - SciTechDaily - September 30th, 2022
- TikTok Made Me Buy It: The Creamy Concealer That Instantly Veils Dark Circles and Hyperpigmentation - Vogue - September 30th, 2022
- Here Is Why You Heal Slower As You Age - Health Digest - September 30th, 2022
- A glimpse into Indian consumers expectations for cosmetic treatments and consumption insights - The Financial Express - September 30th, 2022
- Propanc Biopharma Targets Pancreatic & Ovarian Cancers for PRP Clinical Studies with Combined Markets to Reach Over $14.3 Billion by 2027 -... - September 30th, 2022
- Hair-bearing human skin generated entirely from pluripotent stem cells - September 13th, 2022
- FACTORFIVE Skincare The Power of Stem Cells for Skin - September 13th, 2022
- Stem cells: Sources, types, and uses - Medical News Today - September 13th, 2022
- Hematopoietic Stem Cells | Hematopoiesis | Properties & Functions - September 13th, 2022
- Top 3 grants in regenerative medicine: July 2022 - RegMedNet - September 13th, 2022
- Beauty maybe be skin deep, but AI finds revenue on the faces surface - Biometric Update - September 13th, 2022
- September is Blood Cancer Awareness Month: All You Need to Know - News18 - September 13th, 2022
- 10 Facts That Prove Memory Is Not What You Think - Listverse - September 13th, 2022
- Seagen, Astellas and Merck Announce Results of Clinical Trial Investigating PADCEV (enfortumab vedotin-ejfv) with KEYTRUDA (pembrolizumab) and PADCEV... - September 13th, 2022
- NYC Dermatologist, Dr. Julie Russak, launches first Anti-Aging Wellness Program of its kind in the U.S. - PR Web - September 13th, 2022
- Curbing COVID-Related Hair Loss: Russak Dermatology's Hair Restoration Therapy - PR Web - August 11th, 2022
- Jennifer Aniston And Sandra Oh Swear By This Moisturizer That Shoppers Say Created Permanent Changes To Their Skin - Suggest - August 11th, 2022
- Victoria Beckham and Kim Kardashian are fans of Augustinus Baders skincare range - and you can get 20% off - The Mirror - August 11th, 2022
- How your intestines repair and renew themselves - Futurity: Research News - August 3rd, 2022
- Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells | Communications Biology - Nature.com - August 3rd, 2022
- Global Stem Cells Group Expands Its Stem Cell Therapy and Regenerative Medicine Centers to Indonesia - GlobeNewswire - August 3rd, 2022
- NuFace Is Having a Major Sale During Amazon Prime Day 2022 See Deals on Trinity, NuBody, and More - Allure - July 17th, 2022
- Global Stem Cell Manufacturing Market Value Projected To Reach USD 21.71 Billion By 2029, Registering A CAGR Of 9.1% - Digital Journal - July 17th, 2022
- The 'Benjamin Button' effect: Scientists can reverse aging in mice. The goal is to do the same for humans - KITV Honolulu - July 17th, 2022
- Why do some women struggle to breastfeed? A UCSC researcher on what we know, and don't - Lookout Santa Cruz - July 17th, 2022
- What if we could genetically dial back our skin? - The Week - June 28th, 2022
- Reviewers Are Calling This Hydrating Stem Cell Cream Miraculous - Us Weekly - June 28th, 2022
- UVR Promotes Keratinocyte Phagocytosis and Skin Pigmentation Through T | CCID - Dove Medical Press - June 28th, 2022
- 'A new Alzheimer's treatment is on the horizon': Cell therapy reverses dementia-like syndrome in dogs - BioPharma-Reporter.com - June 28th, 2022
- What Is Vegan Collagen? And the 6 Best Products to Try - VegNews - June 28th, 2022
- Shock Wave Uses and Benefits The Horse - TheHorse.com - June 28th, 2022
- Chao Discusses Stratifying and Treating Patients With Graft-Vs-Host Disease - Targeted Oncology - June 28th, 2022
- Elucidating the developmental origin of life-sustaining adrenal glands | Penn Today - Penn Today - May 24th, 2022
- All Things Hot In The Beauty Space In The Month Of May | Femina.in - Femina - May 24th, 2022
- Anti-Aging Products and Therapies Market Size Estimated to Reach $93.2 Billion by 2027 - Digital Journal - April 2nd, 2022
- Learning from the single cell: A new technique to unravel gene regulation - EurekAlert - April 2nd, 2022
- Sailing the Genome in Search of Safe Harbors - Technology Networks - April 2nd, 2022
- 7 Easy Ways to Transition Your Skin Care Routine for Spring - Vancouver Magazine - April 2nd, 2022
- INTERNATIONAL STEM CELL CORP MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS (form 10-K) - Marketscreener.com - April 2nd, 2022
- Syrian refugee is thriving five years after last-gasp gene therapy - STAT - STAT - December 9th, 2021
- Benefits of Pulsed Laser-based Skin Therapy - Newswise - December 9th, 2021
- Mesoblast has long been the one poster child for stem cell therapy. Now Cynata and other ASX stocks have e ... - Stockhead - December 9th, 2021
- In This Issue - pnas.org - December 9th, 2021
- UNM research team finds lungfish cocoon is living tissue with antimicrobial functions - UNM Newsroom - December 9th, 2021
- Mini-brain model of frontotemporal dementia demonstrates the stages of dysfunction that lead to cell death - National Institute on Aging - November 7th, 2021
- A major research project to advance regenerative therapy for epidermolysis bullosa (EB) using transgenic stem cells - PR Web - November 7th, 2021
- 15 Best Peptide Skin-Care Products 2021 for Smoother, Firmer, and Plumper Skin - Allure - November 7th, 2021
- Lab-Growing Everything Might Be The Only Way To Attain A Sustainable World - Intelligent Living - November 7th, 2021
- Common But Overlooked Causes for Hair Loss - The Cherokee Scout - November 7th, 2021
- How To Look Less Tired According To Experts | Grazia - Grazia - November 7th, 2021
- Losing Your Hair? You Might Blame the Great Stem Cell Escape. - The New York Times - October 5th, 2021
- Stem cells may be the key to saving white rhinos from extinction - Sciworthy - October 5th, 2021
- The Best Skincare Treatments For Time-Crunched Moms (Or Anyone Else Who Only Has Five Minutes To Spare) - Forbes - October 5th, 2021
- Stanford neuroscientist's 'assembloids' pave the way for innovative brain research - Scope - October 5th, 2021
- 3 of the Best Fall Beauty Buys - Pursuitist - October 5th, 2021
- Can Obesity Lead to Hair Fall? Here's What The Research Says - India.com - October 5th, 2021
- 12 of the best face serums 2021 - Medical News Today - October 5th, 2021
- The Number 1 Serum in the U.S. Is on Sale at SaksAlong With Other Never-Discounted Buys - Well+Good - October 5th, 2021
- Man discovers nasty red rash on his hands and elbows is potentially fatal - The Mirror - October 5th, 2021