Genetic link to laziness found in rats

Posted: April 9, 2013 at 1:42 am

09 April 2013| last updated at 10:52AM

"We have shown that it is possible to be genetically predisposed to being lazy," China's Xinhua news agency quoted study author Frank Booth, a professor from the Department of Physiology, School of Medicine, as saying.

"This could be an important step in identifying additional causes forobesity in humans," Booth said.

Booth and his fellow Michael Roberts were able to selectively breed rats that exhibited traits of either extreme activity or extreme laziness.

These rats indicate that genetics could play a role in exercise motivation, even in humans, according to the study published in the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.

"It would be very useful to know if a person is genetically predisposedto having a lack of motivation to exercise, because that could potentially makethem more likely to grow obese," said Booth.

Booth put rats in cages with running wheels and measured how much each rat willingly ran on their wheels during a six-day period.

They then bred the top 26 runners with each other and bred the 26 rats thatran the least with each other.

They repeated this process through 10 generations and found that the line of running rats chose to run 10 times more than the line of "lazy" rats.

Once the researchers created their "super runner" and "couch potato"rats, they studied the levels of mitochondria in muscle cells, compared body composition and conducted thorough genetic evaluations through RNA deep sequencing of each rat.

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Genetic link to laziness found in rats

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