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Archive for the ‘Gene Therapy Research’ Category

Movies for the human genome

Story Summary: This is the resource that researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and their collaborators in the Mitocheck consortium are making freely available, as the result of a study in which they have identified the genes involved in mitosis – the most common form of cell division – in humans. Published today in Nature, their work begins to unravel the molecular workings of one of the most fundamental processes of life: how one cell becomes two. The end result is that we now have a very rich resource for the scientific community, as were making all the movies and all the analysis data freely available online, Ellenberg emphasises: Scientists can go to the website, type in the name of their favourite gene, and watch what happens when it is silenced; they can find out what other genes have similar effects – all in a few mouse clicks, instead of months or years of work in the lab!But mitosis is not solved yet, the scientists say. They have yet to uncover exactly how these genes act at the molecular level – a task which will be tackled by a follow-up project called Mitosys. A year after we developed these new siRNA microarrays, says Rainer Pepperkok, who led the methods development at EMBL, theyre already in use by over 10 research groups from across Europe….Read the Full Story

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  1. Scientists decipher the 3-D structure of the human genome
  2. Faster, cheaper way to find disease genes in the human genome passes initial test
  3. Faster, cheaper way to find disease genes in human genome passes initial test

454 Sequencing Study Unravels the Hidden Genomic Complexity of the Giant Mimivirus

Story Summary: Previous studies have shown that unlike most viruses, the Mimivirus has more genes than many bacteria and performs functions that normally occur only in cellular organisms. The results of the most recent study, led by a team from the Structural and Genomic Information Laboratory at the Mediterranean Institute of Microbiology in Marseille, France, suggest that the Mimivirus is even more complex than previously thought. In a quest to fully characterize the Mimivirus transcriptome and obtain new insights into its gene and protein functions, the researchers turned to the Genome Sequencer FLX System. Sequence mapping also allowed the precise delineation of most promoter regions and the identification of the sequence motif governing the early versuslate expression of Mimivirus genes. We are pleased to see continued widespread adoption of 454 Sequencing systems in virology research, said Ulrich Schwoerer, Head of Global Marketing at 454 Life Sciences. We are excited to follow the teams continued work in this field. About RocheHeadquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the worlds largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roches personalised healthcare strategy aims at providing medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients. In 2009, Roche had over 80000 employees worldwide and invested almost 10 billion Swiss francs in R&D. The Group posted sales of 49. (1) Legendre et al. mRNA Deep Sequencing Reveals 75 New Genes and a Complex Transcriptional Landscape in Mimivirus. 454, 454 LIFE SCIENCES, 454 SEQUENCING, and GS FLX are trademarks of Roche….Read the Full Story

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  1. Researchers to Decode Antarctic Ice Metagenome with the 454 Sequencing System, to Explore the Effects of Climate Change
  2. The Research Institute of the Hospital Universitari Vall dHebron is the first Spanish Health Centre to Acquire High-Performance Sequencing Technology of 454 Life Sciences
  3. Norwegian Team Completes Cod Genome Using 454 Sequencing System

Research and Markets: Genetic Counseling Practice: Advanced Concepts and Skills

Story Summary: Research and Markets: Genetic Counseling Practice: Advanced Concepts and Skills Genetic Counseling Practice: Advanced Concepts and SkillsThe first advanced-level genetics counseling skills resource As genetic medicine and testing continue to expand, so the role of the genetic counselor is transforming and evolving. Genetic Counseling Practice: Advanced Concepts and Skillsis the first text to address ways that genetic counselors can deepen their skills to meet expanding practice demands. This timely resource not only helps readers further develop their abilities to gather relevant data and interpret it for patients, it also aids them in surpassing their usual role by truly understanding patient situations, incorporating patient values into clinical practice, providing in-depth support, and facilitating thoroughly informed, autonomous decisions. In addition, oncology nurses, social workers, and psychologists working with genetic counseling patients and families; medical geneticists and physicians training in the field; and physician assistants will also benefit from this resource. Key Topics Covered:Genetic Counseling Dynamics 1) Introduction (Patricia McCarthy Veach, Bonnie S. LeRoy, and Dianne M. Bartels). 2) Complicated Shadows: A Critique of Autonomy in Genetic Counseling (Robert G. Resta). 3) Actively Engaging with Patients in Decision-Making (Andrea Zanko and Michelle Fox). 12) Genetic Counseling for Women with Intellectual Disabilities (Brenda Finucane). 13) Genetic Counselors: Caring Mindfully (June A. Peters)….Read the Full Story

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  1. Some Social Skills May Be Genetic
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  3. Study Shows Key Role Environment Plays In Developing Reading Skills

New brain nerve cells key to stress resilience, UT Southwestern researchers find

Story Summary: New brain nerve cells key to stress resilience, UT Southwestern researchers findUT Southwestern Medical Center researchers have found new clues that might help explain why some people are more susceptible to stress than others. Specifically, the cells that these animals produced after a stressful event survived longer than new brain cells produced by mice that were more resilient. The study is the first to link the memory of a social experience with neurogenesis in the hippocampus, Dr. Eisch said. In this study, Dr. Eisch and her colleagues exposed some mice to social defeat by having the animals live in the same cage as larger, aggressor mice for five minutes a day, and in the same cage but with a barrier in place the rest of the day. Researchers then tested the mice to see if they were susceptible to stress. The researchers labeled the new cells of susceptible and unsusceptible mice so they could see how the cells divided. Both types of mice produced fewer dividing cells immediately after stress, but in the long run, mice susceptible to stress had more new adult cells than unsusceptible and control mice, who lived in cages with nonaggressor mice. Dr. Eisch and her colleagues also used radiation to prevent hippocampal neurogenesis in all groups of mice. We are very eager to see if these results carry over to other models of stress in animals and to explore the mechanisms underlying these changes, as these are critical steps to understanding how adult-generated neurons might be modulated to help humans in stressful situations….Read the Full Story

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  2. Childhood stress genetically alters kids to be stressed-out adults
  3. Nerve cells regenerate brain (ScienceAlert)

Simplifying complexity — new insights into how genomes work

Story Summary: com) — A genome is a complex system of genes and factors that regulate them. A European research team has clarified how such dynamic systems work, leading to a new way to predict genetic regulators. Their findings promise to boost research into the functioning of genetic networks in general, and into the dynamics of the human genetic system in health and disease. Decades of research have shown that the resulting patterns of gene expression direct a cell or organisms development, normal functioning, and responses to environmental challenges. Trolling for transcription factorsUntil now, the most effective way researchers had to try to match genes and provisional transcription factors was to look for short DNA sequences that were known to bind to specific regulatory molecules. Doing it with a pipette takes a long time and costs a lot of money, says Kepcs. The GENNETEC team decided to address that problem by studying a new and independent way to predict whether a gene is controlled by a particular factor. They suspected that this periodic spacing is related to the way that DNA coils up inside the nucleus of a cell, and serves to optimise the functioning of related genes and transcription factorsby grouping them geographically. Scientists are always more comfortable if they understand the mechanism that produces an observed regularity. What we discovered is that there is a clear link between chromosome structure and gene expression, says Kepcs, a link that we can now predict in a very precise and workable way. Faster, more focused searchWhen the GENNETEC team combined their new positional predictor with the standard sequence predictor, they found that they could identify new gene-regulator relationships far more efficiently. Combining the two predictors allows us to predict the regulators of a particular gene much better, by cutting down on the false hits, says Kepcs. One of the consortium partners, NorayBio, based in northern Spain, is developing a commercial software package that will allow researchers worldwide to apply this more powerful approach to deciphering genetic networks. While Kepcs is pleased with this new research tool, he emphasises that the consortiums fundamental research on complex systems is equally important. Cells have just one genome, but with that one genome they can cope with multiple challenges, says Kepcs. We can use this biological solution as inspiration to make a new generation of algorithms to address complex problems better than before. The system is apparently controlled by a key protein that the researchers have named NINJA….Read the Full Story

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  1. Insights into the evolution of the snail superfamily from metazoan wide molecular phylogenies and expression data in annelids – 7thSpace Interactive
  2. Scientists 3-D view of genes-at-work is paradigm shift in genetics
  3. J. Craig Venter Institute Researchers Clone and Engineer Bacterial Genomes in Yeast and Transplant Genomes Back Into Bacterial Cells