Archive for October, 2019

Zacks Investment Research cut shares of Axovant Gene Therapies (NASDAQ:AXGT) from a buy rating to a hold rating in a research report sent to investors on Tuesday morning, Zacks.com reports.

According to Zacks, Axovant Sciences Ltd. is a biopharmaceutical company which focuses on the acquisition, development and commercialization of therapeutics for the treatment of neurodegenerative disorders. Its product candidate includes RVT-101 which is in different clinical trial for the treatment of Alzheimers disease and other forms of dementia. Axovant Sciences Ltd. is based in Hamilton, Bermuda.

A number of other equities research analysts also recently weighed in on AXGT. Svb Leerink assumed coverage on Axovant Gene Therapies in a research report on Friday, June 21st. They set an outperform rating and a $18.00 price target on the stock. Leerink Swann assumed coverage on Axovant Gene Therapies in a research report on Friday, June 21st. They set an outperform rating and a $5.79 price target on the stock. Cowen restated a hold rating on shares of Axovant Gene Therapies in a research report on Tuesday, July 9th. ValuEngine upgraded Axovant Gene Therapies from a sell rating to a hold rating in a research report on Thursday, August 1st. Finally, Robert W. Baird upgraded Axovant Gene Therapies from a neutral rating to an outperform rating and lowered their price target for the company from $16.00 to $13.00 in a research report on Monday, August 12th. Three research analysts have rated the stock with a hold rating and eight have issued a buy rating to the stock. The stock has a consensus rating of Buy and an average price target of $26.91.

Axovant Gene Therapies (NASDAQ:AXGT) last issued its quarterly earnings data on Friday, August 9th. The company reported ($1.23) earnings per share (EPS) for the quarter, topping the Zacks consensus estimate of ($1.34) by $0.11. Research analysts expect that Axovant Gene Therapies will post -4.25 EPS for the current year.

Several large investors have recently made changes to their positions in AXGT. Sphera Funds Management LTD. bought a new position in shares of Axovant Gene Therapies during the first quarter valued at about $6,794,000. BlackRock Inc. bought a new position in shares of Axovant Gene Therapies during the second quarter valued at about $1,482,000. Marshall Wace LLP bought a new position in shares of Axovant Gene Therapies during the first quarter valued at about $272,000. Jane Street Group LLC grew its stake in shares of Axovant Gene Therapies by 28.8% during the second quarter. Jane Street Group LLC now owns 46,455 shares of the companys stock valued at $289,000 after buying an additional 10,375 shares during the last quarter. Finally, Tower Research Capital LLC TRC grew its stake in shares of Axovant Gene Therapies by 955.3% during the second quarter. Tower Research Capital LLC TRC now owns 4,221 shares of the companys stock valued at $27,000 after buying an additional 3,821 shares during the last quarter. 13.48% of the stock is currently owned by hedge funds and other institutional investors.

About Axovant Gene Therapies

Axovant Gene Therapies Ltd., a clinical-stage gene therapy company, focuses on developing a pipeline of product candidates for debilitating neurological and neuromuscular diseases. The company's current pipeline of gene therapy candidates targets GM1 gangliosidosis, GM2 gangliosidosis, Parkinson's disease, oculopharyngeal muscular dystrophy, amyotrophic lateral sclerosis, and frontotemporal dementia.

Further Reading: Diversification Important in Investing

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Axovant Gene Therapies (NASDAQ:AXGT) Cut to Hold at Zacks Investment Research - Mitchell Messenger

Dr. Sharyn Lewin & The Lewin Fund Honor Breast Cancer Awareness Month with

Womens Health & Wellness Symposium at the Jewish Federation of Northern New Jersey

On Thursday, October 17th, Gynecologic Oncologist, Dr. Sharyn Lewin, on behalf ofThe Lewin Fund, hosted a Womens Health & Wellness Symposium at the Jewish Federation of Northern New Jersey in Paramus.

The three-hour event included presentations by top health and wellness experts for an interactive discussion about the latest in research, awareness and prevention of womens cancers, including what patients need to know to take charge of their health.

Experts presentations included: Sharyn M. Lewin, MD as the host and moderator, Debbie Besson, MS, RD, CSO, Shari Brooks, Dr. Dorothy Chae, L.Ac., Ph.D. and Shari Siegel-Goldman, MD.

Guests also had the option to partake in on-site genetic testing and flu shots.

The Lewin Fund hosts monthly educational events to help educate and raise awareness for traditionally underfunded gynecologic cancers that impact one in three women and their families. The Lewin Funds next event will be a free genetics symposium focusing on Updates in Hereditary Cancers & Genetics, on Sunday, October 27thfrom 1:00 PM 3:30 PM at the Holy Name Medical Centers Marian Hall (718 Teaneck Road, Teaneck, NJ). Guests can register atholyname.org/GeneticsSymposiumor by calling 201-833-3392.

AboutThe Lewin Fund

The Lewin Fund to Fight Womens Cancers is non-profit based in New York City that supports cutting-edge and comprehensive care for women with cancer.

The Lewin Fund is committed to sponsoring innovative womens cancer research and collaborating with womens cancer support programs to prevent cancer and extend life for women with cancer. The Lewin Fund is inspired by the vision of one courageous woman who battled gynecologic cancer and sought to push the frontiers of clinical research initiatives.

We are focused on: enhancing preventive and screening techniques to reduce the incidence of malignancies; funding cutting-edge, innovative research; supporting personalized medical strategies to treat cancer and decrease morbidity and mortality; and improving the quality of life during treatment and recovery by partnering with individuals on the front lines of cancer care.

Our founder, Sharyn Lewin, M.D., FACS, is a board-certified gynecologic oncologist, specializing in the diagnosis, treatment and management of ovarian, endometrial, uterine, cervical, vulvar and vaginal cancers. Her practice employs a comprehensive, multidisciplinary team approach to screening, treatment and overall improvement in quality of care for women at high risk for ovarian cancer and other gynecologic malignancies.

Dr. Lewin serves as medical director of the Regional Cancer Centers Gynecologic Oncology Division at Holy Name Medical Center and spearheads the development of a Womens Comprehensive Health Center, a female-focused initiative providing care and support for women of all generations.

To donate to The Lewin Fund, go toTheLewinFund.org/donate.

About Jewish Federation of Northern New Jersey

Jewish Federation of Northern New Jersey is dedicated to preserving, fostering and securing a vibrant Jewish community locally, in Israel and around the world. We provide the guidance, vision and resources necessary to help those in need. They work collaboratively with donors, volunteers and other Jewish organizations to ensure that your contributions will be distributed to achieve the maximum impact.

In todays hyper-connected, uncertain world where rapid response is critical Jewish Federation of Northern New Jersey has their fingers on the pulse of issues and are nimble enough to react to crises and respond to where the need is greatest. They are the eyes, ears and voice of your Jewish community.

http://www.jfnnj.org

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Dr. Sharyn Lewin & The Lewin Fund Honor Breast Cancer Awareness Month with Women's Health & Wellness Symposium at the Jewish Federation of...

Male and female mouse brains could have significant differences that reach right down to the cellular level, according to a new discovery.

Based on a reading of their genetic activity, neurons in a part of the mouse nervous system responsible for aggression and mating behaviours appear to be chemically structured in subtle but distinctly different ways between the two sexes.

These findings haven't been tested in other mammal species as yet, so we can't read too much into them. But it's a fascinating study that warrants further investigation in the brains of other animals.

Researchers from the California Institute of Technology and the Allen Institute for Brain Science in Seattle looked at a region of the brain called the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) in both male and female mice.

The VMHvl is tiny, made up of a mere 4,000 cells in mice, but still has quite a schedule on its hands, playing an important role in metabolism and complex sexual and social behaviours.

To identify cell types in the region, the researchers usedsingle cell RNA reading technology, which identifies genes that have been actively translated into RNA.

This is important, because while a species' full genome is kept in the nucleus of each cell, only a limited number of these genes will actually be expressed into proteins that meet the needs of the specific cell type. For example, a blood cell has different needs and therefore will activate different genes than a skin cell.

This technology provided the scientists with a snapshot of the 'books' being read in each cell's genetic library, giving them a clear idea of how each cell's individual physical make-up and activity differs.

Cells are considered to be of a certain type if clusters of genes in close proximity are expressed together to carry out a task.

In total the team identified 17 distinct types of brain cells in this tiny bit of brain tissue, which they then verified using glowing genetic tags in a process called fluoro in-situ hybridisation.

While that might sound like a lot of brain cell types, uncovering such a level of diversity shouldn't be all that surprising. Similar research has already identified scores of cell types across the entire hypothalamus.

What hadn't been seen before in mammals, at least were clear differences in neuron types between the male and female brains they analysed.

Some of these cell types were found in vastly greater numbers among mice of one gender or the other. One in particular was already known to make an enzyme that was present only in male mouse brains.

But another newly identified cell type was specific to female mice, not being found at all in male mice.

Importantly, these differences weren't a direct result of contrasting sex chromosomes, with the distinct brain cell types traced back to patterns of genes on parts of the genome both sexes possess.

Having genes that are generally active in one sex but not the other is hardly shocking. The small but significant leap in this case is finding clusters of activity large enough in brain cells to make them physically different types.

One thing that did come as a surprise was that only a few of these specific variations seemed to match specific behaviours, posing questions on just what it is many of these gender-biased cell types do.

"The results show that there are differences between male and female mammalian brains at the level of cellular composition as well as gene expression but that those differences are subtle, and their functional significance remains to be explained," says California Institute of Technology biologist, David Anderson.

It's a conclusion that's sure to polarise opinions on what is already a controversial topic. Research on the culture and biology of human gender is a divisive topic marked by a history of stereotypes and misinformation

On top of that, it's difficult to know how studies on lab animals might apply to humans. We're unlikely to be unique, but it's an assumption that would require further research to support.

Treading cautiously, studies like this one can't be dismissed out of hand either.

Like mice, there's a good chance our own brains not only promote different behaviours depending on whether we have a Y chromosome, but have fundamentally different cell types that just might be responsible for sex-specific functions.

That doesn't mean men are from Mars and women are from Venus. Genetics is complicated, and while we can generalise based on patterns, it doesn't dismiss the significance of individual variations or cultural influences.

Technology that can provide a detailed library list of genes being actively read in individual cells is changing what we know about everything from mental health to evolution to our own developing bodies.

We're almost certain to be surprised by just how diverse human biology can be.

This research was published in Cell.

See original here:
Gender-Specific Brain Cells Have Just Been Discovered Inside The Brains of Mice - ScienceAlert

Have you ever wondered why you wash your rice or soak it overnight before cooking it? Perhaps you wash your rice grains to enhance taste, reduce starch levels, or maybe that's just the way your family has always prepped rice. Thanks to a tip from science communicator Samantha Yammine who came across Dr. Nausheen Sadiq's neat finding while live-tweeting a forum on Diversity and Excellence in Science it turns out there is another reason why, as washing rice actually helps reduce the concentration of heavy metals, like chromium, cadmium, arsenic, and lead.

Heavy metal contamination in crops can be caused by human activities, such as mining, fertilizers, pesticides, and sewage sludge. Compared to most cereal crops though, rice (Oryza sativa L.) actually accumulates more heavy materials, like cadmium or arsenic, where long-term heavy metal intake can cause health risks. For example, long-term arsenic exposure leads to skin disease, high blood pressure, and neurological effects. This is especially important to consider as rice is a staple food across the globe.

Heavy metal contamination in crops can be caused by human activities, such as mining, fertilizers, pesticides, and sewage sludge.

Photo by TUAN ANH TRAN on Unsplash

In a recent study, researchers investigated the effects of different cooking methods (normal, high-pressure and microwave cooking) on the concentration, bio-accessibility and health risks posed by three heavy metals (cadmium, arsenic and lead) in two strains of brown rice. After cooking 100 grams of brown rice grains, researchers evaluated bioaccessibility (i.e. how much of the heavy metal is released for absorption) by mixing rice samples with simulated gastric fluid, and then used spectrometery to measure heavy metal concentration. Lastly, the researchers calculated the health risk posed by the heavy metals by calculating values such as the average daily dose.

Overall, the researchers found that instead of the three different cooking methods, it was the washing process which significantly reduced concentrations of cadmium, arsenic and lead, suggesting that the reduction may be due to rice morphology. For example, lead is found largely in the outer compartments of rice kernels, so lead is more likely to be removed during rice washing.

In contrast, the three cooking methods did impact bioaccessibility i.e. how much of the heavy metal would be released for absorption by the body. Here, washing and soaking isn't enough as rice absorbs water poorly at 25C. This finding was also reflected in calculated values: the average daily doses of cadmium, arsenic and lead were lower in washed and cooked rice, compared to raw rice.

It's worth noting that the European Commission has enforced limits on heavy metal levels - for example, arsenic is currently limited to 200 parts per billion (ppb) for adults and 100 ppb for infants. Both the U.S. and Canada currently have no limits in place for arsenic in food though Canada is currently reviewing a proposal to add maximum levels for arsenic found in white and brown rice, while the U.S. FDA has previously released a (non-binding) risk assessment, suggesting the same 100 ppb levels as Europe.

So the takeaway here is that yes, your family and all those professional chefs have been right all along. Yes, washing rice involves sacrificing some of its nutritional value, but doing so means you can reduce the levels of heavy metals present in grains, and still enjoy dishes like rice cakes. And returning back to Yammine's reporting, Saudiq actually shared that by soaking and washing rice for ~5 mins, you can get rid of 50-100% of these elements. (Thanks Sam!)

More here:
Genomics has a diversity problem. Here's how scientists are tackling it - Massive Science

This week Gina Rodriguez stepped into a proverbial pile of poo (once again) by casually sharing a video of herself singing the n-word. And seriously yall. Im tired.

Tuesday afternoon the Jane The Virgin actress posted a questionable clip on Instagram of her rapping Lauryn Hills verse on Ready or Not. Much to everyones chagrin, it shows her looking directly into the camera, as she says, fronting n*ggas give me heebie-jeebies.

Mind you, this is the same person who was dragged all up and down Al Gores internet this time last year for a series of All Lives Matter-esque micro-aggressions that didnt sit well with Black Twitter, and swore shed learned her lesson.

READ MORE: Habitual Hater Gina Rodriguez is the Latina friend you DONT want speaking up for you

So it should come as no surprise to anyone (except for maybe Gina herself) that this post would not go over well and would only open up a whole new can of worms. Which is exactly what it did.

To make matters worse, initially, rather than show any real remorse, she made one of those condescending, Im sorry if I offended apologies that are dripping with so much ego they only make things worse.

I am sorry if I offended anyone by singing along to The Fugees, to a song I love that I grew up on, she said in the post Im sure her publicist has since begged her to take down.

When she realized that her critics had an emotional I.Q. and werent going to accept a backhanded dismissal, then and only then did she stop patronizing us and actually apologize.

But just like in the case of Kevin Hart, when you talk down to people first, and have to literally get spanked by the public before taking real accountability, its impossible to unring that bell and it also makes us wonder if you even really believe what you did was wrong.

Wednesday, Rodriguez updated her Instagram with a message in which she admits that she thoughtlessly sang along and that whatever consequences I face for my actions today, none will be more hurtful than the personal remorse I feel.

The word I sang carries with it a legacy of hurt and pain that I cannot even imagine, she further concedes. Then concluded that this is a much deserved lesson I have some serious learning and growing to do and I am so deeply sorry for the pain I have caused.

While I appreciate this rare moment of introspection, I cant help remembering back in January when Rodriguez appeared on the Sway in the Morning radio show. During that softball interview she took zero accountability for falling out of favor with the public and then tearfully explained that we all just misunderstood her.

She even went as far as to describe her father as dark-skinned, despite the fact that hes barely the complexion of undercooked toast.

Then, for the rest of the segment, she basically repeated over and over again how shes fundamentally a good person, how Black actresses reached out to her to agree that the backlash was silly, and how if she in any way triggered our frayed sensibilities, she was sorry. But still, we all got it wrong. Sorry though.

OPINION: Gina Rodriguez STILL doesnt get why were mad, cries over anti-Black accusations

So basically, what were seeing here is a pattern where:

1. Gina Rodriguez shows a racial blind spot, which is understandable because society is designed to ingrain those in us.

2. Black Twitter tells her to cut that s**t out.

3. She gives a backhanded apology that makes it sound like she thinks were all really just too dumb to understand shes above reproach simply because shes a good person who grew up around Black people. Oh and yeah shes Latina so that should count for something cause everyone knows theres no racism in Latin America, right?

4. When all else fails, cry. Extra points if you cry to a Black man who is taught to find you sympathetic. Triple points if you also manage to mention how your Black female friends forgave you, cause apparently they get to speak on behalf of the rest of us.

Got it. The Rodriguez Apology Tour itinerary is pretty clear at this point.

Whats sad is, it took something as egregious as the flippin N-WORD to get her to even stop long enough to consider that maybe just maybe shes actually be part of the problem.

So are we just gonna keep writing pieces pitting Black women against Latina women? my fellow Afro-Latina colleague asked me bluntly one day. Because who does that really serve?

She said this at the top of the year, in response to finding out that I was going to be penning an op-ed about Rodriguezs emotional appearance on Sway in the Morning.

And you know what? That inquiry hit me between the eyes because Ive written countless articles about the Oppression Olympics and how many of our spaces are both Black and Brown, therefore making it against our own best interests to constantly fight amongst each other while white supremacy is left off the hook.

I also have a deep personal aversion to having my sharp intellect used as a tool to bring down other women. Because trust and believe, as a writer there have been several times when potential employers have tried to finesse me into using my pen as a sword, as if I was some sort of literary goon or hitman commissioned to torpedo someones career.

Ive worked really hard to side-step all of these traps and so on that day 9 months ago, instead of going for the jugular in my piece I showed Rodriguez some grace. I gave her the benefit of the doubt. I also prayed all those Black actress friends she keeps mentioning encouraged her to spend less time shedding white woman tears and more time learning about her glaring blindspots.

For those who are asking: Wait, are you implying that Gina Rodriguez is a white woman? let me make this clear for the umpteenth time. Race is as much about optics as it is about genetics and culture.

You can pull out your Ancestry.com results and be as ethnic and proud about being 9% Black as you want. But the fact remains that your VISUAL proximity to whiteness be you fair, racially ambiguous, or a white presenting Latina will afford you privileges that it would be intellectually dishonest not to acknowledge.

So much in the same way when a white woman weaponizes her tears it usually brings society (even judges in high profile murder trials) to their knees, thanks to centuries of race based conditioning, when Rodriguez was in that Sway interview sobbing about how much we hurt her feelings in January many of those same white women tears dynamics were at play when the host, the audience, and even I all found ourselves feeling a little guilty for how much pain wed caused her.

She was dead ass wrong and yet somehow were the ones who felt bad, simply because she cried. Sound familiar?

READ MORE: Gina Rodriguez tearfully breaks down on Sway in the Morning

As a result of that coddling (which I now regret), sis got so comfortable around us again, she felt empowered to post a video of her saying the n-word. In 2019. During the Trump administration. Despite having a Netflix password and therefore access to dozens of documentaries that essentially explain, So, yeah. Lets not ever do that Gina.

So what have I learned from all this as not just a journalist but also as a critically thinking Black woman in America?

Welp! The next time I lovingly put my foot on someones neck and ask them to be accountable, as long as Im being fair and factual, Im not gonna let yall gaslight me into pulling punches.

I love uplifting women, I love uplifting my community and I still take no pleasure in ever dragging anyone (especially when the facts alone can do that). But stroking peoples egos to the point where theyre allowed to constantly play victim serves no one.

Rodriguez is probably a really lovely person, in fact Im almost convinced she is. But she apparently has a lot of maturing to do before she can even ever confidently stand on that soap box she keeps reaching for. Until she stops playing victim and really owns how she has consistently contributed to this ongoing PR nightmare, this probably wont be her last time issuing an apology to us. Tears and all.

Follow writer Blue Telusma on Instagram at @bluecentric

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I TRIED to forgive Gina Rodriguez but her white woman tears are wearing me out - TheGrio

For women all over the world,acneis a skin concern that's likely reared its head on several occasions throughout life. From breakouts in our teen years to surprising smatterings in adulthood, we can hardly remember a time when we weren't reaching for products to help nip zitsfast.

Treating acne can be frustrating and complicated, so we turned toone of thebest dermatologists in Los Angeles, Nancy Samolitis, MD, co-founder and medical director ofFacile, to help break down the root causes, andthe best treatmentapproach. First and foremost, she'll cover the leadingacne-causing culpritsto help us better understand what we're up against. Then, continue on to check out Samolitis's expertly curatedskincare routinefor banishing breakouts, once and for all.

Despite our best efforts to care for our skin, sometimes acne and its contributors are just written into our genetic code. "The biggest contributor to acne is genetics," Samolitis says. "Some people are just programmed to have larger pores, more oil production, inflammatory skin, etc." That's not great news, but genetic or not, there are always solutions to help manage skin concerns like acne.

Hormones help to regulate everything from reproduction to stress, and according to Samolitis, they can also have quite a bit to do with acne. "Hormonal stimulation of oil production is also an important factor. This is obviously a factor in teens, where their hormones are just starting to rise, but is also very common in adult womenoften for unknown reasons," she explains. "Certain hormonal medications such as the progesterone component of birth control pills, IUDs, and bioidentical hormone supplements can trigger acne."

It's no surprise that what we put into our bodies has an effect on our skin. After all, just about every fad diet out there claims to be a road to clearer skin. Samolitis believes that there are specific foods to watch out for while actively treating acne, "in particular, foods that spike insulin levels like sugary or processed foods, " she says. "The hormones in meat and dairy that are given to farm animals may also play a significant role in acne, but this is poorly understood."

"Finally, use (or lack thereof) of certain skincare products can trigger breakouts as well."With the ever-growing selection of products available now, we have to be more cautious than ever when trying new things, as to not upset the skin's delicate pH balance. "This day and age, there are not as many comedogenic (pore-clogging) products and makeup as there used to be, but products that contain thick creams or ointments may lead to clogged pores and worsening of acne," says Samolitis.

With so many different factors that could potentially be contributing to acne, it might feel like an impossible feat to figure out the best steps to take. And the truth is, there's no better place to start than by consulting a trusted physician to nail down a treatment plan."If you have acne that is severe, cystic, scarring, and is resistant to skincare and treatments, it's important to seek treatment by a board-certified dermatologist who can assess and work up the acne, ruling out underlying medical causes," Samolitis implores. "There are many prescription treatments that are safe when used under proper supervision and can treat severe acne before scarring occurs."

In the meantime, our trusty expert has mocked up a skincare routine that will help anyonewho would like to treat their acne.

La Roche-Posay Effaclar Deep Cleansing Foaming Cream ($23)

Samolitis recommends starting the day with a clean slate by using a cleanser with salicylic acid. "Exfoliating acids, in particular, oil-busting salicylic acid, help to remove excess oil that is leading to clogged pores in the first place," she says.

Versed Just Breathe Clarifying Serum ($20)

After the skin is freshly cleansed, it's the perfect time to go in witha highly active ingredientbased serum. This one by Versed uses willow bark extractand a powerful zinc blend to clear out excess pore-clogging sebum.

PCA Skin Clearskin ($45)

"Niacinamide is a more newly recognized anti-inflammatory ingredient that works particularly well for adult female acne and also has anti-aging benefits as a bonus," Samolitis explains. She carries this niacinamide and antioxidant-rich treatment in her own practice andrecommends it to clients struggling with a multitude of inflammatory skin conditions.

Versed Dew Point Moisturizing Gel-Cream ($15)

As mentioned above, Samolitis cautionsagainstoil-based, heavy creams for those dealing with acne. The pore-clogging that could ensue just isn't worth the risk. That's why this lightweight, gel-cream moisturizer is the perfect alternative for achieving deep hydration without running the risk of breakouts.

EltaMD UV Clear Facial Sunscreen Broad-Spectrum SPF 46 ($35)

And of course, any daytime regimen should include SPF. Samolitis calls this popular choice from EltaMD acne-friendly sunblock and points out that it also contains niacinamide as an added bonus.

Versed Wash It Out Gel Cleanser ($13)

In the evenings, Samolitis again recommends cleansing to keep the skin free and clear of acne-causing dirt and debris. Rose, mint, and apple amino acids make this one a super-gentle option that doesn't sacrifice efficacy.

Differin Adapalene Gel 0.1% Acne Treatment ($13)

"Vitamin A derivatives (like retinol and adapalene, the active ingredient in over-the-counter Differin gel) help to normalize skin cell turnover and keep skin cells from sticking in the pores. They can also stimulate healthy collagen growth, improving acne scars," Samolitis advises.

Versed Hydration Station Booster With HA ($20)

Samolitis emphasizes how important it is toreplenish moisture in the skin to fight any possible redness or dryness thatmight arise while using a retinoid treatment. This Versed booster deploys two different kinds ofhydrolyzed hyaluronic acid into the skin.

Neutrogena Hydro Boost Hyaluronic Acid Hydrating Face Moisturizer Gel-Cream ($17)

"I love a light hyaluronic acidbased moisturizing cream like Neutrogena Hydro Boost," Samolitis says.

Neutrogena Rapid Clear Benzoyl Peroxide Leave-on Acne Face Mask ($8)

"When all is dry and soaked in, use benzoyl peroxide as needed.Naturally antibacterial, benzoyl peroxide detoxifies the bacterial overgrowth that occurs in inflammatory acne," Samolitissays. She recommends this leave-on mask by Neutrogena.

Malin + Goetz Acne Treatment Nighttime ($22)

As a final step, Samolitis also swears by a sulfur spot treatment as needed for any especially aggressive bumps. She likes this one by Malin+ Goetz.

Up next, everything you need to know to shrink a pimple overnight (really).

This article originally appeared on Who What Wear

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A Top Dermatologist Says This Is the Best Skincare Regimen to Treat Acne - Yahoo Lifestyle

18 October 2019

Tania Adib discusses premature menopause with Female First

The menopause is a natural part of ageing for women, which occurs when their oestrogen levels start to decline, causing their periods stop and their ovaries to lose their reproductive function. The average age for a woman to start the menopause in the UK is 51 however, due to a range of different factors, some women can experience it before they reach the age of 40 often referred to as premature menopause.

Here, Ms Tania Adib, Consultant Gynaecologist at The Lister Hospital, part of HCA Healthcare UK, explains 7 things that everyone should know about premature menopause.

Ms Tania Adib says: The symptoms of early menopause are often the same as those experienced by women undergoing menopause at a normal age. At first, symptoms may include irregular or missed periods, periods that are lighter or heavier than usual and hot flushes. These symptoms usually signal that that the ovaries are producing less oestrogen.

"Further to this, some women may also experience the following symptoms, which will coincide with the menstrual changes mentioned above:

Ms Tania Adib says: There are several known causes of early menopause, although for some women the cause cannot be 100% determined:

"In addition to the above factors, any medical treatments that damage the ovaries or stop oestrogen production can cause early menopause. (For example, chemotherapy for cancer)."

Ms Tania Adib says: Like all menopausal women, those experiencing premature menopause will experience lowered oestrogen levels. Low levels of oestrogen can lead to lots of changes in a womans overall health and may increase her risk for certain medical conditions, such as heart disease, osteoporosis, cognitive decline, colon cancer, gum disease, tooth loss, and cataract formation.

"Women experiencing premature menopause are encouraged to visit their GP if ever they experience any unusual symptoms that might be associated with the above, just so that they can receive a thorough examination and rule these out.

Ms Tania Adib says: Unfortunately there is not a cure for premature menopause however, treatment options are available to help women to manage some of the unpleasant symptoms or conditions that come with it.

"The most common treatment is hormone replacement therapy (HRT), as this can treat menopausal symptoms.

Ms Tania Adib says: With the help of IVF, and other modern assisted fertility treatments, it is still possible to conceive a baby after the menopause.

"For example, many young, healthy women are now choosing to freeze their eggs as precautionary measure. She can then undergo IVF or IUI when she is older, if she struggles to fall pregnant naturally or cant because she has reached menopause. If a woman knows that her mother or grandmother experienced premature menopause, they I would advise that she considers egg freezing as this can help to protect her fertility for the future.

"For women who are experiencing premature menopause, but havent frozen their eggs, there are other assisted fertility options for them to explore such as egg donation or embryo adoption.

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World Menopause Day: Five things you need to know about premature menopause - FemaleFirst.co.uk

Ive always admired multi-sport post-secondary student-athletes who can organize and adhere to demanding timetables, who excel in a two-pronged pursuit of higher education and championship trophies. Admittedly, this comes from someone whod be hard-pressed to get a one-float parade up and running. Still, its not hard to marvel at the exploits of Sophie de Goede, a two-sport star at Queens University.

The Victoria, B.C., native is a member of two varsity womens teams: basketball and rugby. She plays the former very well, the latter exceedingly well, while maintaining a lofty 3.9 grade point average in the third year of a challenging commerce program. She is first and foremost, as is any successful student/jock(ette) who competes on more than one varsity playground, a master of time management. Ask her and she will tell you that it is an essential attribute on the road to success in both disciplines. Time management skills, as the saying goes, are old hat for her, and they were long before she ever pulled on a tricolour jersey.

Im used to it, de Goede says nonchalantly, momentarily interrupting a Sunday study session to take a phone call from a newspaper hack. The two-time Academic All-Canadian is pleasant, polite, cheerful, simply flat-out nice all of which belies her well-earned reputation as a rugged, tenacious, fearless force on the pitch, so fit as to be practically inexhaustible. Wonderfully skilled, she is arguably the best rugby player in university today. She speaks of long-ingrained habits and a structured regimen that she began practising, in earnest, in high school, with hectic schedules routinely peppered with class times and plenty of practice/game times. Her high school sports included you get winded just reading the list rowing, soccer, field hockey, swimming, volleyball, basketball, cross-country, track and field and, of course, rugby. That excludes the rep roundball and Rugby Canada age-group clubs she played on and sometimes captained. (She was already a nationally carded rugby sevens athlete while in high school.)

My parents made sure I played other sports, de Goede recalls, and because I played other sports, its made me a better, more well-rounded rugby player. But my parents never pushed me towards rugby.

They didnt have to.

She was sold on the game practically by the time she was out of pull-ups. De Goede remembers scampering on the sidelines as a toddler while her dad coached a Victoria rugby club team, and just as often being on another sideline near her mom, who guided the same clubs womens side. Such front-row raw exposure to the sport at an early age was one reason why rugby took hold, osmosis-like.

The other reason was genetics. Sophie is a chip of the old block make that two old blocks the latest link in a regal rugby lineage. Her father, Dutch-born Hans de Goede, was a hard-nosed, no-nonsense lock forward who captained Canada in the first World Cup (1987). Her mom, Stephanie White, a Calgary native, was the inaugural captain of a Canadian womens side. Their distinguished playing and coaching careers were cited during eachs respective induction into the Rugby Canada Hall of Fame. Its an enviable ancestry, the equine equivalent of having Northern Dancer and Seabiscuit as your ma and pa. Youre born to run, baby, or in the case of the contact-craving de Goede, run around, over or through.

Team Canada senior womens coach Sondro Fiorino calls de Goede an exceptional, extremely gifted player. He coached her this summer when she joined the senior womens 15s for a Super Series tournament in San Diego.

Youve heard of the five-tool player in baseball? Fiorino asks before finishing his point. In rugby, its a four-tool player and Sophie possesses all four tools: speed, skills, size and smarts. Shes strong, agile, athletic, fast and intelligent. And she kicks for points. Not many forwards do that.

For good measure, he adds: Shes the fittest player in Canada, hands down. Her fitness scores are through the roof.

That glowing assessment doesnt surprise Mikela Lehan, an ex-Gaels rugby teammate who now manages the Gaels team. Lehan recounts a story from de Goedes very first day at training camp. Wed heard about this good first-year player coming from B.C., but you know, you never know what that persons going to be like, Lehan says. Sophie shows up just as were about to run our 1,600 metres, then she goes out and laps just about everyone.

As for de Goede the person, Lehan lauds. She is the most well-rounded person I know. She excels in every part of her life: friends, family, school, sports, socially. Sophies in her own category.

Ditto in university womens rugby. De Goede came to Queens asRugby Canadas reigning female player of the year after having spent the previous campaign training with the national sevens side. In her Golden Gaels debut, she tallied two tries and three converts, later copping OUA rookie-of-the-year laurels.

Her sophomore season brought OUA and U Sports player-of-the-year kudos, and this year de Goede, six feet and a solid 180 pounds, has upped her game and repeated as OUA top player.

Sophs a generational player, states her Queens coach, Dan Valley, who moonlights as an assistant with the Canadian senior womens club. Shes humble and helpful, a collection, really, of every positive sports cliche out there, an absolutely incredible talent and ultimate team player.

On the hardwood, de Goede isnt exactly taking up space.

In her freshman year, she played nearly 20 minutes a game and averaged seven rebounds and a hair under 10 points per outing. Despite missing half of her second season due to an injury sustained at the 2018 rugby nationals, she still finished second on the Gaels in rebounds.

Shes already a solid, dependable player, womens basketball coach James Bambury notes on his heady, agile charge, and we expect she will take a giant leap this season because of the commitment she made to the team this summer. He alludes to a month of training that de Goede put in with her hoops mates prior to leaving for the rugby Super Series, then an additional month after she returned.

Shes so versatile, the coach adds. Were comfortable using her at any position, one through five. She can run, shoot, pass, defend, rebound and has phenomenal vision on the floor.

Because the two sports overlap slightly, Bambury says de Goede, 20, will not play in any basketball games until the rugby campaign is over. With the (rugby) national championship on the table, we wont interfere. An exception was made for the recent McGill/Queens exhibition game commemorating the 100th anniversary of the first university womens basketball tilt between the same two schools. Citing its historical significance, de Goede asked to play, then went out and drained a team-high 20 points in her 20 minutes of floor time.

The pursuit of higher education is proceeding well. Now its time to chase down a national title. The unbeaten Gaels rugby unit, with its two-sport linchpin leading the way, competes in the eight-team U Sports womens rugby championship tournament, Oct. 30 to Nov. 3, in Ottawa.

Patrick Kennedy is a retired Whig-Standard reporter. He can be reached at pjckennedy35@gmail.com

See the article here:
Two-sport star shines for Queen's Gaels, national rugby teams - The Kingston Whig-Standard

What is Cryonics?

Cryonics is the low-temperature freezing (usually at 196 C or 320.8 F or 77.1 K) and storage of a human corpse or severed head, with the speculative hope that resurrection may be possible in the future. Cryonics is regarded with skepticism within the mainstream scientific community. It is a pseudoscience, and its practice has been characterized as quackery.

Cryopreservation technology is used for the preservation of living cells and tissues at very low temperature.

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Cryonics technology adopted by medical sector to preserve living body organs which can boost the demand of this technology. Government investment in medical sector and increasing deaths caused by incurable diseases are the major driving factor for this industry.

In 2018, the global Cryonics Technology market size was xx million US$ and it is expected to reach xx million US$ by the end of 2025, with a CAGR of xx% during 2019-2025.

This report focuses on the global Cryonics Technology status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Cryonics Technology development in United States, Europe and China.

The key players covered in this study. Praxair. Cellulis. Cryologics. Cryotherm. KrioRus. VWR. Thermo Fisher Scientific. Custom Biogenic Systems. Oregon Cryonics. Alcor Life Extension Foundation. Osiris Cryonics. Sigma-Aldrich. Southern Cryonics

Market segment by Type, the product can be split intoSlow freezingVitrificationUltra-rapid

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Table of Contents

1 Report Overview1.1 Study Scope1.2 Key Market Segments1.3 Players Covered1.4 Market Analysis by Type1.5 Market by Application1.6 Study Objectives1.7 Years Considered

2 Global Growth Trends2.1 Cryonics Technology Market Size2.2 Cryonics Technology Growth Trends by Regions2.3 Industry Trends

3 Market Share by Key Players3.1 Cryonics Technology Market Size by Manufacturers3.2 Cryonics Technology Key Players Head office and Area Served3.3 Key Players Cryonics Technology Product/Solution/Service3.4 Date of Enter into Cryonics Technology Market3.5 Mergers & Acquisitions, Expansion Plans

The study objectives of this report are:. To analyze global Cryonics Technology status, future forecast, growth opportunity, key market and key players.. To present the Cryonics Technology development in United States, Europe and China.. To strategically profile the key players and comprehensively analyze their development plan and strategies.. To define, describe and forecast the market by product type, market and key regions.

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Cryonics Technology Market Present Scenario and the Growth Prospects with Forecast 2025 - Midnight Stocks

Cryonics Technology market report examines the short-and medium-term economic and profitability outlook for Cryonics Technology industry.. The Cryonics Technology market is expected to grow at a CAGR of over XX% during the period 20192024.

The global Cryonics Technology market has been subjected to several regulatory compliances and crucial coding terminology over the years. Adherence to regulatory standards remains crucial for vendors.

The study considers the present scenario of the Cryonics Technology market and its market dynamics for the period 20192024. It covers a detailed overview of several market growth enablers, restraints, and trends. The report covers both the demand and supply aspect of the market. This research report on the Cryonics Technology market covers sizing and forecast, market share, industry trends, growth drivers, and vendor analysis.

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The competitive environment in the Cryonics Technology market is intensifying. The market currently witnesses the presence of several major as well as other prominent vendors, contributing toward the market growth. However, the market is observing an influx of local vendors entering the market.

The study profiles and examines leading companies and other prominent companies operating in the Cryonics Technology industry.

List of key players profiled in the report:

Alcor Life Extension FoundationBiocisionCellulisCesca TherapeuticsCryologicsCryonics Asia Ltd.Cryonics InstituteCryothermGE HealthcareHumaiKriorusOregon CryonicsOsirisPanasonic BiomedicalPraxair TechnologySigma-AldrichSouthern CryonicsThermo Fisher ScientificVWR

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TheCryonics TechnologyMarket Segmentation:

Product Product Type Segmentation SegmentationSlow FreezingVitrificationUltra-Rapid

Industry SegmentationAnimal HusbandryFishery ScienceMedical SciencePreservation Of Microbiology CultureConserving Plant Biodiversity

End User SegmentationLife Science And Healthcare FacilitiesResearch Laboratorie

Vendors can consider targeting key regions such as APAC, North America, and Europe to gather maximum customer attention. Countries in the APAC region such as China, India, and Japan among others are expected to display significant growth prospects in the future due to high economic growth forecasts along with huge population statistics leading to high consumption of goods and products.

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Cryonics Technology Market segmentation by region:

The changing regulatory compliance scenario and the growing purchasing power among consumers are likely to promise well for the North America market. New product development and technological advancements remain key for competitors to capitalize upon in the Cryonics Technology industry across the globe.

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Key Market Insights:

The report provides the following insights into the Cryonics Technology market for the forecast period 20192024.

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Cryonics Technology Market with Future Prospects, Key Player SWOT Analysis and Forecast To 2024 - Exponent Online

Male menopause? The first thing that you wonder when you hear this term is can a man experience menopause? Well, if research studies are to be believed, women are not the only ones who go through hormonal changes during old age. Even men experience low levels of hormones as they age. However, in some men, this decline may lead to low testosterone. This is the reason why many experts prefer to call the condition andropause or late-onset hypogonadism (LOH) or androgen deficiency in aging male (ADAM) instead of male menopause.What is andropause?Andropause is derived from Greek words in which Andras means human male and pause means cessation. Hence, andropause is defined as a condition which causes a decrease in sexual satisfaction or a decline in the generalized feeling of well-being due to testosterone deficiency.

What causes andropause?In every man, the level of testosterone hormone tends to decline after the age of 25 and continues to decrease gradually till the rest of the life. The hormone levels decline at a rate of one percent per year with age.

The production of testosterone decreases as a function of age, however, this decrease is not universal. Moreover, the rate of decline in hormonal levels is different in different individuals. In most men, the gradual decline of the hormonal levels doesnt seem to have any effect on their sexual performance. However, in some, it can lead to a drastic fall in sex drive or libido. The rate of decline is affected by chronic health problems such as obesity, illness, emotional stress, medication and poor lifestyles.

At what age does andropause begin?Andropause can occur between 40-60 years of age. Sometimes, younger men may also experience andropause symptoms due to certain health issues.

What happens during andropause?One of the reasons for a decline in the testosterone level with age is due to a reduction in the mass of Leydig cells present in the testicles. These cells play a key role in the production of androgen (testosterone) when stimulated by the luteinizing hormone (LH). It could also be due to a dysfunction in the pituitary and hypothalamic equilibrium that control the secretion of LH. This lead to abnormally low levels of LH, which in turn causes low testosterone production. Testosterone deficiency can affect the psychological, sexual, emotional, and physical well being.

Here are the common signs and symptoms of male menopauseLow sex drive: Testosterone plays an important role in maintaining your sex drive and function. Hence, low levels of this hormone can lead to loss of libido. Moreover, in the long run, it can also cause difficulty in achieving an erection, increasing the risk of erectile dysfunction. The diagnosis of late-onset hypogonadism is based on the symptoms associated with sexual health such as loss of libido, morning penile erection, and erectile dysfunction.

Depression: Studies have shown that depression can be associated with low concentrations of testosterone in older men. This is because testosterone helps to regulate mood.

Fatigue: It is one of the common symptoms of andropause which may occur due to low levels of testosterone or hypotestosteronemia. Testosterone is needed by the body to maintain energy levels and lack of energy leads to fatigue.

Abdominal obesity: Aging in men is associated with fat deposition in the central and upper body. This could be due to the decline in the concentration of growth hormones with age. These hormones also play a key role in the maintaining the levels of the sex hormonebinding globulin (SHBG) and testosterone. Hence, a decline in the growth hormones increases SHBG levels and causes testosterone deficiency with age.

As testosterone slows down the buildup of fat in the abdominal region, the deficiency of the hormone causes accumulation of belly fat.

Low bone density: A significant reduction in the testosterone levels in young men can accelerate bone loss and osteoporosis. In older men, normal levels of testosterone are needed to maintain bone mineral density, especially at the spine and hip region. Hence, low levels of testosterone in older men can increase the risk of hip fracture due to low bone mineral density.

Insomnia: Testosterone also helps to regulate sleep patterns. If the testosterone level reduces, it can lead to disturbed sleep and insomnia. And with age, this can further cause irritability, daytime sleepiness, and difficulty in staying asleep.

In addition to these symptoms, testosterone deficiency can lead to impaired cognitive function, reduced muscle mass and strength, and increased risk of cardiovascular complications.

How is andropause treated?If the symtptoms of andropause are not affecting your day to day life and can be alleviated by adopting a healthy lifestyle with a nutritious diet, exercise, and proper sleep, then you may not require any treatment.

However, if you are experiencing any severe symptoms, then you must discuss the same with your doctor.

Studies have reported that testosterone replacement therapy (TRT) can help improve symptoms such as fatigue, decreased libido, and depression. The other benefits of TRT include:

-Improved body composition and muscle strength

-Improved bone mineral density

-Improved cognitive function

References:

1. Nandy PR, Singh DV, Madhusoodanan P, Sandhu AS. Male Andropause : A Myth or reality. Med J Armed Forces India. 2008 Jul;64(3):244-9.

2. Singh P. Andropause: Current concepts. Indian J Endocrinol Metab. 2013 Dec;17(Suppl 3):S621-9.

3. Gould DC, Petty R. The male menopause: does it exist?: for: some men need investigation and testosterone treatment. West J Med. 2000 Aug;173(2):76-8.

Read the rest here:
Andropause or male menopause: Causes and symptoms - Times of India

WHEN Cassie Hylans gave birth to baby Freddie-Philip it was extra special.

Not just because it was the first time she had met her son, but because she knew he wouldn't live much longer.

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But nothing could have prepared the 27-year-old and her partner Steven Hale, 25, for that heartbreaking moment.

Cassie, from Burton upon Trent, Staffordshire, told DerbyshireLive: "As he took his last breath my partner dropped to his knees and screamed.

"It was the hardest thing you could ever go through.

"It was so surreal just watching it happen and not being able to do anything to help keep him alive."

The couple discovered at their 20-week scan that Cassie has a genetic condition called Kallmann Syndrome there was a 50 per cent chance it would be passed onto her baby.

It meant that he had no fluid around him and his kidneys were covered in cysts.

Cassie, a cleaner, said she was given some options - all of which she refused - and decided to continue with the pregnancy.

She said:"We knew he wouldnt survive but at the end of the day he was still my baby and I was growing him. I wanted to see his face and give him a cuddle. He was ours."

We knew he wouldnt survive but at the end of the day he was still my baby and I was growing him

Freddie-Philip was born breathing on November 29, 2016, and the family were able to spend "four hours of unexpected precious time" with him.

Cassie said:"I gave birth on the normal labour ward and we took tonnes of pictures, had cuddles with him and the vicar came and gave him a blessing. We still talk to her to this day.

"The nurses were amazing and gave us two teddies and a keepsake memory box with his hand and footprints in. It was really special."

The family were supported by staff at the Snowdrop Suite, a special unit for bereaved parents at Burton's Queen's Hospital.

Cassie said: "My mum and partner were there with me the whole way through and I cant remember that much because it was all a blur.

"We could spend as much time with him as we wanted the nurses left us to it and we were at the end of the labour ward so we didnt have to see new mums walking around with their babies."

The pair were able to keep Freddie-Philip with them in a special cuddle cot, but when the time came to return home, the new parents were devastated.

What is Kallmann syndrome?

Kallmann syndrome is a rare geneitc condition, characterised by delayed or absent puberty and an impaired sense of smell.

It is a form ofhypogonadotropic hypogonadism, which is a condition resulting from a lack of production of certain hormones that direct sexual development.

Males often have an unusually small penis and undescended testes and most don't develop secondary sex characteristics at puberty - such as the growth of facial hair, deeping of the voice.

In females the start of monthly periods and breast development is usually delayed or doesn't happen at all.

Without treatment, most affected men and women are unable to have biological children.

Kallmann syndrome can have a wide variety of additional signs and symptoms including a failure of one kidney to develop, abnormalities of bones in the fingers or toes, a cleft lip or palate, abnormal eye movements, hearing loss, and abnormalities of tooth development.

Some affected individuals have a feature called bimanual synkinesis, in which the movements of one hand are mirrored by the other hand.

It's more common in males than females.

Source: Genetic Home Reference

Cassie said: "It was so hard to go home.

"Everything was normal and his bedroom was fully kitted out waiting for him.

"Going there without him in our arms was heartbreaking and it was like our world had stopped."

Cassie said the tragedy did not put the couple off having another child and when they got pregnant with Bobby, who is now aged 23 months, they were "so happy."

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She said: "The pregnancy was fine, but he only has one kidney.

"I was overwhelmed when Bobby was born.

"I felt heartbroken that he would never get to meet his big brother and he was the spitting image of Freddie-Philip.

"November will always be a very bittersweet month for me as Bobby was born at the start and Freddie was born at the end."

Cassie is full of praise for the midwives who cared for her following Freddie-Philip's death and said they were still welcome to access support at the Snowdrop Suite.

She said: "That time was so precious and without the staff at the hospital and the specialist suite we would not have been able to make such special memories.

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"Baby loss awareness is so important and it should not be a taboo subject. I would rather people talk about it then ignore that it happened.

"Freddie-Philip was still here. He is still a person. He is my son."

The couple have shared their story to mark Baby Loss Awareness Week, which ends today.

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We screamed as our baby boy took his last breath at four hours old after I gave birth knowing hed die - The Sun

SYDNEY, Australia, Oct. 18, 2019 (GLOBE NEWSWIRE) -- Noxopharm (ASX: NOX) announces that it will apply its glutamate-inhibition technology to the treatment of glioblastoma multiforme (GBM).

GBM remains a poorly managed cancer, with surgery, radiotherapy and the chemotherapy drug, temozolomide, the current standard of care, offering median survival of only 12-15 months.

Recent research now has confirmed that brain chemical, glutamate, is playing a key role in driving the aggressive nature of GBM growth.1,2

Glutamate is an important brain chemical, triggering passage of electrical impulses between brain cells. These chemicals are known as neurotransmitters. Glutamate is the brains main neurotransmitter, with important roles in learning and memory.

GBM cancer cells now have been shown to be connected to brain cells (neurons) that are feeding glutamate into the tumour, driving growth of the cancer cells.1

As a result of a collaboration with UNSW Sydney in 2016, Noxopharm already has drugs in its chemical library that are selective glutamate-inhibitors. This proprietary intellectual property centred on a search for a drug capable of protecting the brain from glutamate-associated brain damage following a stroke or severe concussion.

Noxopharm already has a number of potential lead candidates, which puts it well-placed to expedite the path to the clinic.

Dr Graham Kelly, Noxopharm Executive Chairman, said, This is an exciting opportunity that we believe we lead the world on. Its early stage with many questions yet to be answered, but if we are successful, then we see this approach as potentially having the same benefit as blocking the way sex hormones drive the growth of breast cancer and prostate cancer. If anti-hormone therapy can deliver very significant survival benefits with highly aggressive forms of breast cancer and prostate cancer, then we see no reason why blocking glutamate function cannot deliver the same benefit for patients with GBM.

A key challenge will be to limit a glutamate-blocking effect just to the tumour. A drug that blocks glutamate function in the brain generally would be far too toxic. Our compounds appear to work specifically where there is glutamate over-dose and have been well tolerated in animals to date. This is what we believe gives us a major competitive edge in what seems likely to be a major new area of drug development.

The Companys primary focus remains on Veyondaand bringing it through the clinic and to market for the treatment of late-stage prostate cancer using its DARRT and LuPIN treatment regimens. The glutamate-inhibition program becomes the Companys second pipeline drug program but will be secondary to the Veyondaprogram.

References:1. Venkataramani V et al (2019) Nature 573, 532-538.2. Ye ZC, Sontheimer H. (1999) Cancer Res 59, 4383-4391.

About GBMGlioblastoma multiforme (GBM) is the most common and most aggressive of the primary brain tumors. Patients with GBM present with symptoms such as headache and seizure often late in the disease when the tumour has become well-established and inoperable. As a result, the median survival is very short at about 12 months.

About GlutamateGlutamate (glutamic acid) is a neurotransmitter that brain cells use to pass signals, including electrical impulses, between cells. It is important in learning and memory and is the dominant neurotransmitter in the brain and spinal cord. Glutamate works by increasing the entry of ions such as calcium into receiving nerve cells. Excessive amounts of glutamate lead to toxic amounts of calcium entering the cell, resulting in over-stimulation and death of healthy brain cells in a process known as excitotoxicity.

About NoxopharmNoxopharm is a clinical-stage Australian drug development company with offices in Sydney and New York. The Company has a primary focus on the development of Veyondaand is the major shareholder in Nyrada Inc, a spin-off company developing a pipeline of non-oncology drugs.

http://www.noxopharm.com

Forward Looking StatementsThis announcement may contain forward-looking statements. You can identify these statements by the fact they use words such as aim, anticipate, assume, believe, continue, could, estimate, expect, intend, may, plan, predict, project, plan, should, target, will or would or the negative of such terms or other similar expressions. Forward-looking statements are based on estimates, projections and assumptions made by Noxopharm about circumstances and events that have not yet taken place. Although Noxopharm believes the forward-looking statements to be reasonable, they are not certain. Forward-looking statements involve known and unknown risks, uncertainties and other factors that are in some cases beyond the Companys control that could cause the actual results, performance or achievements to differ materially from those expressed or implied by the forward-looking statement. No representation, warranty or assurance (express or implied) is given or made by Noxopharm that the forward-looking statements contained in this announcement are accurate and undue reliance should not be placed upon such statements.

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Potential for Fundamental Change in the Treatment of Brain Cancer - BioSpace

TEXAS, October 17, 2019 (LifeSiteNews) A pediatric endocrinologist who specializes in transgenderism and medical transitions took the stand yesterday in the case of James Younger, theseven-year-old whose mother wants to transition him to a girl. His father, Jeffrey Younger, is trying to stop his ex-wife from doing this.

James mother is Anne Georgulas, a pediatrician.

Dr. Daniel Schumer, the endocrinologist, explained the process of a medical transition, which begins with puberty blockers and eventually can lead to cross-sex hormone therapy. He said that a child who has reached puberty should be given puberty blockers if his or her bodys natural development would cause significant distress.

The point of puberty blockers is to delay the decision making around things that like [gender identity] until the child is older, he said.

Dr. Schumer clarified that starting puberty blockers does not necessarily lead to cross-sex hormone therapy. Dr. Schumer stated that puberty blockers are meant to buy time for children to develop their understanding of gender and develop increased maturity before making the decision to take hormones to make them more like the opposite sex.

When questioned by Mr. Odeneal, Mr. Youngers attorney, and the amicus attorney about the side effects of these drugs, Dr. Schumer claimed they are no different than the normal side effects of puberty for the sex of the desired gender.

Risks with estrogen [are] similar to risks of a female going through puberty.The majority of effects of testosterone or estrogen are similar to puberty.

According to the Mayo Clinic, the side effects of feminizing hormone therapy include:

Dr. Schumer denied that cross-sex hormone therapy leads to any significant side effects. There is a host of evidence that suggests otherwise, and a growing community of people who have de-transitioned back to their real sex.

Follow all LifeSiteNews coverage of the James Younger casehere.

More here:
Expert witness in trial of 7-year-olds transition downplays dangers of cross-sex hormone therapy - Lifesite

Mighty Night uses clean, clinically proven ingredients in effective dosages that work while you sleep resulting in a fresh complexion each morning. The proprietary formula boosts overnight renewal by supporting skin cell turnover, scavenging free radicals, promoting optimal sleep and improving skin texture.

During sleep, the body produces more collagen and melatonin both known to reduce fine lines and wrinkles. Levels of the stress hormone cortisol fall during sleep, which helps skin to repair daytime damage. And, the human growth hormone, responsible for accelerating skin's repair and cell regeneration, is released during sleep.

Mighty Night ingredients include Ubiquinol, the most absorbable form of CoQ10 which protects the skin cell's membrane and supports overall renewal; Ceramides to lock in moisture and boost elasticity; Ferulic Acid proven to scavenge free radicals; and, a clinically studied combination of Valerian Root, Hops and Passion Flower that helps to promote optimal sleep.

"Sleep is when your skin repairs itself, grows new cells and fortifies against moisture loss and free radical damage. Valerian Root and Hops are two herbs I recommend for better sleep quality, which is critical for overnight recovery," says Dr. Breus PHD, aka The Sleep Doctor.

Dermatologist Dr. Julie Russak of the Russak Dermatology Clinic in New York says: "Ferulic acid and ceramides offer skin benefits while you sleep by improving the protective barrier of skin and strengthening it. When our skin barrier is at its optimal state, we appear healthier. HUM's Mighty Night is a responsibly sourced, multi-beneficial supplement I trust and recommend to my patients."

Mighty Night is available at http://www.humnutrition.com and http://www.sephora.com beginning October 18th. It retails for $40 for a 30-day supply (60 capsules) and is vegan, vegetarian, Non-GMO, gluten-free and sustainably sourced.

Take 2 at bedtime and expect results in 4 to 6 weeks. Here's to a peaceful beauty rest, Sleeping Beauty.

Press Contact:Shauna Aminzadehshauna@humnutrition.com

About HUM NutritionHUM Nutrition, the leading beauty supplement company, revolutionized an entire industry by successfully merging beauty and wellness. By completing the beauty routine from within, HUM initiated a movement that has inspired over half a million people to lead healthier lifestyles and retailers to create a new category. HUM has reinvented every touch point of the vitamin experience starting with a proprietary online quiz that pairs consumers with curated product recommendations and a personal Registered Dietitian. HUM's innovative range addresses ultra-specific beauty concerns. Every formulation is rooted in clinical research, and ingredients are carefully sourced and triple tested by independent labs for quality and purity. HUM's appealing brand resonates like no other with today's consumers and its distinct color-coded packaging and friendly tone has successfully removed the often-intimidating barrier to vitamins and supplements. For more information, visit HumNutrition.com and follow @HumNutrition.

SOURCE HUM Nutrition

http://www.humnutrition.com

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HUM Nutrition Launches Mighty Night, the first skin cell renewal supplement specifically formulated to optimize beauty sleep from within. - PRNewswire

You may want to sort out your chronic pain, look and feel younger, or maybe you would like to increase your energy level so you can pursue your goals.

Well, thankfully the team at Richardson Pain & Wellness is ready and able to help you do it, their doctors have many years of experience with custom-made wellness plans suited to each patients individual needs and wants, ensuring that they not only feel renewed in our office but for many years to come. All you have to do is set up an appointment with one of the doctors, and they will help you get started and create a plan to suit your needs and interests.

The pain clinic Richardson offers testosterone replacement therapy and hormone replacement therapy at Richardson. If tests show that you do have low T and you notice the condition taking over your life, then you should consider hormone replacement therapy in Richardson to supplement the bodys production of testosterone to levels of young adulthood.

Furthermore, replacement therapy may lead to desired results, such as greater muscle mass and a stronger sex drive.However, Richardson Pain & Wellness the testosterone therapy to treat low T is vital is surprised to make you aware. Due to the mental and physical risks may develop with self-administered artificial or synthetic testosterone.The testosterone therapy Richardson is suitable for those with low testosterone, call Richardson Pain & Wellness today to schedule a consultation.

Also, Richardson offers the residents of medical weight loss programs Richardson, which they designed with care and precision to suit each patient. So, what does the weight loss program entail? Well, they create a customized diet, exercise plan, and supplement program, they believe it is essential to focus on workingwith their body for weight loss, not against it.

Richardson Pain & Wellness creates a weight loss program that is put together by two doctors alongside a registered dietitian. These professionals have years of experience in the field of wellness and pain management. For instance, Janel Kobza-Chukhman has over 15 years of nutrition counseling experience. A considerable advantage of Richardson Pain & Wellness is that they provide you with all three elements; a diet plan, an exercise plan, and supplements. Whats even better is the result you achieve after all the hard work of keeping to your specified program.

Richardson believes the key to healthy weight loss is following a plan that is specially made for you, and they are proud of the weight-loss programs they provide for their clients.

Contact the Richardson pain clinic today if you would like to book an appointment and have one of their experienced doctors custom make a wellness plan to suit your needs or if you want to start your weight-loss journey today. Ring the clinic on (972) 907-1125, or you can email alignrightchiropractic@gmail.com to schedule an appointment.

Source:https://thenewsfront.com/richardson-pain-wellness-offering-testosterone-replacement-therapy-male-hormone-replacement-therapy-medically-assisted-weight-loss-and-conservative-pain-management-in-richardson-texas/

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Richardson Pain & Wellness Offering Testosterone Replacement Therapy, Male Hormone Replacement Therapy, Medically Assisted Weight Loss, and...

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There has been little advancement in the treatment of men's sexual dysfunction, or "E.D.," since the early 90's when the "little blue pill" made it's way onto the scene. Andrew Rinehart with Wasatch Medical Clinic says that finally, there is a new treatment that isn't simply a Band-Aid for erectile dysfunction; it eliminates the problem at its root.

"Acoustic Wave Therapy treats the root cause of the problem, which is blood flow," Rinehart said. "It widens blood vessels, increasing the amount of blood released into the penis during arousal."

It does this, he says, without the harmful side effects that medication and hormone therapy can have. It targets the problem without throwing your whole body off balance.

Andrew said that if viewers call now, a free doctor exam and ultrasound (worth $300+) will be done with a medical doctor. So there really isn't anything to lose! Even if you don't go through with the treatment, you will know the cause of your E.D. But with the results patients are seeing - such as a total rebound in the bedroom in 3-4 weeks, who wouldn't want to give this a try?

For your free consultation, call 801-901-8000 or visit wasatchmedicalclinic.com.

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With this new technology, men have been able to ditch the little blue pill quickly, and for good - KSTU FOX 13 Salt Lake City

A vaginal yeast infection also called vaginal candidiasis occurs when the yeast fungus (candida) that is naturally present in the vaginas microbiome (the collection of good bacteria, fungi, and other microbes that help keep the vagina self-cleaning and healthy) proliferate beyond normal amounts. The imbalance can cause discomfort and pain it may also itch down there but its not typically considered a serious health risk. Still, heres what you need to know to live your life through the irritation and soreness.

The fungus Candida albicans is behind most yeast infections. Its a naturally occurring microbe in the vaginal microbiome that can proliferate out of control when other microbes diminish. (That said, other types of yeast can cause yeast infections, too, but its rarer.)

Certain activities can aid this imbalance. Douching, contrary to popular belief, is an entirely unnecessary, unhygienic practice that actually disrupts the balance of the vaginas microbiome, makes the vagina less healthy, and puts individuals at risk of a vaginal infection. Excess use of antibiotics for instance, taking antibiotics for a cold or the flu (for which antibiotics are ineffective) can kill off the kinds of vaginal bacteria that hold yeast microbes in check and contribute to a yeast infection. Hormone fluctuations as associated with pregnancy, hormonal birth control use, and/or hormone therapy can also affect the balance of the vaginas microbiome and cause a vaginal yeast infection.

The bottom line is this: Yeast infections arent caused by being dirty. Theyre caused by a host of factors, many entirely natural and many outside the control of the person experiencing one.

Three in four women will get a yeast infection at some point in their lives; many of them will experience at least two. Pregnant women are particularly prone to yeast infections, for the same reason they are more prone to urinary tract infections: their hormonal fluctuations can alter the balance of the vaginas microbiome. For the same reason, women who use hormonal birth control may also be at higher risk for yeast infections.

That said, anyone with a vagina is able to contract a vaginal yeast infection. And anyone, period, is able to contract a yeast infection in other parts of the body. (For instance, a yeast infection of the mouth is known as thrush, and yeast infection is a major cause of diaper rash in babies.)

A yeast infection is not considered a sexually transmitted infection, because people with vaginas can also develop a yeast infection by other means than sex. That said, according to the Mayo Clinic, some research suggests that sexual intercourse both oral and vaginal can affect ones risk of yeast infection. Still, it isnt quite clear to scientists whether having oral or vaginal sex when you have a yeast infection makes your partner more likely to get a yeast infection as well, according to Planned Parenthood.

Either way, experts are quite clear: Its best to avoid vaginal and/or oral sexual activity until the yeast infection has cleared up partly because theyre not 100% sure if the infection transfers to a partner, partly because the friction of sex can irritate the vaginal tissue further and worsen the infection, and partly because some oil-based yeast infection treatments could cause condoms to break, raising the risk of pregnancy.

Related on The Swaddle:

Why Women Are More Prone to Urinary Tract Infections Than Men

According to Planned Parenthood and the Mayo Clinic, typical yeast infection symptoms include some or all of the following:

Yeast infections are common before and/or after periods for the same reason pregnant women and women who use hormonal contraceptives are more prone to developing yeast infections: hormonal fluctuations. The waxing and waning of hormones around the time of menstruation can also alter the balance in the vaginas microbiome and put someone at risk of a yeast infection.

Nothing. Yeast infections are treatable during menstruation. Also, its totally fine to use tampons or pads if youre bleeding and also have a yeast infection, Dr. Jennifer Conti, a clinical assistant professor at Stanford University in obstetrics and gynecology, told Womens Health in 2017. However, (a) make sure they are not scented, or deodorizing, tampons and/or pads, which could contribute to an imbalanced vaginal microbiome, and (b) anyone menstruating and experiencing a yeast infection at the same time might want to be more conscious about frequently changing tampons or pads.

For anyone who has never had a yeast infection before, it is a good idea to consult a doctor to confirm the diagnosis before attempting to treat a yeast infection at home. Also, pregnant women, women who have diabetes, women who have a weakened immune system, and women who have had four or more yeast infections in the last year should consult a doctor for treatment automatically.

However, for anyone else who is familiar with yeast infections and recognizes the signs, many over-the-counter treatments are available.

According to the Mayo Clinic, anti-fungal medication for yeast infection can come in a variety of forms: creams, ointments, oral pills, and vaginal suppositories. Regimen differs according to each medication, and treatment can last anywhere from one day to a week. Oral pills are not recommended for pregnant women.

For severe yeast infections, or lingering symptoms, a doctor might prescribe a longer course of anti-fungal therapy, a multi-dose therapy (two or more different kinds of anti-fungal medications), or, as a last recourse, a boric acid vaginal suppository, if the infection proves resistant to other forms of treatment.

Home remedies for yeast infection are popular; a quick Google search will provide lists upon lists of at-home, DIY yeast infection treatments, with dahi (yogurt) topping recommendations. While some of these jugaad remedies have tentative or inconsistent scientific support for their curative effects, none have been tested remotely enough to be considered actual treatments. Experts are clear: Do not attempt an at-home, DIY remedy for a vaginal yeast infection without consulting a doctor first.

Yes, certain measures can minimize ones risk of a vaginal yeast infection, per the Mayo Clinic. Avoiding douching tops the list of preventative actions. And avoiding scented feminine products, including pads and tampons, is also a good step for the same reason; the scent additives can disturb the balance of vaginal microbes.

Also, avoiding unnecessary antibiotics can prevent the kinds of vaginal bacteria that hold yeast microbes in check from dying off.

Finally, avoiding lingering in damp clothes, especially damp clothes made of synthetic material such as swimsuits, workout clothes, pantyhose, and synthetic underwear can do much to minimize the chances of a yeast infection. Note that its the breathability of the fabric that is as important as the dryness; for instance, using talcum or other powders might avoid vaginal dampness, but its definitely not a good idea for vaginal health.

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Why Does It Itch 'Down There'? It May Be a Vaginal Yeast Infection - The Swaddle

TEXAS, October 17, 2019 (LifeSiteNews) A number of expert witnesses and healthcare workers testified in court yesterday about transgenderism and James Younger, the seven-year-old whose mother, Anne Georgulas, wants to transition him into a girl against his fathers wishes.

Dr. Benjamin Albritton continued his testimony, followed by Diane Zilca of Dallas County Family Services; Rebekka Ouer, James counselor from Dallas Rainbow Therapy; Dr. Abel Tomatis, James trauma therapist; Jasmine Jackson, a Child Protective Services investigator; and finally, Dr. Daniel Schumer, a pediatric endocrinologist from the University of Michigan.

There were many highlights from the testimonies, and there were a few common veins throughout them. Most of the expert witnesses spoke about the fluidity of James gender presentation, and the positive long-term impact of James identifying with his biological sex.

Mr. Odeneal, the attorney for James dad Jeffrey Younger, and the amicus attorney focused on the discussion of the criteria for a gender dysphoria diagnosis and the definition of gender itself. Each professional who commented on gender gave a slightly nuanced answer and all of them prefaced their statements with, I think gender is

Gender is in the brain...It's not that you want to be [a gender], its that you are, Ms. Ouer told the court.

Gender is more socially constructed, Dr. Tomatis said. It is someones innate sense of oneself as masculine or feminine.

Gender is an internal sense of oneself as a boy or girl, man or woman, or any gender in between....its a social construct, Dr. Schumer insisted. Everyone is born without a gender identity.

Gender is the focus of the case as Georgulas a pediatrician is working to convince the court that she deserves to be named Sole Managing Conservator for James and his twin, Jude. Jeffery Younger, meanwhile, is fighting to prevent Georgulas from making independent decisions for the boys, such as starting a medical gender transition for James.

In addition to defining gender, Youngers attorney and the amicus attorney the court-appointed lawyer who is supposed to be neutral and act in the best interest of the children focused on James diagnosis of gender dysphoria and the imminent threat of a medical transition.

In his questioning of Dr. Albritton, Dr. Tomatis, and Dr. Schumer, Youngers attorney drew their attention to the fact that James does not meet a critical aspect of the criteria required for gender dysphoria: James isnt distressed. Dr. Albritton also testified that the boys are not afraid of their father. Other witnesses testified to the contrary, but Dr. Albritton has spent the most time with the boys and the family of all the expert witnesses.

Albritton noted in his psychological evaluation, which was reviewed during his testimony: Neither child appears to be depressed, anxious or aggressive ...He [James] gave no indications of other significant psychological difficulties.

Dr. Tomatis testified that he saw no clinical symptoms of distress in his interactions with James.

Ms. Ouer stated that the lack of distress exhibited by James is due to the fact that he is affirmed as a girl with his mother and at school.

Mr. Odeneal also highlighted medical records from James pediatrician referring James to a medical transition clinic when he reaches age eight or nine: Will plan to have a psychological evaluation at GENECIS when closer to 8-9 years old to consider hormone suppression.

Dr. Schumer, who specializes in medical transitions, testified that puberty blockers should not be started until a child hits Tanner Stage 2 of puberty. He also told the court that the average start of puberty in someone who is a male is eleven and a half.

Mr. Odeneal also showed the jury a referral letter from Ms. Ouer to Childrens Medical Hospital for the GENECIS clinic. The GENECIS clinic completes gender evaluations and facilitates medical transitions, which involve giving children puberty blockers and in many cases cross-sex hormones.

This is a letter of recommendation that my client, James Younger, aka Luna, begin the process of becoming a patient of the GENECIS clinic so that she [sic] can receive a full psychological assessment for gender dysphoria and potentially take hormone blockers.

The expert witnesses, all of whom were paid by Georgulas to testify, and the state agency representatives admitted that James does not identify with only one gender.

Dr. Albritton told the court, There is still some fluidity in his [James] thinking.

Ms. Zilca, from Dallas County Family Services, refused to call James by anything other than Luna. She told the court, She [James] does not identify with only one gender.

James counselor Ms. Ouer who specializes in working with the LGBT community told the court that gender fluidity means something different for each person. She also stated that James may not be transgender despite her having diagnosed him with gender dysphoria since there is some fluidity in his expression.

Ms. Ouer and many of the other experts insisted on the importance of calling James Luna and letting the seven-year-old guide any changes.

While questioning Ms. Ouer, the amicus attorney shared that James initially came to his mom asking to be called Starfire, a female character in Teen Titans Go! Ms. Ouer chuckled slightly.The amicus attorney asked why allowing James to go by Starfire didnt align with Ms. Ouers recommendation of letting children control their gender transition. Ms. Ouer stated that affirming the childs underlying gender desires is what is most important.

Dr. Tomatis, James so-called trauma counselor, also testified. Georgulas attorneys referred to Dr. Tomatis as James trauma counselor, but he said he neither specializes in trauma, nor has he diagnosed James with trauma. He noted that he is seeing James to help with emotional regulation in the midst of such difficult circumstances.

Dr. Schumer, a pediatric endocrinologist specializing in gender transitioning, was flown in from Michigan to testify. In his testimony, he said that children begin developing the concept of gender between six and seven years old, but later also stated it occursbetween five and seven years old. James first reported to his father that his mother told him he was a girl when he was just three years old.

At one point during Dr. Schumers testimony, Georgulas attorneys shared Dr. Schumers formal custody recommendation with the court. Dr. Schumer has never met either of the boys or their parents. Judge Kim Cooks chastised the lawyers privately and announced to the court that only Dr. Albritton is qualified to make custody recommendations.

Each of the expert witnesses admitted that returning to identifying as being a boy would be the easiest path forward for James.

Certainly it offers less challenges for him, Dr. Albritton stated.

Being trans is not an easy path, Ms. Ouer testified.

There was much back and forth regarding gender, sex, prounouns, and whether James should be called James or Luna.

The case resumed today with Mr. Youngers testimony.

Follow all LifeSiteNews coverage of the James Younger case here.

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Pro-LGBT adults admit 7-year-old in gender transition case isnt totally convinced hes a girl - Lifesite

For those who want to match their physical gender with what they feel is their true gender, Thailand is the place for Sex Reassignment Surgery (SRS) also known as Gender Reassignment Surgery, Sex Change Operation, and MtF Surgery, to name a few. So, what makes Thailand such an attractive destination for this type of procedure? In short, its because patients can get the most out of such surgeries in Thailand thanks to the number of highly trained surgeons, low-cost and quality health care, and decades of knowledge and experience in perfecting this procedure.

If youre considering SRS in Thailand, or you have a family member, a partner, or a friend who is wondering what is involved in the procedure, this guide should help to paint a clearer picture.

To undergo SRS is a huge, life-changing decision that should not be made lightly. It is a lengthy process that requires a lot of resilience and patience. Before the actual surgery, you will first need to live as a woman for at least a year and undertake hormone treatment to help reshape your body contour and stimulate the growth of a labia majora.

Heres a list of the required prerequisites that all surgeons will insist upon before considering your case:

The actual process usually involves a few procedures:

You may also choose other surgical procedures, such as a Tracheal Shave to remove your Adams apple, or a Buttock Augmentation to increase the volume of the buttocks. Since every patient is unique, the procedures involved in SRS can be performed based on your needs and budget.

The most important part of male-to-female surgery is the creation of the vagina. There are numerous surgical techniques to do this based on your preference. You can discuss with your surgeon which one is best for you. The other popular techniques are as follows:

1. SRS without vaginal depth

2. SRS with Penile Skin Inversion

3. SRS with Scrotal Skin Graft

4. SRS with Sigmoid Colon by Laparoscopic Technique

Caitlyn Jenner, Possibly the Most Famous Transgender Person Ever

Recovery after surgery will be a long and painful process. It will also require several follow up procedures as well as constant monitoring so you will have to stay a little bit longer at the hospital until you are fully ready to be discharged. Generally, allow for a minimum of 3 weeks stay in Thailand or the country of your choice area after your surgery. Most people are able to return to work in about 4-6 weeks after a sex change operation. Furthermore, you can resume strenuous work and exercise in about 6-8 weeks. It is vital that you strictly follow all medication instructions during your recovery period.

Social support is very important before and after the surgery, especially the support that comes from your family and loved ones. You have to be socially and emotionally stable before you undergo the operation. This is why it is required that you have proper counseling to help you with your emotional wellbeing. You have to prepare yourself mentally, before, during and after transition because it can be quite overwhelming and stressful.

It is also important that you maintain regular check-ups with your local Doctor to monitor the progress of your healing and avoid such complications.

The success rate for a sex change is very high, given our technological advancements. Gender reassignment surgery from male to female has a higher success rate than female to male; this is why more male transgender opts for a sex change.

However, given the nature and complexities of this type of surgery, you also have to be aware of its complications:

Possible side effects may also include:

SRS can be very expensive, especially since it is difficult to get this type of surgery in many countries. One reason why Thailand is popular with those who want to change their sexual identity is that the country offers more affordable fees. Many patients come from the United States because the US has the most expensive male-to-female SRS prices in the world.

The prices range from $25,000 to $30,000 for just the reconstruction of the genitals alone. If you want to add breast augmentation and voice feminisation surgery, you can expect to pay more than $50,000. Additionally, some clinics in the US dont include consultation fees in their prices, so you need to pay at least $50-100 for every consultation.

In general, SRS in Thailand costs around a third to half of what it can cost in the United States. For the reconstruction of the genitals in Thailand, you can expect to pay between $8,400 to $13,700 depending on which technique you choose.

Breast augmentation costs approximately $4,100 to $6,170 and Voice Feminisation Surgery costs between $3,590 to $7,180. In total, you will need to pay around $16,090 to $27,050 in Thailand for the complete procedure. These prices can also include packages, such as hospitalization accommodation, post-operative care, consultation fee, post-operative care, medications, and transportation.

The low-cost healthcare in Thailand does not mean low-quality treatment. In fact, Thailand is extremely popular among medical tourists because the country is known to have high-quality healthcare. Numerous medical centers in Thailand are accredited by prestigious international organizations, such as the Joint Commission International (JCI). The country has come a long way since its first Sex Reassignment Surgery in 1975, with many surgeons specialising in SRS for years, some even have over 20 years of experience. With their skills and experience, the surgeons and clinics can give patients the proper care they need and guarantee the best possible result.

Since there are many medical centres in the country that offer Male to Female SRS, it is understandable that some will better than others. To avoid disappointment, do your research, read reviews, find out about the clinics accreditation, and ask for your surgeons certifications. Better still, seek out the services of a dedicated Medical Tourism Facilitator like MyMediTravel who will guide you through the whole process and find you the best possible surgeon/clinic/hospital available and within your budget.

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Your ultimate guide to Sex Reassignment Surgery in Thailand (male to female) - The Thaiger

As biologys first big science collaboration, the international Human Genome Project mapped and sequenced the entire human genome, paving the way for unparalleled innovations in medicine, biotech and life sciences.

More than 8 million people can now trace their origins to this scientific breakthrough, which began with a single in vitro fertilization (IVF) birth four decades ago. By 2100, IVF could be responsible for 3.5 percent of the global population.

This relatively simple gene-editing technique carries world-changing implications: By allowing scientists to precisely change an organisms DNA on the spot, CRISPR could eradicate inherited diseases or cure existing ones. Since its inception in 2012, CRISPR has fueled much controversy too, as teams look to modify everything from crops to mosquitos. That discussion reached a fever pitch this year after a scientist in China claimed to have created the worlds first babies genetically edited with CRISPR.

Identifying individuals based on hair, blood or other biological samples may seem a given now. But its only possible because of this breakthrough sciencewhich also has led to new findings in cancer and genetic conditions.

Read full, original post: Biotech Top Ten

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Top 10 biotech innovations of all time, including CRISPR, IVF babies - Genetic Literacy Project

Humankind is on the verge of a genetic revolution that holds great promise and potential. It will change the ways food is grown, medicine is produced, animals are altered and will give rise to new ways of producing plastics, biofuels and chemicals.

Many object to the genetic revolution, insisting we should not be playing God by tinkering with the building blocks of life; we should leave the genie in the bottle. This is the view held by many opponents of GMO foods. But few transformative scientific advances are widely embraced at first. Once a discovery has been made and its impact widely felt it is impossible to stop despite the pleas of doubters and critics concerned about potential unintended consequences. Otherwise, science would not have experienced great leaps throughout historyand we would still be living a primitive existence.

[Editors note: This is the first in a four-part series examining genetic engineerings impact on our lives. The second installment examines regulatory obstacles blunting the potential of genetically engineered animals;the third looks at the role of gene editing in medicine; and the final segment looks at synthetic biology and other novel applications.]

Gene editing of humans and plantsa revolutionary technique developed just a few years ago that makes genetic tinkering dramatically easier, safer and less expensivehas begun to accelerate this revolution. University of California-Berkeley biochemistJennifer Doudna, one of the co-inventors of the CRISPR technique:

Within the next few years, this new biotechnology will give us higher-yielding crops, healthier livestock, and more nutritious foods. Within a few decades, we might well have genetically engineered pigs that can serve as human organ donorswe are on the cusp of a new era in the history of life on earthan age in which humans exercise an unprecedented level of control over the genetic composition of the species that co-inhabit our planet. It wont be long before CRISPR allows us to bend nature to our will in the way that humans have dreamed of since prehistory.

The four articles in this series will examine the dramatic changes that gene editing and other forms of genetic engineering will usher in.

Despite the best efforts of opponents, GE crops have become so embedded and pervasive in the food systemseven in Europe which has bans in place on growing GMOs in most countriesthat it is impossible to dislodge them without doing serious damage to the agricultural sector and boosting food costs for consumers.

Even countries which ban the growing of GMOs or who have such strict labeling laws that few foods with GE ingredients are sold in supermarkets are huge consumers of GE products.

Europe is one of the largest importers of GMO feed in the world. Most of the meat we consume from cattle, sheep, goats, chickens, turkeys, pigs and fish farms are fed genetically modified corn, soybeans and alfalfa.

And the overwhelming majority of cheeses are made with an enzyme produced by GM microbes and some beers and wines are made with genetically engineered yeast.

North America, much of South America and Australia are major consumers of foods grown from GE seeds. Much of the corn oil, cotton seed oil, soybean oil and canola oil used for frying and cooking, and in salad dressings and mayonnaise is genetically modified. GM soybeans are used to make tofu, miso, soybean meal, soy ice cream, soy flour and soy milk. GM corn is processed into corn starch and corn syrup and is used to make whiskey. Much of our sugar is derived from GM sugar beets and GE sugarcane is on the horizon. Over 90 percent of the papaya grown in Hawaii has been genetically modified to make it resistant to the ringspot virus. Some of the squash eaten in the US is made from GM disease-resistant seeds and developing countries are field testing GM disease-resistant cassava.

Many critics of GE in agriculture focus on the fact that by volume most crops are used in commodity food manufacturing, specifically corn and soybeans. One reason for that is the high cost of getting new traits approved. Indeed, research continues on commodity crops, although many of the scientists work for academia and independent research institutes.

For example, in November 2016, researchers in the UK were granted the authority to begin trials of a genetically engineered wheat that has the potential to increase yields by 40 percent. The wheat, altered to produce a higher level of an enzyme critical for turning sunlight and carbon dioxide into plant fuel, was developed in part by Christine Raines, the Head of the School of Biological Sciences at the University of Essex.

A new generation of foods are now on the horizon, some as the result of new breeding techniques (NBTs), such as gene editing. Many of these foods will be nutritionally fortified, which will be critical to boosting the health of many of the poorest people in developing nations and increase yields.

Golden rice is a prime example of such a nutrition-enhanced crop. It is genetically engineered to have high levels of beta carotene, a precursor of Vitamin A. This is particularly important as many people in developing countries suffer from Vitamin A deficiency which leads to blindness and even death. Bangladesh is expected to begin cultivation of golden rice in 2018. The Philippines may also be close to growing it.

A strain of golden rice that includes not only high levels of beta carotene but also high levels of zinc and iron could be commercialized within 5 years. Our results demonstrate that it is possible to combine several essential micronutrients iron, zinc and beta carotene in a single rice plant for healthy nutrition, said Navreet Bhullar, senior scientist at ETH Zurich, which developed the rice.

The Science in the News group at Harvard University discussed some of the next generation foods.

Looking beyond Golden Rice, there are a large number of biofortified staple crops in development. Many of these crops are designed to supply other micronutrients, notably vitamin E in corn, canola and soybeansProtein content is also a key focus; protein-energy malnutrition affects 25% of children because many staple crops have low levels ofessential amino acids. Essential amino acids are building blocks of proteins and must be taken in through the diet or supplements. So far, corn, canola, and soybeans have been engineered to contain higher amounts of the essential amino acid lysine. Crops like corn, potatoes and sugar beets have also been modified to contain more dietary fiber, a component with multiple positive health benefits.

Other vitamin-enhanced crops have been developed though they have yet to be commercialized. Australian scientists created a GE Vitamin A enriched banana, scientists in Kenya developed GE Vitamin A enhanced sorghum and plant scientists in Switzerland developed a GE Vitamin B6 enhanced cassava plant.

Scientists genetically engineered canola, a type of rapeseed, to produce additional omega-3 fatty acids. Research is being conducted on developing GM gluten free wheat and vegetables with higher levels of Vitamin E to fight heart disease.

Other more consumer-focused genetically-engineered crops that do not use transgenics, and have sailed through the approval system include:

Other products are in development that fight viruses and disease. Scientists have used genetic engineering to develop disease-resistant rice. A new plum variety resists the plum pox virus. It has not yet been commercialized. GE solutions may be the only answer to save the orange industry from citrus greening, which is devastating orange groves in Florida. GE might be utilized to curb the damage caused by stem rust fungus in wheat and diseases effecting the coffee crop.

In Africa, GE solutions could be used to combat the ravages of banana wilt and cassava brown streak disease and diseases that impact cocoa trees and potatoes. A GE bean has been developed in Brazil that is resistant to the golden mosaic virus. Researchers at the University of Florida, the University of California-Berkeley and the 2Blades Foundation have developed a disease resistant GM tomato.

Scientists at the John Innes Center in the UK are attempting to create a strain of barley capable of making its own ammonium fertilizer from nitrogen in the soil. This would be particularly beneficial to farmers who grow crops in poor soil conditions or who lack the financial resources to buy synthetic fertilizers.

Peggy Ozias-Akins, a horticulture expert at the University of Georgia has developed and tested genetically-engineered peanuts that do not produce two proteins linked to intense allergens.

New gene editing techniques (NBTs) such as CRISPR offer great potential and face lower approval hurdles, at least for now.

In June 2017, the EPA approved a new first of its kind GE corn known as SmartStaxPro, in which the plants genes are tweaked without transgenics to produce a natural toxin designed to kill western corn rootworm larvae. It also produces a piece of RNA that shuts down a specific gene in the larvae, thereby killing them. The new GE corn is expected to be commercialized by the end of the decade.

What could slowor even stopthis revolution? In an opinion piece for Nature Biology, Richard B. Flavell, a British molecular biologist and former director of the John Innes Center in the UK, which conducts research in plant science, genetics and microbiology, warned about the dangers of vilifying and hindering new GE technologies:

The consequences of simply sustaining the chaotic status quoin which GMOs and other innovative plant products are summarily demonized by activists and the organic lobbyare frightening when one considers mounting challenges to food production, balanced nutrition and poverty alleviation across the world. Those who seek to fuel the GMO versus the non-GMO debate are perpetuating irresolvable difference of opinion. Those who seek to perpetuate the GMO controversy and actively prevent use of new technology to crop breeding are not only on the wrong side of the debate, they are on the wrong side of the evidence. If they continue to uphold beliefs against evidence, they will find themselves on the wrong side of history.

A version of this article previously ran on the GLP on January 24, 2018.

Steven E. Cerier is a freelance international economist and a frequent contributor to the Genetic Literacy Project

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Genetic engineering, CRISPR and food: What the 'revolution' will bring in the near future - Genetic Literacy Project

[Sickle cell] diseaseis caused by a genetic defect that turns red blood cells into hard, sticky, sickle-shaped cells that dont carry oxygen well, clog the bloodstream, damage organs and cause torturous bouts of pain.

The pain is excruciating. Its like being in a car accident and having lightning in your chest. Its a pain that makes a grown woman like me scream, Gray says. Its an overwhelming pain.

Like many sickle cell patients, Victoria had to drop out of school, quit work and spend weeks in the hospital away from her family. Since many sickle cell patients dont survive past their 40s, Gray worries whether shell live to see her children grow up. She just turned 34.

But Gray has hope now, because in July doctors infused billions of her own bone marrow cells back into her body, after editing them with CRISPR.

Scientists used CRISPR to modify a gene in the cells to make them produce fetal hemoglobin, a protein that babies usually stop making shortly after birth. The hope is that the protein produced through the gene-editing treatment will give sickle cell patients like Gray healthy red blood cells.

Read full, original post: A Patient Hopes Gene-Editing Can Help With Pain Of Sickle Cell Disease

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CRISPR gene editing raises hopes of easing the pain associated with sickle cell disease - Genetic Literacy Project

New York City, NY: October 19, 2019 Published via (Wired Release) Global CRISPR Technology Market Research Reportrepresents the proficient analysis of CRISPR Technology industry providing a competitive study of leading market players, market growth, consumption(sales) volume, key drivers and limiting factors, future projections for the new-comer to plan their strategies for business. Further, the report contains the study of CRISPR Technology market ups and downs of the past few years and forecasts sales investment data from 2019 to 2028.

The CRISPR Technology Report outlining the vitals details which are based on manufacturing region, top players, type, applications and so on will gives the transparent view of Industry. The important presence of different regional and local players of CRISPR Technology market is tremendously competitive. The CRISPR Technology Report is beneficial to recognize the annual revenue of key players, business strategies, key company profiles and their benefaction to the market share.

Download Free Sample Copy of CRISPR Technology Market Report:https://marketresearch.biz/report/crispr-technology-market/request-sample

Top Manufacturers Are Covered in This Report:Thermo Fisher Scientific Inc, Merck KGaA, GenScript Corporation, Integrated DNA Technologies Inc, Horizon Discovery Group, Agilent Technologies Inc, Cellecta Inc, GeneCopoeia Inc, New England Biolabs Inc, Origene Technologies Inc

This research report contains a pictorial representation of important data in the form of graphs, figures, diagrams and tables to make simplified for the users to understand the CRISPR Technology market new trends clearly.

Geographically, report on CRISPR Technology is based on several regions with repect to CRISPR Technology export-import ratio of the region, production and sales volume, share of CRISPR Technology market and growth rate of the industry. Major regions included while preparing the report areNorth America, Latin America, Europe, Middle East, Africa, and Asia Pacific.

The leading players in CRISPR Technology industry are estimated to ahead on these opportunities to invade the global market. CRISPR Technology market size and revenue of key players is assessed using the Bottom-up way.

Reasons for Buying Global CRISPR Technology Market Report

* Report provides in-depth study on changing CRISPR Technology market dynamics.

* Report offers Pin Point study on distinct factors driving and constraining industry growth.

* Technological innovation in market to study CRISPR Technology market growth rate.

* Estimated CRISPR Technology market growth depending on the study of historical and the present size of the industry.

Customize Report AndInquiry For The CRISPR Technology Market Report:https://marketresearch.biz/report/crispr-technology-market/#inquiry

Report Table of Content Gives Exact Idea about Global CRISPR Technology Market Report:

Chapter 1explains CRISPR Technology report necessary market surveillance, product price structure, and study, market scope and size forecast from 2019 to 2028. Although, CRISPR Technology market activity, factors impacting the growth of business also complete analysis of current market holders.

Chapter 2offers detailing of top manufacturers of CRISPR Technology market with their share, sales, and revenue.

Chapters 3, 4, 5studies CRISPR Technology report competitive study based on the type of product, their regional sales and import-export study, the annual growth ratio of the market and the coming years study from 2019 to 2028.

Chapter 6offers a detailed analysis of CRISPR Technology business channels, CRISPR Technology market investors, vendors, CRISPR Technology suppliers, dealers, CRISPR Technology market opportunities and threats.

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Global CRISPR Technology Market Revenue And Value Chain 2019-2028 - The State News - BBState

We are contrasting Seelos Therapeutics Inc. (NASDAQ:SEEL) and CRISPR Therapeutics AG (NASDAQ:CRSP) on their institutional ownership, analyst recommendations, profitability, risk, dividends, earnings and valuation. They both are Biotechnology companies, competing one another.

Earnings & Valuation

Table 1 demonstrates Seelos Therapeutics Inc. and CRISPR Therapeutics AGs top-line revenue, earnings per share (EPS) and valuation.

Profitability

Table 2 hightlights the return on equity, net margins and return on assets of the two companies.

Liquidity

The Current Ratio of Seelos Therapeutics Inc. is 2.5 while its Quick Ratio stands at 2.5. The Current Ratio of rival CRISPR Therapeutics AG is 15.8 and its Quick Ratio is has 15.8. CRISPR Therapeutics AG is better equipped to clear short and long-term obligations than Seelos Therapeutics Inc.

Analyst Ratings

Seelos Therapeutics Inc. and CRISPR Therapeutics AG Ratings and Recommendations are available on the next table.

Meanwhile, CRISPR Therapeutics AGs consensus target price is $62, while its potential upside is 63.55%.

Institutional & Insider Ownership

Institutional investors held 10.4% of Seelos Therapeutics Inc. shares and 50% of CRISPR Therapeutics AG shares. 18.48% are Seelos Therapeutics Inc.s share held by insiders. Insiders Comparatively, held 2% of CRISPR Therapeutics AG shares.

Performance

Here are the Weekly, Monthly, Quarterly, Half Yearly, Yearly and YTD Performance of both pretenders.

For the past year Seelos Therapeutics Inc. had bearish trend while CRISPR Therapeutics AG had bullish trend.

Summary

CRISPR Therapeutics AG beats on 7 of the 10 factors Seelos Therapeutics Inc.

CRISPR Therapeutics AG, a gene editing company, focuses on developing transformative gene-based medicines for the treatment of serious human diseases using its proprietary clustered, regularly interspaced short palindromic repeats associated protein-9 (CRISPR/Cas9)gene-editing platform in Switzerland. The CRISPR/Cas9 technology allows for changes to genomic DNA. It has a collaboration agreement with Vertex Pharmaceuticals, Incorporated to develop, manufacture, commercialize, sell, and use therapeutics; a license agreement with Anagenesis Biotechnologies SAS; and a service agreement with MaSTherCell SA to develop and manufacture allogeneic CAR-T therapies. The company also has research collaboration agreements with Neon Therapeutics and Massachusetts General Hospital Cancer Center to develop novel T cell therapies for cancer. CRISPR Therapeutics AG is headquartered in Basel, Switzerland.

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Reviewing Seelos Therapeutics Inc. (SEEL)'s and CRISPR Therapeutics AG (NASDAQ:CRSP)'s results - MS Wkly