Opinion: Three-Parent Babies Are an Ethical Choice

Posted: February 27, 2014 at 9:42 am

Perhaps the biggest fear raised by advances in genetic engineering like the ability to create a baby with three parents is that we are heading straight down a road that leads to eugenics the attempt to create perfect "designer" babies.

From "Star Trek" to "Star Wars" to many more films like "Gattaca" and "The Boys from Brazil," Hollywood has warned us time and again that genetic engineering of animals or people is nothing but bad news.

History sadly also shows the horror that eugenics programs have produced in Germany, Japan and many other nations when some people are deemed more desirable and others are seen as defective, burdensome or subhuman. Death camps, forced sterilization, restrictions on marriage, exile, concentration camps, prohibitions on immigration all have all been carried out in the name of eugenics.

But Hollywood is wrong. Not everything about genetic engineering is morally horrible. Nor is human genetic engineering always motivated by eugenic goals.

"Hollywood is wrong. Not everything about genetic engineering is morally horrible."

The FDA is considering approving an experiment to repair a genetic disease in humans by creating embryos with DNA from three parents. Genes would be transferred from a healthy human egg to one that has a disease and the "repaired" egg then fertilized in the hope that a healthy baby will result. The goal of the experiment in genetic engineering is not a perfect baby but a healthy baby.

One in 4,000 children inherit terrible diseases due to genetic mutations in their mitochondria. The mitochondria are the batteries of cells. They provide the energy that lets cells divide and grow. All mitochondria are inherited from the mother from her eggs. And, the mitochondria are separate, tiny units in the egg meaning you can pick them out and transplant them.

So if you know that a mitochondrial disease runs in your family, you might want to try getting pregnant using one of your eggs that has been genetically engineered to have mitochondria from a donor egg.

None of this should raise concerns about abortion. Only eggs, not embryos, would be involved. There are, however, safety concerns. We won't really know if mitochondrial transplants work until healthy young people exist who have been made using the technique. Studies in primates look promising but safety in humans is still a risk.

"How far we go in engineering future generations through genetic manipulations is up to us."

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Opinion: Three-Parent Babies Are an Ethical Choice

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