Gene Associated With Post Traumatic Stress Disorder Found By Boston Researchers

Posted: August 10, 2012 at 7:16 am

Editor's Choice Main Category: Anxiety / Stress Also Included In: Genetics;Mental Health;Psychology / Psychiatry Article Date: 09 Aug 2012 - 12:00 PDT

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PTSD is a psychiatric disorder that is characterized by serious changes in behavioral, cognitive, emotional and psychological functioning after experiencing a psychologically traumatic event. According to earlier research, around 8% of the U.S. population will develop PTSD at some time in their life. This figure is considerably higher amongst veterans, with as many as 1 in 5 veterans suffering from PTSD. Earlier genome wide-association studies (GWAS) have associated the RORA gene to other psychiatric conditions, such as bipolar disorder, attention-deficit hyperactivity disorder, depression and autism.

Leading researcher Mark W. Miller, PhD, associate professor at BUSM and a clinical research psychologist in the National Center for PTSD at VA Boston Healthcare System said:

The study involved around 500 male and female veterans and their intimate partners, who had all experienced trauma, whilst around half of the participants experienced PTSD. Most of the veterans suffered trauma during their military experience, whilst their intimate partners had experienced trauma through experiences like physical or sexual assault, serious accidents, or the sudden death of a loved one.

Following an interview with a trained clinician, each participant agreed to donate their DNA from a blood sample, which was subsequently analyzed for around 1.5 million genetic markers with regard to signs of links with PTSD. The findings revealed a highly important link with a variant (rs8042149) in the RORA gene.

The researchers subsequently used data from the Detroit Neighborhood Health Study to look for evidence of replication and also discovered a considerable but weaker link between PTSD and RORA.

Miller concluded:

Written by Petra Rattue Copyright: Medical News Today Not to be reproduced without permission of Medical News Today

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Gene Associated With Post Traumatic Stress Disorder Found By Boston Researchers

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