Archive for the ‘Hormone Clinic’ Category
Twenty years ago if you wanted to be laughed out of town, you would have written a book titled: “Eat Lots of Fat and Lose Weight.” If you were a doctor and the author of that book you would have risked professional ridicule.
At the end of 2016, Mark Hyman, MD’s “Eat Fat, Get Thin,” was published by Little, Brown and Company and it became a New York Times best seller. The only chuckle heard was the IRS giggling all the way to the U.S. Treasury.
Hyman is the director of the Cleveland Clinic Center for Functional Medicine.
In his new book, Hyman explores the biggest myth: When it comes to weight gain or loss, it’s a calories-in, calories-out world. He says that’s simply not true. The key to weight loss or gain is how different calorie sources are metabolized. Essentially, eating Hyman’s way, you can stop counting calories.
Hyman makes it clear, backing it up with studies, that our bodies process sugars or highly processed carbohydrate calories differently from a protein calorie or a fat calorie.
He writes: “When taken as a whole, the science shows us a clear pattern of evidence that carbs make you fat, while fat makes you thin.” The complete opposite of the decades-long mantra we’ve all been chanting.
Hyman’s book, “Eat Fat, Get Thin,” explains that all that science backs up what he believes is a food plan that can lead to healthy weight loss and maintenance. He is not just the living example of that truth; he’s treated more than 20,000 patients who also appear to be true believers.
Hyman’s a huge coconut oil fan thanks to its medium-chain triglycerides and explains why some of the saturated fats that make up coconut oil can and do promote health.
He also likes olive oil; not so much for cooking, more for salad dressings and for making homemade mayonnaise (yes, he’s got a recipe for that).
Hyman’s no fan of trans fat (partially hydrogenated oil). For reasons too long to list here, his best advice: stay as far away from trans fats as possible.
Hyman recommends a blend of the best of vegan and Paleo that he (unfortunately) calls Pegan.
Here’s an abridged list of what Hyman likes in his food plan: organic, local, fresh whole foods (high in vegetables and fruits); low or no pesticides, antibiotics, or hormones; very few or no chemicals; higher in quality fats (like olive oil and avocados). The plan is low in refined, processed vegetable oils (say goodbye to canola and soybean oils); moderate amounts of protein; animal food (from humanely and sustainably raised, antibiotic and hormone free sources); fish (of course low-toxin, like sardines or anchovies).
Hyman shuns dairy, but, no surprise, he’s big on veggies. He lists 43 vegetables to eat in virtually unlimited quantities, such as artichokes, asparagus, bell peppers, broccoli, cabbage, carrots, eggplant, fennel, green beans, kale, lettuce, mushrooms, onions, snap peas, summer squash and tomatoes. Potatoes aren’t on that list.
Select fruits work; Hyman’s favorites are the berries (except for strawberries) like frozen blackberries, wild blueberries and raspberries, along with kiwi, pomegranate and watermelon. Oranges, bananas or grapes, all of which are high in natural sugars, are absent from that list.
There’s a lot to learn about Hyman’s food plan. Read all about it in “Eat Fat, Get Thin” book. If you buy into his weight-loss plan, then you’ll also want to get his “Eat Fat, Get Thin Cookbook.”
It may take a while to get used to how it all works, but I believe it’ll turn out to be worth the effort.
Here’ one of Hyman’s recipe’s from his cookbook to try.
Chicken and Arugula Salad with Roasted Red Pepper Vinaigrette
4 (6-ounce) boneless, skinless chicken breasts
1/4 teaspoon freshly ground black pepper
1 teaspoon sea salt
2 tablespoons avocado oil
2 jarred roasted red peppers, patted dry
1/4 cup extra-virgin olive oil
2 tablespoons sherry vinegar
2 garlic cloves
1/2 teaspoon dried thyme
4 cups baby arugula
1 small red onion, thinly sliced
1 cup pitted Kalamata olives
2 hard-cooked eggs, peeled and quartered
Preheat the oven to 350 degrees.
Season the chicken breasts on both sides with teaspoon of salt and the pepper.
In a large oven-safe skillet, warm the avocado oil over medium-high heat until shimmering. Add the chicken breasts to the pan in a single layer and cook for 5 minutes. Flip the breasts, transfer the pan to the oven, and cook until the meat is opaque throughout and the internal temperature reaches 165 degrees on an instant-read thermometer, about 6 to 7 minutes. Transfer the chicken breasts to a cutting board and let rest for 2 to 3 minutes while you make the vinaigrette.
Combine the roasted red peppers, olive oil, vinegar, garlic, thyme and the remaining salt in a blender. Blend on high speed until smooth, about 30 seconds.
Cut the chicken breasts crosswise into -inch slices. Divide the arugula among 4 plates and top with the onion slices, olives, hard-cooked eggs, and chicken, evenly distributing the ingredients. Drizzle vinaigrette over each salad and serve.
Nutrition values per serving: 507 calories (41.4 percent from fat), 30 g fat (4 g saturated fat), 8 g carbohydrates, 2 g fiber, 32 g protein, 171 mg cholesterol, 1122 mg sodium.
— Used with permission from “The Eat Fat, Get Thin Cookbook” by Mark Hyman, MD (Little Brown, 2016).
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Healthy eating, the Hyman way – Durham Herald Sun
These transgender patients now have a place to change their lives all at once
It was the final touch on her new, true self. For everything else, the 28-year-old went to Dr. Christopher Salgado at the University of Miami, the lead surgeon at the hospital's new LGBTQ clinic. … In 2014, Medicare began covering hormone therapy and …
The CDC says about 38 percent of American adults are considered clinically obese and 71 percent are overweight. Research shows that hormone imbalance can have a huge impact on this back-and-forth weight gain. Wellness experts are seeing how balancing the hormones can help with weight loss.
In her hormone therapy clinic, Terri DeNeui says the benefits of hormone replacement therapy go beyond increased energy levels, mood and libido.
That’s what happened to Brandy Prince, a nurse practitioner, who had no energy, and a pattern of losing and gaining weight over and over.
“I was obese at 208 pounds and I felt terrible, I felt terrible about myself, I got out of bed every morning and everything just hurt,” she said.
Using pellets that are inserted under the skin, Brandy got testosterone, which helped her build muscle and her thyroid levels were increased. She slept better and she lost weight, eventually more than 50 pounds.
“So the weight loss was not something that I expected or anticipated, but it was definitely a wonderful benefit,” she said.
“It’s not just my physical size, but my entire confidence, and my self-esteem has changed. I’m not the same person,” Brandy said.
Doctors say this type of hormone therapy has minimal risk factors and few side effects, although patients with a history of breast or prostate cancer may need further evaluation and doctors may consider alternate options for those patients.
If you would like more information, check out the medical breakthroughs on the web at http://www.ivanhoe.com.
Middle-aged adults who use recreational amphetamines like “speed,” “ecstasy” or “ice” may develop a prematurely aging heart and experience health problems normally associated with older people, a recent study suggests.
People may crave the euphoric feelings produced by amphetamines, but these drugs have long been linked to heart attack, stroke, artery wall damage, bleeding in the brain, abnormal heart rhythm and sudden cardiac death, said lead study author Dr. Stuart Reece of the University of Western Australia in Crawley.
“It makes sense that all these different issues are linked by an underlying acceleration of the aging effect,” Reece said by email. “We found that the effect was very considerable indeed.”
Amphetamines are a stimulant and they send what’s known as the sympathetic nervous system, or “fight or flight” hormone adrenaline into overdrive. Previous research has linked these drugs to premature aging of the skin, and the current study suggests amphetamines might also prematurely age the heart.
For the study, researchers measured blood flow through a main artery in the upper arm and forearm for 713 people in their 30s and 40s at a clinic for substance misuse. Arteries harden with age.
Each patient was asked about drug use and placed in one of four groups: non-smokers, smokers, amphetamine users and methadone users. Methadone is a substitute for heroin given to people trying to overcome addiction to that illegal drug.
Researchers used a blood pressure cuff and monitoring system to calculate what they described as biological vascular age by matching the extent of hardening in the arteries with chronological age, gender and height.
Almost all of the 55 amphetamine users in the study had used these stimulants within the previous week, and about half had used the drugs in the previous day before doing the blood pressure cuff tests.
Even after accounting for several risk factors for cardiovascular disease such as weight, cholesterol levels and inflammation, amphetamine use was still independently associated with an “advancement” of cardiovascular age, researchers report in Heart Asia.
The accelerated aging seen with amphetamines appeared to be even more pronounced than with tobacco use and was equivalent to about a 25 percent increase over chronological age, Reece told Reuters Health. In other words, adding a decade of aging to an average 40-year-old.
Beyond the small number of amphetamine users in the study, another limitation is the lack of data on how much of the stimulants people used, the authors note.
All stimulants work by increasing dopamine levels in the brain. Dopamine is a chemical linked to pleasure, movement and attention.
Stimulants like Adderall, Ritalin and Concerta are often prescribed to children and adults diagnosed with attention deficit hyperactivity disorder in doses that are not associated with cardiovascular problems.
“At therapeutic doses, stimulant medications have been shown to be safe,” said Dr. Jose Martinez-Raga, a researcher at the University of Valencia in Spain who wasn’t involved in the study.
“Amphetamine abuse implies using these stimulant drugs over long periods of time and generally with much larger doses than those commonly prescribed for medical reasons,” Martinez-Raga added by email.
When people take amphetamines in higher doses than those typically prescribed, people can experience a rapid surge of dopamine in the brain that can trigger feelings of euphoria and increase the risk of addiction.
“No medical patient smokes or shoots their pills,” Reece said. “These high levels are very addictive, they are very damaging, and they produce great spikes in blood pressure and heart rate which are straining and damaging both for the heart itself and for the blood vessels.”
SOURCE: http://bit.ly/2lLwPUX Heart Asia, online February 9, 2017.
The hormone melatonin appears to suppress the growth of breast cancer tumors, say researchers.
While treatments based on this key discovery are still years away, the results, published in the journal Genes and Cancer, offer a foundation forfuture research.
You can watch bears in the zoo, but you only understand bear behavior by seeing them in the wild, says coauthor David Arnosti, a biochemistry professor and director of the Gene Expression in Development and Disease Initiative at Michigan State University.
Similarly, understanding the expression of genes in their natural environment reveals how they interact in disease settings.
The brain manufactures melatonin only at night to regulate sleep cycles. Epidemiologists and experimentalists have speculated that the lack of melatonin, due in part to our sleep-deprived modern society, puts women at higher risk for breast cancer.
This newstudy shows that melatonin suppresses the growth of breast cancer stem cells, providing scientific proof to support the growing body of anecdotal evidence on sleep deprivation.
Before the team could test its theory, the scientists had to grow tumors from stem cells, known as mammospheres, a method perfected in the Michigan State laboratory of James Trosko.
The growth of these mammospheres was enhanced with chemicals known to fuel tumor growth, namely, the natural hormone estrogen, and estrogen-like chemical Bisphenol A, or BPA, found in many types of plastic food packages.
Melatonin treatment significantly decreased the number and size of mammospheres when compared with the control group.
Furthermore, when the cells were stimulated by estrogen or BPA and treated with melatonin at the same time, there was a greater reduction in the number and size of mammospheres.
This work establishes the principal by which cancer stem cell growth may be regulated by natural hormones, and provides an important new technique to screen chemicals for cancer-promoting effects, as well as identify potential new drugs for use in the clinic, Trosko says.
Additional researchers at Michigan State and from the Faculdade de Medicina de Sao Jose do Rio Preto in Brazil contributed to the work.
Want to find more Breast Cancer news? Follow Knowridge Science Report onFacebook.
News source: Michigan State University. The content is edited for length and style purposes. Figure legend: This Knowridge.com image is for illustrative purposes only.
UAGADOUGOU, Burkina Faso It was after dark when awoman and her husband arrived. They crossed the dirt road and entered the cement buildingin a western neighborhood ofthis sprawling West African capital.
He had a demand: Remove the metal rodsyouve put in my wifes arm.Hed heard rumors that the strange technological device was going to give her cancer, and itneeded to go.
The nurse on duty at the health clinic, Bernadette Nassa, was insistent. She explained that the tiny rods were there for a reason: They provided the womansbody with a hormone to keep her from having children. She needed to give her body rest before becoming pregnant again.Eventually, the husband relented.
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But, Nassa said, theres not always ahappyending. Shes seen womenwhose husbands insist on a divorce if their wife usescontraception.
Such encountersunderscore the difficultyof providingcontraceptive services and womenshealth care inOuagadougou and in other developing countries where reproductivehealth education is limited and husbands make many decisions for their wives.
Did gender bias derail a potential birth control option for men?
But since May, the clinic hashad a new partner: Pathfinder International, a nonprofit geared towardincreasing global access to reproductive health services. And soon many more clinics could receive their help. Pathfinder last month received a $10 million grant from theBill and Melinda Gates Foundation, based in part on the work theyve done in Burkina Faso, to study how tohelp women get access to contraception.
For instance,Nassas clinic is one of 84 in Burkina Faso that have received the tools to insert an intrauterine device, or IUD, from Pathfinder, according toDr. Bruno Ki, the organizations technical director in the country. Before that, theclinic didnt even have the basic specula and tongs used in gynecological exams. Since May, Nassaestimates, theclinic has performed 30 or 40 IUD insertions a month, and the devices remaineffective for up to 12 years.
Each morning, a hundred women crowd into Nassas small waiting room and spill out into the courtyard; she and her staff, just under a dozen, cant take care of all of them. Her cement clinic only has four rooms for patients, so one doubles as a birthing suite and a family planning consultation room.
Demand for the clinics services has soared since the government started subsidizing health care for new mothers and young children in April. Now, health care is free for womenfor six weeks after they give birth.
That makes for a crucial juncture for Nassa to intervene. Back-to-back births carry higher risks for both mother and baby, and non-hormonal methods of contraception, including IUDs, are safe to use while the woman is still breastfeeding.
If she comes in with her child, we can use that opportunity to chat with her about contraceptive methods before she gets pregnant again, Nassa said through a translator. She tells the women about all kinds of contraceptive methods, including IUDs.
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Pathfinder is also funding improvements at other health clinics around the city. It is building a cement incinerator for medical waste at a health clinic in Bangpoor, a poor neighborhood by the railroad tracks to Abidjan, where the current incinerator was nothing more than a brick fire pit in which a stack of papers smoldered next to a jumble of aluminum and a can of insecticide that had not yet exploded.
Meanwhile, the organization is working at a national level to change the countrys laws on abortion.
Abortion law is very restrictive in Burkina Faso, Ki said. In 2012, we [had] more than 105,000 unsafe abortions in Burkina Faso.
Currently, abortions are only legal if ordered by a judge, and only in four cases: rape, incest, if the mothers health is at risk, or if there is a high probability the child will be born with an incurable congenital disorder.
As a result, many women try to induce an abortion, with horrifying results. Ki has heard stories about women who stuck bleach pills into their vagina or drank soup laced with ground glass.
If the new statute is adopted, women would be able to receive an abortion if their mental health or social well-being is at risk. The legislature was supposed to vote on the changes in October, but never did, Ki said, and hes not sure when they will pick it up in the future.
If those at Pathfinder want their work to have a lasting impact, they know that it will have to involve changing the attitudes of husbands and mothers-in-law, who often exercise a lot of control over a womans choices.
A few years ago, Pathfinder completed a project where it educated mothers-in-law about the importance of contraception, convincing them to accompany their daughters-in-law to the health clinic. Ki said the project was successful: Pathfinder worked with local nongovernmental organizations to talk with hundreds of mothers-in-law, some of whom later accompanied their daughters-in-law to receive contraception.
And Nassa acknowledged that one of the reasons so many husbands abhor contraception is that their ideas are based on rumors; they rarely learn how implants, IUDs, or injections actually work.
And that can lead to confrontations like the one Nassa experienced with the angry husband last month.
Here in Africa, especially in Burkina Faso, a woman cannot take a decision by herself, she said through a translator. It is the men that decide.
Kate Sheridan contributed reporting.
Ike Swetlitz can be reached at email@example.com Follow Ike on Twitter @ikeswetlitz
DEAR MAYO CLINIC: How is thyroid cancer treated? Does it always require taking out the thyroid? When is iodine treatment used, and how does that work?
Treatment for thyroid cancer usually involves removing all or part of the thyroid gland. In cases where thyroid cancer is advanced or aggressive, radioactive iodine treatment may be recommended after surgery to destroy any cancer cells that couldn’t be removed during surgery. For very small papillary thyroid cancers (less than 1 centimeter in diameter and completely confined to the thyroid on ultrasound examination), it may be reasonable to avoid surgery and monitor them periodically without treatment. This is termed “surveillance” and requires annual imaging of the thyroid with high-quality ultrasound. These small thyroid cancers are low risk for progression, especially in persons over 60.
The thyroid is a butterfly-shaped gland located in the midline of your neck, about halfway between your Adam’s apple and your breastbone. Your thyroid gland produces two main hormones: thyroxine, or T4, and triiodothyronine, or T3.
Thyroid hormones impact many cells within your body. They maintain the rate at which your body uses fats and carbohydrates, help control your body temperature, affect the working of your nervous system, and influence your heart rate. Your thyroid gland also produces calcitonin, a hormone that helps regulate the amount of calcium in your blood.
Thyroid cancer is not common in the U.S. When it is found, though, most cases can be cured. Surgery to remove all or most of the thyroid a procedure called a thyroidectomy is often the first step in treatment.
Thyroidectomy typically involves making an incision in the center of the neck to access the thyroid gland directly. In addition to removing the thyroid, the surgeon may remove lymph nodes near the thyroid gland if the cancer is known or suspected to be spreading outside the thyroid. Then, those lymph nodes will be checked for cancer cells. An ultrasound exam of the neck before surgery can help doctors determine if lymph node removal is necessary.
When thyroid cancer is found in its earliest stage, and the cancer is very small, it may only be necessary to remove one side, or lobe, of the thyroid, and leave the rest in place. In that situation, the thyroid still can function and produce hormones.
When the entire thyroid is removed, lifelong thyroid hormone therapy is required to replace the thyroid’s natural hormones and regulate the body’s metabolism. In addition to supplying the missing hormone the thyroid normally makes, this medication also suppresses the pituitary gland’s production of thyroid-stimulating hormone, or TSH. That’s useful, because there’s a possibility that high TSH levels could foster the growth of any remaining cancer cells.
If thyroid cancer is found in its later stages, if it’s a more aggressive form of cancer, or if it is cancer that has come back after earlier treatment, then radioactive iodine therapy may be recommended after the thyroid has been removed.
Radioactive iodine comes in a capsule or liquid that’s swallowed. The therapy works because thyroid cells naturally absorb iodine. So when the medicine is taken up by any remaining thyroid cells or thyroid cancer, the radioactivity destroys those cells. Because the thyroid is the primary site where iodine is absorbed by the body, there’s a low risk of harming other cells with this treatment. Afterward, the radioactive iodine leaves the body through urine.
If thyroid cancer is not cured with a combination of surgery and radioactive iodine therapy, then chemotherapy, external radiation therapy or other treatment may be necessary. Fortunately, surgery cures most cases of thyroid cancer, and the long-term outlook after the procedure is usually excellent. John Morris III, M.D., Endocrinology, Mayo Clinic, Rochester.
Mayo Clinic Q & A is an educational resource and doesnt replace regular medical care. Email a question to MayoClinicQ&A@mayo.edu. For more information, visit http://www.mayoclinic.org.
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Most cases of thyroid cancer are curable – Post-Bulletin
Gender dysphoria is one of few identities still deemed a health issue that requires diagnosis same-sex desire was removed from the Diagnostic and Statistical Manuel (DSM) in 1973. In order to medically transition and get safe access to hormones and other support, transgender people need to come out to a doctor and are often required to attend therapy.
In 2013 England’s National Health Service’s (NHS) changed protocol for gender dysphoria patients, asking general practitioners to refer to a gender clinic which can offer much needed services like hormone treatment, hair removal treatments, and family support groups. Yet, many GPs still refer first to a counselor who may have little to no experience with gender identity.
Gina Denham, a transgender police officer in England, is teaming up with the NHS to change that, according to Echo. It’s her hope to provide trans patients in the area the support they need during transition, and get them access to one of the 7 designated NHS gender identity clinics in England.
One of the biggest barriers and potential cost to the NHS is our GPs sending our members to have counseling when they are meant to be referred to a gender clinic,” Denham told Echo. “The GP just seems to ignore your request and sends you to counseling to try and cure you.”
When she started to transition in 2014, Echo reports, Denham went to about 65 counseling sessions many of which were unnecessary.
Since then, Denham has become a champion for transgender rights in her community. Educating doctors is not her first project. In early 2016 Denham started a support group called Transpire for LGBTQ people in her neighborhood, which provides people the opportunity to both socialize with others who’ve had similar experiences and to engage in activist work. The Transpire group has helped educate medical professionals by working with the NHS on training materials.
When a woman becomes pregnant, many changes occur in her body. One of those changes is in the levels of various hormones produced by the body.
In the case of thyroid-stimulating hormone (TSH), pregnant women typically produce a lower level than normal (0.44.0 milli-international units per liter). Some international guidelines recommend levels be no higher than 2.5-3. milli-international units per liter during pregnancy. When their TSH levels rise above this, they may experience subclinical hypothyroidism, or mildly underactive thyroid, which can cause a number of health problems if left untreated.
Today, Mayo Clinic researchers report that one of those results could be pregnancy loss. Researchers further suggest a course of action that could positively impact as many as 15 of every 100 pregnancies. In a study published in The BMJ, they show that treating subclinical hypothyroidism (not quite the level that would be treated in a nonpregnant woman) can reduce pregnancy loss, especially for those with TSH levels on the upper end of normal or higher.
A recent analysis of 18 studies showed that pregnant women with untreated subclinical hypothyroidism are at higher risk for pregnancy loss, placental abruption, premature rupture of membranes, and neonatal death, said Dr. Spyridoula Maraka, an endocrinologist and lead author of the study. It seemed likely that treating subclinical hypothyroidism would reduce the chance of these deadly occurrences. But we know that treatment brings other risks, so we wanted to find the point at which benefits outweighed risks.
Using the OptumLabs Data Warehouse, Maraka and her team examined the health information of 5,405 pregnant women diagnosed with subclinical hypothyroidism. Of these, 843 women, with an average pretreatment TSH concentration of 4.8 milli-international units per liter, were treated with thyroid hormone. The remaining 4,562, with an average pretreatment TSH concentration of 3.3 milli-international units per liter, were not treated.
Photo: Paul Chinn, The Chronicle
Heather Jacoby plays the piano with her 7-year-old daughter, Billie. Jacoby, who received lifesaving treatment at a Planned Parenthood facility, is upset by efforts to end federal funding for the organization.
Heather Jacoby plays the piano with her 7-year-old daughter, Billie. Jacoby, who received lifesaving treatment at a Planned Parenthood facility, is upset by efforts to end federal funding for the organization.
Heather Jacoby of Vacaville, shown with daughter Billie and dog Jazzie, says she was referred to Planned Parenthood by an emergency room doctor.
Heather Jacoby of Vacaville, shown with daughter Billie and dog Jazzie, says she was referred to Planned Parenthood by an emergency room doctor.
Nationwide Planned Parenthood protests energize patients, opponents
Damien Cox didnt have health insurance for most of his life. So when the transgender man began transitioning 11 years ago, he went to a Planned Parenthood clinic for hormone treatments.
Planned Parenthood isnt just a womans thing, said Cox, a 40-year-old Sunnyvale resident. Its a queer health issue and a trans health issue. It affects everybody.
Cox is among those voicing support for the nonprofit reproductive health organization at what could be a critical moment in its history. President Trump and his administration have threatened to eliminate federal funding for Planned Parenthood, because the services provided by the clinics include abortions.
On Saturday, the debate will crest with nationwide rallies including at clinics in San Francisco, Redwood City and Napa calling for the defunding of Planned Parenthood.
The whole issue would go away if they just didnt offer abortion services, said Monica Migliorino Miller, a Michigan resident who is part of a coalition of antiabortion groups that organized the demonstrations.
Supporters are planning counter-protests, arguing that a loss of funding would hurt an array of patients, and in particular low-income and minority communities. Planned Parenthoods services include prenatal care, testing and treatment for sexually transmitted infections, cancer and diabetes screenings and vaccinations.
In the fiscal year that ended in June 2015, Planned Parenthood received $553.7 million in Medicaid reimbursements and federal grant money, according to the groups latest annual report 43 percent of its total budget.
Under federal law, none of that money went toward abortion services, which make up 3 percent of all services provided, barring situations where a womans life was in danger or cases of incest and rape, said Gilda Gonzales, the interim chief executive of the organizations Northern California affiliate.
If the group was defunded, Gonzales said, 60 percent of Planned Parenthoods clientele would lose care provided under Medicaid and the Title X family planning program. The vast majority of patients in Northern California range from ages 20 to 35, are people of color and live below the poverty line, she said.
But opponents of abortion believe stripping all federal funding will help their cause. Vice President Mike Pence, speaking at the annual March for Life in Washington, D.C., on Jan. 27, said ending taxpayer abortions was a priority for the new administration.
At a GOP debate in Houston in February 2016, Trump pointed out that millions and millions of women cervical cancer, breast cancer are helped by Planned Parenthood. But he said, I would defund it because of the abortion factor, which they say is 3 percent. I dont know what percentage it is. They say its 3 percent. But I would defund it, because Im pro-life.
Republicans in both the House and Senate plan to introduce measures to end federal funding for Planned Parenthood and ban most abortions after 20 weeks of pregnancy, which Trump has pledged to sign.
While supporters of the group say the right to a safe abortion is critical, they are also working to bring more awareness to Planned Parenthoods other services. They include Nique Eagen, a 41-year-old Campbell resident, who will be among an expected 3,000 counter-protesters in San Jose.
For years, Eagen said she suffered through intense pain and nausea during her menstrual cycles, but didnt understand why.
I would get really, really sick, Eagen said. I was getting dehydrated. Id black out because I was losing too much blood.
After she lost her job in 2010, she sought care from Planned Parenthood and learned that the cause of her pain was ovarian cysts a problem that was solved by taking birth control, which keeps the cysts from growing, she said.
Heather Jacoby, a 31-year-old Vacaville resident, said she turned to Planned Parenthood when she ran out of other options.
Last summer, she was thrilled when she found out she was pregnant. But within weeks, she wound up in the emergency room due to severe pain, vomiting and blacking out. She had lost the baby and gone into septic shock.
I was carrying a dead fetus inside me for over six weeks. I felt hopeless, Jacoby said.
Jacoby didnt want an abortion but needed one to save her life. She had insurance, but said her primary care provider didnt immediately schedule the procedure. When she ended up in the emergency room, a doctor referred her to Planned Parenthood in Walnut Creek, she said.
I still remember the day because two of my good friends gave birth that day, Jacoby said. Before it started, I just started crying because this is the culmination of six weeks and I was so exhausted and I just remember the nurse (at Planned Parenthood) grabbed my hand and looked in my eyes and said, I got you.
Sarah Ravani is a San Francisco Chronicle staff writer. Email: firstname.lastname@example.org Twitter: @SarRavani
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Nationwide Planned Parenthood protests energize patients, opponents – SFGate
Amphetamine abuse is increasing internationally. While common sides effects of the drug include increased heart rate, headache, stomach pain, and mood changes, little is known about the drug’s effect on the heart. Now, new research published in Heart Asia reports that using amphetamines recreationally may accelerate aging of the heart.
Recreational amphetamine, commonly known as “ice,” “speed,” and ecstasy, is a central nervous system stimulant. Amphetamine sends the part of the nervous system that functions to accelerate heart rate, constrict blood vessels, raise blood pressure, and produce the “fight or flight” hormone adrenaline, into overdrive.
Given the effect of amphetamine on heart rate, blood vessels, and blood pressure, the abuse of stimulants is likely to have a stressful effect on the cardiovascular system over time. However, there have previously been few studies that explore these processes.
It is known that prolonged stimulant use causes premature aging of the skin. Following on from this knowledge, researchers from the University of Western Australia (UWA) aimed to find out whether amphetamine use prematurely ages the heart.
Albert Stuart Reece, associate professor of medicine at UWA, and collaborators measured levels of blood flow through the brachial artery in the upper arm, as well as the radial artery in the forearm, of 713 study participants.
Arteries harden as the body ages, and so the researchers aimed to assess the degree of artery stiffening in order to determine how the heart was aging in this population. The participants were in their 30s and 40s and attending a clinic for substance misuse.
The team used a standard blood pressure cuff on the upper arm of participants and a noninvasive monitoring system, called SphygmoCor, on the forearm to gather data.
SphygmoCor uses software that can calculate the biological vascular age of a person by matching the age, sex, and height of an individual with the extent of arterial stiffening.
The participants were divided into four groups depending on their drug use. There were 483 people who did not smoke, 107 people who did, 68 individuals who used the heroin substitute methadone, and 55 users of amphetamine.
Of the 66 times that the amphetamine group was monitored with the SphygmoCor, 94 percent of individuals had used the drug within the previous week, and almost half of the people in the group had used it the day before.
Findings indicated that compared with the people who smoked and used methadone, the cardiovascular system of the amphetamine users appeared to be aging at a much quicker rate.
These results remained significant when other known cardiovascular risk factors – such as weight, cholesterol levels, and the inflammation indicator C-reactive protein – were taken into consideration.
As exposure to amphetamine is often repetitive and prolonged, the heart is exposed to the effects of the stimulant on a behavioral, chronic, and long-term basis. “It is, therefore, conceivable that stimulant abusers do physiological and cardiovascular harm,” says the team. They note that it is not clear to what extent the damage might be reversible.
The authors say that the results confirm their concerns that amphetamine abuse increases heart age. However, as the study is observational, no firm conclusion can be drawn regarding cause and effect.
The aging process suggests a power function over time, as many physiological processes begin to fail over the course of a lifespan progressively. However, the new findings suggest that stimulant abuse may accelerate the degeneration of the physiological systems. The authors write:
“If, as has been demonstrated, the damage from stimulant abuse is actually a power function of time, then this, in turn, implies that the gathering global stimulant epidemic carries a further message of urgency which has largely not been appreciated.”
The team point to other research for a possible explanation for their findings. The research showed that amphetamine use interferes with stem cell functioning and normal cell division. Hence, amphetamines may both impede tissue repair and increase tissue injury, the authors conclude.
Learn how synthetic marijuana may have a variety of adverse health effects.
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Amphetamine use may ‘speed up’ heart aging – Medical News Today
By Molly Atchison | Opinion Editor
Editors Note: This is the thirdinstallment in a four-part series about gender transition and the issues surrounding it. For the personal safety of some of the individuals mentioned below, last names have been omitted.
Physical health is a multi-faceted issue that transgender people focus on once theyve determined that they want to begin their transition. Many health professionals point to the World Professional Association for Transgender Healths Standards of Care manual to give transitioning individuals a jumping off-point for research into sexual and physical health.
The first step in the transition process is to go through hormone therapy process, and the second step of the process is to commit to the sex-reassignment surgery.
For McLennan County junior Jessica, a transgender student attending Baylor University, beginning these transitions was not an easy decision to make.
I was praying and thinking about this decision for about a year before I began the process at all, Jessica said.
Jessica began her hormone therapy process almost a year ago. The Standards of Care manual states that hormone therapy is the administration of exogenous endocrine agents to induce feminizing or masculinizing changes.
In Fall of 2015, I began taking steps towards hormone therapy. I worried about the haters and the higher rate of suicide, but I kept pushing on until I got what I set out to achieve, Jessica said.
Testosterone and estrogen are two main hormones in the body. Every human has varying levels of testosterone and estrogen in their bodies, and the hormones will rise and fall naturally to maintain a healthy physical equilibrium. Both of these are the hormones that are supplemented in the transition process.
According to the Center of Excellence in Transgender Health, in a female-to-male transition, an individual will take testosterone supplements to help introduce general changes such as facial hair growth, deepening of the voice and redistribution of muscle and weight gain. This transformation happens over the course of 12 months, which is the general requirement to be eligible to receive the sex-reassignment surgery.
In contrast, the male-to-female transition can be administered with several different categories of estrogen supplements. According to the Center of Excellence in Transgender Health, these estrogen supplements aid in breast development, vocal shifting and the redistribution of fat and muscle on the body.
The Standards of Care manual says that the physical side effects of these therapies most commonly include decreased auto-immunity, lack of genital functioning and many other symptoms of raised or lowered increased levels of testosterone and estrogen. Other side effects include a higher risk of breast cancer in both types of patients, as well as other forms of cancer and genetic diseases, including heart disease and diabetes.
Now that Jessica is nearing the end of her initial hormone treatment, she awaits approval to continue to the sex-reassignment surgery.
The final step in the transition process is the sex-reassignment surgery. According to Transequality.org, sex-reassignment surgeries are Surgical procedures that change ones body to better reflect a persons gender identity.
For male-to-female patients, the Standards of Care manual cites two basic surgeries, the first being breast enhancement, and the second being a series of up to five smaller procedures to replace the existing male genitalia with female genitalia. Different doctors choose to use different techniques of genital conversion in the male-to-female transition.
In the same way, female-to-male patients go through a series of different surgeries, as is stated in the Standards of Care manual. They will undergo a surgery to remove the breasts, called a mastectomy, and then several surgeries that remove the female genitalia, and then phalloplasty that adheres a phallic implant in its place. One of the biggest differences between these surgeries is that with male-to-female transitions it is more common to use existing tissue to create the new genitalia, whereas in the female-to-male, fresh tissue is more commonly implanted.
There are many risks to undergoing such significant surgeries, which can be found online in the Standards of Care manual. I do fear the pain of recovery and the possibility of complications that any surgery could have, even as severe as death, Jessica said.
Health after surgery:
Along with risks during surgery, there are risks in the years following the surgery. However, the Center of Excellence for Transgender Health is one of the leading researchers in transgender health. Their guidelines have detailed lists of general and sexual health problems transgender people may face post-surgery including but not limited to Sexually Transmitted Diseases, blood pressure problems and reproductive health issues.
The Baylor Health Clinic also offers primary care services. Medical Director of Baylor Health Services Sharon Stern, M.D., said As primary care physicians and nurse practitioners, we care for the patients who come into the clinic. That means that we can do any testing and treatment of many infections, including sexually transmitted ones.
Stern acknowledges that the clinic, being a primary care clinic, does not directly identify or prescribe transgender treatments. However, the electronic medical records system the center allows healthcare professionals to make sure that the general medications they may be prescribing to a transgender individual will not counteract the hormone supplements they are taking.
If we had a patient present to us who was thinking of transitioning, we would most likely refer them to a counselor and an endocrine doctor who specializes in the type of specialized hormonal treatment necessary. We want to help all patients and we strive to never be judgmental. We want to help all Baylor students be healthy, she said.
TheNational Institute of Diabetes and Digestive and Kidney Diseases, a part of the National Institutes of Health, has given out $41 milion in grants to four studies that will hopefully make the artificial pancreas a long-sought, fully automated, closed-loop system for insulin regulation a reality. Two of the studies are underway and two more are slotted to begin recruiting in the next two years.
Managing type 1 diabetes currently requires a constant juggling act between checking blood glucose levels frequently and delivering just the right amount of insulin while taking into account meals, physical activity, and other aspects of daily life, where a missed or wrong delivery could lead to potential complications, Dr. Andrew Bremer, the NIDDK program official overseeing the studies, said in a statement. Unifying the management of type 1 diabetes into a single, integrated system could lift so much of that burden.
A long-sought dream of diabetes technologists, an artificial pancreas would combine the functionality of an automated insulin pump and a continuous glucose monitor, automatically calculating dosages and delivering insulin based on readings from the CGM — in essence replicating the behavior of a normally-functioning human pancreas, which regulates insulin in people without diabetes.
The four studies all vary from previous artificial pancreas studies in a few key ways. For one thing, they will each have 100 or more participants. For another, while previous studies looked at geographically co-located cohorts at summer camps for youth with diabetes or hotels near the study site, these studies will be conducted at multiple sites, remotely, allowing researchers to test the systems in natural, real-life contexts.
The studies will hopefully provide the data the FDA needs to clear a fully closed-loop system. Last year the FDA cleared Medtronic’s artificial pancreas, but that was a hybrid system that still required patients to manually adjust insulin intake at mealtimes.
We wrote about one of the four studies when it began enrollment last year.The International Diabetes Closed Loop trial at the University of Virginia aims to enroll 240 adults with type 1 diabetes. The participants will come from 10 different clinical sites throughout the world including Mount Sinai Hospital in New York, Stanford University Hospital and the Mayo Clinic in the United States, as well as medical centers in France, Italy and the Netherlands. A Tandem insulin pump and Dexcom G5 sensor will be included as part of a blood glucose control system that combines the devices with a smartphone running TypeZeros closed loop algorithm app inControl.
The other study that has already begun recruiting isled by Dr. Roman Hovorka of the University of Cambridge in England. The 130-person study of teenagers, which looks at a system called FlorenceM using an Android smartphone and Medtronic devices, will be conducted at sites in California, Colorado, Connecticut, Minnesota, and two sites in the United Kingdom.
A third study is scheduled to begin recruiting this year. It’s led by researchers from theInternational Diabetes Center in Minneapolis and the Moshe Phillip of Schneider Children’s Medical Center in Petah Tikva, Israel and will include 100 youthsat sites in California, Connecticut, Florida, Massachusetts and Minnesota and abroad in Germany, Israel and Slovenia. It will compare the FDA-cleared hybrid system with a next-generation version of that system from Medtronic.
Finally, the fourth study will kick off in 2018, led by researchers in Boston from Massachusetts General Hospital and Boston University.The six-month study is a little different from the others — it looks at a bionic pancreas system, with a dual-chamber pump to deliver both insulin and its counteracting hormone, glucagon, using tested algorithms for automated dual-hormone delivery. The study will include two sites in California and one each in Massachusetts, Michigan, Missouri, North Carolina, Ohio and Washington.
For many people with type 1 diabetes, the realization of a successful, fully automated artificial pancreas is a dearly held dream. It signifies a life freer from nightly wake-up calls to check blood glucose or deliver insulin, a life freer from dangerous swings of blood glucose, said NIDDK Director Dr. Griffin P. Rodgers. Nearly 100 years since the discovery of insulin, a successful artificial pancreas would mark another huge step toward better health for people with type 1 diabetes.
See the original post here:
Four NIH-backed projects aim to advance the artificial pancreas – MobiHealthNews
A ribbon cutting ceremony will take place Wednesday, Feb. 8 at the Somerville campus of Robert Wood Johnson University Hospital. The Somerset County hospital is now the first in the entire state of New Jersey to open a family health center tailored to the LGBTQ community.
PROUD Family Health will offer services most important to LGBTQ New Jerseyans. In a recent press release, RWJUH president Michael Antoniades said, We recognized that the health care needs of the LGBTQIA community were not being met and in many cases, LGBTQIA individuals were traveling outside of New Jersey for their medical care. PROUD Family Health will offer them the care they need close to home.
A resource like this can be extremely beneficial to many New Jerseyans. It also sets a precedent for other New Jersey hospitals moving forward. The fact of the matter is the LGBTQ community has different priorities when it comes to healthcare.
I reached out to Christian Fuscarino, the Executive Director of New Jerseys largest civil rights organization, Garden State Equality, about this news. He had this to say:
Today we take an important step forward as a community and a state, with the opening of the first full service LGBT health clinic.
The PROUD Family Health Clinic at Robert Wood Johnson will provide medical care for children and adults, hormone therapy and monitoring, HIV care, referrals for specialty services, health education and counseling, and support groups for LGBT individuals and their family members.
Garden State Equality is proud to partner with RWJ on this project that makes New Jersey a national leader in the health care space.
Currently, operating hours will be on Mondays from 6 pm to 9 pm, although I would expect that to expand as demand increases. Medicare, Medicaid and most major insurance plans are accepted.
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The University of Nebraska-Lincoln campus got a little more trans-friendly on Feb. 1. The University Health Center opened a new clinic geared toward transgender and non-binary students, staff and faculty. After years of requests for the clinic, Dr. Jean Amoura will begin treatment for transgender patients at the university as an extension of her Nebraska Medicine practice in Omaha.
With easy access to a safe, affordable and knowledgeable clinic, trans students, faculty, and staff are now able to focus more on education, rather than whether or not they will have the care they need. It eliminates a concerning barrier, and it is validating for these individuals to have their needs recognized.
Over the past few years, there has been an increase in the amount of resources and services available to queer and trans individuals on campus. This includes other health services like LGBT-friendly counseling, with the option to see someone who has specialization in LGBT issues. There are also LGBT-centric social and community resources and organizations such as Spectrum and The Change, the LGBTQA+ Resource Center, a growing number of gender-inclusive housing options and numerous gender-inclusive bathrooms scattered around campus. Finally, there are opportunities for allies and queer people to be educated about queer issues, and there is also an LGBT-geared mentor program. As the campus continues to become more diverse, these various services become even more vital.
The Transgender Care Clinic is yet another massive step toward a more welcoming environment for queer and trans individuals at UNL. This should be an example to not only the rest of the universities in the Nebraska system, but also to universities across the nation. Currently, only 75 of all American colleges and universities cover both hormone treatment and gender-affirming surgeries under student health insurance.
Across the country, it is already incredibly difficult to find healthcare professionals who know how to treat transgender patients. Unfortunately, some insurance providers do not cover trans-related health services, and with the threat of the Affordable Care Act being repealed, queer and transgender patients face the risk of having even fewer options.
In Nebraska specifically, some health insurance providers can legally exclude transgender-specific services. In the case of discrimination from private health insurance providers, there is no protection for trans and queer folks, and Nebraska Medicaid does not cover transgender-related healthcare.
According to a Movement Advancement Project report, Nebraska ranks number three for the worst state for gender identity related policies, ranking up the most negative points in the category of healthcare and safety. As a nation, 52 percent of the queer and transgender population lives without LGBT-inclusive health insurance.
With such disparities in these services across the nation, and particularly in Nebraskas healthcare, the transgender health clinic on campus is a victory for some. While helping transgender Nebraskans, it also provides reliable care to out-of-state students who may or may not have inclusive healthcare in their home state. This simplifies the difficult process of finding a healthcare provider and professional willing to cover said treatments, while aiming to protect the wellbeing of those who use or need this type of care.
The next step for Nebraska as a state is to follow the footsteps of the university. With trans people experiencing dishearteningly high rates of depression, attempts of suicide and substance abuse, the need for healthcare designed for transgender people is always growing. Queer and trans people deserve to receive the healthcare they need. Ideally, Nebraska will take steps to provide that in the future.
Ellie Bruckner is a sophomore global studies major. Reach her at email@example.com or via @DNOpinion.
See the article here:
BRUCKNER: UNL a national model for trans, LGBT care – Daily Nebraskan
A study group from the Mayo Clinic found that thyroid hormone treatment of subclinical hypothyroidism during pregnancy was associated with a lower risk of pregnancy loss, but a higher risk for adverse pregnancy outcomes such as premature birth and gestational diabetes.
Subclinical hypothyroidism (hypothyroidism proven by laboratory results without clinical symptoms) affects around 15% of pregnant women. The recent regulatory changes in laboratory TSH (thyroid stimulating hormone an indicator of low thyroid hormone levels) threshold may have resulted in an overdiagnosis and overtreatment of hypothyroidism. A lower thyroid hormone level during pregnancy has been associated with adverse pregnancy outcomes such as pregnancy loss, placental abruption, premature rupture of membranes, and neonatal death.
An article was recently published in the British Medical Journal that analyzed data from the OptumLabs Data Warehouse database to assess the prevalence, effectiveness, and safety of thyroid hormone treatment of subclinical hypothyroidism among pregnant women. Researchers included 5405 pregnant women in the study with TSH 2.5-10mIU/L between 2010 and 2014. 15.6% received thyroid hormone treatment and the percentage of treated women increased each year. Comparing the treated and untreated groups, treated patients had a 38% lower risk of pregnancy loss, but higher odds of preterm delivery, gestational diabetes, and pre-eclampsia. However, the risk of pregnancy loss was only lower in treated women with higher TSH levels (meaning lower thyroid hormone levels) but not in women with lower TSH. Furthermore, the risk of gestational hypertension was higher among treated than untreated women with lower TSH levels.
In conclusion, it seems that thyroid hormone therapy of subclinical hypothyroidism lowers the risk of pregnancy loss, especially in patients with higher TSH levels, but is associated with a higher risk of adverse pregnancy outcomes. Further studies are needed to assess the safety of thyroid hormone treatment in pregnancy.
Written By: Dr. Fanni R. Eros
A new video campaign is calling on the Alberta government to provide more funding to help transgender youth.
The only specialized, multi-disciplinary clinic in the province catering to transgender youth is at the Alberta Children’s Hospital in Calgary and is only open one half-day each month as part of a pilot project.
The waiting list for the clinicis up to three years.
“We’re hearing a lot of kids stuck in that long wait, and what we’re hearing a lot of is desperation,” said Amelia Newbert, who runs the Skipping Stone Foundation, the organization behind the video campaign.
The Metta Clinic at the children’s hospital provides everything from mental health and psychiatric support, to hormone therapy and preparation for some surgeries for youth aged seven to 20.
Newbert, who is trans,says timing is key with kids.
“The reality of being forced to be exposed to a puberty that doesn’t conform to your gender identity is profoundly damaging,” she said.
That damagecan lead to an increase in problems such as self-harm, addiction and suicide, according to Newbert.
In thefirst video of the Skipping Stone campaign,Ace Peace, a 16-year-oldtransgenderboy, describes the desperation he felt watching his body change while he waited nine months to get into the clinic.
“When I came out as transgender everyone supported me. I was supported by family, friends and school. But it was still hell for me,” he says.
“I was watching my body change in ways I didn’t want to see it change. I felt like it was betraying me.”
Speaking with the Calgary Eyeopeneron Tuesday morning,Peace said he was struggling at school andthe clinic provided much needed emotional support.
“They knew what to do, they knew what was going on, they knew the emotional impact that it had on me so they tried to get me on hormones as fast as they could,” he said.
Pam Krause, whoruns the Calgary Sexual Health Centre, agrees it’s important to offer support early.
“If you have to wait three years for something, for something that you know is your truth, Ithink that causes all kinds of difficulties for people. And the system is paying later on when people are having mental health problems,” she said.
Alberta Health Services told CBC News that it continues to examine the pilot project, launched in 2014.
“AHS is currently gathering evidence and exploring best practices to determine the best approach to providing services to youth struggling with gender dysphoria,” said an email fromJulie Kerr, the health authority’ssenior operating officer foraddictions andmental health in theCalgary zone.
“Any decisions on whether to expand the clinic will be evidence-based.”
Alberta’s health minister, Sarah Hoffman, said she understands the long delays are frustrating.
“While there are a number of health services that can support transgender youth in different parts of the province, having a designated service like the Metta Clinic has proven invaluable for many patients and families,” she said by email.
Kerr said youth struggling with gender identity can find other programs and services in Alberta, including community mental health programs, crisis mental health, family physicians, edrocrinologyand psychiatry services.
Risk of Pregnancy Loss in Subclinical Hypothyroidism
Rozalina G McCoy, MD, from the Mayo Clinic in Rochester, Minnesota, and colleagues conducted the first national study to evaluate the effectiveness and safety of thyroid hormones for pregnant women with subclinical hypothyroidism. The study included …
NEW ALBANY Carla Copas, APN, is announced the grand opening of Finding Her Health, a new womens health care clinic located at 2708 Paoli Pike, Suite I, New Albany. A ribbon cutting ceremony will be held Feb. 8, at 10 a.m.
Copas specializes in Bio-Identical Hormone Replacement and has been prescribing this type of treatment to her patients with great success for 15 years. Formerly with OBGYN Associates of Southern Indiana, she is opening Finding Her Health to more fully utilize her skill and passion for a personalized approach to healthcare.
As an advanced practice registered nurse, I treat the whole person, not just the diagnosis or disease, Copas said in a news release. Unlike other healthcare offices where there are sometimes dozens of people in the waiting room and the providers see 30-40 patients a day that is one every 5-10 minutes, I take the time with each patient for education and understanding. Most of my patients have a time slot from 30 minutes to one hour. I provide same-day appointments and am available to my patients via secured email and answer within 24 hours.
Services available at Finding Her Health will include gynecology, STI testing and treatment, birth control options, hormone balance, well woman exams, treatment for UTIs, vaginal problems, painful intercourse, decreased libido, irregular menses, fertility, peri-menopause and menopause balance, prevention and other issues specific to womens health.
Im excited about this new venture. Opening this clinic will provide a unique opportunity for me to help women in all walks of life, Copas said. At Finding Her Health, no matter what a womans age or medical situation, I want to help guide my patients to feeling the best they have ever felt.
The public is invited to attend the ribbon cutting ceremony to meet Copas and tour the new office. For more information, visit http://www.findingherhealth.com or Facebook/findingherhealth.
After a massive mess up with the NHS recently (a long story) I finally managed to get my AMH (Anti-Mullerian hormones) tested last week at a private clinic.
Facts and Figures
Im sure lots of you are already too familiar with the meaning of AMH, but just incase you are unfamiliar here is a bit more information from Lane Fertility Magazine:
Anti Mullerian Hormones (AMH)
Many physicians and researchers believe that the best blood test to assess the supply of follicles in a womans ovaries is Anti-Mullerian Hormone (AMH), also known as Mullerian Inhibiting Substance (MIS). In females, this hormone is secreted by a particular group of cells in the follicles called granulosa cells. Thus, the more follicles there are in the ovaries, the greater the amount of AMH in the blood. Conversely, the fewer follicles there are in the ovaries, the lower the amount of AMH in the blood. Therefore, AMH is a reflection of the number of follicles in both ovaries. With time, as women become older, the level of AMH will naturally decrease.
This graph was interesting about how AMH levels decline with age, read more about it atFertility Associates.
The ranges used in the U.K. and U.S. should be as follows:
AMH Blood Level
AMH Blood Level
Over 3.0 ng/ml
High (often PCOS)
Over 1.0 ng/ml
0.7 0.9 ng/ml
Low Normal Range
0.3 0.6 ng/ml
Note:Reference range formerly in g/L(conversion g/L pmol/L = 7.14)
Less than 0.3 ng/ml
I also found a great conversion chart, which was very useful as different information/labs seems to use different units of measurement.
Once again there is quite a lot of differing opinions about AMH. On my mission to source information I have found out that:
Can you imagine my surprise when I discovered that (once again) there are differing opinions and inconsistencies in the facts? Detect a hint of sarcasm? Sorry, I just couldnt resist! Once again my search for clear cut facts was in vain another grey area in this mixed up IF world.
My result came back as 8 pmol/L, in the low fertility bracket. My first reaction was to be upset (of course), but the nurse kindly explained that it isnt too bad; it is age related and lots can be done with an AMH of that level especially if I have been pregnant before. Also that it is more about quality, not quantity.
I also had a go at converting my result into ng/ml (as per the U.S. figures). I know, I know, before you say it, this is probably the wrong thing to do. They probably use different methods of testing, blah blah blah. But I couldnt resist, I was grasping at straws. And the result? 1.12 ng/ml which puts me in the normal range. Do I believe this? Im not sure, but I do like the sound of normal much more than low fertility.
So, yet again an emotional roller-coaster (albeit a small one this time) began:
What can I do about it? Nothing! Absolutely nothing! It frustrates me that time is my enemy and Im feeling the sense of urgency more than ever. But its not like Hubby and I havent been trying for the last two years what more can we do?
Your AMH Levels
Id love to hear what your AMH levels were and what you have been told about it. And Im sure there are plenty of others out there who are just as confused as I am about all this. Please comment, and lets get to the bottom of this!
Originally posted here:
Worrying about Anti Mullerian Hormones? | Baby Hopeful
PRL Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes
1RW5, 2Q98, 3D48, 3EW3, 3MZG, 3N06, 3N0P, 3NCB, 3NCC, 3NCE, 3NCF, 3NPZ
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that in humans is best known for its role in enabling mammals, usually females, to produce milk. It is influential in over 300 separate processes in various vertebrates. Prolactin is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation and nursing. Prolactin is secreted in pulses in between these events. Prolactin plays an essential role in metabolism, regulation of the immune system and pancreatic development.
Discovered in non-human animals around 1930 by Oscar Riddle and confirmed in humans in 1970 by Henry Friesen prolactin is a peptide hormone, encoded by the PRL gene.
It is associated with human milk production. In fish it is thought to be related to control of water and salt balance. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. It has important cell cycle-related functions as a growth-, differentiating- and anti-apoptotic factor. As a growth factor, binding to cytokine-like receptors, it influences hematopoiesis, angiogenesis and is involved in the regulation of blood clotting through several pathways. The hormone acts in endocrine, autocrine and paracrine manner through the prolactin receptor and a large number of cytokine receptors.
Pituitary prolactin secretion is regulated by endocrine neurons in the hypothalamus. The most important ones are the neurosecretory tuberoinfundibulum (TIDA) neurons of the arcuate nucleus that secrete dopamine (aka Prolactin Inhibitory Hormone) to act on the D2 receptors of lactotrophs, causing inhibition of prolactin secretion. Thyrotropin-releasing factor (thyrotropin-releasing hormone) has a stimulatory effect on prolactin release, however prolactin is the only adenohypophyseal hormone whose principal control is inhibitory.
Several variants and forms are known per species. Many fish have variants prolactin A and prolactin B. Most vertebrates including humans also have the closely related somatolactin. In humans, three smaller (4, 16 and 22kDa) and several larger (so called big and big-big) variants exist.[not verified in body]
Prolactin has a wide variety of effects. It stimulates the mammary glands to produce milk (lactation): increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands and prepare for milk production, which normally starts when the levels of progesterone fall by the end of pregnancy and a suckling stimulus is present. Sometimes, newborns (males as well as females) secrete a milky substance from their nipples known as witch’s milk. This is in part caused by maternal prolactin and other hormones. Prolactin plays an important role in maternal behavior.
Prolactin provides the body with sexual gratification after sexual acts: The hormone counteracts the effect of dopamine, which is linked to sexual arousal. This is thought to cause the sexual refractory period. The amount of prolactin can be an indicator for the amount of sexual satisfaction and relaxation. Unusually high amounts are suspected to be responsible for impotence and loss of libido (see hyperprolactinemia symptoms).
Elevated levels of prolactin decrease the levels of sex hormones estrogen in women and testosterone in men. The effects of mildly elevated levels of prolactin are much more variable, in women, substantially increasing or decreasing estrogen levels.
Prolactin is sometimes classified as a gonadotropin although in humans it has only a weak luteotropic effect while the effect of suppressing classical gonadotropic hormones is more important. Prolactin within the normal reference ranges can act as a weak gonadotropin, but at the same time suppresses GnRH secretion. The exact mechanism by which it inhibits GnRH is poorly understood. Although expression of prolactin receptors (PRL-R) have been demonstrated in rat hypothalamus, the same has not been observed in GnRH neurons. Physiologic levels of prolactin in males enhance luteinizing hormone-receptors in Leydig cells, resulting in testosterone secretion, which leads to spermatogenesis.
Prolactin also stimulates proliferation of oligodendrocyte precursor cells. These cells differentiate into oligodendrocytes, the cells responsible for the formation of myelin coatings on axons in the central nervous system.
Other actions include contributing to pulmonary surfactant synthesis of the fetal lungs at the end of the pregnancy and immune tolerance of the fetus by the maternal organism during pregnancy. Prolactin delays hair regrowth in mice. Prolactin promotes neurogenesis in maternal and fetal brains.
In humans, prolactin is produced at least in the anterior pituitary, decidua, myometrium, breast, lymphocytes, leukocytes and prostate.
Pituitary PRL is controlled by the Pit-1 transcription factor that binds to the prolactin gene at several sites. Ultimately dopamine, extrapituitary PRL is controlled by a superdistal promoter and apparently unaffected by dopamine. The thyrotropin-releasing hormone and the vasoactive intestinal peptide stimulate the secretion of prolactin in experimental settings, however their physiological influence is unclear. The main stimulus for prolactin secretion is suckling, the effect of which is neuronally mediated. A key regulator of prolactin production is estrogens that enhance growth of prolactin-producing cells and stimulate prolactin production directly, as well as suppressing dopamine.
In decidual cells and in lymphocytes the distal promoter and thus prolactin expression is stimulated by cAMP. Responsivness to cAMP is mediated by an imperfect cAMPresponsive element and two CAAT/enhancer binding proteins (C/EBP).Progesterone upregulates prolactin synthesis in the endometrium and decreases it in myometrium and breast glandular tissue. Breast and other tissues may express the Pit-1 promoter in addition to the distal promoter.
Extrapituitary production of prolactin is thought to be special to humans and primates and may serve mostly tissue specific paracrine and autocrine purposes. It has been hypothesized that in vertebrates such as mice a similar tissue specific effect is achieved by a large family of prolactin-like proteins controlled by at least 26 paralogous PRL genes not present in primates.
Vasoactive intestinal peptide and peptide histidine isoleucine help to regulate prolactin secretion in humans, but the functions of these hormones in birds can be quite different.
Prolactin follows diurnal and ovulatory cycles. Prolactin levels peak during REM sleep and in the early morning. Many mammals experience a seasonal cycle.
During pregnancy, high circulating concentrations of estrogen and progesterone increase prolactin levels by 10- to 20-fold. Estrogen and progesterone inhibit the stimulatory effects of prolactin on milk production. The abrupt drop of estrogen and progesterone levels following delivery allow prolactinwhich temporarily remains highto induce lactation.[verification needed]
Sucking on the nipple offsets the fall in prolactin as the internal stimulus for them is removed. The sucking activates mechanoreceptors in and around the nipple. These signals are carried by nerve fibers through the spinal cord to the hypothalamus, where changes in the electrical activity of neurons that regulate the pituitary gland increase prolactin secretion. The suckling stimulus also triggers the release of oxytocin from the posterior pituitary gland, which triggers milk let-down: Prolactin controls milk production (lactogenesis) but not the milk-ejection reflex; the rise in prolactin fills the breast with milk in preparation for the next feed.
In usual circumstances, in the absence of galactorrhea, lactation ceases within one or two weeks following the end of breastfeeding.
Compared to un-mated males, fathers and expectant fathers have increased prolactin concentrations.
Levels can rise after exercise, high-protein meals,sexual intercourse, breast examination, minor surgical procedures, following epileptic seizures or due to physical or emotional stress. In a study on female volunteers under hypnosis, prolactin surges resulted from the evocation, with rage, of humiliating experiences, but not from the fantasy of nursing.
Prolactin levels have also been found to rise with use of the drug MDMA (Ecstasy), leading to speculation that prolactin may have a role in the post-orgasmic state as well as decreased sexual desire.
Hypersecretion is more common than hyposecretion. Hyperprolactinemia is the most frequent abnormality of the anterior pituitary tumors, termed prolactinomas. Prolactinomas may disrupt the hypothalamic-pituitary-gonadal axis as prolactin tends to suppress the secretion of GnRH from the hypothalamus and in turn decreases the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary, therefore disrupting the ovulatory cycle. Such hormonal changes may manifest as amenorrhea and infertility in females as well as impotence in males. Inappropriate lactation (galactorrhoea) is another important clinical sign of prolactinomas.
The structure of prolactin is similar to that of growth hormone and placental lactogen. The molecule is folded due to the activity of three disulfide bonds. Significant heterogeneity of the molecule has been described, thus bioassays and immunoassays can give different results due to differing glycosylation, phosphorylationsandulfation, as well as degradation. The non-glycosylated form of prolactin is the dominant form at is secreted by the pituitary gland.
The three different sizes of prolactin are:
The levels of larger ones are somewhat higher during the early postpartum period.
Prolactin receptors are present in the mammillary glands, ovaries, pituitary glands, heart, lung, thymus, spleen, liver, pancreas, kidney, adrenal gland, uterus, skeletal muscle, skin and areas of the central nervous system. When prolactin binds to the receptor, it causes it to dimerize with another prolactin receptor. This results in the activation of Janus kinase 2, a tyrosine kinase that initiates the JAK-STAT pathway. Activation also results in the activation of mitogen-activated protein kinases and Src kinase.
Human prolactin receptors are insensitive to mouse prolactin.
Prolactin levels may be checked as part of a sex hormone workup, as elevated prolactin secretion can suppress the secretion of FSH and GnRH, leading to hypogonadism and sometimes causing erectile dysfunction.
Prolactin levels may be of some use in distinguishing epileptic seizures from psychogenic non-epileptic seizures. The serum prolactin level usually rises following an epileptic seizure.
The serum concentration of prolactin can be given in mass concentration (g/L or ng/mL), molar concentration (nmol/L or pmol/L) or in international units (typically mIU/L). The current IU is calibrated against the third International Standard for Prolactin, IS 84/500. Reference ampoules of IS 84/500 contain 2.5g of lyophilized human prolactin and have been assigned an activity of .053 International Units. Measurements that are calibrated against the current international standard can be converted into mass units using this ratio of grams to IUs; prolactin concentrations expressed in mIU/L can be converted to g/L by dividing by 21.2. Previous standards use other ratios.
The first International Reference Preparation (or IRP) of human Prolactin for Immunoassay was established in 1978 (75/504 1st IRP for human Prolactin) at a time when purified human prolactin was in short supply. Previous standards relied on prolactin from animal sources. Purified human prolactin was scarce, heterogeneous, unstable and difficult to characterize. A preparation labelled 81/541 was distributed by the WHO Expert Committee on Biological Standardization without official status and given the assigned value of 50 mIU/ampoule based on an earlier collaborative study. It was determined that this preparation behaved anomalously in certain immunoassays and was not suitable as an IS.
Three different human pituitary extracts containing prolactin were subsequently obtained as candidates for an IS. These were distributed into ampoules coded 83/562, 83/573 and 84/500. Collaborative studies involving 20 different laboratories found little difference between these three preparations. 83/562 appeared to be the most stable. This preparation was largely free of dimers and polymers of prolactin. On the basis of these investigations 83/562 was established as the Second IS for human Prolactin. Once stocks of these ampoules were depleted, 84/500 was established as the Third IS for human Prolactin.
General guidelines for diagnosing prolactin excess (hyperprolactinemia) define the upper threshold of normal prolactin at 25g/L for women and 20g/L for men. Similarly, guidelines for diagnosing prolactin deficiency (hypoprolactinemia) are defined as prolactin levels below 3g/L in women and 5g/L in men. However, different assays and methods for measuring prolactin are employed by different laboratories and as such the serum reference range for prolactin is often determined by the laboratory performing the measurement. Furthermore, prolactin levels also vary factors including age, sex,menstrual cycle stage and pregnancy. The circumstances surrounding a given prolactin measurement (assay, patient condition, etc.) must therefore be considered before the measurement can be accurately interpreted.
The following chart illustrates the variations seen in normal prolactin measurements across different populations. Prolactin values were obtained from specific control groups of varying sizes using the IMMULITE assay.
The following table illustrates variability in reference ranges of serum prolactin between some commonly used assay methods (as of 2008), using a control group of healthy health care professionals (53 males, age 2064 years, median 28 years; 97 females, age 1959 years, median 29 years) in Essex, England:
An example usage of table above is, if using the Centaur assay to estimate prolactin values in g/L for females, the mean is 7.92g/L and the reference range is 3.3516.4g/L.
Hyperprolactinaemia, or excess serum prolactin, is associated with hypoestrogenism, anovulatory infertility, oligomenorrhoea, amenorrhoea, unexpected lactation and loss of libido in women and erectile dysfunction and loss of libido in men.
Hypoprolactinemia, or serum prolactin deficiency, is associated with ovarian dysfunction in women, and arteriogenic erectile dysfunction, premature ejaculation,oligozoospermia, asthenospermia, hypofunction of seminal vesicles and hypoandrogenism in men. In one study, normal sperm characteristics were restored when prolactin levels were raised to normal values in hypoprolactinemic men.
Hypoprolactinemia can result from hypopituitarism, excessive dopaminergic action in the tuberoinfundibular pathway and ingestion of D2 receptor agonists such as bromocriptine.
While there is evidence that women who smoke tend to breast feed for shorter periods, there is a wide variation of breast-feeding rates in women who do smoke. This suggest that psychosocial factors rather than physiological mechanisms (e.g., nicotine suppressing prolactin levels) are responsible for the lower rates of breast feeding in women who do smoke.
Prolactin is available commercially for use in animals, but not in humans. It is used to stimulate lactation in animals. The biological half-life of prolactin in humans is around 1520 minutes. The D2 receptor is involved in the regulation of prolactin secretion, and agonists of the receptor such as bromocriptine and cabergoline decrease prolactin levels while antagonists of the receptor such as domperidone, metoclopramide, haloperidol, risperidone, and sulpiride increase prolactin levels. D2 receptor antagonists like domperidone, metoclopramide, and sulpiride are used as galactogogues to increase prolatin secretion and induce lactation in humans.
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Prolactin – Wikipedia
If you are feeling out of balance, tired and overwhelmed, or your quality of life is being compromised by the symptoms of aging, don’t despair. Your body and hormones are simply trying to give you a wake-up call. There is plenty you can do to feel energetic, vibrant and healthy again.
The medical team at Westcoast Women’s Clinic are specially trained hormone physicians and experts in helping women achieve optimal health and wellness during their midlife years, which can range from their late-30s to mid-60s.
We also offer programs for Young Women and Male patients to optimize hormone health.
Our Comprehensive Hormone Health Program includes state-of-the-art hormone testing, bioidentical hormone therapy, mind/body medicine, nutritional supplements and lifestyle modifications. Every treatment program is fully customized, from the bioidentical hormones to the physical, emotional and spiritual recommendations, to help ensure individual success.
Our Hormone Health program is an effective way to manage:
Personalized Solutions For Wellness & Vitality
Hormones control everything in your body. At any age, our hormones can begin to decrease causing low energylevels, fatigue, trouble sleeping, trouble losing weight, mood swings, depression and low libido. Our providers haveover 100 years of combined clinical experience specializing in Bioidentical Hormone Replacement Therapy and Medical Weight LossPrograms.
Do you experience hormone imbalance symptoms such as:
Have you been informed by your doctor that you have normal blood test results or that its all in your head? We want you to have the energy and ability to experience life to its fullness. Natural Bio Healths focus is to help each patient gain control of their individual health. Dont wait this is the first step to getting your life back!
Congratulations on taking charge of your health! The first step is a phone consultation with a wellness consultant who will guide you through the process of becoming part of the Natural Bio Health Family and to schedule your appointment.
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Medical Weight Loss | Endocrinology & Hormone Replacement
What is natural hormone replacment and why consider it an option for you?
Natural hormones are biologically identical to the hormones your body makes. Meaning, the chemical structures of the hormones are identical to those synthesized in your ovaries and other areas of the body. The body sees Prempro and Premarin and considers them foreign substances, but it recognizes bioidentical hormones as familiar and responds to them in natural ways.
Dosages are customized to each patient. One size does not fit all. Each patient is put on a dose specifically chosen according toindividualhormone levels, symptoms, genetic profile, stress level, and overall health assessment.
Since the product is compounded at special pharmacies, any dose of any hormone can be added, subtracted, and adjusted as appropriate. This is individualized hormone replacement therapy, which takes into account the fact that all women and men are not the same.
There are multiple modalities of administering natural hormones: creams, gels, sublingual drops, injections, capsules, hormone pellet implants.
All the benefits of hormone replacement therapymood, sex drive, heart, brain, bone density, and cancer protectionapply to natural hormone replacement without clinical evidence of the well documented side effects of the chemicalized, horse urine, conjuguated estrogens contained in conventional hormone replacement therapy (HRT).
What is the difference between bioidentical and chemical/synthetic hormones?
1.) Mixture of horse urine-based, chemicalized synthetic estrogens (equilin, equilinin, etc.) plus additives and coatings, which are also synthetic.
2). Can remain in the body for as long as 13 weeks.
3.) Potency of synthetic estrogen is approximately 200 times that of natural estrogen.
4.) Contains higher percentage of more aggressive types of estrogen.
5.) One-size-fits-all dosing.
1.) Bioidentical replaces instead of substituting an unfamiliar chemical.
2.) Eliminated from the body in a matter of hours, not weeks.
3.) Potency is same or even less than estrogen levels in ovulating women.
4.) Customized treatment program.
5.) Physiologic doses used.
6.) All of the bodys other hormones are evaluated and treated simultaneously, to keep natural balance intact (DHEA, cortisol, testosterone, progesterone, thyroid hormones, insulin, etc.)
7.) Diet /nutrition, exercise, stress control, digestion, and detox are equally important parts of treatment.
Its not the estrogen you take that causes breast cancer , but the estrogen you make. We now know that estrogen converts into other forms (metabolites), which determine the ultimate effects of estrogen on your body.
It appears to be the metabolites of estrogen that determine the risk of developing breast cancer. (Metabolite: The product of the chemical changes a substance undergoes in the tissues.)
There are three signifcant metabolites of estrogen that determine cancer risk:
The first is 2-hydroxy estrone (good for you). It does not stimulate cell division and it attaches to estrogen cell receptors and blocks attachment of more aggressive estrogens.
The second is 16-hydroxy estrone (bad for you). This one strongly attaches to receptors and stimulated DNA synthesis and cell replication. It binds permanently to receptors, while other estrogens attach briefly and are released.
The third metabolite is 4-hydroxy estrone (also bad). May directly damage DNA and can cause mutations that are carcinogenic.
Equine estrogens (Premarin, Prempro) promote metabolism of the 4-hydroxy estrones, causing mutagenic damage (cancer potential) five times more rapidly than human 4-hydroxy estrones.
Too high (or low) doses of ANY type of hormone (hormone imbalance) will cause undesirable sideeffects. Natural HRT is prescribed at the lowest effective doses, and treatment is followed with regular lab tests (blood, saliva, urine), uterine ultrasounds, breast exams, mammograms/thermograms, pap smears, and regular visits to the physicians office.
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Hormone Replacement Therapy | Born Clinic
National Guideline Clearinghouse
The National Guideline Clearinghouse (NGC), an AHRQ initiative, is a publicly available database of evidence-based clinical practice guidelines and related documents. Updated weekly with new content, the NGC provides physicians and other health professionals, health care providers, health plans, integrated delivery systems, purchasers, and others an accessible mechanism for obtaining objective, detailed information on clinical practice guidelines and to further their dissemination, implementation, and use.
Created in 1984, the U.S. Preventive Services Task Force (USPSTF or Task Force) is an independent group of national experts in prevention and evidence-based medicine that works to improve the health of all Americans by making evidence-based recommendations about clinical preventive services such as screenings, counseling services, or preventive medications. The USPSTF is made up of 16 volunteer members who come from the fields of preventive medicine and primary care, including internal medicine, family medicine, pediatrics, behavioral health, obstetrics/gynecology, and nursing. All members volunteer their time to serve on the USPSTF, and most are practicing clinicians.
The Guide to Clinical Preventive Services includes U.S. Preventive Services Task Force (USPSTF) recommendations on screening, counseling, and preventive medication topics and includes clinical considerations for each topic. This new pocket guide is an authoritative source for making decisions about preventive services.
Between 1992 and 1996, the Agency for Health Care Policy and Research (now the Agency for Healthcare Research and Quality) sponsored development of a series of 19 clinical practice guidelines. These guideline products are no longer viewed as guidance for current medical practice, and are provided for archival purposes only.
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Clinical Guidelines and Recommendations | Agency for …