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Global Gold Snapshot: Eight companies to watch – The Northern Miner

Given the market volatility from the spread of COVID-19, the outlook for gold remains uncertain. Nevertheless, gold exploration and mine development remain important drivers of mining activity. Here are eight companies with exposure to gold and precious metals.

Bear Creek Mining

Bear Creek Minings Corani silver-lead-zinc project in southern Peru. Credit: Bear Creek Mining.

Bear Creek Mining (TSXV: BCM; US-OTC: BCEKF) wholly owns the 57-sq.-km Corani silver-lead-zinc deposit in Perus Andes mountains, 160 km from Cusco.

In November, the company released an updated feasibility study for a potential 27,000 tonne per day open-pit operation, extracting ore from the Este, Minas and Main pits. The study envisioned a mine that would produce an average of 9.6 million oz. of silver, 98 million lb. of lead and 69 million lb. of zinc annually over a 15-year life. With life of mine all-in sustaining costs of US$4.55 per oz. of silver produced and US$579 million in initial capital, the associated projects net present value estimate, at an 8% discount rate, comes in at US$369 million.

Separate zinc and lead concentrates would be produced on site, with additional contained silver for trucking to the Matarani port, located 632 km away.

The latest study includes a contractor mining scenario, with a third-party in charge of ore and waste haulage as well as equipment maintenance. Bear Creek has key permits in place for the shovel-ready project.

The latest study was an update of a report previously completed in 2017. Modifications included a redesign of haul roads, rerouted construction access, a reduced footprint of the process plant and increased throughputs of 27,000 tonnes per day, up from the previous 22,500 tonnes per day.

The total reserve statement for the project is unchanged at 139.1 million tonnes grading 50.3 grams silver per tonne, 0.9% lead, and 0.59% zinc for a total of 225 million oz. silver, 2.7 billion lb. lead and 1.8 billion lb. zinc. Additional measured and indicated resources stand at 96.7 million tonnes grading 27.9 grams silver, 0.38% lead and 0.26% zinc with a further 39.9 million tonnes at 37.2 grams silver, 0.58% lead and 0.4% zinc inferred.

Bear Creek plans to engage in discussions with potential project finance participants to allow its board to make a construction decision. In February, the company closed a $16.6-million bought deal financing.

Bear Creek Mining has a $115.7-million market capitalization.

GoGold Resources

GoGold Resources (TSX: GGD) holds the Parral tailings and Los Ricos projects in Mexico.

The producing Parral project in Chihuahua state features 21.3 million tonnes of tailings from historical mining operations near an urban area. Due to sub-optimal historic recovery flowsheets, significant amounts of both silver and gold remain in this material. A 2013 pre-feasibility study outlined a reserve of 20.3 million tonnes grading 38.4 grams silver per tonne and 0.31 gram gold per tonne for a total of 35 million oz. silver-equivalent.

After an 18-month financing and construction period, GoGold started production activities at the site in June 2014. Subsequently, in February 2015, the company acquired the nearby Esmeralda tailings property, adding measured and indicated resources of 5.8 million tonnes of 49 grams silver and 0.26 gram gold for a further 12.6 million silver-equivalent ounces.

In the fourth quarter of 2019, Parral produced 584,988 silver-equivalent oz. at all-in sustaining costs of US$14.59 per oz. and GoGold expects to maintain this level of output throughout 2020.

In January, the company commissioned a sulphidization-acidification-recycling-thickening (SART) plant at Parral to regenerate the cyanide and produce a copper sulphide product. The SART technology allows companies to manage and recycle process cyanide.

In March of last year, GoGold entered into an option agreement to acquire the 225-sq.-km Los Ricos project in Jalisco state from private owners. In August, the company accelerated the acquisition by paying a total of US$7.1 million for the acquisition in cash and shares over a 24-month period.

Los Ricos features extensive historic underground development with epithermal mineralization. Last year the company completed 17,400 metres of diamond drilling at the site, mostly around historic mining areas.

Latest drill highlights from the site included 21 metres of 219 grams silver-equivalent from the Los Ricos quartz vein within the San Juan area, as well as 10.7 metres of 235 grams silver-equivalent from a shallow hole testing the el Abra outcrop.

Two main exploration efforts are underway at Los Ricos: the South project that includes the Main site area with drilling around historical mines and new targets, and the North project, which includes four targets.

In February, the company closed a $25 million bought deal with proceeds intended for exploration at Los Ricos as well as for corporate purposes.

GoGold has a market capitalization of $86.6 million.

Mako Mining

Mako Mining (TSXV: MKO) is developing the San Albino gold project in Nicaragua, located 173 km north of the capital city of Managua.

The proposed San Albino open pit is high-grade. A 2015 resource estimate and preliminary economic assessment for the project outlined in-pit indicated resources of 656,000 tonnes grading 7.13 grams gold per tonne for a total of 150,400 oz. with additional inferred resources of 880,000 tonnes of 6.78 grams gold totaling 192,000 ounces. A total of 148,600 of these ounces are in oxides with a further, predominantly sulphide, 2.2 million inferred tonnes grading 8.47 grams gold for a total of 595,800 oz. out of pit.

The PEA outlined a 500 tonne per day staged open pit to underground operation at an initial capital cost of $21.1 million, average annual payable gold-equivalent production of 41,300 oz. and all-in gold-equivalent sustaining costs of $395 per ounce. The associated net present value estimate for the project, at a 5% discount rate, came in at US$173.9 million, with a 1.7-year payback period.

In July of last year, the company closed a $27 million rights offering with Wexford Capital, a U.S.-based investment firm and Makos controlling shareholder with a 50.9% stake, to start construction at San Albino. In addition, in February of this year, Mako also closed a US$15.5 million unsecured term loan with Wexford.

Mako provided a mine construction update in November last year. At that time, the company had just purchased a 1,000 tonne per day crusher and was looking at available second-hand mills. Mako started pre-stripping waste at the future San Albino pit in February and said it will start mining of mineralized material this month.

Mako is currently targeting completion of the process plant construction by this summer with a first gold pour expected in late summer.

In September 2017, the company received a permit to construct and operate a mine at the site with throughputs of up to 500 tonnes per day.

San Albino is located within the companys 150-sq.-km land package, which covers a 23-km strike of the Corona de Oro gold belt. The existing deposit remains open both on strike and at depth. In March, Mako released drill results from the Bayacun zone at the Las Conchitas area, about 2.5 km south of the San Albino construction site. Highlight intercepts included 3.1 metres of 32.73 grams gold and 3.4 metres of 30.61 grams gold. Drilling at Las Conchitas this year is aimed at defining near-surface, high-grade mineralization to delineate a resource with additional work planned for high-grade targets within the companys land package.

Mako Mining has a $189.7-million market capitalization.

Minera Alamos

Minera Alamos Santana gold project in Sonora state, Mexico. Credit: Minera Alamos.

Minera Alamos (TSXV: MAI) is developing the wholly owned Santana open-pit heap leach gold project in Mexicos Sonora state, with additional upside from the pre-development La Fortuna asset in the state of Durango.

In January, the company announced that it had started construction activity at the 85 sq. km project, which is estimated to take about six to eight months to complete. This initial operation is forecast to generate approximately 25,000 oz. to 30,000 oz. of gold annually. Minera Alamos currently estimates the capital cost for construction of the heap leach project at approximately $10 million.

The planned Santana mine would have a 5,000 tonne per day to 6,000 tonne per day design capacity. At the end of January, the company entered into a purchase agreement for a crushing, screening and agglomeration system for the mine for staged payments totaling $1.2 million.

In the first quarter, Minera Alamos started preparing for construction of the leach pads and holding ponds. To date, the company has mined about 50,000 tonnes on a trial basis with recovered gold grades at over 0.67 gram gold per tonne.

In December 2019, the company announced a $14 million combined royalty and equity financing package with Osisko Gold Royalties (TSX: OR). The financing included a $6 million private placement, a $5 million sale of a perpetual 3% net smelter return (NSR) royalty on Santana, with a further $3 million available in financing from Osisko during construction and start-up of Santana. Osisko Royalties currently holds 18.7% of the companys shares.

In September 2019, surface rock sampling at the project identified additional gold-silver surface anomalies: the Gold Ridge zone, which has been traced for about 1,000 metres of strike and over widths of 200 metres. This discovery is roughly 2-3 km away from the planned heap leach facilities. In addition to Gold Ridge, exploration targets include the Divisadero, Benjamin and Zata zones where rock samples have also returned anomalous gold values. Drilling is ongoing with plans for approximately 2,500 metres to 3,000 metres in each quarter of this year.

Minera Alamos also holds the 62-sq.-km La Fortuna project in Durango state. A preliminary economic assessment (PEA) from 2018 outlined an open-pit operation producing an average of 50,000 gold-equivalent oz. annually over a five-year mine life. With all-in sustaining costs pegged at US$440 per oz. and a pre-production capital outlay of US$26.9 million, the associated projects net present value estimate, at a 7.5% discount rate, came in at US$69.8 million.

Permitting for La Fortuna is underway with an estimated 12-month build period. Minera Alamos envisions development of this asset once construction at Santana is complete. The company has also identified additional zones of mineralization at the project.

Minera Alamos has a $87.4-million market capitalization.

OceanaGold

A truck exits a portal at OceanaGolds Waihi gold mine on New Zealands North Island. Credit: OceanaGold.

OceanaGold (TSX: OGC) holds three operating gold mines in New Zealand and the U.S. as well as the Didipio gold-copper mine in the Philippines, which suspended processing operations in October.

In 2020, the company expects to produce 360,000 oz. to 380,000 oz. of gold at all-in sustaining costs of US$1,075 to US$1,125 per oz.

The Haile open pit in South Carolina is currently the companys largest production contributor, expected to churn out 180,000 oz. to 190,000 oz. of gold this year at AISCs of US$1,080 to US$1,130 per oz. The mine, which started pouring gold in 2017, has an estimated mine life reaching out to 2033. In the near term, the company is also working towards upping open pit operations through accelerating mining activities, increasing productivities, updating mine plans and deploying a larger mining fleet.

OceanaGold is also completing optimization work on an underground mine plan for the Horseshoe underground with an expansion at Haile in mind. It plans to provide details of these studies in the second half of this year.

The Macraes underground and open pit operations in New Zealand are forecast to contribute 160,000 oz. to 170,000 oz. this year. The complex has been producing for over 29 years and the company is currently targeting a mine life extension at the project through ongoing exploration and planning work. A pre-feasibility study for the Golden Point underground project at the site is underway, expected in the second half of the year.

The companys Waihi underground mine, also in New Zealand, is forecast to produce 18,000 oz. to 20,000 oz. in 2020. Last year, OceanaGold received the go-ahead to develop the Martha Underground within the Waihi district, below the past-producing Martha pit and accessible through existing underground infrastructure, which would extend the life of this mine by at least ten years. First production is expected in the second quarter of next year, and anticipated to ramp up to the 90,000 oz. to 100,000 oz. per year level. Additional exploration is underway at the WKP past-producing project, located 10 km from the Waihi plant; drill results there have included 25.4 metres of 38.7 grams gold per tonne and 8.7 metres of 24.5 grams gold.

At Didipio, governed by a Financial or Technical Assistance Agreement (FTAA) with the Philippine government, the office of the president is currently reviewing the FTAA renewal application, with a notice of renewal submitted in March 2018, but has not issued a decision timeline. The FTAA became renewable for a 25-year term in June 2019. The mine remains in a state of operational readiness. Last year it produced 83,913 oz. of gold and 10,255 tonnes of copper.

OceanaGold has a $777.9-million market capitalization.

Roxgold

The processing plant at Roxgolds Yaramoko gold mine in Burkina Faso. Credit: Roxgold.

Roxgold (TSX: ROXG) is an Africa-focused gold producer and developer with assets in Burkina Faso and Cote dIvoire.

The companys 1,100 tonne per day Yaramoko operation in Burkina Faso, 200 km southwest of Ouagadougou, features the 55 Zone and Bagassi South underground mines. This year, the two operations are expected to produce a total of 120,000 oz. to 130,000 oz. of gold at AISCs of US$930 to US$990 per oz. with similar anticipated production at lower AISCs, in the range of US$750 to US$850 per oz., expected in the two following years.

Yaramokos total reserves are at 2.5 million tonnes grading 8.24 grams gold per tonne for a total of 658,000 ounces. The majority of these are contained within the 55 Zone, an area with a history of resource replacement, where high-grade, dipping shoots have been traced down to a depth of 1.2 vertical kilometres. In the second half of this year, Roxgold plans to complete a 14,000-metre infill program from underground at this site to drill resource extensions at depth and test parallel structures.

In April 2019, Roxgold acquired the Seguela project in Cote dIvoire, 240 km northwest of Yamoussoukro. Current indicated resources for the project are at 7.1 million tonnes grading 2.3 grams gold for a total of 529,000 oz. with and an additional 5.2 million inferred tonnes at 2.8 grams gold containing 471,000 ounces.

Roxgold envisions development of the Antenna deposit at the site with additional contributions from satellite pits situated along the main structures of the Boulder-Agouti trend. In April of last year, the company started a 24,000 metre drill program testing six potential target areas, five of which returned meaningful gold intercepts. Overall, there are 28 targets identified within the Seguela holdings.

Infill and step-out drilling completed at Antenna since the January 2020 resource update has confirmed a high-grade core with extensions to this mineralization at depth and along strike. Highlight intercepts included 11 metres of 3.3 grams gold as well as 28 metres of 1.7 grams gold; both of these start at surface. The results will be incorporated into an upcoming preliminary economic assessment for Seguela, expected in the second quarter of 2020.

On the exploration front, the companys Boussoura project in Burkina Faso, 180 km south of Yaramoko, lies within the Houde gold belt. Boussoura permits cover an area of 250 sq. km with a further 250 sq. km covered by earn-in agreements. Main targets at the site are Fofora in the north and Galgouli in the south: the former hosts artisanal workings over an area of 9 sq. km with over nine veins identified whereas the latter features 1 km of artisanal workings over a primary target vein. Two rigs are currently working at Boussoura.

Roxgold has a $263.8-million market capitalization.

Wesdome Gold Mines

The Kiena mine site in Val DOr, Quebec. Credit: Wesdome Gold Mines.

Wesdome Gold Mines (TSX: WDO) operates the Eagle River complex nearby Wawa in Ontario and also holds the Kiena project in Quebec.

This year, its guidance is for 90,000 oz. to 100,000 oz. of gold at all-in sustaining costs of US$985 to US$1,049 per ounce.

The majority of this production is expected to come from the Eagle River underground mine with a minor contribution from the Mishi open pit at the Eagle River complex.

The Eagle River underground operation and Mishi pit feed a central 850 tonne per day mill at Eagle River with additional exploration underway to extend existing zones of mineralization and identify new lenses.

In February, the company announced exploration results from the Ontario asset, with drilling extending the Falcon zone as well as the 303 Lens. The latter is a potential source of short to medium-term mill feed. Intercepts of note included 3 metres of 49.4 grams gold per tonne from Falcon as well as 6.4 metres of 49.1 grams gold from the 303 Lens.

The Kiena complex in Val dOr has been on care and maintenance since 2013 and contains a permitted, 2,000 tonne per day mill, a 930 metre shaft, and a ramp system that extends to 1,050 metres depth. Total measured and indicated resources at the property are at 2.8 million tonnes grading 8.67 grams gold for a total of 788,100 oz. with further inferred resources of 2.9 million tonnes at 8.51 grams gold for 798,100 oz.; approximately half of these resources are contained within the higher-grade Kiena Deep A zone.

This year, the companys $19.8-million exploration budget is allocated towards 85,000 metres of drilling at Kiena and a total of 152,500 metres at Eagle River.

A preliminary economic assessment is underway evaluating a restart of Kiena, which is expected in the second quarter. In February, Wesdome also released drill results from this project, which extended the Deep A zone down plunge. Highlights from step out work included 10 metres of 114.8 grams gold and 17.2 metres of 25.3 grams gold.

The company also holds the Moss Lake property, covering 36 km of strike along the Shebandowan greenstone belt, 100 km west of Thunder Bay in Ontario. The property hosts measured and indicated resources of 1.4 million oz., with additional inferred resources of 1.8 million ounces. Current resources grade 1.1 grams gold.

Wesdome has a $852.8-million market capitalization.

Yamana Gold

Pit activity at Agnico Eagle Mines and Yamana Golds Canadian Malartic gold mine in Quebec. Credit: Yamana Gold.

Yamana Gold (TSX: YRI; NYSE: AUY) is a gold and silver producer with operations in Canada and South America. This year it expects to generate 990,000 gold-equivalent oz. on a company-wide basis.

The companys largest gold contributor is the Canadian Malartic open-pit mine in Quebec, which is expected to churn out 330,000 oz. of gold this year for Yamana at all-in sustaining costs of US$820 to US$850 per gold-equivalent ounce. Yamana has a 50% stake in the asset with Agnico Eagle Mines (TSX, NYSE: AEM ) also at a 50% ownership. The two companies operate the mine through a partnership. Exploration is also underway at this asset to evaluate additional deposits and prospective areas.

In Chile, Yamana owns the El Penon gold-silver underground mine, which is expected to contribute 162,000 oz. of gold and 4 million oz. of silver in 2020 at AISCs of US$930 to US$960 per gold-equivalent ounce. Earlier this year, the company was able to increase its gold and silver reserves for the asset, net of mining depletion, and also up its gold measured and indicated resources by 66%.

The companys Jacobina complex of underground mines in Brazil is forecast to generate a further 162,000 oz. of gold this year at AISCs of US$860 to US$890 per oz. A two-phase expansion is underway for this project, with the first phase increasing output to the 170,000 oz. per year range and the second, pending approval, potentially ramping the asset up to the 225,000 oz. per year rate. A pre-feasibility study is underway to assess optimal expansion scenarios.

In Argentina, Yamanas Cerro Moro complex is forecast to produce 117,000 gold oz. this year with a further 7.5 million oz. of silver at AISCs of US$970 to US$1,000 per oz. The Minera Florida underground mine in Chile is anticipated to generate 86,000 oz. of gold in 2020 at AISCs of US$1,130 to US$1,160 per oz.

In addition to its producing mineral assets, Yamana holds the Agua Rica copper-gold-silver-molybdenum deposit in Argentina with a feasibility study expected by the end of this year. The company is evaluating strategic options and partnerships to maximize the value from this asset.

Yamana also holds an 8.75% stake in Equinox Gold (TSX: EQX; NYSE: EQX), a company with six producing gold mines, and in, February, the company sold its royalty portfolio to Nomad Royalty (TSXV: GV) for a total of US$65 million.

In March, the company announced a partial temporary demobilization of its workforce at Cerro Moro in Argentina due to the COVID-19 virus. As of presstime, the company was not expecting this ramp-down to have a meaningful impact on its production guidance for the year.

Yamana Gold has a $3.6-billion market capitalization.

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Global Gold Snapshot: Eight companies to watch - The Northern Miner

Recommendation and review posted by Bethany Smith

Oxford academic claims future humans could live for thousands of years – Express.co.uk

The comment was made by Anders Sandberg, a senior research fellow at the universitys Future of Humanity Institute. His work focuses on the potential risks future technology could pose to human civilisation.

Mr Sandberg has also spent decades involved with the transhumanist movement, which consists of people who believe humans can and should use technology to artificially augment their capabilities.

Speaking to Express.co.uk he argued humans in the future could enjoy greatly expanded lifespans and could even have their brains uploaded onto computers for safekeeping.

Asked how long humans could live Mr Sandberg replied: There is no fundamental ceiling but you are going to need to solve certain problems.

Accidents is the first one cryonics wont help you if a bus runs over you and turns you into mush.

Even if ageing and disease is not a problem you need to handle accidents and probably that means having some form of backup copies. You need some form of uploading or artificial body.

Probably the human brain cant handle that much information so you need to extend it as you get older.

You want to remember what needs to be remembered and maybe put other stuff in cyber storage.

Transhumanists believe humans can halt the ageing process and natural death.

According to Mr Sandberg this is one of the most provocative aspects of their programme.

He explained: Transhumanists have essentially since day one been saying we should really extend the human lifespan and this is perhaps one of the most controversial claims ever made.

We get way more pushback when talking about life extension than cloning or uploading into computers or going to space or taking drugs to become a more moral person.

Thats nothing compared to the potential of oh you might live much longer than you expected.

READ MORE:Academic explains how humans could become part mechanic cyborgs'

That is kind of dreadful to many people so they get very upset and start defending disease, sickness and death very strongly.

Its weird because if one believed their arguments we should be shutting down hospitals left and right and having people naturally and painfully die which of course people dont normally do. Normally we are very keen on having good hospitals and ambulances.

Mr Sandberg is the co-founder of Swedish thinktank Eudoxa and previously chaired the Swedish Transhumanist Association.

Transhumanist ideas have been gaining ground over recent years, with transhumanist political parties emerging in countries across the world including the UK.

An American transhumanist, Zoltan Istvan, recently ran against Trump for the 2020 Republican Presidential nomination.

Mr Sandberg also suggested advances in AI and drugs that improve human abilities are likely to play a role in the future.

READ MORE:US Presidential hopeful plans to ABOLISH DEATH using technology

He asserted: Its very likely artificial intelligence is going to become extremely powerful relatively soon.

Not necessarily the kind of self-willed Hal like being but at least very smart services that can solve problems for us which might speed things up.

I also have been working quite a lot on the ethics of cognitive enhancement. What about making ourselves smarter?

The good news is there are various things like smart drugs that might be helpful for certain mental tasks.

The bad news is there doesnt seem to be anything that really boost intelligence itself. That seems to be very complicated and we dont understand the brain well enough.

Oxford Universitys Future of Humanity Institute was founded in 2005 to focus on the opportunities and threats that could emerge for the human species.

It is headed by Swedish philosopher Nick Bostrom, who grabbed wide attention with his 2014 book Superintelligence: Paths, Dangers, Strategies.

Asked what the world could look like in 40 years time Mr Sandberg replied: think a time traveller going 40 years into the future is first going to be super disappointed because it looks almost the same.

On the surface I think its going to be very similar theres going to be vehicles moving around, maybe without any drivers, there are going to be houses around and so on and then they start interacting with people and theyre going to realise this society works completely differently.

We most likely are going to have quite a lot of enhancements around that are regarded as everyday.

People are not going to think that the morning cognition enhancing pill is any weirder than the morning coffee they might even be the same thing.

The existence of a lot of machine learning and probably nanotechnology making a lot of material way more alive than they used to.

Link:
Oxford academic claims future humans could live for thousands of years - Express.co.uk

Recommendation and review posted by Bethany Smith

Coronavirus ‘cures’ and prevention techniques are popping up all over the world. So we asked the experts what actually works – ABC News

Updated March 23, 2020 19:48:55

With the whole world talking, reading, posting and sharing all sorts of information about coronavirus, it can be hard to sort through what is actually a fact and what is a myth.

Maybe you've got a friend writing on Facebook about how coronavirus will die with a change of season, or another who thinks they've got an excellent home remedy to prevent themselves from getting the disease?

Whatever the case, there are some myths that keep popping up over and over again. So, we've gone to the experts.

Here's what our correspondents say are some of the most popular myths around, and two experts' takes on them.

Who is saying this? The President of the United States.

What's being said exactly? Donald Trump told Fox Business: "You know in April, supposedly, it dies with the hotter weather."

According to CNN, he also told state governors: "You know, a lot of people think that goes away in April with the heat as the heat comes in. Typically, that will go away in April."

How widespread is this? Well, Donald Trump's quotes have been reported by major news outlets.

Professor of respiratory diseases at the University of Technology Sydney Brian Oliver says it would depend on the temperature you're talking about.

"For example, your body temperature is 37 degrees Celsius and we know coronavirus can survive in that, so if it's 37C or 40C outside, it would probably survive," Professor Oliver said.

"If it were something like 50C, well then it probably wouldn't survive too well. But how many places reach 50C?"

Infectious disease experts have also told CNN that it's too early to say whether warmer weather could impact the virus, and "nobody knows enough about the novel coronavirus to make assessments about its behaviour".

However, Professor Oliver said extreme heat can be useful.

"Extreme heat is used as a form of sterilisation in hospitals," he said.

"And if it's a really sunny day, the UV rays contained in the sun could kill the virus as well. Basically, the UV light destroys the genetic material. But we don't know how long is needed to kill the virus.

"So heat can be useful, but a warm day and 37C would be regarded as a warm day is not going to do much."

As told by South-East Asia correspondent Amy Bainbridge and Indonesia correspondent Anne Barker

Who is saying this? Residents in Bangkok, Indonesians and even Indonesian President Joko Widodo.

What exactly are they doing? There is a clinic outside Bangkok that doubles as a medicinal cannabis clinic. It looks like they're being run off their feet producing pills that contain a special herb called Andrographis Paniculata.

It's traditionally believed to be a treatment for colds and sore throats and apparently people are lining up to use it.

Meanwhile, in Indonesia, herbs have also become popular with residents looking to ward off coronavirus. Indonesians have rushed to buy herbal and medicinal plants such as turmeric, curcumin, lemongrass and ginger.

They believe that 'jamu' medicinal drinks made with such ingredients can boost stamina and health, and help strengthen the immune system.

Mr Widodo even last week told an agricultural and food conference that he drinks the herbal elixir three times a day to help prevent infection by coronavirus.

"I drink the mixture instead of tea now," he said.

"I give the drinks to my guests, be it the morning, afternoon or evening."

How widespread is this? Jamu is popular across Indonesia, although its ingredients might differ from one province to another.

The demand for ginger and turmeric has soared in the capital Jakarta and much of Java, where the price of red ginger has almost doubled in some places, and turmeric has tripled.

University of Melbourne professor of virology Damian Purcell says we haven't seen any scientific validation of those kinds of things.

"It's a risky strategy to believe something works without proper clinical trials and as yet there are no trials focused on examining whether specific herbs would be effective."

As told by South Asia correspondent James Oaten

Who is saying this? Fringe Hindu groups and a politician.

What exactly are they doing? Dozens of Hindu activists gathered in New Delhi on the weekend to hold a cow-urine drinking party, believing the drink would ward off coronavirus (and many other illnesses).

Others have also touted the health benefits of cow urine and even cow dung, including recently a politician from the Prime Minister's own party in the north-eastern region of Assam.

Many Hindus regard the cow as sacred.

Is this a common belief? It's mostly being touted by fringe groups so is far from being a popular myth.

Professor Oliver says it would "not do anything good for you".

While he says urine would have some slightly disinfectant properties on surfaces, "you'd have to drown someone in urine to save them from coronavirus".

"The only thing it could partially be useful for is, if you didn't have access to soap and water, you could use it to partially disinfect surfaces," he said.

As told by Middle East correspondent Eric Tlozek

Who is saying this? People in Iran.

What's being said exactly? Some believe drinking alcohol can be a way of killing coronavirus, according to Iranian sources I've spoken to.

One contact told me: "You know how alcohol is prohibited in Iran so, one of the good businesses here is some people make alcoholic drinks at home and they sell it [at a high price]."

Is it a common belief? It doesn't appear to be too common at this stage.

That's unlikely, Professor Oliver says. He points out that "you'd need a high concentration of alcohol to kill a virus".

"In the handwash you use for example, you need 60-70 per cent ethanol to be effective," he said.

"If people are drinking spirits, the relative concentration of that is relatively low. So the amount you would need to drink would kill you before it kills the virus."

Professor Purcell agrees, adding "very few spirits have above 30 to 40 per cent which would not be enough to kill the virus".

As told by Papua New Guinea correspondent Natalie Whiting

Who is saying this? It appears to have started in the United States but is also being spread on social media in PNG.

What exactly are they saying? The most common myth that has been raised with me, and one I've seen shared widely on social media, is that black people can't get coronavirus.

When the virus first started making headlines, I was asked about this rumoured immunity by a few people in PNG. Some posts on social media here were claiming there was a link between the virus and melanin levels.

How widespread is this? Now that the virus has spread further and there have been cases recorded in the Pacific, there have been more people trying to debunk this myth on social media.

"That's crackers."

According to Professor Oliver, the theory makes "absolutely no sense".

"Whatever pigmentation you have is of no interest to the virus because it doesn't impact the skin," he said.

"It would perhaps play a role if the virus infected the skin. But in this case, it doesn't so I'm not sure where people are getting this idea from."

Professor Purcell says: "The virus doesn't replicate in skin."

"It targets cells where there is no melanin, in the lungs and gastrointestinal tract, and there are no difference in melanin levels in those tissues," he said.

"Nobody is immune."

As told by Indonesia correspondent Anne Barker

Who is saying this? Social media users in Indonesia.

What are they saying? Posts on social media in the past few weeks have claimed coronavirus does not attack people who smoke because the composition of tobacco and cloves can resist the attack.

One Facebook user said cigarette smoke is effective in killing the virus.

How widespread is this? The original claim has gone viral on Twitter and other social media. That's despite there also being many health messages warning of the dangers of smoking.

The claims have been denied by health experts, including Eijkman Institute for Biology and Higher Education molecular biologist Professor Amin Soebandrio.

He says smoking increases ACE 2 receptors in the lungs that cause the COVID-19 virus.

Professor Soebandrio says each receptor acts like a port, so if there are more berths, more "ships" will come.

Professor Oliver agrees, saying if anything "smoking makes the outcomes worse".

Who is saying this? The internet. Social media. Your neighbours/friends/family?

What exactly are they saying? According to Johns Hopkins Medicine, there have been a couple of myths around swallowing or gargling essential oils, salt water and other home remedies as a way to cure coronavirus.

How widespread is this? It appears to be a common enough query to prompt Johns Hopkins to respond to it on their website.

Once you're infected there is very little chance these would work, Professor Purcell says.

"The virus introduces genetic material into your body, so you have to get rid of the cell itself," he said.

"While some of these things [antibacterial mouth washes] can kill a virus on a sheet of stainless steel, once it's in your system, you might reduce the amount of virus that you're shedding, but you need your immune system to do the job."

Professor Oliver agrees, although he suggests that traditional medicines do "have some efficacy around various conditions".

"But even when they work, they don't work as well as Western medicines," he said.

"Even if they are successful one day, like with herbal teas and so on, part of the problem is that it's really hard to know whether that effect could be replicated on the next day.

"Whereas a drug designed in a lab is made to be the same each time, and you also know something of the safety measures used to make the drug."

Professor Purcell says one reason that you might see these myths pop up is because it's difficult to understand the science behind viruses, so people begin to introduce their own ideas.

"You can't see it, so you can't relate to the chemistry," he said.

Professor Oliver agrees, adding that some of these cures or prevention techniques are the equivalent of old wives' tales.

Or, sometimes, they can stem from cultural beliefs that are passed down.

Topics:respiratory-diseases,infectious-diseases-other,diseases-and-disorders,health,world-politics,government-and-politics,china,indonesia,united-states,thailand,iran-islamic-republic-of

First posted March 23, 2020 17:41:27

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Coronavirus 'cures' and prevention techniques are popping up all over the world. So we asked the experts what actually works - ABC News

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How Skin Cells Prepare To Heal Wounds – Technology Networks

A team of University of California, Irvine researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds. Results from the study provide a blueprint for future investigation into pathological conditions associated with poor wound healing, such as in diabetic patients.

"This study is the first comprehensive dissection of the major changes in cellular heterogeneity from a normal state to wound healing in skin," said Xing Dai, PhD, a professor of biological chemistry and dermatology in the UCI School of Medicine, and senior author. "This work also showcases the collaborative efforts between biologists, mathematician and physicists at UCI, with support from the National Institute of Arthritis & Musculoskeletal & Skin Diseases-funded UCI Skin Biology Resource-based Center and the NSF-Simons Center for Multiscale Cell Fate Research.

The study, titled, "Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics," was published this week in Cell Reports.

"Our research uncovered at least four distinct transcriptional states in the epidermal basal layer as part of a 'hierarchical-lineage' model of the epidermal homeostasis, or stable state of the skin, clarifying a long-term debate in the skin stem cell field," said Dai.

Using single-cell RNA sequencing coupled with RNAScope and fluorescence lifetime imaging, the team identified three non-proliferative and one proliferative basal cell state in homeostatic skin that differ in metabolic preference and become spatially partitioned during wound re-epithelialization, which is the process by which the skin and mucous membranes replace superficial epithelial cells damaged or lost in a wound.

Epithelial tissue maintenance is driven by resident stem cells, the proliferation and differentiation dynamics of which need to be tailored to the tissue's homeostatic and regenerative needs. However, our understanding of tissue-specific cellular dynamics in vivo at single-cell and tissue scales is often very limited.

"Our study lays a foundation for future investigation into the adult epidermis, specifically how the skin is maintained and how it can robustly regenerate itself upon injury," said Dai.

Reference:Haensel, D., Jin, S., Sun, P., Cinco, R., Dragan, M., Nguyen, Q., Dai, X. (2020). Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics. Cell Reports, 30(11), 3932-3947.e6. https://doi.org/10.1016/j.celrep.2020.02.091

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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An unusual chance to see stress at work – Big Think

It's not your imagination, it turns out. Stress can turn a person's hair gray. It's said that if you look at before and after pictures of any eight-year U.S. president the impact of the office on hair color is clear, though in fairness, it may be that candidates dye their hair and then at some point stop doing so. Nonetheless, scientists from Harvard have not only verified the conventional wisdom on our graying noggins, but have also figured out why stress is so brutal to our follicular pigmentation.

The new research from Harvard scientists is published in the journal Nature.

Image source: Ververidis Vasilis/Evan El-Amin/Vacclav/Shutterstock/Big Think

Senior author of the study Ya-Chieh Hsu, professor of Stem Cell and Regenerative Biology at Harvard, explains what prompted her research:

"Everyone has an anecdote to share about how stress affects their body, particularly in their skin and hair the only tissues we can see from the outside. We wanted to understand if this connection is true, and if so, how stress leads to changes in diverse tissues. Hair pigmentation is such an accessible and tractable system to start with and besides, we were genuinely curious to see if stress indeed leads to hair graying."

It turns out that stress activates nerves associated with our basic fight-or-flight system, and these nerves permanently damage pigment-regenerating melanocyte stem cells in hair follicles, causing them to cease production of melanin that normal provides color to hair follicles.

Hsu's team studied the issue using mice, and was somewhat stunned at their findings. "When we started to study this, I expected that stress was bad for the body but the detrimental impact of stress that we discovered was beyond what I imagined," recalls Hsu.

The scientists stressed the mice using a combination of three methods:

Image source: Helga Lei/Shutterstock

Hsu and her colleagues first suspected an immune system reaction was at the root of graying hairs only to discover that mice without immune systems still turned gray in response to stressors. The next suspect was cortisol produced by the adrenal glands however, this proved not to be so. "Stress always elevates levels of the hormone cortisol in the body," says Jsu, "so we thought that cortisol might play a role. But surprisingly, when we removed the adrenal gland from the mice so that they couldn't produce cortisol-like hormones, their hair still turned gray under stress."

Image source: Judy Blomquist/Harvard University

Finally, the researchers investigate the possibility that the system responding to stressors was the mice's sympathetic nervous systems, the part of the nervous system that kicks into action with the fight-or-flight impulse. The sympathetic nervous system is a vast network of nerves that connects, among other places, to hair follicles in the skin. In response to stress, the system sends a rush of the chemical norepinephrine to the follicles' melanocyte stem cell, causing them to quickly burn through and deplete their stores of pigment.

Say Hsu, "After just a few days, all of the pigment-regenerating stem cells were lost. Once they're gone, you can't regenerate pigments anymore. The damage is permanent." Great for survival, not so good for hair color.

Sympathetic system nerves are magenta above. Melanocyte stem cells are yellow.

Image source: Hsu Laboratory, Harvard University

"Acute stress," says lead author of the study Bing Zhang, "particularly the fight-or-flight response, has been traditionally viewed to be beneficial for an animal's survival. But in this case, acute stress causes permanent depletion of stem cells."

The research, done in collaboration with other Harvard researchers, presents a new appreciation of the effect the sympathetic system can have on the body's cells during stress.

One of these collaborators, Harvard immunologist Isaac Chu, notes, "We know that peripheral neurons powerfully regulate organ function, blood vessels, and immunity, but less is known about how they regulate stem cells. With this study, we now know that neurons can control stem cells and their function, and can explain how they interact at the cellular and molecular levels to link stress with hair graying."

Given this finding regarding the direct impact of stress on follicular stem cells, the question of what it else it may affect becomes an obvious one. As Hsu sums it up, "By understanding precisely how stress affects stem cells that regenerate pigment, we've laid the groundwork for understanding how stress affects other tissues and organs in the body."

This importance of the study therefore goes way beyond graying heads. "Understanding how our tissues change under stress is the first critical step," says Hsu, "toward eventual treatment that can halt or revert the detrimental impact of stress. We still have a lot to learn in this area."

Related Articles Around the Web

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The bacteria-trapping protein that may provide a new target for tracking and treating breast cancer – FierceBiotech

Scientists at the Pennsylvania State University and Henan University in China have found a new protein marker that they say could potentially predict the progression of breast cancer or be targeted by drugs designed to treat the disease.

The protein, called PAD4, is key in the immune response against bacteria. The researchers found that its expression in cancer cells can also promote breast cancer metastasis in mice, according to a new study published in the journal Molecular Cancer Research.

PAD4 exists in abundance in neutrophils, a type of white blood cells. It mediates the formation of a loosened DNA and protein structure outside the cell called neutrophil extracellular traps (NETs). Normally, NETs trap and help kill bacteria. Recent studies have also found that NETs play a part in promoting cancer metastasis. But little was known about whether PAD4 can trigger a similar process in breast cancer cells.

That was what the Penn State and Henan team set out to study. We were interested in learning if PAD4 expression in breast cancer cells could affect cancer biology, such as tumor growth and metastasis, Yanming Wang, the studys senior author, said in a statement.

So the team profiled gene expression in breast cancer cells from the Cancer Genome Atlas and Oncomine database. They found human breast cancer cells have higher PAD4 expression than do normal cells. In a triple-negative breast cancer cell line called 4T1, the researchers also observed even bigger PAD4 levels than what existed in other cell lines.

RELATED:Preventing breast cancer metastasis by killing tumor cells in their sleep

Additional analysis showed that the activation of PAD4 in 4T1 cells also led to the release of chromatin fibers outside to form NET-like structures. The researchers called them cancer extracellular chromatin networks (CECNs).

CECN formation is dependent on PAD4, the team found, as treating the 4T1 cells with a pan-PAD inhibitor or knocking it out prevented the release of CECNs.

Wang and colleagues further assessed the role of PAD4 on tumor growth and metastasis. In mice injected with 4T1 breast tumors, those bearing the PAD4 marker saw significantly faster tumor growth and had much more metastases in the lungs than did animals without the marker.

To further test the idea that CECNs are indeed involved in metastasis, the researchers disrupted extracellular DNA including CECN in PAD4-knockout mice that were unable to release additional CECN. Although the procedure didnt change the primary tumor, lung metastasis was significantly decreased, the team reported. Further investigation showed that PAD4 promoted tumor growth after cancer cells had reached the lungs.

RELATED:CRISPR slows the growth of triple-negative breast cancer in mice

Despite the availability of many therapies, breast cancer is still the second leading cause of cancer-related deaths in women in the U.S. Many research groups are looking for new ways to block metastasis, which is a major cause of death.

Scientists at the Institute of Cancer Research recentlyfound that blocking a protein kinase called MPS1 caused triple-negative breast cancer cells to divide so fast that they accumulated fatal errors. Researchers at the Fed Hutchinson Cancer Research Center showed that inhibiting proteins called integrins could target dormant estrogen receptor-positive breast cancer cells to prevent metastasis. And last year, a team at Boston Childrens Hospital used nanoparticles targeting the ICAM-1 molecule on triple-negative breast cancer cells to deliver a CRISPR system, which edited out a gene called Lipocalin 2 to slow tumor growth.

Wang believes PAD4 may offer a novel approach to tacklingbreast cancer. While further investigation is needed, it is interesting to consider the possibility that PAD4 or CECNs could potentially be used as biomarkers to predict disease progression, he explained. Furthermore, therapies to inhibit PAD4 or eliminate CECNs could be explored as a method to reduce the risk of metastasis in patients with breast cancer.

The team is now investigating the exact mechanism by which PAD4 affects CECN formation and drives tumor growth. The researchers are also studying additional cell types to better understand the prevalence of CECN formation and PAD4s role.

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Eric Gopel, MD, on Growth Hormone Therapy in Patients With IGF1R Mutation – MedPage Today

While patients who are born small for their gestational age (SGA) have shown improvement with recombinant human growth hormone (rhGH) therapy, not much research has been conducted on patients who have the IGF1R mutation.

That's why Eric Gpel, MD, and colleagues conducted a study of these patients, which has been published in the Journal of Clinical Endocrinology & Metabolism. They found that while IGF1R carriers did show a lower growth response, they did catch up with other SGA patients.

Dr. Gpel answered some of MedPage Today's questions about their research on hormone therapy for these patients.

Why did you decide to study growth hormone (GH) therapy response in IGF1R patients?

Gpel: Although IGF1R mutations were first described in SGA patients more than 15 years ago, studies examining patient characteristics and treatment options in a cohort are very rare. Most probably IGF1R patients have been treated with the diagnosis "small for gestational age without catch-up growth" for a long time, without knowing the molecular diagnosis, and while case descriptions provided first hints on therapeutic success, cohort analyses were lacking.

You found that IGF1R mutation carriers showed a more pronounced growth retardation and lower response to rhGH therapy than others and that IGF1R mutation good responders showed catch-up growth to the levels of SGA patients. Were these results surprising to you?

Gpel: The clinical experience of our pediatric endocrinologists and various case reports gave the impression of a poorer therapeutic outcome compared to SGA patients. In addition, a lower response to GH could be expected due to the fact that the (aberrant) IGF1 receptor is at the lower end of the growth hormone axis. However, we were surprised by the high variability among patients; the more as we could not find any significant correlation with the kind of mutation. However, growth is a multifactorial process and other, genetic or non-genetic factors, can be expected to modify the response to GH.

What would you say to a physician who finds these results discouraging when it comes to treating patients with the IGF1R mutation?

Gpel: The decision in favor of a GH therapy should, of course, not be taken lightly. However, our study showed that -- despite a somewhat poorer average response -- some patients in the group of IGF1R mutation carriers clearly can benefit from GH therapy. Currently, it is simply not predictable how well or poorly a specific patient will respond to GH therapy. For this reason, we recommend favoring a treatment, re-evaluating the success of therapy periodically, and considering discontinuation of treatment in case of a poor response.

What would you like to see happen as a result of your study? More research? Clinical practice changes?

Gpel: IGF1R deficiency is a relatively rare finding and our study cohort is comparably small. Therefore, further studies are needed to identify factors that make GH treatment success in individual patients more predictable. This will make therapy decisions easier for pediatricians and parents. A distant aim would be to provide an estimation of therapy success according to the patients' individual mutation based on large cohort studies.

You concluded that IGF1R mutation should not be excluded from rhGH treatment, but that a critical re-evaluation of success should be performed periodically. How often do you recommend re-evaluation? What are some key things clinicians should be looking for when they re-evaluate?

Gpel: We would suggest regular control intervals of about half a year with special attention to changes of growth rate. The increment of height velocity SDS values within the first year of treatment could provide initial information about responsiveness. Of course, other aspects such as therapy adherence, socio-psychological aspects, and potential side effects have to be taken into account since GH therapy is a long-lasting treatment.

Is there anything else physicians should know about IGF-1 serum levels?

Gpel: We think that therapy monitoring by IGF-1 serum levels is one of the most difficult aspects in the treatment of SGA patients with IGF1R defects. They tend to have elevated IGF-1 levels, especially under treatment with GH. Because we do not have long-time outcome data, it is difficult to advise which is the upper acceptable limit in a patient with IGF-1 resistance under GH treatment that is both safe and that provides the best therapeutic outcome. Therefore, we recommend following these patients closely and collecting data carefully.

You can read expert commentary about the clinical implications of this study here and review the abstract here.

Last Updated March 17, 2020

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Dr. Gaines Provides Insight Into How People Can Best Protect Themselves and Their Families From the COVID-19 Virus – Yahoo Finance

Dr. Gaines of Life Gaines Medical & Aesthetics Center sends out info about the COVID-19 virus for concerned patients and the general public in South Florida

Boca Raton, Florida--(Newsfile Corp. - March 20, 2020) - LifeGaines reaches out to its patients and community who are concerned about COVID-19, the novel coronavirus.

"Dear LifeGaines Medical & Aesthetics Family,

"The staff at LifeGaines takes your health and safety seriously and we won't compromise when it comes to protecting our patients. We are closely monitoring the World Health Organization and CDC with regard to ongoing developments of the coronavirus (COVID-19) and we are committed to providing you a safe and clean environment.

"In an effort to reassure our patients, we want to inform you that we are continuing our rigorous routines to keep our practice sanitized and clean and will continue to take every precaution to keep you safe. Our daily safety standards include disinfecting our treatment rooms and equipment after each treatment and thoroughly washing our hands. We also wear new, clean gloves when applying products to our patients' skin and discard after each use. Also, our office is cleaned daily including wiping down tabletops, doorknobs, and equipment using medical-grade disinfectants."

Dr. LifeGaines reaches out to patients and community in light of COVID-19

To view an enhanced version of this graphic, please visit:https://media.zenfs.com/en-us/newsfile_64/2f7e8700c7c06672c2bf9192647742d9

Please don't hesitate to contact us with any questions or concerns at (561) 931-2430. We look forward to seeing you soon.

https://www.facebook.com/LifeGaines/posts/1067452740282001 - Dr. Gaines gives a message on Facebook about how he is boosting his immune system as the COVID-19 virus spreads across the U.S.

Dr. Gaines talks about the benefits of IV ozone therapy. In addition to immunotherapy which helps boost someone's immune system, one should also drink plenty of water and get enough rest.

Story continues

LifeGaines is mobile and visiting patients at their homes with the IV ozone therapy treatment. Inquire about this by calling LifeGaines.Learn about IV Vitamin Therapy here: https://lifegaines.com/wellness-therapies/iv-vitamin-therapy/

Don't hesitate to contact LifeGaines with any questions or concerns at (561) 931-2430.

About Dr. Gaines' LifeGaines team:

LifeGaines is one of the most highly respected age management medical teams anywhere. Age management medicine pioneer Dr. Richard Gaines has years of experience specializing in hormone replacement therapy, sexual wellness, platelet-rich plasma, stem cells, aesthetics, and advanced age management protocols.

About Dr. Gaines:

Dr. Richard Gaines graduated from Boston University School of Medicine in 1981. He completed his internship at Tufts University School of Medicine in 1981 and his residency at Harvard Medical School in 1985, where he was an anesthesiology fellow at Brigham and Women's Hospital. He served as a physician at Huntington General Hospital, as an anesthesiologist at Harvard Community Health Plan and at Sheridan Healthcorp. Dr. Gaines opened an age management and wellness practice after a 40-year career as a physician and health care executive. He has a Fellowship in Anti-Aging and Regenerative Medicine (FAARM) from the American Academy of Anti-Aging Medicine, he's board-certified from the American Board of Anti-Aging & Regenerative Medicine (ABAARM) and he's certified as a Functional Medicine Practitioner with advanced training at The Institute for Functional Medicine.

LifeGaines is responsible for this press release.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/53638

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Identify the root of your symptoms using functional blood tests at RedRiver Health and Wellness – St George News

Stock image, St. George News

CONTRIBUTED CONTENT Have you seen your doctor because you suffer from fatigue, brain fog, hair loss, digestive issues, joint pain, or other symptoms, and you were told your blood test is normal? You may have even been given a prescription for antidepressants, because your tests dont seem to indicate you have a physical health problem.

You know something is wrong and that youre not supposed to feel this way, but what is the cause? At RedRiver Health and Wellness Center, we believe the reason your blood test didnt show anything wrong with you is because most doctors use lab ranges instead of functional ranges when evaluating the results.

A lab range identifies acute disorders and diseases, while a functional range uses parameters of optimal health and identifies problems that often can still be reversed. This allows you to do something about the problem before its too late.

For instance, using a functional range, you can identify hypothyroidism even though your primary thyroid marker is normal according to a lab range.

Address your health problem before its too late

In functional medicine, we identify and manage the root cause of symptoms instead of using drugs or surgery to stamp them out although medications or surgery may still be necessary in some cases. The most common analogy we use in functional medicine is that when the check engine light comes on, we look under the hood to diagnose the problem instead of turning off the engine light.

Functional blood test ranges, which outline the parameters of good health, are an important tool to help us with this.

What is the difference between functional ranges and lab ranges on a blood test?

For the most part, lab ranges are based on a bell-curve analysis of the people who had blood drawn at that lab over a certain period of time. Naturally, many of these people are getting their blood drawn because they have a health problem.As a result, lab ranges have broadened over the last 20-30 years as the health of the United States population has declined.

This means many people with health issues may be told nothing is wrong because their labs fit in with most people at that lab. If you want to evaluate your health in terms of what is optimal, then functional ranges are the way to go.

Looking for patterns on a functional blood test

With a functional blood test, we also look at patterns of markers instead of looking at each marker in isolation. This is based on understanding that various aspects of human physiology are interrelated and affect one another. Doing this allows us to see how different systems influence one another to cause a pattern of symptoms.

For instance, evaluating immune cells more broadly can give us clues as to whether inflammation is chronic or acute and whether it is caused by a virus, bacteria, allergies or parasites. Other patterns can help us spot fatty liver, leaky gut, different types of anemia or autoimmune disorders. This then helps us determine what types of testing are further needed.

Functional blood tests are more thorough

Functional medicine blood tests are also more comprehensive than a standard blood test.For example, a basic thyroid test from your doctor probably only looks at TSH, or thyroidstimulating hormone. However, because autoimmune Hashimotos, which attacks and destroys the thyroid gland, causes 90% of hypothyroid cases in the United States, we run autoimmunemarkers to screen for Hashimotos. We also look at other markers to see whether additional factors are contributing to your low thyroid symptoms.

Ask my office for more information regarding a functional blood test if you are struggling withchronic health symptoms that are sabotaging your quality of life.

Written by JOSH REDD, chiropractic physician atRedRiver Health and Wellness Center.

S P O N S O R E D C O N T E N T

About Dr. Josh Redd

Josh Redd, MS, DABFM, DAAIM, is a chiropractic physician and author of the Amazon bestselling book The Truth About Low Thyroid. Redd owns seven functional medicine clinics in the western United States and sees patients from across the country and around the world who are suffering from challenging autoimmune, endocrine and neurological disorders. He also teaches thousands of health care practitioners about functional medicine and immunology, thyroid health, neurology, lab testing and more.

Resources

Email: news@stgnews.com

Twitter: @STGnews

Sponsored content may be submitted to or developed by St. George News for publication on behalf of the sponsor and in the sponsor's interest. It may include promotional pieces, features, announcements, news releases and advertisements. Opinions expressed in sponsored content are those of the sponsor and not representative of St. George News. Sponsors have no influence over St. George News reporting and product apart from their own sponsored content.

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Use these items to appropriate hormone imbalance – Sahiwal Tv

Imbalance of hormones causes many issues. When any hormone current within the physique turns into kind of than the prescribed restrict, then illnesses begin to happen. It is essential for ladies and men to stay wholesome that the steadiness of hormones within the physique is maintained. Hormones have an effect on not solely the physique but additionally the mind and feelings.

AIIMS physician Anurag Shahi, related to http://www.myupchar.com, says that hormones are the chemical parts of the physique, which make many glands within the physique. These highly effective chemical compounds are unfold all through the physique together with blood and helps the tissues and inside organs of their work. When the steadiness of hormones turns into ineffective, a selected hormone both decreases or turns into an excessive amount of.

->This situation is named hormone imbalance or hormone imbalance.

Specific meals may help steadiness hormones. There is a risk of enchancment in total well being with out taking any drugs. Although everybody's physique reacts otherwise, these wholesome meals are possible to make sure a nutritious diet that helps the physique operate higher.

Flaxseed seedsLinseed seeds can have all types of advantages for hormones. Linseed seed is a superb supply of 'phytoestrogens' and it particularly incorporates a sort of phytoestrogen, which is named lignan. Lignans have each estrogenic and antiestrogenic results, and are identified to have protecting advantages towards particular kinds of most cancers. Linseed seeds are additionally a very good supply of omega-Three fatty acids, fiber and antioxidants.

The nutsNuts like almonds have an effect on the endocrine system, which can assist cut back levels of cholesterol. They may assist decrease insulin and steadiness blood sugar ranges.

Walnuts specifically include polyphenols, which might defend the guts by combating free radicals within the physique. This ingredient may include anti-inflammatory brokers and is wealthy in omega-3s, that are wonderful for mind well being.

PomegranateThis antioxidant-rich fruit could assist in blocking estrogen manufacturing within the physique. Pomegranate has the power to stop the kinds of breast most cancers that react to estrogen. Pomegranate incorporates a pure agent that may inhibit an enzyme within the physique of girls that converts estrone into estradiol. It is a robust estrogen that may play a task within the origin of hormonal most cancers.

turmericTurmeric is at all times often known as a very good methodology for the remedy of irritation, as its made from curcumin. Many therapeutic properties are present in turmeric. This conventional Indian spice has the power to scale back ache throughout arthritis. Curcumin, the lively ingredient of turmeric, can simulate estrogen exercise. This herb may help cut back the ache of durations.

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Polygamy, abortion, affordable housing: What passed during Utah’s legislative session – Daily Herald

The Utah State Legislature passed 510 bills over this years 45-day general session, ranging from a bill to fund affordable housing projects to a law regulating the disposal of fetal remains.

While this is lower than the number of bills passed during last years session, 574, or the 2018 session, 533, Utahs lawmakers still considered hundreds of bills that will impact the lives of residents.

Here is a look at some of the bills that did, and didnt, make it through the 2020 legislative session:

Bills that passed

Polygamy decriminalization: Sen. Deidre Henderson, R-Spanish Fork, sponsored a bill this session to reclassify bigamy as an infraction instead of a third-degree felony. Henderson said polygamists in Utah are tired of being treated like second-class citizens and feel like Utah has legalized prejudice against them. S.B. 102 received overwhelming support from lawmakers, 19 of whom signed on as co-sponsors. Prosecutors and polygamists testified in legislative committees that decriminalizing bigamy would prevent abuse in polygamist communities and lead to social integration.

Affordable housing: A bill sponsored by Lehi Republican Sen. Jacob Anderegg asked the legislature for $35 million to fund the development of affordable housing and provide rental assistance to families who are at risk of becoming homeless. While S.B. 39s funding was cut to $10 million, it successfully made it through the House and Senate. Anderegg said the bill is the result of work by the states Commission on Housing Affordability and believes it will help low-income Utahns who are legitimately one life event away from being homeless. The $10 million will go into the states Olene Walker Housing Loan Fund and be used to fund housing for low and moderate-income residents.

Violence against Indigenous women task force: Rep. Angela Romero, D-Salt Lake City, introduced a bill to create a Murdered and Missing Indigenous Women and Girls Task Force to study violence experienced by Native American women. The task force would consist of members of the House and Senate, a representative of a Native American victim advocate organization, and the director of the Utah Division of Indian Affairs. Native American women experience domestic abuse, sexual assault and other forms of violence at rates higher than nearly any other group. The House and Senate both passed H.B. 116 unanimously.

Fetal remains disposal: Sen. Curt Bramble, R-Provo, sponsored a bill to require medical facilities to either cremate or bury the fetal remains of abortions or miscarriages, leaving the decision between the two forms of disposition up to the mother. Bramble said the bill gives women more choices and ensures that fetal remains are disposed of in a dignified way. Critics of the bill say women already have a choice over disposition options and that it unnecessarily interferes with the doctor-patient relationship. Lawmakers amended the bill to only focus on abortion, but that amendment was later abandoned.

Abortion prohibition: A bill sponsored by Sen. Dan McCay, R-Riverton, would ban abortions in Utah at any stage of gestation, although it wouldnt go into effect unless the United States Supreme Court overturned its 1973 Roe v. Wade ruling. S.B. 174 passed through both chambers and, if Roe v. Wade were overturned, would make it a second degree felony for a physician to perform an abortion in Utah, with exceptions made for cases of rape, incest, or if the life of the mother were in danger.

Mental health services: A bill sponsored by Rep. Steve Eliason, R-Sandy, will expand Utahs mobile crisis outreach teams and fund the development of a behavior health receiving center. The bill asks for $5.9 million in one-time funds and an additional $10.8 million in ongoing money. H.B. 32 passed through both chambers unanimously. Another bill of Eliasons, H.B. 35, would study the need for adult beds at the Utah State Hospital.

Prosecutor and jail data collection requirements: Provo Republican Rep. Marsha Judkins sponsored a bill that would up the reporting requirements for attorneys offices and county jails throughout the state. Specifically, H.B. 22 would require county jails to compile information on inmate gender, race and ethnicity and require prosecutors to report whether charges were brought or if a plea bargain was reached, among other data points. Judkins said the bill will help increase transparency in Utahs criminal justice system and give lawmakers a better understanding of how to address concerns.

Public education funding: Lawmakers passed a proposal to amend the Utah Constitution to expand how income tax dollars can be spent to allow spending on children and individuals with a disability. Additionally, they passed a bill sponsored by Rep. Robert Spendlove, R-Sandy, to provide growth and stabilization in public education funding.

Pornography labeling: A bill introduced by Rep. Brady Brammer, R-Highland, would require all pornography in state to include a label warning about the harms porn can cause minors. The attorney general or any member of the public would be able to bring action against pornography manufacturers who failed to do so.

Bills that didnt pass

County government changes: Brammer also sponsored a bill this session that would require counties with populations greater than 500,000 to switch to either an executive-council form of government or council-manager form. The bill targeted Utah County, which will ask voters in November whether the county should switch from a three-member commission to a full-time mayor and part-time five-member council. H.B. 257 stalled in the House Political Subdivisions Committee on Feb. 12.

Clergy abuse reporting requirements: Rep. Romero also sponsored a bill this session that would remove child abuse reporting exemptions for clergy members and religious leaders. The bill received pushback from the Catholic League for Religious and Civil Rights, who argued that it would require priests to break the Seal of Confession. The bill was numbered but never made it to a House committee.

Hormone therapy for transgender minors: After abandoning legislation that would ban gender reassignment surgery and hormone therapy for transgender Utahns under the age of 18, Rep. Brad Daw, R-Orem, proposed a bill to study existing research on the health impacts of such practices. Daw said research that puberty blockers like Lupron have been shown to have negative side effects while LGBTQ+ activists said the bill targeted transgender youth. H.B. 449 failed in the House on a 17-55 vote.

Mandatory ultrasounds: West Jordan Republican Rep. Steve Christiansen sponsored a bill that would mandate that physicians performing abortions display fetal images of each unborn child to the mother and make each unborn childs heartbeat audible. All six of Utahs women senators, both Democrats and Republicans, walked off the Senate floor in protest of H.B. 364. While the bill originally passed both chambers, it was held in the House on the last day of the session.

Rent control: Rep. Jennifer Dailey-Provost, D-Salt Lake City, introduced a bill that would give cities and counties the authority to impose rent control measures within their jurisdiction. Currently, there is a state provision prohibiting municipalities from doing so. H.B. 131 was never heard in committee.

Read more:
Polygamy, abortion, affordable housing: What passed during Utah's legislative session - Daily Herald

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Match Q&A: Will You Find What You’re Looking For? – AAFP News

Results of the National Resident Matching Program will be released on March 20. As Match Day drew near, Margaret Miller, student member of the AAFP Board of Directors and a fourth-year medical student at East Tennessee State University's Quillen College of Medicine, met with Kelly Thibert, D.O., M.P.H., resident member of the Board and a third-year resident at the Grant Family Medicine Residency at the OhioHealth Grant Medical Center, to discuss their respective Match experiences.

We're sharing their conversation below for the benefit of others awaiting Match results this week, as well as medical students who will participate in the process in the future. We also have been sharing other fourth-year students' answers to some of these same questions recently on Instagram.(www.instagram.com)

Kelly: Matching is a long process, and you're finally almost at the end. What has it been like for you?

Margaret: My experience is a little unique in that I am "couples matching." My husband is matching into internal medicine, so my experience is probably different than most applicants'. I did a few more interviews than a single applicant might, so that made my interview season longer.

I really didn't anticipate how exhausting the process would be! I like to think of myself as an outgoing person, but you meet a lot of new people and get fed a lot of information at each interview. It can be quite overwhelming sometimes to be traveling, to be away from your partner and trying to imagine yourself as a doctor in a new place you're not familiar with. I'm glad that's behind me. I'm anxious to find out where I'll be going.

What's the Match experience like from the other side, as a resident meeting candidates?

Kelly: The Match process from the resident side is actually really exciting and fun, which is a great change from going through the Match as a student. We get to participate in recruitment season, interview season and, of course, Match Day. Throughout the entire yearlong process of getting to know so many people -- who are potentially going to be part of your program -- you get inspired by all the passion they have and their excitement about becoming family doctors.

One of my favorite things about being a resident on Match Day is that we get to celebrate and welcome new people to our family. As residents, we spend many hours away from our families with this other family. These are people you want to know and love and like. It's exciting to see who is going to be part of your residency family. In my program, we have a Match Day celebration where we close the office during the second half of the day in anticipation of the release of names. This year, the celebration will look a bit different; more technology will be used than we typically would have, and we will not gather together in person to celebrate (social distancing), but we will unveil our newest 10 family members electronically and with no less excitement than any other year. We will then reach out to shower the newest residents with the "Grant Love" that our program is known for. It's really exciting from our end, which is a very different experience from the student perspective.

Margaret: My favorite interviews were definitely the ones where I had great conversations with faculty and residents who inspired me, and I was really excited by the opportunity that I might get to work with them as mentor or role model if I was a resident there. I would agree there are moments that can be really inspiring and invigorating for students as well, but it's still a lot!

What would you tell your pre-Match self if you could go back in time?

Kelly: Probably the biggest thing I would tell myself is just to chill out. I would say, "You have worked so hard to get where you are, from studying all the time to taking board exams and passing board exams. You've gotten to the point where you're about to become a physician. I know the Match is a huge thing and a huge step and it feels like you have no control over it. You have done marvelous things, and great things are coming your way. Things will work out as they will, and now it's out of your hands, so just chill out."

Margaret: I think that's the most difficult thing at this point. Things really are out of my hands. I don't have any control over the process from here on out. I've already sent my rank list and we're just in a waiting period, so good distractions are always welcome.

Kelly: What were you looking for in programs, and do you think you found it?

Margaret: I hope I found it. I definitely think I did at a handful of places.

There are a lot of things across the board that are pretty similar between programs because of certain core requirements that every program has to meet. For me, there were a few things that stood out to make a program different. One would be access to education and training opportunities in particular medical areas that I'm interested in, including hormone replacement therapy and caring for LGBTQ populations, and also a program that incorporated getting certification to do medication-assisted therapy. Other things I am interested in are advocacy and finding a place willing to let me continue working with the AAFP and other organizations.

Having a diverse group of residents was important to me -- people from different backgrounds from different parts of the country, people who look different from me and have different perspectives on medicine.

Lastly, the biggest thing that differentiates a program is the people you meet. I felt like I met more faculty than residents, so for me finding faculty I felt I could be close to, train under and learn a lot from was what I was looking for. I definitely think I found that. I hope I end up at one of those places where I felt like I found it.

Kelly: What are you excited or nervous about, knowing you're soon going to be a family physician?

Margaret: There are a lot of things I'm nervous about, but I'm actually more excited. I feel so ready to move on to the next part of my training.

I'm excited to have my own patients. As a student, you work so much as part of a team and introduce yourself as part of the team. It will be nice to see people over the course of my residency and help them deal with issues over time.

There are parts of medicine I'm nervous about, but the thing I really am hopeful about is that places I interviewed at -- and I would say this about almost all of them -- is that the support systems and faculty at each one really felt passionate about teaching, and that's why they were there. Maybe their particular emphasis of what they were interested in teaching wasn't what I was looking for, but they were still really supportive, kind people who were looking to train great residents, so I feel less nervous than I do excited. I'm more nervous about the Match than I am residency itself.

What have been the most meaningful moments of being a family physician for you?

Kelly: Being able to have my own patients and care for the whole family while practicing full-spectrum family medicine. People often say we are the cradle-to-grave specialty, and it's so true. We care for prenatal patients, deliver their babies and see them in the office with their families. They might bring Grandma in, too, because they liked the way you cared for them. Then you get to care for the whole family, even up through hospice and palliative care, which is a really important part of medicine.

We're so fortunate to be part of patients' lives. They allow us to be part of very intimate moments -- whether good or bad -- sometimes things they don't allow family members to be part of. These have been the most memorable things for me.

But also getting to know more about family medicine. You think you know about the specialty you are matching into, but you don't know the breadth and how incredible the specialty is until you're in it. You get to participate in things like the AAFP and get to know so many more people and the things they are doing in family medicine. I'm inspired daily by the family physicians I meet. I'm really happy I chose this profession and specialty.

Margaret: What's your advice for students transitioning to residency?

Kelly: Don't study. Take a break.

I had a different path to residency. I spent a year doing health policy between medical school and residency, so I felt like I had to study, and I did review some clinical stuff. Looking back, I don't know how much that helped me compared to the things I actually learned firsthand in the hospital. All the things you learned in medical school will help you, but nothing will give you what you need more than just being there and doing it as a resident.

You have worked so hard to get to this point. Take a break and celebrate the fact that you are about to become a family doctor.

So, what would you tell a first-year student already nervous about matching?

Margaret: The Match is definitely not something I worried about as a first-year, and I would not recommend worrying about it as first-year. Focus on the day-to-day of what you are doing. Nothing will prepare you more for your fourth year than first year, second year and third year, each in their time. You have enough on your plate to worry about first year!

As far as tips for nerves in general, try to balance your life the best you can. I think that's different for everyone in medical school. For me it was sometimes yoga or traveling, but it also was vegging out on the couch and watching Netflix after a big test. Getting involved in things that reminded me why I wanted to be a doctor in the first place was my saving grace.

What about your Match experience? When you were going through it, what affected where you applied and what were you looking for?

Kelly: I was all over the place because I was looking specifically for training. Location didn't matter so much because I thought whether I trained in a rural or suburban area, as long as I had the acuity and patient load, I would learn what I needed to learn and could go wherever I wanted, whether that be a rural or suburban setting.

Margaret: Family medicine is so different for different people. What kind of questions were you asking on the interview trail?

Kelly: It's funny because I was asking a lot of same questions you asked. I was looking for MAT training, gender-affirming care experiences, comprehensive reproductive health care, opportunities to participate in advocacy and social justice, and the ability to remain involved in the Academy. I think all those things are important.

Patients are so often marginalized and people might not have the bandwidth or knowledge set to provide these aspects of care. It's such a passion of mine. I wanted to be able to provide these things for patients no matter where I ended up.

I also was looking for places where I would be heavily trained in inpatient care and obstetrics. I feel wholeheartedly that it's important to be trained in inpatient and obstetric medicine as a family medicine doctor. We need to understand what has medically happened during a patient's admission because we then continue to manage the outcomes once they are discharged -- some of us even continue to care for patients in those inpatient and obstetric settings as family medicine doctors.

That's what's great about family medicine: We have such a breadth of practice that one can always find what they're looking for.

Margaret: Did you find all the things you were looking for?

Kelly: I 100% did, which is really incredible.

The rest is here:
Match Q&A: Will You Find What You're Looking For? - AAFP News

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Angiotensin and the Coronavirus – Science Magazine

Theres quite a bit of confusion around the ACE proteins and coronavirus infection, and I can see why. The names in this area are pretty confusing, for one thing, and if youre not familiar with the tangled feedback loops that you get in human biology, it all starts to look like a tangle of wires pretty quickly. So lets have a look at the outlines of the system.

At right is a (pretty darn simplified) scheme. Angiotensinogen is a 452-amino-acid protein thats secreted by the liver (and has several functions all by itself). Its first ten amino acids are cleaved off by the enzyme renin to give you Angiotensin-I (also known as proangiotensin). That small peptide is then made even smaller by angiotensin-converting enzyme 1 (ACE-1), and interestingly, no ones ever found a function for angiotensin-1 other than to sit around and get cleaved in this way. This extra regulatory step has presumably come in handy over the eons.

ACE-1 takes off two more amino acids to give you the octapeptide known as angiotensin-II, and that one has profound effects on raising blood pressure (it has many other functions as well). It does this by binding to cell-surface proteins called angiotensin receptors (theres more than one type of these and they have a whole list of other downstream functions, but that takes us further afield). So you can see how an ACE-1 inhibitor could be good for high blood pressure, by blocking any formation of angiotensin II, and a renin inhibitor would be as well, by blocking the whole process a bit further upstream, and something that blocked that last binding step (an antagonist of the angiotensin receptor) would also probably work. All three of those are in fact classes of hypertension drugs the ACE-1 inhibitors came first (captopril in 1980, a famous triumph of 1970s med-chem and led to a whole slew of improved -opril drugs). The angiotensin receptor blockers came next (drugs with the -sartan suffix), and there are several of them. Renin inhibitors were far more painful to discover and develop, for a lot of reasons, and theres still only one on the market (from 2007).

Now to the coronavirus connection. Youll note that ACE-2 enzyme in the chart, and that one (formerly rather obscure) is having its moment in the the spotlight. Its expressed near the surface of various epithelial cells blood vessels, for sure, but also lung, intestine, and others. As shown, it is capable of clipping both angiotensin-I and angiotensin-II down further, to even small peptides (angiotensin 1-9 and 1-7) that have activities of their own. So it has its cardiovascular roles to play, but its become known for being a protein recognized by various coronaviruses to gain cell entry. There are others, naturally, and their relative importance can differ from virus to virus, but ACE-2 was shown to be important for the earlier SARS virus, and this current SARS-CoV-2 is quite similar. A cryo-EM structure of full-length ACE-2 with a coronovirus spike protein has recently appeared.

So something that binds to ACE2 and interferes with that viral hijacking would probably be quite interesting. Problem is, we dont have much of anything like that. ACE-1 inhibitors, as fate would have it, are not inhibitors of ACE-2 the enzymes are cousins, but not similar enough for the activity to cross over. Its not completely clear to me if a small molecule inhibitor in the active site would interfere with the viral interaction anyway, and it would be nice to have a few to see, but Im not aware of any such compounds. The confusion around the phrase angiotensin receptors has led to some people outside of the medical field wondering if the antagonist drugs (the sartans) would interfere with ACE-2, but that doesnt happen, either (theres another story with those, though see below).

A recent letter to The Lancet has noted that comorbidities reported so far for severe coronavirus patients include hypertension and either type I or type II diabetes. These patients are often being treated with ACE-1 inhibitors or angiotensin-receptor antagonists. The tricky part is that both diabetes itself and treatment with either of those drug classes increases the expression of ACE-2 protein. At first thought, that would probably not be a good thing, loading up the cells with more viral target proteins. But wait: theres another effect, as noted in this new paper. It builds on reports from China to suggest that a mechanism of lung injury during the viral infection may be through inappropriate effects of excess free angiotensin-II protein, which is floating around out there because the ACE-2 that would normally be soaking it up is occupied by coronavirus particles. If thats the problem, then increasing the amount of ACE-2 protein might paradoxically be just what you want to do to restore some balance to the angiotensin system. In that case administering more angiotensin receptor antagonists would be an effective way to upregulate the production of ACE-2.

There are a lot of such bounce-shot three-cushion mechanisms out there, so its not a crazy suggestion. That second paper proposes sorting through the existing patient data to see if there are correlations between severity of infection and angiotensin receptor antagonist therapy in particular, and I believe that this is ongoing. Epithelial cells are going to have ACE-2 protein on their surfaces no matter what, so the virus is going to be attacking those as a route of entry. If that second paper is right, then it could be that throwing more ACE-2 onto those membrane doesnt make the viral infection much worse, but does lessen the associated lung injury. If were going to have a lot more coronavirus patients, this would be a very good thing to know.

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Angiotensin and the Coronavirus - Science Magazine

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Your circadian rhythm is the key to good sleep — here’s how to regulate it – CNET

Find out how to optimize your circadian rhythm so you can sleep better.

What do blue-light blocking glasses, sleep trackers, tech fasts and sleep supplements all have in common? Besides the fact that they are meant to help you sleep better, they all, in some way, attempt to help you regulate or optimize your circadian rhythm.

Read more:8 products to help you stop snoring

Your circadian rhythm is the internal "clock" that helps your body function, adapt and yes -- sleep. The two things that affect your circadian rhythm the most are environment and light, according to Dr. Craig Heller, Professor of Biology at Stanford where his research focuses on sleep and circadian rhythms. And while controlling your environment and light around you seems a bit difficult (read: impossible), there are definitely things you can do to reduce the risk that you are disrupting your circadian rhythm more than necessary.

To learn more about your circadian rhythm, how it works, and what you can do to optimize it so you will sleep better, keep reading.

Now playing: Watch this: Do these 8 things to sleep better tonight

2:38

Your circadian rhythm is your internal clock that runs on a 24-hour cycle. This internal clock tells your body when you feel tired or awake throughout the day. You've probably noticed you have a pattern of when you feel the most awake or energized, and when you usually want to take a nap. The circadian rhythm is what drives that pattern, but not everyone has the same patterns.

Your body has an "internal clock "system known as the circadian rhythm.

"Circadian rhythms are internal cycles in many body systems and behavior that have a periodicity. Circadian systems enable the body to anticipate future events (e.g., food availability), coordinate body functions (e.g., sleep and hormone release), and optimize physiological processes with respect to each other," Heller says.

Since your circadian rhythm helps regulate many important processes in your body, it makes sense that disrupting it is bad news for your sleep, and therefore your health in general.

So what exactly disrupts your circadian rhythm the most? "Most commonly jet lag, shift work, bright light and especially blue light (computer and TV screens) when it should be dark," Heller says. Another big circadian rhythm disruption is when you transition to daylight saving time.

Signs that your circadian rhythm is disrupted include problems falling asleep, feeling energized or wired at unusual times, or feeling super tired for periods during the day. One thing that can help keep your circadian rhythm on track is trying to stick to a consistent sleep and wake-up time, which is not always easy.

Here are a few things to try if you think your circadian rhythm is off:

Keep a consistent sleep and wake up time: and try to keep it close to what feels natural to you (i.e., don't fight the fact that you are a night owl or morning person)

Get light in the morning: Get sunlight in your eyes first thing in the morning when you can. Getting light early in the day tells your body it's time to "wake up."

Avoid bright lights in the evening: Like Heller said, light can affect your circadian rhythm, which is why avoiding bright lights in the evening and dimming your lights can make a difference.

Avoid blue light at night: Turn off the TV and other devices that emit blue light at least three hours before bed. If you can't turn them off completely, install an app likeF.lux or wear blue light or amber-tinted glasses to block the light.

Traveling across time zones can disrupt your body's internal clock.

Sometimes your job or lifestyle forces you to do things you know aren't great for your sleep, but you want to make the best out of your situation regardless. Activities like working nights or traveling across time zones -- especially when the time difference is more than a few hours -- can really wreak havoc on your sleep.

"Presumably, you can't avoid travel across time zones or shift work, so you can learn the best ways to retrain rhythms by appropriate timing of light exposure and practice of good sleep hygiene," Heller says. "Apart from circadian considerations, there are many other things to do to improve sleep, most effectively through thermoregulation to support the temperature fluctuations of the body to maintain sleep continuity."

Now playing: Watch this: Pandemic: Here's what's changed about the coronavirus

5:54

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

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Your circadian rhythm is the key to good sleep -- here's how to regulate it - CNET

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RELIEF THERAPEUTICS HOLDING SA (SIX: RLF) Announces Plans to Test Aviptadil for the Treatment of COVID-induced Acute Respiratory Distress Syndrome…

GENEVA--(BUSINESS WIRE)--RELIEF THERAPEUTICS Holding SA (SIX-RLF, Relief or the Company) is initiating an urgent phase 2 clinical trial of RLF-100 (Aviptadil) in coordination with the Senior Leadership of the Government of Israel for the treatment of Acute Respiratory Distress Syndrome (ARDS) in patients with COVID-19 infection. The trial is being coordinated by Prof. Jonathan Javitt, MD, MPH, acting Chairman of the Scientific Advisory Board of Relief in coordination with Dr. Miki Halberthal, MD, CEO of the Rambam Healthcare Campus and Dr. Boaz Lev, head of Israels COVID task force and former Director General of Israels Ministry of Health.

RLF-100, acquired by Relief from Mondo Biotech, AG, has Investigational New Drug clearance from the US FDA and the European Medicines Agency for phase 2 trials in ARDS and has been awarded orphan drug designation by both agencies for treatment of ARDS, Acute Lung Injury, and Sarcoidosis. Aviptadil is Vasoactive Intestinal Polypeptide (VIP), a naturally-occurring peptide hormone that is known to be concentrated in the lungs. VIP has been shown in five species of animal models to have potent effect in models of ARDS and Acute Lung Injury. In these models, Aviptadil has shown potent anti-inflammatory and specifically anti-cytokine activity in the lungs.

The first clinical protocol will compare intravenous administration of Aviptadil to its administration via an endotracheal tube in patients who are already on mechanical ventilation because of ARDS. Assuming no new safety signals are detected, a second protocol will quickly be initiated to treat patients with early signs of respiratory distress in the hopes of preventing progression to ARDS and the need for mechanical ventilation.

After carefully reviewing the preclinical and clinical data, we believe that RLF-100 has a chance to be a safe and effective treatment for Acute Respiratory Distress Syndrome in patients infected by COVID-19, who otherwise have less than 50% chance of survival, despite intensive care. The State of Israel is eager to test this potentially lifesaving treatment in patients who today have no other therapeutic option, said Dr. Halberthal. We will try every possible mechanism to help safeguard our patients in this global crisis.

As a third-generation physician and the father of newly-trained physician, I am deeply honored to be working with longtime colleagues in Israels Ministry of Health on critical initiative. Owing to the rapidly expanding size of the epidemic and the extraordinary unmet medical need, we intend to initiate phase 2 clinical trials on an urgent schedule in order to bring a potentially life-saving drug to patients.

About RLF-100

RLF-100 (Aviptadil) is a patented formulation of Vasoactive Intestinal Polypeptide (VIP) that was originally developed and is currently marketed in Europe for the treatment of erectile dysfunction. VIP is known to be highly concentrated in the lung and to inhibit a variety of inflammatory cytokines. Aviptadil was awarded Orphan Drug Designation in 2001 by the US FDA for treatment of Acute Respiratory Distress Syndrome and in 2005 for treatment of Pulmonary Arterial Hypertension. Aviptadil was awarded Orphan Drug Designation by the European Medicines Agency in 2006 for the treatment of Acute Lung Injury and in 2007 for the treatment of Sarcoidosis. Both the US FDA and the EMEA have granted Investigational New Drug licenses for human phase 2 trials of Aviptadil.

About Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. Symptoms include shortness of breath, rapid breathing, and bluish skin coloration. Among those who survive, a decreased quality of life is relatively common.

Causes may include viral infection, sepsis, pancreatitis, trauma, pneumonia, and aspiration. The underlying mechanism involves diffuse injury to cells which form the barrier of the microscopic air sacs of the lungs, surfactant dysfunction, activation of the immune system, and dysfunction of the body's regulation of blood clotting. In effect, ARDS impairs the lungs' ability to exchange oxygen and carbon dioxide.

The primary treatment involves mechanical ventilation together with treatments directed at the underlying cause. The syndrome is associated with a death rate between 35 and 50%.

RELIEF THERAPEUTICS Holding SA is listed on the SIX Swiss Exchange under the symbol RLF. For further information, please visit the Relief website at http://www.relieftherapeutics.com or contact at contact@relieftherapeutics.com

Disclaimer: This communication expressly or implicitly contains certain forward-looking statements concerning RELIEF THERAPEUTICS Holding SA and its business. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of RELIEF THERAPEUTICS Holding SA to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. RELIEF THERAPEUTICS Holding SA is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.

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RELIEF THERAPEUTICS HOLDING SA (SIX: RLF) Announces Plans to Test Aviptadil for the Treatment of COVID-induced Acute Respiratory Distress Syndrome...

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Why Do Some People Eat When Stressed, While Others Stress-Starve – The Swaddle

Ah, stress. That inevitable, commonplace pandemic. Everyones stressed in the 21st century, and nobody seems to think it too much of a big deal, until that seemingly slight mental turbulence starts exerting a serious negative influence upon our health and daily functioning.

Stress is the bodys attempt to adapt to any unusual negative changes that it must face. For me, stress manifests in the way I eat. When Im stressed to a certain extent, I need copious amounts of chicken-cheese momos, or a batch of spicy fries. Then, as my stress progresses to something worse, I cant eat no matter how hard my gut groans for food. Why do I eat when Im stressed? And why cant I eat when I become more stressed?

Apparently, I am not unique. People tend to overeat when theyre stressed in order to distract themselves from whatever is on their minds. And people stop eating when theyre stressed because they simply cannot take their minds off whats stressing them, killing the need to do other things.

Related on The Swaddle:

Stress Is Contagious, but Heres How We Can Avoid Infecting Each Other

According to Harvard Health, feeling stressed makes our brain send cues to our bodies that it thinks might help us deal with the threat weve recognized. This is done via the stress hormone cortisol, which makes us crave food especially of the sugary, salty, fatty sort because it helps stock up on energy to fight whatever threat were dealing with. Increased stress also leads to a drop in metabolism, which can lead to rapid weight gain.

On the other hand, stress also stimulates the brain to secrete hormones like corticotropin-releasing factor (CRF), which activates the sympathetic nervous system that brings about the fight-or-flight response. Hormones like CRF are known to suppress appetite, decreasing how much or often we feel hungry, Dr. Kimbre Zahn, a family physician, told Shape. She adds, Individuals with persistent stress or those affected by generalized anxiety may be more likely to have chronic elevations of these hormones, resulting in prolonged appetite suppression. Often, stress can also lead to feeling nauseous, which also kills an individuals appetite. Losing ones appetite is particularly hard on the body, as increased cortisol leads to increased production of acid in the stomach. And if theres nothing but acid in the stomach, the organ will develop ulcers.

In any case, either eating too much or not eating at all, especially when stressed, are particularly bad habits, as they aid to the bodys struggle to cope. To avoid stress eating, take refuge in other comforting behaviors rather than eating junk food for example, eating healthy snacks and/or talking to a friend. As for a lack of appetite, what helps is to find foods that one can eat without feeling intense nausea. And drinking smoothies or milkshakes, which are easy to digest, will ensure the body has enough calories to keep it going through that turbulent period.

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Why Do Some People Eat When Stressed, While Others Stress-Starve - The Swaddle

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Guilford, East Haven, North Branford receive expired respirators from national stockpile – New Haven Register

The expired box of 35 respirators the North Branford Fire Department Chief William Seward says his team received on March 20, 2020 from the national stockpile amid the coronavirus crisis.

The expired box of 35 respirators the North Branford Fire Department Chief William Seward says his team received on March 20, 2020 from the national stockpile amid the coronavirus crisis.

Photo: Contributed Photo / William Seward

The expired box of 35 respirators the North Branford Fire Department Chief William Seward says his team received on March 20, 2020 from the national stockpile amid the coronavirus crisis.

The expired box of 35 respirators the North Branford Fire Department Chief William Seward says his team received on March 20, 2020 from the national stockpile amid the coronavirus crisis.

Guilford, East Haven, North Branford receive expired respirators from national stockpile

North Branford Fire Chief William Seward was alarmed when he got the news: his department, which runs the towns ambulance service, would only receive one box of 35 respirators from the strategic national stockpile.

Whats more, all of those masks which Seward picked up today in Essex are expired.

Its beyond belief, Seward said. Although the town currently has enough supplies on hand, Seward worries about what will happen if COVID-19 cases spike a few weeks down the road, he said.

North Branford is not alone.

Two East Haven firefighters and their families were quarantined for two weeks Friday after the pair of first responders assisted a 79-year-old man who became the towns first confirmed case of COVID-19, the town said in a statement.

East Haven Fire Chief Marcarelli is worried that if too many members of his team get sidelined because of exposure, they wont be able to fight fires, he said.

The department is supporting them and their families and both firefighters are doing well, Marcarelli said.

Marcarelli was told that all of the 144,000 respirators in the states strategic stockpile are expired by at least 10 years, he said, adding that his department was allotted 220 respirators. They were all expired, and they were all sized small, he said.

And I dont know why any of this is coming as a surprise to the state, Marcarelli said. Theres been a pandemic plan since 2001.

The state is a major source of the respirators, which are currently difficult to find, according to Marcarelli.

Further down the Shoreline, Guilford got 110 respirators also expired, according to Assistant Fire Chief Michael Shove.

A memorandum from Lisa Bushnell, strategic national stockpile coordinator for the Connecticut Department of Public Health, indicates that in terms of personal protective equipment, many towns in the state are only receiving expired respirators at this time.

The Department of Public Health (DPH) is in possession of expired N95 respirators manufactured in 2006 that were not granted a shelf-life extension by the federal government, the memo says. We requested that the federal government consider an extension given the national PPE shortage, which was not granted. These expired Kimberly Clarke N95 respirators will not provide the appropriate protection factor of non-expired N95s, but are likely to minimally provide protection equivalent to a surgical face mask.

Hearst Connecticut Media obtained a copy of the letter, dated Thursday. Bushnell directed press inquiries to DPH spokesman Av Harris, who did not respond to a request for comment.

The state Department of Emergency Management and Homeland Security divides Connecticut into five regions, according to its website. The memorandum about the expired respirators went out to Region 2 towns, according to an email to which the record is attached.

Thirty Connecticut towns make up Region 2, according to the DEMHS website.

Guilford Assistant Fire Chief Michael Shove confirmed that his town is also facing a challenge in terms of access to PPE. Eligible for 105 respirators, his department received more equipment than the North Branford Fire Department but, again, all those respirators were expired, Shove said.

The state used each departments call volume to determine how many respirators they would receive, according to the email sent to Region 2 towns.

But the North Branford Fire Department transports more than 900 patients annually, Seward said, adding that the respirators are not reusable.

Whats more, medical experts today expanded the possible symptoms associated with COVID-19 so as to include certain gastrointestinal issues, according to Seward. That means personal protective equipment may be necessary for more calls, Seward said.

Shove confirmed Sewards account.

Although calls in North Branford are currently less frequent than normal, if COVID-19 cases surge, Seward said, the lack of personal protective equipment will be a challenge for us.

And its not just respirators first responders need. They also require gear like gloves and gowns, Shove said.

Shove hopes that Connecticut is able to prevent the surge in COVID-19 cases, or that manufacturers can ramp up PPE production, he said.

Hes not worried about the next two weeks, but he is worried about having sufficient supplies thereafter.

We could definitely use supplies, but theres nowhere to get supplies, he said, adding that many departments are in the same boat. All the chiefs have been vocal ... but the thing is, you cant change the past.

Shoves team will make the most of what they have, he said.

meghan.friedmann@hearstmediact.com; 781-346-5236; Mark Zaretsky contributed to this report.

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Guilford, East Haven, North Branford receive expired respirators from national stockpile - New Haven Register

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HP Collaborates With Amy Karle, Leading 3D Printing Artist and Futurist – CSRwire.com

HP 3D printing helps to unleash new levels of creative expression from the human heart to a Triceratops

- HP highlights collaboration with cutting edge artist Amy Karle in honor of International Womens Week

- Karle leverages HPs 3D printing to create custom works of art in various materials and full color for world renowned museums such as the Smithsonian and Mori Art Museum

- The artists work seeks to explore how technology could be utilized to unlock human potential

HP Inc. news

PALO ALTO, Calif., March 20,2020 /CSRwire/ -This Womens History month, HP is showcasing a collaboration withAmy Karle, a leading artist, provocateur and futurist. Regarded as one of the most influential women in the 3D printing industry today and one of theBBCs 100 Women,Amy Karle is leveraging the power of 3D printing to reinvent creating art in amazing new ways. HPs 3D Printing & Digital Manufacturing organization and HP Labs are working together with Amy Karle to provide the most advanced 3D printing solutions to make her creative art expression a reality.

I love the exploration and development that 3D printing offers: a new opportunity for thinking, a new way to reshape what we create, and a completely new approach to expression in which digital, physical and biological systems are interwoven, said Amy Karle. HP 3D Printing enables me to bring this vision to life by opening up new artistic possibilities not achievable before.

Amy Karles mission is to positively impact others, raise consciousness and contribute to social, political, and technical development by making and sharing her work. As an artist and designer, Karle uses HP Multi Jet Fusion technologies which include the Jet Fusion 5200 and 580 printing systems to build her pieces, creating art that catalytically examines material and spiritual aspects of life and opens minds to future visions of how technology could be utilized to unlock human potential.

Amy Karle Smithsonian Collaboration: Regeneration Through Technology Sculpture Series

Leveraging Smithsonian 3D scan data of a fossilized Triceratops skeleton as the basis of inquiry into the past, present, and future, Karle recently debuted artworks inspired by scans the Smithsonian Digitization Office made of an object in the collection of the Smithsonians National Museum of Natural History in conjunction with the launch of theSmithsonian Open Access Initiative.

The basis for this collection by Karle is Hatcher, a 66-million-year-old Triceratops skeleton in the National Museum of Natural History who made history as the first digital dinosaur. In the context of cutting-edge digital, biotechnological, computational, and additive manufacturing developments, Karle expands on Hatchers legacy by opening an inquiry into what representation and composite with computer-assisted technology means for us now and into the future. See Karles artworks for this collaboration, Deep Time and The Far Future,3D printed by HP here. For more about the Smithsonian collaboration, clickhere.

view a full slidgeshow of Amy's work here

Amy Karle The Heart of Evolution?

Questioning human modification at the dawn of the biotech era, and how future organs and the augmented body could be created and function in the future, Karles The Heart of Evolution? sculpture takes shape of what heart vasculature could look and work like with enhanced design, housed in the mechanical womb of a scientific bioreactor. The artist chose a heart shape because it is a major organ often associated with the emotions to heighten the viewers awareness of synthetic biology's potential implications on humanity and evolution - both positive (for healing and enhancing) and negative.

The work questions life, death, life extension, enhancement, and transformation at a time of humans and technology merging. The work points to the importance of considering and collaboration with living systems; and serves to open minds to visions of how design, generative engineering, 3D printing, and bioprinting can heal and enhance humanity. Now on display at the Mori Art Museum in Tokyo, Japan, see photos of Karles The Heart of Evolution? 3D printed by HP in the image gallery and watch thisvideo.

About Amy Karle

Amy Karle attended Alfred University and Cornell University, where she received degrees in Art and Design and Philosophy. Karle is co-founder of Conceptual Art Technologies and has shown work in 46 exhibitions worldwide. She is the inventor of registered active patents, service marks and trademarks in medical and technology categories.

Amy works as a full-time artist expressing experiences in visual forms, often designing technologies to improve the body and functions of the human in the process. She has been named one of the Most Influential Women in 3D Printing and her bioart work has contributed to the establishment of a new discipline in the art world. The long-term goals of her work are to continue to pioneer in the bioart field and make contributions to healthcare and mind-body medicine in the process.

About HP

HP Inc. creates technology that makes life better for everyone, everywhere. Through our portfolio of personal systems, printers, and 3D printing solutions, we engineer experiences that amaze. More information about HP Inc. is available atwww.hp.com/go/3Dprinting.

Jennifer Baumgartner, HP Inc.Jennifer.Baumgartner@hp.com

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HP Collaborates With Amy Karle, Leading 3D Printing Artist and Futurist - CSRwire.com

Recommendation and review posted by Bethany Smith

Stressed out by coronavirus? Here are 7 simple things you can do right now to relax – Minneapolis Star Tribune

Does the coronavirus pandemic have you feeling anxious? Unfortunately, that might compound the problem. Stress can weaken the immune system. How about something thats been proven to reduce stress and help people fight off the cold virus: a big hug. On second thought, maybe not. Exercise can reduce stress. Of course, no gyms or yoga studio are still open. But there are a bunch of other ways to ease your worries that are cheap, relatively easy and still allow you to maintain your social distance. Here are seven of our favorites:

Chew gum

A surprising number of studies (only a few of which were funded by the Wrigley Science Institute) have shown that chewing gum reduces anxiety. For example, researchers in Japan found that test subjects asked to chew mint-flavored gum twice a day for 14 days reported lower levels of anxiety and mental fatigue compared with a control group that got just a mint.

In the words of the American Institute of Stress: There is little doubt that chewing gum can be a powerful stress buster. One has only to look at a tightly contested baseball game on TV to see how many players, coaches and managers are vigorously chewing bubble gum or something else to relieve their pent-up tension.

Say amen

Feeling lonely because youre forced to work at home or need to practice social distancing? Try talking to God.

Shane Sharp, a Northern Illinois University sociologist who has studied prayer, said many people are able to manage negative emotions through prayer.

Sharp said prayer basically is communicating with an other who can make the situation less threatening.

People, when they pray, it makes salient in their minds that God loves and cares for them, Sharp said.

If you go down on your knees, you wont be alone. Sharp said about 70% of Americans pray at least once a week.

Give thanks

Being thankful or expressing gratitude can help with relationships, stress and depression.

One method might be to keep a gratitude journal, where you regularly write down things youre grateful for.

Sarah Moe, CEO of Sleep Health Specialists in Minneapolis, suggests something even simpler.

She asks clients who have trouble getting to sleep to say aloud three things they are grateful for before they close their eyes or if they wake up in the middle of the night and have trouble falling back to sleep.

Hearing your own voice remind you all that you have to be grateful for seems to improve relaxation and reduce stress, Moe said.

Ground yourself

Its starting to get warm enough to go barefoot outside, and thats a healthy thing, according to advocates of a practice called grounding or earthing.

Biohackers and health gurus like Deepak Chopra say that giving our bodies a chance to connect to the subtle electrical charge of the Earth can help with stress, mood, pain and inflammation.

They recommend going barefoot on the concrete, soil or grass outdoors for a half-hour at a time, or using grounding devices that will give you that connection while indoors.

Yuk it up

It might not hurt to try to find the humor in the situation.

According to the Mayo Clinic, laughter can be a great form of stress relief, stimulating circulation, aiding muscle relaxation, enhancing the intake of oxygen-rich air, increasing endorphins released by your brain, even improving your immune system.

When youre short on laughs, Mayo recommends everything from comic strips to funny movies. Even laughing at not anything in particular can help.

Even if it feels forced at first, practice laughing. It does your body good, according to the Mayo Clinic.

If you want to find something funny about the pandemic, check out the YouTube videos on the creative, hands-free Wuhan shake.

Or, if youre working from home, take a break with the viral BBC dad video, described as every work-from-home parents nightmare.

Yarn bomb it

Knittings meditative, repetitive rhythm has been shown to reduce blood pressure, lower depression and anxiety and increase a sense of well-being. Manipulating soft, soothing yarn has been compared to yoga in its ability to create a relaxed state.

If you start now, youll have a head start on the Craft Yarn Councils Stitch Away Stress campaign in April.

Heavy petting

Just 10 minutes spent petting a dog or a cat has been shown to reduce levels of a major stress hormone, according to a study conducted at Washington State University.

Oh, by the way, the American Kennel Club, the World Health Organization and the Centers for Disease Control say that pets arent affected and are not a source of infection for COVID-19.

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Stressed out by coronavirus? Here are 7 simple things you can do right now to relax - Minneapolis Star Tribune

Recommendation and review posted by Bethany Smith

The Sound of Science – ‘Nina Tandon’ | WNIJ and WNIU – WNIJ and WNIU

The Sound of Science - 'Nina Tandon' (March 20, 2020)

Alexis: Welcome to the Sound of Science on WNIJ. Im Alexis from NIUSTEM Outreach.

Idalia: And Im Idalia. Todaywe will be discussing American biomedical engineer, Nina Tandon.

Alexis:Dr. Tandongrew upin New York City with two siblings with visual impairments. Its no wonder why she chose toinvestigatethe electrical currents that underline the nervous system.

Idalia:As a kid, she often took apart electronics to try to understand them from the inside out.

Alexis:Tandon went on to study Biomedical Engineering and earned her PhD from Columbia. She focused her research on studying electrical signals in engineered tissues, such as cardiac, skin, bone, and neural tissues.

Idalia:Her studies in both bioengineering and business came together as she and a colleague created EpiBone, the worlds first company to grow living human bones for skeletal reconstruction. EpiBoneuses stem cells from patients in need of new bones to produce skeletal structures based on each individual DNA profile.This decreases rejection, simplifies surgeries, and shortens recovery time.

Alexis:SinceDr. Tandon madesuch a giant leap for bioengineering innovation, its clear why she received awards such as "One of the 100 Most Creative People in Business" byFast Companyand "Global Thinker" byForeignPolicy.

Idalia:She is an inspirational woman who completed what was once thought to be impossible.Yet, sheis far from being done.Her companys bioengineered tissues are being used for testing pharmaceuticals without using rats or humans. She says Our process is essentially transforming biotechnology and pharmacology into information technology, helping us discover and evaluate drugs faster, more cheaply and more effectively.

Alexis: Tune in next week where wego into detail aboutmore women in STEM.This has been the Sound of Science on WNIJ.

Idalia: Where you learn something new every day.

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The Sound of Science - 'Nina Tandon' | WNIJ and WNIU - WNIJ and WNIU

Recommendation and review posted by Bethany Smith

Stem Cell-Derived Cells Value Projected to Expand by 2019-2025 – 3rd Watch News

In this new business intelligence Stem Cell-Derived Cells market report, PMR serves a platter of market forecast, structure, potential, and socioeconomic impacts associated with the global Stem Cell-Derived Cells market. With Porters Five Forces and DROT analyses, the research study incorporates a comprehensive evaluation of the positive and negative factors, as well as the opportunities regarding the Stem Cell-Derived Cells market.

With having published myriads of Stem Cell-Derived Cells market reports, PMR imparts its stalwartness to clients existing all over the globe. Our dedicated team of experts deliver reports with accurate data extracted from trusted sources. We ride the wave of digitalization facilitate clients with the changing trends in various industries, regions and consumers. As customer satisfaction is our top priority, our analysts are available 24/7 to provide tailored business solutions to the clients.

Request Sample Report @ https://www.persistencemarketresearch.co/samples/28780

The Stem Cell-Derived Cells market report has been fragmented into important regions that showcase worthwhile growth to the vendors Region 1 (Country 1, Country 2), region 2 (Country 1, Country 2) and region 3 (Country 1, Country 2). Each geographic segment has been assessed based on supply-demand status, distribution, and pricing. Further, the study provides information about the local distributors with which the Stem Cell-Derived Cells market players could create collaborations in a bid to sustain production footprint.

key players in stem cell-derived cells market are focused on generating high-end quality cardiomyocytes as well as hepatocytes that enables end use facilities to easily obtain ready-made iPSC-derived cells. As the stem cell-derived cells market registers a robust growth due to rapid adoption in stem cellderived cells therapy products, there is a relative need for regulatory guidelines that need to be maintained to assist designing of scientifically comprehensive preclinical studies. The stem cell-derived cells obtained from human induced pluripotent stem cells (iPS) are initially dissociated into a single-cell suspension and later frozen in vials. The commercially available stem cell-derived cell kits contain a vial of stem cell-derived cells, a bottle of thawing base and culture base.

The increasing approval for new stem cell-derived cells by the FDA across the globe is projected to propel stem cell-derived cells market revenue growth over the forecast years. With low entry barriers, a rise in number of companies has been registered that specializes in offering high end quality human tissue for research purpose to obtain human induced pluripotent stem cells (iPS) derived cells. The increase in product commercialization activities for stem cell-derived cells by leading manufacturers such as Takara Bio Inc. With the increasing rise in development of stem cell based therapies, the number of stem cell-derived cells under development or due for FDA approval is anticipated to increase, thereby estimating to be the most prominent factor driving the growth of stem cell-derived cells market. However, high costs associated with the development of stem cell-derived cells using complete culture systems is restraining the revenue growth in stem cell-derived cells market.

The global Stem cell-derived cells market is segmented on basis of product type, material type, application type, end user and geographic region:

Segmentation by Product Type

Segmentation by End User

The stem cell-derived cells market is categorized based on product type and end user. Based on product type, the stem cell-derived cells are classified into two major types stem cell-derived cell kits and accessories. Among these stem cell-derived cell kits, stem cell-derived hepatocytes kits are the most preferred stem cell-derived cells product type. On the basis of product type, stem cell-derived cardiomyocytes kits segment is projected to expand its growth at a significant CAGR over the forecast years on the account of more demand from the end use segments. However, the stem cell-derived definitive endoderm cell kits segment is projected to remain the second most lucrative revenue share segment in stem cell-derived cells market. Biotechnology and pharmaceutical companies followed by research and academic institutions is expected to register substantial revenue growth rate during the forecast period.

North America and Europe cumulatively are projected to remain most lucrative regions and register significant market revenue share in global stem cell-derived cells market due to the increased patient pool in the regions with increasing adoption for stem cell based therapies. The launch of new stem cell-derived cells kits and accessories on FDA approval for the U.S. market allows North America to capture significant revenue share in stem cell-derived cells market. Asian countries due to strong funding in research and development are entirely focused on production of stem cell-derived cells thereby aiding South Asian and East Asian countries to grow at a robust CAGR over the forecast period.

Some of the major key manufacturers involved in global stem cell-derived cells market are Takara Bio Inc., Viacyte, Inc. and others.

The report covers exhaustive analysis on:

Regional analysis includes

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To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

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Stem Cell-Derived Cells Value Projected to Expand by 2019-2025 - 3rd Watch News

Recommendation and review posted by Bethany Smith

Boys with older brother more likely to be gay: Study – Calgary Sun

An older male influence in your family might have something to do with your sexuality, a study suggests.

According to a study published in journal Proceedings of the Royal Society B, research has revealed that having an older brother increases mens chances of being homosexual.

The studys researchers analyzed 10 separate sexual orientation studies that involved 5,400 men with info regarding their birth order.

The study revealed that men with older brothers have a 38% higher likelihood of being gay compared to men who dont have an older brother.

(Older) brothers increase the probability of homosexuality in later-born males, the study noted.

The information presented also showed that the more older brothers a man had, the higher chance that he would be homosexual. The study stated having three older brothers doubled a mans chances of being gay.

The study also found that mothers of homosexual males bear more children compared to mothers of heterosexual males.

David Spiegelhalter, a statistician and professor at the University of Cambridge, told the Daily Mail that the fascinating study estimates that having an older brother increases the odds of being gay by 38%, supporting the idea that a mothers immune response to having a male child influences subsequent boys.

People have endlessly argued about the possible roles of genetics and upbringing, but this clear result fits in neither category, he said.

The researchers failed to find a connection between sexuality and birth order for women, noting theres no pattern of siblings, their gender or age that would help determine whether a female would be a lesbian.

Much prior research has shown that females do not influence the sexual orientation of their younger siblings, and females sexual orientation is not affected by their numbers of older siblings, study author Dr. Ray Blanchard stated in an interview with the Daily Mail.

The studys authors state they arent sure why their findings are the case, stating they believe it may be attributed to a theory known as maternal immune hypothesis which believes women who give birth to male babies develop antibodies that impact brain development of future male children they have.

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Boys with older brother more likely to be gay: Study - Calgary Sun

Recommendation and review posted by Bethany Smith

CRISPR RNA-targeted genetic screen could be used for COVID-19 therapy – Drug Target Review

A new Cas13 RNA screen has been used to establish guide RNAs for the COVID-19 coronavirus and human RNA segments which could be used in vaccines, therapeutics and diagnostics.

A novel CRISPR-based editing tool that enables researchers to target mRNA and knockout genes without altering the genome has been developed. Using the CRISPR-Cas13 enzyme, researchers have created a genetic screen for RNA, currently designed for use on humans, which they say could also be used on RNA containing viruses and bacteria.

The developers have used their parallel-screening technique to create optimal guide RNAs for the SARS-CoV-2 coronavirus COVID-19 which could be used for future detection and therapeutic applications. These have been made available online here.

the seed regions could be used as next-generation biosensors, able to precisely discriminate between closely related RNA species

The CRISPR RNA screening technology was developed by researchers in the lab of study senior author Dr Neville Sanjana at the New York Genome Center and at New York University, both US. The platform is optimised to run massively-parallel genetic screens at the RNA level in human cells because it is based on the CRISPR-Cas13 enzyme, which targets RNA instead of DNA. According to the researchers, it could be used to understand aspects of RNA regulation and identify the function of non-coding RNAs in humans.

The team have used the data they collected by targeting thousands of different sites in human RNA transcripts to create a machine learning-based predictive model to expedite identification of the most effective Cas13 guide RNAs. This technology is available to researchers through a website and open-source toolbox, both can predict guide RNA efficiencies for custom RNA targets and provide pre-designed guide RNAs for all human protein-coding genes.

We anticipate that RNA-targeting Cas13 enzymes will have a large impact on molecular biology and medical applications, yet little is known about guide RNA design for high targeting efficacy, said Dr Sanjana. We set about to change that through an in-depth and systematic study to develop key principles and predictive modelling for most effective guide design.

Dr Hans-Hermann Wessels and PhD student Alejandro Mndez-Mancilla, co-first authors of the study published in Nature Biotechnology, developed a suite of Cas13-based tools and conducted a transcript tiling and permutation screen in mammalian cells. In total, they gathered information for more than 24,000 RNA-targeting guides.

We tiled guide RNAs across many different transcripts, including several human genes where we could easily measure transcript knock-down via antibody staining and flow cytometry, said Dr Wessels. Along the way, we uncovered some interesting biological insights that may expand the application of RNA-targeting Cas13 enzymes. These insights included which regions of the guide RNA are important for recognition of a target RNA, calling the identified segments seed regions these are vital for designing guide RNAs with off-target activity on unintended target RNAs.

The scientists suggest that the seed regions could be used as next-generation biosensors, able to precisely discriminate between closely related RNA species.

We are particularly excited to use the optimised Cas13 screening system to target non-coding RNAs. This greatly expands the CRISPR toolbox for forward genetic and transcriptomic screens, concluded Mndez-Mancilla.

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CRISPR RNA-targeted genetic screen could be used for COVID-19 therapy - Drug Target Review

Recommendation and review posted by Bethany Smith

Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain – Science Advances

A genome editing technique based on the clustered regularly interspaced short palindromic repeats (CRISPR)associated endonuclease Cas9 enables efficient modification of genes in various cell types, including neurons. However, neuronal ensembles even in the same brain region are not anatomically or functionally uniform but divide into distinct subpopulations. Such heterogeneity requires gene editing in specific neuronal populations. We developed a CRISPR-SaCas9 systembased technique, and its combined application with anterograde/retrograde AAV vectors and activity-dependent cell-labeling techniques achieved projection- and function-specific gene editing in the rat brain. As a proof-of-principle application, we knocked down the cbp (CREB-binding protein), a sample target gene, in specific neuronal subpopulations in the medial prefrontal cortex, and demonstrated the significance of the projection- and function-specific CRISPR-SaCas9 system in revealing neuronal and circuit basis of memory. The high efficiency and specificity of our projection- and function-specific CRISPR-SaCas9 system could be widely applied in neural circuitry studies.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain - Science Advances

Recommendation and review posted by Bethany Smith

Review: Human Nature hits home in the age of coronavirus – Los Angeles Times

Some days, the miracles of biotech and gene therapy feel like Brave New World is around the corner, and other days like these very days their promise and power cant come fast enough. The cloud of viral uncertainty were currently in makes Adam Bolts science documentary Human Nature an intriguing, mind-tingling watch as it tells the underreported story of CRISPR, the microorganism molecular system discovered in the 1980s, which revealed to the scientific world that DNA the building blocks of our lives can be targeted, snipped and repaired.

Viruses can then be located and stopped, and something like sickle cell can be eradicated, but also if ones imagination is invoked, money is deployed and subjects are willing humans can be designed and cultivated like an attractive, pest-resistant crop. Bolts ethically engaging, easy-to-grasp and artfully conceived film covers a wide range of areas that stir us to think about benefits and costs.

His brainy interviewees from CRISPRs early discoverers and champions to the smiling entrepreneurs ready to help fix our aging, diseased bodies are a personality-rich bunch whose recognition of how significant this is for future generations is presented with wonder, humor and sometimes a welcome pause.

Theres plenty of What have we done? and Wow, what could we do? to go around in Human Nature, which makes for a health swirl of amazement and caution. But as the world tries to right itself from the spread of an unseen global threat, it may very well be the amazement in Bolts film that viewers cling to most.

'Human Nature'

Running time: 1 hour, 34 minutes

Playing: VOD and digital

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Review: Human Nature hits home in the age of coronavirus - Los Angeles Times

Recommendation and review posted by Bethany Smith


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