Archive for November, 2014

Dopamine-making neurons derived from human embryonic stem cells.

See correction at end of article.

A rat model of Parkinson's disease has been successfully treated with neurons derived from human embryonic stem cells, according to a study led by Swedish scientists. Its a promising sign for scientists at The Scripps Research Institute and Scripps Health who hope to perform similar therapy on Parkinsons patients, using artificial embryonic stem cells.

In rats and people, neurons that make the neurotransmitter dopamine are essential for normal movement. The cells are destroyed in Parkinson's, leading to the difficulty in movement that characterizes the disease.

Researchers transplanted dopamine-producing cells grown from human embryonic stem cells into the brains of rats whose own dopamine-making neurons had been destroyed. The rats were immune-suppressed so they would not reject the cells. Within five months, the transplanted cells boosted dopamine production to normal levels, restoring normal movement in the rats.

The study was published Thursday in the journal Cell Stem Cell. The senior author was Malin Parmar of Lund University in Lund, Sweden.

The results support the Scripps approach of using the artificial embryonic stem cells, called induced pluripotent stem cells, said Jeanne Loring, who heads the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla. Loring is part of a group called Summit 4 Stem Cell that's raising funds to treat eight Parkinson's patients with their own IPS cells.

Particularly significant is the study's comparison of the effects of dopamine-making neurons derived from fetal cells to that of embryonic stem cells, Loring said by email.

"In the 1980s and 1990s, there were several clinical trials that showed that grafts of fetal brain containing the precursors of dopamine neurons could reverse the effects of Parkinson's disease in some patients," Loring said. "We, and the others developing stem cell therapies, based our plans on the results of those studies, but no one had ever directly compared fetal tissue and human pluripotent stem cell-derived dopamine neurons in an animal model of PD."

Induced pluripotent stem cells appear to have much the same capacity as human embryonic stem cells to generate different tissues and organs.

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Parkinson's stem cell therapy works in rats

Published: Sunday, November 9, 2014 at 9:42 p.m. Last Modified: Sunday, November 9, 2014 at 9:42 p.m.

The condition is cancer of the bone marrow. The average age of onset is early to mid-60s and it appears to occur more commonly in men and African-Americans. There are approximately 20,000 new cases of myeloma each year in the U.S. It is the same as plasma cell myeloma, where malignant cells accumulate within the bone marrow and can cause bones to break with no warning.

Brown, a native Ocalan, has the enthusiasm of a cheerleader over a new support group she has started, called Stomping out Myeloma.

She chose to have meetings at 11 a.m. the second Tuesday of each month as many multiple myeloma patients do not drive at night. The group meets at Howard Academy Safe Haven, 306 NW Seventh Ave., Ocala.

Brown and Linda McCray, also of Ocala, receive treatment for multiple myeloma at UF Health Shands in Gainesville. Melodie Jennings, of Ocala, gets care at the Moffitt Cancer Center in Tampa.

Brown said a high percentage of local patients had no day-time support group.

You can tell people have been holding things in, she said after the groups initial meeting Oct. 14.

She said patients with any type of cancer are welcome, as well as family members and caregivers. The next meeting will take place Tuesday.

Brown, who will turn 50 this month, exhibits a vitality that can cause those who meet her to remark, You dont look like you have cancer.

With a bubbly laugh, she replies, Just what is cancer supposed to look like?

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Local myeloma survivors band together for support

The Binding of Isaac: Rebirth Unlimited Fart Sound Glitch
I played the FART SNDS seed and a bug happened, ED, or tyrone... Tyrone is a black name but he is Hispanic but appears to be white skin... Stem Cells The Bin...

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The Binding of Isaac: Rebirth Unlimited Fart Sound Glitch - Video

Stem Cell Research Therapy Explained - From MS to Spinal Injury
Stem cell treatment and research towards curing illness--from multiple sclerosis to spinal injury--is detailed by Dr. Neil Riordan. The American medical indu...

By: TheLipTV

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Stem Cell Research & Therapy Explained - From MS to Spinal Injury - Video

Dopamine-making neurons derived from human embryonic stem cells.

A rat model of Parkinson's disease has been successfully treated with neurons derived from human embryonic stem cells, according to a study led by Swedish scientists. Its a promising sign for scientists at The Scripps Research Institute and Scripps Health who hope to perform similar therapy on Parkinsons patients, using artificial embryonic stem cells.

In rats and people, neurons that make the neurotransmitter dopamine are essential for normal movement. The cells are destroyed in Parkinson's, leading to the difficulty in movement that characterizes the disease.

Researchers transplanted dopamine-producing cells grown from human embryonic stem cells into the brains of rats whose own dopamine-making neurons had been destroyed. The rats were immune-suppressed so they would not reject the cells. Within five months, the transplanted cells boosted dopamine production to normal levels, restoring normal movement in the rats.

The study was published Thursday in the journal Cell Stem Cell. The senior author was Malin Parmar of Lund University in Lund, Sweden.

The results support the Scripps approach of using the artificial embryonic stem cells, called induced pluripotent stem cells, said Jeanne Loring, who heads the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla. Loring is part of a group called Summit 4 Stem Cell that's raising funds to treat eight Parkinson's patients with their own IPS cells.

Particularly significant is the study's comparison of the effects of dopamine-making neurons derived from fetal cells to that of embryonic stem cells, Loring said by email.

"In the 1980s and 1990s, there were several clinical trials that showed that grafts of fetal brain containing the precursors of dopamine neurons could reverse the effects of Parkinson's disease in some patients," Loring said. "We, and the others developing stem cell therapies, based our plans on the results of those studies, but no one had ever directly compared fetal tissue and human pluripotent stem cell-derived dopamine neurons in an animal model of PD."

Induced pluripotent stem cells appear to have much the same capacity as human embryonic stem cells to generate different tissues and organs.

There has been uncertainty about how similar they are to each other, specifically whether the IPS process produces mutations. But recent studies have found the cell types are extremely similar, including a study also published in Cell Stem Cell on Thursday. That study compared IPS cells with embryonic stem cells produced by SCNT, or somatic cell nuclear transfer, the same process used to create Dolly the sheep.

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Parkinson's stem cell therapy works in rats

OMD@MOL 1/11/2014 GENETIC ENGINEERING
Don #39;t film and dance, and guess who mixed the lyrics up again?!!!!!

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OMD@MOL 1/11/2014 GENETIC ENGINEERING - Video

NEW Sims 3 Challenge - Perfect Genetics - C-A-S Option 2
I will be starting this challenge next month (november but no set date yet) but i want your help in choosing the founder. Over the next 3 weeks i will give y...

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NEW Sims 3 Challenge - Perfect Genetics - C-A-S Option 2 - Video

Jordan ASH | Model Genetics Folio | Dir. TBVision Films
VIDEO PORTFOLIO FOR JORDAN_ASH -ON IG Photo shoot by geeno mizielli dir. by :TBVISION_ ON IG.

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Jordan ASH | Model Genetics Folio | Dir. TBVision Films - Video

Engineering Microenvironments for Stem Cells - Shaochen Chen, UC San Diego
Speaker: Shaochen Chen, Ph.D., Professor, NanoEngineering Bioengineering; Co-Director, Biomaterials Tissue Engineering Center, UC San Diego.

By: Alliance for Regenerative Medicine

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Engineering Microenvironments for Stem Cells - Shaochen Chen, UC San Diego - Video

Ruth DeFries, chair of the department of ecology, evolution, and environmental biology at Columbia University, in New York, and author of The Big Ratchet: How Humanity Thrives in the Face of Natural Crisis, has spent much of her life looking down at Earth from a great height, using satellite images to track human development. But to understand how we went from being hunter-gatherers to a species that so completely dominates the planet, she had to go much further back in time.

Speaking from her home in New York, she guides us from the rain forest of Brazil to the latest developments in foods containing genetically modified organisms (GMOs). On the way she explains why food is at the heart of human civilization, what we need to do to feed the world in the coming decades, and why it's not just the quantity of the food we produce that matters, but also the quality.

My dictionary says a ratchet is either a tool or rap slang for a diva. What's the "Big Ratchet"?

A ratchet is a colloquial urban term, as you suggest. But it's also a mechanical tool. You turn the ratchet in one direction, and you can't go back. The ratchets in the book refer to the ways people have figured out how to manipulate nature to produce food.

Once we have these technologies, we produce more food, ratchet up the population, and that continues on. The Big Ratchet refers to the past 50 years, when we've had an explosive increase in food production. The amount of food produced has surpassed even the explosive growth in population.

So the story of the Big Ratchet is how we got to this point. How we figured out, through genetics, nutrients, irrigation, and pesticides, to lift the constraints that nature placed upon us.

You start your story in the Brazilian rain forest with the Kayapo Indians. Tell us how they feature in modern-day food production and why their story is part of our own evolutionary history.

I was doing work in the Brazilian rain forest using satellite data to track deforestation. That took me down to the ground to a very interesting part of the world, the state of Mato Grosso, in Brazil. At the time, in the early 2000s, it had the highest rate of deforestation in the world. Within that landscape there was a reserve for the Kayapo Indians, who were still living as hunter-gatherers.

So there was this amazing juxtaposition with modern agriculturegiant tractors, planes flying pesticides, everything you think of with modern agriculture for the cultivation of soy and other crops.

But before we started to domesticate plants and animals around ten or twelve thousand years ago, everyone lived like the Kayapo. Everyone hunted for wild animals, foraged for seeds and berries and fruits. That was the way we interacted with nature to get food.

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Humans' Amazing Evolution From Hunter-Gatherer to Safeway Shopper

Big data in Personalized Medicine
80% of genomic data is unstructured. Mark Blatt and Joan Hankin outline how big data enables individual comparison to revolutionize diagnosis and treatment in the healthcare industry.

By: Intel UK

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Big data in Personalized Medicine - Video

The Expanding Role of the Genomic Counselor in Personalized Medicine - Rebecca Nagy, M.S., CGC
Ms. Nagy is a certified genetic counselor and clinical associate professor of internal medicine at The Ohio State University #39;s Wexner Medical Center in Colum...

By: Mayo Clinic

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The Expanding Role of the Genomic Counselor in Personalized Medicine - Rebecca Nagy, M.S., CGC - Video

Spinal Cord Injury in a Car Accident Healed | Ravi Abraham Miracles 2014
Mr. Anup Kumar Mohapatro,whose Spinal Cord was severely damaged in a Car accident, was healed instantly healed after prayer. SUNDERGARH HIGHLIGHTS - 6.

By: Ravi Abraham

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Spinal Cord Injury in a Car Accident Healed | Ravi Abraham Miracles 2014 - Video

Epigenetics Stem Cells in Development Regenerative Medicine - Pier Lorenzo, Sanford-Burnham
Speaker: Pier Lorenzo Puri, M.D., Ph.D., Associate Professor, Development, Aging Regeneration Program, Sanford-Burnham Medical Research Institute.

By: Alliance for Regenerative Medicine

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Epigenetics & Stem Cells in Development & Regenerative Medicine - Pier Lorenzo, Sanford-Burnham - Video

Epigenetics Stem Cells in Development Regenerative Medicine - Allen Wang, UC San Diego
Speaker: Allen Wang, Ph.D., Postdoctoral Fellow, Department of Pediatrics, UC San Diego.

By: Alliance for Regenerative Medicine

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Epigenetics & Stem Cells in Development & Regenerative Medicine - Allen Wang, UC San Diego - Video

Blue Horizon Stem Cells and the Promise of Regenerative Medicine

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Blue Horizon Stem Cells and the Promise of Regenerative Medicine - Video

Adult stem cells: key to regenerative medicine - do you know?
Regenerative medicine is poised to dramatically alter conventional methods of treatment, shifting the focus away from symptoms and targeting the specific causes of different defects. Within...

By: euronews Knowledge

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Adult stem cells: key to regenerative medicine - do you know? - Video

Last year, Maria Tun was in the audience at Hancock College's Bridges to the Baccalaureate Fall Symposium watching fellow students present their summer research projects. On Friday, she was explaining her participation in a Cal Poly gene research program.

The 20-year-old Tun worked Sandra Clement, an assistant professor in Cal Poly's Biological Sciences Department, on "post-transcriptional and post-translational regulation of gene expression by cell signaling pathways in mammalian cells." That is an accurate, but extensively technical description of research that scientists hope will one day eliminate diseases and birth defects.

"It was mainly focused on genetics. Basically they just want to regulate protein levels so that they create different functions of different genes at different times," said Tun, a 2012 graduate of Pioneer Valley High School, sounding very much like a seasoned research assistant. "The first step is to regulate a gene. Once youre able to regulate a gene, that goes back regulating protein levels that regulates a gene. Eventually through more research it'll lead to regulating any type of gene, so you could stop cancerous genes before they start."

The two-and-a-half month summer program allowed Tun to work with Clement's research team at Cal Poly. It not only opened her eyes to genetic research, it most likely was the first step in what she wants to be a career in genetics research.

"Obviously I wanted to do something in the science department, but after doing the genetics program with Bridges, thats where I'm focused," she said, adding her ultimate goal would be to join Clement's team at Cal Poly.

The University of California, Irvine is another possibility, she said.

The Bridges to the Baccalaureate program is a partnership between Cal Poly and Hancock College designed to give underrepresented minority students a chance to pursue careers in the biomedical or behavioral sciences.

This summer, Tun was one 13 Bridges students who had paid research internships at Cal Poly. Over the past five years, 65 Hancock students have been accepted into the program and 40 of them have transferred to four-year universities, including Cal Poly.

Len Miyahara, who wrote the grant that started the program and now serves as its director, said budget cuts have curtailed the program in recent years. When it started, Hancock College was one of eight such programs in the country. Miyahara said it is now one of three.

Last month, the National Institutes of Health Division of Minority Opportunities in Research awarded a five-year $966,000 grant to extend the program.

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Hancock College program spans education gap

Genetics of Scleroderma: Towards Personalized Medicine in the Genomic Age
Presented by Benjamin Korman, MD at the Scleroderma Patient Education Conference on October 11, 2014. Hosted by the Scleroderma Foundation, Greater Chicago Chapter and the Northwestern ...

By: Scleroderma Foundation, Greater Chicago Chapter

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Genetics of Scleroderma: Towards Personalized Medicine in the Genomic Age - Video

Brust/Bizeps Workout + Posing - Iron-Genetics- Tolga Gn
Servus Leute, hier fr euch mein Brust/Bizeps Workout + Posing. Zum Schluss ein paar Kritikpunkte zum Thema, training im Fitnessstudio. Instagram: Iron_Gene...

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Brust/Bizeps Workout + Posing - Iron-Genetics- Tolga Gn - Video

[1.09] How to use medical items
1) Pick up pills/gene therapy/bandages/med kit 2) Open your inventory wheel by pressing 1, and click on the item 3) Once you see a pair of hands, tap your left mouse button You can still shove...

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[1.09] How to use medical items - Video

Stem Cell Therapy for Pets in Central Florida
http://www.NewmanVets.com Call your local Newman Veterinary Center for more information about stem cell therapy for pets. https://www.youtube.com/watch?v=7X23bmsy0Q8 feature=youtu.be.

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Stem Cell Therapy for Pets in Central Florida - Video

Stem Cell Therapy for Multiple Sclerosis: Ron McGill
Ron McGill suffers from relapsing-remitting multiple sclerosis. He was started experiencing symptoms in 2009 but was not diagnosed with MS until January of 2013. He received several infusion...

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Stem Cell Therapy for Multiple Sclerosis: Ron McGill - Video

WALES NEWS

The family of eight-year-old Hollie Clark broke the news yesterday on the Facebook page that they used to raise awareness of her battle with the bone marrow disorder MDS.

As part of a social media campaign to find a donor, celebrities including football player Gareth Bale posed with their underwear on their heads to rise awareness.

Hollie's father Stephen, of Penylan, Cardiff, wrote: "Sad news today I'm afraid. After a seven month battle with MDS Hollie passed away peacefully in her parents' arms.

"It is utterly heartbreaking and makes no sense.

"We have a million memories and take huge comfort in the number of Anthony Nolan registrations that the campaign made.

"We are sure that someday soon one of you will be asked to donate stem cells and give someone like Hollie a chance.

"Thank you all for your support. We would appreciate some time and space to try and pick ourselves up.

"Love from Hollie's Dad. The proudest Dad in the world."

WALES NEWS

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'Utterly heartbreaking' Family mourn girl who sparked social media bone marrow campaign

(Ivanhoe Newswire) CLEVELAND, Ohio -- In 1990 the Human Genome Project started. It was a massive scientific undertaking that aimed to identify and map out the body's complete set of DNA. This research has paved the way for new genetic discoveries; one of those has allowed scientists to study how to fix bad chromosomes.

Our bodies contain 23 pairs of them, 46 total. But if chromosomes are damaged, they can cause birth defects, disabilities, growth problems, even death.

Case Western scientist Anthony Wynshaw-Boris is studying how to repair damaged chromosomes with the help of a recent discovery. He's taking skin cells and reprogramming them to work like embryonic stem cells, which can grow into different cell types.

You're taking adult or a child's skin cells. You're not causing any loss of an embryo, and you're taking those skin cells to make a stem cell. Anthony Wynshaw-Boris, M.D., PhD, of Case Western Reserve University, School of Medicine told Ivanhoe.

Scientists studied patients with a specific defective chromosome that was shaped like a ring. They took the patients' skin cells and reprogrammed them into embryonic-like cells in the lab. They found this process caused the damaged ring chromosomes to be replaced by normal chromosomes.

It at least raises the possibility that ring chromosomes will be lost in stem cells, said Dr. Wynshaw-Boris.

While this research was only conducted in lab cultures on the rare ring-shaped chromosomes, scientists hope it will work in patients with common abnormalities like Down syndrome.

What we're hoping happens is we might be able to use, modify, what we did, to rescue cell lines from any patient that has any severe chromosome defect, Dr. Wynshaw-Boris explained.

It's research that could one day repair faulty chromosomes and stop genetic diseases in their tracks.

The reprogramming technique that transforms skin cells to stem cells was so ground-breaking that a Japanese physician won the Nobel Prize in medicine in 2012 for developing it.

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Stem cells to repair broken chromosomes