Archive for November, 2014

The Sims 4: Perfect Genetics Legacy [Part 1] Getting Started
We have decided to take on the Legacy Challenge, but we are adding a little change to the concept. We are adding in the Perfect Genetics Challenge into the mix. With that in mind it changes...

By: Connor K Games

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The Sims 4: Perfect Genetics Legacy [Part 1] Getting Started - Video

Mcpe Genetics Mod (Fly,Infinite Milk,Eat Grass)
Genetics Mod! I will make an update video if they add anything A like and/or comment would be much apreciated 🙂 mOD : http://mcpedl.com/molecular-genetics-mod/ Follow me! Twitter : https://twi...

By: Cheesey Knucles

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Mcpe Genetics Mod (Fly,Infinite Milk,Eat Grass) - Video

Genetics plays - Don #39;t Give Up
September 21, 2013 Teatro Coliseo, Buenos Aires, Argentina Official Facebook page https://www.facebook.com/geneticsband.

By: Genetics

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Genetics plays - Don't Give Up - Video

Gene Therapy- Channel 4 news
Anchor Josh Barnette interviews Sydney Brooks and Hunter White and talks about their groundbreaking research in the field of genetics.

By: Hunter White

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Gene Therapy- Channel 4 news - Video

Dr Zwerling on Gene Therapy
Ian #39;s school project.

By: Ian Zwerling

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Dr Zwerling on Gene Therapy - Video

http://clinicaltrials.gov/ct2/show/record/NCT02176317 Umbilical cord blood (UCB) has been shown to lessen the clinical and radiographic impact of hypoxic brain injury and stroke in animal models and in infants with hypoxic ischemic encephalopathy. UCB also engrafts and differentiates in the brain, facilitating neural cell repair in animal models and human patients with inborn errors of metabolism undergoing allogeneic, unrelated donor UCB transplantation. Infusion of autologous UCB does not require immunosuppression and has been shown to be safe in young children with brain injuries such as cerebral palsy and stroke. In this study, the investigators hypothesize that infusion of a patients own umbilical cord blood cells (UCB) can offer neural protection/repair in the brain and reduction of inflammation associated with this disorder.

DUKE STEM CELL AUTISM TRIAL

Theres a lot of skepticism surrounding this trial using cord blood stem cells to treat autism. Apparently, the concerns are:

1. Autism is a name given to a whole host of diseases yet to be named, ie. many different symptoms. Stem cells are part of the natural healing system in the body. They are smart and migrate to fix damaged tissue and cells. Stem cells work within your body in conjunction with your physiology. You can try to train and control them but they have a mind of their own. For ex: When cardiac stem cells are injected into the heart, they often finish their work and then migrate down to the Pancreas and fix it. IV implantation is very much in keeping with this idea and relies on the stem cells smart capabilities. On a certain level, we dont need to know what is broken. They do. A soldier is trained to respond to orders, then told what to do and they damn well do it. Marines are taught to adapt, improvise, overcome and often sent into battle with limited intel. When faced with an obstacle, they change their strategy and create a new one to succeed. Both are very valuable. Stem cells are born Marines.

2. We dont know what causes Autism so we cant treat it. The people saying we dont know what causes Autism are the same people who knew cardiac cells dont regenerate, central nervous system cells dont regenerate, only Embryonic stem cells have value, Margarine is better than Butter, etc. Wrong, wrong, wrong, wrong.

There are more things in heaven and earth, Horatio, Than are dreamt of in your philosophy. Hamlet (1.5.167-8), Hamlet to Horatio

Our knowledge is incredibly limited. As time goes on, we learn more and everything we held as inviolate becomesviolated. Taking into consideration that everything we know will be proven wrong in a few decades and then wrong again in another few after that as we learn morepeople should probably stop blocking treatments because of what they know or in this case, dont know.

This just popped up and I had to add it. Regulation of developmental gene expression occurs in the reverse order to that expected http://phys.org/news/2014-07-developmental-gene-reverse.html modifications involving Polycomb proteins occur in a manner that contradicts existing models.

3. Stem cells cant make it into the brain where the damage is. This is a test for safety of stem cells in Autistic children so efficacy is only a secondary consideration. Lets see if they tolerate a small amount of stem cells first before giving them a full dose, though I see no reason why they wouldnt. Duke U. is where a number of successful pediatric cord blood/Cerebral Palsy trials were held. http://repairstemcell.wordpress.com/2012/04/10/cerebral-palsy-and-stem-cells/ CP involves the brain. Stem cells have a history of success with Ataxia, Traumatic Brain injury, etc. etc.

Conclusion:

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The Stem Cell Blog | Adult Stem Cell Patient Empowerment

Beverly Hills, California (PRWEB) November 17, 2014

Veteran television and movie actor Darius McCrary has received a revolutionary stem cell procedure for his painful knee and ankle. The regenerative medicine procedure with stem cells was performed by Dr. Raj, a top orthopedic doctor in Beverly Hills and Los Angeles.

Darius McCrary is well known for his decade long stint on Family Matters as character Eddie Winslow. He won a Best Young Actor Award for this role along with movie roles in both Mississippi Burning and Big Shots. Currently, Darius appears along with Charlie Sheen in the show Anger Management.

While staying in tip top shape for his career, Darius has developed persistent pain in his right knee and ankle. Rather than seek a regular cortisone injection for pain relief or opt for surgery, he desired the ability to repair the joint damage and achieve pain relief. "I couldn't imagine being immobilized because of injury, so I opted for a stem cell procedure."

The procedures were performed by Dr. Raj, who is a prominent Beverly Hills orthopedic doctor with extensive experience in regenerative medicine. The procedure consisted of a combination of platelet rich plasma therapy along with amniotic derived stem cell therapy. Anecdotal studies are showing that the stem cell procedures for extremity joints allow patients to achieve pain relief and often avoid the need for potentially risky surgery.

Dr. Raj has performed over 100 stem cell procedures for patients who have degenerative arthritis or sports injuries. "Patients do extremely well with the procedures. Minimal risk and there's a huge potential upside!"

With an active acting career, Darius McCrary cannot afford to be distracted with chronic pain. "I'm looking forward to getting back in the gym and going hard without this pain," he stated excitedly. The procedure was filmed and can be seen on Dr. Raj's Facebook page.

To discuss stem cell procedures at Beverly Hills Orthopedic Institute and how they can benefit, call (310) 247-0466.

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Veteran Actor Darius McCrary from Family Matters Receives Stem Cell Procedures with Dr. Raj in Beverly Hills

You no longer have to be Rich and famous to experience the Profound Healing effects and Intense Revitalizing and Anti-Aging benefits of MFIII (MF3) Live Cell Therapy - the best anti-aging product available in the world! Thanks to Swiss innovation and Technology, this amazing anti-aging product is now available for the first time in 70 years, and some refer to this scientific breakthrough in anti-aging and looking young as the Stem Cell in a Capsule.

Whether you are sick or experiencing chronic fatigue or just seeking the best Anti-aging and Skin Beauty supplement, everyone will benefit from the rejuvenation and regeneration of MFIII of Switzerland Live Cell Therapy. Best of all, it's acompletely Natural and Safe anti-aging solution, facilitatating and enhancing the body's ability to heal itself naturally, free from any side effects.

At last, you can feel younger, reduce cellular aging and feel full of vitality, energy, and dynamism in around 3-6 weeks with MFIII Switzerland hi-tech oral supplement formulation. MF III ( MF3) Sheep and Vegetal Placenta helps to awaken dormant cells inside the body, thereby enhancing the expression and function of existing cells, revitalizing and regenerating old and malfunctioning cells. This amazing anti-aging supplement offers what vitamins, minerals, hormones, chemicals and other typical treatments can't to worn out cells. It facilitates the processes and actual requirements for cellular functioning, mandatory for aged, hurt or sick organs and tissues to fix and regenerate, therefore providing amazing age-defying, health beauty benefits at the very same time.

Cell Treatment (or Live Cell Therapy) was first invented in an injectible form by Swiss surgeon Dr Paul Niehans in 1931. As you'll soon learn: Cell Therapy is essentially the forerunner of the better-known Human Stem Cell Therapy, which was invented in the 1960s based mostly on the principle of Cell Therapy.

Due to their intense health and beauty benefits but exceedingly high cost, Cell Therapy injections have for a while been a celebrity secret in protecting a young appearance and supporting critical health problems. Pope Pius XII was so happy with the treatment that he inducted Dr Paul Niehans, the deviser of Cell Therapy, into the Papal Academy of Science, making him the successor to the late Sir Alexander Fleming, the discoverer of penicillin.

Many celebrities, presidents and members of the Swiss Soccer World Cup team have benefited from Cell Therapy. President Eisenhower, Prime Minister Winston Churchill, and French General De Gaulle received it to maintain their powers of concentration and their physical endurance. Adenauer credited live cell therapy with giving him the energy to guide the Republic of Germany though he was more than ninety years old.

Charlie Chaplin claimed it enabled him to marry again and father kids after age seventy. Exclusive hospitals for the wealthy & famous in Switzerland have administered the Anti-Aging Cell Therapy to both western and oriental celebs, improving and lengthening their vigor and conserving their young appearance and capabilities.

Actress of "Law & Order"

"There is NO compromise for quality and effectivenes. I won't settle for anything else"

European Model

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Authorized MFIII (MF3) - Cell Placenta Therapy For Anti-Aging

e-cell: energy for life

The e-cell is a personal and portable 'bio-electronic' device that stimulates the bodys own natural healing processes. It utilises a unique programmed electromagnetic field, with each therapy card designed accordingly to meet specific tissue types and the healing stage of your injury. These Smart cards are available specifically for the Shoulder, Elbow, Wrist, Neck Mid back, Low Back, Hip, Knee, Ankle, Bone, and Vascular. Just 30 minutes a day will speed the recovery of those strains and pains you are suffering.

Using innovative technology originally developed by NASA scientists to simulate physical exercise for its astronauts, the e-cell has a proven record of results through extensive clinical trails over a 23 year period.

The e-cell replicates and amplifies the bodys own natural repair and regeneration process by simulating exercise at a cellular level. It encourages 'dormant' cells to absorb nutrients again, enabling them to repair thus resulting in the relieving of pain symptoms.

for more on this ground-breaking device including detailed information on the application of Therapy cards and purchasing options.

is the sole distributor of the e-cell in the UK and has nearly 35 years experience as a worldwide wholesale distributor and exporter of pharmaceutical and medical supplies.

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e-cell ElectroMagnetic Therapy Energy cell portable drug ...

Space Station 13 : Genetics And Weird Sounds.
Its my first Vid i know its Bad,Please Subscribe,Or like.

By: BlubyFish

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Space Station 13 : Genetics And Weird Sounds. - Video

Gene therapy could be a way to fix a genetic problem at its source. By adding a corrected copy of a defective gene, gene therapy promises to help diseased tissues and organs work properly. This approach is different from traditional drug-based approaches, which may treat symptoms but not the underlying genetic problems.

Most commonly, gene therapy uses a vector, typically a virus, to deliver a gene to the cells where it's needed. Once it's inside, the cell's gene-reading machinery uses the information in the gene to build RNA and protein molecules. The proteins (or RNA) can then carry out their job in the cells.

But gene therapy is not a molecular bandage that will automatically fix any genetic problem. While many disorders or medical conditions can potentially be treated using gene therapy, others are not suitable for this approach. So what makes a condition a good candidate for gene therapy?

Could the condition be corrected by adding one or a few functional genes? For you to even consider gene therapy, the answer must be "yes." For instance, genetic disorders caused by mutations in single genes tend to be good candidates for gene therapy, while diseases involving many genes and environmental factors tend to be poor candidates.

Do you know which genes are involved? If you plan to treat a genetic flaw, you need to know which gene(s) to pursue. You must also have a DNA copy of the gene available in your laboratory.

Do you understand the biology of the disorder? To design the best possible approach, you need to learn all you can about how the gene factors into the disorder. For example, which tissues the disorder affects, what role the protein encoded by the gene plays within the cells of that tissue, and exactly how mutations in the gene affect the protein's function.

Will adding a normal copy of the gene fix the problem in the affected tissue? Or could getting rid of the defective gene fix it? Sometimes when a gene is defective, no functional protein is being made from it. In cases like these, adding a functional copy of the gene could correct the problem. But sometimes a defective gene codes for a protein that starts doing something it shouldn't or prevents another protein from doing its job. In order to correct the problem, you would need to get rid of the misbehaving protein.

Can you deliver the gene to cells of the affected tissue? The answer will come from several pieces of information, including the tissue's accessibility and molecular signatures.

APA format: Genetic Science Learning Center (2014, June 22) What is Gene Therapy?. Learn.Genetics. Retrieved November 16, 2014, from http://learn.genetics.utah.edu/content/genetherapy/gtintro/ MLA format: Genetic Science Learning Center. "What is Gene Therapy?." Learn.Genetics 16 November 2014 <http://learn.genetics.utah.edu/content/genetherapy/gtintro/> Chicago format: Genetic Science Learning Center, "What is Gene Therapy?," Learn.Genetics, 22 June 2014, <http://learn.genetics.utah.edu/content/genetherapy/gtintro/> (16 November 2014)

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What is Gene Therapy? - Learn Genetics

PUBLIC RELEASE DATE:

15-Nov-2014

Contact: Kurtis Pivert kpivert@asn-online.org 202-699-0238 American Society of Nephrology @ASNKidney

Philadelphia, PA (November 15, 2014) -- The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented at ASN Kidney Week 2014, November 11-16 at the Pennsylvania Convention Center in Philadelphia, PA.

ACT-AKI: A Phase 2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of AC607 for the Treatment of Acute Kidney Injury in Cardiac Surgery Subjects

ADVANCE-ON: long term benefits of intensive glucose control for end-stage kidney disease

HALT Progression of Polycystic Kidney Disease (HALT PKD) Trials: Primary Results of a 2x2 Factorial Trial in Early Stage CKD HALT Progression of Polycystic Kidney Disease Trials: Primary results of a randomized trial in moderately advanced stage CKD

Impact of Extended Weekly Hemodialysis Hours on Quality of Life and Clinical Outcomes: the ACTIVE Dialysis Multinational Trial

Randomized Clinical Trial of Ergocalciferol Supplementation in 25 Vitamin D Deficient Hemodialysis Patients

Renal Efficacy and Safety of Anti-TGF-1 Therapy in Patients with Diabetic Nephropathy

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High impact clinical trials yield results that could lead to improved kidney care

What is a Stem Cell Support Serum? | RG Cell | Agerite Solutions
What is a Stem Cell Support Serum? Paloma: And I suppose my next question would be what is a stem cell support serum? Dean: Well, in skin care, serums are co...

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What is a Stem Cell Support Serum? | RG Cell | Agerite Solutions - Video

Stem cells are the building blocks of your skin. They have a unique ability to replace damaged and diseased cells. As they divide, they can proliferate for long periods into millions of new skin cells.

As we age, our stem cells lose their potency. Your skin's ability to repair itself just isn't what it used to be. The result can be fine lines, wrinkles, age spots, and sagging skin. But non-embryonic stem cells -- the same stem cells active early in life -- are highly potent. Lifeline anti-aging stem cell serums tap into the potency of these stem cells to help renew your skin.

Scientists at Lifeline Skin Care discovered that human non-embryonic stem cell extracts can help renew skin -- by replacing old cells with healthy new ones. These stem cell extracts help stimulate your own skin's abilities to repair itself. And Lifeline anti-aging stem cell serums were born.

Where Stem Cells in Anti Aging Products Come From

The first types of human stem cells to be studied by researchers were embryonic stem cells, donated from in vitro fertilization labs. But because creating embryonic stem cells involves the destruction of a fertilized human embryo, many people have ethical concerns about the use of such cells.

Lifeline Skin Care (through its parent company, ISCO) is the first company in the world to discover how to create human non-embryonic stem cells -- and how to take extracts from them. As a result, you need never be concerned that a viable human embryo was damaged or destroyed to create these anti-aging products.

The non-embryonic stem cells in Lifeline stem cell serums are derived from unfertilized human oocytes (eggs) which are donated to ISCO from in vitro fertilization labs and clinics.

Lifeline Anti Aging Stem Cell Serums are Based in Science

Lifeline Skin Care's exclusive anti-aging products are a combination of several discoveries and unique high-technology, patent-pending formulations.

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Anti Aging Stem Cell Serums Renew Skin - Life Line Skin Care

Gene Therapy: Choroideremia
It #39;s a form of blindness that some call especially cruel. People with choroideremia are born with perfect vision and then begin to lose their sight, sometimes as kids or teens.

By: NewsChannel 5

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Gene Therapy: Choroideremia - Video

Eli Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA
In a specially designed facility that is compliant with FDA Good Manufacturing Practices (GMP) requirements, scientists with the Eli and Edythe Center of Regenerative Medicine and Stem Cell...

By: UCLA Eli Edythe Broad Center of Regenerative Medicine and Stem Cell Research

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Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA - Video

SINGAPORE: It was anemotional meeting for bone marrow transplant recipient Ivan Wijaya. On Friday (Nov 14), he finally came face to face with his bone marrow donor Ms Enning Yeo, more than a year after his transplant operation last October.

Ivan, 29, was diagnosed with Acute Myelogenous Leukaemia in February last year and never imagined being alive today, because finding a match is 1 in 20,000.

"When I was diagnosed with leukaemia, I just felt that I will be dead soon. But I didn't cry and I toughened myself because I didn't want to let my wife down. But in my heart, I still felt scared and didn't know what to do, he said.

Enning, who is 28, signed up for the Bone Marrow Donor Programme in 2006. She likened being selected as a donor to striking a charity lottery.

"It is an altruistic act but on a personal level, I do feel a sense of satisfaction and achievement. People talk about a bucket list of things to do. I don't have my own bucket list but if I did have one, but if I could have check off - that I saved a life - even if it's simply by donating bone marrow is something I'm very proud of, she said.

This year, 19 local donors have taken part in successful bone marrow transplants in Singapore. There were seven such donors last year.

These numbers were revealed by the Bone Marrow Donor Programme, a non-profit organisation that manages Singapore's only register of volunteer bone marrow donors. But with about 50 bone marrow transplant requests received monthly, more donors are needed.

To date, the Bone Marrow Donor Programme has some 48,000 donors on its register. But with an increasing demand for bone marrow transplants, there is an urgent need to recruit more especially from the minority groups. The aim is to recruit 7,000 new donors each year to meet this increasing demand.

CLEARING MISCONCEPTION ABOUT HARVESTING PROCEDURE A CHALLENGE

But a main challenge to get more donors on board is clearing the misconception about the harvesting procedure.

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Donor meets recipient of bone marrow transplant for the first time

CANCER RESEARCH UK scientists have found more than 400 blind spots in DNA which could hide cancer-causing gene faults, according to research published in Cancer Research.

The researchers found hidden faults in areas that are tricky for gene-reading technology to decode. This technique, which unravels cancers genetic blueprint, is an important part of the research that scientists carry out to understand more about cancers biology.

By finding new ways to unlock these blind spots in the future, the researchers hope this will help us understand these mistakes and whether they lead to cancer. This could be a step towards developing tests to spot cancers earlier or provide new tactics for discovering future cancer treatments.

The team, from the Cancer Research UK Manchester Institute, compared two giant gene databases made from cancer cells grown in labs and cross-checked all the genes that are known or are likely to be involved in cancer to unearth the problem areas.

They found that the 400 blind spots in the genes were hidden in very repetitive DNA areas which cause the gene-reading technology to stutter. This problem reading the genes could conceal mistakes which might play a vital role in cancer.

Lead researcher Andrew Hudson, at the Cancer Research UK Manchester Institute at The University of Manchester, said: The genes behind cancer are like a story. While weve been able to read most of the book using gene-reading technology, the limits of these tools mean some pages are missing.

These pages could just be unimportant filler, but we wonder if they might hold important twists in the plot which could affect our understanding of cancer. The next step in our work will be to find a way to open up these areas to help piece together the full story.

Nell Barrie, Cancer Research UKs senior science information manager, said: Were at an unprecedented point in cancer research. As research accelerates were revealing more and more about cancers secrets and central to this is our better understanding of how genetic changes drive the disease.

By delving deeper into cancers genetic origins we can spot the ways the disease is triggered and develops. This could help us to tackle it from the root, giving more cancer patients a chance at surviving the disease.

The University of Manchester, including the Cancer Research UK Manchester Institute, joined forces with Cancer Research UK and The Christie NHS Foundation Trust to form the Manchester Cancer Research Centre, allowing doctors and scientists to work closely together to turn scientific advances into patient benefits sooner.

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Scientists uncover vast numbers of DNA 'blind spots' that may hide cancer-causing mistakes

Latest Infectious Disease News

THURSDAY, Nov. 13, 2014 (HealthDay News) -- It may be possible to identify different types of hemorrhagic fevers -- including one related to Ebola -- before people develop symptoms, according to new research.

Scientists studied two hemorrhagic fevers, including a cousin of Ebola called Marburg and another called Lassa. Marburg causes occasional outbreaks in Africa that have high death rates, and Lassa is common is Western Africa, the researchers reported.

Using genetic material from white blood cells, researchers from the Boston University School of Medicine and the U.S. Army Medical Research Institute were able to recognize changes in the way the genes behaved in the early stages of infection. These changes occur before someone would even have symptoms, according to the researchers. They also occur before the infection could be passed to others, according to the study published recently in the journal BMC Genomics.

The findings could help lead to better ways to diagnose hemorrhagic fevers during the early stages, when treatments and containment efforts are more likely to be effective, the researchers suggested.

They noted that early indications of hemorrhagic fevers (fever, flu symptoms) are similar, which makes proper diagnosis difficult. More disease-specific symptoms and the ability to spread the virus from person to person don't begin until after the virus has accumulated in the blood.

"The ability to distinguish between different types of infection before the appearance of overt clinical symptoms has important implications for guiding triage and containment during epidemics," study corresponding author Nacho Caballero, a Ph.D. candidate at Boston University School of Medicine, said in a university news release.

"We hope that our study will help in the development of better diagnostics, especially during the early stages of disease, when treatments have a greater chance of being effective," he added.

However, Caballero noted that "this is not a finding that can be translated into a test tomorrow. This study supports the idea that early markers of infection are there, but significant work will still need to be done to extend these findings."

-- Robert Preidt

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Gene Analysis May Help Spot Ebola-Like Illnesses Before Symptoms Appear

PUBLIC RELEASE DATE:

14-Nov-2014

Contact: Michael Kennedy m.kennedy@utoronto.ca 416-946-5025 University of Toronto @UofTNews

Researchers from the University of Toronto (U of T) report that personalized dietary advice based on a person's genetic makeup improves eating habits compared to current "one-size-fits-all" dietary recommendations. The findings were published online today in the journal PLoS One.

"We conducted the first randomized controlled trial to determine the impact of disclosing DNA-based dietary advice on eating habits," says Ahmed El-Sohemy, an Associate Professor in Nutritional Sciences at U of T and Canada Research Chair in Nutrigenomics. "We found that people who receive DNA-based advice improve their diet to a greater extent than those who receive the standard dietary advice. They're also the ones who need to change it the most."

Nutrigenomics is a field of research that aims to understand why some people respond differently than others to the same foods. Personalized nutrition, a branch of personalized medicine, is an application of nutrigenomics that helps tailor dietary recommendations to a person's DNA.

The researchers collected data on the intake of caffeine, sodium, vitamin C and sugar from 138 healthy young adults. The subjects were then randomized into two different study groups--one was given DNA-based dietary advice for each of the four dietary components of interest, and the other group was given current standard dietary advice for the same dietary components with no genetic information.

Changes in their dietary habits were assessed after three and 12 months. The researchers found that subjects who received DNA-based dietary advice started to show improvements to their diets after three months and the changes became even more apparent after 12 months.

Specifically, those who were informed that they carried a version of a gene linked to salt intake and high blood pressure significantly reduced their sodium intake, in accordance with the recommendation, compared to the group that received the standard advice for sodium intake.

No effects were observed for the other components of the diet. However, most subjects were already meeting the dietary recommendations for the three other components at the start of the study, and the researchers believe this might explain why no significant changes were seen in these intakes.

Originally posted here:
Genetic testing for personalized nutrition leads to better outcomes

PUBLIC RELEASE DATE:

14-Nov-2014

Contact: Crystal Mackay crystal.mackay@schulich.uwo.ca 519-661-2111 x80387 University of Western Ontario @mediawesternu

Researchers at Western University are using cutting-edge genetic mutation-analysis software developed in their lab to interpret mutations in tumour genome that may provide insight into determining which breast cancer tumours are more likely spread to other parts of the body and which ones won't.

Their findings are published today in the journal, Nature Scientific Reports.

"We are using a unique software program in our lab that looks at a type of mutation called a splicing mutation that is typically overlooked using current methods," said lead author on the study, Stephanie Dorman, a PhD student in the department of biochemistry at Western University's Schulich School of Medicine & Dentistry. She said that where previous genetic studies of 445 tumours detected 429 of these splicing mutations, the Western-developed analysis software was able to find more than 5000.

Using this software and human tumour tissue sample genetic data from The Cancer Genome Atlas, the research team pinpointed that mutations in the Neural Cell Adhesion Molecule (NCAM) and other related genes in NCAM biology were present at a much higher rate in tumours which had metastasized to the lymph nodes than those that did not. NCAM, typically found in neural cells is also highly expressed in breast tissue, and is involved in communication between cells.

"We believe that mutations in these biological pathways in some patients might be causing some of the characteristics of the tumour that enable it to migrate to other parts of the body," said Dorman.

Dr. Peter Rogan, principal investigator on the study and a Professor in the Departments of Biochemistry and Computer Science, hopes that these findings will allow oncologists and clinical laboratories looking for these mutations in tumour biopsies to predict which women are at higher risk for more aggressive tumours that might metastasize.

"One of the big issues in breast oncology is that women are sometimes treated with chemotherapy even if their tumour isn't going to metastasize," said Rogan. "The ideal situation would be to be able to identify those patients where the side-effects and potential negative consequences of chemotherapy following surgery can be avoided or at least, minimized."

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Cutting-edge computer software helps pinpoint aggressiveness of breast cancer tumors

November 14, 2014

Provided by Michael McCarthy, University of Washington Health Sciences/UW Medicine

New technology closes many gaps in mapping that have long resisted sequencing

Thousands of never-before-seen genetic variants in the human genome have been uncovered using a new sequencing technology. These discoveries close many human genome mapping gaps that have long resisted sequencing.

The technique, called single-molecule, real-time DNA sequencing (SMRT), may now make it possible for researchers to identify potential genetic mutations behind many conditions whose genetic causes have long eluded scientists, said Evan Eichler, professor of genome sciences at the University of Washington, who led the team that conducted the study.

We now have access to a whole new realm of genetic variation that was opaque to us before, Eichler said. He and his colleagues reported their findings Nov. 10 in the journal Nature.

To date, scientists have been able to identify the genetic causes of only about half of inherited conditions. This puzzle has been called the missing heritability problem. One reason for this problem may be that standard genome sequencing technologies cannot map many parts of the genome precisely.

These approaches map genomes by aligning hundreds of millions of small, overlapping snippets of DNA, typically about 100 bases long, and then analyzing their DNA sequences to construct a map of the genome.

This approach has successfully pinpointed millions of small variations in the human genome. These variations arise from substitution of a single nucleotide base, called a single-nucleotide polymorphisms or SNP.

The standard approach also made it possible to identify very large variations, typically involving segments of DNA that are 5,000 bases long or longer. But for technical reasons, scientists had previously not been able to reliably detect variations whose lengths range from about 50 bases to 5,000 bases in length.

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Thousands Of Never-Before-Seen Human Genome Variations Uncovered

Cartilage Regeneration
Christopher H. Evans, Ph.D., Director of Rehabilitation Medicine Research Center, Mayo Clinic PM R, discusses his lecture at AAPM R 2014 on the damage done to cartilage from trauma and arthritis.

By: Mayo Clinic

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Cartilage Regeneration - Video

BA2762: The Balancing Act on Lifetime Talks Organic Produce, Personalized Medicine
Today #39;s show focuses on organic produce from farm to plate -- and healthy recipes that help kids eat more vegetables; plus personalized medicine and advancem...

By: TheBalancingAct

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BA2762: The Balancing Act on Lifetime Talks Organic Produce, Personalized Medicine - Video

Segway seat - AddSeat - Brake by sliding
This man has a Th 9 - Th 10 Spinal cord injury. As you can see he will need some leg support. We provide such an adjustment for this type of injury.

By: AddSeat by AddMovement

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Segway seat - AddSeat - Brake by sliding - Video