Archive for the ‘Skin Stem Cells’ Category

NEW YORK, Oct. 22, 2019 /PRNewswire/ -- Bloomberg Philanthropies, Johns Hopkins University School of Medicine (JHUSOM), and The New York Stem Cell Foundation (NYSCF) Research Institute today announced an initiative to fundamentally advance and expand the science of precision medicine, in which diagnostic disease markers are defined with pinpoint accuracy to help researchers understand disease pathways and customize therapeutic approaches. The collaboration will combine the renowned clinical and medical expertise of Johns Hopkins with the unique stem cell technologies and research capabilities of the NYSCF Research Institute to accelerate Hopkins' pioneering Precision Medicine Initiatives.

"Johns Hopkins is working intensively to realize the great promise of precision medicine for all those in our care, locally and globally," said Johns Hopkins President Ronald J. Daniels. "This significant new collaboration with Bloomberg Philanthropies and NYSCF moves us ever closer to that aim as we join together our far-reaching research capacities to advance knowledge and deliver better health outcomes for populations and people around the world."

This collaboration will also establish an unprecedented cache of human disease models available to researchers worldwide thus promoting the real world application of precision medicine and driving a new paradigm for understanding and improving the approach to human disease.

"Bloomberg Philanthropies' mission is to ensure better, longer lives for the greatest number of people," said Michael R. Bloomberg, founder of Bloomberg LP and Bloomberg Philanthropies. "For years, Johns Hopkins University and the New York Stem Cell Foundation have shared that mission and we're honored to deepen our partnerships with them as they explore new, innovative ways to save lives through the application of precision medicine."

Diseases manifest themselves differently in different patients. To understand the basis of these differences and to tailor treatments for specific patients, researchers need more accurate biological tools. Stem cell models provide a "biological avatar" of the patient from which they were created, allowing scientists and clinicians to better understand, define, and account for differences in individual patients and groups of patients.

The new initiative will use induced pluripotent stem cells to study disease characteristics in subgroups of patients, identifying markers that lead to varying disease manifestations. For example, by examining stem cells from seemingly similar patients with different forms of multiple sclerosis, we may be able to better understand the full range of disease mechanisms and pathways.

The Johns Hopkins Precision Medicine Initiative already includes 16 Precision Medicine Centers of Excellence (PMCOE), each focusing on a specific disease, and is now working to develop 50 Precision Medicine Centers in the next five years. Johns Hopkins believes that this advancement in the study and application of precision medicine has the potential to transform the diagnosis and management of many diseases.Often, what is now categorized as a single disease is actually made up ofmultiple diseases that display similar symptoms, but require quite different therapies. Using a wide range of data sources, precision medicine seeks to better elucidate these differences, so that doctors can treat patients with precisely targeted therapies. At Johns Hopkins, dozens of researchers are bringing this idea to reality across a spectrum of debilitating and life-altering diseases.

In this collaboration, the process will begin with the full consent of patients in JHUSOM PMCOEs who wish to participate. Biological samples from the JHUSOM PMCOEs will be collected by the NYSCF Research Institute where scientists will create stem cell models of disease using the NYSCF Global Stem Cell Array, the world's first end-to-end automated system for generating human stem cells in a parallel, highly controlled process.Integrating robotics and machine learning, NYSCF's technology reprograms skin or blood cells into stem cells, differentiates them into disease-relevant cell types, and performs genome editing to unravel the genetic basis of disease.

"The NYSCF Research Institute has invented and scaled the most advanced methods of human cell manipulation, which is critical for studying disease at the level of the individual patient," explained NYSCF CEO Susan L. Solomon. "By combining our capabilities with Johns Hopkins' extensive clinical data and expertise, we will be able to develop effective, personalized therapies for patients suffering from diseases with a high unmet need."

The stem cells generated by NYSCF will be used to research and drive effective therapeutic and diagnostic development in a wide range of diseases that include, but are not limited to, Multiple Sclerosis, Alzheimer's, chronic renal failure, and cancers of the lung, breast, prostate, pancreas, and bladder. These stem cell lines will reside in the NYSCF Repository and serve as an extraordinary resource in perpetuity for the disease research community. This vast collection will allow scientists unprecedented insights into the biochemical and genetic mechanisms underlying different diseases and subtypes thereof, thereby illuminating avenues for effective, tailored interventions.

"Stem cell science holds enormous potential for the treatment of a wide range of diseases," said Paul B. Rothman, dean of the School of Medicine and CEO of Johns Hopkins Medicine. "By combining this approach with Johns Hopkins' groundbreaking work on precision medicine, we are creating a scientific powerhouse that will help us advance medicine and science at an even faster pace. I am excited to see the discoveries and innovations that will be produced by this collaboration."

About Bloomberg PhilanthropiesBloomberg Philanthropies invests in 510 cities and 129 countries around the world to ensure better, longer lives for the greatest number of people. The organization focuses on five key areas for creating lasting change: Arts, Education, Environment, Government Innovation, and Public Health. Bloomberg Philanthropies encompasses all of Michael R. Bloomberg's giving, including his foundation and personal philanthropy as well as Bloomberg Associates, a pro bono consultancy that works in cities around the world. In 2018, Bloomberg Philanthropies distributed $767 million. For more information, please visitbloomberg.orgor follow us on Facebook, Instagram, YouTube, and Twitter.

About The New York Stem Cell Foundation Research Institute The New York Stem Cell Foundation (NYSCF) Research Institute is an independent non-profit organization accelerating cures and better treatments for patients through stem cell research. The NYSCF global community includes over 180 researchers at leading institutions worldwide, including the NYSCF Druckenmiller Fellows, the NYSCF Robertson Investigators, the NYSCF Robertson Stem Cell Prize Recipients, and NYSCF Research Institute scientists and engineers. The NYSCF Research Institute is an acknowledged world leader in stem cell research and in developing pioneering stem cell technologies, including the NYSCF Global Stem Cell Array and in manufacturing stem cells for scientists around the globe. NYSCF focuses on translational research in an accelerator model designed to overcome barriers that slow discovery and replace silos with collaboration. For more information, visit http://www.nyscf.org or follow us on Twitter, Facebook, and Instagram.

Press Contacts:

The New York Stem Cell Foundation Research Institute David McKeon dmckeon@nyscf.org 212-365-7440

Johns Hopkins University School of Medicine Vanessa Wasta wasta@jhmi.edu

SOURCE The New York Stem Cell Foundation

Home

The rest is here:
Bloomberg Philanthropies, Johns Hopkins University School of Medicine, and The New York Stem Cell Foundation Research Institute Announce an...

The worlds first cell atlas of the human developmental liver has been created, giving fresh insight into how the blood and immune systems develop in the foetus.

A high-resolution resource, it will aid our understanding of normal development and efforts to tackle diseases that can form during development, such as leukaemia and immune disorders.

The cell atlas maps how the cellular landscape within the developing liver changes between the first and second trimesters of pregnancy, including how stem cell from the liver seed other tissues, supporting the high demand for oxygen required for growth.

Researchers from the Wellcome Sanger Institute in Hinxton, the Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Newcastle University and their collaborators created the atlas by using single cell technology to analyse 140,000 liver cells and 74,000 skin, kidney and yolk sac cells.

In adults, it is bone marrow that is primarily responsible for the creation of blood and immune cells in a process called haematopoiesis.

In early embryonic life, the yolk sac and liver play a key role in creating these cells, which then seed peripheral tissues such as skin, kidney and ultimately bone marrow.

But until now, the precise process of how blood and immune systems develop in humans has been unknown.

Isolating cells from the developing liver, the researchers were able to identify them by what genes they were expressing and discover what the cells looked like.

They tagged haematopoietic cells in sections of developmental liver using heavy metal markers in order to map them to their location.

Prof Muzlifah Haniffa, a senior author of the study from Newcastle University and senior clinical fellow at the Wellcome Sanger Institute, said: Until now research in this area has been a little bit like blindfolded people studying an elephant, with each describing just a small part of it.

This is the first time that anyone has described the whole picture, how the blood and immune systems develop in such detail. Its been an extraordinary, multidisciplinary effort that is now available as a tool for the whole scientific community.

The scientists learned that during foetal development, mother haematopoietic stem cells stay in the liver. But the liver alone cannot supply enough red blood cells, so the next generation daughter cells called progenitor cells travel to other tissues, maturing in places such as the skin. Thee, they develop into red blood cells to help meet the high demand for oxygen in the developing foetus.

Dr Elisa Laurenti, a senior author from the Wellcome MRC Cambridge Stem Cell Institute and the Department of Haematology at the University of Cambridge, said: We knew that as adults age our immune system changes. This study shows how the livers ability to make blood and immune cells changes in a very short space of time, even between seven and 17 weeks post-conception.

If we can understand what makes the stem cells in the liver so good at making red blood cells, it will have important implications for regenerative medicine.

The study, published in Nature, also involved the mapping of genes involved in immune deficiencies to reveal which cells were expressing them.

It is known that gene mutations can lead to immune disorders such as leukaemia.

A better understanding of the development of healthy liver functions could aid our understanding of how to treat such conditions.

The work is part of the ambitious effort to create the first complete Human Cell Atlas.

Dr Katrina Gold, genetics and molecular sciences portfolio manager at Wellcome, said: Our immune system is vital in helping to protect us from disease, yet we know very little about how immune cells develop and behave in the early embryo. This study is hugely important, laying a critical foundation for future research that could help improve our understanding of disorders linked to the early immune system, such as childhood leukaemias.

The Human Cell Atlas has the potential to transform our understanding of health and disease and were excited to see these first discoveries from our Wellcome-funded multidisciplinary team of scientists.

Dr Sarah Teichmann, a senior author from the Wellcome Sanger Institute, University of Cambridge and co-chair of the Human Cell Atlas organising committee, said: The first comprehensive cellular map of the developmental liver is another milestone for the Human

Cell Atlas initiative.

The data is now freely available for anyone to use and will be a great resource to better understand healthy cellular development and disease-causing genetic mutations.

Read more

Asthma treatment hope as Human Cell Atlas project creates first map of lungs

Sanger Institute scientist helps unveil blueprint for extraordinary Human Cell Atlas

AstraZeneca and Cancer Research UK launch joint Functional Genomics Centre in Cambridge

More here:
Worlds first cell atlas of developing liver created by Cambridge scientists - Cambridge Independent

Non-surgical regenerative cell-based treatment uses the bodys natural healing ability to repair damaged bones, muscles, cartilage, tendons and ligaments.Knee injuries are painful and often patients are unable to walk. Our treatment protocol always uses products following FDA guidelines.Injections done with ultrasound guided needle recognition capability to ensure safety as well target the area needing treatment. Plasma; Alpha-2-Macroglobulim (A2M) is the new biologic treatment for your arthritic knee (osteoarthritis)When your hips hurt, or your knee is stiff, or your back is throbbing, that means your joint is bone on bone and there is no lubrication to ease movement.Regenerative medicine giving new hope to patients suffering from painful joint injuries such as knee, shoulder and hip with a chance to live a pain free life.Regenerative cell-based ultrasound guided injection now available to treat pain associated with joint injury. There are indications that it reduces the pain and swelling of the joints and helps lubricating and improve movements.Commonly Treated Conditions: Osteoarthritis of the Hips, Knee, and Shoulders Rotator Cuff tears of the Shoulder Meniscus, ACL and PCL tears of the kneeOur stem cell treatment using your own stem cells and with using imaging guidance ensures precise injection of stem cell, it is a highly-specialized practice.Besides treating above injuries we have advance stem cell micro-needling treatment for the following: Cell-based PRP Hair Restoration combining micro-needling with growth factors and hair follicles voluma vitamins plus BLotinyl T1, Biotin, Anti-aging and Kopexil. Non-toxin facial renewal Anti-Aging APGF Advanced Peptide Micro-needling PRP, Dual Anti-Aging Ampoules for deep hydration, more collagen to reduce wrinkles and firm skin.Dr. Ibrahim is the staff physician at Valencia Medical Center specializing in regenerative medicine, pain management, and rejuvenation. Call for a consultation at 661-222-9117.

More:
Hormones Control your Health, Mood and Behavior A balanced hormone means happier, healthier life and success in career and relationship. - Magazine of...

New report on Regenerative Medicine Market 2019 focuses on the growth opportunities, which will help the Regenerative Medicine market to expand operations in the existing markets. Regenerative Medicine market research study is significant for manufacturers in the Regenerative Medicine market, including industry stakeholders, distributors, suppliers, and investors, and it can also help them understand applicable strategies to grow in the Regenerative Medicine market.

In Regenerative Medicine Market Report, Following Companies Are Covered:

Get a Sample Copy of the Report https://www.industryresearch.co/enquiry/request-sample/14244620

Market Overview:

Scope of the Report:

Regenerative Medicine Market Report Provides Comprehensive Analysis of:

For More Information or Query or Customization Before Buying, Visit at https://www.industryresearch.co/enquiry/pre-order-enquiry/14244620

Key Market Trends:

Dermatology is the Segment by Application that is Expected to be the Largest During the Forecast Period

Dermatology is estimated to have the largest share in revenue generation, and this high contribution is attributive to the presence of easy grafting techniques for dermatological wounds and diseases. Skin, being an organ with great cell replication characteristics, provides various types of stem cells from its different layers. Therefore, there are a broad range of products present, from patches to cure small injuries to matrix and grafts for chronic wounds and burns. Thus, the segment is expected to continue to dominate the market through to the forecast period.

The increasing number of accidents and bone defects is also expected to drive the regenerative medicine market. There are also several research studies that are being conducted on tissue engineering for the development of bone graft substitutes, with the help of regenerative medicine. So, with the new advances in bone graft, the market is expected to grow over the forecast period.

North America Holds the Largest Share and is Expected to Follow the Same Trend Over the Forecast Period

North America is estimated to have the largest share, in terms of revenue, owing to the presence of major players and rapid advances in technology, along with high investments in stem cell and oncology research. There is also an increasing prevalence of diseases, such as cancer and diabetes, which can now be cured by various stem cell therapies. Additionally, the awareness regarding the available stem cell procedures and therapies among people is rising, which in turn, is increasing the demand for the overall market.

Reasons for Buying Regenerative Medicine Market Report:

Purchase this Report (Price 4250 USD for single user license) https://www.industryresearch.co/purchase/14244620

Detailed TOC of Regenerative Medicine Market Report 2019-2024:

1 INTRODUCTION1.1 Study Deliverables1.2 Study Assumptions1.3 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS4.1 Market Overview4.2 Market Drivers4.2.1 Increasing Adoption of Stem Cell Technology4.2.2 Technological Advancements in Regenerative Medicine4.3 Market Restraints4.3.1 Regulatory and Ethical Issues4.3.2 High Cost of Treatments4.4 Porters Five Forces Analysis4.4.1 Threat of New Entrants4.4.2 Bargaining Power of Buyers/Consumers4.4.3 Bargaining Power of Suppliers4.4.4 Threat of Substitute Products4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION5.1 By Type of Technology5.1.1 Stem Cell Therapy5.1.2 Biomaterial5.1.3 Tissue Engineering5.1.4 Other Types of Technologies5.2 By Application5.2.1 Bone Graft Substitutes5.2.2 Osteoarticular Diseases5.2.3 Dermatology5.2.4 Cardiovascular5.2.5 Central Nervous System5.2.6 Other Applications5.3 Geography5.3.1 North America5.3.1.1 United States5.3.1.2 Canada5.3.1.3 Mexico5.3.2 Europe5.3.2.1 Germany5.3.2.2 United Kingdom5.3.2.3 France5.3.2.4 Italy5.3.2.5 Spain5.3.2.6 Rest of Europe5.3.3 Asia-Pacific5.3.3.1 China5.3.3.2 Japan5.3.3.3 India5.3.3.4 Australia5.3.3.5 South Korea5.3.3.6 Rest of Asia-Pacific5.3.4 Middle East & Africa5.3.4.1 GCC5.3.4.2 South Africa5.3.4.3 Rest of Middle East & Africa5.3.5 South America5.3.5.1 Brazil5.3.5.2 Argentina5.3.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE6.1 Company Profiles6.1.1 Allergan6.1.2 Osiris Therapeutics6.1.3 Integra Lifesciences6.1.4 Cook Biotech Incorporated6.1.5 Organogenesis Inc.6.1.6 Baxter6.1.7 Medtronic6.1.8 Thermo Fisher Scientific6.1.9 Sigma-Aldrich Co.6.1.10 Becton Dickinson and Company

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

Contact Us:

Name: Ajay More

Phone: US +14242530807/ UK +44 20 3239 8187

Email: [emailprotected]

Our Other Reports:

Global Fork Sensors Market 2019-2025 Estimated Size, Share, Emerging Technologies, Professional Outlook, Regional Segmentation by Type and Applications

Motor Vehicle Speakers Market 2019 | Top Leading Countries with Industry Size, Companies, Consumption, Drivers, Trends, Forces Analysis, Revenue, Challenges and Global Forecast 2023

Cable Assembly Market 2019: Production and Consumption Value, Import and Export Data with Forecast 2024

Global Modular Building Market Size 2019: Research Methodology, Top Manufactures and Market Size Estimate 2025

More here:
Regenerative Medicine Market 2019 | Remarkable Growth Factors with Industry Size & Share, New Innovations of Leading Players & Forecast till...

Would you live in a city without streets? Or in a flat with no walls? Probably not and the cells in our bodies expect the same level of comfort. Today, were taking a look at the tissues that create and maintain an ideal working environment for our tissues: the extracellular matrix.

Weve had a look at the differences between animal and plant cells before (heres a refresher). One of the key differences between them is that plants reinforce their cells with thick, sturdy walls. These walls are why plant tissues such as wood can get so resilient. However, the reverse of the coin is that it also limits plant cells somewhat: a muscle made out of wood wouldnt be very effective.

Animals need cells that can perform a wide variety of activities, but these cells also need biological and mechanical support to perform their tasks. Thats where the extracellular matrix, or ECM, comes in.

The ECM is a complex mix of proteins and carbohydrates that fills the spaces between cells; it is comprised of the basement membrane and interstitial matrix. Going forward, Ill use the term ECM quite loosely to mean both the extracellular matrix and the interstitial matrix. If I dont mention the basement membrane specifically, Im probably talking about the interstitial matrix (as its the more dynamic and frankly more interesting half of the topic).

Think of the basement membrane as a sheet of plastic wrap the body stretches over every individual tissue or organ to keep everything tidy and in place. This membrane is made up of two layers of cells and its quite fibrous and hard to rip.

The interstitial matrix is, for lack of a better term, the goo that our cells live in. Most of the time, it looks and feels a bit like a clear gel. Its produced by the cells themselves, which secrete and release certain compounds around them.

The simplest definition of the extracellular matrix is that it represents the sum of non-cellular components present within all tissues and organs. As we go forward, keep in mind that the ECM isnt the same everywhere.

Although, fundamentally, the ECM is composed of water, proteins, and polysaccharides, each tissue has an ECM with a unique composition and topology that is generated during tissue development, Christian Frantz, Kathleen M. Stewart, Valerie M. Weaver, 2010.

Collagen, the most abundant protein in mammals, is the main component of the ECM. Outside the cell, collagen binds with carbohydrate molecules and assembles into long molecules called collagen fibrils. These fibrils extend through the ECM and lend flexibility and strength to the material, acting similarly to the role of rebar in reinforcing concrete (which is tough but inflexible). Collagen fibrils are flexible and tough to break, so theyre used to bind together the rest of the ECM. In humans, genetic disorders that affect collagen (such as Ehlers-Danlos syndrome) cause tissues to become fragile and tear easily.

While the ECM contains a wide range of proteins and carbohydrates, another important set of compounds alongside collagen are proteoglycans (groups of proteins tied to simple sugars). Proteoglycans come with many shapes and functions, depending on which proteins and sugars theyre made of, and perform a wide range of tasks in the ECM. They can also bind to each other, to collagen (forming cartilage), or to hyaluronic acid, making them even more versatile. As a rule of thumb, proteoglycans act as fillers and regulate the movement of molecules through the ECM among other functions.

Their overall structure looks like a tree: the sugar part of the polyglycans are twigs set on a branch (the protein), which ties to a trunk made out of polysaccharide (many-sugar) molecules. A class of proteins in the membranes of cells, called integrins, serve as connection ports between the membrane and material in the ECM (such as collagen fibers and proteoglycan-polysaccharide bundles). Beneath the membrane, integrins tie into the cells support girders (the cytoskeleton).

The type of ECM Ive described so far is your run of the mill variety that youll find in skin, around muscle fibers, in adipose tissue (fat), and so on. But each tissue has an ECM that fully supports its function blood plasma is the interstitial matrix of blood. Unlike the ECM of muscles, for example, which is meant to reduce friction and wear in the tissue, blood plasma primarily works as a medium to carry blood cells around. Blood vessels are coated with a basement membrane, and together, they form the ECM of blood. Each type of animal connective tissue has its own type of ECM, even bone.

Seeing as there are many types of ECM out there, it stands to reason that there are many functions they perform. However, by and large, there are a few functions that all ECMs fulfill.

The first and perhaps most important function is that they provide support to tissues, segregate (separate) them, and that they mediate intercellular communication. The ECM is also what regulates a cells dynamic behavior i.e. whether a cell moves around, and how. The ECM keeps cells in place so we dont simply unravel. The connections formed between the ECM and integrins on a cells membrane also function as signaling pathways.

It is also essential for the good functioning of tissues at large. The ECM creates and maintains the proper environmental conditions for cells to develop, multiply, and form functioning tissues. While the exact details are still unknown, the ECM has been found to cause tissue regrowth and healing after injury. In human fetuses, for example, the extracellular matrix works with stem cells to grow and regrow all parts of the human body. Fetuses can regrow anything that gets damaged in the womb, but since babies cant, we suspect that the matrix loses this function after full development. Researchers are looking into applying it for tissue regeneration in adults.

The ECM can also act as a storage space for various compounds. In joints, it contains more hyaluronic acid which in turn absorbs water and acts as a mechanical cushion. ECMs can also store a wide range of cellular growth factors and release them as needed. This allows our bodies to activate cell growth on a dime when needed without having to produce and ship these factors to a certain area.

It also seems to impact cell differentiation and gene expression. Cells can switch genes on or off depending on the elasticity of the ECM around them. Cells also seem to want to migrate towards stiffer areas of the ECM generally (durotaxis) from less-firm ones.

The ECM isnt very well known today, and it definitely goes unsung. But no matter how you cut it, it is a key part of biology as we know it today. Without it, both animals and plants would be formless, messy blobs quite literally. And I dont know about you but I love it when my tissues stay where theyre supposed to, the way theyre supposed to.

Continued here:
The extracellular matrix, and how it keeps you in tip top shape - ZME Science

PENCOED, Wales, Oct. 23, 2019 /PRNewswire/ --ReNeuron Group plc (AIM: RENE), a UK-based global leader in the development of cell-based therapeutics, is pleased to announce that new data relating to its CTX stem cell platform will be presented today at the 27th Annual Congress of the European Society of Gene and Cell Therapy(ESGCT), a leading scientific conference taking place this week in Barcelona, Spain.

Dr. Steve Pells, Principal Investigator at ReNeuron, will present new data showing the phenotypic stability and scalability of a mesenchymal stem cell line derived from the Company's proprietary, conditionally immortalized, human neural stem cell line (CTX) following re-programming to a pluripotent state.

The Company has previously presented data demonstrating that its CTX stem cell line, currently undergoing clinical evaluation for the treatment of stroke disability, can be successfully and rapidly re-programmed to an embryonic stem cell-like state enabling differentiation into any cell type. In essence, this means that the Company is able to take its neural stem cells back to being stem cells that can be made to develop into any other type of stem cell including bone, nerve, muscle and skin.

The new data being presented today show for the first time that these CTX-iPSCs (induced pluripotent stem cells) can indeed be differentiated along different cell lineages to generate, for example, mesenchymal stem cell lines. Further, the mesenchymal stem cell lines generated can be grown at scale by virtue of the Company's conditional immortalization technology, enabling the efficient production of clinical-grade cell therapy candidates.

These results are particularly encouraging as they demonstrate that CTX, a well-characterized, clinical-grade neural stem cell line, could be used to produce new conditionally immortalized allogeneic (i.e. non-donor-specific) cell lines from any of the three primary germ cell layers which form during embryonic development. ReNeuron is currently exploring the potential to develop further new allogeneic cell lines as potential therapeutic agents in diseases of unmet medical need for subsequent licensing to third parties.

Further information about the conference may be found at:

https://www.esgct.eu/congress/barcelona-2019.aspx

"The data we are presenting at the ESGCT Annual Congress represent a significant advance in the use of cell re-programming to generate new allogeneic cell lines as potential therapeutic candidates," commented Dr. Randolph Corteling, Head of Research at ReNeuron. "Importantly, the maintenance of the immortalization technology within these new cell lines may allow for the scaled production of 'off the shelf' allogeneic stem cells, such as haematopoietic stem cells as a potential alternative approach to those cancer immunotherapies currently in development that rely on the use of the patient's own T-cells."

About ReNeuronReNeuron is a global leader in cell-based therapeutics, harnessing its unique stem cell technologies to develop 'off the shelf' stem cell treatments, without the need for immunosuppressive drugs. The Company's lead clinical-stage candidates are in development for the blindness-causing disease, retinitis pigmentosa, and for disability as a result of stroke. ReNeuron is also advancing its proprietary exosome technology platform as a potential delivery system for drugs that would otherwise be unable to reach their site of action. ReNeuron's shares are traded on the London AIM market under the symbol RENE.L. For further information visit http://www.reneuron.com.

ENQUIRIES:

ReNeuron

+44 (0)20 3819 8400

Olav Helleb, Chief Executive Officer

Michael Hunt, Chief Financial Officer

Buchanan (UK)

+44 (0) 20 7466 5000

Mark Court, Tilly Abraham

Argot Partners (US)

Stephanie Marks, Claudia Styslinger

Stifel Nicolaus Europe Limited

+1 212 600 1902

+44 (0) 20 7710 7600

Jonathan Senior, Stewart Wallace, Ben Maddison (NOMAD and Joint Broker)

N+1 Singer

+44 (0) 20 7496 3000

Aubrey Powell, James Moat, Mia Gardner

(Joint Broker)

SOURCE ReNeuron Group plc

Home

See the article here:
ReNeuron Presents Positive Data at the 27th Annual Congress of the European Society of Gene and Cell Therapy on Lead Cell Line - PRNewswire

Stem Cell Therapy Market: Snapshot

Of late, there has been an increasing awareness regarding the therapeutic potential of stem cells for management of diseases which is boosting the growth of the stem cell therapy market. The development of advanced genome based cell analysis techniques, identification of new stem cell lines, increasing investments in research and development as well as infrastructure development for the processing and banking of stem cell are encouraging the growth of the global stem cell therapy market.

Order Brochure for more Detailed Information @https://www.tmrresearch.com/sample/sample?flag=B&rep_id=1787

One of the key factors boosting the growth of this market is the limitations of traditional organ transplantation such as the risk of infection, rejection, and immunosuppression risk. Another drawback of conventional organ transplantation is that doctors have to depend on organ donors completely. All these issues can be eliminated, by the application of stem cell therapy. Another factor which is helping the growth in this market is the growing pipeline and development of drugs for emerging applications. Increased research studies aiming to widen the scope of stem cell will also fuel the growth of the market. Scientists are constantly engaged in trying to find out novel methods for creating human stem cells in response to the growing demand for stem cell production to be used for disease management.

It is estimated that the dermatology application will contribute significantly the growth of the global stem cell therapy market. This is because stem cell therapy can help decrease the after effects of general treatments for burns such as infections, scars, and adhesion. The increasing number of patients suffering from diabetes and growing cases of trauma surgery will fuel the adoption of stem cell therapy in the dermatology segment.

Global Stem Cell Therapy Market: Overview

Also called regenerative medicine, stem cell therapy encourages the reparative response of damaged, diseased, or dysfunctional tissue via the use of stem cells and their derivatives. Replacing the practice of organ transplantations, stem cell therapies have eliminated the dependence on availability of donors. Bone marrow transplant is perhaps the most commonly employed stem cell therapy.

Osteoarthritis, cerebral palsy, heart failure, multiple sclerosis and even hearing loss could be treated using stem cell therapies. Doctors have successfully performed stem cell transplants that significantly aid patients fight cancers such as leukemia and other blood-related diseases.

Request TOC for Facts & Tables @https://www.tmrresearch.com/sample/sample?flag=T&rep_id=1787

Global Stem Cell Therapy Market: Key Trends

The key factors influencing the growth of the global stem cell therapy market are increasing funds in the development of new stem lines, the advent of advanced genomic procedures used in stem cell analysis, and greater emphasis on human embryonic stem cells. As the traditional organ transplantations are associated with limitations such as infection, rejection, and immunosuppression along with high reliance on organ donors, the demand for stem cell therapy is likely to soar. The growing deployment of stem cells in the treatment of wounds and damaged skin, scarring, and grafts is another prominent catalyst of the market.

On the contrary, inadequate infrastructural facilities coupled with ethical issues related to embryonic stem cells might impede the growth of the market. However, the ongoing research for the manipulation of stem cells from cord blood cells, bone marrow, and skin for the treatment of ailments including cardiovascular and diabetes will open up new doors for the advancement of the market.

Global Stem Cell Therapy Market: Market Potential

A number of new studies, research projects, and development of novel therapies have come forth in the global market for stem cell therapy. Several of these treatments are in the pipeline, while many others have received approvals by regulatory bodies.

In March 2017, Belgian biotech company TiGenix announced that its cardiac stem cell therapy, AlloCSC-01 has successfully reached its phase I/II with positive results. Subsequently, it has been approved by the U.S. FDA. If this therapy is well- received by the market, nearly 1.9 million AMI patients could be treated through this stem cell therapy.

Another significant development is the granting of a patent to Israel-based Kadimastem Ltd. for its novel stem-cell based technology to be used in the treatment of multiple sclerosis (MS) and other similar conditions of the nervous system. The companys technology used for producing supporting cells in the central nervous system, taken from human stem cells such as myelin-producing cells is also covered in the patent.

Global Stem Cell Therapy Market: Regional Outlook

The global market for stem cell therapy can be segmented into Asia Pacific, North America, Latin America, Europe, and the Middle East and Africa. North America emerged as the leading regional market, triggered by the rising incidence of chronic health conditions and government support. Europe also displays significant growth potential, as the benefits of this therapy are increasingly acknowledged.

Asia Pacific is slated for maximum growth, thanks to the massive patient pool, bulk of investments in stem cell therapy projects, and the increasing recognition of growth opportunities in countries such as China, Japan, and India by the leading market players.

Avail the Discount on this Report @https://www.tmrresearch.com/sample/sample?flag=D&rep_id=1787

Global Stem Cell Therapy Market: Competitive Analysis

Several firms are adopting strategies such as mergers and acquisitions, collaborations, and partnerships, apart from product development with a view to attain a strong foothold in the global market for stem cell therapy.

Some of the major companies operating in the global market for stem cell therapy are RTI Surgical, Inc., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc., NuVasive, Inc., Pharmicell Co., Ltd., Anterogen Co., Ltd., JCR Pharmaceuticals Co., Ltd., and Holostem Terapie Avanzate S.r.l.

About TMR Research:

TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in todays supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

Go here to read the rest:
Stem Cell Therapy Market Latest Report with Forecast to 2025 - Health News Office

Turmeric has numerous uses when it comes to health benefits. They are being used in Indian households for a long time.These include several health benefits and medicinal uses. Turmeric is one of the most powerful spices. It has a unique taste with a mix of citrusy bitterness. It is also associated with Ayurvedic practices.

Also read:Indian Food: What Are The Uses Of Turmeric In Indian Dishes?

Turmeric also has some benefits to enhance your beauty. Its anti-inflammatory properties help in removing dead skin cells. It can also be used to wash your fash or apply once in a while. There are several benefits you can receive from turmeric. These are some of the imperative ones.

Also read:Basil Benefits: Top Benefits Of Basil For Your Skin

The anti-inflammatory properties that are found in turmeric are used to soothe osteoarthritis and rheumatoid arthritis. These collectively work in your favour. The antioxidant destroys the free radicals in the body that damage the cells. These can help alleviate and relax your mild joint pains. It cannot be used as a substitute for medication.

There is a compound in turmeric that has not been studied as much as the other compounds like curcumin - aromatic turmerone or ar-turmerone. This compound has reportedly been repairing brain stem cells. It also helps in the recovery from neurodegenerative diseases like stroke and Alzheimer's.

A substance in turmeric Lipopolysaccharide has anti-bacterial, anti-fungal, and anti-viral agents. This also helps to stimulate the immune system. Make sure you consume only a teaspoon in warm water.

Also read:Jackfruit: Delicious Recipes To Make With The Diabetic Friendly Fruit

The anti-inflammatory and antioxidant properties of curcumin help to reduce the onset of Type 2 diabetes. It helps to moderate insulin levels and boosts the effect of medications that treat diabetes. But always remember not to use it as a source of medication.

Turmeric increases the production of vital enzymes that detoxify our blood in the liver by breaking down and reducing the toxins. It also helps with the circulation of blood. Overall, it is known to improve liver health.

Original post:
Turmeric: Uses and benefits of the spice that you must know - Republic World - Republic World

Humans diverged from chimpanzees and other great apes roughly 6m years ago. But despite us being closely related, human brains are vastly different enabling us to engage in complex language, science, art, morality and much more. But what exactly was it that enabled our brains to reach such mindboggling heights?

We know that the human brain has dramatically expanded in size over the past 6m years. Humans are in fact the mammals with the largest brain relative to body size. But which specific evolutionary genetic changes enabled larger and more complex brains has long remained a bit of a mystery. Now a new study, published in Nature, offers clues.

One important reason why it has been so hard to study primate brain development is that, until relatively recently, scientists did not have access to living, developing brain tissue. This is what can ultimately allow us to functionally test theories of brain evolution as we can essentially watch how a brain develops over time in a dish and manipulate biological pathways to see what role they play in brain development.

But in the last few years, scientists have worked out how to make lab-grown models of developing brain tissue so-called brain organoids to begin to address these questions.

Organoids are clusters of cells that organise themselves into mini versions of our organs, such as the brain or the liver. Thats because they are made by culturing stem cells, which have the potential to develop into any tissue of the body. These stem cells can be generated directly from cells of adult origin, such as skin or blood cells. They are then grown in a gel that allows them to develop three dimensionally. And thats exactly what the researchers behind the new study did.

So what kind of genetic changes do we think contributed to human brain evolution? Only about 1.5% of our DNA actually consists of genes with instructions for making proteins. Proteins are the molecules that do most of the work in cells and determine the cells structure and function. It was once thought that the remaining 98.5% of DNA was junk with no clear purpose. However, it is now known that some of this DNA may play an important role in controlling which genes are expressed meaning determining how they are turned on and off.

The number of changes in protein-coding regions of DNA are far too few to explain the striking differences observed between humans and other primates. In fact, of the genetic regions that have changed the most since our divergence from chimpanzees, 92% do not overlap with protein-coding DNA.

It is predicted that at least a third of these regions play a role in controlling the expression of genes. It has long been hypothesised that the majority of differences observed between the brains of great apes and us are due to changes in the timing and expression of genes, rather than changes to the gene itself. The vast majority of our genes are therefore identical.

The main focus of the new study was to identify how genes are regulated differently in humans compared to other primates. The authors did this by generating brain organoids from human, chimpanzee and macaque stem cells and compared these at various points over the course of four months. This mimics how a brain forms in the womb, with organoids consisting of multiple growing buds of brain tissue that first consist largely of neural progenitor cells that in later stages begin to make neurons.

From the outside, brain organoids look more like small popcorn than a mini brain and do not reach sizes larger than around five or six millimetres due to a lack of blood supply.

The authors observed that human brain development occurs at a slower pace than the other two primates. This delayed maturation of the human brain makes sense as, given more time, the cells that generate neurons will have a longer period to expand their population, giving rise to more neurons and a bigger brain later on.

The researchers were also able to look at the expression of genes in individual cell types of the brain organoids. They measured the expression of a gene by looking at the levels of a messenger molecule that is made from reading DNA and is necessary to direct the formation of proteins. By comparing gene expression in cells that were developing to become the cerebral cortex which plays an important role in advanced cognitive processes such as awareness, thought, memory, language and consciousness they detected 98 genes that were differently expressed in humans.

Gene expression doesnt tell the whole story though. Its rate is ultimately controlled by a process called gene regulation. In order to identify potential regulatory mechanisms, the authors pinpointed regions of DNA that are accessible or open at the various stages in particular cells. These accessible regions of DNA have the potential to interact with proteins and can regulate gene expression.

By comparing organoids between human and chimpanzee, the researchers were able to identify regions of DNA that were differently accessible in humans potentially playing a regulatory role. Regulatory regions of DNA are more likely to be found in close proximity to the genes they are regulating the expression of. More than 60% of the genes that were expressed differently in humans were also in close proximity to differently accessible regions. This suggests that human-specific development and gene expression is a result of evolutionary changes in regions of DNA that are capable of regulating gene expression.

A significant proportion of the regions of DNA that we already know have changed the most since our divergence from chimps were found to overlap with those being different in terms of accessibility suggesting the team has indeed highlighted key regulatory processes responsible for making us humans.

This study takes the first steps in pinpointing interesting candidate genetic regions responsible for human brain complexity. The authors do not dive deeper into the mechanisms of what the altered expression of a specific gene actually means in terms of how the brain grows and functions. It does, however, provide an excellent resource and starting point to direct future research in this direction.

This research is not only important in understanding what makes us human, but also in working out how certain human disorders may arise. Several studies have found that mutations in regions of DNA with human-specific changes are associated with neurodevelopmental disorders.

Excerpt from:
Lab-grown mini brains shed light on how humans split from great apes - The Conversation UK

In just a few years we've gone from having a limited number of Korean beauty brands available in the U.S. to pioneering curators here and getting K-beauty launches at the very same time as South Korea. And as more and more K-beauty products become widely available, it's apparent that there's no single type of K-beauty brand. We're regularly seeing everything, including cute-as-can-be, cartoonishly packaged products, elegantly presented items with incredibly effective ingredients, and, of course, sheet masks in every variety imaginable. This month, we're seeing super-affordable serums, stay-put liquid shadow, and soothing sunscreen.

Here are the latest and greatest K-beauty products from brands such as The Crme Shop, Tonymoly, and more, hitting real and virtual shelves in October.

All products featured on Allure are independently selected by our editors. However, when you buy something through our retail links, we may earn an affiliate commission.

Here is the original post:
The Best New K-Beauty Skin Care and Makeup of October 2019 - Allure Magazine

WILMINGTON, Del.--(BUSINESS WIRE)--Incyte Corporation (Nasdaq:INCY) today announced positive results from the Novartis-sponsored pivotal Phase 3 REACH2 study evaluating ruxolitinib (Jakafi) in patients with steroid-refractory acute graft-versus-host disease (GVHD). The study met its primary endpoint of improving overall response rate (ORR) at Day 28 with ruxolitinib treatment compared to best available therapy. No new safety signals were observed, and the ruxolitinib safety profile in REACH2 was consistent with that seen in previously reported studies in steroid-refractory acute GVHD.

Further analysis of the safety and efficacy data is ongoing. Novartis expects to initiate discussions with ex-U.S. regulatory authorities in 2020, and to submit REACH2 results for presentation at an upcoming scientific meeting.

GVHD is a challenging and serious disease, and physicians around the world need access to therapies that can improve outcomes for patients, said Peter Langmuir, M.D., Group Vice President, Targeted Therapies, Incyte. This positive result of the REACH2 study is excellent news for patients as it further reinforces the potential of ruxolitinib as a treatment option that can provide meaningful results for patients with steroid-refractory acute GVHD.

GVHD is a condition that can occur after an allogeneic transplant (the transfer of stem cells from a donor) where the donated cells initiate an immune response and attack the transplant recipients organs, leading to significant morbidity and mortality. There are two major forms of GVHD, acute and chronic, that can affect multiple organ systems including the skin, gastrointestinal (digestive) tract and liver.

Earlier this year, Jakafi was approved by the U.S. Food and Drug Administration (FDA) for the treatment of steroid-refractory acute GVHD in adult and pediatric patients 12 years and older based on results of the REACH1 trial. Jakafi is marketed by Incyte in the U.S.; ruxolitinib (Jakavi) is licensed to Novartis ex-U.S.

In addition, the pivotal REACH3 trial evaluating ruxolitinib in patients with steroid-refractory chronic GVHD is ongoing. A recent interim efficacy and safety analysis conducted by an Independent Data Monitoring Committee has recommended that REACH3, which is co-sponsored by Incyte and Novartis, should continue without modification. The results of the REACH3 trial are expected to be available in 2020.

About REACH2

REACH2 (NCT02913261) is a randomized, open-label, multicenter Phase 3 study sponsored by Novartis, evaluating safety and efficacy of ruxolitinib compared with best available therapy in patients with steroid-refractory acute GVHD.

The primary endpoint was overall response rate (ORR) at Day 28, defined as the proportion of patients demonstrating a best overall response (complete response or partial response). Secondary endpoints include durable ORR at Day 56, ORR at Day 14, duration of response, overall survival and event-free survival, among others. For more information about the study, please visit https://clinicaltrials.gov/ct2/show/NCT02913261.

About REACH

The REACH clinical trial program is evaluating Jakafi in patients with steroid-refractory GVHD and includes the collaborative Novartis-sponsored randomized pivotal Phase 3 trials: REACH2 and REACH3. The ongoing REACH3 trial is evaluating patients with steroid-refractory chronic GVHD with results expected next year. For more information about the REACH3 study, please visit https://clinicaltrials.gov/ct2/show/NCT03112603.

The REACH program was initiated with the Incyte-sponsored REACH1 trial, a prospective, open-label, single-cohort, multicenter, pivotal Phase 2 trial (NCT02953678) evaluating Jakafi in combination with corticosteroids in patients with steroid-refractory grade II-IV acute GVHD. For more information about the study, including trial results, please visit https://clinicaltrials.gov/show/NCT02953678.

About Jakafi (ruxolitinib)

Jakafi is a first-in-class JAK1/JAK2 inhibitor approved by the U.S. FDA for treatment of steroid-refractory acute GVHD in adult and pediatric patients 12 years and older.

Jakafi is also indicated for treatment of polycythemia vera (PV) in adults who have had an inadequate response to or are intolerant of hydroxyurea as well as adults with intermediate or high-risk myelofibrosis (MF), including primary MF, post-polycythemia vera MF and post-essential thrombocythemia MF.

Jakafi is marketed by Incyte in the United States and by Novartis as Jakavi (ruxolitinib) outside the United States. Jakafi is a registered trademark of Incyte Corporation. Jakavi is a registered trademark of Novartis AG in countries outside the United States.

Important Safety Information

Jakafi can cause serious side effects, including:

Low blood counts: Jakafi (ruxolitinib) may cause your platelet, red blood cell, or white blood cell counts to be lowered. If you develop bleeding, stop taking Jakafi and call your healthcare provider. Your healthcare provider will perform blood tests to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Tell your healthcare provider right away if you develop or have worsening symptoms such as unusual bleeding, bruising, tiredness, shortness of breath, or a fever.

Infection: You may be at risk for developing a serious infection during treatment with Jakafi. Tell your healthcare provider if you develop any of the following symptoms of infection: chills, nausea, vomiting, aches, weakness, fever, painful skin rash or blisters.

Skin cancers: Some people who take Jakafi have developed certain types of non-melanoma skin cancers. Tell your healthcare provider if you develop any new or changing skin lesions.

Increases in cholesterol: You may have changes in your blood cholesterol levels. Your healthcare provider will do blood tests to check your cholesterol levels during your treatment with Jakafi.

The most common side effects of Jakafi include: for certain types of MF and PV - low platelet count, low red blood cell count, bruising, dizziness, and headache; and for acute GVHD low red blood cell counts, low platelet counts, low white blood cell counts, infections and fluid retention.

These are not all the possible side effects of Jakafi. Ask your pharmacist or healthcare provider for more information. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Before taking Jakafi, tell your healthcare provider about: all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had tuberculosis (TB), or have been in close contact with someone who has TB, have or had hepatitis B, have or had liver or kidney problems, are on dialysis, have a high level of fat in your blood (high blood cholesterol or triglycerides), had skin cancer or have any other medical condition. Take Jakafi exactly as your healthcare provider tells you. Do not change or stop taking Jakafi without first talking to your healthcare provider.

Women should not take Jakafi while pregnant or planning to become pregnant. Do not breast-feed during treatment with Jakafi and for 2 weeks after the final dose.

Full Prescribing Information, which includes a more complete discussion of the risks associated with Jakafi, is available at http://www.jakafi.com.

About Incyte

Incyte Corporation is a Wilmington, Delaware-based biopharmaceutical company focused on the discovery, development and commercialization of proprietary therapeutics. For additional information on Incyte, please visit the Companys website at http://www.incyte.com.

Follow @Incyte on Twitter at https://twitter.com/Incyte.

Forward Looking Statements

Except for the historical information set forth herein, the matters set forth in this press release, including statements regarding whether and when the REACH2 data will be presented, when results from the REACH3 study will be available, and the effect of the REACH2 results on patients with GVHD, contain predictions, estimates and other forward-looking statements.

These forward-looking statements are based on the Companys current expectations and subject to risks and uncertainties that may cause actual results to differ materially, including unanticipated developments in and risks related to: unanticipated delays; further research and development and the results of clinical trials possibly being unsuccessful or insufficient to meet applicable regulatory standards or warrant continued development; the ability to enroll sufficient numbers of subjects in clinical trials; determinations made by the FDA; the Companys dependence on its relationships with its collaboration partners; the efficacy or safety of the Companys products and the products of the Companys collaboration partners; the acceptance of the Companys products and the products of the Companys collaboration partners in the marketplace; market competition; sales, marketing, manufacturing and distribution requirements; greater than expected expenses; expenses relating to litigation or strategic activities; and other risks detailed from time to time in the Companys reports filed with the Securities and Exchange Commission, including its Form 10-Q for the quarter ended June 30, 2019. The Company disclaims any intent or obligation to update these forward-looking statements.

Original post:
Incyte Announces that the REACH2 Pivotal Trial of Ruxolitinib (Jakafi) Meets Primary Endpoint in Patients with Steroid-Refractory Acute...

WHEN teacher Matt Meads started suffering with stomach pains, night sweats and tiredness - he quickly dismissed it as end of school year fatigue.

He was fit and healthy, and avoided drinking and smoking.

8

But just three weeks after first falling ill, Matt died - aged just 33 - and after just three chemo sessions.

He and his wife Abi were devastated when they discovered his symptoms were actually a sign ofleukaemia.

Heartbroken Abi, 27, from Nottingham, is now sharing his story to raise awareness and to urge others to be vigilant for signs of acute lymphoblastic leukaemia, a rare and aggressive form of blood cancer.

"I've got so many people around me offering help and support but I still feel really lonely because I've lost my best mate, my husband, my soulmate," Abi said.

It comes as blood cancer charity Bloodwise warns thousands of people are dying of the disease because it's diagnosed too late.

Matt and Abi first suspected something was wrong on July 6, when he began feeling more and more fatigued.

8

8

And when he started vomiting to the point of being unable to keep ice cubes down, Abi urged him to go to the doctor.

At first he was told by his GP he had gastroenteritis or constipation but he soon returned to the hospital for a second time where they did a blood test.

Abi, who works as a teacher too, said: "Obviously I wish it was spotted sooner.

"I don't feel any anger towards to the hospital.

"I genuinely believe they did everything they could for him.

"He would say he was feeling sick."He would send a text saying he wasn't feeling well so was going to bed. I was out with some friends.

8

"He said something about feeling hot as well, but we didn't put that down to anything because it was the middle of summer and everyone was feeling hot.

"He was sleeping a lot, particularly at weekends which he would spend mostly asleep.

"But we're both teachers, it was coming up to the end of the school year and we had both got a lot of work on.

"We put it down to the job, and just tried to keep going because we had five weeks off soon.

"We thought it was the usual fatigue that we feel at the end of the year.

"There were sickness bugs going around at both of our schools so it wasn't anything out of the ordinary.

"He was referred to A&E for the second time thinking it was gallstones.

I've got so many people around me offering help and support but I still feel really lonely because I've lost my best mate, my husband, my soulmate

"They did some blood tests on him, sent him for a CT scan. The doctor came back and basically said that it was leukaemia."

Despite the devastating diagnosis, Abi said her brave husband remained positive as he came to terms with what was really happening.

She added: "Matt was a really positive person and was always somebody who believed what would be would be, it is what it is and all that stuff.

"So when the doctor told him he was quite composed.

"He didn't really give anything away about what he was feeling.

"It was obviously a massive shock for him but he didn't really respond in the way I would have done. He was listening to the doctor.

8

8

"The doctor actually stopped at one point because he was explaining what would happen next.

"He actually stopped at one point to ask him if he was okay, it was really big news and is he taking it all in?

"Matt's response was, 'yes, but there's nothing I can do about it. It is what it is'.

"He was definitely really brave."

And Abi says the diagnosis came as even more of a shock given how healthy he was.

8

She was forced to watch her husband go from happy and sporty to intensive care within days, before he passed away from a pulmonary embolism after just three chemotherapy sessions.

She said: "We knew he was poorly, but maybe not quite how poorly he was.

"I certainly wasn't expecting a phone call from the hospital.

"I don't know how I am now. It's hard. I don't think I really started to grieve until after the funeral.

"It's hard to think ahead for anything. It's a case of taking everything one day at a time.

"Some days are better than others. Some days are horrific and I don't want to get out of bed.

What is Acute Lymphoblastic Leukaemia?

Acute lymphoblastic leukaemia (ALL) is a type of blood cancer that starts from young white blood cells called lymphocytes in the bone marrow.

Adults and children can get it but it is most often diagnosed in younger people.

It'svery rare, with around 650 people diagnosed with the condition each year in the UK.

Many symptoms of ALL are vague and non specific. It may feel like the flu as symptoms are caused by too many abnormal white blood cells and not enough normal white cells, red cells and platelets.

Symptoms can include:

Recently blood cancer charity Bloodwise warned thousands of patients in England could be unnecessarily dying from blood cancer because they are diagnosed too late.

Experts analysed NHSdata and found 28 per cent of patients are told they have the disease after needing emergency treatment for their symptoms.

Figures show there are around 40,000 cases of blood cancer - a group of diseases including leukaemia, lymphoma and myeloma - each year in the UK.

Around 77 per cent of patients will survive for three years if they are diagnosed after visiting their GP, Bloodwise says.

In contrast, the same survival rate plummets to just 40 per cent for patients who are diagnosed as an emergency.

This is because symptoms develop over a few weeks and become more severe as the number of immature white blood cells increases.

"Matt was a really happy person. He was really positive.

"He was kind, caring, loving, wicked sense of humour. He would make a joke about anything and was very quick-witted.

"As a teacher he would have done anything for his students. He would have done anything for his family.

"He was just a really positive person who would have done anything for anybody.

"He loved his sport. He would go to the gym, he loved being outside and walking. He liked cycling. He was careful about what he ate.

"Everything the doctors warn you about, he didn't do. He didn't drink, he didn't smoke, he had a good diet, he exercised.

If you've got any of the symptoms which are lasting or you can't explain why you've got them, you need to go to the doctor and get checked out and be persistent in asking for a blood test

"He always put sun-cream on because he was paranoid he might catch skin cancer or something.

"He did everything he could to try and prevent anything from happening to him.

"As the doctors said there was nothing he could have done to prevent this."

Abi is now speaking out to urge others to get checked out and insist for a blood test if they have persistent symptoms of blood cancer.

She said: "If you've got any of the symptoms which are lasting or you can't explain why you've got them, you need to go to the doctor and get checked out and be persistent in asking for a blood test.

8

"You know your own body. It's as simple as having a blood test.

"If you've got it for days and it's not getting any better, if you're in any doubt, get it checked.

"We didn't know what the symptoms were.

"The only one I knew was bruising, but Matt didn't have any bruises until he was in hospital. So the one thing I knew wasn't relevant.

"I didn't realise about the night sweats, fatigue or heavy breathing.

"We never expected it would be that.

"We had thought worst case scenario it was gallstones or an impacted bowel, so when he came and said leukaemia it was just unexpected.

"When you're poorly you have all these possibilities going through your head but you never think it's going to be that.

ARE YOU AT RISK? The 8 signs of lung cancer to never ignore after Emmerdale star's death

Warning

terror vision I heard a pop and lost my eye when I dried my face with a towel

ACHES AND GAINS Poundland gel hailed as easing back pain in just ONE application

'IT WAS SO BIG' Teen 'gives birth to tumour' after periods turn out to be cervical cancer

HIGH HOPES Dying dad claims CBD oil and dog worming tablets have stopped cancer in tracks

SNORE OFF New battery-powered buzzer could be the secret to stopping your partner's snoring

WOMB WITH A VIEW Incredible photos show baby boy born still INSIDE his amniotic sac

WEIGH TO GO I shed 13 stone without counting calories & now I'm a new person

HERO AMONG MEN Dad who died after 'extreme headache' saves FIVE lives donating his organs

HARDEST MOMENT We screamed as our baby boy took his last breath at four hours old

"I had a really good chat with Matt's consultant where I questioned whether I should have done more, if I had spotted things sooner, whether if I had been more pushy in getting him to hospital.

"But the symptoms are vague and it can come on within days. It doesn't have to be something that has been happening for weeks or months."

You can donate on Abi's fundraising page in memory of Matt here.

Visit link:
Fit and healthy teacher dies 20 days after discovering he had leukaemia at 33 - The Sun

The Duchess of York, affectionately known by British royal fans as Fergie, shared the cover of The Perfect World Magazine, where she can be seen giving Sir David Attenborough an honorary award. Fergie, who turns 60 today, revealed in an Instagram post that moment is one of the best of her life.

She wrote on Instagram: "Thank you all for the birthday messages! This is one of the highlights of my life."

In the cover, Fergie can be seen smiling as she hands the award, shaped like a rhino, toSir Attenborough, the world-famousEnglish broadcaster and natural historian.

Fergie andSir Attenborough attended together last September thePerfect World Foundation gala dinner, where she will present him the award.

The same award has been previously given toMark Shand, the late brother of the Duchess of Cornwall, and primatologist Dr Jane Goodall.

In the early afternoon, the Duchess of York published on Instagram another picture, showing her wearing a colourful sari.

She added in the caption: "Colourful moments"

Fergie's Instagram messages come after her former husband Prince Andrew celebrated her birthday on social media.

Earlier this morning, the Duke of Yorkpublished two identical messages dedicated to Fergie on both Instagram and Twitter.

READ MORE:How Fergie was 'forced to cancel birthday party due to crisis'

The messages read: "Wishing Sarah Ferguson a very Happy 60th Birthday!"

On Instagram, the message was accompanied by three pictures, one depicting Sarah surrounded by members of the York family, including Princess Eugenie's husband Jack Brooksbank and Princess Beatrice's fiancee Edoardo Mapelli Mozzi.

The second picture shows Fergie surrounded by children supported by the charity she is a patron of, Street Child UK.

And the third snap depicts Eugenie, Beatrice and Fergie together while carrying out an engagement.

DON'T MISS

Fergie has previously spoke with enthusiasm about her approaching 60th birthday.

Speaking at a charity event held onbehalf of Street Child and hosted by Hello, the Duchess said:"I think it's really important that my life is beginning at 60, I'm so excited by it."

Outspoken Fergie also revealed she has undertaken laser treatment to her skin to look her best for her milestone birthday.

Similarly, the Duchess had laser also before the wedding of her youngest daughter Princess Eugenie, which helped to make her skin glow.

But these haven't been the only beauty treatments Fergie has undertaken in the past years.

In March this year, Fergie travelled to the Bahamas toundergo stem cell therapy - an alternative to surgery which is yet to be proven fully safe and effective on humans and is therefore not widely available in the UK.

This therapy helped her solving a painful problem related to her feet, which eventually forced her to stop wearing high heels.

I went to the Bahamas in March to have the treatment.

I think my toes were ruined by all the riding I did when I was young.

Visit link:
Sarah Ferguson reveals highlight of my life as she celebrates 60th birthday - Express

New York City, NY: Oct 16, 2019 Published via (Wired Release) MarketResearch. Biz has a big history of serving detail research reports that help to create business opportunities through competitive study. One of the report we provide is Anti-Aging Drugs market analyzing market latest trends, identifying your rivals, validating opportunities, examining threats to your company, and changing your go-to-market and positioning strategy respectively.

The report on the Global Anti-Aging Drugs Market 2019 has been portrayed by experienced and knowledgeable market analysts and researchers. It is a phenomenal compilation of vital studies that explore the competitive landscape, segmentation, geographical exploration, and revenue, production, and consumption growth of the Global Anti-Aging Drugs market. Players can use the accurate market facts and figures and statistical analysis provided in the report to understand the current and upcoming growth of the Anti-Aging Drugs market. The Global Anti-Aging Drugs market size was XX Mn US$ and it is expected to reach XX Mn US$ by the end of 2028, with a CAGR of XX% during 2019-2028. The report includes CAGR, market shares, sales, Anti-Aging Drugs gross margin, value, volume, and other crucial market figures that give an exact view of the growth of the Anti-Aging Drugs market 2019.

Advanced primary and secondary research techniques and tools have been used by our Anti-Aging Drugs market analysts to compile this report. We use research sources and tools that are highly reliable and trustworthy. The Anti-Aging Drugs market report provides effective guidelines and recommendations for leading players to secure a position of strength in the worldwide market. Anti-Aging Drugs Market Emerging players can also use this research study to plan business strategies and get informed about upcoming challenges in the market. We provide an extensive competitive analysis that includes detailed company profiling of key players, a study on the Anti-Aging Drugs nature and characteristics of the competitors landscape, and other important studies.

For Detail Insight Go With This Free Sample Report Enabled With Respective Tables and Figures:https://marketresearch.biz/report/anti-aging-drugs-market/request-sample

Major Players of the Global Anti-Aging Drugs Market 2019

La Roche-Posay, DermaFix, Nu Skin, Allergan, Procter & Gamble, BIOTIME Inc, Elysium Health Inc, Solta Medical, LORAL and Johnson and Johnson

Market Segmentation:

Segmentation by Product Type: serums and Supplements, antioxidants and Enzymes, stem cells and Drugs. Segmentation by Application: skin and Hair, skeletal and Muscles, age Related Disorders

Global Anti-Aging Drugs Market: Regions and Countries

The research study comprises key results and discoveries of our monitoring and analysis of the Anti-Aging Drugs market 2019. We have provided crucial information points, which include expansions, divestments, new product launches, Anti-Aging Drugs partnerships, mergers, acquisitions, and other strategic initiatives taken by Anti-Aging Drugs market players. The report also serves price trends for region-wise markets and analysis of crucial market events on a regional as well as worldwide scale. Our analysis will guide you to take vital decisions in the Anti-Aging Drugs market relating to procurement, inventory, pricing, and production. We assist you to give a tough competition to your rivals by providing latest, actionable, real-time, and quick market information.

The report will help you to get how and whether or not the worldwide Anti-Aging Drugs market 2019 has become customer-centric. It offers details insights into customer needs and preferences for players to expand their brand value, connect better with their clients, and improve their sales in the Anti-Aging Drugs market globally. As part of our customer insights, we focus on product positioning, customers perception of Anti-Aging Drugs market competition, customer segmentation, customer needs, consumer buying behavior, and target customers.

Have Any Query Or Specific Requirement? Feel Free To Ask Our Industry Experts: https://marketresearch.biz/report/anti-aging-drugs-market/#inquiry

Our competitor profiling comprises validation of distribution channels and products and services offered by and Anti-Aging Drugs financial performance of companies operating in the market 2019. We also give Porters Five Forces, PESTLE, and SWOT analysis to identify the competitive threat and study other aspects of the Anti-Aging Drugs market. The report provides strategic recommendations, competitor benchmarking for performance measurement, and study of partnership, merger, and acquisition targets and Anti-Aging Drugs industry best practices. It also offered an analysis of profitability and cost across the Anti-Aging Drugs industry value chain.

Core Objective of Anti-Aging Drugs Market:

Every firm in the Anti-Aging Drugs market has objectives but this market research report focus on the crucial objectives, so you can analysis about competition, future market, new products, and informative data that can raise your sales volume exponentially.

Size of the Anti-Aging Drugs market and growth rate factors.

Important changes in the future Anti-Aging Drugs Market.

Top worldwide competitors of the Market.

Scope and product outlook of Anti-Aging Drugs Market 2019-2028.

Developing regions with potential growth in the future.

Tough challenges and risk faced in market.

Global Anti-Aging Drugs top manufacturers profile and sales statistics.

Anti-Aging Drugs Market Dynamics 2019-2028.

Browse Full Summary of Anti-Aging Drugs Market Enabled with Respective Tables and Figures at: https://marketresearch.biz/report/anti-aging-drugs-market/

Customize report of Global Anti-Aging Drugs Market as per client requirement also available. Please connect with our sales team (inquiry@marketresearch.biz), who will ensure that you get a report that suits your needs.

Contact Us:

Mr. Benni Johnson

Prudour Pvt. Ltd.

420 Lexington Avenue,

Suite 300 New York City, NY 10170,

United States

Tel: + 1-347-826-1876

Website: https://marketresearch.biz/

Continue reading here:
Anti-Aging Drugs Market Innovations, And Top Companies - Forecast To 2028| Allergan, Johnson and Johnson, Nu Skin - Healthcare News

LESS than a week away from her 60th birthday, Sarah Ferguson has revealed that she has had Botox, two types of facelift and organic fillers to wind back the clock.

Many royal fans marvelled when the Duchess of York stepped out looking surprisingly youthful for her daughter Princess Eugenies high profile royal wedding last year.

7

Addressing rumours of cosmetic surgery, Fergie has confessed that her looks arent entirely natural and she has had professional tweaks.

Speaking to the Mail, she said: The happiness was shining out of me because my daughter was getting married. I was so glad. I love Jack. When Im passionate about anything, my eyes shine.

Above all, it was being joyful for Eugenie that made me look good. But Id had some laser treatment on my face which helped, too.

Although she previously had Botox to tackle facial lines, Sarah admitted she now prefers having laser cosmetic procedures, which are pain-free, non-invasive and take just 90 minutes.

7

Mum-of-two Sarah goes to Harley Streets Dr Gabriela Mercik, who is the creator of the worlds first 6-Dimension Ultimate Laser Treatment facelift, which Fergie has now tried.

Sarah first met Dr Gabriela in 1992 when the royal was visiting young cancer victims in Upper Silesia, Poland.

At the time, Dr Gabriela was a medical student helping to treat the patients, and she ended up staying in touch with loyal Sarah.

Fergie first became one of her customers after Gabriele opened her own aesthetic clinic in the UK, and the royal felt her fair skin was too exposed to sunshine as a child.

Sarah said: I live on jingly-jangly nerves. Im very focused, earnestly intense, but I live at high speed. I dont sit down for long. Im always saying to Dr Gabriela, Come on, come on! Hurry up! Im the worst patient.

7

7

She opts for the rejuvenating ultimate facelift, which can be done in a lunch hour and involves boosting the skins production of collagen.

Fergie admitted she had Botox a long time ago when alternative treatments werent on the market, but she now prefers having the facelifts.

The royal said shes not a fan of the frozen look as she is so animated, and also hates needles.

Despite her fears of the surgical tool, she opted for a mesotherapy beauty treatment at the clinic in 2013, which is when vitamins, minerals and amino acids are injected under the faces mesodermal layer to plump skin.

Now she has moved on to organic fillers, which are non-invasive injectable used to tackle lines and wrinkles.

7

Five years ago, Dr Gabriela suggested Sarah had a thread lift also known as a puppet lift which is when threads are inserted in to the skin to make a mesh which pulls the face upwards.

Although results last for two years, the threads dissolve over six to eight months.

Sarah said: Before I had it done I thought, Oh this is going to be painful, but it wasnt bad. My skin responded well. I think if you look at photos of me after I had it done, I look much better.

She now hopes the 3,750 6-Dimension Ultimate Laser Treatment facelift will help her look her best for her 60th birthday milestone next Tuesday.

The doctor confirmed that Sarah does pay for treatments at her discretion as the pair have become close friends.

7

Sarah admitted that the drive to have facial cosmetic surgery comes from skin damage that started from a young age, when her mum incorrectly thought Nivea moisturiser could be used as sunscreen.

The royal was also motivated to take care of her skin after her dad, Major Ronald Ferguson, passed away from skin cancer in 2003, and her best friend Carolyn Cotterell also died of a malignant melanoma when she was 43.

She now admits any tan she has is from a bottle and she hopes to rebuild her collagen by her birthday.

My skin responded well. I think if you look at photos of me after I had it done, I look much better.

In March she revealed she flew to the Bahamas to have a regenerative stem cell therapy on her feet, after feeling her toes were ruined by frequent horse riding when she was young.

Doctors shaved a spot near her big toe and implanted 20 million stem cells from her midriff into the cavity to make new cartilage.

Due to the surgery not yet being proven to be safe, the UK does not widely offer the treatment.

She may be turning 60, but Fergie insisted in July this year, at the launch of a British Heart Foundation campaign, that she feels sexy, sassy and super saucy.

7

The proud mum has recently shared how excited she is for her eldest daughter, Princess Beatrice, to get married next year.

Taking to Instagram last month, Fergie shared six photos of the 31-year-old princess with her millionaire husband-to-be Edoardo Mapelli Mozzi.

She later shared a tweet, writing: "I know what a mother feels so I have tears of joy. I am so proud of this sensational news.

Andrew and I are just the luckiest people ever to have two great sons in law."

HELPING HAND The Queen is looking for a butler to work on less than the London living wage

TRASH TALK Harry says he was bullied at school for picking up litter after copying Charles

out of africa Meg & Harry's royal tour doc to reveal 'world pain behind the brave faces

MEG-A AWKS Meghan & Harry apologise for awkward typo & call it a hiccup in new Insta post

MEGA CUTE Harry told Meg she 'looked amazing in pre-pregnancy dress at WellChild Awards

'SECURITY FEARS' Kate & William's Pakistan tour - where are they going & when did it start?

Sarah recently confirmed that the "only place" Beatrice can get married is Britain.

Meanwhile its been claimed Beatrice is ready to start a family with multi-millionaire property tycoon Edoardo.

And Fergie recently honoured the family of a teen who died from severe allergy reaction after eating Pret a Manger sandwich.

See the original post:
Sarah Ferguson admits shes had Botox, TWO types of facelift and vitamin injections in a bid to stay youthful - The Sun

The members of the British royal family are always in the public eye. They cant blow their noses without people hearing about it. But with so much attention, comes even more scrutiny.

The royals are under pressure to be perfect at all times. Every move they make is photographed by the paparazzi and the public isunforgiving. Even after they gave birth, people expected both Meghan Markle and Kate Middleton to be back to their normal thin frames in a matter of days.

When celebrities are feeling the pressure to keep up appearances, many of them seek out plastic surgery procedures. Does the royal family do the same?

For many people, the Duchess of Cambridge is the epitome of style and grace. Youd be hardpressed to find a photo of Middleton looking less than perfect. Because of this, people have often wondered if the future Queen Consort has had any work done.

Earlier this year, Dr. Munir Somji of Dr. Medi Spa Clinic in London claimed that Middleton was one of his clients.

He shared before and after pictures of the Duchess on his Instagram.

Our Kate loves a bit of baby Botox, he wrote under the photos, which have since been deleted.

View this post on Instagram

The Duchess of Cambridge, Patron of the @Natural_History_Museum, visited the Angela Marmont Centre for UK Biodiversity to hear how it is championing and helping to protect UK wildlife. The Angela Marmont Centre (AMC) is a unique scientific hub located in the Natural History Museum, and is dedicated to the study of the UKs natural world. The AMC helps public visitors identify their finds, provides vital training in wildlife identification, and leads research and citizen science projects that are helping to transform our understanding of over 80,000 species of wildlife known to exist in the UK today. With populations of many UK species declining, and a significant proportion threatened with local extinction, the AMC brings together a host of individuals and organisations all dedicated to building understanding of the UKs wildlife, so that it can be better protected for future generations. AMC staff work with colleagues from across the Natural History Museum to carry out a range of scientific research to study how and why the UKs wildlife is changing. This ranges from applying ground-breaking scientific techniques, including analysis of environmental DNA through to detecting and identify the miniscule insects and microorganisms that play an important role in healthy environments. At the AMC today The Duchess viewed some of the Museums specimens and saw DNA sequencing live in action.

A post shared by Kensington Palace (@kensingtonroyal) on Oct 9, 2019 at 5:20am PDT

Note the reduction of fine lines on the forehead, he continued. But also note the depression of the medial (middle part) brow but elevation of the lateral tail of the brow.

So many people started believing the rumor that Kensington Palace gave a statement to the New York Post.

A spokesperson for the palace said that the post by Dr. Somji was categorically not true and in addition, The Royal Family never endorse commercial activity.

One royal who has been open about the procedures shes had done is the Duchess of York, Sarah Ferguson.

Ive had a lot of help to look like this at 60! she said in an interview withDaily Mail.

Ive started the laser treatment, but its not finished yet, she continued. The collagen needs to rebuild. I hope it will all be done by my birthday.

She also had this treatment before her daughter, Princess Eugenies, wedding last year. The procedure was done by Dr. Gabriela Mercik in a facility in London.

I dont like the frozen look, Ferguson said of why she chooses more natural procedures. Im so animated and I like to be myself. I dont like the thought of needles and am very glad if I look well and happy Im really happy to be open about what Ive had done.

Originally, the Duchess tried botox but has since switched to less invasive procedures, like her most recent treatment which refines the skins texture.

Shes also had mesotherapy, which is a non-surgical cosmetic treatment.

I need to repair the damage that was done on the beach when I was a child, she continued. Its why I had the mesotherapy, the vitamin cocktail to hydrate and boost the skin.

Not only does Ferguson get work done on her face, but she makes sure her feet are perfect as well!

I think my toes were ruined by all the riding I did when I was young, she said. They shaved the bone here. And implanted stem cells, 20 million of them taken from my midriff, into my feet to make new cartilage. It takes about six months to heal but now I can walk in heels!

Read more:
Which Plastic Surgery Procedures Have Members of the Royal Family Had Done? - Showbiz Cheat Sheet

Many of us rely on makeup as the secret to eternal youth. From covering up dark circles with concealer to adding a flush of colour with a rosy blush it's the perfect little pick-me-up.

But, of course, it's never that simple.

And if you're using the wrong products or the wrong techniques, you may not end up quite as fresh faced as you had hoped.

From using too much powder foundation to forgetting to use SPF, many of our go-to habits could actually be making us look older.

We speak to skin expert Paul Banwell to find out exactly what we should and shouldn't be doing.

To keep your skin hydrated, Paul says you can use simple methods to keep looking youthful.

He says: You can use a high intensity moisturiser, or use indigestible products like a liquid collagen drink - I recommend Skinade, the leading collagen drink which is carefully formulated, a mixture of vitamins and minerals which results in optimal skin health.

Wearing oil based products can clog pores and cause breakouts.

Paul says: The effects of clogged pores can be aided with medical facials like the photogenic facial from TBC Skin atelier, or microdermabrasion, followed by Dermalux LED treatments.

Alternatively, I'd recommend a hydroxyacid boost for pH equilibrium and chemical exfoliation - Rationale's Catalyst Range is best.

However, you can also make a difference by making small changes at home.

Paul says: Similarly, overusing fragranced and alcohol based products may dry out the skin, and in turn cause premature lines and wrinkles.

Try to use oil free products, and aim to use hydrating foundations and creams.

Pollution can be responsible for skin dryness, dullness, clogged pores and skin ageing.

Paul says: Some tips for shielding your skin from pollution are wearing sunscreen, using a good moisturiser to create a barrier between your skin and pollutants and double cleansing your skin - use a product like the Rationale Catalyst cleanser.

Sun exposure, both UV and infrared, can result in sunburn which also causes ageing issues for the skin as the years pass.

They're often credited with giving us a matte, flawless finish but powder foundations can be one of the worst culprits when it comes to ageing. Paul says: Avoid powders, as they tend to set into the fine lines of wrinkles which can make your skin look flaky.

For immune protection, and a product which can be used during a Sunday night ritual to make your skin look fresh and luminous for the week ahead which means you won't need to wear foundation, use the immunologist mask - to be performed weekly (the pot lasts 6 months).

It hydrates and reduces inflammation in problem/ sensitive skin.

While concealers are great for hiding flaws and imperfections, they can also draw attention to any unwanted lines and wrinkles.

Paul says: Concealers might be covering the dark circles, but they also accentuating fine lines, so make sure to only apply concealer to the inner half of your under eye.

Prepping the skin before wearing makeup is also key to a youthful glow. Paul says: Skin around the eyes is thinner that the rest of your face and shows age faster!

Eye creams and products that contain Retin A, a form of vitamin A, are most effective and promote the stimulation of collagen and elastin to tighten the skin.

Suncream shouldn't just be reserved for your annual holiday or trips to the beach. Rather, it should be part of your daily skincare regime.

Paul explains: UV exposure causes 90% of skin damage. Even people who already have signs of premature skin ageing can benefit from making lifestyle changes.

We should all be protecting our skin by using SPF 30 or higher which gives your skin a chance to repair some of the damage.

Fine lines and wrinkles absolutely have a part to play here too, and the best way to eradicate these is through protecting the skin against phototoxic damage and minimising loss of skin integrity.

Collagen peptides in a drink like Skinade will increase collagen turnover and are proven to minimise fine lines.

At the Banwell clinic, we offer Ultimate Sunscreen protection with Rationale B3-T, which will ensure skin is not affected as strongly when in sunlight.

After a long day, it can be tempting to just roll into bed without a second thought for your skin. But you may end up paying the price as a result.

Paul says: Sleeping in your makeup can result in the breakdown of healthy collagen which leads to premature skin ageing. Make sure to take your makeup off thoroughly, and Id recommend a Plasma Shower facial to boost cleansing of the skin, using stem cell technology.

Plasma showers alone help improve texture and quality of skin but can be boosted by various mesotherapy treatments including stem cells, hyaluronic acid and vitamins.

Essentially it encourages hydration, which is essential for optimum physiological functioning of the skin and to optimise all biological processes and immune protection.

Read the rest here:
Make-up mistakes that make you look older - and item that should go in the bin - Mirror Online

PITTSBURGH (KDKA) In a dish sits a human liver.

Not removed from a person, but created from scratch.

Its not like wahoo and the next morning you think, ah, Im gonna make a human liver,' says Dr. Alejandro Soto-Gutirrez of the Pittsburgh Liver Research Center.

It took five years of trial and error but using stem cells, genetic and tissue engineering, organ cultures and a team of experts in these areas, the researchers have come up with this.

Alexandra Collin de Lhortet, Ph.D. of the University of Pittsburgh School of Medicine explains the process.

A rat liver gets stripped of its cells so that only the connective tissue remains.

From a small piece of human skin, the scientists pluck out stem cells and coax them into becoming human liver cells and the cells are collected.

Then theyre injected into the chamber, called a bioreactor, where they take up residence in the empty rat liver.

The entire process from gathering the cells to make a liver, to get to this point, where you have an actual mini human liver in a bioreactor, takes several months.

It will stay alive, or viable, for only a few days.

But in that short time, the researchers can try different medicines to treat the diseased liver.

You could test any sort of therapeutic by simply injecting this chemical through the system, says Dr. Collin.

In the past, animal livers played a role in this kind of research but human livers didnt always respond in the same way.

With this system, the cells have had genetic modification to recreate diseases, for example, fatty liver, a growing problem in the United States.

This technology has the potential for personalized medicine. From your skin cells, they could grow your own mini liver to figure out which medicines would work for you.

I believe its a very good biological tool to screen treatments that are not otherwise being tested in humans themselves because its dangerous, says Dr. Soto.

As its designed, it would be a long stretch to create livers for transplantation.

If you mean how far we are to make actual livers for people, I think we are very far away. Were probably many years away. But this is a good step, Dr. Soto says.

More:
After 5 Years Of Trials, Doctors Create Human Liver From Scratch - CBS Pittsburgh

Jenni Murray is spot on staying slim can take its toll on your features, says Christa DSouza

I do love Jenni Murray. For telling it like it is. For those of you not aware of the comments she made at the Henley literary festival, let me recap for you. She recalled the advice given to her by Barbara Cartland Jenni, you know, when you get older you sacrifice your face or your figure. Dont sacrifice your face, just sit down a lot. Murray went on to explain how, despite having gone through a gastrectomy to lose weight, she had, at the age of 69, decided to follow Babss advice because she didnt want to end up looking like Nigel Lawson. And thats no insult to Nigel Lawson, she went on to say in her mellifluous, unbitchy way, but you know, when he

Want to read more?

Subscribe now and get unlimited digital access on web and our smartphone and tablet apps, free for your first month.

Read more:
Do you have 'diet face'? It's everywhere | Times2 - The Times

PURE Cell Facial

Stem cells are controversial in medicine, but not in beautyat least not when it comes to the PURE Cell Facial available at the PURE Spa inside the Pelican Grand on Fort Lauderdale beach. The live roseroot stem cells used during this 80-minute service travel deep into the pores to regenerate skin and stimulate collagen. The spa is one of only two locations to offer the treatment, which uses products from Maria kerberg. Products are deepened into the skin using a mask that feels as thick as the molds orthodontists stick in your mouth to create retainers. The treatment makes the skin look tighter, and results can last four to six weeks. (2000 N. Ocean Blvd.,Fort Lauderdale; 954.556.7600) - Alyssa Morlacci

Forget everything you thought you knew about a relaxing massage and prepare yourself for ultimate bliss with the help of a quartz sand bed. Lucky for South Floridians, The Spa at Auberge Beach in Fort Lauderdale offers the award-winning, state-of-the-art Gharieni Quartz Treatment table (only one of two in South Florida) known to ionize the air, which supports the immune system and helps purify the body. During a massage, tight muscles are soothed with quartz sand poultices, targeting specific areas of concern. Guests interested in trying the bed can do so when booking the Resort and Balance Massage, the Quartz Sand Sound and CBD Wrap, or the Quartz Massage with Amethyst Oil. (2200 N. Ocean Blvd., Fort Lauderdale; 754.900.4067) - Melissa Puppo

This month, relax and rejuvenate with a wealth of treatments and packages starting at $99. Portions of proceeds benefit five local charities in support of Breast Cancer Awareness Month.

Four Seasons ResortPalm Beach

Take part in the 100-minute Pink Oceana Experience Package, which features a warm scalp treatment and massage and warmed application of a detoxifying ancient ocean clay wrap mixed with exfoliating Himalayan salt, all followed by a full-body Himalayan Salt Stone Massage. The treatment also includes your choice of sparkling ros or antioxidant-infused hibiscus tea and a Himalayan Salt Detox Bath Soak to take home. Enjoy pool, beach and fitness room access, in addition to a voucher for breakfast or lunch, and a 10-percent discount on all spa retail.(2800 S. Ocean Blvd., Palm Beach; 561.582.2800; $390)

Palm Beach Marriott Singer Island Beach Resort & Spa

For a facial thats ideal for all skin types, book the Si-Rose Facial Treatment. During the 50-minute treatment, rose extracts and rosehip oil help skin to restore vital hydration and balance. Its then followed by a warmed rose quartz massage to help increase circulation. (3800 N. Ocean Drive, Riviera Beach; 561.340.1755; $99)

The Sanctuary Salon & Spa

Get the best of both worlds with the Fire & Ice Sensation Package. This treatment includes a harmonized, rhythmic massage utilizing hot and cold remedies designed to reduce stress, relax and detoxify the body. Organic oil blends are then warmed for a custom therapeutic conditioning treatment before finishing up with a designer blowout. (101 N. Clematis St., Ste.115, West Palm Beach; 561.721.9648; $99)

Read this article:
Must-Try Spa Treatments During The Palm Beaches' Spa And Wellness Month - Jupiter Magazine

IRVINE, Calif., Oct. 2, 2019 /PRNewswire/ --AIVITA Biomedical, Inc., a biotech company specializing in innovative stem cell applications, today announced the publication of an article titled "Preliminary observations on soluble programmed death-1 protein as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines" in the oncology journal Oncotarget. Robert O. Dillman, M.D., Chief Medical Officer at AIVITA, and other key members of the AIVITA team authored the article.

The publication suggests that because of its role as an immune checkpoint, levels of soluble programmed cell death protein-1 (sPD-1) could be useful as a prognostic biomarker or predictive biomarker in cancer patients treated with vaccines. The authors theorized that very low blood levels of sPD-1 may indicate lack of an existing anti-cancer immune response, while very high levels may indicate an active immune response that is suppressed. In between these extremes, a decrease in PD-1 following cancer vaccine injections may indicate an enhanced immune response that has not been suppressed.

Blood samples were obtained at baseline and four weeks later during a randomized trial in which patients with metastatic melanoma were treated with either AIVITA's immunotherapy, or an active control article. Median survival was more than twice as long in patients treated with AIVITA's immunotherapy. The combination of a very low baseline sPD-1, or absence of a very high PD-1, at baseline followed by a decline in sPD-1 at week-4 of the study was predictive of surviving 3 or more years in patients treated with AIVITA's immunotherapy, but not with the control article. Among patients treated with AIVITA's immunotherapy, these sPD-1 criteria appropriately classified 80% of 3-year survivors, and 86% of patients who did not survive three years.

"These observations suggest that sPD-1 may be a useful biomarker for melanoma patients being treated with our platform immunotherapy, and/or to predict efficacy after only three injections," said Dr. Robert O. Dillman, Chief Medical Officer at AIVITA. "We look forward to confirming these results in larger studies and investigating whether it can predict response in other cancers."

AIVITA is currently conducting three clinical studies investigating its platform immunotherapy in patients with ovarian cancer, glioblastoma and melanoma. AIVITA uses 100% of proceeds from the sale of its ROOT of SKIN skincare line to support the treatment of women with ovarian cancer.

CLINICAL TRIAL DETAIL

OVARIAN CANCER

AIVITA's ovarian Phase 2 double-blind study is active and enrolling approximately 99 patients who are being randomized in a 2:1 ratio to receive either the autologous cancer stem cell-targeting immunotherapy or autologous monocytes as a comparator.

Patients eligible for randomization and treatment will be those (1) who have undergone debulking surgery, (2) for whom a cell line has been established, (3) who have undergone leukapheresis from which sufficient monocytes were obtained, (4) have an ECOG performance grade of 0 or 1 (Karnofsky score of 70-100%), and (5) who have completed primary therapy. The trial is not open to patients with recurrent ovarian cancer.

For additional information about AIVITA's AVOVA-1 trial patients can visit: http://www.clinicaltrials.gov/ct2/show/NCT02033616

GLIOBLASTOMA

AIVITA's glioblastoma Phase 2 single-arm study is active and is enrolling approximately 55 patients to receive the cancer stem cell-targeting immunotherapy.

Patients eligible for treatment will be those (1) who have recovered from surgery such that they are about to begin concurrent chemotherapy and radiation therapy (CT/RT), (2) for whom an autologous tumor cell line has been established, (3) have a Karnofsky Performance Status of > 70 and (4) have undergone successful leukapheresis from which peripheral blood mononuclear cells (PBMC) were obtained that can be used to generate dendritic cells (DC). The trial is not open to patients with recurrent glioblastoma.

For additional information about AIVITA's AV-GBM-1 trial please visit: http://www.clinicaltrials.gov/ct2/show/NCT03400917

MELANOMA

AIVITA's melanoma Phase 1B open-label, single-arm study will establish the safety of administering anti-PD1 monoclonal antibodies in combination with AIVITA's cancer stem cell-targeting immunotherapy in patients with measurable metastatic melanoma. The study will also track efficacy of the treatment for the estimated 14 to 20 patients. This trial is not yet open for enrollment.

Patients eligible for treatment will be those (1) for whom a cell line has been established, (2) who have undergone leukapheresis from which sufficient monocytes were obtained, (3) have an ECOG performance grade of 0 or 1 (Karnofsky score of 70-100%), (4) who have either never received treatment for metastatic melanoma or were previously treated with enzymatic inhibitors of the BRAF/MEK pathway because of BRAF600E/K mutations and (5) are about to initiate anti-PD1 monotherapy.

For additional information about AIVITA's AV-MEL-1 trial please visit: http://www.clinicaltrials.gov/ct2/show/NCT03743298

About AIVITA Biomedical

AIVITA Biomedical is a privately held company engaged in the advancement of commercial and clinical-stage programs utilizing curative and regenerative medicines. Founded in 2016 by pioneers in the stem cell industry, AIVITA Biomedical utilizes its expertise in stem cell growth and directed, high-purity differentiation to enable safe, efficient and economical manufacturing systems which support its therapeutic pipeline and commercial line of skin care products.

View original content to download multimedia:http://www.prnewswire.com/news-releases/aivita-biomedical-announces-publication-concerning-a-predictive-biomarker-for-melanoma-patients-treated-with-the-companys-platform-immunotherapy-300929591.html

SOURCE AIVITA Biomedical, Inc.

See the article here:
AIVITA Biomedical Announces Publication Concerning a Predictive Biomarker for Melanoma Patients Treated with the Company's Platform Immunotherapy -...

One of the biggest barriers to entry for a regular dry brushing technique is finding a brush that's right for you. Of course you'll want something that's simultaneously exfoliating, encourages lymphatic drainage, and is comforting to the touchbut that likely means different things for different people. And, thus, people will respond differently to various brush strengths. Then there's the question of shape preference: do you like a handle or something handheld? Also, if you're vegan, you'll need to opt for a synthetic or natural plant-derived option, like sisal bristles, which are made from agave fibers. Then there's where you want to be doing the dry brushing, be it your whole body, just your face, or both.

While some of these answers are obvious (face versus body, vegan versus non), some take some guessing-and-testing: You likely won't know what type of handle you like until you try, nor will you know what bristle strength you're looking for. But a good rule of thumb is beginners should default to softer bristles, as they don't know how their skin will react, while more advanced can feel comfortable experimenting with stiffer options.

Here, we gathered the best on the market, with a wide variety of variables, so you can find one that will work for you.

Go here to see the original:
9 Of The Best Dry Brushes For Head-To-Toe Exfoliation - mindbodygreen.com

The young Israeli patient I visited in the isolation room at the Dana Farber Cancer Institute in Boston in the late 1970s was very ill. Ravages of the disease and its harsh treatment were clearly evident.

Diagnosed with a uniformly terminal disease, he had traveled to this renowned center in the Longwood Medical Area to be treated with a newly developed regimen of aggressive therapy. This world-famous academic hub is the medical campus where Harvard Medical School and many of its affiliated hospitals are all located. Major breakthroughs in medicine were developed here, including the first curative treatment of leukemia, the first kidney transplant, the first use of an electrical current to restore heart rhythm. It was here that creative man leaped forward with innovative advances that saved lives.

At the time I was a post-doctoral research fellow at Harvard Medical School. Our family resided several houses from the Ravs daughters home where the Rav was living, and our Maimonides community was fortunate to be able to spend eight to ten hours with the Rav every weekend in prayer and in learning. The creative gesture so central to the Ravs philosophy of halakhic man is a prime characteristic of biomedical research, and my oscillation between the universe of cutting edge biomedical research and the world of Torah learning with the Rav, while worlds apart, was harmonious. With the Rav often expressing curiosity about aspects of my research, I began to intuit that the work might not be merely creative but in fact a religious gesture.

A central theme in the Ravs weltanschauung is his emphasis on halakhic mans creative gesture. Ish haHalakhahs mission and continuous challenge are to heal and repair a purposely flawed world, for in the creation process a modicum of chaos was formed prior to the worlds creation and deliberately injected into both organic and inorganic matter, including into man himself.[1]

Man himself symbolizes, on the one hand, the most perfect and complete type of existence, the image of God, and, on the other hand, the most terrible chaos and void to reign over creation.[2] In order to enable man to cope with his inexorable chaos and sin, the tool of repentance was also created prior to the worlds formation (Pesahim 54a).

In a reference to creative introspection in Eight Chapters, Maimonides states: The perfect man needs to inspect his moral habits, weigh his actions, and reflect upon the state of his soul every single day. Whenever he sees his soul inkling toward one of the extremes, he should rush to cure it and not let the evil state become established (chap. 4).

Max Scheler, an early proponent of positive creative repentance, points out that modern philosophy, on the other hand, sees in retrospection and repentance mostly a negative, superfluous, uneconomical act due to disharmony of the mind and ascribed to lack of thought, sickness or various illusions..[3]

Emulating Maimonides, the Rav emphasizes an essential continuous remodeling, a re-creation of the sinners self as being a healthy, critically indispensable creative process. Halakhic man is engaged in self-creation, in creating a new I. He does not regret an irretrievably lost past but a past still in existence, one that stretches into and interpenetrates with the present and the future.[4]

The Ravs perspective on repentance is related to Schelers definition of creative repentance and to Henri Bergsons distinction between subjective, qualitative time-perception versus chronos, quantitative objective time. Both Scheler and Bergson ascribe to the principle of memory and experiential plasticity. The concept of plasticity, the property of being easily molded and remolded, has received intense scientific attention in the last decade, especially as related to the field of memory and neuroscience.

The presumed inability of the brain to generate new cells or to establish new neural networks is currently vigorously challenged and has indeed been proven incorrect. The process by which man can modify imprinted memories to affect his present and future behavior pattern is currently under scientific investigation. Epigenetic biochemical modifications of DNA and changes in neural networks triggered by ongoing experiences have been documented to alter both content and intensity of memories. The association between past triggering stimuli and the resurfacing of memories and behavior patterns has been shown to be moldable utilizing imaging and histological techniques. Previous memories can be reinforced, intensified, modified, or completely erased.

We no longer look at our genetic makeup and the mature brain as a fixed template that predicts our phenotype, and no longer are our memories an unalterable code. Rather, increasingly, biochemical data support the idea that they are templates upon which environmental and emotional stimuli can impact. Biochemical changes in the brain triggered by environmental and behavioral patterns were identified in identical twins raised in different environments. Scientists have defined conditions in which terminally differentiated cells, such as mature skin cells, which we assumed could never return to their embryonic pluripotent stem-cell status, have in fact definitively reverted and reprogrammed to evolve into new cell types. Recent reports have described the astonishing generation of live mice from skin cells reengineered to be ova.

If cells can revert to their embryonic state, if gene expression can be reprogrammed, if the brain can generate new nerve cells and establish new neural networks, the view of repentant man as a biologically defined new self is viable.

David Anderson from the California Institute of Technology describes a fascinating neuro-anatomical observation. The center in the brain that orchestrates emotion is the amygdala. It communicates with the hypothalamus, which houses the cells that control instinctive behavior like parenting, feeding, mating, fear, and fighting. Anderson found that a nucleus of cells within the hypothalamus contain two distinct populations of neurons: one that regulates aggression and one that regulates mating. About 20 percent of the cells in this nucleus are active both during mating activity and during aggressive behavior, which suggests that these two circuits are linked. How does the brain regulate these mutually exclusive behavior patterns? Anderson found that depending on the specific stimuli applied to this area it can trigger either mating activity or aggression.

Perhaps creating a new self through repentance from love (On Repentance, pp. 163) is associated with using mechanisms previously utilized for aggression and fear for productive activity such as love and fertility. A similar idea is found in the Babylonian Talmud (Shabbat 156a): He who is born under Mars will be a shedder of blood. Rabbi Ashi said: Either a surgeon, a thief, a slaughterer, or a circumciser. Through biochemical processes induced by the intense experiences of the teshuvah process confession, sacrifice, remorse, shame and a commitment to a new I a new self can emerge.

* * *

A decade after I visited the seriously ill young man at the Dana Farber Cancer Institute, the facility where chaos reigns and where creative man is faced with overwhelming challenges, I attended a scientific conference in Tiberias, burial place of Maimonides. I learned that a daily minyan was available at a nearby archeological site of an ancient synagogue on the shores of the magnificent Sea of Galilee. I was welcomed by a group of yeshiva students from Bnei Brak who had been coming weekly to maintain a minyan at this historical site.

Following services I was approached by a bearded man, who inquired:Are you Dr. Goldberg?

Since I had never practiced medicine in Israel I was surprised to be addressed as a physician.

Do you remember me? he asked. I am that patient you visited at the Dana Farber so many years ago. I am healthy, married and have several children.

The Prophets and the Torah as well recognized a strong connection between sin and illness on the one hand and between repentance and healing on the other (On Repentance, p. 80).

Through the creative gesture both the body and the spirit can be remodeled and healed.

Notes:

1. See Rabbi Joseph B. Soloveitchik, Halakhic Man (Philadelphia, 1983), p. 102.

2. Halakhic Man, p. 109.

3. Max Scheler, On the Eternal in Man (New Brunswick, NJ, 2010), p. 36.

4. Halakhic Man, p. 113.

View original post here:
On creativity, plasticity and repentance - Arutz Sheva

LAS VEGAS: Can a skincare line actually have an impact on self-esteem, emotional wellbeing and even your sense of belonging? haia (Happy as I Am) - the new gender neutral, 360-degree wellness skincare line that industry leader, Michael Bruggeman, is debuting at ISPA 2019 - aims to do exactly that by going more than just skin deep.

A 2018 CDC study found suicide is at its highest rate in the U.S. in half a century. According to the World Health Organization, 300 million people have been diagnosed with depression. According to stopbullying.gov, 1 in 4 students have experienced bullying. Bruggeman decided to offer help from the outside in, via the industries he knows the best - skincare and wellness.

Ten years ago, he co-founded the first natural, professional spa brand for men, OM4 MEN, Organic Male, this year he founded the charitable foundation and leadership Institute, One Well World and four years ago, he became chair of the Global Wellness Institute's Beauty Meets Wellness Initiative.

Bruggeman couldn't help but notice a recurring theme when he conducted international roundtables with industry stakeholders in New York, London, Paris, Los Angeles and Hong Kong; when he spearheaded a Global Consumer Insights Study; and when he attended wellness summits around the world. People yearned to feel good about themselves - no matter their size, shape, race, gender or sexual proclivity - and be confident in who they were. And then there's the happy reality that natural, eco-conscious and clean products are the fastest growing segment in skincare and beauty. That kind of feedback inspired Bruggeman's decision to create haia.

Since beauty and belonging are such cultural drivers, our goal was to create a clean and inclusive skincare brand to help change the idea of living up to the social norm, explains Bruggeman, and remind you to love exactly who you are every day. And what better place to debut it than the spa & wellness industry's annual trade show & conference?

The recipe

Ingredients Using biomimicry from four different biomes - or large, naturally occurring habitats, such as a forest or tundra - he worked with some of the most sophisticated raw material manufacturers in the world to create products containing the latest in clean, nature-derived, active ingredients, such as extremophiles (microorganisms that live in conditions of extreme temperature, acidity, alkalinity, or chemical concentration), mesonutrients (the active compounds or antioxidants within superfoods found in longevity-inducing Blue Zone diets), plant stem cells and bioferments that promote a healthy skin microbiome.

Eco Certified/Cosmos Organic Beyond simply choosing organic ingredients, Bruggeman made a decision to work towards having haia qualify for Cosmos Organic, globally recognized as the highest level of organic and natural product certification that exists.

Collections The new line is divided into five different, color-coded collections with cleansers, toners, serums, moisturizers exfoliators, eye products and masks. The packaging uses a woven fabric design as a metaphor for weaving a single thread - standing for diversity and individuality -- into a fabric of strength and a work of art.

Affirmations, App & Animation - an April 2017 PSYCHOLOGY TODAY article by Dr. Leena Guptha said people can learn to incorporate self-affirmation into their arsenal of tools for coping with everyday threats and thus become agents in the maintenance of their own well-being. Each haia product has its own carefully selected affirmation such as I am Confident, I am Bold, and I am Worthy, I am Whole, I am Resourceful and I am Resilient.

Customers will be encouraged to access the industry's first ever animated skincare app on the haia website, which will have practical suggestions for implementing daily affirmations into everyday life. The app also features a virtual selfie derm-analysis that will give users personalized recommendations for product selection and use.

The animated characters not only reflect the skincare line's diverse target audience, but they can help take the pressure off spa and retail sales teams by providing a user-friendly and fun way for consumers to discover the regimen that is best for them.

Bruggeman adds, haia brings together the best of science and nature but beyond that, our hope is that the product design will make something as basic as your daily skincare routine inspire confidence, self-esteem and a sense of belonging.

Excerpt from:
haia Happy as I Am, Clean, Inclusive Skincare Brand Previews at ISPA 2019, Business World#224553 - New Kerala

Keith Swayne has a magic touch when it comes to fundraising.

I guess I could go to anyone and get them to write some kind of check just so I would go away, he says, laughing. However, thats not what I want to accomplish. I want to connect people to causes and needs that they can relate to and then help them find a way to help out.

Swayne is so adroit at soliciting donations, in fact, that a campus project he undertook has left people shaking their heads in amazement: His efforts led to a $20 million windfall for investigators at the UCI Institute for Memory Impairments and Neurological Disorders.

Keiths passionate commitment to supporting our research has been tireless and nothing short of transformative, says Joshua Grill, director of UCI MIND.

It all started with a $150,000 gift the Laguna Beach philanthropist made to the research facility in honor of his late wife, Judy, whom he lost to Alzheimers disease in 2014. He also issued a challenge to the community at the time that boosted the donation to $300,000.

The UCI MIND team then leveraged that seed money to secure a total of $20 million in funding from the National Institutes of Health.

Our research is blazing new trails into understanding the genetic, molecular and cellular underpinnings of disease and is poised to lead to identification of new treatment targets and candidates, Grill says. Keiths initial challenge-gift enabled an exponential impact in terms of research support.

Weian Zhao lab at Sue and Bill Gross Stem Cell center at UCI. Lab personnel: Ling Shun, Meglu Han, Michael Toledano, Aude Segaliny, Jan Zimak, Leanne Hildebrand

His late wife would have liked that, Swayne says. The fact that some good came from this terrible disease Judy would certainly want that, he says. And I wanted that too.

The couple, married 50 years, were best friends and committed partners. Judy Swayne, like her husband, was intent on making a difference in her community. Among other contributions, in 1989, she founded the Orange County Community Foundation, which became a major philanthropic institution in the region. Keith Swayne has carried on her legacy as a member of its board, stepping down in September after a stint as chairman.

In addition, Judy Swayne served on numerous nonprofit boards, acted as a role model and mentor to many throughout the philanthropic community, and was the mother of two: a daughter, Anne Keir, who lives in Hawaii, and a son, Kirk Swayne, of Orange County.

The disease was hard on my kids, Keith Swayne says. Its a tough disease.

It was also hard on Swayne himself, Grill notes: Alzheimers is an insidious disorder that robs patients of their most human characteristics language, decision making and, of course, memory.

Ultimately, it also robs patients of their independence, putting a strain on family members.

Keith was a caregiver to his beloved Judy, a costly and taxing role, Grill says. He watched her progress until she succumbed to this unrelenting disease, helpless to do anything to slow or stop its course. He decided to do what he could to prevent others from suffering her fate.

Frank M. LaFerla, dean of the UCI School of Biological Sciences, also recalls Swaynes struggles.

Alzheimers disease really impacted his family, he says. Judy was a very special woman. He wanted to make sure future generations wouldnt experience the pain his wife did.

At the time, LaFerla was director of UCI MIND and talked with Swayne about ways he could make a difference in the search for a cure. One field of research involved stem cells, which experts believe may offer great promise for new medical treatments.

My lab had started getting involved with stem cells many years ago, and about this time a new technology was created using stem cells from your skin, not embryos, LaFerla says. You could take some of a patients skin cells by biopsy and reprogram them to become pluripotent meaning they have the ability to give rise to many different types of cells found in the body, such as brain cells or more skin cells or kidney cells.

Swayne likes innovation and taking chances, LaFerla says: I told him this opportunity was high-risk but had high potential.

That was when Swayne issued his challenge to the community and set about rounding up donors. He held salons at his hillside home, inviting LaFerla and other UCI staffers to speak to local residents. They explained how pluripotent stem cell technology could be used as a tool in Alzheimers research.

I went to people who knew my wife or to people I knew who also had a vested interest in Alzheimers research because they had the disease in their own families, Swayne says.

He found many community members who were willing to contribute.

The odds are that if you live to be 85, theres a 1-in-2 chance youre going to have Alzheimers. A lot of my friends are in my age bracket, says Swayne, 79. The message was compelling.

One thing he learned was that individuals were familiar with the Alzheimers Association but not UCI MIND.

In some respects, UCI MIND is one of the best-kept secrets in Orange County, Swayne says. Many people didnt know that its one of only 30 NIH-designated Alzheimers research centers in the country.

His fundraising zeal and efforts to involve the Orange County community in the effort eventually paid off. As LaFerla says, It worked better than we could ever have dreamed.

When the time came to renew funding for the stem cell research program from the National Institute on Aging, UCI MIND won a five-year commitment to continue its research. One reason behind the NIAs decision: local philanthropic contributions.

With charitable and federal funding in place, UCI established a bank of induced pluripotent stem cells, now a valuable resource for Alzheimers researchers globally. Today, hundreds of cell samples have been provided to investigators at UCI and 10 other research universities around the world, and UCI MIND scientists and their partners have received more than $20 million in grants.

And all of that stemmed, ultimately, from the initial gift we received from Keith, LaFerla says.

Adds Swayne: We grew $150,000 to $20 million. It blows me away.

Hes not resting on his laurels, though. Swayne continues to connect more donors to UCI MIND so that research can progress.

The UCI MIND team is devoted to this cause, he says. Its reassuring to know youve got people with this talent trying to find answers to this disease.

So Swayne writes letters to business and community leaders urging their backing, chairs a panel that seeks new opportunities for philanthropic gifts, speaks on behalf of the institute at public events, and co-leads a caregiver support group for men whose spouses have Alzheimers.

Keith gives a voice to the nearly 6 million Americans with Alzheimers and the more than 15 million caregivers like him, Grill wrote earlier this year in a letter nominating Swayne for the Outstanding Philanthropist Award, which will be conferred on Nov. 14 by the Association of Fundraising Professionals of Orange County in celebration of National Philanthropy Day. UCI MIND would not be the organization it is without the leadership of Keith Swayne.

The rest is here:
Stemming the Tide of Alzheimer's - UCI News