Archive for the ‘Male Genetics’ Category

The idea is if we dont look out the white race will bewill be utterly submerged. Its all scientific stuff; its been proved.

These are not the words of the teenager who walked into a supermarket in Buffalo, New York, on Saturday to hunt down Black Americans, although they might as well be. These are the words of Tom Buchanan, a rich, repugnant character in the 1925 novel The Great Gatsby.

Shortly before the massacre in Buffalo, authorities say, the shooter published a 180-page document that is an unpleasant mixture of the disconcertingly new and the horribly familiar. Underneath the superficial novelty of the suspects alleged actions (livestreaming the atrocity on Twitch, publishing the manifesto on Google Docs) and his vocabulary (his complaint about buying a cucked assault rifle that he had to modify, for example) is a sprawling, discredited ideology that was once entertained by respectable people and has now crept back toward the mainstream.

Graeme Wood: Why Tucker Carlson should want the Buffalo manifesto made public

The manifesto is steeped in early-20th-century scientific racismwhich motivated Gatsbys Buchananand the anti-Semitism that so often accompanied it. The document contains pages of memes about Jewish control of the world, plus scientific-looking scattergraphs of IQs broken down by racial group. Call this the intersectionality of hate: Just as academics have pointed out that marginalized identities (race, class, sex, disability) can overlap and reinforce one another, so too can old hatreds. Far-right movements are flexible about identifying the other from which their adherents are supposedly under threat. Many fascists see liberated women as a symbol of social decadence and decline. The KKK also targeted Jews. That an anti-Black racist like the Buffalo shooter would also be in thrall to anti-Semitic tropes might seem surprising, but intersectional hate is a totalizing ideology. Every new talking point is woven into the same tapestry, in which white men are at the center, protecting their women, and everyone else is at the margins.

The Buffalo shooter is open about the source of his radicalization. It was the internet, and specifically an anonymous discussion board on 4chan. There I learned through infographics, shitposts, and memes that the White race is dying out, he writes. He distributes the blame among Black Americanswhom he depicts as violent and lazyand the Jews and the elite who control them.

Although he doesnt mention them by name, the shooters grievance also lies with white women, through his invocation of falling birth rates and the Great Replacement, a conspiracy theory that accuses left-wing politicians of encouraging immigration to undermine majority white, Christian societies and create new, obedient voter bases. In his mythology, Black Americans are among the replacersa dehumanizing term repeatedly invoked in the documentwhile the masterminds of the replacement are Jews. This is one example of how hatreds amplify one another: If Black Americans are so inferior, how can they be a threat to the glorious white race? Ah, because they are being directed by shadowy puppet masters. And which group has been cast in this role throughout history? The Jews.

Yair Rosenberg: Why so many people still dont understand anti-Semitism

Although the American strain of white supremacy is distinctive, recent terrorists have been influenced by many overlapping ideas. The man who massacred 51 people at a New Zealand mosque in 2019 subscribed to the European version of Great Replacement theory, in which the demographic attack comes from Muslims, and Jews do not prominently feature. The gunman who killed 23 people at a Walmart in El Paso, Texas, the same year released a manifesto warning of a Hispanic invasion. The man who set fire to a mosque and shot four people in a synagogue in Poway, California, insisted in his own screed that Jews deserved to die for their role in feminism which has enslaved women in sin.

The ideology might be flexible, but it always returns the same answer: The West is in decline; the white race is under threat, and it must be protected by violence. In place of the messy truth that migration is a continuous churn driven by war, famine, and individuals desire for a better life, the Great Replacement suggests a coherent plan controlled by knowable forces. Such theories thrive in hard times, because they offer themselves as an antidote to chaos.

In the late 19th and early 20th century, Francis Galton and other then-respected scientists talked earnestly about classifying humans into superior and inferior races. Galtons heirs used the new technology of the IQ test, originally developed to identify children struggling at school, to collect proof of the alleged superiority of Europeans. Their work depended on definitions of whiteness, and rigid racial categories, that have since been debunked. (At various times in American history, Polish, Irish, and Italian immigrants would not have been considered white in the same way as those of Nordic stock.) Todays geneticists know better than to build their work on such shifting sands.

Nevertheless, the blithe assertions of early eugenicists and scientific racists are now being recast, a century later, in the clunky visual style of the modern internet, with its homemade cut-and-paste jobs of text overlaid on graphics. The anti-Semitic tropes in the Buffalo shooters manifesto could come straight from The Protocols of the Elders of Zion, a fabricated text about a minority with disproportionate powers to control the world, or Henry Fords Dearborn Independent. But these ideas are presented in picture form. Page after page identifies people who hold important jobs as Jews; readers are left to form their own (predestined) conclusion. Also included are tables of supposedly Jewish facial features that could have come straight from a 19th-century phrenology handbook. Hes saying something that Ive never seen so clearly expressed before, Adam Rutherford, a British geneticist who writes about scientific racism, told me. He was radicalized by infographics.

Kathleen Belew: White power, white violence

The slapdash, collage style of the manifesto is the true novelty here; the author discusses his underwear, his lunch plans, and his Myers-Briggs profile alongside his murderous hatred of Black Americans, Jews, and other races. This format underscores how todays terrorists tend to radicalize themselves, alone, at home. They are technically lone wolves but are in constant dialogue with the internets bleakest corners. The blizzard of facts and figures on far-right websites flatters them into thinking they have followed a trail of clues and arrived at the truth themselves, unlike the blinkered herd. It is a narcissistic fantasy that casts the young radical as the hero of his own questa detective story in which he is an active participant. Many mass shooters have a sense of grievance in search of a mythology. The manifestos author claims that he found communism at age 12 but rejected it when he found something more useful to his psychological needs.

Rutherford, the author of the book How to Argue With a Racist, studies how academic research into intelligence and population genetics is laundered for use on white-supremacist websites. He cites the example of a mainstream paper on inheritance that featured a scatterplot on characteristics of people of Jewish descent, and ended up in racist internet posts. The simple addition of group labels such as quadroon Jewsa term repurposed from Jim Crowera Americatransformed a careful scientific study into a piece of racist propaganda. This is using science to prop up a preexisting ideology. Its exactly what happened in the 1900s with the [genetics] work of Gregor Mendelthe eugenicists seized on it, Rutherford said. Its the same as it ever was. New techniques, old story.

People drawn to intersectional omni-hatred can find multiple on-ramps online. One way into this mindset is through tasteless jokesmany users of sites such as 4chan see mocking the Holocaust as thrillingly transgressive. But ironic anti-Semitism expressed for shock value can shade into overt, unironic anti-Semitism expressed as a genuine belief. Another on-ramp is the debate, now simmering for more than a century, about the supposed connection between race and intelligence. Modern geneticists are reluctant to make sweeping statements about populations, but their nuanced disputes about the influence of environment versus heredity are presented instead by the far right as the left-wing suppression of obvious but unspeakable facts. (The resurgence of scientific racism as a political force poses a challenge to genetics researchers, many of whom would prefer to dodge these controversial questions altogether but risk leaving the field clear for cranks.)

Adam Serwer: Demography is not destiny

Anti-feminism is also a route to the far right. Nearly all mass shooters are men, and the tone of many far-right sites assumes that all their readers are male. White women mainly exist in this ideology to be protected from rape by invaders or from their own desire to have children with nonwhite men. Feminism is a threat because it frees women from mens economic control and might encourage them to pursue careers at the expense of motherhood. The Buffalo shooter invoked a white-supremacist slogan: We must secure the existence of our people and a future for white children. The we are white men, framed as soldiers and martyrs, posing as the heroic defenders of the weak. A power fantasy is baked into this ideology, but so is feara clammy horror of becoming redundant and obsolete.

In the 1920s and 30s, a prominent man could voice his discriminatory thoughts about inferior races and the international Jew out loud, in public; Gatsbys fictional Buchanan had real-life counterparts in Ford and Father Coughlin. In the century since, pseudoscientific racism has been driven to the margins of society and appears instead in watered-down forms, in allusions, winks, and dog whistles. (Especially after the Buffalo shooting, the Fox News host Tucker Carlson has been widely criticized for promoting the Great Replacement theory. But as my colleague Graeme Wood notes, Carlson could not keep his job if he presented it in the grotesque terms expressed in the shooters manifesto.) Yet the banishment of overt scientific racism from the public square has given it a new glamour online, where it marinates alongside other forms of hatred and draws adherents who convince themselves that urgent truths are being suppressed. That mindset allows young men to brick themselves inside a mental castle of half-truths and old lies, fed by their own sense that they deserved better, and they could be remembered as a hero, if only they picked up a gun.

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The Intersectionality of Hate - The Atlantic

Complete mitochondrial genome assembly

The mitogenomes of St, Sc, and StSc were assembled into five to two subgenomes through de novo assembly using 5.3 to 6.6Gb PE reads. Each assembly was validated by conducting PCR analysis and sequencing (Tables S1 and S2, Fig. S1). The St mitogenome size was 756,058bp, and it was composed of five circular subgenomes of lengths 49,230 to 297,014bp. The total number of non-redundant genes was 78, consisting of 37 PCGs, 19 ORFs, 3 rRNAs, and 19 tRNAs (Table 1, Fig. S2A). The Sc mitogenome was 552,103bp in size with two subgenomes (338,427 and 213,676bp). The total number of non-redundant genes was 77, consisting of 37 PCGs, 20 ORFs, 3 rRNAs, and 17 tRNAs (Table 1, Fig. S2B). The StSc mitogenomes were 447,645bp in size with a major circular DNA of 398,439bp and a minor subgenome of 49,206bp. The total number of non-redundant genes was 77, consisting of 37 PCGs, 20 ORFs, 3 rRNAs, and 17 tRNAs (Table 1, Fig. S2C).

A total of 71 genes were shared among the three mitogenomes. Some genes were unique in each mitogenome: four ORFs (orf131, orf 190, orf 240, and orf 279), and three tRNAs (trnI-GAU, trnL-CAA, and trnV-GAC) were unique in the St mitogenome; five ORFs (orf109d, orf111, orf140, orf185, orf240) and one tRNA (trnfM-CAT) were unique in the Sc genome; and five ORFs (orf111, orf127, orf131, orf140, orf185) and one tRNA (trnV-GAC) were unique in the StSc mitogenome (Table 2).

Mitochondrial plastid DNA (MTPT) has been reported in various plants, such as Amborella trichopoda, Zea mays (maize), and Cynanchum wilfordii34,35,36. The degree of MTPT was examined by sequence comparison with the S. tuberosum plastome sequence (GenBank accession No. no. KM489056)37. Consequently, the St, Sc, and StSc mitogenomes were approximately 1.08.0%, 2.98.0%, and 3.14.0% considered as MTPT, respectively. Overall, approximately 1.08.0% were identified as MTPT (Table 1, Fig. S2).

Further, nuclear mitochondrial DNA (NUMT) has also been reported in various plants, such as Arabidopsis thaliana and Cucumis sativus (cucumber)38,39. NUMT was identified by sequence comparison with the S. tuberosum nuclear genome sequence (SolTub_3.0, https://www.ncbi.nlm.nih.gov/assembly/GCF_000226075.1/). Consequently, the St, Sc, and StSc mitogenomes were approximately 17.257.7%, 16.117.4%, and 10.116.3%, respectively, which were considered to be derived from or transferred to nuclear genomes accordingly. Overall, approximately 10.757.7% was identified as NUMTs. A total of 57.7% was identified in St subgenome 4, which has a very small genome size (Table 1, Fig. S2).

Homologous recombination (HR) can be mediated by repeat sequences in St, Sc, and StSc mitogenomes. The St, Sc, and StSc mitogenomes accounted for approximately 2.219.4%, 4.821.3%, and 5.725.9% of repeat sequences in which the repeat ratio was also positively correlated with the subgenome size (Table 1, Figs.1 and S2). The five St subgenomes exhibited diverse numbers of dispersed repeats: 300 (mitogenome coverage: 19.4%), 211 (15.2%), 41 (5.5%), 18 (2.2%), and 39 (4.9%) in each subgenome (Tables 1 and S5, Figs.1A and S2A). The two Sc subgenomes included 460 (25.9%) and 198 dispersed repeats (15.2%) (Tables 1 and S5, Figs.1B and S2B). Further, the two StSc subgenomes contained 480 (21.3%) and 39 (4.8%) dispersed repeats (Tables 1 and S5, Fig.1C and S2C). In contrast, tandem repeats were selected with adjacent sequences of at least two copies and up to 50bp. The St, Sc, and StSc mitogenomes had only 17, 20, and 16 tandem repeats, respectively (Table S6).

Chord diagram of three Solanum mitogenomes. (AC) represent the homologous regions of the subgenomes. R1 to R3 represent the large repeats that might cause homologous recombination among the corresponding subgenomes. St: S. tuberosum accession no. PT56, Sc: S. commersonii accession no. Lz3.2, StSc: somatic hybrid accession no. HA06-9.

Two large repeats (more than 1kb) were identified in the St subgenome 1. R1 was 11,916bp, and R2 was 7500bp. In contrast, St subgenome 2 had only R1, and subgenome 3 had only 1589bp of R3. Similarly, the R1 sequence co-existed in St subgenomes 1 and 2. The R2 repeat is shared between subgenomes 1 and 4 (Table S5, Figs.1 and S2), which might contribute to the HR between different subgenomes. The Sc mitogenomes had two multipartite structures, in which three large repeats of more than 1kb were identified (R1: 16,857bp, R2: 10,094bp, and R3: 1024bp), which might contribute to recombination events between subgenomes (Table S5, Figs.1 and S2). The StSc mitogenomes contain four large repeats (more than 1kb) (R1, 11,916bp; R2, 11,846bp; R3, 1643bp; and R4, 1024bp) that might contribute to subgenome reshuffling (Table S5, Figs.1 and S2).

We compared plastomes, mitogenomes, and nrDNAs among St, Sc, and StSc genomes. The StSc plastome was identical to Sc plastome37. Meanwhile, the StSc mitogenome shows a complicated structure with unique genes derived from both species (Table S3, Fig.2). Among 71 common genes, 21 PCGs (nad3, nad4, nad4L, nad5, nad6, sdh3, cox2, cox3, atp1, atp4, atp8, atp9, ccmB, rps3, rps4, rps12, rps13, rpl5, rpl10, rpl16, and mttB) were found identical across the three mitogenomes (denoted as green boxes on Fig.2) and their origin in the StSc genome could not be determined; 12 PCGs (nad1, nad2, nad7, nad9, sdh4, cob, cox1, ccmC, ccmFc, rps10, rpl2, and matR) were found identical with Sc (represented as sky-blue boxes in Fig.2) and 2 PCGs (atp6 and ccmFN) were identical with St (pink boxes in Fig.2). Therefore, it is likely that the majority of the somatic hybrid mitogenomes originated from Sc (Fig.2).

The origin of mitogenome recombination block in somatic hybrid (StSc) (A) Subgenome 1 of somatic hybrid mitogenome (B) Subgenome 2 of somatic hybrid mitogenome. The pink and sky-blue triangles on the black middle line indicate genes derived from S. tuberosum and S. commersonii, respectively. The green diamond boxes indicate genes of unknown origin.

GISH data using Sc genome probes revealed strong signals in 24 chromosomes but weak signals in the other 24 chromosomes in the StSc somatic hybrid (Fig.3A). We also assembled and compared 45S nrDNA cistron sequence of three species. For example, multiple aligned position at 191bp represents T genotype in St and C genotype in Sc. However, in StSc, it was identified that 75.6% of T and 24.4% of C were present. In conclusion, the overall 45S nrDNA sequences of StSc revealed both genotypes with average about 70 and 30 ratio for Sc and St, respectively (Fig.3B).

Detection of nuclear genome fusion in somatic hybrid. (A) GISH analysis of somatic hybrid (HA06-1 clone) using S. tuberosum specific-probes. The red signal of 24 arrows indicates the S. commersonii nuclear subgenomic distribution. (B) Schematic diagram of 45S ribosomal DNA cistron of Solanum species. StSc summary represents the percentage of St or Sc genotypes in the 45SnrDNA sequence.

In summary, St, a dihaploid of tetraploid cultivated potato, has five mitogenomes. Sc, a diploid wild potato, has two mitogenomes. Somatic hybrids developed via protoplast fusion of these two diploids contain the Sc-unique plastome37 but recombined mitogenomes and nuclear genomes derived from both St and Sc genomes (Fig.4).

Schematic diagram of mitogenome in parental species and their somatic hybrids. (A) S. tuberosum (St), (B) S. commersonii (Sc), and (C) somatic hybrid (StSc). S. tuberosum and S. commersonii have five and two subgenomes, respectively, which are fused into two subgenomes in the somatic hybrid generated by protoplast fusion. The origin of chloroplast genome in somatic hybrid has been determined based on sequence comparison among chloroplast genome sequences of parental species and that of the somatic hybrid.

A total of 35 PCGs were common across Solanaceae. The nonsynonymous substitution (Ka), synonymous substitution (Ks), and their ratios were calculated. The Ka values ranged from 0 to 0.119 with a 0.003 of median value. The nad4 and nad4L genes had the lowest Ka values, while atp6 had the highest Ka value. The Ks values ranged from 0.02 to 0.228 with a 0.01 of median value. Moreover, mttB and atp6 had the lowest and highest Ks values, respectively. Lastly, the Ka/Ks values ranged from 0 to 3.528 with a median value of 0.286 (Table S8, Fig.5A). A Ka/Ks value of more than 2 was observed due to the extremely low Ks value.

Mitochondrial gene diversity in Solanaceae family. (A) non-synonymous substitution (Ka) and synonymous substitution (Ks) values among the 12 Solanaceae species. Ka and Ks values were calculated with 35 protein-coding genes by CodeML program. (B) Variations of atp6 are shown by the phylogenetic tree and multiple comparisons of amino acid sequences. The conserved domain has been determined through NCBI BLASTP search.

Although the Ka and Ks values were generally low, ccmFc and mttB exhibited high Ka/Ks values of more than 1, indicating that these genes were positively selected during evolution (Fig.5A). Considering that atp6 showed a high mutation rate above 0.1. Ka and Ks values relative to the other genes, the amino-acid sequences corresponding to atp6 were compared among Solanaceae species, which revealed that amino acid sequences were variable at the N-terminus but conserved at the C-terminus (Fig.5B).

Phylogenetic trees were constructed using various programs, including RAxML, MEGA7, PhyML, and BEAST to examine the topology of the species. Trees treated with RAxML, PhyML, and BEAST displayed the same topology, while those treated with MEGA7 exhibited slightly different topologies (Fig. S3). In trees generated using RAxML representing an optimized topology (Figs.6 and S3), Solanaceae species were divided into two subfamilies, Solanoideae and Nicotianoideae, and the somatic hybrid exhibited a moderate branch between St and Sc. During the evolution of Solanaceae mitogenome, first, rps1 and rps19 were present in Solanaceae, however, these were omitted completely in Oleaceae. Next, rps7 was confirmed to be completely deleted in Solanaceae compared to Oleaceae. Lastly, ycf14 in all Nicotianoideae species was pseudogenized in the divergence period between Solanoideae and Nicotianoideae (Fig.6).

Phylogenetic relationship of 13 Solanaceae species using 35 protein-coding gene sequences commonly conserved in mitogenomes. The maximum likelihood tree was constructed using RAxML program with GTR++I model (based on jModelTest2) and a bootstrapping value of 1000. The bootstrap value (>=0.5) is shown on the node. Deleted genes and pseudogenes specifically within each group in the tree have been also shown by red and black boxes, respectively. Olea europaea in the Oleaceae family has been used as an out-group.

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Mitochondrial genome recombination in somatic hybrids of Solanum commersonii and S. tuberosum | Scientific Reports - Nature.com

AUTHOR:Scott T. Vergano, MDDepartment of Pediatrics, Childrens Hospital of The Kings Daughters, Norfolk, VA

CITATION:Vergano ST. Top papers you may have missed in April 2022. Consultant360. Published online May 18, 2022.

A policy statement this month is so important that I have chosen to focus most of my commentary on it. In addition, I note several other relevant publications that appeared in the month of April.

Please feel free to share with your colleagues, discuss in your offices, and write toeditors@consultant360.comwith your thoughts and opinions. As always, I am interested in hearing your thoughts and responses.

Here are my selections:

Health Supervision for Children and Adolescents With Down Syndrome1 The most important publication this month is this update to the 2011 Academy of Pediatrics (AAP) guidance on Health Supervision for Children With Down Syndrome. I read and reference this policy statement every time I do a check-up for a patient with Trisomy 21 and often give it out to families as well. (In my old paper charts, it was stapled to the inside of the front of the chart.) Here are the most significant changes that I notice compared with the previous statement:

The AAP Council on Genetics has issued equally valuable guidelines on health supervision for numerous other genetic conditions, in addition to Trisomy 21. The disorders covered by current policy statements include achondroplasia, Williams syndrome, neurofibromatosis type 1, and Marfan syndrome.

Childhood Cardiovascular Risk Factors and Adult Cardiovascular Events2

The authors of this multinational prospective study follow 38,589 participants over a mean of 35 years and record 319 fatal and 779 fatal or non-fatal cardiovascular events in adulthood. They identify 5 childhood cardiovascular risk factors: body mass index, systolic blood pressure, total cholesterol level, triglyceride level, and youth smoking, and examine whether these risk factors are predictive of fatal and non-fatal cardiovascular events in adults. After calculating a z-score for individual and combined risk factors, they conclude that risk factors identified in childhood are positively associated with mid-life cardiovascular events. The strongest association is noted with youth smoking and the weakest with total cholesterol level.

Crossing LinesA Change in the Leading Cause of Death among U.S. Children3This editorial from theNew England Journal of Medicine (NEJM) notes that the leading cause of death in children in the United States from ages 1 to 24 years has changed since 2017; it is now firearm-related injuries and no longer motor vehicle collisions (MVCs). The change is related to both a decrease in MVCs and an increase in firearm-related deaths, particularly homicides and suicides in older patients within the cohort. Two comments posted on the NEJM website criticize choosing an unconventional definition of children to make the statistics justify the conclusion.

Annual STI Testing Among Sexually Active Adolescents4

The addition of a question about sexually transmitted infection (STI) screening on the biennial national Youth Risk Behavior Survey administered in schools enabled the authors of this publication inPediatricsto assess the frequency of STI screening among adolescents who acknowledge having sex within the last 3 months. They find that 26.1% of sexually active female students and 13.7% of male students report having been tested for STIs in the previous year. They conclude that adherence with guidelines for STI screening among adolescents appears suboptimal. Current national guidelines recommend annual screening for gonorrhea and chlamydia in sexually active adolescent females and males who have sex with males, but not in all adolescent males.

References:

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Top Papers You May Have Missed in April 2022 - Consultant360

According to a February 2022 Gallup poll that should have been far bigger news than it was, a whopping 20 percentone in five, that isof Generation Z American adults (born 1997-2003) now identify as LGBTQ. That trend shows a sharp upward slope with every successive generation. In fact, LGBTQ identification has roughly doubled with each new generation: The respective numbers for millennials (born 1981-1996), Generation X (born 1965-1980), baby boomers (born 1946-1964), and those born before 1946 are 10.5 percent, 4.2 percent, 2.6 percent, and 0.8 percent. Looking at Americans as a whole, 7.1 percent of us now identify as LGBTQ, double the 3.5 percent who so identified in 2012, not so very long ago.

The identitarian advocates take on this development will undoubtedly be that it reflects nothing more than growing freedom, the growing openness within a previously repressive society to once-suppressed modes of sexual expression. It was always the case, that narrative would go, that some 20 percent of us, or perhaps even more, had non-traditional sexual preferences, but society used to force all but the boldest and most determined into a single narrow lane. Sexual preference, after all, is biologically determined and not a choice, as we are repeatedly told by advocates.

That narrative, I would suggest, is patently absurd. It is itself the result of a pernicious mode of suppression, the suppression of speech and science that would point in a different and more obvious direction. The reality, as history and science convincingly demonstrate, is that human sexuality is highly malleable and amenable to social cues, norms, and proscriptions.

Take a case in which the range of acceptable sexual practices has narrowed rather than broadening over time, namely, the age of consent. In the ancient and medieval world, marriage largely tracked biological maturity. Girls could be married, often to significantly older men, at tender ages such as 14 or 15, if not younger. The acceptable marriage age was 12 in ancient Rome, for instance, a practice echoed by the guidance of the Catholic Church in medieval times. A piece of progressive legislation in England in 1875 raised the age of consent to sexual relations for girls from 10 to 13. Our present-day norms shifting such matters to the late teen years are, historically speaking, a blip on the screen.

Does this mean, following the logic of LGBTQ advocates, that it is normal and natural for grown men to be attracted to and have sexual relations with barely post-pubescent girls and that only the force of legal repression and social taboos is keeping such desires from manifesting themselves en masse? Not at all, I would argue. Rather, most of us are amenable to a range of sexual practices. We respond to environmental and social conditioning, particularly during certain critical periods of our maturation. We react to what we are told and to what we see all around us in America today, whether in images and videos or among our elders and our peers. And the result is that most of us, in contrast to our ancestors, are genuinely not attracted to young teens. We find the prospect repugnant for much the same reason that those raised in cultures in which insects, dogs, or fellow humans are not eaten are generally repulsed by even the notion of such consumption, while these may be perfectly natural and even relished foodstuffs for those who came of age in other societies.

Take a few other examples closer to the topic at hand. We know that it was not uncommon for ancient Greek men to engage in the practice of pederasty, i.e., to be both married to their wives and, at the same time, to take on boys in their mid-teen years to enjoy carnal relations while simultaneously providing mentorship to their younger brethren. In Melanesia, among the Etoro people, boys drinking of the semen of their elders is a coming-of-age ritual, and homosexuality is the norm, interrupted by brief periods of heterosexuality, which is considered sinful;among the Marind-anim, husbands routinely engage in sexual relations with their sisters adolescent sons, while wives engage in ritualized sex in groups. What the existence of these various practices, and more like them throughout the world and throughout history, should be sufficient to show is that human sexual preferences are relatively fluid and largely determined by governing norms rather than innate biology.

We might also consider in this connection a less controversial example demonstrating how our own sexual preferences have drifted over time in the West. We can observe this by looking at changing images of female beauty across many centuries, or we can simply think back to more recent American history: While the present-day ideal is more curvy and athletic, the waif supermodel look constituted our ideal just a few decades ago. Surely we do not believe that the heterosexual male brain, over the course of these years, underwent genetic changes sufficiently significant to alter our fundamental desires. Rather, we responded to social currents that substantially shifted those core desires.

Turning from history and anthropology to science, the search for the advocates holy grail, the gay gene, has consistently come up empty. In fact, a massive 2019 study that correlated the genomes and sexual practices of some half a million people in the U.S. and Europe found not only that no single gene predicted homosexuality but that even the five most seemingly salient genetic markers accounted for less than 1 percent of the differences among reported sexual preferences. When researchers then looked at overall genetic similarity among those who reported having same-sex experiences, genetics accounted for only between eight and 25 percent of the outcome. Clearly, in other words, some mysterious combination of the sum-total of social and environmental factors is doing the brunt of the work.

We have strongly suggestive evidence, moreover, that social cues can play causal roles in swaying impressionable teens to adopt new sexual identities. A much-discussed 2018 study from Brown University professor, physician, and researcher Lisa Littman looked at 256 teens who had suddenly come out as transgender after a childhood with no sign of gender dysphoria. Among 86 percent of those teens, the majority of whom had had at least one other mental disorder, the coming out moment was preceded by increased use of social media and/or multiple friends having come out shortly before. Just as tellingly, a large number of studies have confirmed that between 60 percent and 90 percent of kids and teens who think they are transgender grow up, if their bodies have not been altered by surgery and hormones in the interim, to be adults who no longer want to transition (and, instead, usually turn out merely to have same-sex mate preferences).

The simple message such research conveys is something that those of us who have not lost touch with our childhood and our awkward teen years will find unsurprising, and indeed, even obvious: Most kids and teens are works in progress and undecided and confused about many key aspects of their lives. The realm of sexuality, mysterious and alien to the domain of childhood experience, both by nature and by design, falls for many into that undecided and confused category. There is no question that some kids are very clearly straight from the get-go, and others are just as clearly and decidedly gay. But there are likely many children and teens who fall somewhere between the poles, a likely reason why even among those in Generation Z who identify as LGBTQ, more than half place themselves in the uncommitted category of bisexual. Just as the rest of what will become our more-or-less abiding tastes in life are in flux and in the process of congealing, our likes and dislikes when it comes to all things sexualwhat we find desirable as far as body types, personality types, fantasies, fetishes and, yes, even heterosexual, homosexual, or other core sex and gender preferencesmay be in varying states of limbo during these tender years.

Complex interactions between our particular biologies, personalities, and environments are going to matter a great deal in determining ultimate outcomes. Imagine, for example, a naturally rebellious kid growing up in an environment in which coming out as trans is the cool, new, outr trend sweeping the nation, offering an opportunity to poke a thumb in the eye of bewildered parents and other elders. Or imagine a sensitive, weak-willed soul craving social approval and finding good friends around her coming out as lesbian or bi-curious. Now imagine these same kids coming of age in a society where deviations from the traditional heterosexual norm are rarities. Here, unless that rebellious kid is really rebellious, we might get a different outcome.

Much of the nuance inherent to this discussion gets routinely swept away when we pose the problem as a false, politicized dichotomy between biological determinism and individual free choice. The American Psychological Association, for instance, warns us sternly that psychologists do not consider sexual orientation to be a conscious choice that can be voluntarily changed. At least the first part of that proposition is likely true in most cases (and the second part is true for most as well, if what is envisioned is a voluntary change to be made on a dime), but it is a dodge rather than a revelation. There is probably no single moment when an individual chooses to become attracted to members of the same sex any more than there is a moment when we choose to become attracted to redheads. And yet in no way does that imply that we are born with a thing for redheads.

We, as individuals, may not make such choices, but we, as a society, certainly do. As the evidence drawn from other societies across the world and throughout history shows us, the examples we set, the images we project, the information and education we convey, the manner in which we organize our lives and our institutions, all of these will bear upon the prevalence of LGBTQ lifestyles in our midst. We cannot evade our responsibility. It is for us to choose the society in which we want to live.

* * *

In contemplating our options and asking ourselves whether an America in which 20 percent or more of a rising generation identifies as LGBTQ is the America we want, we might consider the following. In a phenomenon characterized by some as The Mystery of the Declining U.S. Birth Rate, our birth rate as of 2020 was 55.8 births per 1,000 women of childbearing age, a steep drop of about 15 percent from 2007, when that number was 69.3 per 1,000. Much of this alleged mystery is solved when we consider the revolution and exponential increase in LGBTQ acceptance and LGBTQ lifestyles that occurred over roughly the same period. Support for same-sex marriage, for example, stood at a meager 27 percent of Americans in 1996 and was still in the low 40 percent range around 2007, but skyrocketed to 70 percent by 2021. In one fell swoop, the U.S. Supreme Court struck down all state laws criminalizing homosexual conduct in the Lawrence v. Texas decision in 2003, and in 2004, Massachusetts became the first state to legalize same-sex marriage. By 2012, President Obama, in a reversal of his earlier professed views, was endorsing same-sex marriage, and just one year later, the Supreme Court was again getting in on the act, making it unconstitutional to deny federal benefits to same-sex spouses.

Empirical work that accounts for a cultural lag, viz., a period of delay between a cultural landmark and a resulting widespread social change, makes clear the correlation between the legalization of same-sex marriage and declining fertility rates. The dire consequences of those declining fertility rates include an older population and a smaller workforce, resulting in lower growth and economic productivity, even while there are fewer working-age people available to be taxed in order to support the social security system on which an aging population is dependent. If we continue along our present path, in short, we will find ourselves living in an America afflicted by the same population collapsethat has devastated much of Europe and made it reliant on culturally destabilizing mass immigration (from the more socially conservative, and thus more demographically healthy, third world) to sustain its fading economies.

But beyond even the level of these purely practical considerations, we should consider the cultural significance of a society deviating ever further from traditional family structure and traditional sexuality. The reason alternative lifestyles are proliferating among us, after all, is not merely on account of our greater tolerance for such choices. That explosive push for greater tolerance in recent decades was itself kindled by the long-simmering flame of 1960s counterculture increasingly institutionalized and ensconced in positions of power. Rebelling against the conformity of a post-World-War II nation lorded over by strait-laced military heroes and veterans, the baby boomer generations counterculture unleashed a ferocious assault on such conformity, championing rebels, drop-outs and deviants. Free expression and non-traditional lifestyles were core components of this go-your-own-way generations message.

What occurred as a predictable result is the undermining of all erstwhile sources of stability and meaning, whether organized religion, local community life or the institution of the family and the sexual practices associated with it. Just as organized religion gave way to a desperate hankering after alternative modes of spirituality through which individuals sought a more intimate, personal connection with the divine, traditional heterosexual relationsassociated with procreation, family life, and suddenly restrictive patriarchal normsbegan to give way to a desperate hankering after alternative modes of sexual expression through which individuals sought a more intimate, personal connection with themselves and one another. Anticipating these developments in his 1955 work, Eros and Civilization, the Frankfurt School alum and Father of the New Left Herbert Marcuse encapsulated this sense that sexual deviancy, with its defiance of paternalistic sexual norms, was a pursuit of some species of greater pleasure than that available through the thing that everyone did:

The perversions seem to give a promesse de bonheur [i.e., promise of happiness or gratification] greater than that of normal sexuality. What is the source of their promise? Freud emphasized the exclusive character of the deviations from normality, their rejection of the procreative sex act. The perversions thus express rebellion against the subjugation of sexuality under the order of procreation, and against the institutions which guarantee this order. Psychoanalytic theory sees in the practices that exclude or prevent procreation an opposition against continuing the chain of reproduction and thereby of paternal dominationan attempt to prevent the reappearance of the father. The perversions seem to reject the entire enslavement of the pleasure ego by the reality ego. Claiming instinctual freedom in a world of repression, they are often characterized by a strong rejection of that feeling of guilt which accompanies sexual repressionIn a repressive order, which enforces the equation between normal, socially useful, and good, the manifestations of pleasure for its own sake must appear as fleurs du mal [i.e., flowers of evil]. Against a society which employs sexuality as means for a useful end, the perversions uphold sexuality as an end in itselfThey establish libidinal relationships which society must ostracize because they threaten to reverse the process of civilization which turned the organism into an instrument of work.

Here is the catch: As the Berkeley sociologist Robert Nisbet argued in far greater detail in Community and Power (1962), the detachment of more and more individuals from traditional communal institutions and practices creates a vicious circle. Their more intrinsic rewards aside, organized religion and the traditional family confer the most meaning and personal satisfaction upon individuals when such institutions are widely esteemed and directly connected to external hallmarks of value, whether exclusive economic benefits or cherished social standing. When more and more of us jump ship while economic and social value and esteem are shifted elsewhere, what remains behind will no longer seem as appealing. The old forms will lose their haloes, the sense of an enchanted life in which they could once envelop us. But because the new modes of expression arising in place of the old are explicitly posed as antinomian, counter-hegemonic, and individualized, they, of necessity, cannot succeed in effectuating a complete transfer to themselves of that elusive sense of wholeness and enchantment associated with their predecessors. What they inevitably bring about, instead, is a version of the hedonic treadmill, as the next fleeting spiritual and sexual trend succeeds the last in ever-more rapid succession, with proponents of each successive iteration repeatedly finding themselves looking in the rearview mirror at speeding bandwagons overtaking the ones they had only recently mounted. And this, of course, is precisely what we have seen arise among us, as the icons of one sexual revolution, such as Martina Navratilova, become the demonized rearguard impeding the progress of the next wave. The unsurprising end result is an all around loss of collective and individual meaning and life satisfaction, as society degenerates from a crucible refining a diverse citizenry into a sturdy universal alloy to a spinning centrifuge unceremoniously hurling more and more of us outward toward irreconcilable opposite poles.

To be sure, the lost soul hankering after ever-better alternatives or desperately switching from one gender to another and back in search of that elusive sense of calm in the storm is a victim caught in our social maelstrom and need not be blamed, scolded, or stigmatized for our collective failings. The solution to this problem is communal, not individual. It is about what we teach and dont teach our children at school, what we show and dont show them on screens, what our laws prohibit and permit, what our institutions incentivize and disincentivize, what our psychological, psychiatric, and medical associations adopt and reject as their governing norms and ideologies. Making the lives of gay or transgender people more difficult than they may already be is a far less appealing option than making gay or transgender lifestyles less appealing in the first place. There are those, as I have said, who will be gay in any society. They have always existed. Let them be. It is the far larger number of toss-up cases with whom we are concerned. Instead of punishing adults after the fact, let us work to avoid tempting kids to make the errors in judgment that lead them into the wilderness.

And let us, most of all, endeavor with all our collective imagination and resolve to re-mythologize and re-enchant our traditions and traditional sexual experiences that the counterculture has done its utmost to uproot. We do this by changing laws and norms, yes, but we do it, first and foremost, by singing hymns, erecting images, and telling stories, both real and fictional, both sacred and secular. A few well-rendered tales of great doomed loveRomeo and Juliet, Anthony and Cleopatra, Troilus and Cressidawill save more souls than a thousand legislative enactments ever could. We must preach this gospel vigorously and persistently not only for the sake of our own congregation but for the sake, still more, of those who have strayed and who do not realize that what they were seeking was waiting for them right here at home all along.

Alexander Zubatovis a practicing attorney specializing in general commercial litigation. He is also a practicing writer specializing in general non-commercial poetry, fiction, essays, and polemics that have been featured in a widevariety of publications. He lives in the belly of the beast in New York, New York. He can be found on Twitter@Zoobahtov.

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The LGBTsQewing of America - The American Conservative

There are estimated to be less than 150 Malayan Tigers left in the wild.

JACKSONVILLE, Fla. A critically endangered male Malayan Tiger is now calling the Jacksonville Zoo and Gardens his new home.

The zoo announced the addition of Bashir, a 13-year-old, male critically endangered Malayan Tiger in a press release Tuesday.

The zoo says he actually arrived in early April and has been adjusting well to his new home.

Bashir is acclimating nicely and at his own pace, said Tirzah Nichols, Senior Mammal Keeper. We pay close attention to his comfort levels in his new surroundings, monitor his progress and only introduce him to new areas when he is ready.

The keeper staff at the Zoo say they have been spending time developing a positive relationship with Bashir and establishing trust while he settles into his new home.

According to the staff, Bashir is relaxed, but very charismatic, vocal and expressive. He enjoys his toys and exploring new environments.

Bashir joined the Zoo through the Species Survival Plan (SSP) between accredited zoos and aquariums. SSP looks at the genetics of captive populations to make the best pairings to ensure these endangered species thrive.

Bashir is recommended to breed with the zoo's current Malayan female, Cinta.

There are estimated to be less than 150 Malayan Tigers left in the wild.

Jacksonville Zoo and Gardens is excited to participate in such significant conversation efforts, said Nichols. With a critically endangered status, species like the Malayan Tiger can significantly benefit from our joined efforts with other institutions to help ensure their future survival.

Bashir made his debut on May 5, in the award-winning Land of the Tiger exhibit.

Jacksonville Zoo and Gardens is open daily.

Visit jacksonvillezoo.org for admission tickets.

Continued here:
Endangered Malayan Tiger comes to the Jacksonville Zoo and Gardens - FirstCoastNews.com WTLV-WJXX

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For close to a hundred years, it has been one of natures greatest whodunnits involving egg forgeries and plenty of deception.

It is all part of an evolving arms race taking place out on the grasslands of Africa between a nondescript brood parasite and the host species it preys on.

The parasite is a small sparrow-sized bird called a cuckoo finch whose reproductive cycle involves sneaking into the nests of other birds and laying its eggs.

For the cuckoo finch to be successful, the egg needs to be almost identical to its host. If the forgery is spotted in time, the host species will spear the egg with its beak, remove it from its nest and drop it in the grass.

It is the cuckoo finchs success that is the mystery.

Zweli Mkhizes race against time and the Special Investigating Unit

Generations of female cuckoo finches have evolved the ability to broadly mimic the egg appearance of several different host species, each of which lays a distinct range of egg types. How cuckoo finches and other brood parasitic bird species are able to evolve such specialised adaptations to different host species, despite interbreeding between males and females raised by different hosts, has been a long-standing mystery.

This has puzzled scientists because the usual mix of genetics inherited by both parents should cause the colours of these eggs to vary from mother to daughter, depending on who the father was.

Now genetic research by an international team of scientists led by Prof Claire Spottiswoode from the University of Cape Towns Percy FitzPatrick Institute of African Ornithology and the University of Cambridges Department of Zoology believe they have cracked the mystery and what they have found is mixed news to those avian egg forgers.

Cuckoo finches are rather enigmatic birds, and many birdwatchers have never seen one, says Spottiswoode, who has been studying the birds in southern Zambia, together with colleagues from the local community.

The cuckoo finch is found across sub-Saharan Africa, favouring grasslands particularly close to water sources. And even though the bird is widespread, ornithologists arent even sure how many host species the cuckoo finch has.

There could be as many as 10 host species, but the female cuckoo finch will only target one of these in her lifetime.

For the female cuckoo finch to sneak her egg into a nest requires excellent timing and a keen eye. She first needs to spot the nest of the parents that are going to rear her chick.

They have a small window of opportunity; they need to get their own egg in during the laying period of the host, explains Spottiswoode.

She and her colleagues found that the secret to the cuckoo finchs ability to produce eggs that fool their hosts has to do with the W chromosome that is passed from mother to daughter. The W chromosome is similar to the male-specific Y chromosome in humans, in that it is carried by one sex only. Except in birds, it is carried only in females rather than in males.

So, that means theres a chunk of DNA that is passed down from mother to daughter, largely unaffected by gene flow from the father. So crucially, this could allow different lineages of females to evolve specialised adaptations that can be carried on, or is regulated by that chromosome that can be passed on to their daughters regardless of who the daughters father was, explains Spottiswoode.

Our data from the cuckoo finch in Zambia exactly matches that long-standing idea, because we see that females laying different egg types belong to distinct maternal lineages that diverged from each other hundreds of thousands to millions of years ago. Yet they all remain part of the same species, because maternal inheritance means that these specialised females can mate randomly with any cuckoo finch male, regardless of what host species he was raised by, and still pass on their specialised adaptations to their daughters.

Their findings were published in a recent issue of the academic journal Proceedings of the National Academy of Sciences.

The discovery validates an idea geneticist Reginald Punnett first suggested in 1933. He had hypothesised that European common cuckoos inherited their egg mimicry abilities from their mothers.

Their research involved collecting DNA samples from 196 cuckoo finches from 141 nests at their field site in southern Zambia.

The cuckoo finches were located in the nests belonging to four different grass warbler species. Here, the researchers saw ongoing one-upmanship between host and parasite.

To counteract the cuckoo finches, the grass warblers have become skilled quality controllers. They are quick to reject eggs that differ from their own and they have a secret weapon each female has a unique signature she leaves on her eggs. Its a kind of biological watermark that helps her detect intruder eggs.

Cuckoo finches, in turn, have evolved mimicry of some but not all of these host egg signatures.

An example of this has been shown in previous studies in one of the cuckoo finchs hosts, the tawny-flanked prinia, that produces a diversity of egg colours. Cuckoo finches lay eggs mimicking red, blue and white prinia eggs, but not the rich olive green eggs laid by some prinia females.

The new work suggests a likely hypothesis for why cuckoo finches are sometimes unable to mimic all the signature types that hosts can produce: maternal inheritance slows down evolution by forgoing the diversity produced by genetic mixing between males and males.

This likely explains why cuckoo finches cant forge certain egg types produced by their hosts, which the study shows inherit their egg appearance from both parents.

So while maternal inheritance gives parasites an important advantage in allowing them to evolve distinct mimicry of multiple distinct hosts, this could also have a downside in slowing down their ability to evolve to keep up in evolutionary arms races with their hosts.

This arms race between host and brood parasite isnt just about finding ways of passing and spotting egg forgeries. Hosts have evolved other methods to stop brood parasites from laying their eggs in their nests. Some species of weavers, for instance, have lengthened the entrances to their nests, making it harder for cuckoos to enter.

I have seen on three occasions where weavers have trapped cuckoos trying to get into their nest. With those entrance tunnels they sometimes get stuck.

And when this happens, the whole community of weavers will rush in and effectively weave the cuckoo into the nest. They seal her in, says ornithologist Geoff Lockwood, who wasnt involved in the cuckoo finch study.

Brood parasites are fighting back too, by using new methods of deception.

What we think might be happening with some of the honey guides, is that the male hangs around causing trouble, showing himself and driving the host species frantic. They then go and chase it away, and while the chase is on, the female sneaks in, drops an egg and takes one of the hosts eggs away, explains Lockwood.

But this is a war the brood parasite cant win outright.

If they are too successful, then the host population is depleted to the point where its almost impossible to find a nest then the cuckoo or brood parasite will also go into massive decline, says Lockwood. DM/OBP

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EGGCELLENT FORGERY: Scientists crack the mystery of how the cuckoo finch gets other birds to raise its brood - Daily Maverick

Adrion JR, White PS, Montooth KL (2016) The roles of compensatory evolution and constraint in aminoacyl tRNA synthetase evolution. Mol Biol Evol 33:152161

CAS PubMed Article Google Scholar

Allio R, Donega S, Galtier N, Nabholz B (2017) Large variation in the ratio of mitochondrial to nuclear mutation rate across animals: implications for genetic diversity and the use of mitochondrial DNA as a molecular marker. Mol Biol Evol 34:27622772

CAS PubMed Article Google Scholar

Allison TM, Radzvilavicius AL, Dowling DK (2021) Selection for biparental inheritance of mitochondria under hybridization and mitonuclear fitness interactions. Proc Biol Sci 288:20211600

CAS PubMed PubMed Central Google Scholar

Arrieta-Montiel MP, Mackenzie SA (2011) Plant mitochondrial genomes and recombination. In: Kempken F (ed.) Plant Mitochondria. Springer New York, New York, NY, p 6582

Chapter Google Scholar

Ashar FN, Zhang Y, Longchamps RJ, Lane J, Moes A, Grove ML et al. (2017) Association of mitochondrial DNA copy number with cardiovascular disease. JAMA Cardiol 2:12471255

PubMed PubMed Central Article Google Scholar

Baldo L, Bordenstein S, Wernegreen JJ, Werren JH(2006) Widespread recombination throughout Wolbachia genomes Mol Biol Evol 23:437449

CAS PubMed Article Google Scholar

Barbrook AC, Voolstra CR, Howe CJ (2014) The chloroplast genome of a Symbiodinium sp. clade C3 isolate. Protist 165:113

CAS PubMed Article Google Scholar

Barr CM, Neiman M, Taylor DR (2005) Inheritance and recombination of mitochondrial genomes in plants, fungi and animals. N. Phytol 168:3950

CAS Article Google Scholar

Barreto FS, Watson ET, Lima TG, Willett CS, Edmands S, Li W et al(2018) Genomic signatures of mitonuclear coevolution across populations of Tigriopus californicus Nat Ecol Evolution 2:12501257

Article Google Scholar

Baur E (1908) Das Wesen und die Erblichkeitsverhltnisse der Varietates albomarginatae hort. vonPelargonium zonale. Z fr Indukt Abstamm- und Vererbungslehre 1:330351

Google Scholar

Beck EA, Thompson AC, Sharbrough J, Brud E, Llopart A (2015) Gene flow between Drosophila yakuba and Drosophila santomea in subunit V of cytochrome c oxidase: A potential case of cytonuclear cointrogression. Evolution 69:19731986

CAS PubMed PubMed Central Article Google Scholar

Bennett GM, Moran NA (2013) Small, smaller, smallest: the origins and evolution of ancient dual symbioses in a Phloem-feeding insect. Genome Biol Evol 5:16751688

PubMed PubMed Central Article CAS Google Scholar

Bensasson D, Zhang D-X, Hartl DL, Hewitt GM (2001) Mitochondrial pseudogenes: evolutions misplaced witnesses. Trends Ecol Evol 16:314321

CAS PubMed Article Google Scholar

Bentley KE, Mandel JR, McCauley DE (2010) Paternal leakage and heteroplasmy of mitochondrial genomes in Silene vulgaris: evidence from experimental crosses. Genetics 185:961968

Birky Jr CW (2001) The inheritance of genes in mitochondria and chloroplasts: laws, mechanisms, and models. Annu Rev Genet 35:125148

CAS PubMed Article Google Scholar

Birky CW, Strausberg RL, Forster JL, Perlman PS (1978) Vegetative segregation of mitochondria in yeast: Estimating parameters using a random model. Mol Gen Genet 158:251261

Article Google Scholar

Blokhin A, Vyshkina T, Komoly S, Kalman B (2008) Variations in mitochondrial DNA copy numbers in MS brains. J Mol Neurosci 35:283287

CAS PubMed Article Google Scholar

Bock DG, Andrew RL, Rieseberg LH (2014) On the adaptive value of cytoplasmic genomes in plants. Mol Ecol 23:48994911

PubMed Article Google Scholar

Boore JL (1999) Animal mitochondrial genomes. Nucleic Acids Res 27:17671780

CAS PubMed PubMed Central Article Google Scholar

Bordenstein SR, OHara FP, Werren JH(2001) Wolbachia-induced incompatibility precedes other hybrid incompatibilities in Nasonia Nature 409:707710

CAS PubMed Article Google Scholar

Boulet L, Karpati G, Shoubridge EA (1992) Distribution and threshold expression of the tRNA(Lys) mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF). Am J Hum Genet 51:11871200

CAS PubMed PubMed Central Google Scholar

Boyd BM, Chevignon G, Patel V, Oliver KM, Strand MR (2021) Evolutionary genomics of APSE: a tailed phage that lysogenically converts the bacterium Hamiltonella defensa into a heritable protective symbiont of aphids. Virol J 18:219

Breton S, Beaupr HD, Stewart DT, Hoeh WR, Blier PU (2007) The unusual system of doubly uniparental inheritance of mtDNA: isnt one enough? Trends Genet 23:465474

CAS PubMed Article Google Scholar

Breton S, Burger G, Stewart DT, Blier PU (2006) Comparative analysis of gender-associated complete mitochondrial genomes in marine mussels (Mytilus spp.). Genetics 172:11071119

CAS PubMed PubMed Central Article Google Scholar

Brown TA, Cecconi C, Tkachuk AN, Bustamante C, Clayton DA (2005) Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism. Genes Dev 19:24662476

CAS PubMed PubMed Central Article Google Scholar

Brown WM, George Jr M, Wilson AC (1979) Rapid evolution of animal mitochondrial DNA. Proc Natl Acad Sci USA 76:19671971

CAS PubMed PubMed Central Article Google Scholar

Broz AK, Waneka G, Wu Z, Fernandes Gyorfy M, Sloan DB (2021) Detecting de novo mitochondrial mutations in angiosperms with highly divergent evolutionary rates. Genetics 218:iyab039

Burton RS (1990) Hybrid breakdown in developmental time in the copepod Tigriopus californicus. Evolution 44:18141822

Burton RS, Lee BN(1994) Nuclear and mitochondrial gene genealogies and allozyme polymorphism across a major phylogeographic break in the copepod Tigriopus californicus Proc Natl Acad Sci USA 91:51975201

CAS PubMed PubMed Central Article Google Scholar

Burzyski A, Zbawicka M, Skibinski DOF, Wenne R(2003) Evidence for recombination of mtDNA in the marine mussel Mytilus trossulus from the Baltic. Mol Biol Evol 20:388392

PubMed Article Google Scholar

Camus MF, Wolff JN, Sgr CM, Dowling DK(2017) Experimental support that natural selection has shaped the latitudinal distribution of mitochondrial haplotypes in Australian Drosophila melanogaster Mol Biol Evol 34:26002612

CAS PubMed Article Google Scholar

Carelli V, Maresca A, Caporali L, Trifunov S, Zanna C, Rugolo M (2015) Mitochondria: Biogenesis and mitophagy balance in segregation and clonal expansion of mitochondrial DNA mutations. Int J Biochem Cell Biol 63:2124

CAS PubMed Article Google Scholar

Carnegie L, Reuter M, Fowler K, Lane N, Camus MF(2021) Mothers curse is pervasive across a large mitonuclear Drosophila panel Evol Lett 5:230239

PubMed PubMed Central Article Google Scholar

Carrier TJ, Leigh BA, Deaker DJ, Devens HR, Wray GA, Bordenstein SR et al. (2021) Microbiome reduction and endosymbiont gain from a switch in sea urchin life history. Proc Natl Acad Sci USA 118:e2022023118

Cato SA, Richardson TE (1996) Inter- and intraspecific polymorphism at chloroplast SSR loci and the inheritance of plastids in Pinus radiata D. Don. Theor Appl Genet 93:587592

Cerutti H, Johnson AM, Boynton JE, Gillham NW(1995) Inhibition of chloroplast DNA recombination and repair by dominant negative mutants of Escherichia coli RecA Mol Cell Biol 15:30033011

CAS PubMed PubMed Central Article Google Scholar

Charlat S, Hornett EA, Fullard JH, Davies N, Roderick GK, Wedell N et al. (2007) Extraordinary flux in sex ratio. Science 317:214

CAS PubMed Article Google Scholar

Charlat S, Reuter M, Dyson EA, Hornett EA, Duplouy A, Davies N et al. (2007) Male-killing bacteria trigger a cycle of increasing male fatigue and female promiscuity. Curr Biol 17:273277

CAS PubMed Article Google Scholar

Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J Biol Chem 267:166172

CAS PubMed Article Google Scholar

Chevigny N, Schatz-Daas D, Lotfi F, Gualberto JM (2020) DNA repair and the stability of the plant mitochondrial genome. Int J Mol Sci 21:328

Chiu W-L, Stubbe W, Sears BB(1988) Plastid inheritance in Oenothera: organelle genome modifies the extent of biparental plastid transmission Curr Genet 13:181189

CAS Article Google Scholar

Christie JR, Beekman M (2017) Selective sweeps of mitochondrial DNA can drive the evolution of uniparental inheritance. Evolution 71:20902099

CAS PubMed Article Google Scholar

Christie JR, Schaerf TM, Beekman M (2015) Selection against heteroplasmy explains the evolution of uniparental inheritance of mitochondria. PLoS Genet 11:e1005112

PubMed PubMed Central Article CAS Google Scholar

Ciborowski KL, Consuegra S, Garca de Leniz C, Beaumont MA, Wang J, Jordan WC (2007) Rare and fleeting: an example of interspecific recombination in animal mitochondrial DNA. Biol Lett 3:554557

CAS PubMed PubMed Central Article Google Scholar

Clark KA, Howe DK, Gafner K, Kusuma D, Ping S, Estes S et al(2012) Selfish little circles: transmission bias and evolution of large deletion-bearing mitochondrial DNA in Caenorhabditis briggsae nematodes PLoS One 7:e41433

CAS PubMed PubMed Central Article Google Scholar

Clay Montier LL, Deng JJ, Bai Y (2009) Number matters: control of mammalian mitochondrial DNA copy number. J Genet Genomics 36:125131

PubMed PubMed Central Article CAS Google Scholar

Cleland RE (1963) The cytogenetics of Oenothera. Adv Genet 11:147237

Cole LW, Guo W, Mower JP, Palmer JD (2018) High and variable rates of repeat-mediated mitochondrial genome rearrangement in a genus of plants. Mol Biol Evol 35:27732785

CAS PubMed Google Scholar

Correns C (1909) Zur kenntnis der rolle von kern und plasma bei der vererbung. Z Indukt Abstamm Vererbungsl 2:331340

Google Scholar

Dahal S, Dubey S, Raghavan SC (2018) Homologous recombination-mediated repair of DNA double-strand breaks operates in mammalian mitochondria. Cell Mol Life Sci 75:16411655

CAS PubMed Article Google Scholar

Dai B, Guo H, Huang C, Zhang X, Lin Z (2016) Genomic heterozygosity and hybrid breakdown in cotton (Gossypium): different traits, different effects. BMC Genet 17:58

Davila JI, Arrieta-Montiel MP, Wamboldt Y, Cao J, Hagmann J, Shedge V et al. (2011) Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis. BMC Biol 9:64

Day A, Madesis P (2007) DNA replication, recombination, and repair in plastids. In: Bock R (ed) Cell and Molecular Biology of Plastids. Springer Berlin Heidelberg, Berlin, Heidelberg, p 65119

Chapter Google Scholar

De Vooght L, Caljon G, Van Hees J, Van Den Abbeele J (2015) Paternal transmission of a secondary symbiont during mating in the viviparous tsetse fly. Mol Biol Evol 32:19771980

PubMed PubMed Central Article CAS Google Scholar

DeBalsi KL, Hoff KE, Copeland WC (2017) Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases. Ageing Res Rev 33:89104

CAS PubMed Article Google Scholar

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It could be in their genes, posits Tangye. Genetic influences are either making people vulnerable to really severe disease but may also contribute to resistance there are populations of people who probably should have been infected and sick but werent.

Exactly which genes have a protective effect is part of an international research project called the COVID Human Genetic Effort, that Christodoulou is involved with.

We are collecting information and DNA from individuals who have been hyperexposed to COVID but who dont seem to contract COVID for example, living in a household where multiple family members were infected, but one member of the household wasnt to see if genetic factors can be identified that might offer protection against COVID infection, says Christodoulou, who is also the chair of Genomic Medicine at the University of Melbourne.

While researchers keep searching for the genetic clues, a new study published at the end of April, found booster shots can increase the range of immune cells, called memory B cells, making them more effective at neutralising COVID.

With any infection or vaccination, our body responds and then forgets the virus, explains Tangye, but becomes better at responding with repeated exposure. The first and second doses are like the training, getting your immune system into good shape and ready to take off and the third really gives you the protection you are primed and ready to go.

So if someone who has recently been vaccinated is exposed to COVID, they may be protected. If they have been boosted, this may provide even more protection, at least for a time.

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The degree of exposure how long we were in contact with someone and whether we were inside or out will also make a difference, as will our behaviour.

People have become much more cognisant of social distancing and washing their hands and wearing masks. There are those non-pharmaceutical interventions people have embraced, Tangye says.

As for how healthy you are generally, that unfortunately wont make us resistant to catching COVID.

We regularly hear of otherwise young, fit and healthy individuals contracting very severe COVID, says Christodoulou. For those otherwise healthy people we know that there are some factors that are associated with this, e.g., having so-called auto-antibodies to type 1 interferons (type 1 interferons are the first line of defence against COVID) or having mutations in genes that are involved in production and function of type 1 interferons.

Being healthy is good. But healthy people are still getting sick. Its not a panacea.

Interestingly, Tangye adds that there are people who naturally have this type 1 interferon pathway turned up a little bit: That can be pathogenic they can get these inflammatory diseases that dont have a defined triggerthese non-infectious, spontaneous flares for no good reason but people with those conditions may well have some resistance to COVID just because they have that innate immune response primed.

These people account for only a fraction of never COVIDs. For the rest, it seems to come down to a combination of immunity, genetics, environment and luck.

Being healthy all round puts you in better shape against infectious diseases and lifestyle disease, says Tangye. Being healthy is good. But healthy people are still getting sick. Its not a panacea.

Most of us may not be able to do much to avoid the virus, but we can still look to never COVIDs for some answers.

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If we can identify genetic reasons why people dont get COVID, it may help inform ways by which SARS COV2 enters or attacks our cells remember viruses are hopeless on their own. They need all the machinery of our cells to be disease-causing, explains Tangye.

So if we can disrupt the human cell processes without too many adverse events we could be better at stopping viral infection.

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As medical and recreational cannabis becomes more widespread, the industry is becoming more professional. Those wishing to become cannabis farmers have to adhere to the rigors of the industry, producing safe, consistent, and high-quality products. The path to a successful business isnt smooth or easy. Because its a living plant, you should grow the herb as nature intended. Keeping that in mind, seeds are paramount for every cannabis grower. You wont have any kind of trouble finding an assortment of high-quality cannabis seeds to choose from. These days, companies cater to all customers.

The use of high-quality seeds is vitally important for growing healthy cannabis plants. Of course, the final result depends on a multitude of factors, including adequate watering, nutrient availability, and good light quality, but it all begins with superior genetics. If youve never shopped around for cannabis seeds, the chances are that youre at a loss. The remarkable variety is enough to make you feel confused. Its essential to be wise when buying cannabis seeds, as not all online cannabis seed banks are created equal. These considerations will help you make a decision.

Strains represent different breeds of cannabis. Each individual strain is bred for its specific characteristics by a cannabis cultivator. Cannabis is split into three species, namely:

There are countless strains of cannabis, most of which are strains of one of the three subspecies. Hybrid strains are a combination of sativa and indica genetics. Indicas are recommended for new cannabis growers because theyre more adaptable to long-term cultivation owing to their size-to-flower ratio. Cannabis indica plants have broad leaves and thrive in environments with slightly cooler temperatures. They tend to be high in THC content.

Cannabis sativa plants, on the other hand, grow to heights of twenty feet, so theyre typically grown outdoors. Sativa-dominant strains can be grown indoors, but its a little bit more complicated. The payoff is worth the effort, so have some patience. Once the plants begin to flower, it can take up to ten or twelve weeks to be ready to harvest. Cannabis sativa is used in medicines, body care products, food, nutritional supplements, and even building materials.

Last but not least, cannabis Ruderalis plants are very durable, meaning that they can survive in the harshest weather conditions. They dont depend on light exposure for the flowering process, unlike the plants discussed earlier. The seeds go into the flowering mode automatically, which is complete after ninety to one hundred and ten days. Ruderalis is naturally high in CBD. Ruderalis genes enable breeders to create autoflowering hybrid strains.

When growing cannabis plants, the type of seeds matters as well. In the cannabis seed market, you can purchase both regular and feminized cannabis seeds. Tempting as it may be to choose regular cannabis seeds because of the cheap price tag, there are a couple of things to reflect upon. The seeds give rise to 50% male and 50% female offspring. The disadvantage is that you have to immediately identify the males and throw them out. If you dont, theyll pollinate the females. Just so you know, theres a high chance of getting more male plants in your cannabis plantation.

If practicality and simplicity are what youre looking for, feminized seeds are a better choice. Feminized cannabis seeds are genetically engineered to become female plants, which produce resin-rich buds. Youll have peace of mind knowing that all your plants will turn out to be female. If you grow the cannabis plants indoors, you can take control of the growing stages with a grow light timer. Youll easily be able to switch from the vegetative phase to the flowering phase. Keep in mind that cannabis plants are photoperiodic.

More and more cannabis growers seem to show interest in autoflowering seeds. They start to bloom on their own after only four weeks. The seeds are feminized, so they wont produce males. The height of the autoflowering plants ranges between one and three feet. The seeds can be, therefore, planted indoors, on the balcony. Most importantly, the plants are resilient, which is fantastic for beginner growers. You can obtain multiple harvests pers season. As youll discover, autoflowering plants are resistant to many diseases, so youll experience less trouble.

Seeds usually contain nominal THC levels that dont exceed the 0,3% maximum level imposed by the European Council, yet theres no way of knowing if the resulting plants THC level will fall below the limits. Whether for medical or recreational purposes, the concentration of THC is of prime importance. The THC content of cannabis offered in medical programs tends to be higher than 5-and 10%. Its enough to reduce chronic pain with minimal side effects. Cannabis contains many active compounds, and CBD is the most promising one from a medical perspective..

According to Seedsman, each plant from the cannabis seeds has a unique taste and smell. Not that long ago, there were only three types of flavors: fruity, floral, and earthy. Now, there are countless flavors and aromas, such as the aroma of cheese, the woody taste, or the smell of jasmine. Sensory judgements become necessary to consumers.

Cannabis comprises more than 120 compounds, referred to as cannabinoids. Cannabis may be of benefit in the treatment of chronic pain, depression, PTSD, social anxiety, and epilepsy, to name a few. The type of cannabis seed makes all the difference, so choose accordingly. Take into account the effects of the strain and figure out if it produces desirable results when it ends up in the hands of consumers.

Finally, yet importantly, avoid using seeds from a bag. The best thing you can do is to reach out to a reputable seed bank like Seedsman. They have a variety of cannabis seeds for you to consider. The germination promise that you get from the brand is good enough to give you the assurance youre buying the best cannabis seeds. The seeds are delivered to you safely and discreetly. Seedsman, in particular, stocks specialized strains from licensed breeders. Some of the most popular strains include Skunk, Sour Diesel, and White Widow. Its worth mentioning that every order includes free seeds.

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How To Choose The Right Type Of Seeds To Grow - News Anyway

Throughout evolution, humans have looked for traits that would grant them a better chance at survival and reproduction. Larger women signified health, the ability to bear children, money, and food therefore, a better chance at survival and continuing on your lineage.

The traits that evolution deemed desirable still linger for us subconsciously, but act alongside many other factors, such as the mass influence of cultural standards of beauty.

In various cultures, whatever is in vogue, people have tried to manipulate their bodies to look that way, Cristen Harris, associate teaching professor of epidemiology, said. Whether it be the tiny waist, so the Victorian era, or even back in the 40s and 50s. In this country, in the middle of [the] Marilyn Monroe days, there were ads for dietary supplements for weight gainers for women to be voluptuous.

As time has gone on and moved past the cultural phase of idealizing bodies like Marilyn Monroes, we have seen an increase in idealizing a body type that, for most women, is unattainable.

The general public and media tell us that we should (ideally) have all of the following: big boobs and a big butt (but not too big that it looks fake; it has to look natural), flat stomach, toned (but not muscular cause thats too masculine), petite and short frame, no hair (except for on your head), and skinny but not too skinny (dont wanna look sickly).

It should be noted that although Im focusing on young women's struggles, cultural standards of beauty affect people of all ages, races, and genders.

We do see evidence that 3-to-5-year-olds express concern about not getting too fat, Harris said. Then we see that persist throughout adolescence, throughout college years or young adulthood, [and] we're seeing eating disorders and body image concerns continue through to older age, people in their 70s and older that are still concerned about dieting, to lose weight to fit into that mold.

Young women, especially college-age women, are under a microscope to fit within this mold, with the popular notion that we are in our prime or peak as far as looks go.

According to a 2021 study by The Emily Program, any college student, whether male, female, or nonbinary, has an increased risk of developing some kind of eating disorder. However, women and gender minorities are almost four times more likely to show symptoms of an eating disorder than cisgender men.

On top of this, college women are going through the phase of their lives where they are under the most pressure to appeal to the male gaze.

Hookup culture at any college is without shame and very obvious. There are many opportunities on a weekly basis for people to hook up, and if you are not actively doing this, it can be hard not to question if there is something you need to change about yourself.

There is a concept in the Greek system called gads (grab-a-date), where you can only get invited to a party if a boy asks you. As much as we all want to not be seen as pick me girls, its almost impossible not to question yourself when youre not picked.

Some might say, as a solution to these insecurities, If you arent happy with the way you look or your body, just fix it by working out and dieting.

This fix it mentality simplifies an extremely complicated issue. It is incredibly harmful and not realistic whatsoever. For some people, health-wise, nothing needs to be fixed.

I think part of the issue is that people seem to draw a straight line between body size and health, Harris said. There are numerous factors that determine whether a person is healthy or not, and how do we really even define that? Is it the absence of disease? What about a person who has had cancer and they're in remission?

The health benefits, both physically and mentally, of moving your body should not be ignored. However, given the health repercussions of neglecting your body, our understanding of health has become incredibly skewed.

Research shows that about a third of people who are in a normal body size according to BMI are metabolically unhealthy, and about a third of people who are in overweight or obese body size according to BMI are metabolically healthy, Harris said.

All bodies metabolize differently. While one inactive woman could eat, let's say, five full meals per day and stay at 115 pounds, another woman could be working out constantly, consistently gaining weight, and only eating one or two meals a day because of factors such as stress, genetics, or medications.

Many people are not aware of the negative effects of dieting, and how the very act of relentlessly trying to fit into the desired mold of beauty and health actually makes you more unhealthy.

Studies show that the consequences of eating disorders and disordered eating are incredibly consequential to a woman's long-term health reproductive, physical, and mental.

The other thing about body positivity is it kind of puts the onus on the person to do their own inner work, to try to cultivate some kind of love for their body, Harris said. Really, the onus is on culture and society to get with the program, let everybody be who they are.

Speaking from personal experience as a sorority member at UW, I have found this to be the hardest environment to be in with regard to keeping a positive body image.

While I have experienced the body image issues that every other human has, I have the privilege of never having seriously struggled with an eating disorder. Still, I have found it incredibly hard not to neglect my body.

I can feel the panic that goes through some of my closest girlfriends when they walk into our kitchen and are faced with the daunting task of choosing and eating a meal.

We still need to do a much better job as college women. It is long overdue that we give ourselves, and each other, a break when it comes to our bodies that do so much for us.

Reach writer Mary Murphy at opinion@dailyuw.com. Twitter: @marymurphy301

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Marijuana has never been more popular throughout the United States. According to several studies and research centers, an overwhelming number of Americans support legalization. With more and more states decriminalizing marijuana use, hemp production and the growth of the cannabis seeds industry are also on the rise.

As a result of this demand, the internet is now stacked with cannabis seed banks that ship globally. You will find thousands of these online seed banks with a quick Google search. They provide home growers with the seeds needed to grow cannabis strains, making many people consider growing their cannabis plants at home.

With this new and largely unregulated industry, vendors have a wide range in quality. For example, some may provide you with high-quality seeds, while others may distribute marijuana seeds that did not successfully germinate. However, not all of them are reputable seed banks.

To help you find trustworthy, high-quality marijuana seeds, we have compiled a list of the best online seed banks. Youll be able to easily order the cannabis seeds and start producing them in no time!

I Love Growing Marijuana sells premium marijuana seeds of so many different types. Whether you are a pro who has been at this for a while, or someone looking to try this for the first time, there are seeds with your name on them!

The site is also a great learning tool. If you dont know a lot about growing marijuana, this site is full of resources to get you started. Once you got a handle on the growing process, you can experiment with other types of strains until you are growing plants perfect for your needs.

Sometimes you dont know what kind of seeds you want, but you know what you need them to treat. Sometimes you dont know what kind of seeds you want, but you know what kind of climate you have for growing them. Thats where MSNL comes into play.

MSNL is a great site for buying seeds to treat a specific illness. For example, if you are suffering from post-traumatic stress disorder, you can buy seeds that are proven to help treat that disorder.

If you leave in a dry, arid climate, you can buy seeds that will grow and flourish in that climate. This is a great tool if you dont know what kind of seeds will grow well where you live. For research purposes, you cant beat this site.

You dont exactly always want people to know that you are growing marijuana. You also arent always in an area where it is easy to get marijuana seeds shipped to you. Thats where the Ministry of Cannabis comes in clutch. This service will ship to you no matter where you are in the world, and the packaging is discreet.

Although the site offers feminized and auto-flowering seeds, the site is really well-known for its CBD products. CBD products are great for reducing stress and anxiety as they help make you more mello.

If you arent sure what specific seeds you want, but you know what you want them to do, you can buy a packet of mixed seeds. For example, you can buy a packet of Indica seeds all of which can have different flavors and potencies. Its a great way to experiment with new seeds while having an idea of what the end product will be.

If you want high-quality weed seeds that grow quickly, look no further than Rocket Seeds. It is one of the top cannabis seed banks worldwide, offering feminized seeds, regular seeds, CBD seeds, and more.

They perform quality checks to ensure successful germination for weed seeds. However, no germination guarantee covers growing methods other than their recommended one.

Rocket Seeds offers international deliveries and will even ship to the USA. They accept various payment methods, including all major credit cards, cash, money transfers, Bitcoin, PayPal, and more.

Beaver Seed is a great spot to buy marijuana seeds online. It is a Canadian-based seed bank that carries feminized, auto-flowering, regular, and high CBD seeds all for a reasonable price. The seeds and strains have high germination rates, growing into flourishing marijuana plants that eventually produce flowers.

This company has a high level of production standards. The weed seeds are always inspected and carefully selected before being shipped.

Furthermore, Beaver Seeds regularly offers discounts and promotions, even on new marijuana strains.

Since 2007, Herbies Head Shop has been known as one of the best seed banks for cannabis enthusiasts. They offer a unique collection of seeds such as photoperiod seeds, high THC or CBD seeds, and fast flowering options.

Even with over 3,000 seeds for sale, all products are brand-only cannabis seeds that guarantee a harvest of the most potent marijuana. Plus, Herbies team of online consultants will gladly help you pick a seed bank or a specific strain if you need assistance.

Herbies also offers stealth shipping for maximum confidentiality. With this option, the marijuana seeds are removed from the original packaging, placed into Ziploc bags, and disguised as random items.

My Fast Buds is an excellent cannabis seed bank that has won several awards internationally. They specialize in auto-flowering cannabis plants, the ideal option for beginner growers.

All strain genetics are tailored for fast growth and have an impressive 98% germination guarantee. If a seed doesnt germinate, Fast Buds will send you free cannabis seeds as a replacement.

Fast Buds carries a total of 45 auto-flowering strains, including their best-sellers Gelato, Strawberry Pie, and Zkittlez.

Sonoma Seeds is a West Coast-based, premium cannabis seed supplier that distributes strains worldwide.

This online seed bank features a large seed selection from over 500 strains, including Indica seeds, hybrid seeds, Sativa seeds, CBD seeds, and more. They handpick everything and only offer high-quality marijuana seeds with an 80% germination rate.

Sonoma Seeds ships to customers worldwide and even offers free shipping for orders over $300. The site will accept various payment methods, including money transfers, e-transfers, cash, bitcoin, and major credit cards.

Seedsman started to sell cannabis seeds back in 2003. This company is a leader in the industry and remains at the forefront of cannabis innovation. For example, Seedsman was one of the first seed banks to commercialize auto-flowering and CBD genetics.

Its effortless to buy cannabis seeds online via the Seedsman website. They offer several categories of marijuana seeds such as feminized, auto-flowering, regular, high THC, high CBD, along with indoor and outdoor seeds.

All cannabis seed genetics are sourced from expert breeders worldwide, ensuring highly potent THC seeds and high-quality CBD cannabis seeds.

Seedsman also provides international shipping options, discreet packaging, updated order tracking, and various payment options. Additionally, the website has an informative blog where you can catch up on cannabis news, insights, and more.

If you are looking to buy seeds at a reasonable price then Sensible Seeds is your one-stop-shop. The site has a ridiculous amount of seeds for you to check out and purchase.

If you are looking for feminized, auto-flowering, medical-grade, or a high-CBD strain, there are seeds here with your name on them. Explore the hundreds of choices to find the ones that work best for you and at a price that wont break the bank!

As with other flowering plants, cannabis creates seeds that contain the genetic information needed for growth and reproduction.

Once the seed successfully germinates (or once the root has broken through the seed), it is ready to grow into a mature plant.

Cannabis seeds are around the size of a peppercorn, and most have light brown specks throughout the body.

Some cannabis on the market today does not contain seeds. In the middle of the 20th Century, growers realized that culling male plants once they displayed sex traits would only result in the crop containing unfertilized female plants.

It yielded cannabis plants with higher amounts of THC, plus they dont require the removal of seeds before smoking. These widespread advancements in cultivation practices have enabled seedless cannabis to be mass-produced and distributed throughout the globe.

You can find Cannabis seeds in several forms regular, feminized, and auto-flowering seeds. Most marijuana home growers prefer to grow feminized seeds.

Feminized seeds have been bred only to produce female plants. This matters for cultivation purposes. Female plants exclusively produce smokable flowers.

Regular seeds do not have this option. They produce male and female seeds, meaning there is no way to predict whether the mature plant will be female.

In addition to feminized marijuana seeds and regular seeds, some growers also use auto-flowering seeds. These seeds have been carefully engineered to begin and finish the flowering process without needing to be induced by changes in light throughout the day.

Auto-flowering seeds tend to be easier to grow since they dont require as much light as regular or feminized seeds, ideal for short or indoor growing seasons.

The legality of marijuana will depend on your location. Marijuana seeds are considered a cannabis-based product, meaning if you live in a place where marijuana is legal, then the seeds are also legal and vice versa.

If you want to buy cannabis seeds in a state where its illegal, you will face some degree of risk. There is a gray area where you can purchase marijuana seeds from seed banks as a souvenir, but this strategy is still dicey.

If you live in a weed-legal state (one where home growing is allowed), you should have no issue buying cannabis seeds online from a seed bank.

You have a couple of options, whether buying cannabis seeds online or in person. Cannabis seeds are sold in retail locations and through online seed banks. If you live in a country or state where cannabis use and growing marijuana is legal, you should buy the seeds at local dispensaries.

Furthermore, there are various online seed banks on the market. Choosing cannabis seed banks keenly is vital to ensure your investment does not go wasted. Many seed banks do not provide a germination guarantee, which is a critical step and should be a top priority when buying marijuana seeds online. If the germination process fails, so will everything else.

It largely depends on the vendor and the quality of the product. The price for your cannabis seeds will vary based on a few factors, including:

A package of marijuana seeds (which typically contains around 10 seeds) may run you anywhere from $40 for lower quality seeds and up to $400 or $500 for high-quality cannabis seeds.

You can expect high-quality cannabis seeds from this list of the best online seed banks. These well-established brands will not waste your money on cannabis seeds that did not even germinate. Ultimately, the decision will come down to your specific preference. You can consider variables such as seed types, shipping times and costs, and whether the vendor offers multiple payment methods. Overall, you cant go wrong with these reputable seed banks.

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10 Best Seed Banks 2022: Top Cannabis Seed Banks That Ship to USA - Washington City Paper

April 12, 2022

Given the state of the planet, is it OK to have a child? With so much grim climate news, can we allow ourselves to feel optimistic? If we talk with people from around the world, can we gain new insights on how climate change is affecting their lives?

These are some of the questions raised and answered by the winning writers of the first biennial Climate Narratives Prize, to be awarded at Arizona State University on April 22, Earth Day, at an event titled Hope, Alarm and Climate Change. Photo by iStock Download Full Image

The winners and two special mentions were selected from a collection of nominated works, exemplifying the best published narratives of the last five years that explore the reality and impact of our current climate crisis and the state of our planet and society.

The three top winners will receive cash prizes of $5,000, $2,000 and $1,000, respectively.

The prize created and sponsored by ASUs Julie Ann Wrigley Global Futures Laboratory, the Center for the Study of Religion and Conflict, and the Narrative Storytelling Initiativeoriginated as part of a project to rethink how climate change stories are told and explore their potential to drive social and cultural change. The project drew on the expertise of journalists, climate scientists and scholars of the humanities to better conceptualize and communicate through story the world-shattering stakes of inaction on climate change.

The winning narratives were chosen from nominations submitted by such renowned writers, thinkers and activists as Bill McKibben, Katharine Hayhoe, Wendell Berry, Vann R. Newkirk II, Frank Sesno, Kyle P. Whyte and Lacy M. Johnson.

The nominations were then reviewed and voted on by graduate students in a multidisciplinary course at ASU called Climate Narratives, Apocalypse and Social Change, developed with the support of a Luce Foundation/ACLS-funded grant and taught by ASU professors Steven Beschloss and Sarah Viren.

Weve launched this Climate Narratives Prize to shine a light on climate-related writing that can have an impact on the publics thinking and choices, said Beschloss, who is also the founding director of ASUs Narrative Storytelling Initiative and narratives lead for the Julie Ann Wrigley Global Futures Laboratory. It is clear it will take creative thinking and multiple modes of storytelling to expand the publics awareness and commitment to change.

To prepare for selecting honorees, we read widely and thought deeply about what it means to write toward social change, and students used that knowledge to evaluate each nomination, added Viren, an assistant professor of creative nonfiction. This process taught all of us to think more creatively about what it means to influence the way people think about an issue.

The public announcement and celebration of the winners will take place April 22 from 11:45 a.m.1:15 p.m. Arizona time in ASUs newest research building, ISTB7, dedicated to planetary and societal health.

Featured speakers include all three winners and several nominators in a conversation moderated by Beschloss and Viren. The event will include reflections on the issues surrounding climate change, the kinds of narratives that can drive impact, and the spectrum of storytelling from alarm and despair to optimism and hope.

Learn more about the Climate Narratives Prize and the project.

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Why some people become addicted and others don't - ASU News Now

Everyone considers sperm to be made exclusively by males. But did you know that females also make sperm? Well, it turns out that females also contribute to what makes a sperm a sperm. Nearly 20 percent of couples in the United States fail to conceive naturally after one year of trying, according to theCenters for Disease Control and Prevention. In species with internal fertilization, such as humans, the ability for a female to become pregnant and carry a pregnancy to term is dependent upon effective interactions between sperm and the female reproductive tract (FRT). When those interactions are defective, the result can be a failed pregnancy. Therefore, understanding the factors that contribute to sperm viability between copulation and fertilization is crucial.

Pictured are spermatozoa of Drosophila melanogaster within a females specialized sperm-storage organ, where they await the opportunity to fertilize ova. (Image courtesy: Scott Pitnick)

A research team from the College of Arts and SciencesDepartment of Biologyand Cornell University, led by Steve Dorus, associate professor of biology at Syracuse University, have been studying the life history of fruit fly (Drosophila melanogaster) sperm to better understand molecular continuity between male and female reproductive tracts. In other words, how the male and female reproductive tracts provide support to keep the sperm viable before fertilization. Their results, recently published in the journalProceedings of the National Academy of Sciences USA(PNAS), shed light on important events that may play a role in infertility that up until now have been poorly understood.

The team, which includes members from the Universitys Center for Reproductive Evolution, explored the compositional changes in fruit fly sperm, beginning shortly after they leave the testis, following insemination and finally after protracted storage within the FRT. Fruit flies are powerful model organisms for investigations such as this one because they are easy to culture in the laboratory, have a short generation time and their genetics are richly understood. In their study, the group uncovered that the proteome, or protein makeup, of the sperm undergoes substantial changes after being transferred to the FRT.

For species with internal fertilization, a sperms developmental journeyon the way to its final destination of fertilizing an egg and beginning a new lifetranscends both male and female reproductive tracts. After leaving the testis, sperm travel through the males seminal vesicles and descend through the ejaculatory duct, where they mix with seminal fluid proteins. The team found that many of these seminal proteins are progressively lost after sperm migrate beyond the site of insemination within the FRT. Conversely, female-derived proteins that may help the sperm with functions such as energy metabolism, begin to associate with the sperm immediately after mating, signifying a changing of the guard of proteins. After several days of storage within the FRT, the research team was surprised to discover that nearly 20 percent the sperms proteins had been replaced by female-derived proteins. The female contributions support sperm viability during the prolonged period between copulation and fertilization. This hand-off in the maintenance of sperm viability from males to females means that sperm are materially the product of both sexes, and this may be a crucial aspect of reproduction in all internally-fertilizing species, including humans.

By studying the intimate ways in which sperm interact with the FRT during the final stages of functional maturation, the teams research advances understanding of animal fertility and the contributions of each sex to reproductive success.

Their research, which appears in the March 15 issue of PNAS, was chosen as that editions cover art, signifying the high impact of their work. The photo was captured by co-author and biology Professor Scott Pitnick, and provides a close-up view of sperm within an organ specialized for sperm storage in a female reproductive tract of Drosophila melanogaster.

In addition to Dorus and Pitnick, other co-authors from Syracuse University included former postdoctoral researcher Erin McCullough and doctoral graduate Emma Whittington. Co-authors from Cornell University were Professor Mariana Wolfner and postdoctoral researcher Akanksha Singh. The teams research was funded by the National Science Foundation, the National Institutes of Health and a gift from Mike and Jane Weeden to Syracuse University.

Read the teams full paper, The life history of Drosophila sperm involves molecular continuity between male and female reproductive tracts.>PNAS is the official journal of theNational Academy of Sciences(NAS), and is an authoritative source of high-impact, original research that broadly spans the biological, physical and social sciences.

Link:
A&S Biologists Observe Molecular 'Hand-off' That Plays Key Role in Reproduction - Syracuse University News

Ancient skeletons, funerary practices, and DNA reveal layers of inequality in past societies.

November 26, 1922, marks what is arguably the most famous discovery in the history of archaeology. On that day, the British Egyptologist Howard Carter made a small hole through which he could insert a candle in the sealed doorway of Tutankhamuns burial chamber and thus lit the interior. As his eyes slowly adapted to the darkness, he was able to make out a chamber that had not been disturbed for over 3,000 years.

Tutankhamun was just an obscure pharaoh during his lifetime, and there is evidence that he was hastily buried; the second of the three nested coffins seems to have originally belonged to someone else. And yet the inner coffin, in which his mummy was discovered, is made of solid gold, weighing almost 250 pounds. One can barely imagine how impressive the burials of such powerful leaders as Khufu, Thutmose III, or Rameses II must have been; alas, they were all looted in antiquity.

But contrary to popular belief and cinematic glorification, most archaeologists would say that the search for spectacular treasures isnt their main research objective; they want to understand the daily life of past civilizations. Still, both extremes the fabulous wealth of kings and the hardscrabble existence of common people contribute to an understanding of what can be argued is one of the main goals of archaeology: to document and study the evolution of inequality in ancient societies. This also involves the question of how to recognize and quantify it.

One of the most obvious approaches would be through the assessment of differential goods deposited in graves. But richly furnished graves may not simply be evidence of social differentiation; rather, they may be an attempt to demonstrate the importance and distinction of a family in relationship to other kindreds a social importance that may not exist in reality. Moreover, social stratification can be based on wealth but can also be based on personal prestige and power. Therefore, it isnt always possible to assess social differences by comparing graves with goods to those without them.

Aztec society, even with its horrific human sacrifices, was at the time of the Spanish conquest more egalitarian than Mexico 200 years later.

Some archaeologists have attempted to apply economic principles to examine social differences at specific sites and, crucially, compare the data from different places. A study led by Samuel Bowles from the Santa Fe Institute and published in Nature in 2017 tried to address this question by applying the Gini coefficient a single number most commonly used to measure income inequality across a large number of sites from the archaeological record, both in the Old World and the Americas. The list of sites included paradigmatic cities such as atalhyk in Turkey, Pompeii in Italy, and Teotihuacan in Mexico; the authors measured the dimensions of houses as estimated indicators of wealth.

Among modern hunter-gatherers, the team found, the Gini coefficient is low around 17 (on a scale of 0 to 100). This is not surprising as few objects can be carried in nomadic societies, and consequently, personal qualities such as the ability to hunt count for more. This does not mean that some people didnt have a higher social status; material culture was probably so poor or so different from our perceptions of status that it is difficult to grasp social differences among past hunter-gatherers.

In the ancient farming societies under study the Gini coefficients are estimated to have been between 35 and 46; interestingly, the real measurements were lower than those obtained from records. For instance, among the ruins of Babylonia, researchers estimated a coefficient of 40, yet an estimate based on information from the Babylonian chronicles resulted in a higher coefficient of 46. The ancient accounts likely overemphasized the size of the largest houses in admiration. This is not unlike what happens when we return from a trip: We sometimes tend to exaggerate the things that weve seen.

Nevertheless, the most remarkable differences come from the comparison of the societies of the Old World and those of the Americas, with the latter being much more equal in the Gini coefficient, despite being highly hierarchical in some cases such as the mighty Aztec Empire. Researchers conclude that the root of these differences could be ecological since there were more and larger animals to be domesticated in Eurasia such as cows, horses, pigs, sheep, and goats than in the Americas, with only dogs and turkeys, and this trait alone created a differential system of accumulated wealth.

At the Aztec capital, Tenochtitln, for instance, houses had highly standardized dimensions and were all quite similar. Aztec society, even with its horrific human sacrifices, was at the time of the Spanish conquest more egalitarian than Mexico 200 years later, when the European elite had created the encomienda system, under which the indigenous population worked in semislavery. Within a few generations, the concentration of wealth had almost doubled in the colonial New World, with a consequent increase in inequality.

When did these differences between the Old and New Worlds emerge? Early farming societies had the possibility of generating and storing food surpluses, creating potential scenarios for differences in population size along with a certain degree of inter- and intrasettlement inequality. A recent application of the Gini coefficient to 90 sites from the Near East and Europe showed a remarkable increase of inequality thousands of years after the advent of agriculture a finding that would indicate it was not farming per se that created unequal societies. According to the authors, at some point some farmers were able to maintain specialized plow oxen that could cultivate 10 times more land than other farmers, thereby transforming the economy toward a higher value of land in detriment of human labor.

This emerging inequality at the end of the Neolithic could explain a remarkable example of wealth dating from that period: the Varna burial. This burial was found in a Copper Age cemetery in modern Bulgaria and is dated to 45604450 BCE; it contained more gold than the rest of the world possessed at that time. It contained an adult male likely a chieftain or king of some sort who was buried holding a gold war mace; curiously he also had a gold penis sheath of unknown meaning. Still, such findings are exceptional, and there is a general consensus that Neolithic societies were more egalitarian than later ones.

Inequality clearly increased with the arrival of metals, which partly allowed, from 3000 to 2000 BCE onward, the appearance and development of a social organization based on the emergence of elites. Once the initial power structure was established, it attempted to perpetuate itself dynastically by increasing social control and building up familial alliances with other chiefs. Control mechanisms often involved violence. The possibility of using horses and to lesser extent, camels as instruments of war determined the success of conquests that would alter the pattern of settlements across Eurasia at the end of the Neolithic. This would at least partially explain how 30 empires or large states that emerged between 3000 and 600 BCE were all found in the Old World, where these animals roamed.

Consequently, tombs with signs of wealth became more abundant in the archaeological record, such as the famous Amesbury Archer, found three miles southeast of Stonehenge in 2002 (near todays Salisbury) and dated to 2300 BCE. This grave includes more artifacts than any other Bronze Age British burial; besides numerous arrowheads, three copper knives, four boars tusks, two stone wrist guards that protected users from their bowstrings, and five pots that conformed to the Bell Beaker tradition, there were two gold hair ornaments the earliest pieces made of this metal ever found in the British Isles. The arrival of the Bell Beaker complex to the British Isles is associated with an almost complete replacement of the prior local population and subsequent emergence of social elites. The Amesbury Archer must be considered in the context of the spread of metalwork and supraregional exchange networks in a process that archaeologists sometimes call Bronzization.

The rise in inequality during this period, both in the Middle East and parts of western Europe, seems to be partly influenced by an increase in population density. This correlation is likely related to a growing complexity in modes of subsistence, trading networks, and political organization associated with population growth.

Although the highest Gini coefficients for past societies determined by the Santa Fe Institute were similar to those found in some present-day European countries (for instance, with values of around 60 in Pompeii and Kahun, an Egyptian settlement from the 12th dynasty), they remained below the values for the most unequal modern societies such as China and the United States (with Gini coefficients of 73 and 85, respectively), which obviously have larger populations.

From a historical perspective this would suggest that an increase in population size brings higher inequality an issue explored by the economist Thomas Piketty in recent times, but that likely has parallels in Bronze Age populations.

Still, the Gini coefficient cannot always be applied since some settlements have grown with time over the destruction of previous ones, piled one atop another like the layers of a cake. Many ancient sites could not possibly be studied in detail; for instance, at Hisarlik the old Troy at least 10 cities arose atop their predecessors in just 2,000 years, making them quite difficult to disentangle. In addition to this limitation, whether the Gini coefficient can be transferred between different cultural, geographic, and ecological environments to make direct comparisons has also been a subject of debate since such factors can influence their inhabitants differently. For example, a settlement established in a jagged terrain would favor smaller, more vertical houses than one extending over a vast plain.

The economic interpretation of past settlements has received some criticism from among the archaeological community; some argue that the quality and solidity of the building materials can be as important as the size of the houses. In our modern cities, were all aware that location for instance, close to the city center is usually more important than size. Finally, the ostentatious wealth opulent furniture, wall paintings, mosaics, and so on that can still be found in some excavated houses such as at Pompeii should be taken into consideration too, though such features arent usually well preserved.

One way around these limitations might be to compare the Gini coefficients with the so-called health inequality of each population, since buried human remains are sometimes better preserved than buildings. There are several skeletal indicators (dental cavities, arthrosis, traumas, vitamin deficiencies, etc.) that can reflect the health status of the population in each period. The frequencies of these pathological markers are in general higher during periods of higher inequality.

For example, the 20062013 excavation of nonelite cemeteries such as North Tombs Cemeteries at Amarna demonstrated deaths at an early age mainly of children, teenagers, and young adults widespread dietary deficiencies, and indications of hard labor, suggesting the poor state of health and substandard working conditions for most of this urban community. For instance, 16 percent of all children under 15 displayed spine injuries of the sort associated with carrying heavy loads; none of them had any grave goods, and sometimes were buried together with several others, with scant regard for the disposition of the bodies a grim image that contrasts with the glamorous depictions of the pharaohs family in the Amarna style.

The information retrieved from their DNA can be used, for the first time, to correlate ancestry with social power in each period.

An additional indicator would be evidence of a high infant mortality rate, although the preservation of childrens skeletal remains is invariably more difficult than that of adult bones due to differential conservation processes, and this could represent an insurmountable bias in the results. Changes in health status can be used to ascertain cultural and ancestral transitions too. In this sense, probably the most striking change observed is between hunter-gatherers and the first farmers in Europe. The latter not only show signs of poorer health such as cavities, almost unknown by the former but also higher infant mortality rates and even lower stature than previous hunter-gatherers.

Correlated with this information, recent developments in the stable isotope analysis of carbon and nitrogen ratios in bone collagen can provide information on nutritional status and mobility patterns associated with specific individuals. For instance, the analysis of a high-status burial in Helmsdorf, Germany, related to the ntice culture, showed that this person had a higher protein intake than other contemporaneous peers, suggesting as well that diet can be as much an indicator of social status as it is in todays societies.

Key to understanding the social panorama of the past is that ancient cemeteries can provide not only potential indicators of inequality in the form of grave goods and even differential health status but also genetic material preserved within human remains. The information retrieved from their DNA can be used, for the first time, to correlate ancestry with social power in each period. Furthermore, a crucial aspect of the accumulation of power is the possibility of bequeathing wealth to biological relatives something that can be tested as well via the interface between genetics and archaeology, which enables us to reveal family links.

Like funerary goods, a privileged resting place could serve as a status marker too. Around 6,500 years ago, the phenomenon of building large funerary stone structures known as megalithic tombs emerged, mainly across Europes Atlantic seaboard, and culminated in the great passage tomb complexes such as Newgrange in Boyne Valley (Ireland), which has a mound almost 300 feet in diameter and 50 feet high. The origins and meaning of these monuments, which required a heavy investment in labor, have been debated for more than a century, as has the social organization of the farming communities that built them. The genetic analysis of two-dozen individuals found in various megalithic tombs from Scandinavia to Orkney Island and Ireland yielded some interesting social clues.

In some places, notably the British Isles, more males than females were buried in these preeminent spots, pointing to a sex bias. In accordance with this observation, the descent of most individuals with kinship links could be traced through the paternal line. In one case it was possible to find two related males buried in two different megaliths just over a mile apart (Primrose Grange and Carrowmore in Ireland), indicating a geographic expansion of these dominant families. Genetic analyses of skeletal remains discovered within the most intricately constructed chamber of the Newgrange passage tomb revealed that they belonged to the incestuous son of a brother and sister (or a parent and child), and therefore a quarter of his genome had no genetic variation.

The fact that even children who died in infancy were buried with grave goods suggests as well that their status was inherited rather than acquired during their lifetime.

This kind of first-degree offspring is extraordinary, only having been cited in royal families of the past headed by god-kings such as the Egyptian pharaohs seeking to maintain a pure dynastic bloodline. (It is known, for instance, that Akhenaten married his eldest daughter, Meritaten, and much later, Ptolemy II married his sister, Arsinoe II hence his nickname, Philadelphus or sibling loving.) It has been suggested that this Neolithic elite may have claimed to possess divine powers to ensure the continuity of agricultural cycles by keeping the suns movements going.

The findings support the notion that these Neolithic communities were socially stratified and that the massive stone structures were used to bury transgenerational patrilineal members of these clans. Perhaps equally interesting is the fact that in one case relatives were separated by up to 12 generations, pointing to an unusual stability through time of both the funerary tradition and the stratified society where they lived.

One of the most illustrative examples of how the analysis of Bronze Age individuals that lived through continental-scale cultural changes can shed light on the process is a study led by researchers at the Max Planck Institute in Jena and published in 2019. Paleogenetic researchers analyzed more than 100 skeletons from 45 farmstead-related graveyards in the Lech River valley in southern Germany to explore the social mechanisms underlying the local spread of steppe ancestry across Europe. Additionally, isotope data were generated for these individuals to gather information on their lifetime mobility patterns, which could be correlated with differential composition in genetic ancestry.

Isotopic analyses revealed that females tended to be nonlocal (only 50 percent of them had values consistent with the local isotopic range) as compared to males and children from the same cemeteries (where 82 to 84 percent were deemed local). Isotopic data on early and late forming teeth in the same individuals the first and third permanent molars that emerge at six and 18 years, respectively suggested that females moved from their birthplaces during adolescence or later. One of them was found to come from a place at least 200 miles away. Most of the males carried the R1b Y chromosome lineage, while the mitochondrial DNA lineage composition was much more diverse. The results indicate that these Bronze Age settlements followed patrilocal residential rules that is, males stayed in the groups where they were born, while females moved away from them. The fact that most males descendants shared their ancestry with a single female also suggests that the social structure, besides being based on patrilineal links, was likely monogamous.

The researchers were able to reconstruct six pedigrees in different graveyards, three of which spanned at least four generations. They detected 10 parent-offspring relationships, six of them between mother and child. Interestingly, the latter were always male; there were no adult daughters present. Again, this suggests that females were interchanged between households as a way to establish alliances; it is likely that their status was secured once they had children in the new household. It was also possible to correlate grave goods (daggers, axes, chisels, and arrowheads for males, and body ornaments such as neck or leg rings for females) with kinship.

This indicates that wealth and social status were inherited and ran with families. The fact that even children who died in infancy were buried with grave goods suggests as well that their status was inherited rather than acquired during their lifetime. A further observation was that members of each clan were buried near each other in the cemeteries, thus clearly delimiting preeminent areas within them. It is likely that the inheritance system of these households was based on male primogeniture a custom by which the oldest son inherits all the familys properties at the fathers death. With time, forged alliances granted families access to larger, regional clans and eventually kingdoms.

An examination of the dynamics between kinship and social inequality can be applied to even more recent periods. The complex interactions underlying extended families and population levels can be better understood in geographically isolated places such as islands. Iceland remains the most studied island from a genetic point of view, mainly due to the efforts of a private company called deCODE Genetics that was founded in 1996 by neurologist Kri Stefnsson.

Iceland, a remote island in the north Atlantic, was first colonized around 874 CE, according to the Landnmabk, or settlement book, when the Norse chieftain Inlfr Arnarson arrived in the region of present-day Reykjavik. Over the next 150 years, groups of Viking migrants from Norway along with Celtic women and servants or slaves arrived on the island, establishing themselves on rather isolated farms. By 930 CE, all arable land was already occupied and all the forests were gone. The migratory influx slowed down afterward and almost ceased after the year 1000 CE. This resulted in a population that was small and isolated yet at the same time big enough to have all the common European diseases and genetic diversity and it suffered several demographic bottlenecks associated with volcanic eruptions, famines, and epidemics of the plague.

Until 1850, the Icelandic population never exceeded 50,000. The combination of two factors an isolated population and a well-known genealogical database makes Iceland an ideal laboratory for detecting genetic variants associated with common diseases that affect not only modern Icelanders but also the rest of Europe, where such information does not exist or the population is too big to make such an approach practical. Over the years, researchers from deCODE Genetics have generated a whole body of data on the genomics of modern Icelanders and also on how the original population was established. By working with uniparental markers from living Icelanders it could be observed that 62 percent of the mitochondrial DNA was Celtic in origin (meaning that the majority of these maternal markers derived from either the British Isles or Ireland), while 75 percent of the Y chromosomes were of Scandinavian origin. This suggested a settlement primarily established by Viking males and Celtic females.

In 2017, and thanks to paleogenomic techniques, it was possible to retrieve 27 ancient Icelandic genomes, most of them from the heathen period (prior to the year 1000 CE, when Icelanders decided to become Christians by the curious procedure of voting). At the nuclear genome level, these pioneers had a Norwegian-type ancestry (55.4 percent) that was greater than the Celtic one, and more prevalent among men (a recent genetic study of more than 400 Viking individuals has confirmed the spread of Norwegian ancestry mainly across the North Atlantic islands).

Modern Icelanders are not, however, a simple mixture of the two components; their ancestry demonstrates a differentiation from the two source populations at least partially due to genetic drift promoted by geographic isolation during the last thousand years. Interestingly, the Norwegian-type ancestry component in Iceland is nowadays 70.4 percent, suggesting an increase that was likely socially mediated. An example of this stems from seven individuals excavated in 1964 from a boat grave (a type of burial in which a ship is used as a container of the dead) at Vatnsdalur in the remote western fjords. The grave goods included a knife, 30 beads, a silver Thors hammer, a Cufic coin (dated circa 870930 CE), and various items of jewelry. Three of the four skeletons sequenced showed mostly Scandinavian ancestry. One of these individuals is among the few sequenced early settlers to be genetically similar to modern Icelanders, indicating that he contributed disproportionately to their ancestry.

One way or another, mortuary archaeology will always be an important subfield of this discipline, and one that will need to rely on the hard sciences such as genetics and forensics.

It seems that the Celtic servants brought to Iceland clearly had fewer opportunities to reproduce. Using isotopic analysis, it was also possible to detect that at least three people two Scandinavians and one Celt were first-generation migrants, having spent their childhood outside Iceland. One individual had mixed ancestry, indicating that his parents were from different places. The fact that the Celtic ancestry is still detectable decades after the first settlement also suggests that some kind of social discrimination between the two ancestral groups persisted for a while. After a few centuries, however, the admixing of the two communities was complete, to the point that Iceland has essentially become an extended family with a remarkably uniform population.

We have seen several case studies of past inequality correlating funerary archaeology with genetics that might no longer apply today, where legal regulations (and also the exponential increase of cremations) represent a certain degree of standardization in funeral practices. Nevertheless, an opposite trend could shape the future of the archaeology of death: the trend toward personalized coffins, unconventional funerary memorials, and special grave goods. One way or another, mortuary archaeology will always be an important subfield of this discipline, and one that will need to rely on the hard sciences such as genetics and forensics.

Perhaps one encouraging conclusion is that despite what we have seen on the archaeology of past inequality, societies have been able to evolve and change their social stratifications. One example is Iceland itself; the country has become one of the most egalitarian societies in the world. In 2018, Iceland passed a law that all companies employing more than 25 people will have four years to ensure gender-equal payment because, according to the head of the Equality Unit at Icelands Welfare Ministry, equality wont come about by itself, from the bottom up alone.

Carles Lalueza-Fox is Research Professor and Director of the Paleogenomics Lab at the Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra) in Barcelona. He participated in the Neanderthal Genome Project and led the first retrieval of the genome of an 8,000-year-old European hunter-gatherer. He is the author of Inequality: A Genetic History, from which this article is adapted.

More here:
The Archaeology of Inequality - The MIT Press Reader

To the Editor:

Re Pills Are New Target in 50-Year Abortion Battle (front page, April 6):

The game plan of the anti-abortion movement is falling into place. First, impose strict restrictions on the surgical procedure (think Texas and Oklahoma). Next, let the Supreme Court jettison Roe v. Wade. And now, we read that abortion pills are the new battle line, as numerous states have adopted or are considering restrictions and penalties for pill takers and pill providers.

I am convinced that, after the surgery and the pills are gone, the next target will be birth control.

Abortion opponents, determined to impose their religious views upon the country at large, will not rest until all American women can experience the joys of living in the 13th century.

William DunhamBryn Mawr, Pa.

To the Editor:

Its time for a modern-day Underground Railroad to obtain self-medicated abortions. Its time to widely advertise the availability of these pills, and explain their safety, effectiveness and cost (much cheaper than a medical abortion). You report that in 2020, 54 percent of abortions were with these pills.

Tell women how to obtain these pills from Europe, Canada and Mexico. Attempts to ban pills via the mail will be futile. We need an underground movement to counter state efforts to stop abortions.

Steve GoldPhiladelphia

To the Editor:

Re Near-Total Ban on Abortion in Oklahoma (news article, April 6):

The near-total ban on abortion was approved by a male-dominated legislature. Oklahoma has among the lowest percentages of female legislators in the country.

These men dont seem to get that it takes two people to make a baby. While this law is meant to control the behavior of women, I know of no law that exerts any control over the behavior of the men who are fathering these children.

Martha MeyerChicago

To the Editor:

In the spring of 2005, while we were living in Tulsa, Okla., my wife became pregnant. However, our joy turned to concern and then sorrow as the fetal heartbeat slowed and eventually stopped. My wife had miscarried.

After consulting with our obstetrician, my wife decided to have a dilation and curettage procedure. We both hoped that by surgically extracting the fetal tissue rather than waiting for it to pass on its own, she would heal faster physically and psychologically.

A few weeks later, I received a letter from our insurance company, informing me that the procedure was not covered because it did not pay for abortions. My wife did not have an abortion, and she did not willingly terminate her pregnancy. After many letters and phone calls, I sorted out the situation with our insurance carrier.

However, under the bill passed by Oklahoma lawmakers, that simple insurance coding error or misunderstanding could have led to the arrest of my wifes physician. I suspect that many innocent people, providing appropriate health care to the women of Oklahoma, will face legal consequences as a result of this legislation.

James MonkCleveland

To the Editor:

Re Save Baseball by Nationalizing It, by Matthew Walther (Opinion guest essay, Sunday Review, April 10):

I grew up playing Little League Baseball and, later, N.C.A.A. softball. If my children dont play baseball, it wont be because the game is slow or uncool. Itll be because youth sports have become exorbitantly expensive, and as a result socioeconomically monolithic, shutting out a generation of enthusiasm and talent.

After equipment, uniforms, travel fees and hotels, youth baseball can cost families thousands of dollars per child, and thats if they live near a baseball field unlikely in a dense city or have jobs that allow them to drive their children to practice. Why go through the rigmarole when kids can play football in the park?

It makes sense, then, that Major League Baseballs fan base is overwhelmingly older and whiter even as America becomes younger and more diverse.

Baseball doesnt have a relevance problem. It has an equity problem. To survive as the American pastime, baseball needs youth leagues that are financially, geographically and socially accessible to American kids, and professional rosters that better represent the country.

And speaking as a girl who used to strike out the boys involving more women and girls wouldnt hurt.

Maddie UlanowCambridge, Mass.

To the Editor:

Baseballs future was sealed when, to maximize short-term revenues, it started broadcasting the World Series at night, too late for many young fans to watch. When you cant watch the World Series, it becomes hard to become a die-hard fan.

Rather than nationalize, why not return the World Series to daytime? It has a better chance of saving the game.

Chris BarnumWilmington, Del.

To the Editor:

Re Straight People Need Better Rules for Sex, by Christine Emba (Opinion guest essay, Sunday Review, April 10):

One concerning aspect of sexual encounters raised by Ms. Emba is the use of choking, say, or other porn-inspired violence.

As a psychotherapist and a couples counselor, I am seeing more and more young heterosexual couples where the use of choking and other acts that are violent or degrading to women has caused a significant rift in the relationship.

One suggestion I have for young men is to ask a question three times to get a true answer. Perhaps by asking three times we create that pause suggested by Epictetus. It might sound like: Is this OK? Is it really OK with you? Are you sure you want to do this?

As a society we need to teach men how actual sex with an actual woman might differ from the hard-core porn theyve been exposed to, and we need to educate men about what it means to bring respect, true consent and pleasure into the bedroom in a way that a woman might want.

Jennifer WoffordBrookline, Mass.

To the Editor:

The whole species needs better mores for social intercourse. Maybe we should mainstream manners. Courtesy dignifies our own and others value.

Deborah GriesbachWatertown, Conn.

To the Editor:

Re America Is Running Out of Money to Fight Covid, by Vivek H. Murthy and David A. Kessler (Opinion guest essay, nytimes.com, March 29):

The U.S. surgeon general and the chief science officer for the U.S. Covid-19 Response Team write that the federal government is running out of money to provide Americans with Covid-19 vaccines, booster shots and other supplies to address present and future risks from variants of the coronavirus. They write, It would be a grave mistake to assume Covid-19 no longer requires our action and investment.

As professors of health policy, we strongly agree that the risks are still substantial and likely to increase with a future variant. But our research, published in the Journal of the Royal Society of Medicine, shows that the U.S. is paying Pfizer, Moderna and other major companies more than 15 times the companies total net costs per dose, after subtracting the billions taxpayers already paid them for developing and manufacturing them. More than 95 percent of the $23 to $25 a dose the government now pays is pure profit for executives and shareholders.

If the government paid net costs plus a 20 percent profit, it would have plenty of money to fund its Covid-19 program and would be able to greatly increase global equity access.

Donald W. LightJoel R. LexchinDr. Light is a professor at the Rowan University School of Osteopathic Medicine. Dr. Lexchin is an emergency physician and professor emeritus at York University.

Link:
Opinion | Fighting the Latest Efforts to Outlaw Abortion - The New York Times

Amsterdam, E. A. et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 130, 23542394 (2014).

Google Scholar

Kernan, W. N. et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 45, 21602236 (2014).

Google Scholar

Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC) et al. ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur. Heart J. 33, 25692619 (2012).

Google Scholar

Parodi, G. et al. High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI. JAMA 306, 12151223 (2011).

CAS Google Scholar

Papathanasiou, A., Goudevenos, J. & Tselepis, A. D. Resistance to aspirin and clopidogrel: Possible mechanisms, laboratory investigation, and clinical significance. Hellenic J. Cardiol. 48, 352363 (2007).

Google Scholar

Mallouk, N. et al. Prevalence of poor biological response to clopidogrel: A systematic review. Thromb. Haemost. 107, 494506 (2012).

CAS Google Scholar

Wei, Y.-Q., Wang, D.-G., Yang, H. & Cao, H. Cytochrome P450 CYP 2C19*2 associated with adverse 1-year cardiovascular events in patients with acute coronary syndrome. PLoS ONE 10, e0132561 (2015).

Google Scholar

Jia, D. et al. CYP2C19 polymorphisms and antiplatelet effects of clopidogrel in acute ischemic stroke in China. Stroke 44, 17171719 (2013).

CAS Google Scholar

Berger, J. S. et al. Smoking, clopidogrel, and mortality in patients with established cardiovascular disease. Circulation 120, 2337 (2009).

CAS Google Scholar

Silvain, J. et al. High on-thienopyridine platelet reactivity in elderly coronary patients: The SENIOR-PLATELET study. Eur. Heart J. 33, 12411249 (2012).

CAS Google Scholar

Labarthe, B., Throux, P., Angio, M. & Ghitescu, M. Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug. J. Am. Coll. Cardiol. 46, 638645 (2005).

CAS Google Scholar

Sangkuhl, K., Klein, T. E. & Altman, R. B. Clopidogrel pathway. Pharmacogenet. Genomics 20, 463465 (2010).

CAS Google Scholar

Hulot, J.-S. et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 108, 22442247 (2006).

CAS Google Scholar

Brandt, J. T. et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J. Thromb. Haemost. 5, 24292436 (2007).

CAS Google Scholar

Giusti, B. et al. Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet. Genomics 17, 10571064 (2007).

CAS Google Scholar

Trenk, D. et al. Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents. J. Am. Coll. Cardiol. 51, 19251934 (2008).

CAS Google Scholar

Fontana, P., Senouf, D. & Mach, F. Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19*2 allele on clopidogrel responsiveness. Thromb. Res. 121, 463468 (2008).

CAS Google Scholar

Gaedigk, A. et al. The pharmacogene variation (PharmVar) consortium: Incorporation of the human cytochrome P450 (CYP) allele nomenclature database. Clin. Pharmacol. Ther. 103, 399401 (2018).

CAS Google Scholar

Sibbing, D. et al. Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention. Eur. Heart J. 30, 916922 (2009).

CAS Google Scholar

de Morais, S. M. et al. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J. Biol. Chem. 269, 1541915422 (1994).

Google Scholar

Botton, M. R. et al. PharmVar GeneFocus: CYP2C19. Clin. Pharmacol. Ther. 109, 352366 (2021).

Google Scholar

Ferreiro, J. L. & Angiolillo, D. J. Clopidogrel response variability: Current status and future directions. Thromb. Haemost. 102, 714 (2009).

CAS Google Scholar

Chan, M. Y. Clopidogrel pharmacogenetics of east, south and other Asian populations. Eur. Heart J. Suppl. 14, A41A42 (2012).

CAS Google Scholar

Abid, L. et al. Impact of cytochrome P450 2C19*2 polymorphism on the clinical cardiovascular events after stent implantation in patients receiving clopidogrel of a southern Tunisian region. World J. Cardiovasc. Dis. 3, 410 (2013).

Google Scholar

Mller, I. et al. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb. Haemost. 89, 783787 (2003).

Google Scholar

Angiolillo, D. J. et al. Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting. Thromb. Res. 115, 101108 (2005).

CAS Google Scholar

Varenhorst, C. et al. Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease. Eur. Heart J. 30, 17441752 (2009).

CAS Google Scholar

Mrginean, A., Bnescu, C., Scridon, A. & Dobreanu, M. Anti-platelet therapy resistanceConcept, mechanisms and platelet function tests in intensive care facilities. J. Crit. Care Med. 2, 615 (2016).

Google Scholar

Mega, J. L. et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N. Engl. J. Med. 360, 354362 (2009).

CAS Google Scholar

Rath, P. C. et al. A study on the impact of CYP2C19 genotype and platelet reactivity assay on patients undergoing PCI. Indian Heart J. 67, 114121 (2015).

CAS Google Scholar

Bhatt, D. L. et al. The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: The CHARISMA genetics study. Eur. Heart J. 33, 21432150 (2012).

CAS Google Scholar

Kim, K. A., Park, P. W., Hong, S. J. & Park, J.-Y. The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: A possible mechanism for clopidogrel resistance. Clin. Pharmacol. Ther. 84, 236242 (2008).

CAS Google Scholar

Osmancik, P., Paulu, P., Tousek, P., Kocka, V. & Widimsky, P. High leukocyte count and interleukin-10 predict high on-treatment-platelet-reactivity in patients treated with clopidogrel. J. Thromb. Thrombolysis 33, 349354 (2012).

CAS Google Scholar

Mannini, L. et al. Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients. Clin. Hemorheol. Microcirc. 35, 175181 (2006).

CAS Google Scholar

Li, L. et al. Clopidogrel resistance of patients with coronary artery disease and its correlation with platelet count and mean platelet volume. Zhonghua Yi Xue Za Zhi 93, 916920 (2013).

CAS Google Scholar

Uzun, F. et al. Antiplatelet resistance and the role of associated variables in stable patients treated with stenting. Postepy Kardiol Interwencyjnej 11, 1925 (2015).

Google Scholar

Angiolillo, D. J. & Suryadevara, S. Aspirin and clopidogrel: Efficacy and resistance in diabetes mellitus. Best Pract. Res. Clin. Endocrinol. Metab. 23, 375388 (2009).

CAS Google Scholar

Ertugrul, D. T. et al. Aspirin resistance is associated with glycemic control, the dose of aspirin, and obesity in type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 95, 28972901 (2010).

CAS Google Scholar

Cecchi, E. et al. Effect of blood hematocrit and erythrocyte deformability on adenosine 5-diphosphate platelet reactivity in patients with acute coronary syndromes on dual antiplatelet therapy. Am. J. Cardiol. 104, 764768 (2009).

CAS Google Scholar

Zaccardi, F., Pitocco, D., Willeit, P. & Laukkanen, J. A. Efficacy and safety of P2Y12 inhibitors according to diabetes, age, gender, body mass index and body weight: Systematic review and meta-analyses of randomized clinical trials. Atherosclerosis 240, 439445 (2015).

CAS Google Scholar

Ibrahim, O. et al. Evaluation of aspirin and clopidogrel resistance in patients with acute coronary syndrome by using adenosine diposphate test and aspirin test. Pak. J. Med. Sci. 29, 97102 (2013).

Google Scholar

Ojeifo, O. et al. Concomitant administration of clopidogrel with statins or calcium-channel blockers: Insights from the TRITON-TIMI 38 (trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarction 38). JACC Cardiovasc. Interv. 6, 12751281 (2013).

Google Scholar

Mitsios, J. V. et al. Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes. Circulation 109, 13351338 (2004).

CAS Google Scholar

Lau, W. C. et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction. Circulation 107, 3237 (2003).

CAS Google Scholar

Brophy, J. M., Babapulle, M. N., Costa, V. & Rinfret, S. A pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary intervention. Am. Heart J. 152, 263269 (2006).

CAS Google Scholar

Verdoia, M. et al. Impact of atorvastatin or rosuvastatin co-administration on platelet reactivity in patients treated with dual antiplatelet therapy. Atherosclerosis 243, 389394 (2015).

CAS Google Scholar

Gonzlez, A. et al. Effect of CYP2C19 polymorphisms on the platelet response to clopidogrel and influence on the effect of high versus standard dose clopidogrel in carotid artery stenting. Eur. J. Vasc. Endovasc. Surg. 51, 175186 (2016).

Google Scholar

Cunningham, F. et al. Ensembl 2019. Nucleic Acids Res. 47, 745751 (2019).

Google Scholar

Rozas, J. et al. DnaSP 6: DNA sequence polymorphism analysis of large data sets. Mol. Biol. Evol. 34, 32993302 (2017).

CAS Google Scholar

Excoffier, L., Laval, G. & Schneider, S. Arlequin (version 3.0): An integrated software package for population genetics data analysis. Evol. Bioinform. Online 1, 4750 (2007).

Google Scholar

Originally posted here:
Antiplatelet response to clopidogrel is associated with a haplotype in CYP2C19 gene in Pakistani patients | Scientific Reports - Nature.com

The Utah State Veterinarians office has identified several cases of trichomoniasis (Trich) positive bulls from a beef cattle herd.

This herd had grazed the summer of 2021 at a grazing association in southern Idaho with several other herds, including at least six herds from Utah. There are ten potentially exposed cattle herds that are awaiting test results; five herds belonging to the aforementioned grazing association and five herds that neighbor the affected properties.

Related: Livestock auction investments allowed under A-PLUS bill

It is concerning to have this large of an outbreak of Trich in Utah cattle herds, said Dr. Dean Taylor, Utah State Veterinarian. Our office is working closely with local veterinarians to conduct testing and are taking measures to stop the spread of this disease.

Trich is a venereal disease of cattle caused by a protozoa (microscopic parasite). It is spread between cattle during breeding. Cows generally abort the fetus from this breeding and then clear the infection, but bulls remain infected for life.

Related: U.S. beef imports from Brazil surge to record high in early 2022

According to information from Texas A&M University, although losses are observed in the cow,T. foetus lives on the surface of the penis and prepuce of the bull and in the reproductive tract of the cow. Trich prefers a reduced oxygen environment, and it multiplies in the small folds of tissue (crypts) on the bulls penis. Because older bulls have more numerous and deeper crypts and are more easily infected, using young bulls is part of a disease management strategy. There are no obvious signs of Trich in the male, and pregnancy loss is the only sign of the disease in the female.

Cows exposed to Trich cannot be considered safe in calf until they are at least 120 days pregnant; open cows cannot be considered free of infection until they have had at least 90 days of sexual rest and are examined and cleared by a veterinarian. Only then should they be placed back into the breeding herd. All newly acquired cows that are less than 120 days pregnant should be isolated from the breeding herd. They may be placed in the breeding herd once they are four months pregnant.

Because approximately 2 percent of infected cows will have a swollen uterus that contains pus (pyometra) and remain infective, all open cows should be examined by a veterinarian. Cows with pyometra should be sent to slaughter. There is no treatment for infected bulls; send them to slaughter.

Trich should be suspected in herds with poor conception rates and extended calving seasons. Infected herds can produce conception rates that range from slightly subnormal to 50 percent or lower, depending on the length of time the disease is in the herd and the number of animals that are infected. Conception rates in herds with controlled breeding seasons of 90 days or less will be even poorer. Shorter breeding seasons expose the problem more dramatically and can actually reduce the long-term production and economic losses caused by herd infection.

Because Trich develops gradually and is not readily apparent, it is better to prevent exposing the herd to the disease rather than trying to control or eradicate it. Trich enters a herd or ranch only via infected bulls, cows or heifers. Again, transmission is from infected bulls to cows or from infected cows to bulls. To eliminate Trich from a herd, allow infected cows to clear the infection and eliminate infected bulls altogether.

There is no treatment for Trich and this disease can be economically devastating to cattle herds because of:

Culling of positive bulls and purchase of replacement bulls

Increased abortion rate leading to a reduced calf crop

Prolonged calving season and lower calf weights at sale

Culling of open cows

Loss of genetics

Utah requires yearly testing of all bulls for Trich, with the exception of dairy cattle who are kept in confinement and bison bulls. Animals from one positive herd moved into the grazing association in 2021 without proper paperwork. It is also suspected that bulls from this herd were leased to other ranches for breeding purposes.

Source: Utah State Veterinarian's Office and Texas A&M University.which is solely responsible for the information provided and is wholly owned by the source. Informa Business Media and all itssubsidiaries are not responsible for any of the content contained in this information asset.

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Trich confirmed in Utah beef herd - Beef Magazine

Robert Russell| Special to the Times

Recently on CBS Mornings, host Tony Dokoupil, presented a story about dogs. An experiment aimed to see if dogs could distinguish between their owners native tongue and a foreign language. The experiment used brain scan technology, and sure enough, different parts of their brains activated based on whether they were familiar with the spoken language or not.

Dogs are mans best friend, or so they say. According to James Gorman, of the New York Times Magazine of October 4, 2021, all dogs are descended from the first dogs, just as all humans can trace their ancestry to the first Homo sapiens." Thus, none of us, or our dogs, have a more ancient ancestry than any other. Breeding led some dogs to be big and black, some small and white, some are strong, and some run fast.

Dogs were prized early on for their sense of smell, and with proper husbandry, they developed the genetics and physiology to make them sniffing machines.

Dogs have genes that improve olfactory ability, and more olfactory nerve cells than humans do. In addition, for centuries now, the Gentry have taken advantage of this intense sense of smell and sharp vision, to hunt prey and search for specialty items like truffles.

Today law enforcement uses dogs to locate drugs, like marijuana. Dogs have absolutely no interest in drugs, but they do enjoy games with a handler. Their training has led them to associate a toy, with the scent of various drugs. Trainers play a vigorous game of tug-of-war with dogs and a favorite towel. To begin the training, they play with a carefully washed unscented towel.

Later play involves a target substance hidden inside the towel. After playing, the dog starts to recognize that as that of his favorite toy. The trainer hides the towel, with the drugs, in typical places, and with the odor identified, he points, to get at the toy. The reward is a game of tug-of-war. Commercially the wine industry is working with dogs to identify spoiled corks and wines with various chemical compounds. They can even detect flaws in the oak barrels and corks, which lead to faults like TCA, VA, and Brett. In another use, a wine festival recently used dogs to sense attendees infected with COVID-19.

Dogs can detect many human diseases. This learning and evolving are not just improving animal skills; they can save lives.

Through human evolution, male eyes are sensitive visually to small details and moving objects, while women are more aware of color changes, according to a vision study, in The Journal of Biology and Sex Differences, referenced in this column a few years ago, noting that women see things differently. Women seem to have a superior tasting and visual skills, on average, to those of men. Since the genes of retinal cone cells are responsible for color perception, they are located on the X-chromosome, and women have two X-chromosomes-this all makes sense.

Secondly, the literature finds that in most cases females had better sensitivity, and discriminated and categorized odors better than males, as this writer can personally attest. Ancient humans lived as hunter-gatherers. Men predominately were the hunters while women were gatherers. Being a successful hunter does not require being good at smelling and tasting, but being, a successful gatherer of plant-based foods does. If you gather fruits and seeds, you need to be good at discriminating poisonous or spoiled foods, from nonpoisonous or fresh ones. Thus, men that did not hunt well, and women that did not taste and smell well, evolutionarily eliminated from the herd.

According to Mia Rozenbaum, at Understanding Animal Research, Dogs have about 220 million scent receptors humans only have 5 million. Dogs have smell receptors 10,000 times more accurate than humans, she notes their nose is powerful enough to detect substances at concentrations of one part per trillion - a single drop of liquid in 20 Olympic-size swimming pools. Dogs can detect cancer by smell, and sniff out a variety of types including skin cancer, breast cancer and bladder cancer using samples from known cancer patients, and people without cancer.

In a 2006 study, five dogs were trained to detect cancer based on breath samples. Once trained, the dogs were able to detect breast cancer with 88 percent accuracy, and lung cancer with 99 percent accuracy. They could do this regardless of the stage of the disease. More recently, a study has even shown that dogs can use their highly evolved sense of smell to pick out blood samples from people with cancer, with almost 97 percent accuracy.

Besides cancer and malaria, dogs can also detect Parkinson's disease, with a myriad of other studies now underway. Perhaps dogs may soon be the winemakers best friend, or so this writer says.

Stay healthy, and Cheers!

You can contact Robert Russell at rob@rlr-appraisals.com.

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Robert Russell: We have gone to the dogs - Shreveport Times

SAN DIEGO, Jan. 10, 2022 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (BNGO), pioneer of optical genome mapping (OGM) solutions on the Saphyr system and provider of NxClinical, the leading software solutions for visualization, interpretation and reporting of genomic data, hosted today the first of four days of 2022 Symposium, the Companys premiere event showcasing OGM research applications across key clinical areas of constitutional genetic disease, hematologic malignancies, solid tumors and OGM combined with next-generation sequencing (NGS).

Six presentations from leading researchers across North America and Europe kicked off Symposium. Todays event featured six informative speakers from leading researchers across North America and Europe. These presentations covered a wide range of constitutional genetic diseases in pre- and postnatal genetics and offered insight into potential applications in infertility and reproductive medicine. The presenters supported OGM as an effective alternative to traditional workflows such as karyotype, fluorescent in situ hybridization (FISH), chromosomal microarray (CMA) and Southern blot. Research presentations have demonstrated greater sensitivity, better resolution and faster results from OGM workflows compared to traditional methods.

Performance of OGM evaluated in pre- and postnatal samples. Both Dr. Iqbal from University of Rochester Medical Center and Dr. Shirley Heggarty compared the performance of OGM in the evaluation of pre- and postnatal samples with known chromosomal aberrations. These studies found a high concordance of OGM results compared to traditional methods. In addition, OGM was able to identify both unbalanced structural chromosome abnormalities and balanced structural variants (SVs), like translocations and inversions, that chromosomal microarray (CMA) could not.

Capabilities of OGM to measure repeat expansions were evaluated. Dr. Alexander Hoischen specifically explored the capabilities of OGM to map repeat expansions, which can be particularly challenging types of SVs, in subjects with Canvas syndrome and myotonic dystrophy types 1 and 2. The OGM workflow was able to immediately call very large insertions with greater precision than the standard cytogenetic techniques and with 100% concordance. OGM was shown to allow researchers the ability to see more of the genome, while being less time-consuming and labor-intensive than other molecular methodologies like Southern blotting, as Dr. Nikhil Sahajpal discovered. Results from his validation study were 100% concordant with traditional methods and demonstrated a streamlined laboratory workflow for different sample types.

Story continues

The role of OGM as a discovery tool in reproductive disorders including infertility. In addition to pre- and postnatal applications, two speakers, Dr. Laila El-Khattabi and Chaim Jalas, shared how the OGM workflow plays a significant role in their research in infertility and reproductive disorders. In her study, Dr. El-Khattabi used OGM to characterize apparently balanced SVs related to male infertility and identify new genes involved in reproductive disorders. Chaim Jalas shared how OGM used in preimplantation genetic diagnosis can identify structural rearrangements, including balanced translocations and inversions, in embryos prior to transfer, which they indicated could improve pregnancy and delivery rates in an IVF setting.

Among 37 posters appearing in the virtual exhibition hall the top poster per application area selected to compete for best poster of Symposium. In addition to the oral presentations, 37 posters were received and selected for presentation in the virtual exhibition hall. These posters, in the virtual exhibition hall, were voted on by attendees of Symposium and a winner was named in each of four key application areas based on total number of votes. Below are the four poster winners:

Constitutional cytogenomics: Dr. Catherine A. Brownstein, Boston Childrens Hospital

Hematologic malignancies: Dr. Jonathan L. Lhmann, Hannover Medical School

Solid tumors: Dr. Miriam Bornhorst, Childrens National Hospital

OGM + NGS: Dr. Nikhil Sahajpal, Augusta University

Sincere congratulations to our poster winners and thanks to all poster authors for sharing emerging research on OGM from their laboratories, remarked Alka Chaubey, PhD, FACMG, chief medical officer of Bionano. This event is made possible with the enthusiastic participation of the OGM community.

We are thrilled at this strong kick-off to the 2022 Symposium and we are excited about the data shared today by experts from around the world that continues to demonstrate the utility of OGM workflows in variant detection for constitutional genetic diseases, commented Erik Holmlin, PhD, president and chief executive officer of Bionano. Congratulations to the poster winners. We are impressed by all the discoveries our customers are making with OGM towards the goal of elevating human health.

Dont miss Symposium, register now! Symposium registration is open to all and there is no charge for attending this event. Register today at https://www.labroots.com/ms/virtual-event/bngo2022

About Bionano Genomics

Bionano Genomics is a provider of genome analysis solutions that can enable researchers and clinicians to reveal answers to challenging questions in biology and medicine. The Companys mission is to transform the way the world sees the genome through OGM solutions, diagnostic services and software. The Company offers OGM solutions for applications across basic, translational and clinical research. Through its Lineagen business, the Company also provides diagnostic testing for patients with clinical presentations consistent with autism spectrum disorder and other neurodevelopmental disabilities. Through its BioDiscovery business, the Company also offers an industry-leading, platform-agnostic software solution, which integrates next-generation sequencing and microarray data designed to provide analysis, visualization, interpretation and reporting of copy number variants, single-nucleotide variants and absence of heterozygosity across the genome in one consolidated view. For more information, visit http://www.bionanogenomics.com, http://www.lineagen.com or http://www.biodiscovery.com.

Forward-Looking Statements of Bionano Genomics

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as may, will, expect, plan, anticipate, estimate, intend and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the ability for additional data to support the strength of OGM workflows as compared to traditional workflows, the ability and utility of OGM to analyze genomes and reveal answers in genetic disease and cancer research in less time-consuming and less-labor intensive manners than traditional workflows, and the potential for OGM to become part of the standard of care. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the impact of the COVID-19 pandemic on our business and the global economy; general market conditions; changes in the competitive landscape, including the introduction of competitive technologies or improvements in existing technologies; failure of future study results to support those demonstrated during the presentations referenced in this press release; changes in our strategic and commercial plans; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts; the ability of medical and research institutions to obtain funding to support adoption or continued use of OGM or our technologies; and the risks and uncertainties associated with our business and financial condition in general, including the risks and uncertainties described in our filings with the Securities and Exchange Commission, including, without limitation, our Annual Report on Form 10-K for the year ended December 31, 2020 and in other filings subsequently made by us with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on managements assumptions and estimates as of such date. We do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise.

CONTACTSCompany Contact:Erik Holmlin, CEOBionano Genomics, Inc.+1 (858) 888-7610eholmlin@bionanogenomics.com

Investor Relations:Amy ConradJuniper Point+1 (858) 366-3243amy@juniper-point.com

Media Relations:Michael SullivanSeismic+1 (503) 799-7520michael@teamseismic.com

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UPDATE - Bionano Genomics Hosts Day 1 of 2022 Symposium with Six Presentations Highlighting the Superior Performance of OGM in Variant Detection for...

Introduction

Long QT syndrome (LQTS) is defined by a prolonged QT interval accompanied by morphological abnormalities in the T and/or U waves on the electrocardiograph (ECG).1 The primary clinical symptom of LQTS is syncope produced by ventricular arrhythmias.24 The clinical diagnosis of LQTS is based on a combination of the patients medical and family history, as well as the 12-lead ECG.5 According to the guidelines, LQTS diagnosis can be made in case the QTc is more than 460ms, and the patient presents some antecedents, most notably a family history of SCD and unexplained syncope.6

LQTS can be classified into two types based on its etiology: congenital LQTS (cLQTS) and acquired LQTS (aLQTS). While the former is a relatively rare genetic cardiovascular disease with a low incidence rate (1/2000-1/3000),7 the latter is frequently subsequent to electrolyte disorders, cardiomyopathy, cerebrovascular accidents, and autonomic dysfunction.

The pathogenesis of cLQTS is related to the mutation of genes encoding for ion channels, such as KCNH2,3,8 KCNQ1,2,9 TRPM4,1012 and so on, and causing ion channel dysfunction with reduced repolarization ion flow and/or increased delocalization ion flow, which in turn leads to prolonged repolarization. Among ion channel genes, mutations in KCNQ1 and KCNH2, which encode voltage-gated K+ channels involved in cardiac action potential (AP) repolarization are most common,10 followed by mutations in SCN5A which encode voltage-gated Na (1.78%), while mutations in other genes including TRPM4 are rare (below 1% of LQTS).11 Dr. Hof and colleagues were the first to hypothesize that TRPM4 mutations cause long QT syndrome, and they detected four TRPM4 variants, including c.1321 G >A, c.1495 C >T, c.1496 G >C, and c.2531 G >A, with no changes in the key LQTS genes.11

Herein, we reported a Chinese proband with cLQTS with a new mutation (NM_017636: exon4: c.434delC, p. Ala145ValfsTer133) in the TRPM4 with the hope that this report may be helpful in future genetic studies and prospective, genetically informed research.

A 75-year-old male was implanted with a permanent pacemaker 18 years ago due to a local diagnosis of bradycardia characterized by recurrent syncope since the age of 20, yet postoperative syncope continued to occur. Syncope occurred again a day before admission, and then he was taken to our hospital. Electrocardiography (ECG) at disease onset indicated sinus bradycardia, anterior wall T wave changes with visible u waves (Figure 1).

Figure 1 The admission ECG showed sinus bradycardia with QTc interval 432ms and U wave.

On admission, the following vital signs were recorded: blood pressure of 135/88mmHg, pulse rate of 59 beats per minute, the body temperature of 36.4C, and breathing rate of 18 beats per minute. Physical examination revealed no evidence of heart failure or pathological nervous system features.

After admission, repeated electrocardiograms suggested prolonged QT intervals, sinus bradycardia, and T wave changes (Figure 2). Ambulatory ECG also showed sinus bradycardia (mean heart rate 59 beats), prolonged QT interval (540ms), and torsade de pointes (Figure 3). Whats more, the electrodes on the patients pacemaker were discovered to be depleted for nearly five years. Laboratory data showed a slightly elevated level of troponin, as well as N-terminal-pro-brain natriuretic peptide, while other laboratory indexes including hepatic and renal function, electrolytes, coagulation, and inflammatory indexes were normal. We also performed a cranial MRI on this patient, and no neurological lesion was found that could cause syncope. Echocardiography indicated no abnormalities in cardiac structure, and the left ventricular ejection fraction was 61%. Moreover, selective coronary angiography was performed, indicating that the patient has no apparent pathological stenosis in the coronary arteries.

Figure 2 (AC) During the hospitalization, the ECG showed the dynamic changes of T wave; the longest QTc interval was 540ms.

Figure 3 Electrocardiogram monitoring shows torsion de pointes tachycardia.

According to the above results and the diagnostic criteria of LQTS, a highly suspected diagnosis of LQTS was finally made (Rating 6.5 out of 5).1,13,14

Then the etiology of LQTS was further explored. For no acquired LQTS associated risk factors such as electrolyte disorders, cardiomyopathy, cerebrovascular accidents, and autonomic dysfunction were found in the patients previous medical history and related examinations after admission, we are suspicious of the patients Genetics of LQTS.

After obtaining the informed consent, we conducted whole-exome sequencing (WES) on the patient and his family to confirm our diagnosis. Gene testing revealed that the patient carried a TRPM4 heterozygous shift mutation (NM_017636: exon4: c.434delC, p. Ala145ValfsTer133). Moreover, WES analysis of his family members revealed that his sister carried the same TRPM4 mutation as the patient (Figure 4), but his two brothers and son did not. Regrettably, the probands parents have all died, and hence their genes have not been obtained.

Figure 4 The results of genetic testing showed the proband and his sister carried a TRPM4 heterozygous shift mutation (NM_017636: exon4: c.434delC, p. Ala145ValfsTer133) (A), while his two brothers and son did not (B).

Because of the high risk of sudden cardiac death, we recommend implanting a cardioverter defibrillator (ICD) for the patient. Due to economic reasons, the patient refused. Due to the patients strong preference for cautious treatment, we administered Shengsong Yangxin Capsule as a placebo.

cLQTS is a rare cardiac disorder inherited in an autosomal trait, with an estimated incidence of 1:20001:3000.7 It is accepted that cLQTS is a rare ion channelopathy, and a host of genes were described to be responsible for LQTS. So far, 15 genes with more than 7000 mutations have been considered to be associated with cLQTS.15 Among the six genes encode for a pore-forming ion channel, while others encode for regulatory subunits or proteins. Mutations in KCNQ1 (3035%) and KCNH2 (2530%) encoding voltage-gated K+ channels involved in cardiac action potential (AP) repolarization are the most common among ion channel genes,10,14 followed by mutations in SCN5A, which encode voltage-gated Na+ (1.78%).11,14 In comparison, mutations in other genes, including TRPM4 are rare (below 1% of LQTS).11,12,14

As far as the pathology of LQTS, it is generally known that QT duration depends on both ventricular AP duration and AP propagation within the ventricle and ion channel dysfunction with reduced repolarization ion flow and/or increased delocalization ion flow leads to prolonged repolarization. According to a sack of animal experiments on TRPM4, TRPM4 affects cardiac electrophysiological activity through nonselective cation permeability, which leads to cLQTS.11 Unfortunately, additional research is required to decipher the biological mechanism underlying TRPM4-induced loss of function of nonselective cation permeability.

Above all, gene test counts for cLQTS. The importance of gene detection for cLQTS lies in exploring its pathogenic mechanism and its treatment, for the drugs targeted specific ion channels can be used with exerting maximal effects.

In our case, a new mutation site on TRPM4 (NM_017636: exon4: c.434delC, p. Ala145ValfsTer133) was discovered through whole-exon detection, which can provide a brand-new direction for gene screening of patients with cLQTS and further complements its diagnostic criteria. As for the detail of gene tests, we used PolyPhen2 to predict whether a new mutation is damaging to the resultant protein function. And then, according to the relevant literature, we did consider that TRPM4 is as same amino acid change as a previously established pathogenic variant regardless of nucleotide change after searching the OMIM database. But the absence of the literature for molecular pathology makes us failure to achieve the information of damaged protein. At last, combined clinical history, ECG, and the results of gene test, it was suspected that TRPM4 mutation (NM_017636: exon4: c.434delC, p. Ala145ValfsTer133) was the pathogenic variant.

In the treatment of cLQTS, beta-blockers effectively prevent cardiovascular disease and ventricular arrhythmia, and ICD implantation is regarded as the ultimate therapy.16 Because of the high risk of sudden cardiac death, we recommend implanting a cardioverter defibrillator (ICD) for the patient. Due to economic reasons, the patient refused, and we administered a placebo.

The incidence of cLQTS is very low, with the incidence of LQTS caused by TRPM4 being even lower, leading to less research on the gene TRPM4. Therefore, we reported a new mutation in TRPM4 (NM_017636: exon4: c.434delC, p. Ala145ValfsTer133) to provide more evidence for gene screening, to improve the detection rate of healthy gene carriers or patients in the early incubation stage, thereby providing further complements to the clinical data of the study about TRPM4. Notwithstanding its limitation such as lack of this patients past clinical data that can help to compare the symptom before and after the permanent pacemaker implantation, detailed information of the pedigree of this patients parents and so on, this report does hopefully serve as useful feedback information for genetic pathogenesis of cLQTS caused by TRPM4 variants.

cLQTS, congenital long QT syndrome; LQTS, long QT syndrome; ECG, electrocardiograph; AP, action potential; ICD, implanting cardioverter defibrillator; WES, whole-exome sequencing; TRPM4, transient receptor potential melastatin 4; aLQTS, acquired LQTS.

All relevant data supporting the conclusions of this article are included within the article.

The need for institutional ethics approval for this case report was waived. Written informed consent was obtained from the patient for publication of this case report and accompanying images.

The patient has provided informed consent for the publication of the case. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Dr. Rui Huang and Dr. Yinhua Luo are co-first authors for this study.

All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.

This work was supported in part by the National Natural Science Foundation of China (82160072) and the Science and Technology Support Project of Enshi Science and Technology Bureau (D20210024).

The authors declare that they have no conflicts of interest.

1. Vohra J. The long QT syndrome. Heart Lung Circ. 2007;16(Suppl 3):S5S12. doi:10.1016/j.hlc.2007.05.008

2. Beiyin G, Tingliang L, Lei Y, et al. Head-up tilt test induces T-wave alternans in long QT syndrome with KCNQ1 gene mutation: case report CARE-compliant article. Medicine. 2020;99(20):e19818.

3. Henk-Jan B, Lucia B. Orgasm induced torsades de pointes in a patient with a novel mutation with long-QT syndrome type 2: a case report. Eur Heart J Case Rep. 2018;2(2):yty062.

4. Joel G, Kinsley H, Amanda W, et al. Recurrent torsades with refractory QT prolongation in a 54-year-old man. Am J Case Rep. 2018;19:1515.

5. Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm. 2013;10(12):19321963. doi:10.1016/j.hrthm.2013.05.014

6. Priori SG, Blomstrm-Lundqvist C, Mazzanti A, et al. [2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death]. Kardiol Pol. 2015;73(10):795900. Croatian. doi:10.5603/KP.2015.0190

7. Zumhagen S, Stallmeyer B, Friedrich C, et al. Inherited long QT syndrome: clinical manifestation, genetic diagnostics, and therapy. Herzschrittmacherther Elektrophysiol. 2012;23(3):211219. doi:10.1007/s00399-012-0232-8

8. Du F, Wang G, Wang D, et al. Targeted next generation sequencing revealed a novel deletion-frameshift mutation of KCNH2 gene in a Chinese Han family with long QT syndrome: a case report and review of Chinese cases. Medicine. 2020;99(16):e19749. doi:10.1097/MD.0000000000019749

9. Motoi N, Marehiko U, Ryota E, et al. A novel KCNQ1 nonsense variant in the isoform-specific first exon causes both jervell and Lange-Nielsen syndrome 1 and long QT syndrome 1: a case report. BMC Med Genet. 2017;18(1):16.

10. Amin AS, Pinto YM, Wilde AA. Long QT syndrome: beyond the causal mutation. J Physiol. 2013;591(17):41254139. doi:10.1113/jphysiol.2013.254920

11. Hof T, Liu H, Sall L, et al. TRPM4 non-selective cation channel variants in long QT syndrome. BMC Med Genet. 2017;18(1):31. doi:10.1186/s12881-017-0397-4

12. Guinamard R, Bouvagnet P, Hof T, et al. TRPM4 in cardiac electrical activity. Cardiovasc Res. 2015;108(1):2130. doi:10.1093/cvr/cvv213

13. Hayashi K, Konno T, Fujino N, et al. Impact of updated diagnostic criteria for long QT syndrome on clinical detection of diseased patients: results from a study of patients carrying gene mutations. JACC Clin Electrophysiol. 2016;2(3):279287. doi:10.1016/j.jacep.2016.01.003

14. Neira V, Enriquez A, Simpson C, et al. Update on long QT syndrome. J Cardiovasc Electrophysiol. 2019;30(12):30683078. doi:10.1111/jce.14227

15. Tester DJ, Ackerman MJ. Genetics of long QT syndrome. Methodist Debakey Cardiovasc J. 2014;10(1):2933. doi:10.14797/mdcj-10-1-29

16. Betge S, Schulze-Bahr E, Fitzek C, et al. [Long QT syndrome causing grand mal epilepsy: case report, pedigree, therapeutic options, and review of the literature]. Nervenarzt. 2006;77(10):12101217. German. doi:10.1007/s00115-006-2118-7

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A Novel Mutation in the TRPM4 Gene | RRCC - Dove Medical Press

As with many medical issues, there can be many reasons why you have thinning hair. From stress, to hair-styling products, to your diet and your genes, its important to know the culprit behind your lacklustre locks.

But the one thing thats for sure it that youre not alone:an estimated 35 million men are suffering from hair loss worldwide.

For men, the main cause of hair loss or thinning is genetics, but not all conditions are caused by this. Other factors have been shown to disrupt growth when severe enough, such as diet, stress, hormonal imbalances and some medical treatments. These factors can affect the hair follicles causing them to go dormant.

Heres the thing: everyone loses 50-100 hair strands a day on average, but if youre experience unusual hair loss, understanding the different types and causes of this loss is important in seeking treatment from a doctor. There are many types of hair loss, with these being the most common:

Known as male-pattern baldness in men, this refers to the general thinning of hair growth. Terminal hair growth (normal hair) is converted to vellus hair (thin, short and unpigmented hairs).

Causes: Genetics, age and hormonal changes.

Sudden and unpredictable patchy hair loss. It can progress to total head hair loss (alopecia totalis) and total body loss (alopecia universalis).

Causes: An autoimmune disease causes the bodys immune system to attack hair follicles.

Large numbers of hair follicles are induced into their resting phase (telogen), resulting in increased hair shedding typically over 200 strands a day. This can be a short or long-term condition that develops two to three months after the triggering cause.

Causes: Systemic diseases, weight loss, drugs, illness, stress, iron deficiency and scalp inflammation.

Hair loss along the front and sides of the scalp caused by a persistent, prolonged or repetitive pulling force being applied to the hair.

Causes: Hair weaves, tight pony-tails and braiding techniques.

There are limits to how much you can do to reduce hair thinning and loss, but some approaches do help. Ensuring that you have a balanced diet with enough Vitamin D, Vitamin C & Iron is a great place to start but beware of going overboard with supplements as some of them such as Vitamin A could hinder growth.

Some poorly formulated shampoos can cause irritation to the scalp, so swapping to a milder alternative could help keep your scalp in good condition and a healthy scalp has been linked to hair growth. There is a compound called Minoxadil which is clinically proven to reduce certain types of hair loss. It does this by reducing the time that hair follicles are in their resting phase, telogen, and increasing the time spent growing, anagen.

Finally, it is also important to look after the hair that you are growing, including during your styling routine!

If you are experience thinning hair, there are certain hair styles that can give the appearance of a fuller head.

Consider hair styles with minimal parting, a fringe, or even try a combover thats swept to the side to disguise a receding hairline. Coloured hair sprays can also be an option to add shading to the scalp area.

During styling, its best to be gentler to your hair and scalp. While drying and styling hair, you should minimise excessive heat, and this is easiest with a controlled airflow and temperature. Be kinder to your scalp by using the Gentle air attachment (like the one on theDyson Supersonic hair dryer) as they use a gentle, cooler airflow while still drying hair fast.

Extreme heat can cause chemical changes to both the proteins and fats within your hair, this causes it to become weaker and more likely to break, which can reduce the amount of hair covering your scalp. Colouring and especially bleaching of hair can also cause weaken your hair, especially if done frequently.

The rest is here:
The Science of Thinning Hair, and The Best Ways to Style it - Men's Health Magazine Australia - Men's Health

A column about being a pregnant trans dad, and all the prejudices, healthcare challenges, personal dilemmas, and joys that come with making a family in 2021.

Merriam-Webster defines parent, primarily, as a person who is a father or mother or a person who has a child. Mother is defined as a female parent and father is a male parent. In my experience, this is exactly how most peopleparents and non-parents alikeuse these words. Thats how its meant to work: As any lexicographer will tell you, mainstream dictionaries are descriptive, not prescriptive. In the words of Simon Winchester, dictionaries tell of the language as it is, not as it should be.

We also have to father and to mother as verbs, which gets a bit more complicated. To father is synonymous with beget and sirethough Merriam-Webster notes, in a circular way, that these words are considered archaic, except in relation to domestic animals. To mother seems simpler on the face of it, maybe less overtly sexist? To mother is defined as to give birth to or to care for or protect like a mother. The first definition is the biologically essentialist one, but at least unlike with beget and sire, there are no caveats or domestic animals to be found.

Its subtle, but already we can see clear signs of a patriarchal system of society embedded in language. Is it less problematic to reduce female parenthood to biology nowadays? Surely, no feminist would argue this (except perhaps the trans-exclusionary kind). To me, and likely to any queer parent, the unqualified foregrounding of a biological role in relation to women seems like a less overt, yet much more insidious example of linguistic sexism.

Thankfully, where dictionaries might oversimplify by describing majorities first and foremost, our laws increasingly do not. With conspicuous exceptions like the UK, democratic states tend towards updating legislation to afford all parent-child relationships equal status and protection under the law, regardless of genetics or gender.

Ive written before about birth certificates, for example. In Canada, Australia, and many US states, gender-neutral birth certificates are available to all families, not just queer ones; in Canada and the US, three or more parents can be recognized on a birth certificate; and in the EU, the European Court of Human Rights recently ruled that all member states must recognize cis-queer parents on their childrens birth certificates.

The unavoidable, pragmatic, progressivehowever you see itconsequence of such laws, and, perhaps the ultimate one, is to deprivilege the traditional nuclear family structure, i.e., a married cis-hetero couple and their biological offspring. Usually, discussions on the topic center on LGBTQ+ familiesand we also tend to be most visible in campaigns to equalize outdated family law. But statistically speaking, cishet parents and their children will always make up the majority of non-traditional, non-nuclear families.

LGBTQ+ family rights, and the discussions they prompt about definitions, were never about special treatmentthey are about equality with other families. We needand need to campaign in a broad coalitionfor new systems, starting from the principle of what children, not their parents, need. This includes complete information about their origins and equal recognition of their parentage. Only by moving past our current legal and social focus on parental rightsor worse, some archaic, ideological notion of real familycan we hope to achieve true equality for all families.

How, for example, does legal motherhood and fatherhood work for the growing numbers of families, LGBTQ+ or not, created with the help of donor gametesthat is, with donated sperm or eggs?

Most of us are still very new to frank, informed conversations about using donor gametes to create family, even if weve actually done it. A few years ago, before conceiving my first child with the help of an open-ID sperm donor, I could be overheard saying, Its just like using donated blood or a kidney, right? Today, having exposed myself to the perspectives of many donor-conceived adults, innumerable donor-assisted families, and the staggering dysfunction of our birth registration system, I understand that all origin information is a persons fundamental birthright. And I believe LGBTQ+ family equality campaigners and campaigners for the rights of donor-conceived people could all benefit from closer alliance, despite being, in some ways, philosophically and linguistically at odds.

In donor-conceived online spaces, Ive noticed an almost fundamentalist approach to language. If its a coping strategyto allay donor-conceived adults completely righteous anger and sense of betrayalit makes sense. I cannot imagine many things more destabilizing than realizing youve been lied to in such a profound way by the people you trust more than anyone else, your parents. The urge to reclaim control and define things strictly according to historically-powerful systems of meaning, e.g., who is ones real or biological father/mother, seems reasonable on the face of it.

Enter the queers. Take my own situation: I am a trans man who became a dad with the help of donated sperm (literally donated, since its illegal to receive payment for gametes in the UK). With this sperm, I became pregnant and gave birth. I have always spoken openly to my kid about being donor-conceived, even before he was born. We have all the books. I will fully support my kid if he wants to contact the donor or his donor siblings in the future, or if he doesnt. Ive already looked into ways of making this possible sooner than him turning 18, which is when hell be able to access the contact details the UK regulator holds. Will I make mistakes? Of course. Am I my childs biological mother? No.

Every parent, as an integral part of becoming one, takes on a responsibility to be proactively honest with their kids about how they were created, from day zero. Also, humans are complicated and flawed, and, given its not their origins but those of their children in question, parents should not be the holders or gatekeepers of this information. A childs genetic origins, how they were conceived and birthed, and who their legal parents are can all be clearly and safely recorded for future reference by them.

But a progressive theory of identity, inclusive definitions of mother, father, parent, and my own queerness force me to stop short of referring to the person who donated the sperm that I used as my kids biological father. Yet this hesitation essentially breaks the rules of donor-conceived community etiquette, as I understand it. In short, it necessarily makes me as a parent selfish and in denial about my choices around family creation. It is seen as taking agency away, yet again, from previously deceived donor-conceived adults.

I hope those who take this position will at least hear me out. Its not the biological that gives me pause so much as the father. In every meaningful, modern sense, I am my childs father. I have this role in his life, it is legally true according to UK gender recognition law, and this is how I understand myself as a transgender man, as trans male. To me, any person who has a parental role and uses the word father for themselves is also a fatherno more, no less. Biology has nothing to do with it.

The yes, but biologically line of argument immediately veers toward the same biological essentialism used to oppress queer people, and trans people in particular, for the whole of human history. If you would not insist that trans men are biological women, and vice versa for trans womenif you recognize these as regressive, exclusionary, and dangerous opinions, as opposed to facts (not feelings!)the same must be true when we talk about family roles and relationships.

I want to clarify that Im not talking about people who meet and develop relationships with their donors. I fully accept that words like mother/father/mum/dad/parent come into play when actual human relationships form. I would never be threatened by the idea of my kid one day having two dads, or a mum and a dad if our donor is a trans woman. Thats exactly the meaning of these words that I see as, well, meaningful.

The conversation around donor siblings is a little different, largely because the idea of sibling carries infinitesimal social power relative to parent. I have seen donor-conceived adults object to the portmanteau dibling (donor sibling) as euphemistic, and yet to me, this is exactly the kind of pragmatic approach that keeps the language of family inclusive, progressive, and, ultimately, as useful as possible. Ones personal relationship to siblings resulting from donor connection is different, broadly speaking, from one's relationship to siblings who grew up as a family. Richer language helps us be clearer and more honest about that. It also de-essentializes and broadens how we understand family more generally.

My hope is that we hold firmly and compassionately to the social and political meanings of mother/father/parent and ditch the biologically essentialist ones completely. As we have begun to do with woman and man, we can let go of our need for strict categories and allow for a complexity that says: Language does not create us, we create it, and this, specifically, is no longer helpful. We no longer need both definitions, biological parent and social parent. Its too easy to subconsciously read that and as a versus, or for the question to follow: Which is more real more important? One automatically sounds like it carries more weight, right?

Is a woman less of a mother for not giving birth, or for using a donor egg? If the answer is no, and I believe wholeheartedly it is, then the best way to make this clear is to dispense with the dichotomous idea of biological mother altogetheralong with to mother meaning to give birth to. Likewise, do we think nonbinary parents are really the biological mother or father if their gametes are involved? If not, then lets not use those terms. If we continue using them for cishet parents, were still implying them for everyone. Or worse, we are drifting yet again towards a hierarchy of realness.

The social and political meanings of these words are the ones that actually matter. So lets use different words when we mean different things, and have zero tolerance for the archaic systems of oppressive power that caused us to settle for just one word, used in rank order, in the first place.

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Why We Need Gender-Inclusive Terms for 'Father' and 'Mother' - VICE

Food freedom its a complex term, with definitions ranging from ditching diet culture and restrictive diets to attaining good health and food security through growing your own foods.

Its marketed as an approach to address eating disorders for some and as a way to promote intentional weight loss for others.

However, in the health and wellness space, its an emerging, revolutionary concept that challenges societal norms of dieting and the thin ideal.

It is championed by passionate health professionals and game-changers, such as Shana Spence (@thenutritiontea). Spence is a registered dietitian who takes a non-diet, weight-inclusive approach to health.

She uses her platform to redefine what health means distinct from the diet industrys often-unattainable standards.

Another powerful and passionate food freedom champion is Dr. Kera Nyemb-Diop (@black.nutritionist), who has created a space that emphasizes body respect, eating without guilt, and reclaiming your cultural food heritage as an integral part of your healthy lifestyle.

In this article, we explore food freedom, explain what intuitive eating and mindful eating are, and discuss what roles if any they may have in the pursuit of intentional weight loss.

The food freedom framework has various definitions and applications, including but not limited to (1, 2):

In other contexts, food freedom refers to ditching dieting culture and restrictive diets by giving yourself permission to enjoy all foods in moderation (unless allergies or medical needs prevent you from eating certain foods).

In that application of food freedom, practitioners see food as more than just fuel. They seek to build a positive and judgment-free relationship with all foods, where guilt is not considered an ingredient in the eating experience.

This view of food freedom encompasses intuitive eating and mindful eating, two philosophies that cultivate self-trust around food choices and reject unnecessary restrictions.

Intuitive eating and mindful eating are often used to support recovery from eating disorders such as anorexia nervosa and bulimia nervosa, chronic mental illnesses that negatively affect nutritional status and your relationship with food (3, 4, 5).

Overall, food freedom can help people overcome diet culture or introduce flexibility for intentional weight loss.

Because the varied and overlapping marketing of the term food freedom may lead to some confusion, context matters. This article will focus on food freedom as a non-diet approach to health and nutrition.

The term food freedom has various definitions, including ditching diet culture and cultivating self-trust around food choices. The food freedom approach has been used to support both eating disorder recovery and some intentional weight loss programs.

Food freedom as a therapeutic approach for eating disorder recovery grew out of the need for non-pharmaceutical treatments that emphasize behavioral changes, such as a positive body image and healthy eating attitudes (3, 6).

A 2017 study demonstrated that dieting accompanied by body dissatisfaction and the pursuit of thinness increases the risk of developing bulimia nervosa, binge eating disorder, and purging disorder (7).

Even dieting among inherently lean individuals increases their risk of developing anorexia nervosa (7).

The multibillion-dollar diet industry promotes the thin ideal with unhealthy weight management behaviors, potentially encouraging disordered eating patterns that can contribute to the development of eating disorders (7, 8).

Theres evidence that dieting doesnt help those who are seeking long-term weight loss, either.

Weight regain within 15 years is common among chronic dieters, and approximately 33% of dieters regain more weight than they initially lost (8).

Dieting restrictions contribute to disordered eating. Food freedom, on the other hand, seeks to combat this (5).

Food freedom as a mindfulness-based practice may address disordered eating, including emotional eating and binge eating disorder. It can also help you avoid eating in response to external cues, such as the sight or smell of foods, when youre not physically hungry (6, 9).

In particular, intuitive eating is associated with improved psychological well-being and physical health and fewer dietary restrictions (5, 10).

Food freedom arose from the need for behavior-change approaches emphasizing positive body image and healthy eating attitudes instead of dieting restrictions. It can support folks in recovery from disordered eating or clinical eating disorders.

Although these three terms are often used interchangeably, you may wonder whether they are essentially the same. There are minor distinctions among their presiding principles.

For instance, mindful eating is rooted in the Buddhist practice of mindfulness and living with awareness and intention (11, 12).

Its a meditative practice that is built on the mind-body connection and fosters a state of nonjudgmental awareness that engages your senses sight, smell, taste, and feel during a meal (11, 12).

Mindful eating is the art of being present while you eat.

Similarly, intuitive eating nurtures a mind-body connection, but its distinctively rooted in a weight-inclusive approach to health and serves as the core of the Health at Every Size paradigm (10).

Intuitive eating is guided by 10 principles, including respecting your body, rejecting diet culture, making peace with food, and honoring health through gentle nutrition.

Food freedom, however, isnt so well defined. It may represent true forms of intuitive eating or mindful eating, or it may attempt to bridge gaps between intentional weight loss, caloric restriction, and increased flexibility with food.

Despite these differences, there is a common thread among the three terms: They all seek to reduce unnecessary dietary restrictions and improve your relationship with food.

They aim to remove prospects of guilt, shame, and negative emotions associated with consuming forbidden or bad foods.

The terms food freedom, intuitive eating, and mindful eating may be used interchangeably, but there are differences among these practices. However, they all seek to reduce dieting restrictions and increase flexibility.

Food freedom, when used as a non-diet approach to health, seeks to liberate you from the thin ideal and diet culture, unsafe weight loss or weight management behaviors, and yo-yo dieting.

Whether you choose to adopt a meditative approach with mindful eating or work through the 10 principles of intuitive eating, freedom from restriction and judgment is possible.

Here are some tips:

Food freedom as a non-diet approach to nutrition includes tuning in to your internal cues of fullness and hunger, removing morality from foods, and focusing on health-promoting behaviors rather than the scale.

Intentional weight loss is the active attempt to change your body weight, with the goal of lowering the number on the scale.

Although studies show that intuitive eating is associated with weight loss and a lower body mass index (BMI), at its core, intuitive eating is not a weight loss method (10).

A true intuitive eating program would not advertise weight loss as an outcome, since some people may lose weight while others may gain or maintain weight.

Intuitive eating allows your body to find its happy weight, or biologically determined set point weight.

Likewise, the fundamental principles of mindful eating are not focused on weight loss though some weight loss programs have co-opted its messages of mindfulness (11).

Other programs work to bridge the gap by focusing on health-promoting habits while instituting small calorie deficits that promote slow-paced weight loss without completely avoiding pleasurable foods that might not be nutrient-dense or low in calories.

The principles of intuitive eating and mindful eating dont focus on intentional weight loss, although weight loss, gain, or maintenance may occur when you adopt them. Instead, they focus on allowing your body to reach its happy, natural weight.

Food freedom is a highly marketed term with various definitions, ranging from overcoming diet culture and restrictive diets to engaging in food sovereignty. Therefore, context matters.

As a non-diet approach to nutrition, food freedom includes tuning in to your internal cues of fullness and hunger, decoupling foods and morality, and focusing on health-promoting behaviors not just the scale.

At their core, intuitive eating and mindful eating principles dont focus on or promote intentional weight loss. Rather, they help you discover and engage in health-promoting habits that may lead to weight loss, gain, or maintenance.

These frameworks help people foster positive relationships with foods and their bodies that are built on self-trust and self-compassion rather than on the thin ideal.

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What Is Food Freedom? Getting Started, Weight Loss, and Tips - Healthline