Archive for May, 2020

The global Gene Therapy market study presents an all in all compilation of the historical, current and future outlook of the market as well as the factors responsible for such a growth. With SWOT analysis, the business study highlights the strengths, weaknesses, opportunities and threats of each Gene Therapy market player in a comprehensive way. Further, the Gene Therapy market report emphasizes the adoption pattern of the Gene Therapy across various industries.

The Gene Therapy market report examines the operating pattern of each player new product launches, partnerships, and acquisitions has been examined in detail.

The report on the Gene Therapy market provides a birds eye view of the current proceeding within the Gene Therapy market. Further, the report also takes into account the impact of the novel COVID-19 pandemic on the Gene Therapy market and offers a clear assessment of the projected market fluctuations during the forecast period.

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Regional and Country-level AnalysisThe report offers an exhaustive geographical analysis of the global Gene Therapy market, covering important regions, viz, North America, Europe, China, Japan, Southeast Asia, India and Central & South America. It also covers key countries (regions), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, UAE, etc.The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by each application segment in terms of revenue for the period 2015-2026.Competition AnalysisIn the competitive analysis section of the report, leading as well as prominent players of the global Gene Therapy market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.On the whole, the report proves to be an effective tool that players can use to gain a competitive edge over their competitors and ensure lasting success in the global Gene Therapy market. All of the findings, data, and information provided in the report are validated and revalidated with the help of trustworthy sources. The analysts who have authored the report took a unique and industry-best research and analysis approach for an in-depth study of the global Gene Therapy market.The following players are covered in this report:Bluebird BioSangamoSpark TherapeuticsDimension TherapeuticsAvalanche BioCelladonVical Inc.AdvantageneGene Therapy Breakdown Data by TypeEx vivoIn VivoGene Therapy Breakdown Data by ApplicationCancerMonogenicInfectious diseaseCardiovascular diseaseOther

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The Gene Therapy market report offers a plethora of insights which include:

The Gene Therapy market report answers important questions which include:

The Gene Therapy market report considers the following years to predict the market growth:

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Why Choose Gene Therapy Market Report?

Gene Therapy Market Reportfollows a multi- disciplinary approach to extract information about various industries. Our analysts perform thorough primary and secondary research to gather data associated with the market. With modern industrial and digitalization tools, we provide avant-garde business ideas to our clients. We address clients living in across parts of the world with our 24/7 service availability.

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Coronavirus threat to global Gene Therapy Market Size, Demand, Cost Structures, Latest trends, and Forecasts to 2025 - Cole of Duty

(MENAFN - iCrowdNewsWire) May 25, 2020

The hemophilia treatment market was valued at US$ 14,454.81 million in 2019 and is expected to grow at a CAGR of 15.9% from 2020 to 2027 to reach US$44,089.71 million by 2027.

Hemophilia is a condition where blood does not clot, and this condition is normally inherited. The condition is caused due to defects in a gene of the X chromosome, which is a clotting factor. Generally, the diseases are widely seen in males as the X chromosome is inherited from mother to baby boy. The disease is widely treated with replacement therapy and gene therapy. The other treatment which is used is medication. However, there are ways to reduce the risk of the condition, which include regular exercise and others. The condition can be prevented by taking preventive treatment by injection of clotting factor VIII for hemophilia A, or IX for hemophilia B.

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Some of the prominent players operating in hemophilia treatment market are, Bayer AG, Sanofi, F. Hoffmann-la Roche Ltd., Kedrion S.P.A., CSL Limited, Biotest AG, Pfizer Inc., Novo Nordisk A/S, Octapharma AG, and Baxter International Inc. The market players are focused towards acquisitions with industry players in order to sustain their position in the market. For instance, in February 2020, Novo Nordisk launched an antihemophilic product namely Esperoct. This product is likely to reduce the effect of hemophilia in adults and children with hemophilia A.

The hemophilia treatment market by product is segmented into plasma derived coagulation factor concentrates, recombinant coagulation factor concentrates, antifibrinolytic agents, desmopressin. In 2019, the plasma derived coagulation factor concentrates segment held a largest market share of the hemophilia treatment market. This segment is also expected to dominate the market in 2027. The large share of plasma derived coagulation factor concentrates based hemophilia treatment can be attributed to various advantages offered by these hemophilia treatment, deep market penetration and variety of products offered by multiple players to suit diverse medical application. On the other hand, the recombinant coagulation factor concentrates segment is anticipated to witness the highest growth rate during the forecast period. Certain factors such as effectiveness of the hemophilia treatment in lesser time and better efficient blood clotting are expected to drive the segment growth.

The plasma derived coagulation factor concentrates based hemophilia treatment captured the largest share in the globalhemophilia treatment market. A wide variety of hemophilia treatment is available as adjunctive measures to improve hemophilia if residual bleeding persists despite the correct application of conventional methods for hemorrhage control. Plasma-derived coagulation factor hemophilia treatment is considered to be active agents that participate in the coagulation cascade to form fibrin clots and are effective to make an intact coagulation system. Plasma is the liquid part of blood. It is pale yellow or straw-colored with proteins such as antibodies, albumin, and coagulation factors. There are several target factor drug products made from plasma proteins of human. The plasma is collected from group of people, and perform several processes to separate the plasma into its components.

In Italy, according to the data of the National Center for Biotechnology Information (NCBI) in 2017, the number of registered people with bleeding disorders increased from about 7000 in 2000 to around 8500 in 2011 and more than 11,000 in 2015. The trend is due to an upsurge in the number of patients who are recorded, mainly in those with vWD type 1, mild hemophilia, or other factor deficiencies.

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The report segments the global hemophilia treatment market as follows:

Global Hemophilia Treatment Market By Product

Global Hemophilia Treatment Market By Disease

Global Hemophilia Treatment Market By Treatment Type

Global Hemophilia Treatment Market By Therapy

Global Hemophilia Treatment Market By End User

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About Us: The Insight Partners is a one stop industry research provider of actionable intelligence. We help our clients in getting solutions to their research requirements through our syndicated and consulting research services. We are a specialist in Life Science, Technology, Healthcare, Manufacturing, Automotive and Defense, Food Beverages, Chemical etc.

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Hemophilia Treatment Market Analysis, By Key Players, Sale, Trends, Segmentation And Forecast By 2027 - MENAFN.COM

Fact.MR recently published a market study on Gene Therapy. The study provides detailed assessment on key market dynamics, including the drivers, trends, opportunities & restraints, and detailed information about the Gene Therapy market structure. The market study suggests that the global market size of Gene Therapy is projected to reach a CAGR of xx% over the stipulated timeframe2020-2026.

Key indicators of market growth, which include year-on-year (Y-o-Y) growth of the market, value chain, supply chain analysis, and compounded annual growth rate (CAGR) are explained in Fact.MRs study in a comprehensive manner. This information can help readers understand the quantitative growth prospects of the Gene Therapy market during the forecast period.

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The study is relevant for stakeholders in the Gene Therapy market, including Gene Therapy manufacturers, suppliers, distributors, and investors, and can help them in developing appropriate strategies to grow in the market. Stakeholders in the Gene Therapy market, investors, industry experts, researchers, and journalists, as well as business researchers can leverage the information and data presented in Fact.MRs study.

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The study also includes statistics as well as facts related to the macro as well as microeconomic factors that are impacting developments in the market. It also offers actionable insights based on the future trends in the Gene Therapy market. Furthermore, small businesses and new entrants in the Gene Therapy market too can make use of the information presented in this study, based on which, they can make appropriate business decisions in order to gain momentum in the market.

Important regions covered in the Gene Therapy market report include:

The Gene Therapy market report highlights players below:

The global Gene Therapy market report also covers consumption and production of products. The types are as follows:

On the basis of end-use, the report includes:

Key Questions Answered in Fact. MRs Gene Therapy Market Report

Gene Therapy Market: Research Methodology

In Fact.MRs study, a unique research methodology is utilized to conduct extensive research on the growth of the Gene Therapy market, and reach conclusions on the future growth parameters of the market. This research methodology is a combination of primary and secondary research, which helps analysts ensure the accuracy and reliability of the conclusions.

Secondary resources referred to by analysts during the production of the Gene Therapy market study include statistics from governmental organizations, trade journals, white papers, and internal and external proprietary databases. Analysts have interviewed senior managers, product portfolio managers, CEOs, VPs, marketing/product managers, and market intelligence managers, who contributed to the development of this report as a primary resource.

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Comprehensive information acquired from primary resources and secondary resources acts as a validation from companies in the soy protein concentrate market, and makes Fact. MRs projection on the growth prospects of the Gene Therapy market more accurate and reliable.

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COVID-19 Industry Impact: Gene Therapy Analyzed for Forecast Year - The Cloud Tribune

Global Neurologic Disorders Therapeutics Market: Overview

In todays age, neurologic disorders are becoming increasingly common, especially neurodegenerative diseases. According to various studies, the growth of these neurological disorders is spreading rapidly across Europe and other parts of the world. In addition to this, the treatment for such disorders is also very challenging because of the presence of the strictly regulated blood-brain barrier. It is also challenging due to the unique ability to cover the brain from the new therapeutics. Traditional therapeutics, although effective, are still below the optimum level required for efficient treatment. Hence, there is need for finding newer and more effective therapeutics. This has thus given rise to the neurologic disorders therapeutics market.

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Global Neurologic Disorders Therapeutics Market: Notable Developments

Some of the notable developments in the global neurologic disorders therapeutics market are listed below:

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Names of other notable players in the global neurologic disorders therapeuticsmarket are listed below:

Global Neurologic Disorders Therapeutics Market: Drivers and Restraints

There are several factors that are influencing the growth of the global neurologic disorders therapeutics market. One of the key driving factors is the increasing advances in the diagnosis of the different neurodegenerative indications. This has helped in increasing the demand for new therapeutics to effectively treat such neurodegenerative disorders. The early determination such disorders is difficult due to its complex nature of such disorders, lack of efficient diagnostics, and its fast progression. This has naturally helped in driving the activities of research and development for more effective treatment. Governments across the globe are also helping research institutes by allotting more funds for the development of new neurologic disorder therapeutics.

Global Neurologic Disorders Therapeutics Market: Geographical Outlook

The global neurologic disorders therapeutics market is primarily divided into five key regions viz. North America, Latin America, the Middle East and Africa, Europe, and Asia Pacific. Of these, the global neurologic disorders therapeutics market is primarily dominated by North America region. This is because of the high aging population in the region, advancements in technology, and highly developed healthcare infrastructure.

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Neurologic Disorders Therapeutics Market Scope and Opportunities Analysis 2018 2028 - Cole of Duty

The Expression Vectors market report on the world market encompasses an evaluation of distinct parameters that uplift the growth of the global industry. In addition to this, all the industry manufacturers can utilize the market report to create themselves for facing tough market challenges and further competition in the universal market. Insightful information on notable strategies adopted by vital firms along with their key impact on the industry growth has been administrated in this market document. This Expression Vectors market research report gives explanation of market restraints, key drivers, and industry trends that transform the international market either in a positive or negative manner.

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Market AnalysisBesides target market information, DBMR also provides information about your competitor, your customers, products etc. A few techniques we use are: Customer analysis Competitor analysis Risk analysis Product research Advertising research E-mail survey and many more

Globalexpression vectorsmarketis set to witness a substantial CAGR of 6.3% in the forecast period of 2019-2026. The report contains data of the base year 2018 and historic year 2017. The rise in the market value can be attributed to increasing prevalence of infectious diseases, genetic disorders and other lifestyle associated diseases.

Some of the major players operating in globalexpression vectors marketareDNA TwoPointO Inc., Thermo Fisher Scientific, Inc., Promega Corporation, Agilent Technologies, Inc., Bio-Rad Laboratories Inc., QIAGEN, Merck KGaA, TAKARA HOLDINGS Inc., New England Biolabs, GenScript, Quest Diagnostics ,Synbio Technologies, Addgene,Inc., BD, OriGene Technologies, Inc., InvivoGen, GeneCopoeia, Inc., ATCC, tebu-bio, System Biosciences, LLC., Sanofi, transOMIC, Genlantis Inc., Macrogen, Inc. and Gene Bridges GmbH among others.

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Market Definition: Global Expression VectorsMarket

Expression vector is a vector that is used in genetic engineering which enables a particular gene to be cloned and expressed in a host cell.These vectors are also used in genetics, molecular biology and computer sciences. A specific gene is initiated to enter into a target cell via expression vector. Protein expression is a technique in which proteins are modulated, transformed and synthesized in living organisms or cells.

In2019, the statistics obtained from the American Cancer Societys publication and the National Cancer Institutes Surveillance Epidemiology, is believed that 268,600 women and 2,670 men in the United States will be diagnosed with breast cancer. It is estimated that from breast cancer 42,260 deaths will occur this year.Wide variety of cancers can be treated by multiple gene therapy strategies, including suicide gene therapy and therapeutic gene vaccines.

Segmentation:Global Expression VectorsMarket

Expression Vectors Market : By Host Type

Expression Vectors Market : By Application

Expression Vectors Market : By End User

Expression Vectors Market : ByGeography

Key Developments in the Expression Vectors Market :

Expression Vectors Market : Competitive Analysis:

Globalexpression vectorsmarketis highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares ofexpression vectorsfor Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Primary Respondents

Demand Side: Doctors, Surgeons, Medical Consultants, Nurses, Hospital Buyers, Group Purchasing Organizations, Associations, Insurers, Medical Payers, Healthcare Authorities, Universities, Technical Writers, Scientists, Promoters, and Investors among others.

Supply Side: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence and Regulatory Affairs Managers among others.

Opportunities in the Expression Vectors Market Report :

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Covid-19 Impact On Global Expression Vectors Market 2020 : Industry Trends, Size, Growth, Swot Analysis By Top Key Players And Forecast Report To 2026...

The market research report published by QYResearch is a brilliant, in-dept, complete, and much-needed resource for companies, stakeholders, and investors interested in the global Global Advanced Therapy Medicinal Products market. It informs readers about key trends and opportunities in the global Global Advanced Therapy Medicinal Products market along with critical market dynamics expected to impact the global market growth. It offers a range of market analysis studies, including production and consumption, sales, industry value chain, competitive landscape, regional growth, and price. On the whole, it comes out as an intelligent resource that companies can use to gain a competitive advantage in the global Global Advanced Therapy Medicinal Products market.

Key companies operating in the global Global Advanced Therapy Medicinal Products market include , Spark Therapeutics, Bluebird Bio, Novartis, UniQure, Celgene Corporation, Gilead Lifesciences, Kolon TissueGene, JCR Pharmaceuticals, MEDIPOST, Vericel Corporation, PHARMICELL

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Segmental Analysis

Both developed and emerging regions are deeply studied by the authors of the report. The regional analysis section of the report offers a comprehensive analysis of the global Global Advanced Therapy Medicinal Products market on the basis of region. Each region is exhaustively researched about so that players can use the analysis to tap into unexplored markets and plan powerful strategies to gain a foothold in lucrative markets.

Global Global Advanced Therapy Medicinal Products Market Segment By Type:

, Cell Therapy, CAR-T Therapy, Gene Therapy, Tissue Engineered Product

Global Global Advanced Therapy Medicinal Products Market Segment By Application:

Advanced therapy medicinal products(ATMPs) are medicines for human use that are based on genes, tissues or cells. They offer groundbreaking new opportunities for the treatment of disease and injury. Market Analysis and Insights: Global Advanced Therapy Medicinal Products Market Prior to COVID-19, the market for Advanced Therapy Medicinal Products was anticipated to grow from US$ XX million in 2020 to US$ XX million by 2026; it is expected to grow at a CAGR of XX% during 20212026, whereas post-COVID-19 scenario, the market for Advanced Therapy Medicinal Products is projected to grow from US$ XX million in 2020 (a change by ~XX% compared to market estimated for 2020 before the outbreak of COVID-19) to US$ XX billion by 2026; it is expected to grow at a CAGR of XX% during 20212026. The solicitation of proposals by the governments and publicprivate companies across the world to mitigate the impact of the COVID-19 pandemic is the key factor propelling the growth of the Advanced Therapy Medicinal Products market. Global Advanced Therapy Medicinal Products Scope and Segment The global Advanced Therapy Medicinal Products market is segmented by company, region (country), by Type, and by Application. Players, stakeholders, and other participants in the global Advanced Therapy Medicinal Products market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on revenue and forecast by region (country), by Type, and by Application for the period 2015-2026. Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost 200 countries around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Advanced Therapy Medicinal Products market in 2020. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future. The major regions covered in the report are North America, Europe, China, Rest of Asia Pacific, Central & South America, Middle East & Africa, etc. It includes revenue analysis of each region for the year 2015 to 2026. This report also analyzes the impact of Coronavirus COVID-19 on the Advanced Therapy Medicinal Products industry. By the type, the market is primarily split into Cell Therapy CAR-T Therapy Gene Therapy Tissue Engineered Product By the application, this report covers the following segments Hospital Clinic

Competitive Landscape

Competitor analysis is one of the best sections of the report that compares the progress of leading players based on crucial parameters, including market share, new developments, global reach, local competition, price, and production. From the nature of competition to future changes in the vendor landscape, the report provides in-depth analysis of the competition in the global Global Advanced Therapy Medicinal Products market.

Key companies operating in the global Global Advanced Therapy Medicinal Products market include , Spark Therapeutics, Bluebird Bio, Novartis, UniQure, Celgene Corporation, Gilead Lifesciences, Kolon TissueGene, JCR Pharmaceuticals, MEDIPOST, Vericel Corporation, PHARMICELL

Key questions answered in the report:

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TOC

1 Market Overview of Advanced Therapy Medicinal Products1.1 Advanced Therapy Medicinal Products Market Overview1.1.1 Advanced Therapy Medicinal Products Product Scope1.1.2 Market Status and Outlook1.2 Global Advanced Therapy Medicinal Products Market Size Overview by Region 2015 VS 2020 VS 20261.3 Global Advanced Therapy Medicinal Products Market Size by Region (2015-2026)1.4 Global Advanced Therapy Medicinal Products Historic Market Size by Region (2015-2020)1.5 Global Advanced Therapy Medicinal Products Market Size Forecast by Region (2021-2026)1.6 Covid-19 Impact on Key Regions, Advanced Therapy Medicinal Products Market Size YoY Growth (2015-2026)1.6.1 North America Advanced Therapy Medicinal Products Market Size YoY Growth (2015-2026)1.6.2 Europe Advanced Therapy Medicinal Products Market Size YoY Growth (2015-2026)1.6.3 China Advanced Therapy Medicinal Products Market Size YoY Growth (2015-2026)1.6.4 Rest of Asia Pacific Advanced Therapy Medicinal Products Market Size YoY Growth (2015-2026)1.6.5 Latin America Advanced Therapy Medicinal Products Market Size YoY Growth (2015-2026)1.6.6 Middle East & Africa Advanced Therapy Medicinal Products Market Size YoY Growth (2015-2026)1.7 Coronavirus Disease 2019 (Covid-19) Impact Will Have a Severe Impact on Global Growth1.7.1 Covid-19 Impact: Global GDP Growth, 2019, 2020 and 2021 Projections1.7.2 Covid-19 Impact: Commodity Prices Indices1.7.3 Covid-19 Impact: Global Major Government Policy 2 Covid-19 Impact on Advanced Therapy Medicinal Products Market Overview by Type2.1 Global Advanced Therapy Medicinal Products Market Size by Type: 2015 VS 2020 VS 20262.2 Global Advanced Therapy Medicinal Products Historic Market Size by Type (2015-2020)2.3 Global Advanced Therapy Medicinal Products Forecasted Market Size by Type (2021-2026)2.4 Cell Therapy2.5 CAR-T Therapy2.6 Gene Therapy2.7 Tissue Engineered Product 3 Covid-19 Impact on Advanced Therapy Medicinal Products Market Overview by Application3.1 Global Advanced Therapy Medicinal Products Market Size by Application: 2015 VS 2020 VS 20263.2 Global Advanced Therapy Medicinal Products Historic Market Size by Application (2015-2020)3.3 Global Advanced Therapy Medicinal Products Forecasted Market Size by Application (2021-2026)3.4 Hospital3.5 Clinic 4 Covid-19 Impact on Global Advanced Therapy Medicinal Products Competition Analysis by Players4.1 Global Advanced Therapy Medicinal Products Market Size (Million US$) by Players (2015-2020)4.2 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Advanced Therapy Medicinal Products as of 2019)4.3 Date of Key Manufacturers Enter into Advanced Therapy Medicinal Products Market4.4 Global Top Players Advanced Therapy Medicinal Products Headquarters and Area Served4.5 Key Players Advanced Therapy Medicinal Products Product Solution and Service4.6 Competitive Status4.6.1 Advanced Therapy Medicinal Products Market Concentration Rate4.6.2 Mergers & Acquisitions, Expansion Plans 5 Company (Top Players) Profiles and Key Data5.1 Spark Therapeutics5.1.1 Spark Therapeutics Profile5.1.2 Spark Therapeutics Main Business and Companys Total Revenue5.1.3 Spark Therapeutics Products, Services and Solutions5.1.4 Spark Therapeutics Revenue (US$ Million) (2015-2020)5.1.5 Spark Therapeutics Recent Development and Reaction to Covid-195.2 Bluebird Bio5.2.1 Bluebird Bio Profile5.2.2 Bluebird Bio Main Business and Companys Total Revenue5.2.3 Bluebird Bio Products, Services and Solutions5.2.4 Bluebird Bio Revenue (US$ Million) (2015-2020)5.2.5 Bluebird Bio Recent Development and Reaction to Covid-195.3 Novartis5.5.1 Novartis Profile5.3.2 Novartis Main Business and Companys Total Revenue5.3.3 Novartis Products, Services and Solutions5.3.4 Novartis Revenue (US$ Million) (2015-2020)5.3.5 UniQure Recent Development and Reaction to Covid-195.4 UniQure5.4.1 UniQure Profile5.4.2 UniQure Main Business and Companys Total Revenue5.4.3 UniQure Products, Services and Solutions5.4.4 UniQure Revenue (US$ Million) (2015-2020)5.4.5 UniQure Recent Development and Reaction to Covid-195.5 Celgene Corporation5.5.1 Celgene Corporation Profile5.5.2 Celgene Corporation Main Business and Companys Total Revenue5.5.3 Celgene Corporation Products, Services and Solutions5.5.4 Celgene Corporation Revenue (US$ Million) (2015-2020)5.5.5 Celgene Corporation Recent Development and Reaction to Covid-195.6 Gilead Lifesciences5.6.1 Gilead Lifesciences Profile5.6.2 Gilead Lifesciences Main Business and Companys Total Revenue5.6.3 Gilead Lifesciences Products, Services and Solutions5.6.4 Gilead Lifesciences Revenue (US$ Million) (2015-2020)5.6.5 Gilead Lifesciences Recent Development and Reaction to Covid-195.7 Kolon TissueGene5.7.1 Kolon TissueGene Profile5.7.2 Kolon TissueGene Main Business and Companys Total Revenue5.7.3 Kolon TissueGene Products, Services and Solutions5.7.4 Kolon TissueGene Revenue (US$ Million) (2015-2020)5.7.5 Kolon TissueGene Recent Development and Reaction to Covid-195.8 JCR Pharmaceuticals5.8.1 JCR Pharmaceuticals Profile5.8.2 JCR Pharmaceuticals Main Business and Companys Total Revenue5.8.3 JCR Pharmaceuticals Products, Services and Solutions5.8.4 JCR Pharmaceuticals Revenue (US$ Million) (2015-2020)5.8.5 JCR Pharmaceuticals Recent Development and Reaction to Covid-195.9 MEDIPOST5.9.1 MEDIPOST Profile5.9.2 MEDIPOST Main Business and Companys Total Revenue5.9.3 MEDIPOST Products, Services and Solutions5.9.4 MEDIPOST Revenue (US$ Million) (2015-2020)5.9.5 MEDIPOST Recent Development and Reaction to Covid-195.10 Vericel Corporation5.10.1 Vericel Corporation Profile5.10.2 Vericel Corporation Main Business and Companys Total Revenue5.10.3 Vericel Corporation Products, Services and Solutions5.10.4 Vericel Corporation Revenue (US$ Million) (2015-2020)5.10.5 Vericel Corporation Recent Development and Reaction to Covid-195.11 PHARMICELL5.11.1 PHARMICELL Profile5.11.2 PHARMICELL Main Business and Companys Total Revenue5.11.3 PHARMICELL Products, Services and Solutions5.11.4 PHARMICELL Revenue (US$ Million) (2015-2020)5.11.5 PHARMICELL Recent Development and Reaction to Covid-19 6 North America Advanced Therapy Medicinal Products by Players and by Application6.1 North America Advanced Therapy Medicinal Products Market Size and Market Share by Players (2015-2020)6.2 North America Advanced Therapy Medicinal Products Market Size by Application (2015-2020) 7 Europe Advanced Therapy Medicinal Products by Players and by Application7.1 Europe Advanced Therapy Medicinal Products Market Size and Market Share by Players (2015-2020)7.2 Europe Advanced Therapy Medicinal Products Market Size by Application (2015-2020) 8 China Advanced Therapy Medicinal Products by Players and by Application8.1 China Advanced Therapy Medicinal Products Market Size and Market Share by Players (2015-2020)8.2 China Advanced Therapy Medicinal Products Market Size by Application (2015-2020) 9 Rest of Asia Pacific Advanced Therapy Medicinal Products by Players and by Application9.1 Rest of Asia Pacific Advanced Therapy Medicinal Products Market Size and Market Share by Players (2015-2020)9.2 Rest of Asia Pacific Advanced Therapy Medicinal Products Market Size by Application (2015-2020) 10 Latin America Advanced Therapy Medicinal Products by Players and by Application10.1 Latin America Advanced Therapy Medicinal Products Market Size and Market Share by Players (2015-2020)10.2 Latin America Advanced Therapy Medicinal Products Market Size by Application (2015-2020) 11 Middle East & Africa Advanced Therapy Medicinal Products by Players and by Application11.1 Middle East & Africa Advanced Therapy Medicinal Products Market Size and Market Share by Players (2015-2020)11.2 Middle East & Africa Advanced Therapy Medicinal Products Market Size by Application (2015-2020) 12 Advanced Therapy Medicinal Products Market Dynamics12.1 Covid-19 Impact: Industry Trends12.2 Covid-19 Impact: Market Drivers12.3 Covid-19 Impact: Market Challenges12.4 Porters Five Forces Analysis 13 Research Finding /Conclusion 14 Methodology and Data Source 14.1 Methodology/Research Approach14.1.1 Research Programs/Design14.1.2 Market Size Estimation14.1.3 Market Breakdown and Data Triangulation14.2 Data Source14.2.1 Secondary Sources14.2.2 Primary Sources14.3 Disclaimer14.4 Author List

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Global Advanced Therapy Medicinal Products Market Size, Analytical Overview, Growth Factors, Demand, Trends and Forecast to 2026 - Cole of Duty

DURANGO, Colo. After nearly a two-year wait, Colorado Parks and Wildlife hatchery staff and biologists in Durango have spawned a new lineage of Colorado River cutthroat trout that were rescued from a remote stream during the 416 Fire in 2018.

This marks a major milestone forCPWs on-going species conservation work in Colorado, and the result of decades of work by dedicated biologists, researchers and field staff.

Fertilized eggs of the San Juan cutthroats will hatch by mid-summer; some of the fingerlings will be placed in back-country streams in the southwest area of the state and others will be held at the Durango hatchery to start a sustainable brood stock. Now, the hatchery staff and biologists will continue the long-term effort to restore these native trout to their home waters.

Im thrilled that weve gotten a spawn from these fish, its been a long process and weve got a lot more work to do, said Jim White, aquatic biologist forCPWin Durango.

The story of these fish that hold a unique genetic marker goes back nearly 150 years and includes some serious biological detective work. Since the 1970s,CPWaquatic biologists have searched back-country streams looking for isolated populations of cutthroats Colorados native trout. In southwest Colorado in the 1980s and 1990s, biologists found cutthroat trout that were suspected to have unique characteristics in eight small streams. Back then, however, technology to analyze genetics fully was still being developed. The biologists kept their eyes on the fish and made sure non-native trout were not stocked nearby.

In 2012, researchers from the University of Colorado went to the Smithsonian National Museum of Natural History looking for preserved specimens of cutthroat trout that had been collected in Colorado. Two of the specimens they found were taken from the San Juan River near Pagosa Springs in 1874.

An analysis showed that the fish had genetic fingerprints specific to the San Juan River Basin.CPWresearchers then began a similar analysis of the cutthroats theyd found in southwest Colorado. By this time, genetic-analysis technology had advanced and in early 2018 scientists confirmed that the marker in the museum specimens matched the cutthroat trout recently found in the wild.

Biologists and hatchery staff then made a plan to start propagating the fish. The 416 Fire helped push the project along.

When the fire started north of Durango, biologists worried that ash and sediment run-off could kill the cutthroats in the remote streams. SoCPWworked with the San Juan National Forest to go into the area to capture the wild trout and bring them to a special isolation hatchery in Durango. Only 54 cutthroat were recovered from the fire area.

White and Durango Hatchery Manager Toby Mourning have been concerned because the fish did not produce any spawn last year and some of the fish died. But the turnaround this year is a major milestone for the restoration effort.

Were not getting a lot of eggs, but enough to provide some for a limited amount of stocking and some to start a captive population that will be sustainable, Mourning said.

In order to protect the fish,CPWis not providing details on stream locations. Biologists hope, however, that in a few years anglers will be able to find this unique cutthroat trout in the wild.

White explained that the work on this native is a significant conservation effort. In 2018, after the genetics of the fish were confirmed, he said: We always ask ourselves, What if we could go back to the days before mining, pioneer settlement and wide-spread non-native fish stocking to see what we had here? Careful work over the years by biologists, finding those old specimens in the museum and the genetic testing gave us the chance, essentially, to go back in time. Now we have the opportunity to bring this native trout back to southwest Colorado.

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Durango hatchery takes first spawn from rare cutthroat trout rescued in 416 Fire - Fort Morgan Times

The market research report published by QYResearch is a brilliant, in-dept, complete, and much-needed resource for companies, stakeholders, and investors interested in the global Preimplantation Genetic Testing market. It informs readers about key trends and opportunities in the global Preimplantation Genetic Testing market along with critical market dynamics expected to impact the global market growth. It offers a range of market analysis studies, including production and consumption, sales, industry value chain, competitive landscape, regional growth, and price. On the whole, it comes out as an intelligent resource that companies can use to gain a competitive advantage in the global Preimplantation Genetic Testing market.

Key companies operating in the global Preimplantation Genetic Testing market include Illumina, Thermo Fisher, Agilent Technologies, Perkinelmer, Coopersurgical, Abbott Laboratories, Natera, Rubicon Genomics, Oxford Gene Technology, Yikon Genomics, Scigene, Beijing Genomics Institute, Good Start Genetics, Invicta Genetics, Combimatrix, Genea Limited, Progenesis, etc.

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Segmental Analysis

Both developed and emerging regions are deeply studied by the authors of the report. The regional analysis section of the report offers a comprehensive analysis of the global Preimplantation Genetic Testing market on the basis of region. Each region is exhaustively researched about so that players can use the analysis to tap into unexplored markets and plan powerful strategies to gain a foothold in lucrative markets.

Global Preimplantation Genetic Testing Market Segment By Type:

, Preimplantation Genetic Screening, Preimplantation Genetic Diagnosis

Global Preimplantation Genetic Testing Market Segment By Application:

Maternity Centers & Fertility Clinics Hospitals, Diagnostic Labs, and Service Providers Research Laboratories & Academic Institutes

Competitive Landscape

Competitor analysis is one of the best sections of the report that compares the progress of leading players based on crucial parameters, including market share, new developments, global reach, local competition, price, and production. From the nature of competition to future changes in the vendor landscape, the report provides in-depth analysis of the competition in the global Preimplantation Genetic Testing market.

Key companies operating in the global Preimplantation Genetic Testing market include Illumina, Thermo Fisher, Agilent Technologies, Perkinelmer, Coopersurgical, Abbott Laboratories, Natera, Rubicon Genomics, Oxford Gene Technology, Yikon Genomics, Scigene, Beijing Genomics Institute, Good Start Genetics, Invicta Genetics, Combimatrix, Genea Limited, Progenesis, etc.

Key questions answered in the report:

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TOC

1.1 Research Scope1.2 Market Segmentation1.3 Research Objectives1.4 Research Methodology1.4.1 Research Process1.4.2 Data Triangulation1.4.3 Research Approach1.4.4 Base Year1.5 Coronavirus Disease 2019 (Covid-19) Impact Will Have a Severe Impact on Global Growth1.5.1 Covid-19 Impact: Global GDP Growth, 2019, 2020 and 2021 Projections1.5.2 Covid-19 Impact: Commodity Prices Indices1.5.3 Covid-19 Impact: Global Major Government Policy1.6 The Covid-19 Impact on Preimplantation Genetic Testing Industry1.7 COVID-19 Impact: Preimplantation Genetic Testing Market Trends 2 Global Preimplantation Genetic Testing Quarterly Market Size Analysis2.1 Preimplantation Genetic Testing Business Impact Assessment COVID-192.1.1 Global Preimplantation Genetic Testing Market Size, Pre-COVID-19 and Post- COVID-19 Comparison, 2015-20262.2 Global Preimplantation Genetic Testing Quarterly Market Size 2020-20212.3 COVID-19-Driven Market Dynamics and Factor Analysis2.3.1 Drivers2.3.2 Restraints2.3.3 Opportunities2.3.4 Challenges 3 Quarterly Competitive Assessment, 20203.1 By Players, Global Preimplantation Genetic Testing Quarterly Market Size, 2019 VS 20203.2 By Players, Preimplantation Genetic Testing Headquarters and Area Served3.3 Date of Key Players Enter into Preimplantation Genetic Testing Market3.4 Key Players Preimplantation Genetic Testing Product Offered3.5 Mergers & Acquisitions, Expansion Plans 4 Impact of Covid-19 on Preimplantation Genetic Testing Segments, By Type4.1 Introduction1.4.1 Preimplantation Genetic Screening1.4.2 Preimplantation Genetic Diagnosis4.2 By Type, Global Preimplantation Genetic Testing Market Size, 2019-2021 5 Impact of Covid-19 on Preimplantation Genetic Testing Segments, By Application5.1 Overview5.5.1 Maternity Centers & Fertility Clinics5.5.2 Hospitals, Diagnostic Labs, and Service Providers5.5.3 Research Laboratories & Academic Institutes5.2 By Application, Global Preimplantation Genetic Testing Market Size, 2019-20215.2.1 By Application, Global Preimplantation Genetic Testing Market Size by Application, 2019-2021 6 Geographic Analysis6.1 Introduction6.2 North America6.2.1 Macroeconomic Indicators of US6.2.2 US6.2.3 Canada6.3 Europe6.3.1 Macroeconomic Indicators of Europe6.3.2 Germany6.3.3 France6.3.4 UK6.3.5 Italy6.4 Asia-Pacific6.4.1 Macroeconomic Indicators of Asia-Pacific6.4.2 China6.4.3 Japan6.4.4 South Korea6.4.5 India6.4.6 ASEAN6.5 Rest of World6.5.1 Latin America6.5.2 Middle East and Africa 7 Company Profiles7.1 Illumina7.1.1 Illumina Business Overview7.1.2 Illumina Preimplantation Genetic Testing Quarterly Revenue, 20207.1.3 Illumina Preimplantation Genetic Testing Product Introduction7.1.4 Illumina Response to COVID-19 and Related Developments7.2 Thermo Fisher7.2.1 Thermo Fisher Business Overview7.2.2 Thermo Fisher Preimplantation Genetic Testing Quarterly Revenue, 20207.2.3 Thermo Fisher Preimplantation Genetic Testing Product Introduction7.2.4 Thermo Fisher Response to COVID-19 and Related Developments7.3 Agilent Technologies7.3.1 Agilent Technologies Business Overview7.3.2 Agilent Technologies Preimplantation Genetic Testing Quarterly Revenue, 20207.3.3 Agilent Technologies Preimplantation Genetic Testing Product Introduction7.3.4 Agilent Technologies Response to COVID-19 and Related Developments7.4 Perkinelmer7.4.1 Perkinelmer Business Overview7.4.2 Perkinelmer Preimplantation Genetic Testing Quarterly Revenue, 20207.4.3 Perkinelmer Preimplantation Genetic Testing Product Introduction7.4.4 Perkinelmer Response to COVID-19 and Related Developments7.5 Coopersurgical7.5.1 Coopersurgical Business Overview7.5.2 Coopersurgical Preimplantation Genetic Testing Quarterly Revenue, 20207.5.3 Coopersurgical Preimplantation Genetic Testing Product Introduction7.5.4 Coopersurgical Response to COVID-19 and Related Developments7.6 Abbott Laboratories7.6.1 Abbott Laboratories Business Overview7.6.2 Abbott Laboratories Preimplantation Genetic Testing Quarterly Revenue, 20207.6.3 Abbott Laboratories Preimplantation Genetic Testing Product Introduction7.6.4 Abbott Laboratories Response to COVID-19 and Related Developments7.7 Natera7.7.1 Natera Business Overview7.7.2 Natera Preimplantation Genetic Testing Quarterly Revenue, 20207.7.3 Natera Preimplantation Genetic Testing Product Introduction7.7.4 Natera Response to COVID-19 and Related Developments7.8 Rubicon Genomics7.8.1 Rubicon Genomics Business Overview7.8.2 Rubicon Genomics Preimplantation Genetic Testing Quarterly Revenue, 20207.8.3 Rubicon Genomics Preimplantation Genetic Testing Product Introduction7.8.4 Rubicon Genomics Response to COVID-19 and Related Developments7.9 Oxford Gene Technology7.9.1 Oxford Gene Technology Business Overview7.9.2 Oxford Gene Technology Preimplantation Genetic Testing Quarterly Revenue, 20207.9.3 Oxford Gene Technology Preimplantation Genetic Testing Product Introduction7.9.4 Oxford Gene Technology Response to COVID-19 and Related Developments7.10 Yikon Genomics7.10.1 Yikon Genomics Business Overview7.10.2 Yikon Genomics Preimplantation Genetic Testing Quarterly Revenue, 20207.10.3 Yikon Genomics Preimplantation Genetic Testing Product Introduction7.10.4 Yikon Genomics Response to COVID-19 and Related Developments7.11 Scigene7.11.1 Scigene Business Overview7.11.2 Scigene Preimplantation Genetic Testing Quarterly Revenue, 20207.11.3 Scigene Preimplantation Genetic Testing Product Introduction7.11.4 Scigene Response to COVID-19 and Related Developments7.12 Beijing Genomics Institute7.12.1 Beijing Genomics Institute Business Overview7.12.2 Beijing Genomics Institute Preimplantation Genetic Testing Quarterly Revenue, 20207.12.3 Beijing Genomics Institute Preimplantation Genetic Testing Product Introduction7.12.4 Beijing Genomics Institute Response to COVID-19 and Related Developments7.13 Good Start Genetics7.13.1 Good Start Genetics Business Overview7.13.2 Good Start Genetics Preimplantation Genetic Testing Quarterly Revenue, 20207.13.3 Good Start Genetics Preimplantation Genetic Testing Product Introduction7.13.4 Good Start Genetics Response to COVID-19 and Related Developments7.14 Invicta Genetics7.14.1 Invicta Genetics Business Overview7.14.2 Invicta Genetics Preimplantation Genetic Testing Quarterly Revenue, 20207.14.3 Invicta Genetics Preimplantation Genetic Testing Product Introduction7.14.4 Invicta Genetics Response to COVID-19 and Related Developments7.15 Combimatrix7.15.1 Combimatrix Business Overview7.15.2 Combimatrix Preimplantation Genetic Testing Quarterly Revenue, 20207.15.3 Combimatrix Preimplantation Genetic Testing Product Introduction7.15.4 Combimatrix Response to COVID-19 and Related Developments7.16 Genea Limited7.16.1 Genea Limited Business Overview7.16.2 Genea Limited Preimplantation Genetic Testing Quarterly Revenue, 20207.16.3 Genea Limited Preimplantation Genetic Testing Product Introduction7.16.4 Genea Limited Response to COVID-19 and Related Developments7.17 Progenesis7.17.1 Progenesis Business Overview7.17.2 Progenesis Preimplantation Genetic Testing Quarterly Revenue, 20207.17.3 Progenesis Preimplantation Genetic Testing Product Introduction7.17.4 Progenesis Response to COVID-19 and Related Developments 8 Key Findings 9 Appendix9.1 About US9.2 Disclaimer

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Preimplantation Genetic Testing Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 - Bulletin Line

My wife and I can both roll our tongues but our son can't. I'm worried about his paternity (Photo: Shutterstock)

I am a 36-year-old woman and have no children, but I am planning on having some in a few years. Is it true that with advancing age I increase my chances of getting a child with Downs syndrome or cerebral palsy?

ALSO READ: Ask the doctor: Is penile enlargement surgery considered plastic surgery? Does it work?

Yes, these conditions have been associated with problematic pregnancies and abnormal foetal development. After age 35, older eggs tend to have abnormal cell division where the chromosomes may fail to separate in the correct way, leading to an excess number of expected chromosomes.

For example, in Downs syndrome, the foetus has an extra chromosome resulting in what is referred to as trisomy. Cerebral palsy is associated with complications of advanced parental age, especially the mothers. These may include miscarriages, multiple births, high blood pressure, gestational diabetes, and genetic mutations that impact brain development. Studies have also suggested that an older couple is more likely to use infertility procedures that can increase the risk of multiples and other risk factors.

I discovered that my fiances sister has albinism. How likely is it that any of our future children develops the condition?

There is a 50 percent chance your fiance is a carrier for the albinism gene. If this holds true, then there is a 25 percent chance that your future children may develop this condition.

My wife can roll her tongue (the rolling tongue gene). So can I. But our son, now 4, cant. I am worried about my childs paternity but dont want to stir the marriage yet. Do you think I should be worried or is there a genetic explanation?

There should be no cause to worry. More recent studies disputed the misleading assumption that leads to the conclusion that is worrying you. There was a study on identical twins who differed in their tongue-rolling trait, suggesting that the trait was not entirely under genomic influence as identical twins have the same genetic makeup.

I hope to get a child through a sperm bank. Do you think my request for physical characteristics of the sperm donor will help towards getting desirable traits in my future child?

ALSO READ: Why its better to have children before your 40s

Yes, most physical characteristics are easily inherited from parents to their offspring. However, this could be a mixture of traits from both the donor and the recipient.

How far is the world from genetically engineering desirable traits into people and consequently having designer babies?

It is already happening on a smaller scale for certain traits, for example women or men going to sperm banks look for super straights in their donors for IVF procedures.

The world is also moving towards precision medicine, or what is commonly known as personalised medicine where everyone has their medicine tailor-made to suit their genes and condition based on their genetic fingerprint.

With technologies such as CRISPR/Cas9 gene editing, the future of designer babies is possible although ethical considerations in human cloning restrict such practices and may fail to promote advancements in these technologies.

Can I influence my childrens personalities or are they predetermined before birth?

To some extent yes, but personality is influenced by various factors. One component may come from the genes and the other from environmental interactions. For example, exposure to different life circumstances greatly influences ones personality.

ALSO READ: Ask the doctor: How do I bring back the white colour of my child's discoloured teeth?

My four-year-old twins are very different. My son has a real mean streak. Hes always been like that. His sister is kind. I have been responsible for their upbringing so far. Are character traits in the genes?

The difference could be in their genetic makeup. As we know, we inherit half of our genes from each parent and different personality traits could arise from this. In addition, the contrast in their personality could emanate from their daily interactions with the external world, such as from observations.

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You also have not told us if you treat the children differently whereby in most cases girls are treated kindly with lots of pampering, which is thus reflected in their behaviour. Boys who are often groomed to harden up to face the real world like men and turn out as brave warriors.

As a geneticist, do you think psychopaths are born or made?

I think it is a mixed bag of fortunes here. Psychopaths could result from nature and nurture. Several studies have pointed to the existence of genetic abnormalities in psychopaths, whereas other cases have risen purely from their upbringing. For example, we have had cases of sociopathic behaviour arising after traumatic experiences and drug addiction.Couples can undergo genetic testing to determine if they have any conditions their children can inherit (Photo: Shutterstock)

I have read a bit about genetic testing for couples, and I am considering it before we start a family. My question is, if they find something worrying (my sister died of sickle cell anaemia) can it be prevented because we know beforehand?

It may not be prevented in its entirety, but may help in early management of the outcome. It may also help in decision making whether to proceed and have children in the full knowledge that they may develop an inherited condition from parents. For your case, you could be a carrier for sickle cell disease and this prepares you to seek genetic therapy such as stem cell transplants to correct the abnormal red (sickle) cells.

I did the BRCA gene test and I have the mutated gene. What are the chances I could get ovarian or breast cancer?

A mutated BRCA gene is only an indicator of higher risk of developing either ovarian or breast cancer. It does not mean that you already have the cancer. It helps you prepare to seek and make a plan for testing and monitoring of signs of the development of these cancers so that preventative or management measures can be instituted. This may help in following a lifestyle that can reduce the chances of accelerating the development of the disease.

Is there a genetic explanation as to why children, especially firstborns, look like their fathers?

Well, it is not always the case. Physical characteristics of the offspring sometimes might be a mixture of both the mothers and fathers characteristics. There are, however, extremes where a child may look like a copy of either parent. A child is a result of the union of genes of a mother and father, and the strength of expression of these genes may differ.

There is conflicting information out there about genetically modified foods. What are the facts and fiction on this?

Genetically modified foods refer to food items whose source material production, be it plant or animal, involves intentional mixing (manipulation) of genetic material not naturally found in the pure/natural breed.

The fuss brought about by anti-GMO campaigners has been related, in my opinion, to a lack of information. The genes being included have their function known from a science point of view. However, genes may interact and the results may not be known fully. How a gene will behave in the new organism is assumed to be what is known, but it does not rule out undesired effects. However, before a gene is used in GMO, experimental tests are usually performed to understand different scenarios under which it may elicit undesired effects.

Dr Fredrick Nindo, a geneticist, is a visiting post-doctoral research fellow at the Mediterranean Infection Institute for Research in Cancer and Ageing, France.

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Ask the doctor: Is there a chance I am not my sons father? - The Standard

Breast Cancer Predictive Genetic Testing Market 2020, by Tools, Services, Business Application, Company Profiles, Trends, Demand and Investment Opportunities to 2026

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Global Breast Cancer Predictive Genetic Testing Market Leading Players:Roche, Thermo Fisher Scientific, PerkinElmer, Quest Diagnostics, Myriad Genetics, Iverson Genetics, Cancer Genetics, OncoCyte Corporation, NeoGenomics, Invitae

Global Breast Cancer Predictive Genetic Testing Market Product Type:High Penetrant Genes, Intermediate Penetrant Genes, Low Penetrant Genes

Global Breast Cancer Predictive Genetic Testing Market Application Segment:Hospitals, Clinics, Others

Breast Cancer Predictive Genetic Testing Market Report Highlights The report provides a detailed analysis on current and future market trends to identify the investment opportunities Market forecasts till 2026, using estimated market values as the base numbers Key market trends across the business segments, Regions and Countries Key developments and strategies observed in the market Market Dynamics such as Drivers, Restraints, Opportunities and other trends In-depth company profiles of key players and upcoming prominent players Growth prospects among the emerging nations through 2026 Market opportunities and recommendations for new investments

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Global Breast Cancer Predictive Genetic Testing Industry Developments & Assessment 2020-2026 : Roche,... - Azizsalon News

A new study has suggested that genetics could be the reason as to why some women gain weight while they're on birth control.

Many women take birth controlregularlyin order to regulate their menstrual cycle and prevent pregnancy. But like with any medication, it comes with its fair share of side effects. Some of them can be a mere nuisance whereas others can be serious or even life-threatening.

One side effect that leans towards the former is weight gain. While it can happen, it doesn't happen to every woman who goes on birth control. That can be frustrating if this side effect has happened to you. But now,a new study has revealed that genetics could determine why some women gain weight while using birth control.

The study in question was carried out by researchers at the University of Colorado Anschutz Medical Campus. They recruited 276 women to see if they gained weight while having an etonogestrel contraceptive implant inserted in their arm. Since it contains etonogestrel, it inhibits ovulation. Moreover, it's arguably the most effective method of birth control.

Related: The Strangest Myths About Birth Control Debunked

The study found that 73.9 percent of participants gained weight with theetonogestrel contraceptive implant. When they looked at just how much weight they gained, the median was 3.2 kilograms, which is just over seven pounds. That median was determined over a time span of 27 months.

After that, researchers looked into whether or not genetics played a role in why some participants gained weight, and others didn't. That study found genetic variants in estrogen receptor 1 (ESR1) were associated with weight gain. Women with two copies of ESR1 were found to have gained an average of 14.1 kilograms (over 31 pounds) while using the aforementionedcontraceptive implant.

There are currently no links found between ESR1 and obesity. However, past research had found links between ESR1 and how it affects other medications. Also, it's not yet known if ESR1 is only linked to weight gain to other forms of birth control outside the contraceptive implant used in the study. More studies will need to be conducted in order to determine this. That being said, this is a great start looking into this particular matter.

"For years, women have said that birth control causes them to gain weight but many doctors failed to take them seriously.Now we have looked at the genetics and found that the way genes interact with some hormones in birth control could help explain why some women gain more weight than others," explained Aaron Lazorwitz, Md., the study's lead author.

Next: Hailey Bieber Admits That Starting Birth Control Lead To Acne Breakouts

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Elizabeth Sarah Larkin is a full-time freelancer who specializes in writing, social media, and public relations. She has published articles for many online publications, including Babygaga and Moms.com. She graduated from Conestoga College with a Bachelor of Public Relations (Honours), where she learned and honed her skills. Her interests include music, video games and working out. You can follow her on Twitter (@ElizabethSL95) or Instagram (@elizabethsarahl); or you can contact her at elizabeth@elizabethsarahlarkin.ca

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Study Suggests That Genetics Could Be Why Some Women Gain ...

May 19 (UPI) -- African-American and white women share several genetic mutations that increase risk for breast cancer, according to a study published Tuesday by the Journal of the National Cancer Institute.

Researchers at Boston University and the Mayo Clinic found that mutations of the BRCA1, BRCA2 and PALB2 genes, which are known to raise breast cancer risk in white women, including those of Ashkenazi Jewish descent, are also found in African-American women with the disease.

The genetic mutations have been associated with a more than seven-fold higher risk of breast cancer, the researchers noted.

"We also found that mutations in PALB2, RAD51C and RAD51D confer increased risks of estrogen receptor negative breast cancer in the African-American population," study co-author Fergus Couch, the Zbigniew and Anna M. Scheller Professor of Medical Research at the Mayo Clinic, said in a statement.

About one out of every eight women in the United States will develop invasive breast cancer during their lifetimes, according to BreastCancer.org. African-American women tend to be diagnosed at a younger age and are more likely to die from the disease.

However, rates of breast cancer genetic testing are substantially lower in African-American women than in white women, the authors of the JNCI study said. Differences in health recommendations given to African-American women have been identified as one of the drivers of this disparity, they added.

For the study, Couch and his colleagues sequenced germline DNA from 5,054 African-American women with breast cancer and 4,993 age-matched African-American women without cancer, looking for mutations in 23 genes believed to predispose women to the disease. The researchers then estimated the risk of developing breast cancer associated with having a mutation in any of the genes.

They found that more than 7 percent of women with breast cancer, regardless of race, had a mutation in one of the genes, as compared with 2 percent of the controls. Among women with breast cancers that lacked estrogen receptors -- or had estrogen receptor negative breast cancer -- more than 10 percent had a mutation in one of these genes.

In comparison, 5 percent of women with estrogen receptor positive breast cancer had a mutation in the cancer-related genes.

In addition to common mutations of the BRCA1, BRCA2, PALB2, RAD51C and RAD51D, the authors identified four other genetic mutations associated with a more moderate increase in risk for breast cancer among the women in the study. Previous studies of women of African ancestry were too small to identify genetic mutations other than those affecting BRCA1 and BRCA2.

Based on these findings, testing for breast cancer predisposition genes can prevent breast cancer deaths -- both in women who have never had breast cancer and in women with breast cancer -- according to the researchers.

"The multi-gene panels that are currently available to test women diagnosed with breast cancer or women at high risk due to their family history will be useful for African American women," said co-author Julie Palmer, director of Boston University's Slone Epidemiology Center.

"Depending on results of the testing and an individual's own weighing of pros and cons, a woman with a mutation in any of these genes may choose more aggressive screening for cancer, and women with mutations in the high risk BRCA1 and BRCA2 genes may choose removal of her breasts and/or ovaries as a way to prevent initial breast cancer or recurrence," she added.

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African-American, white women share genetic mutations ...

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Abbott Laboratories, Bio-Rad Laboratories, Inc

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Genetic Testing Market Is Booming Across the Globe Explored in Latest Research with Top Key PlayersAbbott Laboratories, Bio-Rad Laboratories, Inc -...

BILLINGS Before the COVID-19 pandemic, way back in the 1300s there was a pestilence known as the Black Death, also called bubonic plague.

Estimated to have killed millions during several outbreaks, the bubonic plague is caused by a bacteria known as Yersinia pestis.

Although the new coronavirus pandemic has captured headlines and attention around the world over the past two months, bubonic plague has again reared its head, this time in the Greater Yellowstone Ecosystem. Recently published research by Mark Elbrock and his associates showed 47% of the 17 cougars that were captured and had their blood drawn in the southern GYE tested positive for exposure to the plague.

This suggests that: (1) Y. pestis may be present at higher levels in the GYE than previously assumed, Elbrock wrote in the Cambridge University Press, noting that the disease was also found in four of 11 mountain lions that were necropsied. His co-authors were Winston Vickers and Howard Quigley.

The study is not the first time that exposure to Y. pestis has been found in Greater Yellowstone Ecosystem cougars. In 2006, a study co-authored by Roman Biek and Toni Ruth, along with others, tested blood from 150 cougars collected over 15 years and found relatively low exposure to the bacteria less than 20%.

Ruth also found Yellowstone cougars in 2004 and 2005 that had succumbed to bubonic plague. When captured in the winter, they were infested with fleas. The animals died in the following summer.

Its a relatively common bacteria found in wildlife, more so in southern drier areas, said Dan Stahler, leader of the Yellowstone National Park Cougar Project.

The bacteria is commonly transmitted by fleas that infest rodents, everything from mice to ground squirrels. The cougars, along with other predators like coyotes, are exposed to the virus when they catch and eat infected animals.

Felines, including bobcats and lynxsee, tend to be more susceptible to Y. pestis than canines, Stahler said. For some reason, bears appear impervious to such infections, he added.

Being aware of contagions is why Stahler and his team approach any dead animal cautiously while conducting wildlife research.

Anyone in contact with animals needs to have such diseases at the forefront of their mind, he said.

Not to be fearful, or to panic, but its important to screen for it and be careful of it, he said.

In humans, bubonic plague causes enlarged lymph nodes in the armpits, groin and neck. It can also be accompanied by fever and muscle aches, along with other flu-like symptoms. Unlike COVID-19, it cant be transmitted from an infected person to others via respiratory droplets. Bubonic plague is also easily treated with a vaccine if caught soon enough.

According to Montana Fish, Wildlife and Parks website, detailed data on the distribution of plague in wildlife in Montana is not available, although it is believed to be present throughout the state. The most recent human case of plague in Montana was in 1992 when a hunter contracted the disease from a bobcat. In 1987, a hunter was infected after skinning an infected antelope.

Across the United States, only about seven people a year are infected, according to the Centers for Disease Control and Prevention. More prevalent in the Southwest, the United States saw spikes in human infections in 2006 and 2015, according to the CDC.

Prairie dogs are another species that is often infected by bubonic plague. In trying to reintroduce black-footed ferrets across the West, outbreaks of plague have repeatedly frustrated scientists efforts. Prairie dogs are the main food source for the ferrets, which also use the rodents dens as their living quarters.

The incidence of plague seems to increase in years with cooler summers that follow wet winters, Stahler said, possibly because those conditions are more conducive to flea survival.

Yellowstone National Parks cougar study continued this winter with the capture of seven cougars. Eight of the big cats are wearing GPS collars, allowing researchers to track their movements.

Soon-to-be published research based on a graduate students work on noninvasive genetic testing, like hair samples, is being used to provide insight to the parks cougar population. Stahler said the work shows that in the Northern Range of the park, which includes the Lamar Valley, there are about 35 to 45 cougars, a robust population.

The research team also continues to collect data via remote camera traps, which also will help with population estimates of the secretive animals. At one elk calf carcass, five lions were photographed feeding over several days.

We had one cool trigger where a mule deer went racing by and was then followed by a cougar, Stahler said.

Another series showed a whitetail deer racing past a camera near Hellroaring Creek, soon followed by a wolf. The wolf later walked back past the camera.

Unfortunately, the parks winter predator study was cut short in mid-March due to the coronavirus pandemic, Stahler said. Yellowstone National Park was closed to the public on March 23.

We decided to get our people home safely, he said.

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Tale of bubonic plague in pumas revived by southern Yellowstone study - Sports and Weather Right Now

Trusted Business Insights answers what are the scenarios for growth and recovery and whether there will be any lasting structural impact from the unfolding crisis for the Hereditary Testing market.

Trusted Business Insights presents an updated and Latest Study on Hereditary Testing Market 2019-2026. The report contains market predictions related to market size, revenue, production, CAGR, Consumption, gross margin, price, and other substantial factors. While emphasizing the key driving and restraining forces for this market, the report also offers a complete study of the future trends and developments of the market.The report further elaborates on the micro and macroeconomic aspects including the socio-political landscape that is anticipated to shape the demand of the Hereditary Testing market during the forecast period (2019-2029).It also examines the role of the leading market players involved in the industry including their corporate overview, financial summary, and SWOT analysis.

Get Sample Copy of this Report @ Hereditary Testing Market Size, Market Research and Industry Forecast Report, 2020-2026 (Includes Business Impact of COVID-19)

Industry Insights, Market Size, CAGR, High-Level Analysis: Hereditary Testing Market

The global hereditary testing market size was valued at USD 5.8 billion in 2019 and is projected to register at a CAGR of 6.3% during the forecast period. The expanding reproductive genetic health space is one of the key market drivers. Key players, such as Natera, have reported a continuous increase in test volumes in womens health genetic testing for inherited conditions. This reflects the growing acceptance of hereditary tests among the population, thereby accelerating the revenue growth.Furthermore, a consistent rise in demand for newborn screening has led to an increase in sales of DNA testing kits. For instance, in November 2019, the Division of Consolidated Laboratory Services (DCLS) of the Virginia Department of General Services screened 7,868 newborns for nearly 31 hereditary and metabolic disorders. Increasing penetration of newborn screening across the globe is further aiding in the revenue growth.

Reforms in genetic testing guidelines have led to inclusion of multigene panel testing for hereditary cancer into clinical practice. The National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (NCCN Guidelines) for breast, ovarian, and colorectal cancers offers information on some of the cancer risk factors and management recommendations for single and multiple gene panels.Gradual developments in the distribution model is likely to benefit the genetic testing market. Technology providers are playing a crucial role in the market growth by improving their distribution service and increasing the efficiency of technology. Companies are using a cloud-based distribution model to make bioinformatics technology available for use by other laboratories. As of March, 2019, around 14 licensees were using Constellation software commercially for the marketing of Non-invasive Prenatal Testing (NIPT) products.Although these hereditary tests have huge advantages over conventional tests, several industry experts cited the cost and security concerns faced by consumers pertaining to the test. Moreover, lack of effective regulation of the tests is another key area that demands focused efforts. Despite these challenges, the genetic testing market is constantly expanding owing to the advantages of these innovative tests along with improved healthcare outcomes.DiseaseType Insights of Hereditary Testing Market

Product and service offerings with regard to various hereditary cancer testing continue to expand. Entry of major players, such as Quest, in this segment in the recent past, has significantly driven the hereditary testing market. Considering breast cancer genetic testing as a lucrative source of revenue, companies are focusing on business strategies to enhance their presence in this segment.One of the strategies is offering hereditary tests at a price lower than that offered by competitors. For instance, Color Genomics began selling its product for USD 259, whereas similar products offered by Myriad cost around USD 4,000. The increasing affordability of the tests is one of the key drivers of this segment. Furthermore, BRCA1 carriers have an 80% risk of developing breast cancer, which has also accelerated the developments in hereditary cancer testing market.

On the other hand, lung cancer is one of the major cancer forms that has a relatively few number of products. This is because most cases of lung cancer are not related to inherited genetic mutations. Similarly, for cervical cancer, most of the cases are caused by Human Papilloma Virus (HPV) and not genetic mutations. Lack of effective evidence over heritability of cervical cancer are driving the research activities in this market.Prenatal testing, irrespective of the associated risks, is increasingly gaining popularity. The cell-free DNA (cfDNA)-based NIPT testing is considered medically necessary by Anthem Blue Cross and Blue Shield of California. Previously, these players promoted cfDNA-based NIPT testing for trisomys 21, 18, and 13 only in high-risk pregnancies, as determined by maternal age and other factors.

Regional Insights of Hereditary Testing Market

Variations in regulatory frameworks pertaining to genetic tests across the world have significantly impacted the approval and commercialization of tests in the global market. Currently, a wide variety of genetic tests are being provided by several key companies in U.S. as well as several countries in Europe, Asia Pacific, and other regions.Europe accounted for the largest share in terms of revenue in 2019 and is likely to continue its dominance during the forecast period. This can be attributed to presence of key players providing genetic tests, high adoption of advanced treatments, and recommendations provided by government agencies to ensure the quality of hereditary testing services.In September 2019, Blueprint Genetics, a Finnish company, partnered with ARCHIMEDlife, a rare disease diagnostics company, to provide biochemical testing for rare diseases in North America. Through this partnership, both firms planned to diversify their range of genetic disease testing services to serve the customers better. Such initiatives are expected to strengthen the genetic testing scenario for hereditary disorders in North America, thereby accelerating regional revenue generation.

Market Share Insights of Hereditary Testing Market

Understanding the role of genetic mutation in disease occurrence has significantly accelerated the R&D in this market. Various retrospective studies are being carried out to understand the role of inherited mutations in disease pathology, which has led to key diagnostic developers, such as Quest Diagnostics, enter the market. Continuous authorizations and approvals of genetic tests by the government is expected to propel the organic revenue growth of operating companies.Some of the key players engaged in offering services and products in this market are Myriad Genetics, Inc.; Invitae Corporation; Illumina, Inc.; Natera, Inc.; Laboratory Corporation of America Holdings; F. Hoffmann-La Roche Ltd; Quest Diagnostics Incorporated; CooperSurgical, Inc.; Agilent Technologies, Inc.; Thermo Fisher Scientific, Inc.; Twist Bioscience; Sophia Genetics; Fulgent Genetic, Inc.; Medgenome; and CENTOGENE N.V.Furthermore, the expanding product portfolio is indicative of growing competition in the market. Each company is making focused efforts to offer products with competitive advantage. For example, cross-selling efforts by Natera helped the company witness lucrative revenue generation over the past years. The company promotes collective use of Horizon and Panorama products for women who have not undergone carrier screening tests in their first trimester.

Segmentations, Sub Segmentations, CAGR, & High-Level Analysis overview of Hereditary Testing Market Research ReportThis report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2015 to 2026. For the purpose of this study, this market research report has segmented the global hereditary testing market report on the basis of disease type and region:

Disease Type Outlook (Revenue, USD Million, 2019 2030)

Hereditary Cancer Testing

Lung Cancer

Breast Cancer

Colorectal Cancer

Cervical Cancer

Ovarian Cancer

Prostate Cancer

Stomach/Gastric Cancer

Melanoma

Sarcoma

Uterine Cancer

Pancreatic Cancer

Others

Hereditary Non-cancer Testing

Genetic Tests

Cardiac Diseases

Rare Diseases

Other Diseases

Newborn Genetic Screening

Preimplantation Genetic Diagnosis & Screening

Non-invasive Prenatal Testing (NIPT) & Carrier Screening Tests

Quick Read Table of Contents of this Report @ Hereditary Testing Market Size, Market Research and Industry Forecast Report, 2020-2026 (Includes Business Impact of COVID-19)

Trusted Business InsightsShelly ArnoldMedia & Marketing ExecutiveEmail Me For Any ClarificationsConnect on LinkedInClick to follow Trusted Business Insights LinkedIn for Market Data and Updates.US: +1 646 568 9797UK: +44 330 808 0580

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Hereditary Testing Market 2020: Global Industry Analysis By Size, Share, Growth, Trends And Forecast To 2026 - Cole of Duty

In the big leagues hes known as a dependable reliever.

Once a star pitcher at Wright State and now a stalwart of the Houston Astros bullpen, Joe Smith is awaiting the start of his 14th Major League Baseball season.

Hes appeared in 782 games and is known for his unique delivery, a cross between sidearm and submarine style.

But its his pitch off the mound even more so than on it thats especially impactful.

Were just trying to bring some good into the world, he told me the other day when discussing one of his charitable involvements.

Smith and his wife Allie LaForce the former Miss Teen USA, an Ohio University basketball player and journalism grad and now a TNT sideline reporter known for her coverage of the NBA and college basketball March Madness are the highest profile sports couple in the Miami Valley.

They live in Bellbrook in the offseason, though their careers have them travelling around the country much of the year.

At present theyre ensconced in West Palm Beach. Smith went to Florida for spring training and was joined by Allie when the COVID-19 pandemic shut down the sports world over two months ago.

Since then they have been doing some real relief work.

With the help of the Athletes and Causes, the nonprofit organization that runs their charitable ventures, they became the driving force of the Project FRONTLINE effort that has delivered over 15,000 meals from restaurants struggling through the coronavirus closures to over-taxed doctors, nurses and hospital staff.

Were just trying to say a little thank you to those people who are making sacrifices and risking their lives for the rest of us, Smith said. At the same time were getting local restaurants involved and giving them some revenue so hopefully they can pay some employees and keep their doors open.

While the couple made a considerable monetary commitment to the venture, they also got support from other pro athletes and celebrities people like fellow Astro Josh Reddick, former big leaguer Johnny Damon, Cleveland Cavalier Kevin Love, Portland Trailblazer CJ McCollum, Cleveland Indians manager Terry Francona, celebrity chef Michael Symon and others as well many everyday people.

Theyve helped hospitals in six states and especially in and around Houston and Cleveland, where Joe had two pitching stints and where Allie, who grew up some 40 miles away in Vermilion, once worked as a sports anchor and reporter at Fox affiliate, WJW Channel 8.

Their effort caught the imagination of many and spun off in some unlikely directions.

A woman from Oberlin called and said, I dont have a restaurant, but I have 1,000 orchid plants Id like to donate. Do you think nurses would want one? Allie said.

We had them shipped to our (Athletes and Causes) headquarters in Tampa and they gave them out. And we heard stories how some nurses were in tears knowing someone cared about them.

While immersed in this project, theyve continued work with their signature HelpCureHD Foundation.

The HD is for Huntingtons Disease, the congenital disorder that causes the progressive breakdown of nerve cells in the brain and erodes mental capacity and physical capability.

There is no cure and it is usually fatal.

Joes grandmother died from HD complications in 2006 and his mother, Lee, a former elementary school teacher in her early 60s, was diagnosed with it eight years ago and for the past 2 years has lived in an Alzheimers facility near Cincinnati.

Theres a 50 percent chance that Joe and his sister Megan could inherit the disease.

When he and Allie began the foundation, the goal was to raise awareness and provide financial backing for research. In recent years the focus has switched to helping families attempt costly in vitro fertilization with genetic testing that would help them end up with HD-free embryos to be implanted.

That not only would guarantee an HD-free child, but it would stop the devastating disease from continuing its generational chain.

They had planned to do the process themselves in April, but precautions against COVID-19 prevented those medical procedures. Thats made it especially tough this month since May is Huntingtons Disease Awareness Month.

They want to help families because the costs are steep. Smith said they already have spent $47,000 in their own attempt and it can be $8,000 with every doctors visit.

Were lucky because I play baseball, but few families can afford that, he said. And a lot of its not covered by insurance. Itd be emotionally devastating to know you couldnt help your child or future generations just because of finances.

He said HD is like a combination of Alzheimers, Parkinsons and ALS:

Its the Devils Disease.

A true love story

And yet something quite angelic has been happening, Allie said:

Joes dad cant get in to see Joes mom, so he sits outside of her window every single day just so she can see him. Hes an incredible man and its a true love story.

Joes mom really isnt talking anymore, but she gets up and sees him out there and they have lunch together.

Although she said Joes mom is losing her memory and motor skills, she likes those visits. Nurses will hold a phone up to her ear and Mike, her husband of 39 years, talks to her.

She always been her sons biggest fan and over the past couple of years the family has taped his night games and played them for her the next day.

That makes these days without baseball especially tough for her.

Allie said there were times when his moms condition first began to worsen that Joe struggled with being away from her to play baseball:

He got to a point where he was questioning: Why am I playing the game? He wasnt feeling any fulfillment at the core of himself.

But then when he found that our foundation could help families get HD-free babies and change a familys future, he realized the platform and the financial capabilities he had with baseball. He started to feel a new fulfillment. That made the game worth it again.

Smith said he knows some peoples beliefs dont allow them to go along with this and thats fine But for me, this is a chance to get rid of a terrible disease.

Youre not changing eye color or height or anything else about the human being. Youre just knocking the Huntingtons gene out.

They had 24 families in their program when the pandemic put everything on hold. But recently they got word that two families one in Ohio, one in Houston have HD-free pregnancies.

That was a really rewarding moment, Smith said. Thats what were trying to do here. Were just trying to bring some good into the world.

Giving back

With their round-the-calendar careers she covering basketball and football, he playing baseball Allie said these have been the first weekends theyve had off together since they married in 2015.

While she said it was awesome for their relationship, they were even more intent on looking out for others.

I think it has to do with both of our upbringings, she said. In my hometown, my parents would run steak fries to raise money if somebody in our high school or community was in need. I can remember working at them growing up.

And when I was Miss Teen USA, I was like 16 and went all over the country raising over $100 million for different charities.

Smith continues to embrace the Wright State program which he joined as a walk-on out of Amelia High School near Cincinnati. He became the Horizon League Pitcher of the Year and in 2006 was a third-round draft pick of the New York Mets.

His career took him to Cleveland, the Los Angeles Angels, Chicago Cubs, Toronto, back to Cleveland and in December of 2017 he signed with the Astros. He suffered a ruptured Achilles in a workout the following December and pitched just 25 innings in the latter part of last season, but still had a 1.80 era.

This past December, three months shy of 36, he re-signed for $8 million over two years.

He said he was impressed with the Astros from the start:

When I walked into that clubhouse in 2018, it was unbelievable. Everybody was looking for ways to give back to the community. A lot of it had to do with the way (Hurricane) Harvey hit the city (in 2017.) They understood what people were going through and tried to help anyway they could.

Now Project FRONTLINE which sent hundreds of meals to places like the Lyndon B. Johnson Hospital and Texas Childrens Hospital is continuing that communal embrace.

And if you want to donate to either Project FRONTLINE orHelpCureHD, go toathletesandcauses.org and follow the prompts.

Back to baseball?

As restrictions are being eased across the nation, preliminary talks have begun about baseballs return this season. Last week Major League Baseball presented a 67-page proposal to the Players Association that addressed some issues.

Its going to be different, but the feeling I get from everybody (players and management) is that they all want to get back on the field and start playing, Smith said. But there are so many questions to be answered:

Whats spring training going to look like? And the regular season? Where will teams play? What will travel be like? And then theres the economic issues.

And one thing cant be overlooked here. It takes a lot more than 25 young guys running around to play baseball.

We have four coaches who are 70 years old and technically in that high-risk category. There are trainers, front office people and so many others in that group, too. We need to keep them safe.

And weve got guys in our league who are literally taking care of their families. Some have 10 people living with them. Some have their parents living with them. God forbid, you bring the virus home because one of your teammates was careless.

But on the flip side, theres also a woman in her early 60s for whom hed certainly like to be back on the field.

For all her physical struggles and cognitive issues, his mom knows exactly what hes doing, Allie said:

She knows if he had a good game or a bad one. She knows how many batters he faced. How many strikeouts he got. She loves her son so much. She knows just what hes doing.

She knows his pitch.

She knows, in so many ways, he and his wife Allie are just trying to bring some good into the world.

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Archdeacon: Trying to bring some good into the world - Dayton Daily News

Eighteen years ago, former Alabama football coach Gene Stallings made a difference in the life of a grieving woman and her beautiful newborn.It's a story about love and compassion, a story that has not been told until now.This is the story of The Coach and Little Grace:Her heart was heavy on Mother's Day 2002.Laura Davis was depressed and confused as her first child slept at her side.Was she crazy to feel so sad? So hopeless? After all, her daughter Grace was a mere 14 days old. Laura Davis was supposed to be happy.As Grace slept, Laura asked God for answers. How was she supposed to care for a child with Down Syndrome? How was she supposed to see the future as her child had just been diagnosed with two holes in her heart? How was she supposed to have hope when her doctor told her that little Grace would never walk, talk or read?Her husband was doing his residency in Columbus, Ohio, and while Chris was working hard, Laura cried. She was overwhelmed. She missed her hometown of Vestavia Hills. She missed talking about life and Bama football with her friends.And getting out of bed? It just wasn't happening.The phone rang, and Laura took a deep breath, inhaling tears that had fallen from her eyes."Hello," said Laura."Hello, Laura, this is Gene Stallings. I wanted to call to wish you a Happy Mother's Day."Laura's heart jumped.Was it really THE Gene Stallings? The head coach of her beloved Crimson Tide?Why in the world was Gene Stallings calling Laura Davis, who was in Columbus, Ohio?"I also want to congratulate you on your newborn, Grace," the Tide coach said.How in the world did Coach Stallings know about Grace?The two exchanged pleasantries, and then Stallings revealed why he was really calling: To give Laura Davis hope. To get her out of bed.The coach proposed a question to Laura:"What is the one thing that you want for little Grace? You want her to someday go to heaven, right?""Of course," Laura replied.And then came just one of many bits of advice that the coach offered up:"Well, Laura, Grace has a one-way ticket because God loves her and so do you," he said. "You may not know this right now, but you are in for the ride of your life. You will never stop loving little Grace."And another piece of advice from the coach:"If the Lord asked me if I would rather have had John Mark the way he is or had him as a 'normal' child, I would tell Him that I would rather have had Johnny just the way he is."Coach Stallings said "goodbye" and hung up the phone.The tears in Laura's eyes returned. But this time they were happy tears. She had chill bumps.Little Grace remained next to her, asleep.We never know when that moment might come, but on Mother's Day 2002 that moment came for Laura Davis.She closed her eyes and prayed, promising God that she was going to make the most of Grace's life and offer her daughter every ounce of love that she could muster.And suddenly, good things started to happen:The two holes in Grace's heart closed on their own.Grace smiled.Physical therapy began, then speech therapy.Laura and Chris would move back to Vestavia Hills as Grace turned two. Years of hard work followed. Reading, writing, speaking.Vestavia Hills' special education teacher Jennifer Greer came into their lives and Grace blossomed as a cheerleader, a student and a friend.God was good.And now for the cherry on top:Three days ago, Grace Davis, the girl who was doubted, mocked, and given little chance to live a fulfilling life, graduated from Vestavia Hills High School. Grace will enter Auburn's "Eagles" program this fall. Yes, 18 years after doctors doubted her, Grace Davis will be going to college.Chris and Laura Davis are enjoying life in Vestavia Hills. Chris is an ENT doctor, and their sons Jack and Will are growing fast.Laura tells me that she will never forget Mother's Day 2002, the day that she received an unexpected phone call not from a football legend, but rather from the father of a Down Syndrome child.It was a phone call that motivated Laura to get of bed and look to the future one that ended up being more amazing than she could have ever imagined.And now you know the story of The Coach and Little Grace.A story with a happy ending!

Eighteen years ago, former Alabama football coach Gene Stallings made a difference in the life of a grieving woman and her beautiful newborn.

It's a story about love and compassion, a story that has not been told until now.

This is the story of The Coach and Little Grace:

Her heart was heavy on Mother's Day 2002.

Laura Davis was depressed and confused as her first child slept at her side.Was she crazy to feel so sad? So hopeless? After all, her daughter Grace was a mere 14 days old. Laura Davis was supposed to be happy.

As Grace slept, Laura asked God for answers. How was she supposed to care for a child with Down Syndrome? How was she supposed to see the future as her child had just been diagnosed with two holes in her heart? How was she supposed to have hope when her doctor told her that little Grace would never walk, talk or read?

Her husband was doing his residency in Columbus, Ohio, and while Chris was working hard, Laura cried. She was overwhelmed. She missed her hometown of Vestavia Hills. She missed talking about life and Bama football with her friends.

And getting out of bed? It just wasn't happening.

The phone rang, and Laura took a deep breath, inhaling tears that had fallen from her eyes.

"Hello," said Laura.

"Hello, Laura, this is Gene Stallings. I wanted to call to wish you a Happy Mother's Day."

Laura's heart jumped.

Was it really THE Gene Stallings? The head coach of her beloved Crimson Tide?

Why in the world was Gene Stallings calling Laura Davis, who was in Columbus, Ohio?

"I also want to congratulate you on your newborn, Grace," the Tide coach said.

How in the world did Coach Stallings know about Grace?

The two exchanged pleasantries, and then Stallings revealed why he was really calling: To give Laura Davis hope. To get her out of bed.

The coach proposed a question to Laura:

"What is the one thing that you want for little Grace? You want her to someday go to heaven, right?"

"Of course," Laura replied.

And then came just one of many bits of advice that the coach offered up:

"Well, Laura, Grace has a one-way ticket because God loves her and so do you," he said. "You may not know this right now, but you are in for the ride of your life. You will never stop loving little Grace."

And another piece of advice from the coach:

"If the Lord asked me if I would rather have had John Mark the way he is or had him as a 'normal' child, I would tell Him that I would rather have had Johnny just the way he is."

Coach Stallings said "goodbye" and hung up the phone.

The tears in Laura's eyes returned. But this time they were happy tears. She had chill bumps.

Little Grace remained next to her, asleep.

We never know when that moment might come, but on Mother's Day 2002 that moment came for Laura Davis.

She closed her eyes and prayed, promising God that she was going to make the most of Grace's life and offer her daughter every ounce of love that she could muster.

And suddenly, good things started to happen:

The two holes in Grace's heart closed on their own.

Grace smiled.

Physical therapy began, then speech therapy.

Laura and Chris would move back to Vestavia Hills as Grace turned two. Years of hard work followed. Reading, writing, speaking.

Vestavia Hills' special education teacher Jennifer Greer came into their lives and Grace blossomed as a cheerleader, a student and a friend.

God was good.

And now for the cherry on top:

Three days ago, Grace Davis, the girl who was doubted, mocked, and given little chance to live a fulfilling life, graduated from Vestavia Hills High School.

Vestavia Hills City Schools

Grace will enter Auburn's "Eagles" program this fall. Yes, 18 years after doctors doubted her, Grace Davis will be going to college.

Chris and Laura Davis are enjoying life in Vestavia Hills. Chris is an ENT doctor, and their sons Jack and Will are growing fast.

Laura tells me that she will never forget Mother's Day 2002, the day that she received an unexpected phone call not from a football legend, but rather from the father of a Down Syndrome child.

It was a phone call that motivated Laura to get of bed and look to the future one that ended up being more amazing than she could have ever imagined.

And now you know the story of The Coach and Little Grace.

A story with a happy ending!

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Coach and Little Grace: Mother of child with Down Syndrome gets life-changing phone call - WVTM13

By Deepak Chopra, Rudolph E Tanzi, Michelle Williams, Ryan Castle, William C Bushell, Kimberly Brouwer and Paul J Mills

The Covid-19 pandemic has brought with it a second pandemic, not of disease but of stress. We all feel stress as added pressure. This pressure registers psychologically as worry and anxiety, while the body responds with stress hormones. The overall stress response is designed to be a short-term reaction. When stress persists, however, it enters into the mix of threats posed by Covid-19.

So what can the average person do to reduce the threat?

We advocate meditation, yoga, and deep regular breathing (Pranayama), which are practices available to anyone. They can be easily done at home, with the intention of returning to a relaxed, balanced state. Paying attention to stress is always advisable, but doubly so during this crisis. There is a specific connection that wed like to explain.

First, a little background. Although Covid-19 is very easily transmitted from person to person, the risk of being hospitalised or dying primarily affects people who are already at risk because of old age, infirmity, or chronic diseases such as cancer, diabetes, autoimmune illness, obesity, and heart disease. All of these chronic illnesses are associated with measurable low grade inflammation in the body.

The chronic low-grade inflammation that develops with advanced age has become known as inflammaging. Most people with chronic illness unknowingly have low grade inflammation. Recent research points to a second finding: These same disorders are often accompanied by persistent low grade anxiety and depression.

In a crisis like the current pandemic, anxiety and depression also begin to affect healthy people due to stress. It has become increasingly evident that low level inflammation and chronic stress lie at the heart of many disorders that take years or even decades to develop before symptoms appear that can be treated by a physician.

Against this background, which pertains to countless people in modern society, there is increased danger when acute illness strikes. In addition to the elderly and chronically ill, Covid-19 is causing acute respiratory illness and stroke sometimes leading to death in seemingly otherwise healthy younger people. The transition from SARS-CoV-2 infection to being diagnosed with Covid-19 is typically accompanied by a so-called cytokine storm. Cytokines are proteins that are major drivers of inflammation, and their rapid increase, or storm is one of the bodys immune responses to acute threat.

In addition, studies have connected pro-inflammatory cytokines to the stress response; they regulate well-known stress hormones such as ACTH and cortisol. Three major systems are involved: the immune system, central nervous system and endocrine hormone system.

In the face of these connections, we are coming forward to suggest that complementary practices deep breathing, yoga and meditation can play an important role during this pandemic. These practices have been confirmed by hundreds of scientific studies to bring down over-activity of the autonomic nervous system, calm the mind from anxiety, reduce the stress response, regularise heartbeat, and lower blood pressure. Together, all of these diverse benefits are associated with reducing the invisible presence of chronic low-grade inflammation, especially if added to good sleep, exercise and proper diet.

We dont fully understand how the immune response, linked to stress and inflammation, can turn lethal. As a response to cuts, wounds, invading pathogens, and other threats, prior to antibody formation, the body first responds with inflammation as a normal yet crucial healing function. But it has long been known that inflammation is paradoxical. Acute inflammation can overreact, harming or even killing the patient. (Instances of strokes and heart attacks among young Covid-19 patients might be linked to micro-cytokine storms in the brain and heart.)

The threat from low-grade chronic inflammation was not discovered until recently but seems to be widespread. It is unaccompanied by swelling, burning and redness of the skin that marks acute inflammation and therefore goes undetected by the patient or physician.

Preventing and addressing chronic low-grade inflammation and its significant adverse consequences are urgent issues, even more urgent during a pandemic. There seems to be every reason to make the public aware how deep breathing, meditation, yoga and other healthy lifestyle practices can help during this crisis and long afterwards.

DISCLAIMER : Views expressed above are the author's own.

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Stress caused by Covid-19 makes us doubly vulnerable: What the average person can do about it - Economic Times

Even though male balding is almost as inevitable as gravity, celebrities simply do not like to speak on the IP behind their dramatic hair restoration innovations. What is verifiable, however, is when Elon Musk sold PayPal in 2002 the cash transaction website that made him a billionaire he was indeed abalding man. More present day, however, he is quite the opposite. That requires some kind of scientific explanation, and with a $38.2 billion fortune,the SpaceX and Tesla founder could surely afford a consultation.

"I mean, he had a class three to a class four (out of seven) hair loss pattern and he now shows no evidence, at least in the front, of any hair loss," New York hair transplant specialist, Dr. Jefferey Epstein, told Page Six in 2018, further describing the odds that Musk went under the knife as "highly, highly likely." Epstein added that Musk may have had at least two procedures, running him between $20,000 and $30,000 a sum the engineering mogul likely located between the seats in one of his electric cars.

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Celebs who don't want you to know they're going bald - Nicki Swift

Some rhesus macaques in Agra. Photo: Thomas Schoch/Wikimedia Commons, CC BY-SA 3.0.

In the first week of May, two videos had social media agog. Both involved monkeys, one robbing a Delhi ATM and the other riding by on a bike. At first glance, these videos seem to offer brief moments of amusement in an otherwise grim time. But why bother with such trivia now? Isnt this fiddling while Rome burns?

Well, a post-coronavirus scenario will certainly require a radical reassessment of the deep, conflicted relationship between human societies and their environment, between us and them, between our habitats and theirs. That is why the monkey tricks we saw captured on video earlier this month dont just offer fleeting moments of shock or levity. They are a guide to our past and to our uncertain future.

Indians relationship with simians is the stuff of legend. Millions venerate the monkey-god Hanuman. Myths such as one about the vanara sena1 that helped King Ram build a bridge to Sri Lanka abound. Temples across the country shelter astonishingly large troupes of monkeys; Haridwar literally gods gateway in Hindi is just the most famous of these sites.

Research in the biological sciences around the world also includes substantial focus on primates. That humans share more than 90% of their DNA with the great apes implies that we share several traits with them. For this reason, vaccine trials, not excluding present ones for the coronavirus, are often conducted on primates. Even without knowing it, then, primates greatly contribute to our well being sometimes at great cost to their own.

These issues of human interaction with simians and other species have been around at least since Charles Darwins work, The Expression of the Emotions in Man and Animals (1872). In this book, Darwin examines the sphere of culture and emotion. He reports on the findings of a questionnaire that he sent to 34 countries, including India, asking how 16 different emotions are expressed across cultures. Through this exercise, Darwin sought evidence for his view that all humans share basic emotions with animals owing to a common evolutionary ancestry. Few will deny that we are witnessing such emotions come to the fore in a heightened manner during the present crisis.

In our research at IIT Delhi, based partly on Darwins insights in the Emotions volume, we investigated the feelings that humans, especially children and their caregivers, experienced as they navigated the seas of social survival. The video below documents a small part of what we discovered, by focusing on a mature female monkey, specifically a rhesus macaque (Macaca mulatta).

As viewers will notice, the baby that the monkey mother is holding is actually a puppy. She kisses and fondles it, runs away when she thinks her child is in danger, takes shelter with her partner and another male, possibly her brother, who support her decision to adopt this baby. We observe emotions such as love, trust, bravery, fear, panic, anxiety, anticipation and so on throughout the video.

It happens that this particular simian mother cant have children of her own because male monkeys in the area have been clinically neutered. So she steals a puppy from the locality and attempts to bring it up as her own. In our footage, she hardly lets go of her baby for an instant, bolting as fast as her heavy and precious burden will allow, especially when the alpha male is nearby.

We also hear local villagers talk about how they have witnessed this strange behaviour for some time and how the current pup is in fact one of a series, since the adopted pup always dies. This is because the simian mother treats the puppy just as she would a monkey-baby, feeding it grass and carrying it with her as she leaps from height to height. It is no surprise that the pup eventually dies from injuries and starvation.

This clip teaches us three things at a minimum.

First, it reminds us that animals and humans have shared common spaces for millennia. If we interfere with these spaces, for example by neutering male monkeys, it can have unforeseen, even dangerous, consequences. In this film, the interacting species are humans animatedly discussing the actions of monkeys; the simian troupe that have to assimilate a dog into the everyday routine of their lives; and the small pup at the still centre of this cross-species drama.

Today, we need to understand and respect these relationships (with bats, rats, tigers, bees, bacteria, viruses and plants) more than ever because they determine who we are.

The fact is that we are beings designed by nature for touch-contact with each other as well as with several animal species. Physical distancing may work as an excellent temporary survival strategy. We will, however, have to develop far more innovative ideas in proxemics studies, and invest in understanding technologies of desire and the political economy of inter- and intra-species inequality before humans manage to overcome, even in part, their ancient, touchy feely emotional coding.

Forgetfulness is biological but memorialisation cultural. Both shape us but the evidence thus far indicates that people always return to their old, bad ways after pandemics, however harrowing. It could be the triumph of hope over experience to think that the reset button will be so easy to press this time round.

Second, the video teaches us that there can be individual differences between monkeys as there are among humans. Not all monkeys choose to rear puppies as their own offspring. Not all ride bikes or investigate ATMs.

This insight is important because it tells us that our own human cultures are simultaneously composed of individuals and collectives. Both concepts have great power and potential as we move into an age in which we will have to make increasingly difficult ethical and intellectual choices about our common environment.

Third, the video shows us that humans can learn from their mistakes in a way that other species cannot. The monkey mother in the video repeatedly picks up puppies even though they die on her, remaining a prisoner of her biological instincts. That is her tragedy. Ours is different: that even though we can reflect deeply on our emotions and instincts through language, even though we have the mental capacity to acknowledge our mistakes, we fail to do so. Our greatest gift to argue passionately about something we call the truth can then become our greatest failing, making us prisoners not of our instincts but of our prejudices. That is our tragic flaw.

So it was wonderful to listen to the vociferous debate my students engaged in when I showed them our film. Some thought the macaque mother in question profoundly selfish, others that she was remarkably altruistic. Since the world recently celebrated Mothers Day, the students also debated whether a generic recognition of baby-like characteristics in pets and other creatures might help species survive by triggering a generalised protective circuitry that induces compassionate emotions.

In the 19th century, Darwin knew little about genetics but I imagine he wouldnt have been at all surprised to learn about the current virus that spilled over from bats to humans nor would he have contested the pivotal role empathy can play in preventing humans from self- and others destruction. Towards the end of The Origin of the Species, he wrote presciently:

In the distant future I see open fields for far more important researches. Psychology will be based on a new foundation.

The COVID-19 crisis has shown that we may be at the threshold of that distant future.

Rukmini Bhaya Nair is a cognitive linguist and writer. She teaches at IIT Delhi.

The author is very grateful for the funding received for the Language, Culture and Emotion project from the Department of Science and Technology (DST), 2010-2014. She was Principal Investigator; her co-PIs were Purnima Singh and C.A. Tomy. She also wishes to profusely thank the filmmaker, Muneesh Tarsem, for his work on the rhesus macaque troupe in Himachal Pradesh.

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What One Monkey Mother Could Teach Humans About Themselves - The Wire

Jason Osterstock, DMV, PhD, vice president of Zoetis and the global head for the genetics portion of the business, said ensuring each animal U.S. agriculture grows must reach its full genetic potential in order to sustainably and responsibly feed a hungry world.

It is by applying genetics and data to commercial operations, he said, so more high-quality beef can be produced.

To this end, Zoetis Genetics has released INHERIT Select, a genetic test borne of a combination of genomic technologies and advancements. The multi-breed genomic test provides predictions for commercial females and, in turn, those predictions provide genetic insights to improved replacement selection and improved breeding decisions.

Dr. Kent Andersen, Zoetis director of global beef genetics, is active on his familys Nebraska cow calf operation though he and his family live in Colorado. Andersen said replacement costs to raise a heifer to the day she has her first calf are second only to feed costs on most operations. Through identification of heifers that express greater lifetime efficiency of production, he said the herd can be frontloaded efficiently.

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Theres things behind the scenes that might be economically relevant that I might be overlooking, he said. Hence, Im likely selling some I should have otherwise kept and vice versa, keeping some I should have otherwise culled.

Andersen said choosing based on which female will be the most productive over her lifetime includes optimum mature cow size and milk production level, teat and udder quality, growth relative to sensible birth weight and, post weaning, which females will produce progeny that will convert most efficiently and produce carcasses that bring the largest premiums. While he said visual appraisal and good cowboy common sense ought not be abandoned, INHERIT can offer a look into those traits that are economically relevant.

The test, which requires an Allflex tissue sampling unit, or an ear punch, is a multibreed genetic evaluation that is designed specifically for commercial cow calf producers running a crossbreeding program. The samples should be collected on any commercial female that meet the visual criteria to be considered as a replacement. It is not, Andersen said, a way to enable commercial producers to breed and keep purebred bulls, and only data on females will be reported. INHERIT Connect, a companion product, enables bull batteries to be tested to allow for parentage determination of the daughters.

Previously, Andersen said, only purebred seedstock producers have had access to genetic evaluation. This test provides predictions for 16 traits, and while there is a tremendous amount of information available, producers are provided Zoetis Indexes to summarize the complex data into a few summaries. The Zoetis Cow Calf Index is designed for producers who sell their calves at weaning, the Zoetis Feedlot Carcass Index ranks animals based on combined genetic merit post-weaning including gain, dry matter intake, carcass weight and grade, and the Zoetis Total Return Index is an economic index that ranks animals for genetic merit across all evaluated traits.

With that one number you can access the ranking of animals from the expected net return perspective for all the evaluated traits, he said.

Genomic approximation of breed composition is also available by taking the marker information and returning a percentage of Angus or Red Angus, British (South Devon and Hereford), or Continental (Simmental, Gelbvieh, Limousin and Charolais) breeds. Other breeds that would show as unknown breed composition include Indicus, dairy and Wagyu. As far as beef on dairy calves, an Angus/Holstein cross calf could certainly be tested for authentication of breed composition but if they are over 25 percent unknown breed, the efficacy of the predictions would be compromised. In the future, Andersen said he looks toward growth and carcass information being added for beef on dairy crosses.

The bottom line, he said, is the tool can identify the strengths and weaknesses of a cowherd to improve bull selection in the future based on where emphasis ought to be placed.

Its good then for a lifetime of mating decisions, particularly for cow calf customers using synchronization and AI on their heifers and maybe even in their cows, he said. We know most of them turn out multiple sires and multiple breeding pastures. It enables more strategic thinking to get bulls matched with females to accentuate and complement the strengths but then to correct any weaknesses.

Marketing is another area that can benefit from the tool. Producers who sell replacement baldie females can authenticate the merit of the animals at time of sale and, he said, although the test is for females, it would provide information about the steer mates, offering ammunition to use in the negotiation of selling cattle.

Results are available in a spreadsheet and also in an online tool called Search Point, an online cow calf management tool that comes with the purchase of the tests. Tests are run weekly, so results are updated weekly as additional information is added from the companys seedstock partners to expand ranking and benchmarking. Additional features may also be added, including a PAP EPD for high altitude cattle.

Gabel is an assistant editor and reporter for The Fence Post. She can be reached at rgabel@thefencepost.com or (970) 768-0024.

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Multi trait genetic evaluation: No longer just for purebred and seedstock operations - Fence Post

FROM 1960 till 2020, there has been a 28-fold increase in the number of centenarians. The path to longevity is strewn with false promises of expensive elixirs, exotic supplements, and stem cell rejuvenation. Human longevity is a complex interplay between the genes, the environment and lifestyle.

Genes and longevity

The study of human longevity genes is a developing science. Scientists estimate that between 15 and 30 per cent of the variation in human life span is determined by genes, but it is not clearly understood which genes are relevant, and how they contribute to longevity. In 2015, Ancestry, a genealogy and genetics company, partnered Calico, a Google spinoff, to study data from more than 54 million families and their family trees representing six billion ancestors, and were able to tease out a set of pedigrees that included over 400 million people. These individuals were connected to one another by either a parent-child or a spouse-spouse relationship.

In 2018, they published their results in Genetics, a journal of the Genetics Society of America. The study found that the lifespan of spouses were more similar and better correlated than in siblings of opposite gender. The study concluded that life span heritability is likely 7 per cent or less, and hence the contribution of genes to longevity is even lower.

Although genes seem to have only a small influence on lifespan, they appear to play a larger role in centenarians. Hence, there are a few genetic factors that do give you a headstart in the journey to longevity.

Being a first-degree relative of a centenarian makes it more likely for you to remain healthy longer and to live to an older age than your peers. First-degree relatives are less likely at age 70 years to have the age-related diseases that are common among older adults.

Women generally live longer than men , and the number of female centenarians is more than fourfold higher than that of male centenarians. It is thought that this is due to a combination of social and biological factors. Studies on mammals and Korean eunuchs has shown that the removal of testosterone at a young age was correlated with an increase in lifespan.

Genetic studies show that centenarians have a lower genetic risk of having heart disease, stroke , high blood pressure, high cholesterol, Alzheimer's disease and decreased bone mineral density. A study on Chinese centenarians published in 2013 showed that 55 per cent have normal systolic blood pressure, 82 per cent had normal diastolic blood pressure and less than 20 per cent were on long term medication. Hence, centenarians appear to have genes that reduce that risk of age-related chronic illnesses.

Biological clock

Epigenetics is the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. One of the major mechanisms in which epigenetics manifest itself is by the process of DNA methylation, which involves the chemical modification of the DNA, thereby modifying the gene function and expression.

Through this process, certain genes can be silenced or activated and potentially impact age-related diseases such as cancer, osteoarthritis, and neurodegeneration. The biological or epigenetic clock in centenarians show a decrease in DNA methylation age, indicating that they are biologically younger than their chronological age. There is also data to suggest that although circadian rhythms deteriorate during ageing, they seem to be well preserved in centenarians, including preserved sleep quality.

Environment and longevity

Environmental factors have a large impact on longevity. Better living environment, clean food, clean water, good sanitation, reduction of infectious diseases, and access to better healthcare have resulted in significant improvement in human longevity.

Using Italy as an example of the impact of a better living environment, the average life expectancy went up from 29 years in 1861 to 84 years in 2020. The number of centenarians in Italy increased from 165 in 1951 to more than 15,000 in 2011, and the incidence of deaths occurring in those less than 60 years of age, decreased from 74 per cent in 1872 to less than 10 per cent in 2011 .

The continuous increase in lifespan in recent decades is mainly due to the advances in medical science. It is estimated that medical advances have allowed an increase in lifespan of five years in the last two decades and additional two years in the last decade.

When comparing two countries at different stages of development in 1950, the average life expectancy increase of 11 years from 68 years in 1950 to 79 years in 2020 in the USA, which was more developed in 1950, was much less remarkable than the increase of 3114 years in average life expectancy from 43 years in 1950 to 77 years in 2020 in China, which was less developed in 1950. The significant improvement in the living environment in China has contributed to the narrowing in the average life expectancy between those living in the US and China.

Lifestyle and longevity

In addition to environmental factors, lifestyle factors have an important impact on longevity. A study of more than 300,000 individuals over 7.5 years showed that individuals with social relationships have more than 50 per cent greater probability of survival compared with those with few and poor social interactions.

A study on centenarians in Utah in the US between 2008 and 2015 suggested that sleep, life satisfaction and social attachment were significant predictors of days lived. There is an extricable linkage between lifestyle and socioeconomic status. The term socioeconomic status as used in longevity studies encompass all the factors that can impact longevity including wealth, geography, education, occupation, ethnicity, cultural environment, neighbourhood environment, quality of healthcare and quality of diet. It is well established that the socioeconomic status of an individual will have a major impact on health and longevity.

A study on more than 120, 000 individuals by researchers from Harvard, published in the Circulation journal in April 2018, identified five low-risk lifestyle factors for increased life expectancy. They were: no smoking, non obese ( body mass index of 18.5 to 24.9 kg/m2), exercise (at least 30 minutes per day of moderate to vigorous physical activity, including brisk walking), low-risk alcohol consumption (5 to 15 gm/day for women and 5 to 30 gm/day for men), and a high score for healthy diet.

In this study, the projected life expectancy at age 50 years was on average 14.0 years longer among female Americans with five low-risk factors compared with those with zero low-risk factors; for men, the difference was 12.2 years.

These findings are consistent with a study on Chinese centenarians in which less than 20 per cent were smokers and less than 40 per cent drank alcohol. Hence, in general, most centenarians do not smoke, do not drink alcohol or are low-risk alcohol drinkers, are sociable, friendly, cope well with stress, are satisfied with life, have healthy diets and sleep well.

In summary, the main drivers of longevity in the first eight decades of life are the socioeconomic environment and lifestyle choices. Beyond the eighties, the inheritance of genes that defer age-related chronic diseases and a younger biological clock will help to propel these individuals beyond a hundred years.

This series is produced on alternate Saturdays in collaboration with Singapore Medical Specialists Centre

Link:
How to live to 100 - Business Times

A Pembrokeshire dairy farm is screening the genomics of its heifer calves to select the best replacements for the milking herd.

Rearing replacements is one of the biggest costs on a dairy farm - rearing a calf from birth to calving is estimated to be around 1,800.

The Hannah family believes that testing their heifers for genomic traits is where big gains can be made in their spring calving herd.

They farm at Mountjoy, near Haverfordwest, where they milk a herd of 370 mainly New Zealand Friesian dairy cows and rear 200 replacement heifers.

The farm has embarked on a project to improve the lifetime productivity of cows by selecting efficient genetics for the herd.

Working with the Welsh government's Farming Connect scheme, the business aims to rear only the most productive heifers, to prevent unnecessary costs.

The less productive animals can be sold, removing the unnecessary cost of rearing and, in turn, improving the genetics and performance of the dairy herd.

Genomic testing could help us to select the best herd replacements to match the requirements of our system," said farmer William Hannah.

We feel there are real gains to be made from this, by eliminating poor genetics so that only the very best animals are retained within the herd."

Genomic testing could help select the best herd replacements to match the requirements of the farm's system, said farmer William Hannah

Industry figures show that 14.5% of female youngstock fail to reach their first calving, whilst 33% dont make it to their second lactation.

Dairy cows dont start paying back through milk sales until after the second lactation, by which time a vast amount of money and effort have been invested.

Simon Pitt, dairy technical officer with Farming Connect, who is overseeing the project at Mountjoy, said genomic estimated breeding values can be calculated at birth.

As it has a high accuracy, a strategy that utilises these advantages can be used to determine which female calves will be the most cost effective and the most productive.

Compared to traditional herd genetics, which is 18-25% accurate, genomic testing is 50-60% accurate (SCI-Spring Calving Index), he explained.

Genomic selection offers many advantages with regards to improving the rate of genetic gain in dairy cattle breeding programs.

"One benefit of interest to this project is that genetic testing can predict a greater accuracy of predicted genetic merit for young animals," said Mr Pitt.

Health benefits are also flagged up through testing; as Mountjoy sits in a high-risk TB area, among the traits of interest are TB Advantage and calf survival index.

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Dairy farm exploits genomic testing to become more productive - FarmingUK

life-style, books,

We all know at least one couple who just make no sense, a perplexing pairing that irks and boggles us. One of them might be vivacious, gregarious, classically attractive and yet the other is a little freeze ray of misery and seems to despise socialising. So why, oh why, are they together? Neuroscience, according to Dr Hannah Critchlow, may have the answer to this eternal question, and plenty more - why we get more opinionated and closed minded as we age, how our political leanings are formed, why some couples don't even seem to like each other much. Critchlow, a British researcher, writer and broadcaster who has been described as "the female Brian Cox", lays out in her brain-bending book - The Science of Fate - just some of the recent research into determinism and the theory that we don't so much make our own decisions as inherit them. The fast-moving field of modern neuroscience will, she believes, "one day be considered as profound as Darwin's Theory of Evolution". So, what can the brain tell us about the laws of opposite attraction? Well, there's a lot more to love than what meets our eyes, and it may well involve senses we didn't know we were even using. "Scientists used to believe we only had five senses, but we're finding more and more we didn't know we had, through experiments, all the time," explains Critchlow, who found herself "happily stuck" in Noosa by the coronavirus lockdown while on an Australian book tour. One fascinating trial, carried out at the Zoological Institute at Bern University and later replicated in the US, showed that women may actually be turning the smell of potential male partners into complex information. Researchers asked men to wear the same T-shirt for a few days without washing, deodorising or eating smelly foods. A group of women were then given the appetising task of sniffing the shirts and rating them for attractiveness. The results clearly showed that women would choose the odour of men whose immune systems were highly differentiated from their own. Finding a mate with different gene variations from your own produces the strongest possible offspring; a child with the greatest resistance to a wide range of infections, and thus the best chance of survival. Just how women were able to detect their biological ideal man using optimum genetics via the smell of a stinky armpit is "quite mysterious", as Critchlow understates it. "But we are, at some level, just animals, driven by the single desire to interact in a way that will pass on our genetic material," she says. "Love, it seems, is largely a by-product of the brain circuitry that prioritises reproduction and the survival of the species." Interestingly, the sniff test does not work with men, but boys are not without their own mysteries. A study of thousands of lap dances in the US found that strippers would make almost twice as much in tips on the few days when they were at the most fertile point of their menstrual cycle. Somehow, the men just found them more attractive on those days, without having any idea why. "When it comes to sex, it seems that a choice that may feel highly personal and deeply intimate is, to a large extent, the behavioural result of our brains' coding to seek maximum opportunities for our genes to be passed on," Critchlow says. Like many of her colleagues, she has come to accept that many of the choices we make are hugely influenced by the genes given to us by our parents, and our grandparents' parents. Even the foods we like are choices driven by what our ancestors were eating, and enjoying. "Basically, we are designed to eat food when we can get it, because there might not be any around tomorrow, but now we live in a world where many of us can have whatever we want, whenever we want it, which obviously leads to obesity," she says. "Genetic mutations to encourage eating less weren't passed on because food was scarce and there was no advantage in that. Mutations that made us eat as much as possible in case there was no more are a problem now that we live in abundance. "Evolution has not caught up with Uber Eats." The reassuring sense we have that we are making our own choices is "just our brains messing with us", in much the same way that we like to perceive the sun as "rising" and "setting", when we know, scientifically, that it is just the world turning. "There is always scope for changing your mind, this is the basis for consciousness, but it's not as big as we perceive it - that scope to change is limited based on the genetics we've been given," Critchlow says. "Remember that our brains use 20 per cent of our daily energy quota to fuel this enormous circuit board, and to save energy your brain filters a lot of information, and makes assumptions, based on past experience. "Judging people in the first few minutes that we meet them is all about saving energy. "With friendship groups, or clans, people look for individuals with a similar outlook and who have similar genetics as well (unlike the way they look for sexual partners). "You are drawn to people, friends, who are genetically similar to you, so you are more likely to see the world in the same way and have the same biases. "You're saving energy because you don't have to explain things." Speaking of biases, just think how reassuring it would be to discover that people who hold political views that strike you as unjustifiable were just born that way. As Critchlow puts it, understanding that people believe in certain things, like religion or politics, because their brains were built that way, "might have massive consequences for reducing conflict at every level - as we discover more about the neurobiology of belief formation and prejudice, we might be able to boost our openness to new ideas". She quotes the work of Jonas Kaplan, Professor of Psychology at USC's Brain and Creativity Institute, who has found that activity in the amygdala, and the size of people's anterior cingulate cortex, can be used to predict whether they are liberal or conservative. His researchers were able to use brain scans to predict the political leanings of American test subjects - whether they voted Republican or Democrat - "with high sensitivity and accuracy". "It's quite incredible and it does help me to understand people a little bit more, because those who are more liberal have a less-sensitive amygdala are more able to think about collaborations and partnerships for the future, rather than being scared in the moment," Critchlow says. "Conservative types have a more reactive amygdala, and that gives them a heightened reactivity to fear. They assess risks and react conservatively. "But the fact is, both types of people are really important for our survival as a species. If we were all one type it would be a disaster, we wouldn't have moved forward as a species." This, of course, raises the interesting quote most often wrongly attributed to Winston Churchill: "if you're not a liberal when you're 25, you have no heart , if you're not a conservative by the time you're 35, you have no brain." Why would people's leanings change as they age? "There's been some research at Oxford into that, following people from the 1960s to see whether they got more conservative as they got older, and it showed a 20-point increase in conservatism by the time they were 80 years old," Critchlow says. "As you get older, you rely on more tried and tested routes within your mind, there is slightly less potential for plasticity, so you might become more risk averse. "You also start to weigh how you process information differently; you place less weight on signals from the outside world, and more weight on the internal capacity of your mind - the information you have stored there. "In a way, older people are not really listening to new ideas, because they take too much energy. They're relying on their own, refined information. Or what we think of as wisdom." Kaplan, from USC, provides the quote in The Science of Fate that most neatly sums up the way most neuroscientists now see the world, which sounds radical to most people but is, Critchlow says, very much the accepted wisdom in her academic milieu. "I don't believe in free will. The universe is deterministic,'' Kaplan says. "We aren't the authors of our own actions, because everything is caused by something prior." He is aware, however, that unlike scientists, many people would find this idea hard to live with, and adds: "Decisions are partially controlled by our emotional state, and most people find it depressing to believe that they have little or no free will, so there is a lot of value in believing in it." Critchlow says abandoning the idea of free will can actually be quite relaxing. She says she frets less about the way she parents her young son, because she's not sure there's much point worrying about it. "I tend to forget that most people don't think this way and I was chatting with my agent recently and she said 'So hang on, you really think we're really just like machines?' And I was like, 'oh yeah, that's what all of the people in my little bubble of neuroscientists think'," she says. "But I think it's an idea that will become more accepted, and it's starting to happen. "Don't forget that Darwin's theories were pretty radical there for a while."

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We all know at least one couple who just make no sense, a perplexing pairing that irks and boggles us. One of them might be vivacious, gregarious, classically attractive and yet the other is a little freeze ray of misery and seems to despise socialising. So why, oh why, are they together?

Neuroscience, according to Dr Hannah Critchlow, may have the answer to this eternal question, and plenty more - why we get more opinionated and closed minded as we age, how our political leanings are formed, why some couples don't even seem to like each other much.

Critchlow, a British researcher, writer and broadcaster who has been described as "the female Brian Cox", lays out in her brain-bending book - The Science of Fate - just some of the recent research into determinism and the theory that we don't so much make our own decisions as inherit them. The fast-moving field of modern neuroscience will, she believes, "one day be considered as profound as Darwin's Theory of Evolution".

So, what can the brain tell us about the laws of opposite attraction? Well, there's a lot more to love than what meets our eyes, and it may well involve senses we didn't know we were even using.

"Scientists used to believe we only had five senses, but we're finding more and more we didn't know we had, through experiments, all the time," explains Critchlow, who found herself "happily stuck" in Noosa by the coronavirus lockdown while on an Australian book tour.

One fascinating trial, carried out at the Zoological Institute at Bern University and later replicated in the US, showed that women may actually be turning the smell of potential male partners into complex information.

Researchers asked men to wear the same T-shirt for a few days without washing, deodorising or eating smelly foods. A group of women were then given the appetising task of sniffing the shirts and rating them for attractiveness.

The results clearly showed that women would choose the odour of men whose immune systems were highly differentiated from their own. Finding a mate with different gene variations from your own produces the strongest possible offspring; a child with the greatest resistance to a wide range of infections, and thus the best chance of survival.

Dr Hannah Critchlow, author of The Science of Fate. Picture: Simon Weller

Just how women were able to detect their biological ideal man using optimum genetics via the smell of a stinky armpit is "quite mysterious", as Critchlow understates it.

"But we are, at some level, just animals, driven by the single desire to interact in a way that will pass on our genetic material," she says.

We are, at some level, just animals, driven by the single desire to interact in a way that will pass on our genetic material.

"Love, it seems, is largely a by-product of the brain circuitry that prioritises reproduction and the survival of the species."

Interestingly, the sniff test does not work with men, but boys are not without their own mysteries. A study of thousands of lap dances in the US found that strippers would make almost twice as much in tips on the few days when they were at the most fertile point of their menstrual cycle. Somehow, the men just found them more attractive on those days, without having any idea why.

"When it comes to sex, it seems that a choice that may feel highly personal and deeply intimate is, to a large extent, the behavioural result of our brains' coding to seek maximum opportunities for our genes to be passed on," Critchlow says.

Like many of her colleagues, she has come to accept that many of the choices we make are hugely influenced by the genes given to us by our parents, and our grandparents' parents. Even the foods we like are choices driven by what our ancestors were eating, and enjoying.

"Basically, we are designed to eat food when we can get it, because there might not be any around tomorrow, but now we live in a world where many of us can have whatever we want, whenever we want it, which obviously leads to obesity," she says.

"Genetic mutations to encourage eating less weren't passed on because food was scarce and there was no advantage in that. Mutations that made us eat as much as possible in case there was no more are a problem now that we live in abundance.

"Evolution has not caught up with Uber Eats."

The reassuring sense we have that we are making our own choices is "just our brains messing with us", in much the same way that we like to perceive the sun as "rising" and "setting", when we know, scientifically, that it is just the world turning.

"There is always scope for changing your mind, this is the basis for consciousness, but it's not as big as we perceive it - that scope to change is limited based on the genetics we've been given," Critchlow says.

"Remember that our brains use 20 per cent of our daily energy quota to fuel this enormous circuit board, and to save energy your brain filters a lot of information, and makes assumptions, based on past experience.

"Judging people in the first few minutes that we meet them is all about saving energy.

Abandoning the idea of free will, and leaving everything to fate, can actually be quite relaxing. Picture: Shutterstock

"With friendship groups, or clans, people look for individuals with a similar outlook and who have similar genetics as well (unlike the way they look for sexual partners).

"You are drawn to people, friends, who are genetically similar to you, so you are more likely to see the world in the same way and have the same biases.

"You're saving energy because you don't have to explain things."

Speaking of biases, just think how reassuring it would be to discover that people who hold political views that strike you as unjustifiable were just born that way.

As Critchlow puts it, understanding that people believe in certain things, like religion or politics, because their brains were built that way, "might have massive consequences for reducing conflict at every level - as we discover more about the neurobiology of belief formation and prejudice, we might be able to boost our openness to new ideas".

She quotes the work of Jonas Kaplan, Professor of Psychology at USC's Brain and Creativity Institute, who has found that activity in the amygdala, and the size of people's anterior cingulate cortex, can be used to predict whether they are liberal or conservative.

His researchers were able to use brain scans to predict the political leanings of American test subjects - whether they voted Republican or Democrat - "with high sensitivity and accuracy".

"It's quite incredible and it does help me to understand people a little bit more, because those who are more liberal have a less-sensitive amygdala are more able to think about collaborations and partnerships for the future, rather than being scared in the moment," Critchlow says.

"Conservative types have a more reactive amygdala, and that gives them a heightened reactivity to fear. They assess risks and react conservatively.

"But the fact is, both types of people are really important for our survival as a species. If we were all one type it would be a disaster, we wouldn't have moved forward as a species."

This, of course, raises the interesting quote most often wrongly attributed to Winston Churchill: "if you're not a liberal when you're 25, you have no heart , if you're not a conservative by the time you're 35, you have no brain." Why would people's leanings change as they age?

"There's been some research at Oxford into that, following people from the 1960s to see whether they got more conservative as they got older, and it showed a 20-point increase in conservatism by the time they were 80 years old," Critchlow says.

"As you get older, you rely on more tried and tested routes within your mind, there is slightly less potential for plasticity, so you might become more risk averse.

"You also start to weigh how you process information differently; you place less weight on signals from the outside world, and more weight on the internal capacity of your mind - the information you have stored there.

"In a way, older people are not really listening to new ideas, because they take too much energy. They're relying on their own, refined information. Or what we think of as wisdom."

Kaplan, from USC, provides the quote in The Science of Fate that most neatly sums up the way most neuroscientists now see the world, which sounds radical to most people but is, Critchlow says, very much the accepted wisdom in her academic milieu.

"I don't believe in free will. The universe is deterministic,'' Kaplan says.

"We aren't the authors of our own actions, because everything is caused by something prior."

He is aware, however, that unlike scientists, many people would find this idea hard to live with, and adds: "Decisions are partially controlled by our emotional state, and most people find it depressing to believe that they have little or no free will, so there is a lot of value in believing in it."

Critchlow says abandoning the idea of free will can actually be quite relaxing. She says she frets less about the way she parents her young son, because she's not sure there's much point worrying about it.

"I tend to forget that most people don't think this way and I was chatting with my agent recently and she said 'So hang on, you really think we're really just like machines?' And I was like, 'oh yeah, that's what all of the people in my little bubble of neuroscientists think'," she says.

"But I think it's an idea that will become more accepted, and it's starting to happen.

"Don't forget that Darwin's theories were pretty radical there for a while."

Original post:
Why do opposites attract, and can we change our political leanings as we grow older? Neuroscience has the answers - The Canberra Times

Ever wake up in the middle of the night dripping in sweat, like you just ran a marathon? Then you're one of many people who have experienced night sweats, or sleep hyperhidrosis.

Night sweats aren't related to your environment, like if your room is too hot. Rather, they're usually caused by hormonal fluctuations in the body or are a side effect of medication.

Either way, they can have a big impact on your sleep. Night sweats often wake you up, and you may have to change your clothes or sheets in order to comfortably fall back asleep.

Here's what you need to know about the common causes of night sweats and when to see a doctor.

Night sweats are often linked to the hormonal fluctuations during menopause and perimenopause.

More than 80% of women in perimenopause and menopause experience hot flashes or sudden, intense feelings of warmth. When these happen at night, they can cause night sweats.

Menopause occurs 12 months after a woman has her last menstrual period, usually between the ages of 45 and 55. Perimenopause occurs in the 7 to 14 years before menopause.

Specifically, the drop in the hormone estrogen, which occurs during perimenopause, is linked to night sweats because it affects the body's temperature regulation.

"Women experience more night sweats related to hormonal changes during perimenopause and menopause," says Soma Mandal, MD, board-certified internist at Summit Medical Group, in Berkeley Heights, New Jersey.

Night sweats during menopause aren't cause for concern, but they can be uncomfortable.

If you're experiencing night sweats during menopause, talk to your doctors about treating the symptoms with medications that help replace estrogen.

Hormonal disorders can make it difficult for your body to regulate its normal temperature, which can cause night sweats.

Body temperature is regulated by the hypothalamus, an area in the brain that produces hormones. When your hormones are out of balance, it sometimes means that the hypothalamus isn't able to regulate temperature correctly.

Hormonal disorders that can affect body temperature and cause night sweats include:

If you experience other symptoms of a hormonal imbalance, such as weight changes or headaches, talk with your doctor about these symptoms.

If you're sick with a viral or bacterial infection, your body raises its internal temperature to fight off the infection, which is what causes fever.

This increase in body temperature can lead to sweating and night sweats are a common symptom associated with fevers.

"Various infections such as HIV, tuberculosis, and infectious mononucleosis can cause night sweats," Mandal says. "These conditions can produce chemicals called cytokines which combat infection. Cytokines can induce fever and night sweats."

If you experience a fever in addition to night sweats, you may want to check in with your doctor about what type of infection you have.

Certain medications can cause night sweats, including antidepressants for depression or anxiety.

A 2018 study found that up to 14% of people on Selective Serotonin Reuptake Inhibitors (SSRIs) the most common form of antidepressants experience excessive sweating and night sweats.

The study authors concluded that these medications likely affect the areas of the brain that produce hormones, which help control temperature and sweating.

Other medications that may cause night sweats include:

If your medications are causing night sweats, you can try sleeping in lighter clothes or keeping the room cooler. If night sweats continue to interrupt your sleep, you should talk to your doctor about your concerns.

According to Mandal, night sweats by themselves aren't always a cause for concern.

That's especially true if they're happening for a common reason like if you're going through menopause or taking SSRIs. However, if you're experiencing other symptoms as well, your night sweats could indicate a bigger problem.

"If they are accompanied by fever, weight loss, general malaise, or change in appetite, then it's time to get checked out by your primary care physician," Mandal says.

Read more:
4 common causes of night sweats and when to be concerned - Insider - INSIDER