Archive for the ‘Cell Therapy’ Category

Princess Margaret Cancer Program will implement ComprehensiveBMT and Investigate Cell Therapy to continue leading role in cancer care and research

SALT LAKE CITY , Nov. 14, 2012 /CNW/ - Remedy Informatics, the leading provider of registries and research informatics software for Life Science and Translational Research and Healthcare, today announced the Princess Margaret Cancer Centre at University Health Network in Toronto has selected ComprehensiveBMT and Investigate Cell Therapy, two of Remedy's innovative clinical informatics solutions.

(Logo: http://photos.prnewswire.com/prnh/20120206/SF47874LOGO)

"The Princess Margaret is one of the largest comprehensive cancer facilities in the world with the largest Blood and Marrow Transplant program in Canada and a gold standard cancer research facility," said Gary Kennedy , Founder and CEO of Remedy Informatics. "Both InvestigateCT and ComprehensiveBMT offer unmatched integration of information to improve treatment outcomes by aggregating, mapping, harmonizing and analyzing data across clinical and scientific disciplines. Valuable information will give valuable insights into patient safety, patient survivorship, and quality improvement for transplant physicians, nurses and researchers."

Built on Remedy's flagship Mosaic Platform, InvestigateCT and ComprehensiveBMT offer the Princess Margaret the world's first and only truly integrated research management system. In addition to combining blood and marrow registries with cell therapy laboratories and biobanks, clinicians and researchers will have an unprecedented view of their data through the Mosaic Ontology, which aggregates, maps and harmonizes the data to facilitate pattern recognition. Together researchers are able to manage and aggregate more data sources, across disciplines, including next-generation sequencing, cross-disease registries, LIMS and the Blood and Marrow Transplant Program to advance research of cell therapies, blood and marrow transplantation, and related diseases.

"The future of patient care and innovative research in blood and marrow transplantation requires rapid data analysis to track and improve patient outcomes. We are confident Remedy Informatics can meet our needs," said Dr. John Kuruvilla , MD, FRCP(C), director, Clinical Program, Blood and Marrow Transplant program at the Princess Margaret . "We foresee better information management as the cornerstone for improving patient outcomes in hematologic malignancies."

The Princess Margaret BMT program has an international reputation as a global leader in clinical and research programs and as a gold standard in transplant technologies like Apheresis collections for peripheral stem cell transplant infusions and Extracorporeal Photopheresis for selected graft-vs-host conditions. Over the next year, Remedy will work with the Princess Margaret BMT program to implement InvestigateCT, the world's first Integrated Research Management System designed for cancer centers involved in clinical research using cell therapies. InvestigateCT will facilitate multi-directional data flow throughout the BMT program, cell therapy labs and biobanks to improve real-time analytics, therapies, patient safety, and quality across the transplant care pathway as well as long-term patient survivorship for patients who are living longer and healthier lives.

Remedy serves a wide range of leading Life Science and Translational Research institutions across the country, including the Huntsman Cancer Institute at the University of Utah, Cleveland Clinic's Bariatric and Metabolic Institute and Heart and Vascular Institute, the American Joint Replacement Registry, Baylor Health Care System, and many more.

For more information about Investigate Cell Therapy or ComprehensiveBMT, or Remedy's leading patient registry technology, please visit our website, http://www.remedyinformatics.com. InvestigateCT is for research use only and is not intended for clinical or cell processing purposes.

About Remedy Informatics, Inc.

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The Princess Margaret BMT Program Chooses Remedy Informatics' Blood and Marrow Transplant & Cell Therapy Solutions to ...

What Are Stem Cells | Stem Cell Malaysia
stemcellmalaysia.com Stem cells are non-differentiated cells with the ability to divide and produce any body cell types. The ability of stem cells to differentiate and self-regenerate impart great possibilities for disease treatment other than for restoring health, beauty and anti-aging. Clinically proven for certain illness and conditions, stem cells can now be introduced into the body to repair and replace damaged organ or tissue. For more informative articles on stem cells and stem cell therapy, please visit Stem Cell Malaysia at http:/stemcellmalaysia.com/.From:stemcells2012Views:2 1ratingsTime:06:29More inHowto Style

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LITCHFIELDWith a name inspired by a Celtic goddess who could manifest magic for the good of others, an Elkhound mix that suffered the depths of animal abusenearly to the point of deathis benefiting from cutting-edge veterinary medicine at a practice in Bantam.

Rhiannon, whose name derives from the Stevie Nicks song about the legendary goddess, is one of two patients helping to make veterinary history in Connecticut through the states first in-clinic stem cell regenerative therapy treatments.

Such loving care stands in stark contrast to the condition Rhiannons owner, Edward Milne of Cheshire, found the 14-year-old in the first time he saw her.

I found her hanging by her neck from a tree as I was driving along a back country road in Northford, CT when she was about two years old, Mr. Milne wrote in an e-mail to the Bantam clinic, Animal Health Practice Inc.

When I confronted the owner, Mr. Milne wrote, he admitted that he had not fed her or provided her with water for some time, and when she didnt die, he hung her from the tree to finish her off. I guess it was fate that brought us together.

Another type of Rhiannon-esque fate brought the dog to a vet who is performing a ground-breaking procedure to treat severe arthritis in her elbow and back.

Rhiannon is the first dog to receive MediVet Americas non-controversial adipose regenerative stem cell therapy, according to a release sent by the company. MediVet is a global leader in veterinary science located in 29 countries. The company develops advanced cellular treatments and natural herbal remedies designed to maximize animal performance, repair, recovery and general wellness.

Were very excited to be the first veterinarians in Connecticut to offer this new technology, said Dr. Angela Erickson-Greco Monday morning.

In addition to Rhiannon, Dr. Erickson-Greco is also administering the treatment to Dakota, a Bernese Mountain Dog and Great White Pyrenees mix, who has bilateral ACL tears, which means she has torn a crucial ligament in both of her knees.

New Milford resident Cathy Morsey said Dakota had a limp in her front leg in the shoulder area at 6 months old. In January of last year, we had a wet snow and she slid on the snow and tore a cartilage in her knee, said Ms. Morsey. Continued...

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Rhiannon, an Abused Dog, and Dakota, Get Stem Cell Therapy in Litchfield

JERUSALEM--(BUSINESS WIRE)--

Gamida Cell Ltd., a world leader in stem cell population expansion technologies and stem cell therapy products for transplantation and regenerative medicine, announced today that the first patient, enrolled in its pilot study of NiCord as an investigational treatment for sickle cell disease (SCD), has been transplanted at Duke University in North Carolina.

Gamida Cell CEO Dr. Yael Margolin said, The NiCord study is a first step in broadening Gamida Cells pipeline of cell therapies to treat patients who suffer from severe non-malignant diseases with a very large unmet clinical need.

SCD is a group of inherited red blood cell disorders where red blood cells become hard and sticky and look like a C-shaped farm tool called a sickle. According to statistics, SCD affects 90,000 to 100,000 in the US alone, mainly African-Americans and Hispanic-Americans. Symptoms range in type and severity. SCD can be fatal and to date, the only cure for SCD is stem cell transplantation from a family related matched donor.

Dr. Margolin continued, Sickle cell disease can be cured with a successful bone marrow transplantation, especially from a family related fully matched donor. Most patients do not pursue this option, since they do not have the suitable donor. NiCord is intended to reverse this situation and provide a readily available cure.

NiCord is an expanded cell graft derived from an entire unit of umbilical cord blood and enriched with stem cells. NiCord was developed based on Gamida Cells proprietary NAM technology.

The official name of the study is Allogeneic Stem Cell Transplantation of NiCord, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, in Combination With a Second, Unmanipulated Cord Blood Unit in Patients With Sickle Cell Disease. http://www.clinicaltrials.gov/ct2/show/NCT01590628?term=nicord&rank=1. A total of 10 patients, ages 2 21, will be enrolled in the NiCord study, a single center, single arm trial evaluating the safety and efficacy of transplanting NiCord together with a second un-manipulated cord blood unit in patients with SCD following myeloablative therapy. The study will also assess transplant-related mortality, event-free survival and overall survival at 100, 180 and 365 days, respectively.

About Gamida Cell

Gamida Cell is a world leader in stem cell population expansion technologies and stem cell therapy products for transplantation and regenerative medicine. The companys pipeline of stem cell therapy products are in development to treat a wide range of conditions including blood cancers, solid tumors, non-malignant hematological diseases such as hemoglobinopathies, neutropenia and acute radiation syndrome, autoimmune diseases and metabolic diseases as well as conditions that can be helped by regenerative medicine. Gamida Cells therapeutic candidates contain populations of adult stem cells, selected from non-controversial sources such as umbilical cord blood, bone marrow and peripheral blood, which are expanded in culture. Gamida Cells current shareholders include: Elbit Imaging (EMITF), Clal Biotechnology Industries (CBI.TA), Israel Healthcare Venture, Teva Pharmaceutical Industries (TEVA), Amgen, Denali Ventures and Auriga Ventures. For more information, please visit: http://www.gamida-cell.com.

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First Pediatric Sickle Cell Disease Patient Receives NiCord® Stem Cell Transplantation in Gamida Cell Pilot Study at ...

123Triad : wwmsbiologicscom
123Triad is proud to design website for http://www.wwmsbiologics.com WorldWide Medical Services Inc. is a company that for more than 10 years is dedicated to utilizing the most innovative technologies to provide its clients with the highest quality services. Worldwide Medical Services specializes in the Intra-operative treatment of surgical patients. One of their most exciting new products is platelet gel and adult stem cell therapy services which can be provided in a hospital or office setting. their Autotransfusion service is available 24/7 on a scheduled or emergency basis.From:123triadcoViews:7 0ratingsTime:00:36More inScience Technology

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Govt. Appoints Task Force To Explore Stem Cell Research
Minister of Health Hon. Dr. Perry Gomez announced that the government has appointed a 10 member task force, charged with making recommendations to the government to explore stem cell therapy in The Bahamas.From:ZNSNetworkViews:44 0ratingsTime:03:27More inNews Politics

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blood bank | The Development of Umbilical Cord Blood Stem Cell Therapy
http://www.cordbloodrecommendation.com Umbilical cord blood is stored immediately after delivery, when the cord is cut. Diseases that are genetically based would most likely be an allogenic transplant. Human umbilical cord blood cells are very rich in stem cells and progenitor cells which make them the perfect place to take cells from and then store them in a cord blood bank or a stem cells bank. Scientists have found that umbilical blood can actually help to treat many types of medical issues. To make a long story short, the Adult Stem Cells did the trick. This would be a significant event, which would save thousands of lives of those waiting for an organ. Why would someone opt for cord blood preservation? Well, research is continually being conducted and cells extracted from this blood has already been used to treat and cure injuries and diseases. Cord Blood Banking facilities are places where you can bank your child #39;s cord blood and use it later on in life to cure life-threatening diseases. The National Cord Blood Program staff at the New York Blood Center performs cord blood collection from the expelled placenta. Because of this amazing capacity of blood cells, they have been, still are and will continue to be used more and more to save lives and cure a number of diseases. ""Umbilical cord blood contains blood-forming cells that can be used to treat life-threatening diseases and conditions. Stem cells, researchers discovered, could cure many diseases such as leukemia and ...From:hotelesenMelgarViews:0 0ratingsTime:01:18More inScience Technology

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blood bank | The Development of Umbilical Cord Blood Stem Cell Therapy - Video

CombiCult Workflow
A overview on how Plasticell (www.plasticell.co.uk) uses combinatorial cell culture (CombiCult) to discover optimised stem cell differentiation protocols in record time, at a fraction of the cost of the status quo while reducing project return risk. CombiCult is used by our customers in a range of applications in regenerative medicine, cell therapy and research and development.From:PlasticellLimitedViews:1 0ratingsTime:06:40More inScience Technology

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Progenitor Cell Therapy For Neurological Injury
ll4.me Progenitor Cell Therapy For Neurological Injury Preface.- Chapter 1. Basics of Stem and Progenitor Cells.- Chapter 2. Progenitor Cell Tissue Engineering: Scaffold Design and Fabrication.- Chapter 3. Stem Cell Delivery Methods and Routes.- Chapter 4. Neural Stem Cells-Endogenous Repair of Neurological Injury.- Chapter 5. Traumatic Brain Injury: Pathophysiology and Models.- Chapter 6. Traumatic Brain Injury: Relationship of Clinical Injury to Progenitor Cell Therapeutics.- Chapter 7. Cell-Based Therapy for Stroke.- Chapter 8. Spinal Cord Injury: Pathophysiology and Progenitor Cell Therapy.- Chapter 9. Current Status of Clinical Trials using Progenitor Cells for Neurological Injury EAN/ISBN : 9781607619659 Publisher(s): Springer, Berlin, Springer Science Business Media Discussed keywords: Neurologie, Zelltherapie Format: ePub/PDF Author(s): Cox, Charles S. Preface.- Chapter 1. Basics of Stem and Progenitor Cells.- Chapter 2. Progenitor Cell Tissue Engineering: Scaffold Design and Fabrication.- Chapter 3. Stem Cell Delivery Methods and Routes.- Chapter 4From:dorethacopeland98549Views:0 0ratingsTime:00:14More inPeople Blogs

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Progenitor Cell Therapy For Neurological Injury - Video

Stem Cells | Stem Cell Malaysia
stemcellmalaysia.com Stem cells are cells which have the potential to develop into virtually any cells of the body. The characteristics of stem cells render them great possibility in treating illness as well as health rejuvenation. Stem cells can repair and renew damaged cells as well as replace the dead ones so that a damaged organ or tissue can be healed to its healthy state. Visit Stem Cell Malaysia at http:/stemcellmalaysia.com/ for more information on stem cells and stem cell therapy.From:stemcells2012Views:262 2ratingsTime:06:33More inHowto Style

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Stem Cells | Stem Cell Malaysia - Video

Stem Cell Research and TNG
How close is Science to providing visors for the blind? Or what about curing blindness? Have you watched the episode "The Masterpiece Society" from season 5 of TNG? Cause I have a couple of philosophical things to say about that! An article about STEM CELL therapy in regards to vision impairment: abcnews.go.com Interview with TrekMate: http://www.trekmate.org.uk ***I feel like the Star Trek community is a lot bigger then what YouTube has to offer, so I #39;ve started uploading my own videos. A lot of you will find this painfully dorky -and it is- which is why constructive criticism is welcomed. For anyone who does like my posts, thank you! It would be nice to gather a little Trekkie community :)***From:ThatTrekkieGirlViews:6 1ratingsTime:06:51More inPeople Blogs

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25 Multiple Sclerosis Plr Articles
ll4.me 25 Multiple Sclerosis Plr Articles 25 Multiple Sclerosis Articles - Private Label Rights Article Topics:- Treatment For Multiple Sclerosis With No Side Effects Types Of Multiple Sclerosis What Multiple Sclerotic People Should Avoid during Christmas How To Diagnose Multiple Sclerosis How To Know If It Is A Multiple Sclerosis Relapse How To Treat Multiple Sclerosis Is Cannabis Use Beneficial For Multiple Sclerosis Lifesaving Drug For Multiple Sclerosis More Information On Multiple Sclerosis Multiple Sclerosis Association Of America All About Multiple Sclerosis Causes Of Multiple Sclerosis Childbirth May Slow Multiple Sclerosis Common Human Bacteria Triggers Multiple Sclerosis Good News On Pregnancy And Multiple Sclerosis How Is Multiple Sclerosis Classified The Clinical Part Of Multiple Sclerosis The History Of Multiple Sclerosis The Kurtzke Expanded Disability Status Scale And Multiple Sclerosis Multiple Sclerosis Differential Diagnoses Not Everyone With Multiple Sclerosis Is On Treatment Pathophysiology Of Multiple Sclerosis Stem Cell Therapy Reverses Multiple Sclerosis Symptoms Of Multiple Sclerosis Teenage Obesity and Multiple Sclerosis Use the content on : Blogs/Content Pages Report Social Sites ecourses Convert to Audios ebook Bundle and Sell as Products Personal Education, Tips Training Whatever you might imagine... RIGHTS:- [YES] Can Be Sold [YES] Can Be Packaged [YES] Can Be Offered As a Bonus [YES] Can Be Added As Web Content [YES] Can Be Used For Product ...From:rebeccahenson9854Views:0 0ratingsTime:00:14More inPeople Blogs

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Thelma before Stem Cell Therapy
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Thelma before Stem Cell Therapy - Video

Charles - USA Stem Cells Testimonial
If you would like more information please call us Toll Free at 877-578-7908. Or visit our website at http://www.usastemcells.com Or click here to have a Free Phone Constultation with Dr. Matthew Burks usastemcells.com Real patient testimonials for USA Stem Cells. Adult stem cell therapy for COPD, Emphysema, and Pulmonary fibrosis.From:USAStemcellsViews:4 0ratingsTime:10:04More inScience Technology

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SHIMMIAN MANILA - Celebs share good effects of stem cell therapy
From:myrenovatiosolutionsViews:1 0ratingsTime:01:30More inEntertainment

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SHIMMIAN MANILA - Celebs share good effects of stem cell therapy - Video

Published on 10 November 2012 Hits: 133 Written by Jovee Marie N. Dela Cruz

The Department of Health (DOH) on Friday said that it has become necessary to issue regulations for stem cell therapy in the country. Health Secretary Enrique Ona said that guidelines for clinics offering stem cell therapy will be released immediately by the DOH and the Food and Drug Administration.

We will issue guidelines because here in the country we dont know where the stem cell offered by clinics come from, he said.

According to the DOH, stem cell therapy belongs to the category of advanced cell therapy, which includes biologics and blood. Many countries apply a risk-based approach to assess the quality, efficacy and safety of advanced cell therapy.

In many countries, stem cell is considered an investigational intervention, Ona said.

The DOH said that stem cell research employs both autologous (from same person) or allogenic (from another organism like an animal or another human cell or tissue sample) method.

Ona said that because there are many steps in the preparation of this lab and invasive procedure, there is a need to have a regulatory framework to protect Filipino citizens.

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DOH to regulate stem cell therapy in PH

UPDATE on Stem Cell Therapy

7 November 2012

The Department of Health (DOH) saw the necessity to cover regulations for Stem Cell therapy. Stem Cell therapy belongs to the category of Advanced Cell therapy which includes biologics and blood. Many countries around the world apply a risk-based approach to assess the quality, efficacy and safety of advanced cell therapy. In many countries, Stem Cell is considered an investigational intervention.

Stem Cell research employs both autologous (from same person) or allogenic (from another organism like animal or another human cell or tissue sample) method. Because there are many steps in the preparation of this lab and invasive procedure, there is therefore need to have a regulatory framework to protect Filipino citizens.

Important questions were asked: is there proof of concept in animal trials where stem cell can then be applied in humans? Is there a way to ensure quality and purity of the raw materials? How safe is the procedure? How many did not benefit from the procedure? If this were investigational procedure, how will human subjects be protected?

Sec. Enrique Ona convened a consultative working task force to provide recommendations on how to proceed in the early part of the year in response to queries and mushrooming of centers here and overseas. This led to the creation of a regulatory task force to oversee the appropriate steps that will ensure quality, efficacy and safety documentation of this intervention.

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UPDATE on Stem Cell Therapy 7 November 2012

PRP Vs Stem Cell Therapy
PRP Therapy Vs Stem Cell TherapyFrom:MiamiFootSurgeryViews:4 0ratingsTime:01:23More inHowto Style

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Stem Cells Doctor in Mexico Shares his Expertise
http://www.mexicohealth.com The video shows a stem cells doctor in Mexico discussing various procedures he specializes in, which notably are multiple sclerosis, brain degenerative disorders, and eye sight rectification. This stem cell specialist has treated over forty patients using cutting edge stem cell therapies. Despite cynical attitudes from different quarters, this doctor represents the vanguard for stem cell treatments for progressively degenerative conditions. To read the transcript and to get a free quote from stem cells doctor in Mexico. Click the link above. Related Searches: Stem Cell Therapy Doctors Mexico, stem cell treatment glaucoma mexico, stem cell therapy brain disorders mexico, stem cell therapy brain injury mexico, stem cell treatment spinal cord MX,From:mexicohealthViews:3 0ratingsTime:04:05More inPeople Blogs

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Stem Cells Doctor in Mexico Shares his Expertise - Video

What is stem cell therapy?
What is stem cell therapy?From:MiamiFootSurgeryViews:4 0ratingsTime:00:50More inHowto Style

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What is stem cell therapy? - Video

Stem Cells Treatment in Mexico - Reports You #39;ll Need
http://www.mexicohealth.com The video shows a top stem cell specialist emphasizing the importance of reports and records in devising a sure shot stem cell treatment. Mexico is going where others have feared to tread by investing heavily in stem cell research and development. Not all conditions are curable using stem cells. Some even require a certain degree of faith in your doctor. This doctor has helped more than 40 patients to get up on their feet. Communication is the key, as this doctor points out. If you #39;re mulling over getting a stem cell treatment in Mexico, for yourself or somebody you know, always remember to carry exhaustive reports. To get a free quote, click the link above. Related Searches: stem cell therapy specialists mexico, Stem Cell Treatment for Multiple Sclerosis Mexico, Stem Cell Therapy in Mexico for Chronic Heart Failure, Adult Stem Cell Treatment in Mexico, Stem Cell Therapy for Diabetes Mexico, stem cell treatment for brain damage Mexico, Stem Cell Treatment for Neurodegenerative Conditions mexico, Stem Cell Treatment for Eye Diseases Mexico, Stem Cell Treatment for Heart Conditions Mexico, Stem Cell Therapy for Brain Injury Mexico,From:mexicohealthViews:3 0ratingsTime:02:08More inPeople Blogs

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PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version).mp4
PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version) Please contact Pearly @ +65 9338 9541 for more detailsFrom:PurtierPearlyViews:1 0ratingsTime:08:01More inPeople Blogs

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PURTIER Live Stem Cell Therapy - 4th Edition (Chinese Version).mp4 - Video

PURTIER Live Stem Cell Therapy - 4th Edition (English Version).mp4
PURTIER Live Stem Cell Therapy - 4th Edition (English Version) Please contact Pearly @ +65 9338 9541 for more detailsFrom:PurtierPearlyViews:1 0ratingsTime:09:00More inPeople Blogs

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PURTIER Live Stem Cell Therapy - 4th Edition (English Version).mp4 - Video

Public release date: 6-Nov-2012 [ | E-mail | Share ]

Contact: Steve Goodyear sgoodyear@mhif.org 952-807-8365 Minneapolis Heart Institute Foundation

MINNEAPOLIS, MN November 6, 2012 Administering autologous stem cells obtained from bone marrow either 3 or 7 days following a heart attack did not improve heart function six months later, reports a new clinical trial supported by the National Institutes of Health. The results of this trial, called TIME (Transplantation In Myocardial Infarction Evaluation), were presented by Jay Traverse, MD of the Minneapolis Heart Institute Foundation Tuesday, Nov. 6, at the 2012 Scientific Sessions of the American Heart Association in Los Angeles.

The results of this trial mirror a previous, related study (LateTIME) which found that autologous bone marrow stem cell therapy given 2-3 weeks after a heart attack did not improve cardiac recovery. Both TIME and LateTIME were carried out by the Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the NIH's National Heart, Lung, and Blood Institute.

"The data presented by TIME do much to advance stem cell therapy research," said Jay Traverse, MD of the Minneapolis Heart Institute Foundation and Principal Investigator of this study. "While this study did not provide a demonstrated cardiac benefit after six months, we still learned a great deal. Together, TIME and Late TIME have shown that stem cell therapy is safe, and they have set a baseline in terms of quantity of stem cells, type of stem cells, and severity of heart attack."

TIME enrolled 120 volunteers (avg. age 57) between July 2008 and February 2011; the participants all had moderate to severe impairment in their left ventricle and had undergone coronary stent placement as treatment for the heart attack. The participants were randomly assigned to one of four groups: day 3 stem cell, day 3 placebo (inactive cells), day 7 stem cell, or day 7 placebo. The CCTRN researchers developed a method of processing and purifying the stem cells from the bone marrow of each volunteer to ensure everyone received a uniform dose (150 million stem cells).

Heart improvement was assessed six months after stem cell therapy by measuring the percentage of blood that gets pumped out of the left ventricle during each contraction (left-ventricular ejection fraction, or LVEF). The study found no significant differences between the change in LVEF readings at the six month follow-up in either the Day 3 or Day 7 stem cell groups compared with placebo or with each other; every group showed about a 3 percent improvement in LVEF. However, the researchers found that younger patients randomized to Day 7 had greater improvement in their LVEF compared to their placebo counterparts

"The lack of six-month improvement seen for TIME and, prior to that, LateTIME, does not mean stem cell therapy is not a viable post-heart attack strategy," said Traverse. "Because we have this data we can start to address some parameters; for example this therapy may work better in younger people, or maybe we need to use cells from healthy volunteers (allogeneic) since their cells may provide greater therapeutic benefit. There will also be upcoming studies using novel cell types which we look forward to using in future clinical trials."

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Stem cell therapy using patient's own cells after heart attack does not enhance cardiac recovery

Public release date: 6-Nov-2012 [ | E-mail | Share ]

Contact: Jill Scoggins jill.scoggins@louisville.edu 502-852-7461 University of Louisville

LOS ANGELES Marked sustained improvement in all patients with zero adverse effects.

For a phase I clinical trial, these results are the Holy Grail. Yet researchers from the University of Louisville and Brigham and Women's Hospital today reported just such almost-never-attained data.

In a Late-Breaking Clinical Trial session at the American Heart Association Scientific Sessions 2012 meeting, Roberto Bolli, M.D., of the University of Louisville and Piero Anversa, M.D., of Brigham and Women's Hospital, Boston, presented data from their groundbreaking research in the use of autologous adult stem cells with patients who had previous heart attacks.

They report that after two years, all patients receiving the stem cell therapy show improvement in heart function, with an overall 12.9 absolute unit increase in left ventricular ejection fraction (LVEF), a standard measure of heart function that shows the amount of blood ejected from the left ventricle during a heartbeat. No adverse effects resulting from the therapy were seen. Moreover, MRIs performed on nine patients in the trial showed evidence of myocardial regeneration new heart tissue replacing former dead tissue killed by heart attack.

"The trial shows the feasibility of isolating and expanding autologous stem cells from virtually every patient," said Bolli, who is the Jewish Hospital Heart and Lung Institute Distinguished Chair in Cardiology and director of the Institute for Molecular Cardiology in the Department of Medicine at UofL. "The results suggest that this therapy has a potent, beneficial effect on cardiac function that warrants further study."

"In all patients, cells with high regenerative reserve were obtained and employed therapeutically," said Anversa, professor of Anaesthesia and Medicine at Brigham and Women's Hospital and Harvard Medical School. "Our efforts to carefully characterize the phenotype and growth properties of the cardiac stem cells may have contributed to these initial positive results."

The trial called SCIPIO for Stem Cell Infusion in Patients with Ischemic CardiOmyopathy was a randomized open-label trial of cardiac stem cells (CSCs) in patients who were diagnosed with heart failure following a myocardial infarction and had a LVEF of 40 percent or lower; the normal LVEF is 50 percent or higher.

The investigators harvested the CSCs, referred to as "c-kit positive" cells because they express the c-kit protein on their surface, from 33 patients during coronary artery bypass surgery. The stem cells were purified and processed in Anversa's lab in Boston so that they could multiply. Once an adequate number of stem cells was produced about one million for each patient Bolli's team in Louisville reintroduced them into the region of the patient's heart that had been scarred by the heart attack.

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2 years out, patients receiving stem cell therapy show sustained heart function improvement