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Gene identified for sudden unexpected death in epilepsy

Story Summary: 1 has been associated with spontaneous seizures, abnormal muscle movements, and motor coordination problems. 1 because studies have shown that mice without these channels show signs of severe epilepsy and involuntary movement, and they die prematurely. Noebels and his team investigated why the mice die and whether Kv1. The results showed that the hearts of the mutated mice skipped beats intermittently. When the mice had epileptic seizures, their heart beats became even more erratic — suggesting the signals from their brains to their hearts were disordered. The researchers determined that in healthy animals these specific potassium channels are present in the brain and the vagus nerve, a bundle of axons that helps regulate cardiac rhythms, but are barely detectable in the heart. In the mutant mice, the brain signals sent to the heart through the vagus nerve were crippled. 1 channels, we think the vagus nerve loses control and sends extra nerve impulses to the heart, telling it to slow down — and even stop beating — when it shouldnt, said Edward Glasscock, PhD, first author of the study. Such progress would be very important given that SUDEP accounts for a high proportion of deaths in epilepsy patients….Read the Full Story

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  1. Catastrophic Epilepsy Caused By Single Gene Mutation
  2. Single gene mutation responsible for catastrophic epilepsy
  3. Catastrophic Epilepsy Caused By Single Gene Mutation


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NextBio Capabilities Expanded to Enable Integration and Mining of Array and Next-Generation Sequencing Data

Story Summary: The highlights of NextBio Enterprise platform include: A Software-as-a-Service (SaaS) enterprise solution enabling global research teams to capture and mine a consolidated collection of internal and public genomic data. Integration, correlation and meta-analysis of Gene Expression, Proteomics, Epigenetics, Resequencing, CNV and GWAS data. This presentation, Integrative Biological Analysis of Public and Proprietary Microarray, GWAS and Next-Gen Sequencing Data will be delivered at 12 noon ET as part of the Track 3 Session (Bioinformatics and Next-Gen Sequencing Data). NextBio will also demonstrate its research platform, including the new capabilities for mining high throughput array and Next-Gen sequencing data, at the companys exhibition hall booth, #328. We invite you to witness for yourself the knowledge-generating power of NextBio. About NextBioNextBio is the provider of an innovative platform that enables life science researchers to search, discover, and share knowledge locked within public and proprietary data. NextBios platform seamlessly combines powerful tools with unique correlated content to transform information into knowledge, providing the foundation for new scientific discoveries. NextBios unique correlation engine pre-computes billions of significant connections among public and private data and enables researchers to intelligently mine it in real-time. NextBio helps organizations increase productivity and dramatically improve collaboration across therapeutic groups and geographic boundaries….Read the Full Story

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  1. Next-Generation DNA Sequencing Raises The Bar In Laboratory Data Management | The New Computing Pioneers | Cover Story | Chemical & Engineering News
  2. BGI Selects Agilent Technologies to Streamline Next-Generation Sequencing Workflow
  3. Agilent Technologies Introduces High Sensitivity DNA Kit Targeting DNA, DNA Libraries in Next Generation Sequencing Workflow


Recommendation and review posted by Bethany Smith

CRi Imaging Technology Enables Biomarker Analysis of Cancer Drugs with Skin Biopsies

Story Summary: The researchers used the CRi Nuance FX system to conduct multiplex analyses of phosphorylated CDC2 and total CDC2 protein. Of the tissues studied, the epidermis was most consistently evaluable across the skin biopsies and demonstrated strong induction of CDC2 phosphorylation. Increases in pCDC2 were also observed for hair follicles and bulbs, but these tissues were present in fewer biopsies than epidermis, limiting the number of informative specimens. The study is entitled A phase 1b study to evaluate induction of pCDC2 in skin biopsies from patients with solid tumors treated with DNA-damaging chemotherapy. CRis patented systems enable researchers and clinicians to quantitate multiple disease and drug response markers in intact tissue samples, at a cellular level or in living small animals. CRis products integrate a unique multispectral imaging technology with proprietary image analysis algorithms to achieve unparalleled accuracy and sensitivity, rapidly and cost-effectively….Read the Full Story

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  1. CRi Launches Advanced Tissue Image Analysis Software
  2. PR-USA.net – Epistem Presents Further Data Supporting Its Plucked Hair Biomarker Technology at the Institute of C
  3. Study links virus to some cases of common skin cancer


Recommendation and review posted by Bethany Smith

Vicious circle offers new acute leukemia treatment target

Story Summary: The findings suggest a new strategy for treating acute myeloid leukemia (AML), one that targets this molecular network and lowers the amount of a protein called KIT, say researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) who conducted the study. Published in the April 13 issue of the journal Cancer Cell,the study described a new network of protein and microRNA molecules that, when imbalanced, contributes to abnormal KIT protein abundance and favors leukemia development. Using laboratory-grown AML cells, the researchers identified the series of molecules that control the amount of KIT protein, showing for the first time that a microRNA called miR-29b, along with several well-known cancer-related genes, regulate KIT production. That normal balance is derailed when gene mutations or other genetic damage occurs in the network and promotes the overproduction of the KIT protein. It becomes a vicious circle because no matter where genetic damage occurs, the result is the same – overactivation of the circle, overexpression of the KIT protein, and proliferation of leukemic cells, Liu says. Using a mouse model, the researchers showed that raising the amount of mutated KIT protein causes leukemia, and drugs that target the network lower the amount of that protein and drive the leukemia into remission….Read the Full Story

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  1. New Acute Leukemia Treatment Target Offered By Vicious Circle
  2. A miR boost enables acute leukemia cells to mature
  3. New tools for prediction of disease progression in acute childhood leukemia


Recommendation and review posted by Bethany Smith

NanoBioA(r) Launches Development Program for a Therapeutic Intranasal Vaccine for the Treatment of Hepatitis B

Story Summary: NanoBio and the University of Michigans, Michigan Nanotechnology Institute for Medicine and Biological Sciences received funding through a Phase 1 Technology Transfer (STTR) award by the National Institutes of Health (NIH), to evaluate a potential therapeutic intranasal vaccine for the treatment of hepatitis B in patients. This development program represents the first of several potential therapeutic vaccines in a significant extension of NanoBios vaccine platform. Today, vaccinations are routinely given to infants to prevent infection contributing to lower rates of incidence in recent years. The companys NanoStat adjuvant platform technology has demonstrated numerous potential advantages over traditional vaccines, including: the ability to generate robust mucosal, systemic and cellular immunity; antigen-sparing qualities; cross-protection against non-vaccinated strains; ability to adjuvant multiple antigen types without inducing inflammation; thermally stabilizing the vaccine; and removing the need for needles. About NanoBioNanoBio Corporation is a privately held biopharmaceutical company focused on developing and commercializing dermatological products, anti-infective treatments and intranasal vaccines derived from its patented NanoStat technology platform. The companys lead product candidates are treatments for herpes labialis (licensed to GSK in the U. S. and Canada), onychomycosis, acne, cystic fibrosis and a broad platform of intranasal vaccines….Read the Full Story

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  2. NanoBio and the University of Michigan to Receive $9.3M from the NIH for Nanoemulsion-Based Vaccine Development
  3. Nobilon Advances Intranasal Seasonal Influenza Vaccine Into Proof of Concept Study


Recommendation and review posted by Bethany Smith

Brand new species of bacterium found in Sweden

Story Summary: Brand new species of bacterium found in SwedenApril 19, 2010 The unique Xenoturbella, found only in the Gullmarsfjord, is the host for the new bacterium. Credit: Mattias Obst, University of GothenburgResearchers at the Sven Loven Centre for Marine Sciences at the University of Gothenburg, Sweden, have discovered a brand new species of bacterium found only in the Gullmarsfjord north of Gothenburg. The bacterium has been named Endoxenoturbella loveniito honour the newly founded marine research center. This unique creature is invaluable for studies of the early evolution of the animal kingdom, and has drawn researchers from all over the world to the Sven Loven Centre for Marine Sciences in Kristineberg ever since it was discovered. This is the conclusion of researchers at the University of Gothenburg, Sweden, who have used DNA analyses to discover that one of our . . . The lower pH may strike a severe blow to the ability of marine species to reproduce, according to research on sea urchins . . . Start of evolution22 hours ago I was just wondering where we agree that evolution began. I heard it was from the firtst single cell organism but that does not make sense as the organism must have already been evloving with it. non viral gene therapyApr 15, 2010 I was just wondering is non viral gene therapy effective enough; and in what cases/when would it be effective/non effective enough thanksWhy use bacterial DNA in recombinant DNA tech?Apr 13, 2010 What makes it suitable for the technology? The study appears in the April 19 issue of the Journal of Cell Biology. Even limited amounts of control will be extremely difficult, and right now the best . . ….Read the Full Story

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  1. MSU scientists find bacterium can halt dengue virus transmission
  2. Fossil finger points to new human species
  3. Baltimore Science News Examiner: Russell Brand and how future addiction treatments could target genes


Recommendation and review posted by Bethany Smith

Mutation effects often depend on genetic milieu

Story Summary: The genetic background of the Oregon R (center) and Samarkand (right) strains was the main determining factor in how the mutation affected the wing shape. The genetic differences that make each individual unique may be even more important than scientists previously thought, a new study of fruit flies suggests. The Oregon R strain is often used in genetic experiments, while Samarkand-strain flies are common research subjects for evolution and ecology experiments. The rest of the mutations had the same effect in both strains. This places a number on the importance of genetic diversity, says David Angelini, a developmental geneticist at American University in Washington, D. C. But the magnitude of the effect may vary from species to species, he says. Genetic diversity is going to be important in all organisms. Exactly what the number will be, I dont know, Angelini says. What it might mean is that we are some missing some players in these interactions….Read the Full Story

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  1. Newswise Medical News | Study Offers First Look at Effects of Genetic Copy Number Variation on Volatile Anesthetics
  2. Study: Love at first sight might be genetic
  3. Genetic effects suggest FOXP2 role in language evolution


Recommendation and review posted by Bethany Smith

Scientists find chicken antibodies may help prevent H5N1 pandemic

Story Summary: A team of scientists led by Dr. Huan Huu Nguyen at the International Vaccine Institute (IVI) and those at the U. S. Centers for Disease Control and Preventiontested the efficacy of the avian antibodies against both influenza viruses H5N1 and H1N1 in mice. Chicken antibodies found in egg yolk had been used mainly for treatment of gastrointestinal infections. The chicken antibodies could be administered as a nasal spray. This is a very exciting project that could be carried out with materials produced in the developing world in the absence of a highly complex infrastructure. A study published today in the open access journal Respiratory Research reveals that a dose of 100 . . . Yet public health experts agree that the current method of growing seasonal influenza vaccines in chicken eggs is slow and inefficient. Protein Powder22 hours ago A biochemistry major said protein powder is bad for you but never gave the reasons, so I was disappointed in that. Water content of the human bodyApr 15, 2010 I was wondering how the total amount of water in a typical human varies by weight and sex. free associationApr 15, 2010 NootropicsApr 14, 2010 Hi, just wondering does anyone know anything about these? For those who dont know, theyre drugs (legal, they come under the category of suppliements) that are supposed to improve cognitive power,. In a worst case scenario, disruption of this proteins function can lead to cardiac arrest, which . . . 6 minutes ago | not rated yet | 0 New immigrants, especially women and those of South Asian or African descent, have a higher risk of diabetes compared with long-term residents of Ontario, found a research study in CMAJ (Canadian Medical Association Journal)….Read the Full Story

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Recommendation and review posted by Bethany Smith

New insight into Parkinsons disease

Story Summary: New insight into Parkinsons diseaseApril 19, 2010 New research provides crucial insight into the pathogenic mechanisms of Parkinsons disease (PD), a prevalent neurodegenerative disorder. The study appears in the April 19 issue of the Journal of Cell Biology. The identification of inherited mutations in genes such as Parkin and PINK1 ( PTEN-induced putative kinase 1 ) has revealed key factors in the development of familial forms of the disease. Parkin adds ubiquitin molecules to other proteins to trigger their degradation, while PINK1 regulates mitochondrial quality control. Furthermore, PINK1 recruits Parkin from the cytoplasm to mitochondria with low membrane potential to initiate the disposal of damaged mitochondria. Interestingly, the ubiquitin ligase activity of Parkin is repressed in the cytoplasm under steady-state conditions; however, PINK1-dependent mitochondrial localization liberates the latent enzymatic activity of Parkin. The mechanisms leading to the loss of these neurons, however, are largely unknown. As reported in the Journal of Neuroscience, the protein activates a survival mechanism which had been known for its prominent role in imm . . . It is also known that mutations in a protein called parkin cause a form of Parkinsons that is inherited. I heard it was from the firtst single cell organism but that does not make sense as the organism must have already been evloving with it. non viral gene therapyApr 15, 2010 I was just wondering is non viral gene therapy effective enough; and in what cases/when would it be effective/non effective enough thanksWhy use bacterial DNA in recombinant DNA tech?Apr 13, 2010 What makes it suitable for the technology? Even limited amounts of control will be extremely difficult, and right now the best . . . 2 hours ago | not rated yet | 0 The fifth Howler Monkey census at the Smithsonians Barro Colorado Island research station in Panama, organized by Katie Milton, professor in the department of Environmental Science, Policy & Management at . . . 2 hours ago | not rated yet | 0 The fifth Howler Monkey census at the Smithsonians Barro Colorado Island research station in Panama, organized by Katie Milton, professor in the department of Environmental Science, Policy & Management at . . . 2 hours ago | not rated yet | 0 The fifth Howler Monkey census at the Smithsonians Barro Colorado Island research station in Panama, organized by Katie Milton, professor in the department of Environmental Science, Policy & Management at . . ….Read the Full Story

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  1. Nerve Cells In Parkinsons Disease Suffer Communication Breakdown
  2. When cells run out of fuel
  3. When Cells Run Out Of Fuel Parkinson Genes Ensure The Energy Supply Of Neurons


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First Direct Recording of Mirror Neurons in Human Brain

Story Summary: Further, they showed that specific subsets of mirror cells increased their activity during the execution of an action but decreased their activity when an action was only being observed. The researchers drew their data directly from the brains of 21 patients who were being treated at Ronald Reagan UCLA Medical Center for intractable epilepsy. The patients had been implanted with intracranial depth electrodes to identify seizure foci for potential surgical treatment. Electrode location was based solely on clinical criteria; the researchers, with the patients consent, used the same electrodes to piggyback their research. In the activity phase, the subjects were asked to perform an action based on a visually presented word. The researchers found that the neurons fired or showed their greatest activity both when the individual performed a task and when they observed a task. This new finding demonstrates that mirror neurons are located in more areas of the human brain than previously thought. Given that different brain areas implement different functions — in this case, the medial frontal cortex for movement selection and the medial temporal cortex for memory — the finding also suggests that mirror neurons provide a complex and rich mirroring of the actions of other people. Given that different brain areas implement different functions — in this case, the medial frontal cortex for movement selection and the medial temporal cortex for memory — the finding also suggests that mirror neurons provide a complex and rich mirroring of the actions of other people….Read the Full Story

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  2. Neurons play Simon Says
  3. Human Brain Can Control Single Celebrity-Recognizing Neurons


Recommendation and review posted by Bethany Smith

GEN reports on the promise of DNA vaccines

Story Summary: GEN reports on the promise of DNA vaccinesApril 19, 2010 Laboratory research and clinical studies are beginning to demonstrate that DNA vaccines can be as effective as traditional vaccines, reports Genetic Engineering & Biotechnology News (GEN). A number of factors are driving the growth of the field, especially new approaches to electroporation, vaccine formulation, and vector design, according to the April 15 issue of GEN. A lot of development is focused on the creation of DNA vaccines for humans, says John Sterling, Editor in Chief of GEN. Many of the advances being made are due to the introduction of new technologies and improvements in older methodologies. For example, scientists at the Karolinska Institute and Tripep are working on a therapeutic vaccine for hepatitis C virus. Inovio Biomedical, in particular, has aggressively pursued development of a minimally invasive electroporation device. In addition, Althea Technologies has developed a high cell density fermentation and purification process for plasmid DNA products that reportedly provides plasmid yields in the range of 100-2,000 mg/L depending on plasmid size and bacterial strain. Protein Powder22 hours ago A biochemistry major said protein powder is bad for you but never gave the reasons, so I was disappointed in that. Water content of the human bodyApr 15, 2010 I was wondering how the total amount of water in a typical human varies by weight and sex. free associationApr 15, 2010 NootropicsApr 14, 2010 Hi, just wondering does anyone know anything about these? For those who dont know, theyre drugs (legal, they come under the category of suppliements) that are supposed to improve cognitive power,. More from Physics Forums – Medical Sciences56 minutes ago | not rated yet | 0 Researchers have discovered a new disorder linked to heart problems that stems from a genetic defect in the protein glycogenin. In a worst case scenario, disruption of this proteins function can lead to cardiac arrest, which . . . In a worst case scenario, disruption of this proteins function can lead to cardiac arrest, which . . . 36 minutes ago | not rated yet | 0 A substance found in breast milk can kill cancer cells, reveal studies carried out by researchers at Lund University and the University of Gothenburg, Sweden….Read the Full Story

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Recommendation and review posted by Bethany Smith

Scrubbing IDs Out of Medical Records for Genetic Studies

Story Summary: But if that asthmatic patient also had a broken arm as a teenager, the algorithm changes the medical code for a broken left forearm to a code that indicates only a broken bone. The team assumed a hacker might know a patients identity, some of their medical history and maybe some of the medical codes associated with that history. The technique stymied efforts to ID an individual based on that information, the researchers report. There is definitely a need to de-identify individuals, says Homer, who was part of a team that demonstrated two years ago that it is possible to trace a genetic signature back to an individual even when that persons DNA profile was buried in a pool of thousands. Establishing such links could help doctors understand, for example, why patients respond differently to certain drugs. See Also:Comments (2)Not a member?If youre not yet registered with Wired. com, join now so you can share your thoughts and opinions. Your username and password will be sent to the e-mail address you provided usHoliday Cars Car Rental– Search the lowest priceRental Car- On-Line Confirmation {150 Countries = 19000 Locations}Quick Confirm Next Day Rooms & Safely Pay Hotel Only On Check-out!This is re-inventing the wheel. Use of EHR data for genetic/pharma/epidemiology research is a special case of so-called secondary use….Read the Full Story

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Recommendation and review posted by Bethany Smith

TAU Is Bioengineering Tissues As An Alternative To Animal Testing

Story Summary: A more efficient road to scientific researchBridging the worlds of biology and engineering, Prof. Gefen is now using adult rat stem cells- cells that can be stimulated to create skin, bone, fat and muscle tissue from an animal in a laboratory setting. When an experiment is over, not one animal life has been lost. The use of engineered tissues, says Prof. Gefen, may also be more scientifically efficient than using those from a living source. Our tools spare an enormous number of lives, Prof. Gefen says. He is also developing a new tool for researchers to investigate fat accumulation in cells (an important question for diabetesresearchers) and weight loss drugs. Another measures how much sensation is left in a diabetic limb. For all these approaches, Prof. Gefen has adopted tissue engineering methods to use fewer animals in his trials. Source: George HunkaAmerican Friends of Tel Aviv University Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. Simply click the link below and select the follow option. When Your Cycle Becomes a Major HeadacheCathys gets as many as 12 to 15 headaches a month and they are all associated with her menstrual cycle. Migraines like hers tend to last longer and be more severe than other migraines….Read the Full Story

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  1. A lab rat — created in the lab
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Recommendation and review posted by Bethany Smith

Discovery Of Changes In Fetal Epigenetics Throughout Pregnancy May Help In Diagnosis And Prevention Of Complications

Story Summary: In healthy fetal development, one copy of these genes is normally active and the other copy is silent. The surprising results showed that more LOI occurred in the first trimester than at full term. Dr. Lee and her team concluded that genomic imprinting appears to be an ever-changing process in the placenta, meaning that pregnancy risks can change throughout the course of gestation. Previously, the medical community believed imprints remained static after 12 weeks. Now that we know the epigenetic make-up in the placenta changes during the course of a pregnancy, we can develop biomarkers to see if those pregnancies destined to develop preeclampsia or fetal growth restriction can be detected early enough in pregnancy to allow prevention of these diseases. An estimated 10 percent of pregnancies are complicated by fetal growth restriction, which increases the risk of stillbirth, cerebral palsy, feeding intolerance, and failure to thrive. More research is necessary to determine the impact of this discovery on potentially reducing the risk of other serious conditions like autism, cancer, and childhood obesity, said Dr. Lee. Contact Our News EditorsFor any corrections of factual information, or to contact the editors please use our feedback form….Read the Full Story

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Recommendation and review posted by Bethany Smith

Anonymizing patient records for genomics

Story Summary: There is a huge push under way in the United States and elsewhere to create and exploit electronic medical records (see Clinical epidemiology: Archived answers). There are lots of different types of information that exist within medical records. In the past it has been shown that demographic information is readily linkable to public information that could lead to the identification of patients. That could allow someone such as a hospital employee to identify them, even if the patients name and other identifying information have been removed. To solve this problem, the new method allows researchers to set two parameters: the minimum number of patients () that should have the same set of codes, and a utility policy which specifies how codes should be linked in the anonymized data. If in the original data only Patient X has type 1 and only Patient Y has type 2, the system will anonymize the data by making both patients have the codes for both types. However, the data will still allow researchers to identify people with diabetes. If it is adopted, he says, researchers would have access to significantly greater amounts of data than they currently have. The paper addresses an important issue related to potential for re-identification from electronic medical record data used for genome-wide association studies, says Teri Manolio, director of the Office of Population Genomics at the NHGRI. She adds that the best insurance against unintended re-identification are the agreements that bind researchers to ethical use of the data. Genome wide association studies and whole-genome sequencing is by itself very sensitive data — with or without the electronic medical record data being anonymized, says Thomas Hudson, a member of the International Cancer Genome Consortium executive and president of the Ontario Institute for Cancer Research in Toronto. Hudson plans to bring the new research to the attention of ethics and data-access groups of the International Cancer Genome Consortium. This is a hot issue, which we need to understand from multiple perspectives — informatics, legal, societal, ethical — that may differ in different parts of the world, he says. #10089Thank You,Public healthcare or not demographics and expectations will skyrocket in the decades to come. You need to be registered with Nature to leave a comment….Read the Full Story

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Recommendation and review posted by Bethany Smith

Scientists Find Gene Fault Behind Aggressive Ovarian Cancer

Story Summary: These results also show for the first time that these aggressive ovarian cancers have the highest known rate of TP53 mutations of any solid tumour. The TP53 gene codes for a protein called p53, which in normal cells is activated in response to cell damage and one of its functions is to order cells to die when DNA damage is beyond repair. Its critical that p53 functions normally to prevent genetic mistakes from accumulating in cells, which can lead to cancer. The p53 protein is missing or faulty in the majority of cancers. Dr Helen George, head of science information at Cancer Research UK, said: These really important laboratory findings could have a significant impact for ovarian cancer patients in the future. Cancer Research UK scientists co-discovered the p53 protein around 30 years ago. More than half of diagnosed cases of epithelial ovarian cancer are of the serous type 2. Please send any medical news or health news press releases to: These are the most read articles from this news category for the last 6 months: Discovery Of Switch That Turns On The Spread Of Cancer15 Feb 2010Reporting in Nature Cell Biology, researchers describe the discovery of a specific protein called disabled-2 (Dab2) that switches on the process that releases cancer cells from the original tumor and allows the cells to. Follow Our News On Twitter:Get the latest news for this category delivered straight to your Twitter account….Read the Full Story

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Recommendation and review posted by Bethany Smith

New Acute Leukemia Treatment Target Offered By Vicious Circle

Story Summary: Our study suggests that the amount of KIT protein in cancercells is as important as its activity, and we discovered that the amount of the protein is controlled by a circular network of molecules that has many points of entry, says senior co-leader Dr. Ramiro Garzon, assistant professor of internal medicine and an AML specialist at the OSUCCC-James. These findings provide a strong rationale for the use and development of drugs that target the components of this network rather than focusing on the activity of KIT alone. Marcucci, Garzon, first author Shujun Liu, assistant professor of internal medicine, and their colleagues began this study by showing that patients with mutations in the KIT gene in their leukemic cells had the highest levels of the KIT protein in those cells, and that these patients also had the poorest survival. That normal balance is derailed when gene mutations or other genetic damage occurs in the network and promotes the overproduction of the KIT protein. Using a mouse model, the researchers showed that raising the amount of mutated KIT protein causes leukemia, and drugs that target the network lower the amount of that protein and drive the leukemia into remission. Funding from the National Cancer Institute, the Harry T. Mangurian Jr. Foundation Leukemia Research Fund, the Coleman Leukemia Research Foundation, the Sidney Kimmel Cancer Research Foundation, and the Deutsche Krebshilfe (Dr. Mildred Scheel Foundation for Cancer Research) supported this research. Other Ohio State researchers involved in this study were Lai-Chu Wu, Jiuxia Pang, Ramasamy Santhanam, Sebastian Schwind, Yue-Zhong Wu, Christopher Hickey, Jianhua Yu, Heiko Becker, Kati Maharry, Michael D. Radmacher, Chenglong Li, Susan P. Whitman, Anjali Mishra, Nicole Stauffer, Anna M. Eiring, Roger Briesewitz, Robert A. Baiocchi, Kenneth K. Chan, Michael A. Caligiuri, John C. Byrd, Carlo M. Croce, Clara D. Bloomfield and Danilo Perrotti. Follow Our News On Twitter:Get the latest news for this category delivered straight to your Twitter account. Simply click the link below and select the follow option. Monitoring and Adherence in CMLImatinib, or Gleevec, is a targeted anti-cancer drug that can keep chronic myelogenous leukemia (CML) in check for most patients for many years. It is important for patients to take imatinib as prescribed by their doctor to fight the disease and to guard against resistance….Read the Full Story

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Recommendation and review posted by Bethany Smith

Lab-animal battle reaches truce

Story Summary: Basic research using primates will now be allowed, for example, and animals will not have to be destroyed immediately after research procedures that cause moderate discomfort, as previous forms of the directive had decreed. It is a political document, a compromise text, says Stefan Treue, director of the German Primate Centre in Gottingen. But it could have been worse and we can live with it. The compromise that has been reached is something we can live with, agrees Kirsty Reid of the Brussels-based animal-welfare lobby group Eurogroup for Animals, adding that she still regrets the many exemptions to bans on several types of research. For example, it banned research on non-human primates unless it was directly applicable to the treatment of life-threatening or debilitating human conditions, thus blocking basic research, particularly on the brain. And in insisting that animals be destroyed after an experiment causing mild discomfort, it would have dramatically increased the number of animals used in research. Instead, he claims, the commission was exposed to the emotionally powerful influence of the well-organized animal-welfare and anti-vivisection lobby. But in 2009, research organizations swung into action to persuade parliament to be more sympathetic to their point of view. After a new parliament was elected last June, the animal-welfare lobby pounced on new members, convincing many to argue for further restrictions, says Julian Bocker, parliamentary assistant to directive rapporteur Elisabeth Jeggle. Id like to be able to convey just how hard we had to fight to maintain research-friendliness in the directive, says Bocker. The directive does ban some forms of research — those involving great apes or causing extreme and prolonged pain. The final draft of the directive also allows experiments on endangered species, such as the barn owl (), which is bred in captivity specifically for auditory research. Procedures for project applications and evaluations are more streamlined than in earlier drafts, and the bureaucratic burden should not increase for researchers from countries in which rules are already strict, such as Britain, Germany and France. Others maintain that an outright ban on some types of studies clashes with Europes constitutional duty to carry out research, as enshrined in the Lisbon Treaty, adopted in December 2009. You can be controversial, but please dont get personal or offensive and do keep it brief. Please log in or register as a new user. Please log in or register as a new user….Read the Full Story

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Recommendation and review posted by Bethany Smith

High Red Meat Consumption Linked to Colon Cancer

NEW YORK (Reuters Health) - Long-term high consumption of red and processed meat may increase the risk of cancer in the colon and rectum, a new study shows.

Dr. Michael J. Thun, with the American Cancer Society in Atlanta, and colleagues followed 148,610 adults, average age 63 years, who completed questionnaires in 1982 and again between 1992 and 1993 regarding their diet, exercise, medical history and other lifestyle habits.

By 2001, there were 1667 new cases of colorectal cancer, according to a report in Wednesday's Journal of the American Medical Association.

The participants who consistently ate the most red meat and processed meats had a 50 percent higher rate colorectal cancer than those who ate the least red or processed meat.

Prolonged high consumption of poultry and fish was marginally associated with about a 25 percent lower risk of colon cancer, but not rectal cancer. Read more...

Ayurtox for Body Detoxification

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Structure of inner-ear protein is key to both hearing and inherited deafness

Story Summary: The ciliatip link apparatus in the hair cell is a clever arrangement of spring-like and string-like protein molecules, yet their atomic structures and mechanical properties are not well known. Furthermore, they found that many mutations to cadherin-23 cause inherited deafness by weakening the ability of calcium to hold the protein together. Our findings help explain a whole class of inherited deafness, says Corey. Through crystallization, the researchers found that, like other members of the cadherin family, this protein contains three critical calcium ions between each of its 27 bead-like segments. In addition, a novel calcium-ion binding site was discovered at the very end of cadherin-23. To quantify exactly how strong these calcium-ion bonds were, the scientists loaded the proteins structure into a supercomputer, rendered its virtual likeness, then stretched the structure. They found that overall the protein acted more like a wire cable than a spring, as previously thought. With simulations, we could test both structures elasticity and reactions to force. The researchers found that some mutations reduced the ability of the protein to bind calcium ions. This research was funded by the National Institutes of Health, National Science Foundation, U. S. Department of Energy, Klingenstein Fellowship AwardCITATION: Neuron,April 15, 2010, Vol. 1Structural Determinants of Cadherin-23 Function in Hearing and Deafness Marcos Sotomayer (1, 3, 4), Wilhelm A. Weihofen (2, 4), Rachelle Gaudet (2), David P. Corey (1, 3) (1) Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 (2) Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138 (3) Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815 (4) Co-first authorsHarvard Medical School has more than 7,500 full-time faculty working in 11 academic departments located at the Schools Boston campus or in one of 47 hospital-based clinical departments at 17 Harvard-affiliated teaching hospitals and research institutes….Read the Full Story

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  1. Genetic Cause For Type Of Deafness Identified; Discovery Could Lead To New Therapies For Progressive Hearing Loss
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  3. Scripps research scientists identify genetic cause for type of deafness


Recommendation and review posted by Bethany Smith

Risk Of Crohns Disease And Genetic Variants

Story Summary: Surprisingly, we found no statistically significant association between NOD2/CARD15 genetic variants and Crohn disease in either of the two general population studies that we analyzed, which suggests a low penetrance of the genetic variants in the European general population, write Dr. Borge G. Nordestgaard, Herlev Hospital, University of Copenhagen, Denmark and coauthors. This should be considered when advising healthy individuals in whom these genetic variants are discovered. In a related commentary, Dr. Katherine A. Siminovitch and coauthors write that these research findings reinforce the fact that common diseases have many causes and that in these diseases, the effect of any single gene variant on risk is usually small. This underscores the current challenge in realizing the potential of personalized medicine (use of an individuals specific information to select or optimize preventive care and therapy). Please send any medical news or health news press releases to: These are the most read articles from this news category for the last 6 months: Sufferers Of Crohns Disease May Benefit From Vitamin D Supplements29 Jan 2010A new study has found that Vitamin D, readily available in supplements or cod liver oil, can counter the effects of Crohns disease. Follow Our News On Twitter:Get the latest news for this category delivered straight to your Twitter account….Read the Full Story

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Recommendation and review posted by Bethany Smith

UDs Zhuang wins NSF Early Career Award for research on how cells bypass damaged DNA

Story Summary: Zhihao Zhuang, assistant professor in the Department of Chemistry and Biochemistry at the University of Delaware, has won the National Science Foundation (NSF) Faculty Early Career Development Award. It is NSFs most prestigious award in support of faculty early in their careers who exemplify the role of teacher-scholars through outstanding research, excellent education, and the integration of education and research within the context of the mission of their organizations. What we learn from the model system, S. cerevisiae, has important implications for the human system because many of the DNA transaction pathways in both organisms are conserved, Zhuang notes. The ultimate goal of the project, Zhuang notes, is to establish research and educational programs that not only advance the field of chemical biology by enhancing the scientific understanding of DNA damage tolerance, but also to inspire and educate the next generation of chemical biologists. The projects outreach component seeks to spark the scientific curiosity and career aspirations of high-school students, with particular emphasis on underrepresented minorities in chemistry and biology, through the virtual reality visualization system called the CAVE at the Delaware Biotechnology Institute. High-school students will be able to walk into the larger-than-life 3-D structures of the specialized DNA polymerases that we are studying to see the variations in geometry of the active site as well as the DNA binding groove. Im very excited and honored to receive this award, Zhuang says. There are currently five graduate students and one postdoctoral fellow working in Zhuangs laboratory. A new method for producing ubiquitylated proteins developed by Zhuang and his group recently was reported in the prestigious journal Nature Chemical Biology. Zhuang also recently won a Delaware Health Sciences Alliance (DHSA) pilot project grant for research to discover inhibitors that can lead to the development of potent, new anti-cancer drugs. Zhuang received his bachelor of science degree in chemistry from Sichuan University in China and his doctorate from the University of New Mexico….Read the Full Story

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Recommendation and review posted by Bethany Smith

Antidepressants As Treatment Immediately Following A Stroke?

Story Summary: Kunlin Jin, Xiaomei Wang, Lin Xie and Xiao Mao, showed that the brain attempts to heal itself following stroke by growing new neurons, but it has not been shown clearly that those new neurons improve function. Clot busting drugs, which have to be given within hours of the stroke, have been of great benefit to a small number of patients, but stroke is not usually diagnosed in time for them to be used. Building on the Institutes collaborative approach to research involving other age-related disorders, Greenberg says its also likely that the impact of the growth of new neurons will be examined in animal models of Alzheimers, Parkinsons and Huntingtons disease. He says those suffering from stroke should not treat themselves, even with FDA-approved drugs, without medical advice. Even taking something as seemingly innocuous as an antidepressant carries the possibility of making someone worse. These drugs need to be tested in a controlled clinical setting. Follow Our News On Twitter:Get the latest news for this category delivered straight to your Twitter account. Simply click the link below and select the follow option. But many of the 11 million Americans that have both conditions dont get the treatment they need. Keeping a Personal Medical RecordMedical information is usually scattered in many different places. To receive the best possible health care, people are encouraged to gather information in one place and create a personal medical record….Read the Full Story

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Recommendation and review posted by Bethany Smith

2 Hopkins scientists awarded European honorary doctorates

Story Summary: The Board of Research of Karolinska stated, Professor Feinbergs work saves lives and he personally encourages other researchers to push the boundaries of knowledge in biology and medicine. The various members of the TRP family of proteins have transformed our understanding about how animals, ranging from insects to humans, detect a broad array of sensory stimuli. Recently, the Montell group revealed the cellular mechanism underlying an early childhood neurodegenerative disease, mucolipidosis type IV, providing a novel strategy for treating this disease. The research community at Johns Hopkins is proud that both Andy and Craig have received such honors, says Stephen Desiderio, M. D. , Ph. Situated in the heart of Western Europe, the Katholieke Universiteit Leuven was founded in 1425 by Pope Martin V and is the oldest existing Catholic university in the world. Previous recipients of Leuvens honorary degree include Nobel Prize-winning scientists, religious pioneers and noteworthy politicians, including Louis Pasteur, Alexander Fleming, Christian de Duve, Charles De Gaulle, Winston Churchill and Dwight Eisenhower….Read the Full Story

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Recommendation and review posted by Bethany Smith

Hopkins Researchers Put Proteins Right Where They Want Them-4/14/10

Story Summary: Their research, published Feb. 14 in Nature Methods,expands on a more limited method using a chemical tool to move proteins inside of cells to the periphery, a locale known as the plasma membrane. Where a particular protein is activated and the timing of that activation influence how a cell responds to outside stimulus, says Takanari Inoue, Ph. Chemical signaling inside cells connects protein molecules through complex feedback loops and crosstalk, Inoue says, so knowing exactly how each protein contributes to which signals at what locations requires the ability to rapidly move proteins of interest to specific organelles found in cells. They cut out the mailing address — known as a targeting sequence — that formerly delivered the protein unit to the plasma membrane and replaced it with new addresses (targeting sequences) that shipped it instead to specific organelles. We were able to manipulate protein activities in situ and very rapidly on each individual organelle, Inoue said. Ultimately, this will help us to better understand protein function at these critical cellular components….Read the Full Story

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Recommendation and review posted by Bethany Smith


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