What to grow first?
Finally picked the seeds I will be starting for my first indoor garden. I will be going with TGA #39;s Cheese Quake and a fem OG Kush to give me my sixth plant. ...

By: JS Maine

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What to grow first? - Video

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Genetics - Watcher of the Skies @ Teatro Coliseo, Bs As, 21/09/13.
Genetics - Watcher of the Skies (Foxtrot, 1972). Teatro Coliseo, Bs As, Argentina. Sábado 21 de Septiembre de 2013. HD Stereo.

By: Gino Zolezzi

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Genetics - Watcher of the Skies @ Teatro Coliseo, Bs As, 21/09/13. - Video

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Genetics - Dancing with the Moonlit Knight @ Teatro Coliseo, Bs As, 21/09/13.
Genetics - Dancing with the Moonlit Knight (Selling England by the Pound, 1973). Teatro Coliseo, Bs As, Argentina. Sábado 21 de Septiembre de 2013. HD Stereo.

By: Gino Zolezzi

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Genetics - Dancing with the Moonlit Knight @ Teatro Coliseo, Bs As, 21/09/13. - Video

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Genetics part 2 nonmendelian inheritance (codominance, polygene, linked gene, sex linkage etc.)
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Non-M...

By: Suman Bhattacharjee

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Genetics part 3 incomplete dominance and codominance
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Incom...

By: Suman Bhattacharjee

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Genetics problems 8 duplicate dominant epistasis
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Genetics (from Ancient Greek ????????...

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Genetics problems 11 sex linked inheritance
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Genet...

By: Suman Bhattacharjee

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Redline Genetics, Day 22 Flower 10 02 13
The plants I in this video are in compliance with the laws of my state. Special thanks to Redline Genetics. redlinegenetics.com.

By: Primo Kush

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This is a rare photo of a Bryde's whale breaching off of Bangladesh. Credit: WCS-Bangladesh

Published: Oct. 3, 2013 at 4:21 PM

NEW YORK, Oct. 3 (UPI) -- A genetic study of a species of whales sometimes targeted by Japan's scientific whaling program could aid management strategies for the animals, scientists say.

The study has helped define populations and subspecies of Bryde's whale, a medium-sized and poorly understood baleen whale, the Wildlife Conservation Society reported Thursday.

The research has confirmed the existence of two subspecies -- a larger variety that inhabits offshore waters and a smaller subspecies that frequents more coastal marine habitats.

"Very little is known about Bryde's whales in terms of where populations are distributed, the extent of their range, or even relationships among them at the population, subspecies and species levels," Columbia University researcher Francine Kershaw, lead author of the study, said. "Our genetic research will help define these groups and identify populations in need of additional protection."

Bryde's whales can grows to 50 feet in length and are found in tropical, subtropical, and warm temperate waters of the Atlantic, Pacific and Indian Oceans.

In addition to the impact of scientific whaling carried out by Japan, Bryde's whale populations are at risk from ship strikes, fisheries bycatch, hydrocarbon exploration and development in coastal waters, the researchers said.

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Genetics helps identify hunted, and poorly known, whale species

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A Vaccine for AIDS: Promising Research at OHSU
Date: September 27, 2013 Speakers: Dr. Louis Picker, Associate Director of OHSU #39;s Vaccine and Gene Therapy Institute and Charles Wilhoite, Chair of the OHSU Board of Directors Thank you co-presen...

By: City Club of Portland

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BMB Gene Therapy

By: Mark Kim

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BMB Gene Therapy - Video

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Cecilia Lundberg, Professor of Neuroscience, Lund University / MultiPark
Cecilia Lundberg #39;s research group is focused on developing vectors for use in gene therapy to treat diseases in the brain. Furthermore, they also aim to expl...

By: MULTIPARK

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Cecilia Lundberg, Professor of Neuroscience, Lund University / MultiPark - Video

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DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/nxqb6r/rosacea) has announced the addition of the "Rosacea - Pipeline Review, H2 2013" report to their offering.

'Rosacea - Pipeline Review, H2 2013', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Rosacea, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Rosacea.

Scope

- A snapshot of the global therapeutic scenario for Rosacea.

- A review of the Rosacea products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.

- Coverage of products based on various stages of development ranging from discovery till registration stages.

- A feature on pipeline projects on the basis of monotherapy and combined therapeutics.

- Coverage of the Rosacea pipeline on the basis of route of administration and molecule type.

- Key discontinued pipeline projects.

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Research and Markets: Rosacea - Pipeline Review, H2 2013

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Home Mail News Sports Finance Weather Games Groups Answers Screen Flickr More omg! Shine Movies Music TV Health Shopping Travel Autos Homes Mobile Yahoo News Search News Search Web Sign In Mail Help Account Info Help Suggestions Yahoo News Home Video Photos GMA Year in Review Odd Comics Travel Opinion Trending Now Who Knew? Weather The Upbeat U.S. U.S. Video GMA Education Religion Crimes and Trials Local Contributor Network Year In Review World World Video Middle East Europe Latin America Africa Asia Canada Australia/Antarctica Business Video Exclusives Today's Markets Stocks Personal Finance Marketplace Entertainment Video Clinton Concert Celebrity TV Movies Music Fashion Books Arts Theater Dear Abby Comics Odd News Sports Video NFL MLB NBA NCAAF NCAAB Soccer Cycling NHL Tennis Golf Boxing Motor Sports MMA Olympics Tech Gadgets Wireless Apple Social Media Security Open Source Gaming Apps This Could Be Big Upgrade Your Life Politics Remake America The Issues Women and Politics Press Releases Video Science Science Video Weather News Space / Astronomy Pets Dinosaurs / Fossils Biotech Energy Green Health Video Weight Loss Cancer Sexual Health Medications/Drugs Parenting/Kids Seniors/Aging Diseases/Conditions Blogs The Sideshow Katie's Take Power Players This Could Be Big Newsmakers Trending Now The Upbeat Who Knew? Nightline Fix Beyond the Headline Local Popular Search Keyword News Search

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Gene scans solve mystery diseases in kids, adults

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DUBLIN--(BUSINESS WIRE)--Research and Markets (http://www.researchandmarkets.com/research/2zlwxm/rnai) has announced the addition of Jain PharmaBiotech's new report "RNAi - Technologies, Markets and Companies" to their offering.

RNA interference (RNAi) or gene silencing involves the use of double stranded RNA (dsRNA). Once inside the cell, this material is processed into short 21-23 nucleotide RNAs termed siRNAs that are used in a sequence-specific manner to recognize and destroy complementary RNA. The report compares RNAi with other antisense approaches using oligonucleotides, aptamers, ribozymes, peptide nucleic acid and locked nucleic acid.

Various RNAi technologies are described, along with design and methods of manufacture of siRNA reagents. These include chemical synthesis by in vitro transcription and use of plasmid or viral vectors. Other approaches to RNAi include DNA-directed RNAi (ddRNAi) that is used to produce dsRNA inside the cell, which is cleaved into siRNA by the action of Dicer, a specific type of RNAse III. MicroRNAs are derived by processing of short hairpins that can inhibit the mRNAs. Expressed interfering RNA (eiRNA) is used to express dsRNA intracellularly from DNA plasmids.

Delivery of therapeutics to the target tissues is an important consideration. siRNAs can be delivered to cells in culture by electroporation or by transfection using plasmid or viral vectors. In vivo delivery of siRNAs can be carried out by injection into tissues or blood vessels or use of synthetic and viral vectors.

Because of its ability to silence any gene once the sequence is known, RNAi has been adopted as the research tool to discriminate gene function. After the genome of an organism is sequenced, RNAi can be designed to target every gene in the genome and target for specific phenotypes. Several methods of gene expression analysis are available and there is still need for sensitive methods of detection of gene expression as a baseline and measurement after gene silencing. RNAi microarray has been devised and can be tailored to meet the needs for high throughput screens for identifying appropriate RNAi probes. RNAi is an important method for analyzing gene function and identifying new drug targets that uses double-stranded RNA to knock down or silence specific genes. With the advent of vector-mediated siRNA delivery methods it is now possible to make transgenic animals that can silence gene expression stably. These technologies point to the usefulness of RNAi for drug discovery.

The markets for RNAi are difficult to define as no RNAi-based product is approved yet but several are in clinical trials. The major use of RNAi reagents is in research but it partially overlaps that of drug discovery and therapeutic development. Various markets relevant to RNAi are analyzed from 2012 to 2022. Markets are also analyzed according to technologies and use of siRNAs, miRNAs, etc.

Profiles of 161 companies involved in developing RNAi technologies are presented along with 231 collaborations. They are a mix of companies that supply reagents and technologies (nearly half of all) and companies that use the technologies for drug discovery. Out of these, 33 are developing RNAi-based therapeutics and 35 are involved in microRNAs. The bibliography contains selected 600 publications that are cited in the report. The text is supplemented with 37 tables and 11 figures.

Key Topics Covered:

Executive Summary

1. Technologies for suppressing gene function

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Research and Markets: Global RNAi Market Report 2013-2022: Updated Technologies, Markets and Companies Analysis

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Public release date: 2-Oct-2013 [ | E-mail | Share ]

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, October 1, 2013People suffering from post-traumatic stress disorder (PTSD) face a greater risk of cardiovascular disease and death. A new study involving a comprehensive review of the medical literature shows that PTSD also increases an individual's risk of metabolic syndrome. What links these two disorders is not clear, according to a study published in Metabolic Syndrome and Related Disorders, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Metabolic Syndrome and Related Disorders website at http://www.liebertpub.com/met.

Francesco Bartoli and coauthors from University of Milano-Bicocca, Italy, University College London, UK, and San Gerardo Hospital, Monza, Italy, conducted a systematic review and meta-analysis and, based on their findings, propose that the increased risk of metabolic syndrome may result from neurological and hormonal responses to chronic stress. Their study is entitled "Metabolic Syndrome in People Suffering from Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis."

In an accompanying Editorial, "Posttraumatic Stress Disorder and Metabolic Syndrome: More Questions than Answers," authors Dawn Schwenke, PhD, VA Health Care System and Arizona State University, Phoenix, and David Siegel, MD, Northern California Health Care System (Mather) and University of California, Davis, suggest that more research is needed to determine whether the relationship between PTSD and metabolic syndrome is independent of other factors such as socioeconomic status, diet, physical activity, smoking, alcohol consumption, and insomnia.

"While Bartoli and colleagues conclude from their meta-analysis that PTSD confers a greater risk for metabolic syndrome, Schwenke and Siegel in their editorial suggest caution, explaining that it is not a simple relationship and many confounding factors could explain this," says Ishwarlal (Kenny) Jialal, MD, PhD, Editor-in-Chief of the Journal and Distinguished Professor of Pathology and Laboratory Medicine and Internal Medicine (Endocrinology, Diabetes and Metabolism), Robert E. Stowell Endowed Chair in Experimental Pathology, Director of the Laboratory for Atherosclerosis and Metabolic Research, Director Special Chemistry and Toxicology, Davis Medical Center (Sacramento). "In agreement with the latter, I believe this is a fertile area for further investigation before any definite conclusions can be drawn."

###

About the Journal

Metabolic Syndrome and Related Disorders is the only peer-reviewed journal to focus solely on the pathophysiology, recognition, and treatment of metabolic syndrome. The Journal covers a range of topics including insulin resistance, central obesity, glucose intolerance, dyslipidemia with elevated triglycerides, predominance of small dense LDL-cholesterol particles, hypertension, endothelial dysfunction, and oxidative stress and inflammation. In 2014, the Journal will be published 10 times per year. Tables of content and a sample issue may be viewed on the Metabolic Syndrome and Related Disorders website at http://www.liebertpub.com/met.

About the Publisher

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Does post-traumatic stress disorder increase the risk of metabolic syndrome?

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Public release date: 2-Oct-2013 [ | E-mail | Share ]

Contact: Raquel Maurier rmaurier@ualberta.ca 780-492-5986 University of Alberta Faculty of Medicine & Dentistry

A genetic condition that attacks multiple organs and usually results in fatal heart problems can be detected using a new MRI technique that was developed at the University of Alberta. The discovery of this new diagnostic tool has resulted in updated clinical guidelines for the diagnosis and treatment of Fabry disease in Canada.

Faculty of Medicine & Dentistry researchers Gavin Oudit and Richard Thompson worked with Faculty colleagues Kelvin Chow and Alicia Chan on the discovery, as well as Aneal Khan from the University of Calgary. The findings were recently published in the peer-reviewed journal, Circulation Cardiovascular Imaging, and involved 31 Alberta patients who have the disease.

Thompson and trainee Chow developed the MRI technique known as T1 mapping which can detect heart damage and changes at early stages earlier than regular MRI scans or ultrasound. When this type of MRI is used on patients with Fabry disease, the scans can detect both the disease and the severity of damage to the heart. The T1 mapping method developed by Thompson's group can be easily programmed onto MRIs around the world.

"This test can uniquely identify Fabry disease by detecting microscopic changes in the heart muscle structure that are not visible on regular images," says Thompson, who works in the Department of Biomedical Engineering. "Fabry disease can look like other diseases if you only look at the whole heart structure or function, but this T1 mapping test, that can detect the tiniest changes in the heart, could identify all the patients with Fabry disease."

Oudit added: "It is very likely that this technique will become a key part in clinical examination of patients with Fabry disease. This finding will advance the clinical care of these patients around the world. The implications will be widespread.

"Heart disease is the number one cause of death for patients with Fabry disease. The earlier the disease can be pinpointed, the sooner treatment can start. The treatment for the disease halts the condition and prevents serious damage to the heart."

Fabry disease is a genetic metabolic condition that destroys the enzyme involved in fat metabolism. This enzyme breaks down fat so without it, those with the disease accumulate deadly fat deposits in their heart, kidneys and brain. The condition affects 1 in 1,500 to 3,000 people, but was originally thought to be a rare disease. Some countries now screen newborns for the condition that costs $200,000 a year to treat through monthly infusions called enzyme replacement therapy. Symptoms of the disease include: heart failure, thickened walls of the heart, exercise intolerance, fluid buildup in the legs, blackouts, inability to lie down, strokes, tingling in the hands and feet, and changes in skin pigmentation.

It is estimated that about 1,000 Albertans are living with the disease but not everyone who has the condition has been diagnosed. Sometimes people will see scores of kidney and heart specialists for years before anyone diagnoses the condition. Men can have a blood test to identify the condition, while women who may also carry the disease without showing symptoms need to undergo genetic testing. The T1 mapping test can both pinpoint the disease and assess damage to the heart.

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New MRI technique can detect genetic condition that attacks the heart, brain and nerves

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Oct. 1, 2013 The discovery of genetic differences affecting up to a third of the population could take the guesswork out of prescribing the correct dose of 25 percent of drugs currently on the market, researchers say.

The scientists found two genetic variants that alter the activity level of an enzyme responsible for processing, or metabolizing, drugs ranging from the painkiller codeine to the breast cancer drug tamoxifen.

The Ohio State University researchers who found these differences say that pending additional research, the variants are good candidates for inclusion in an existing biomarker test that guides drug dosing.

The current test is designed to determine the enzyme's activity level, or expression, to predict whether a patient will fall into one of four categories: poor, intermediate, extensive or ultra-rapid metabolizer. Metabolism speed affects how much medicine a patient needs.

But there are limits to the existing test: The current biomarker panel is based on variants that have been associated with how patients respond to different doses of drugs.

The researchers who found these previously unidentified variants, however, have determined the specific effects that the variants have on drug metabolism. One reduces the enzyme's activity twofold by turning off a function of its gene, and the other is located in an enhancer region of the gene, meaning it increases the enzyme's expression between two- and fourfold.

"If you don't consider these two variants, the current biomarker panel can cause incorrect dosing," said senior author Wolfgang Sadee, professor and chair of pharmacology and director of the Center for Pharmacogenomics at Ohio State. "The better the test, the more value it has. Adding these variants to the panel would make the test more predictive and robust with respect to application in the clinic."

Ohio State has applied for a patent on the addition of these variants to a clinical biomarker test.

The research is published online in the journal Human Molecular Genetics.

The study included a clinical trial of 164 children, about one-third of whom were African American. The results show that these two variants are common in both Caucasians and African Americans, and confirmed that the variants influence how patients metabolize the cough suppressant dextromethorphan.

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New genetic discovery could reduce the guess work in drug dosing

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Marton Genetics Kukoricabemutató 2013. szeptember
Mint minden évben, az idén is több száz látogató el?tt rendezték meg szeptember 5-én Martonvásáron a kukorica-fajtabemutatót. Azonban az idei rendezvény külö...

By: Marton Genetics

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Marton Genetics Kukoricabemutató 2013. szeptember - Video

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World-leading expert on pain genetics joins McGill
Dr. Luda Diatchenko, a world leader in pain genetics, joins McGill University as Canada Excellence Research Chair (CERC) in Human Pain Genetics. She is joini...

By: McGill University

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World-leading expert on pain genetics joins McGill - Video

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Genetics in Primary Care
MGMC Physician Grand Rounds Nathan Noble, DO Blank Children #39;s Developmental Center.

By: Mary Greeley

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Genetics in Primary Care - Video

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Let #39;s Play The Sims 3 - Perfect Genetics Challenge - Episode 29
My Sims 3 Page: http://mypage.thesims3.com/mypage/Llandros2012 My Blog: http://Llandros09.blogspot.com My Facebook: https://www.facebook.com/Llandros09?ref=t...

By: Llandros09

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Genetics part 5 multiple alleles (dominant and recessive)
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html.

By: Suman Bhattacharjee

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Genetics part 5 multiple alleles (dominant and recessive) - Video

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Genetics part 7 epistasis (dominant, recessive, double dominant etc.)
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html In ge...

By: Suman Bhattacharjee

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Genetics part 7 epistasis (dominant, recessive, double dominant etc.) - Video

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23andMe says it has no plans to pursue concepts discussed in its patent for a method to predict a baby's traits based on its parents' DNA

By Ewen Callaway and Nature News Blog

Image: 23andMe

Showcasing more than fifty of the most provocative, original, and significant online essays from 2011, The Best Science Writing Online 2012 will change the way...

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Originally posted on the Nature news blog

The consumer genetics firm 23andMe was last week awarded a US patent for a method to predict a babys traits based on its parents DNA, the company announced.

23andMe, which is based inMountain View, California, says that the patent relates to its Family Traits Inheritance Calculator, which offers an engaging way for you and your partner to see what kind of traits your child might inherit from you and has been available to customers since 2009. Yet the patent (PDF here), which was filed more than 5 years ago, includes language that mentions other applications of the method, including for the screening of sperm and ova to be used for in vitro fertilization. The patent mentions the potential to screen would-be babies for traits such as eye color, disease risk, height and gender.

The company says that it included such language when it filed the patent because it saw the potential for the tool to be used in fertility clinics. But much has evolved in that time, including 23andMes strategic focus. The company never pursued the concepts discussed in the patent beyond our Family Traits Inheritance Calculator, nor do we have any plans to do so, it says.

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Personal-Genetics Firm Denies Pursuit of 'Designer Babies'

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