Archive for the ‘Hormone Physician’ Category

This article was originally published here

PLoS One. 2021 Jan 22;16(1):e0243150. doi: 10.1371/journal.pone.0243150. eCollection 2021.

ABSTRACT

Patients with autoimmune disorders (AD) have altered cancer risks compared to the general population. Systemic lupus erythematosus and multiple sclerosis lead to a heightened risk for hematological malignancies and decreased risk for breast, ovarian, and prostate malignancies. Often patients with autoimmune disease have dysregulated antiviral immune responses, including against oncogenic viruses. To uncover the relationship between viral incidence and cancer risk in the context of autoimmune disease, we extracted electronic health records (EHR) from Vanderbilt University. ICD-9/10 codes and laboratory values were collected for hematological, lung, anal-vaginal, thyroid, hepatobiliary, bladder, prostate, and breast cancers; and viruses including Epstein Barr virus (EBV), Human papilloma virus (HPV), and Hepatitis A/B/C (Hep). Only viral infections that led to a physician visit or laboratory test were entered into the EMR; therefore, only clinically relevant cases were noted and considered positive in this study. The relationship between virus infection and cancer in an SLE cohort (SLE-cases n = 2,313, and SLE-controls n = 5,702) and an MS cohort (MS-case n = 7,277, MS-control n = 7,277) was examined by multilinear logistic regression. Viral infection was strongly associated with increased risk for cancer overall. SLE and MS patients were more susceptible to all viral infections. MS patients trended toward increased risk for cancers overall, while decreased risk for hormone-based cancers in SLE patients non-significantly reduced their risk for overall cancer. Both SLE and MS patients had increased clinically relevant EBV infection, which was associated with risk for hematological cancers. Preventing viral infections by vaccination may be especially helpful in controlling risk for cancer in SLE and MS patients.

PMID:33481783 | DOI:10.1371/journal.pone.0243150

See the article here:
Contribution of viral infection to risk for cancer in systemic lupus erythematosus and multiple sclerosis - DocWire News

That in turn fends off diseases associated with extra weight like cancer, diabetes, stroke, high blood pressure and high cholesterol. Even something as simple as walking functions as medicine. Greenlee said she tries to get out every day, even in the rain.

Ive recently discovered Walking with Leslie videos on YouTube, Greenlee said. Theyre super fun, high-energy, and they can be done inside, too.

Just as important as moving is finding a moment to be still. Take a few deep slow breaths. Quiet the brain and think about the biological machine thats housing you. These types of techniques where you mindfully check in with yourself are proven to reduce stress.

We teach mind-body techniques to many of our cancer patients, Greenlee said. The important thing is to get into the parasympathetic state via mindful breathing, meditative walking or yoga.

Im cooking so much more at home and thought I was eating healthier than before COVID, but I somehow managed to gain five pounds, Judith Rixner, 64, wrote on the private Facebook group Knowledge is Power Breast Cancer Tribe. Is a sleeve of double-stuffed Oreos considered too much?

Calorie-rich, nutritionally empty processed foods may be tempting, especially during, say, a plague, but they are not our friends.

Plants are. They provide our bodies with a slew of phytonutrients and some, like brassicas, also known as cruciferous vegetables, actively fend off cancer.

Cruciferous vegetables like arugula, bok choy, broccoli, cabbage, cauliflower,kale, radishes and swiss chard have highcarotenoid content, vitamins C and K,folate, manganese and potassium, said Kate Ueland, a registered dietitian who works with Greenlee and sees cancer patients at SCCA. Theyre an excellent source of fiber and contain a group of phytonutrients known as glucosinolates, which inhibit cancer in all kinds of ways.

Greenlee pointed to a recent study in Nature emphasizing how our gut microbiome is shaped by what we eat. The findings, from the long-running PREDICT study, show that a diet rich in nutrient-dense, whole foods supported the growth of beneficial microbes that promoted good health.

What you put in your mouth matters. So, if stress-eating and/or snacking is your downfall, Greenlee said at least try to make it healthy.

Her snack of choice is kale chips, a recipe she took from Cook for Your Life, a healthy cooking site for cancer patients, survivors, caregivers and anyone else interested in learning more about what a healthy diet is, and how to achieve and maintain it. Greenlee is director of the site.

These chips are incredibly easy to make baked with a little olive oil and salt, she said. You get the crunch and the saltiness but youre eating kale.

Greenlee and Ueland work with patients at SCCA and via Cook for Your Life, recently relaunched after being acquired by the Hutch. Greenlee and her research staff use the site to test out interventions and educate people about food.

Her studies have shown people can change their eating habits for the better and for the long term if you give them the right tools and resources.

Cook for Your Life provides them: a thousand-plus recipes, 400 blog posts on nutrition and cancer, hundreds of how-to-cook videos, food myth-busting, easy substitutions and more. Tools help with online grocery shopping; special menus are available for those going through treatment. Read more about the site here.

They even teach you how to use a knife properly.

In one of our first studies, we found that if we taught people how to shop for fruits and vegetables and how to prepare them and eat them, we could change their taste preferences, she said. People were more likely to make a long-term increase in fruit and vegetable intakeand they increased their snacking of fruits of vegetables. Thats a good habit to have.

While there are thousands of food websites out there, few are science-based or bilingual, Greenlee said. Cook for Your Life highlights the nutrition research coming out of the Hutch and even offers a chance to participate in research studies.

There are a lot of recipes out there that taste great but theyre not healthy, Greenlee said. We want to provide support and we want people to feel better. This is a way for people to learn to cook at home in an easy, accessible, cost-effective, joyful and healthy way.

Even with vaccination underway, its going to be months before the country reaches herd immunity. On top of that, scientists still dont know if the COVID-19 vaccines protect against transmission.

So, continue to mask up, keep your distance and wash your hands regularly.

At this point, we do not know even with the high efficacy reported in reducing symptomatic disease whether after vaccination individuals are still infectious, Dr. Larry Corey, Hutch president and director emeritus and co-leader of the COVID-19 Prevention Networks vaccine testing program, wrote in a recent blog post.

And dont put off those cancer screenings and wellness checks that are traditionally part of the January reboot.

People should absolutely schedule their cancer screenings and wellness checks, said Dr. Rachel Issaka, a Hutch health services researcher and SCCA gastroenterologist. In the midst of a pandemic, we cannot and should not abandon chronic disease management or disease prevention.

Greenlee said its also important for our health to stay connected even when apart.

Maintaining connection with people is really important, she said. We may have to do it virtually but its still important for people to pay attention to what makes them feel good and to support the people around them.

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Shed the pandemic pounds ... and the stupor - Fred Hutch News Service

Have you been recently diagnosed with benign prostatic hyperplasia (BPH)? Are you finding it tough to achieve restful sleep with the constant trips to the bathroom, not forget the overpowering pain? Usually, men are advised to take alpha-blockers, which help to ease the symptoms of BPH temporarily. There has to be another way around this, right? This is where ProstaStream enters the picture.

Forget temporary solutions that only increase dependence with time, as a new solution is trusted to resolve BPH permanently. According to the creator of ProstaStream, Frank Neal, all it takes is a unique combination of plants and herbs that is likely to promote a peaceful mind, relaxation, and healthy prostate, urinary tract, and bladder, among others. The following review will uncover every possible layer of ProstaStream, starting with its intended purpose:

What is ProstaStream?

ProstaStream is a dietary supplement that aims to support a healthy prostate. More specifically, men who have been diagnosed with benign prostatic hyperplasia (BPH) might find comfort in this all-natural solution. BPH is a condition where men experience enlargement in the prostate gland. Though scarce information is available on the mechanisms that drive BPH, it has since been disclosed that factors including changes to the male sex hormones and age play a significant role.

Nonetheless, an enlargement in the prostate is said to put immense pressure on the bladder and urethra (i.e., the tube that allows the flow of urine). Unfortunately, this means nothing but hindrances, as the latter are the reasons why men face a wide range of symptoms, from frequent trips to the bathroom and pain while urinating to the inability to release urine from the bladder completely [1].

As explained on the official sales page, ProstaStream, which appears to have been created by Frank Neal, aims to address the root causes of an enlarged prostate. Interestingly, Frank believes that societys claims that age and changes to male sex hormones are the only known factors dont paint the complete picture. What might be the missing piece(s)? It turns out that inadequate inflammatory response and immune system are issues that trigger enlarged prostates. By reversing the additional factors, ones prostate health is trusted to get better with time.

With all of the aforementioned in mind, the only way to fully understand the ProstaStream formula is by studying the selected ingredients that make-or-break prostate health!

What ingredients are inside ProstaStream?

ProstaStream is an extensive formula seeing that it includes up to 32 ingredients per serving. To ensure that individuals are aware of what they are ingesting, weve decided to highlight a thing or two on each ingredients properties. Heres what weve managed to gather thus far (the listed concentrations are per serving):

Plant Sterols Complex (300mg)

Plant sterols are a group of substances derived from plants. They have since been widely linked to lowering cholesterol levels and may prevent cardiovascular diseases and certain cancers. The latter benefits stem from its antioxidant, anti-cancer, anti-atherogenicity, and anti-inflammatory properties [2].

Saw Palmetto Berries (200mg)

Saw palmetto berries are supposedly grown on a tree called Serenoa repens. These berries have been long used in traditional medicine to support male health. To be more specific, ingesting such berries are trusted to decrease inflammation, improve the urinary tract, and prevent hair loss while possibly tending to testosterone levels and prostate health [3].

Pygeum Africanum Bark (100mg)

Pygeum is a tree, where its bark has been widely used for medicinal purposes. At the time of writing, we discovered that this ingredient is essential in specific communities, especially when it comes to treating symptoms linked to BPH, and pains that arise due to increased inflammation, kidney-related concerns, and stomachache, among others [4].

Red Raspberry (50mg)

Red raspberries are commonly liked for their underwhelming sweetness. What many people do not know is that they have been a staple in folk medicine. Why? According to existing research, this fruit is not only rich in vitamins and minerals (i.e., B vitamins, vitamin C, zinc, magnesium, etc.) but is highly valued for its antioxidant properties [5].

Annona Muricata Leaf (50mg)

Also referred to as soursop, Annona muricata is a flowering, evergreen tree whose leaves have been used for medicinal concoctions. To date, its medicinal properties have been praised because they are known to depict diverse pharmacological aspects, namely, anti-inflammatory and anti-cancer effects [6].

Green Tea Leaf (50mg)

Green tea is generally consumed because of its rich source of a catechin called epigallocatechin-3-gallate, one of the fewest potent antioxidants known to humanity. The latter allows this ingredient to shine in different health-related areas, including brain function, fat accumulation, heart health, and cancers, prostate being one of them as well [7].

Cats Claw Bark (30mg)

Cats claw is a vine that grows in rainforests and is quite popular in South and Central America. If this ingredient is of interest, it comes in varying species, with the two most common ones being Uncaria tomentosa and Uncaria guianensis. Whats interesting about this ingredient is that it may heal numerous concerns. Some examples include inflammatory bowel disease and other inflammation-related risks, diarrhea, eczema, and Alzheimers [8].

Broccoli Leaf, Stems and Buds (20mg)

Broccoli is a type of cruciferous vegetable rich in fiber, protein, and an array of vitamins and minerals. This property is beneficial for men with BPH. Some evidence suggests that cruciferous vegetable ingestion can prolong prostate cancer growth and reduce or even prevent the condition from further advancing [9].

Tomato (10mg)

Tomatoes are by far the only fruits to house the highest concentration of an antioxidant called lycopene, which has been found to prolong BPH progression. It can also be taken to fulfill ones vitamin C, potassium, and folate requirements, to name the least. Finally, aside from its antioxidant properties, this ingredient may also increase healthy inflammation response [10].

Stinging Nettle Leaf (20mg)

Stinging nettle is an herbaceous perennial flowering plant that has since been associated with anti-inflammatory properties. If we were to consider what science suggests regarding its ingestion, some evidence indicates that it may reduce inflammation, treat BPH, and support healthy blood pressure and sugar levels [11].

Maitake, Reishi and Shitake Mushrooms and Roots (30mg)

Maitake, reishi, and shitake mushrooms are known for their increased cytokine levels, which play a significant role in boosting immune cell responses [12]. In addition to cytokines presence, an antioxidant called ergothioneine in the trio is believed to positively impact prostate health by lowering cancer risk [13].

Vitamin E (13mg)

Vitamin E is an essential nutrient that carries both anti-inflammatory and antioxidant properties. This is a unique ingredient because it is extensively found in many ecosystems that we are accustomed to (i.e., sunflower oil, almonds, pumpkin, red bell peppers, etc.). That said, this vitamins role in prostate health is supposedly tricky, as it can either better or worsen the situation [14].

Vitamin B6 (3.33mg)

Also known as pyridoxine, vitamin B6 is similar to vitamin E because it can also be consumed through food (i.e., pork, chicken, turkey, fish, peanuts, soya beans, etc.). Regarding the prostate, this vitamin might help to prevent the testosterone hormone from triggering prostate-located tumor growth. It is essential to mention that the latter is based on one study [15].

Zinc (10mg)

Zinc is an essential trace mineral that is naturally found in the foods we consume. It has been tasked with modulating the immune, kidney, stomach, colon, and metabolism functions while aiding with healing processes. A fascinating finding that has since been shared is that most people with BPH or prostate carcinoma are believed to have a zinc deficiency [16].

Selenium (140mcg)

Selenium is a type of antioxidant that tends to the body by freeing it from oxidative stress and toxins while building an extensive protective layer against future invaders. Above all, this antioxidants plasma, serum, and tissue are reasoned as being inversely related to the risk of developing prostate cancer; that is, an increase in selenium can decrease prostate cancer cells [17].

Copper (0.2mg)

Copper is an essential trace mineral and has been considered a cofactor for several enzymes. Research suggests that it may support cardiovascular health and Alzheimers disease [18]. Since copper and zinc fall within the same classification, one can expect the duo to work hand-in-hand to yield results.

ProstaStream also contains a proprietary blend (142mg), which is believed to house:

Quercetin Dihydrate

Quercetin dihydrate is an insoluble pigment classified under flavonoids, which carries a rich source of antioxidants. This, in turn, is expected to reduce inflammation, allergy symptoms, and blood pressure levels [19]. To add to that, quercetin might help prevent prostate cancer because of its anti-cancer effects [20].

Juniper Berry

Juniper berries come from an evergreen shrub called Juniperus communis. They are not only high plant compounds but have also been tied to properties such as anti-inflammation, antioxidant, antidiabetic, antibacterial, and antifungal [21].

Uva Ursi

Uva ursi, like Juniperus communis, is a shrub that grows flowers and berries, where its berries are commonly used to make medicine. Its been traditionally used to treat urinary infections, which has been proven to some extent [22].

Buchu Leaf

Buchu is a plant that is commonly found in Africa and has since been relied upon to treat the bladder, urinary tract infections, inflammation, and inflammation-induced effects on the prostate [23].

L-Glutamic Acid, L-Alanine, and L-Glycine

L-glutamic, L-alanine, and L-glycine are all types of non-essential amino acids. While this trio plays role remains unclear, ingesting them together has supposedly shown to improve prostate symptoms such as nighttime urination, prostate swelling, and frequency and discomfort of urination [24].

D-Glucarate

Also referred to as calcium D-glucarate, this respective ingredient is nothing but salt. However, its benefits are enormous. As reported, it can prevent breast, prostate, and colon cancers by removing toxins and cancer-triggering components in the body [25].

Pumpkin Seeds

Pumpkin seed or pepita is an edible seed found within pumpkins. It is not only full of essential nutrients but also antioxidants. Altogether, administering a supplement with pumpkin seeds may improve prostate, bladder, and heart health and lower blood sugar levels, among others [26].

Burdock

Burdock is a type of biennial plants whose roots, leaves, and seeds can be found in alternative medicine. The key here is its seeds, which contain a lignan compound called arctigenin. To be more specific, arctigenin has been found to prevent prostate tumor growth [27] potentially.

Cayenne Pepper

Cayenne pepper is usually sought because of its compound, capsaicin, which represents anti-inflammatory and gastroprotective properties [28]. Its anti-inflammatory properties are what needs to be highlighted here, as it may destroy prostate cancer cells. That said, more research is still required to make sound conclusions.

Goldenseal

Goldenseal or Hydrastis Canadensis is a perennial plant that grows in North America. Regarding its properties, its roots and leaves have been historically incorporated in traditional medicine to treat any health concerns involving infections and/or inflammation [29].

Gravel Root

Lastly, we have gravel root, an herbaceous perennial plant that has since been classified as belonging to the sunflower family. Its roots and bulb are mainly used for treating urinary tract problems, bladder infections, and painful urination all of which are supposedly continued despite safety issues [30].

Frequently Asked Questions (FAQs)

Who created ProstaStream?

The sales page insists that an individual named Frank Neal created the ProstaStream formula. Frank claims to have spent years of personal trials and experiments before arriving at his so-called special blend of ingredients which may help anyone support a healthy prostate. The main concern is that we know close to nothing about Frank and the manufacturing company. In fact, Frank Neal is just a pen name used to protect the authors identity.

What features does ProstaStream have?

As far as features go, it has been hinted that ProstaStream is made in the U.S., as the supplements label reads, The Food & Drug Administration has not evaluated these statements. To add to that, it is deemed natural, safe, and 100% pure as well.

What is the suggested use for ProstaStream?

ProstaStream should be treated as a dietary supplement; individuals are suggested to take two capsules daily.

Is ProstaStream generally safe to take?

ProstaStream comes across as being generally safe because it includes nothing but plants, herbs, vitamins, and minerals. Despite the latter, individuals need to further reflect on their health and the fact that certain all-natural ingredients may lack scientific evidence or may worsen ones health depending on the condition that is being targeted. Finally, anyone taking prescribed medication should consult a physician before buying ProstaStream.

Are there any side effects to taking ProstaStream?

At the time of writing, side effects have not been reported. However, ProstaStream does contain soy (i.e., plant sterols). Therefore, anyone with such allergies should refrain from taking this supplement.

How long will it take to receive ProstaStream?

On average, it can take 5 to 7 business days and up to 15 business days for orders shipped to the U.S. and international locations, respectively.

How does the ProstaStream refund process work?

A 60-day money-back guarantee protects ProstaStream. So, individuals will first need to make sure that their requests to customer service at contact@prostastream.com are made within the 60-day period that follows from the day the orders have been shipped. To ensure that everyone has a record, the date will be written on the package or sent in an email. Once approved, shipments need to be sent to the fulfillment center at 37 Inverness Drive East, Suite 100, Englewood, Colorado, 80112. It is then a matter of waiting for the shipment to be received, and the refund will then be processed.

How much does ProstaStream cost?

Each ProstaStream bottle can be purchased at the following rates:

The above prices do not reflect shipping or any customs clearance fees on international orders. At the time of writing, it was disclosed that international orders would indeed incur a shipping fee of $15.95. As for U.S. orders, these fees do not apply.

Final Verdict

Ultimately, ProstaStream is prostate support that aims to alleviate symptoms associated with benign prostatic hyperplasia. The approach was taken by the supposed Frank Neal involves clearing the body of toxins, and inflammation, both of which are steps that can naturally help to fortify the immune system. Frank insists that natural ingredients have been proven to support prostate health from different angles.

In researching the ingredients, we did notice that many of them contained vitamins, minerals, antioxidants, and anti-inflammatory properties, to name a few. We also came across a handful of studies that have either indicated that prostate issues flourish due to a deficiency in nutrients or that the presence of a particular component can prevent prostate tumor growth, reduce prostate cancer effects and possibly eliminate its known symptoms.

Having said all that, individuals need to realize that the above ingredients summary primarily focuses on its properties and not entirely on scientific evidence. As a result, we strongly recommend that everyone do their respective due diligence (i.e., in terms of health, medication interaction, medical history, etc.) before proceeding.

Another aspect worth deliberating upon is the lack of transparency. Despite the beneficial features of ProstaStream, factors such as the company, creator background, mission statement, and quality testing have all been hidden. This is undoubtedly to elicit discomfort and doubt, but luckily, customer service information is available. For people who want more details on ProstaStream, either sending an email to the team or visiting the website might be the best course of action.

See original here:
ProstaStream Review: Does It Work or Ingredient Side Effects - The Daily World

Everyone has different amounts of facial hair. The fullness, growth pattern, and texture of a person's facial hair often differs from person to person. Compared to the hair on the scalp, beard hair tends to be thicker, coarser, and curlier.

"The biggest factor for beard growth is genetics. External hormones, like testosterone or other anabolic steroids, can sometimes make people grow thicker beards than they otherwise would," says Jay Vary, MD, PhD, associate professor of dermatology at the University of Washington.

It's important to maintain a healthy lifestyle because diet, stress levels, and exercise also influence beard growth. Here's what you need to know about growing a beard.

No, not everyone can grow a beard. "Beard growth is mainly genetically predisposed," says Anthony Rossi, MD, attending dermatologist at Memorial Sloan Kettering Cancer Center. "It is under genetic and hormonal control."

Therefore, facial hair growth will vary depending on your ethnicity, says Marisa Garshick, MD, FAAD, a dermatologist at MDCS Dermatology.

In general, for those with testes, beard growth starts during puberty as testosterone levels increase. Testosterone is key for beard growth because its byproduct, dihydrotestosterone (DHT), triggers hair follicles to grow longer and thicker hairs. For transgender men, the growth of facial hair typically begins a year or more after starting their testosterone intake.

Though beard growth depends heavily on your genetics, there are some things you can do to improve the facial hair you do have and encourage it to grow.

Here are six tips from the American Academy of Dermatology Association for growing a healthy beard:

Moreover, it's important to keep the skin in the beard area as healthy as possible to avoid acne and dandruff.

It varies among different people as some grow fuller beards faster than others, says Rossi.

"Beard hair can grow at a rate of half an inch per month. It is possible to begin to grow a beard in two weeks as it is thought that facial hair grows faster than scalp hair, but it can take up to two to four months to grow a full beard," says Garshick.

According to Vary, most beards continue to grow thicker as people age into their 20s and 30s. However, if you've tried and haven't developed a thick, full beard by age 30, then it's less likely to see a big difference because that's when testosterone levels start to decrease with age, says Garshick.

You may not be able to grow a beard instantaneously, but certain practices can help stimulate hair growth, such as:

"Depending on how much it bothers you, there is such a thing as a beard transplant to actually take hairs from the back of your scalp and place them in your beard area," says Garshick.

You don't have to undergo this procedure unless you find your facial hair to be a major cosmetic concern.

One of the biggest factors for beard growth is genetics, but testosterone levels, diet, exercise, and stress levels can also influence it. Beard hair grows about half an inch per month, and it will take you about two to four months to grow a full beard from having a clean-shaven face.

Shaving generally doesn't make hair grow thicker, but you can encourage beard growth by maintaining a healthy lifestyle. Proper grooming, such as cleansing and moisturizing the beard area, is important to have a healthy-looking beard.

"If someone is trying to grow a beard, patience and genetics need to be on their side," says Vary. "Some people were born to grow thick beards and others were born to grow thinner beards or none at all."

Link:
6 dermatologist-approved tips to grow a healthy, full beard - Insider - INSIDER

Who doesnt want fuller, healthier eyelashes? Beauty bloggers and YouTubers swear that thickening and growing your eyelashes is as simple as coating them with an ingredient you probably already have stashed in your kitchen: olive oil.

But is olive oil truly an effective remedy for eyelash growth? Heres what the research and dermatologists have to say.

Eyelashes are a type of hair but instead of sprouting from your scalp, they grow out of your eyelids. Theyre actually most similar to eyebrow hair. Theyre coarser and grow slower than scalp hair, says Dendy Engelman, MD, a dermatologist at Shafer Clinic in New York.

The complete life cycle of an eyelash is 411 months. Similar to scalp hair, eyelashes thin out and go gray with age.

Olive oil is rich in fatty acids, including oleic acid, linoleic acid, and palmitic acid. Fatty acids have anti-inflammatory, antioxidant, and antimicrobial properties, and they are used worldwide for hair growth.

These fatty acids may help condition the lashes, soften skin, and encourage healthy functioning of the follicles, says Engleman. We do know that olive oil can help strengthen the hairs, she says.

A dietary deficiency in essential fatty acids has been linked to hair loss. But theres very little research showing that applying fatty acids directly to eyelash follicles helps with hair growth, notes Joshua Zeichner, MD, the director of cosmetic and clinical research at Mount Sinai Hospitals Department of Dermatology.

Most of the research that does exist is theoretical. And it looks at scalp hair, not eyelashes.

Some research suggests that oxidative stress may be linked to premature hair loss. One study found that olive oil can penetrate the skin and has an antioxidant effect.

Some research, including a 2018 study done in mice, suggests that safflower oil, which is high in linoleic acid, may also support hair growth.

A 2015 study found that applying oleuropein (the molecule that gives olives their bitter taste) to the skin of mice helped regulate their hair growth.

But its difficult to know if these findings would apply to humans. Whats more, the processing olives undergo after theyre picked greatly affects the amount of oleuropein any given product contains.

Want to try olive oil on your eyelashes? Heres how:

The typical lash growth cycle is between 30 to 60 days, at which point hair rests before falling out. That means you can expect to see results within 2 to 4 months, says Engelman.

Since the jury is out on whether olive oil is truly effective for eyelash growth, here are a few more other methods worth considering:

Im a huge supporter of science-backed skin care. Some ingredients made in a lab can deliver great results and be perfectly safe to use, says Engelman.

Latisse is the only medication approved by the U.S. Food and Drug Administration (FDA) for eyelash growth. It has been shown to increase eyelash thickness, although it may change the color of the iris and darken the skin around the lash line, says Engelman.

Always use it under the direction of your prescribing physician.

Rich in ricinoleic acid and vitamin E, castor oil helps prevent microbe growth, says Engelman. Castor oil penetrates deep into the skin to nourish the follicle, improve moisture, and promote hair growth over time.

Engelman recommends the Majestic Pure Cosmeceuticals Eyelash Serum, which uses 100 percent cold-pressed castor oil.

Research suggests this natural ingredient helps to promote eyelash growth by increasing circulation.

Engelman recommends the bbrowbar Luscious Lash Oil, which contains rosemary oil as well as castor oil, jojoba oil, and apricot kernel oil to nourish lashes.

A potent antioxidant, vitamin E neutralizes free radical damage to reduce inflammation that can interfere with the health of skin and hair follicles, says Zeichner.

Consider trying the Kate Blanc Cosmetics Vitamin E Oil.

While theres little data to support the claims that biotin treats thinning hair and eyelashes, theres little downside to taking biotin supplements, says Zeichner.

We know that biotin deficiency is associated with hair thinning, so the thought is that biotin supplements can help hair grow, he adds.

Peptides help to nourish and repair damage to hair protein, which strengthens lash hair, improving shine and elasticity, says Engelman.

She suggests the Hydropeptide Lash Longer Fuller Lusher Lash.

No matter which treatment you choose, remember to be gentle with your lashes. Dont scrub them, pick at them, or use a harsh makeup remover.

Also, keep in mind that a well-balanced diet helps keep hair in tip-top shape. Hair thrives on protein, iron, zinc, and vitamin B12, says Engelman.

No ingredient is 100 percent free of side effects for all users.

If youre using a natural product, like olive oil, there should be no side effects unless theres an allergy to an ingredient, says Engelman. If you notice redness or irritation from any skin care product, stop using it.

Theres little research to suggest that olive oil can boost eyelash growth.

However, olive oil contains several types of fatty acids that have anti-inflammatory, antioxidant, and antimicrobial properties.

Experts say olive oil may help condition the lashes and promote healthy lash follicles function. Apply once a day for several weeks to see results.

Colleen de Bellefonds is a Paris-based health and wellness journalist with over a decade of experience regularly writing and editing for publications including WhatToExpect.com, Womens Health, WebMD, Healthgrades.com, and CleanPlates.com. Find her on Twitter.

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Olive Oil for Eyelashes: How it Works, Ways to Use It, Products to Try - Healthline

MedicalResearch.com Interview with:

Kent Hoskins, MDEileen Lindsay Heidrick Professor in OncologyDivision of Hematology/OncologyUniversity of Illinois at ChicagoDirector of Cancer GeneticsCo-Leader, Breast Cancer Research GroupUniversity of Illinois Cancer Center

MedicalResearch.com: What is the background for this study?

Response: The racial disparity in breast cancer mortality emerged in the US in the late 1980s in the wake of widespread implementation of mammography screening and the development of successful systemic adjuvant therapies for early breast cancer. Unfortunately, more than three decades later, Black women in the US still have a 40% higher mortality rate from breast cancer compared with non-Hispanic White women despite similar disease incidence. Health disparities research has primarily focused on the fact that Black women have a higher incidence of the aggressive triple-negative subtype, and that they are more likely to present with more advanced stages of disease. As important as those factors are, in recent years our group and others reported that Black women with hormone receptor-positive breast cancer have worse survival than non-Hispanic white women even after adjustment for stage at diagnosis and treatment. Since nearly 2/3 of breast cancers in Black women are hormone receptor-positive, this is a significant contributor to the overall mortality disparity. Importantly, these studies also suggested that Black women disproportionately develop biologically aggressive forms of hormone-dependent breast cancer, which is typically considered a more favorable disease subtype.

Using data on more than 70,000 patients from the SEER registry that is linked to data from Genomic Health Laboratory, which provides the Oncotype DX recurrence score (the most commonly ordered prognostic/predictive multi-gene expression assay for early breast cancer), we set out to address three questions:

1) is there evidence of disproportionately aggressive tumor biology among Black women with hormone receptor (HR)-positive breast cancer, as reflected in the Oncotype DX recurrence score?

2) Is there a racial survival disparity even among patients with early stage, axillary node-negative tumors with comparable recurrence scores on the Oncotype assay? and

3) Is there is a difference in the prognostic accuracy of the Oncotype assay between Black and non-Hispanic white patients, since there was limited representation of Black women in the development and validation of the Oncotype assay and other prognostic/predictive assays?

MedicalResearch.com: What are the main findings?

Response: We found that Black women with axillary node-negative tumors were 30% more likely to have a high risk recurrence score. When we adjusted for age and tumor size, Black women were still 20% more likely to have a tumor with a high risk recurrence score.

We also found that Black women with axillary node-negative tumors had a 66% higher rate of breast cancer death overall. Within each recurrence score risk category, Black women were 1.5-2.5 times more likely to die from breast cancer compared with non-Hispanic white women, even after adjusting for age, tumor size, and treatment (initiation of surgery, radiation, and chemotherapy). Importantly, the SEER dataset does not collect information on use of endocrine therapies, which is an important limitation of this study.

Finally, we found that the Oncotype assay has lower prognostic accuracy in Black compared with non-Hispanic white women. This suggests that genomic assays, like the Oncotype assay, that are used to make decisions on the use of chemotherapy in early breast cancer need to be re-calibrated for women from racial/ethnic minority groups.

MedicalResearch.com: What should readers take away from your report?

Response: I think the main message here is that even among women with presumably favorable prognosis breast tumors (HR-positive, axillary node-negative), Black women die from their cancer at a significantly higher rate than women from most other racial/ethnic groups, even after controlling for treatment and known prognostic variables (including the Oncotype recurrence score). Tumor biology plays an important role, but it is probably not the only factor underlying this disparity. Social determinants of health are almost certainly a major driver of this disparity as well, and the finding of a biologic component cannot allow us to take our eye off the critical role of social factors that are at the root of health disparities.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: The most immediately impactful research would be studies that formally test the calibration of multigene expression assays that are used to make chemotherapy decisions for early breast cancer in racial/ethnic minority groups. These assays may require re-calibration in order to provide the most accurate prognostic and predictive information for patients from minority groups. Over the longer term, it will be important to determine the underlying drivers of disproportionately aggressive tumor biology, and to conduct studies that examine the intersection between social determinants of health (SDH) and tumor biology. What are the non-biologic contributions of SDH to worse outcomes in Black women with early stage, HR-positive breast cancer, and do social determinants influence tumor biology? Ultimately this research will inform precision medicine approaches to therapy that target molecular drivers of disproportionately aggressive tumor biology in Black women with hormone-dependent breast cancer.

MedicalResearch.com: Is there anything else you would like to add?

Response: I think this study highlights once again the far-reaching deleterious effects of biomedical research that does not have adequate representation of individuals from racial/ethnic minority groups in the formative stages of research, whether that research is to develop innovative diagnostic and prognostic tests or new therapeutic approaches.

I have received research support from Pfizer, Inc., which was not involved in the conception, design, data acquisition or analysis for this study and did not provide any funding for this study.

Citation:

Hoskins KF, Danciu OC, Ko NY, Calip GS. Association of Race/Ethnicity and the 21-Gene Recurrence Score With Breast CancerSpecific Mortality Among US Women.JAMA Oncol.Published online January 21, 2021. doi:10.1001/jamaoncol.2020.7320

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Breast Cancer: Genome Assays May Need Recalibration for Racial and Ethnic Groups - MedicalResearch.com

FLINT, Mich., Jan. 8, 2021 /PRNewswire/ --Forum Health, LLC, a nationwide provider of personalized functional and integrative medicine, has acquired Healing Arts Center, a functional medicine practice based in Valparaiso, Indiana.

This multidisciplinary practice is comprised of an experienced team of providers including a physician, board-certified traditional Naturopath, licensed acupuncturist, nutritionist, chiropractor, and massage therapist. The clinic delivers a broad scope of complementary health services designed to encourage well-being and health in a caring and compassionate environment.

"We are thrilled to welcome the Healing Arts Center team to the Forum Health family. The clinic's patient-focused mission for helping people overcome chronic conditions and lead healthier lives, directly aligns with our philosophy. Healing Arts Center is dedicated to providing the highest level of care possible using Forum Health's holistic and personalized medicine approach," said Forum Health CEO, Phil Hagerman.

With a focus on complementing traditional medicine with alternative health treatments, Healing Arts Center offers a wide variety of services including IV, Chelation and Ozone therapies, acupuncture, reflexology, reiki, craniosacral therapy, massage therapy, hormone testing, allergy elimination, hypnotherapy, and more. They specialize in treating Lyme disease, Parkinson's, dementia, ADD, autism, anxiety, depression, weight loss, allergies, and other specific conditions.

"My team and I are excited to join the growing network of nationwide providers at Forum Health and to offer even more to our existing patients and community," said Dr. Kimberling, founder and lead practitioner of Healing Arts Center.

About Forum Health

Forum Health, LLC is a nationwide provider of personalized healthcare. Steeped in the powerful principles of functional and integrative medicine, Forum Health providers take a root-cause approach to care. They listen and dig deep exploring lifestyle, environment, and genetics to help each patient achieve their ultimate health goals. Members have access to advanced medical treatments and technology, with care plans informed by data analytics and collaborative relationships. To learn more, visitforumhealth.com.

To learn more, visit our practice location page.

SOURCE Forum Health, LLC

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Forum Health, LLC adds Healing Arts Center to its growing community of Integrative and Functional Medicine practitioners - PRNewswire

Big brows are all the rage on runways. But sparse or thinning eyebrows arent uncommon everywhere else. A 2012 research review showed that there are many possible causes of thinning or sparse eyebrows, including:

Lets cover some strategies for filling in and treating eyebrows that have lost some of their fullness.

The easiest way to treat thin eyebrows is to use makeup to make them look thicker and fuller. There are several types of makeup products that you can use to do this, including:

You may want to experiment with a few products, mixing and matching to find the beauty routine that gives you the eyebrow look you want.

To try filling in your eyebrows to make them look fuller, start with these steps:

If you want a remedy thats more permanent than makeup, you can consider these other techniques and treatments for filling in your eyebrows.

You can use semipermanent or permanent hair dye to add a darker pigment to your eyebrows. This can give the illusion of brows that are thicker and fuller.

You can DIY this treatment yourself with drugstore hair dye or go to an esthetician.

A 2017 research review showed that hair loss has been linked to some vitamin deficiencies, including vitamin D and iron deficiencies.

So, it makes sense to think that taking nutritional supplements for vitamin D and iron may help regrow your hair, including at your eyebrows.

Additionally, the same research review above showed that if you dont have a nutritional deficiency, dietary supplements likely wont be effective.

Anecdotally, some essential oils are said to promote hair growth on your head and at your eyebrows.

Be sure to always dilute them with a carrier oil, and do not use oils too close to your eye and on your eyelid. Castor oil and peppermint oil are two anecdotal favorites for hair growth.

Microblading is a cosmetic procedure performed by a licensed provider. The goal of microblading is to make your brows look full and even.

Microblading (and its cousin procedure, nanoblading) does this by making tiny, feather-like strokes that mimic real hair and filling these strokes with a semipermanent pigment.

The results of microblading last 8 to 30 months, after which you will have to get a touch-up if you like the result.

Similar to microblading, microshading is a procedure also performed by a licensed provider.

Unlike microblading, microshading mimics the appearance of a powdered makeup application (in other words, it looks like makeup and not like real eyebrows). Microshading lasts 3 to 6 months.

Semipermanant eyebrow tattoos (such as henna) and regular, permanent tattoos have been around for many years. They often do not look as realistic as microblading.

According to a 2016 study, bimatoprost (Latisse) has not yet been approved by the FDA for the use of eyebrow restoration and would be considered off-label use. The dosage is a topical application to your eyebrows once or twice daily.

This FDA-approved medication for eyelash growth stimulation is by prescription only, and it may take several months to see full results.

Minoxidil (Rogaine) is available as both an over-the-counter and prescription-strength medication. It can be used as a topical foam, a concentrated solution, or be given orally.

In a small 2014 study, 39 participants were asked to use a lotion containing minoxidil on one side of their faces, and a placebo product on the other side in an attempt to treat eyebrow thinning.

The study found that the minoxodil side saw significantly better results than the placebo.

You can talk with a dermatologist or cosmetic surgeon about hair grafts that target your eyebrows. These types of grafts use your existing hair follicles to fill in thin spots and encourage regrowth.

These eyebrow transplant procedures can be quite expensive, require a few weeks of recovery, and there is a risk of serious side effects and infection.

Sparse eyebrows can have several causes.

Overplucking or tweezing your eyebrows can damage your hair follicles and lead to poor hair regrowth. Other causes of sparse eyebrows include:

Hair loss from your eyebrows can be frustrating, but there are lots of available treatments. You can also look into cosmetic procedures and even hair grafts to make your brows look bigger.

If youre concerned about hair loss or cant figure out whats causing it, talk with a doctor.

Continue reading here:
Sparse Eyebrows Treatment, Home Remedies, and Precautions - Healthline

A good nights sleep can do wonders for anyone.

However, this is especially true for aging adults, according to Brandy Delp, executive director of Windsor Heights Assisted Living and Memory Care in Beachwood, and Dr. Mark Levy, owner and founder of Sleep Better Columbus in Columbus.

Hormones tend to change as we get older, which affects all kinds of things like sleep cycles and bathroom needs, Levy said. The hormone changes make you have to use the bathroom more and those needs cause you to have to get up, which disturbs sleep and ultimately wakes you up.

Delp said, As we age, changes in our hormone production occurs such as a decrease in melatonin, which helps promote sleep. Older adults have a harder time falling asleep, have frequent nighttime awakenings and increased difficulty returning to sleep once awakened.

Delp added that age-related sleep patterns also involve earlier bedtimes and early morning rising times, and frequent naps during the daytime hours.

Another change seniors may observe in their sleep patterns stems from breathing issues and changes, Levy said.

As you get older, the tissues in the back of your throat get a little slack and not as firm, he explained. That leads to snoring and sleep apnea. All of that snoring and related events can cause you to stop breathing, which are micro-arousals, and bring you up out of deep sleep.

Sleeping well allows one to start the day refreshed and rested. But why does having enough sleep make people feel so good?

Delp said it is closely related to the processes bodies go through while were at rest, which can be especially important as we age.

Several processes occur during sleeping, such as acceleration of protein synthesis and tissue repair, increased production of growth hormone, as well as cognitive function and memory formation, she said. Sleep plays a vital role in brain function and the immune system along with several other bodily processes.

Levy said, Physically, you need to heal. But mentally, sleep allows you to regroup and process the days events. Your brain needs that time.

For aging adults, lack of sleep can lead to serious health conditions like cognitive issues, Delp noted. Fatigued people also put themselves at risk for falls, as well as mood issues like anxiety, depression and irritability. Levy said lack of sleep can lead to brain fog, which can cause confusion in daily tasks for seniors.

At Sleep Columbus, Levy said patients seek oral appliance solutions for sleep apnea and snoring. Though they cant dispense CPAP machines, they also offer sleep testing out of the office to determine if a patient has sleep apnea.

We do a lot of hand holding and guiding, and were the connector between the things they do to make it better, he said. Were a lot more accessible and basically are the sleep tour guide.

As for Windsor Heights, staff works daily to ensure an optimal nights sleep for residents, according to Delp.

We keep routines for our residents, offer bedtime snacks, close the curtains in the evening, increase physical activity during the daytime and plan quiet activities in the evening, Delp said.

She had other suggestions for seniors struggling with sleep issues.

Exercise regularly, avoid stimulants three to four hours before bedtime such as coffee, chocolate, cigarettes and soda, and dont use electronic devices at least an hour before bed, Delp said.

Those experiencing sleep issues should also consult a physician.

First thing to do is have a conversation with their primary care doctor, and if they suspect sleep apnea, they can call someone like us, Levy said. Recommendation is always the best place to start the process of getting help for any health issue.

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Heres an idea for experiencing restful days sleep on it - Cleveland Jewish News

There's a lot to love about caffeine. First, because it's found in plants, it can actually be said to be all-natural, and those plants, including the ones used to make coffee, tea, and cocoa, are rich in sources of antioxidants and phytonutrients. Caffeine, itself, is a phytonutrient that can help reduce your risk of Parkinson's, dementia, and certain oral cancers, according to the University of Michigan Health Service.

One of caffeine's immediate physiological effects is to speed up your central nervous system, which can help you feel alert and focused. Another is that it increases levels of dopaminewhich is one of those "feel-good" chemicals your body produces that improves your mood.

Consuming moderate amounts of caffeine (up to 400 milligrams per day, or the equivalent of four cups of coffee) has never been scientifically linked to long-term harm in healthy adults. However, that's not to say it doesn't have side effects.

For example, to the extent it can improve your mood, it can also be addictive. And while it can keep you focused, it can also leave you feeling overstimulated, according to registered dietitian Amy Goodson. Read on to learn more about the side effects of drinking caffeine, according to science. And don't forget to check out the 7 Healthiest Foods to Eat Right Now.

"Because caffeine is a stimulant, it increases your heart rate while it's in your system," says general practice physician, Leann Poston, MD. "At the same time, it causes the blood vessels to narrow, which increases the pressure the heart must exert to circulate blood." This sets you up for a temporary spike in blood pressure.

That said, high blood pressure is a serious condition that, over time, can put you at increased risk for heart disease, stroke, and kidney failure, among others. It's also associated with the most serious and even life-threatening presentation of the COVID-19 infection.

The good news is that the rise in blood pressure attributable to consuming caffeine is temporary, according to Sheldon G. Sheps, M.D., via Mayo Clinic. However, if you've been diagnosed with high blood pressure, it's not a bad idea to ask your doctor if you need to limit your intake of caffeinated beverages.

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Most people associate headaches with caffeine-withdrawal. However, a 2004 study published in the scientific journal Neurology found that among people who suffer from chronic daily headaches, a condition in which headaches are suffered at least 15 times per month, a significant percentage had been heavy caffeine drinkers prior to the onset of their chronic daily headaches.

Similarly, among migraine sufferers, caffeine overuse has been associated with an increase in migraine frequency. If you get frequent headaches, you might want to consider cutting some of these headache-triggering foods out of your diet.

"If you are already stressed or anxious, caffeine can make it worse," according to registered dietitian Elisa Bremner. In fact, as little as 100 milligrams of caffeinethe equivalent of one cup of coffeemay exacerbate pre-existing feelings of stress and anxiety. The scientific community offers several reasons for this. One is that the natural effects of caffeine as a stimulant cause a number of physical symptoms that we tend to associate with anxiety, including increased heart and breathing rates. Our bodies may experience those symptoms as anxiety.

In addition, caffeine stimulates the release of adrenaline, Dr. Poston tells Eat This, Not That! Adrenaline is a hormone that prepares us for "fight or flight" when we're faced with stressors. It does so by increasing alertness and raising heart rate, respiration, and blood flow. And because caffeine competes with a chemical called adenosine, which leads to feelings of fatigue and relaxation, the whole combination of all of these effects can lead to distinct feelings of nervousness, jitteriness, and anxiety.

Nevertheless, here is why you might want to consider drinking coffee before taking a nap.

Caffeine consumption has been linked to an increased risk of miscarriage, according to this paper published in 2020 in the scientific journal BMJ. The paper, which consisted of a meta-analysis of 48 existing studies addressing the link between caffeine consumption and negative pregnancy outcomes such as miscarriage, found that drinking coffee while pregnant is, in fact, associated with pregnancy loss.

The reason, according to OB/GYN, Jodie Horton, MD, may be linked to the fact that caffeine narrows blood vessels, which can diminish the transfer of nutrients to the fetus. It's worth pointing out, however, that these findings are at odds with the current recommendations from the American College of Obstetrics and Gynecology, which state that "moderate consumption" of caffeine does not present a miscarriage risk, according to OB/GYN Brittany Noel Robles, MD. Nevertheless, Dr. Robles recommends keeping caffeine to a minimum during pregnancy. (Related: Don't miss these 8 pregnancy myths, busted.)

Caffeine's stimulant effect can help ensure that you'll keep your digestive system "moving."However, for some people, caffeine is too stimulating, which is to say, it can have a laxative effect. In other words, caffeine can cause loose bowels and evendiarrhea. Diarrhea is a major symptom of irritable bowel syndrome, according to Johns Hopkins Medicine's Health Blog.

If you're running to the bathroom every time you have caffeine, it may be worth talking to your doctor about whether you might be suffering from irritable bowel syndrome. Whether or not you are diagnosed, the discussion could lead to you deciding to limit your caffeine intake until you find a level at which consumption does not equal digestive distress.

For more on caffeine, here are 11 surprising ways that drinking tea can heal you.

Read more:
Side Effects of Drinking Caffeine, According to Science | Eat This Not That - Eat This, Not That

publication date: Jan. 8, 2021

FDA has approved Tagrisso (osimertinib) for adjuvant therapy after tumor resection in patients with non-small cell lung cancer whose tumors have epidermal growth factor receptor exon 19 deletions or exon 21 L858R mutations, as detected by an FDA-approved test.

Tagrisso is sponsored by AstraZeneca Pharmaceuticals LP.

Efficacy was demonstrated in a randomized, double-blind, placebo-controlled trial (ADAURA, NCT02511106) in patients with EGFR exon 19 deletions or exon 21 L858R mutation-positive NSCLC who had complete tumor resection, with or without prior adjuvant chemotherapy.

Eligible patients with resectable tumors (stage IB IIIA) were required to have predominantly non-squamous histology and EGFR exon 19 deletions or exon 21 L858R mutations identified prospectively from tumor tissue in a central laboratory by the cobas EGFR Mutation Test. A total of 682 patients were randomized (1:1) to receive osimertinib 80 mg orally once daily or placebo following recovery from surgery and standard adjuvant chemotherapy, if given.

The major efficacy outcome measure was disease-free survival in patients with stage II IIIA NSCLC determined by investigator assessment. Median DFS was not reached (38.8, NE) in patients on the osimertinib arm compared with 19.6 months (16.6, 24.5) on the placebo arm (HR 0.17 95% CI: 0.12, 0.23; <0.0001). DFS in the overall study population was a secondary efficacy outcome measure; the median was not reached (NE, NE) in patients on the osimertinib arm compared with 27.5 months (22, 36) on the placebo arm (HR 0.20 95% CI: 0.15, 0.27; <0.0001).

Iclusig receives FDA sNDA approval for adult patients with resistant or intolerant chronic-phase CML

FDA has approved the supplemental New Drug Application for Iclusig (ponatinib) for adult patients with chronic-phase chronic myeloid leukemia with resistance or intolerance to at least two prior kinase inhibitors.

Iclusig is sponsored by Takeda Pharmaceutical Company Ltd.

The updated label includes an optimized, response-based ICLUSIG dosing regimen in CP-CML with a daily starting dose of 45 mg and, upon achieving 1% BCR-ABL1IS, dose reduction to 15 mg. This dosing regimen aims to maximize benefit-risk by providing efficacy and decreasing the risk of adverse events, including arterial occlusive events.

The sNDA approval is based on data from the phase II OPTIC (Optimizing Ponatinib Treatment In CML) trial, as well as five-year data from the phase II PACE (Ponatinib Ph+ ALL and CML Evaluation) trial.

The OPTIC trial included patients with CP-CML whose disease was highly-resistant to their immediate prior TKI, the majority of whom (65%) did not achieve a response greater than complete hematological response on immediate prior therapy.

At 12 months, 42% of 88 patients utilizing the newly approved response-based dosing regimen (45 mg to 15 mg) achieved 1% BCR-ABL1IS, the primary endpoint of OPTIC, and at a median follow up time of 28.5 months, 73% of these patients maintained their response. In these patients, 13% experienced an AOE of any Grade, 7% experienced Grade 3 or higher. Risk factors such as uncontrolled hypertension or diabetes should be managed, and caution should be exercised when treating patients with active or substantial history of clinically significant, uncontrolled cardiovascular disease.

Xpovio receives FDA approval for refractory or relapsed multiple myeloma

FDA has approved Xpovio (selinexor) in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.

Xpovio is sponsored by Karyopharm Therapeutics Inc.

FDA granted Xpovio accelerated approval in 2019 in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma who received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody.

Efficacy of Xpovio in combination with bortezomib and dexamethasone was evaluated in the BOSTON Trial (KCP-330-023, NCT03110562), a randomized (1:1) open-label, multicenter, active comparator-controlled trial in patients with RRMM who had previously received at least one and at most three prior therapies.

Patients received once-weekly selinexor orally in combination with once-weekly bortezomib subcutaneous and low-dose dexamethasone twice-weekly orally compared to the standard twice-weekly bortezomib plus low-dose dexamethasone.

The main efficacy outcome measure was progression free survival assessed by an independent review committee using International Myeloma Working Group response criteria. The estimated median PFS was 13.9 months (95% CI: 11.7, Not Estimable) for the SVd arm and 9.5 months (95% CI: 7.6, 10.8) for the Vd arm (estimated hazard ratio 0.70; 95% CI: 0.53, 0.93).

Orgovyx receives FDA approval for advanced prostate cancer

FDA has approved the first oral gonadotropin-releasing hormone receptor antagonist, Orgovyx (relugolix) for adult patients with advanced prostate cancer.

Orgovyx is sponsored by Myovant Sciences inc.

Efficacy was evaluated in HERO (NCT03085095), a randomized, open label trial in men requiring at least one year of androgen deprivation therapy with either prostate cancer recurrence following radiation or surgery or newly diagnosed castration-sensitive advanced prostate cancer. Patients (N=934) were randomized (2:1) to receive relugolix 360 mg oral loading dose on the first day, followed by daily oral doses of 120 mg, or leuprolide acetate 22.5 mg injection subcutaneously every 3 months for 48 weeks.

The main efficacy outcome measure was medical castration rate defined as achieving and maintaining serum testosterone suppression to castrate levels (< 50 ng/dL) by day 29 through 48 weeks of treatment. The medical castration rate was 96.7% (95% CI: 94.9%, 97.9%) in the relugolix arm.

Margenza receives FDA approval for metastatic HER2-positive breast cancer

FDA has approved Margenza (margetuximab-cmkb) in combination with chemotherapy, for the treatment of adult patients with metastatic HER2-positive breast cancer who have received two or more prior anti-HER2 regimens, at least one of which was for metastatic disease.

Margenza is sponsored by MacroGenics.

Efficacy was evaluated in SOPHIA (NCT02492711), a randomized, multicenter, open-label trial of 536 patients with IHC 3+ or ISH-amplified HER2+ metastatic breast cancer who had received prior treatment with other anti-HER2 therapies. Patients were randomized (1:1) to margetuximab plus chemotherapy or trastuzumab plus chemotherapy. Randomization was stratified by chemotherapy choice (capecitabine, eribulin, gemcitabine, or vinorelbine), number of lines of therapy in the metastatic setting ( 2, > 2), and number of metastatic sites ( 2, > 2).

The main efficacy outcome measures were progression-free survival by blinded independent central review and overall survival. Additional efficacy outcome measures were objective response rate and duration of response assessed by BICR.

Median PFS in the margetuximab arm was 5.8 months (95% CI: 5.5, 7.0) compared with 4.9 months (95% CI: 4.2, 5.6) in the control arm (HR 0.76; 95% CI: 0.59, 0.98; p=0.033). Confirmed ORR was 22% (95% CI: 17, 27) with a median DOR of 6.1 months (95% CI: 4.1, 9.1) in the margetuximab arm compared to an ORR of 16% (95% CI: 12, 20) and median DOR of 6.0 months (95%CI: 4.0, 6.9) in the control arm.

CPI-613 receives FDA Fast Track Designation for treatment of AML

FDA has granted Fast Track designation to CPI-613 (devimistat) for the treatment of acute myeloid leukemia.

CPI-613 is sponsored by Rafael Pharmaceuticals Inc.

Rafael Pharmaceuticals received Fast Track designation for devimistat for the treatment of metastatic pancreatic cancer in November 2020. The company also received Orphan Drug Designation for the treatment of soft tissue sarcoma for devimistat, and the initiation of a phase II clinical trial of devimistat in combination with hydroxychloroquine in patients with clear cell sarcoma of soft tissue.

EU CHMP issues positive opinion for Keytruda as first-line treatment in adult patients in colorectal cancer indication

The Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion recommending approval of Keytruda, Mercks anti-PD-1 therapy, as monotherapy for the first-line treatment of adult patients with metastatic microsatellite instability-high or mismatch repair deficient colorectal cancer.

Keytruda is sponsored by Merck.

This recommendation is based on results from the pivotal phase III KEYNOTE-177 trial, in which Keytruda, as a monotherapy, demonstrated a significant improvement in progression-free survival compared to chemotherapy (investigators choice: mFOLFOX6 with or without bevacizumab or cetuximab; or FOLFIRI with or without bevacizumab or cetuximab), a current standard of care.

Data from KEYNOTE-177 were presented at the virtual scientific program of the 2020 American Society of Clinical Oncology Annual Meeting and were published in The New England Journal of Medicine. The CHMPs recommendation will now be reviewed by the European Commission for marketing authorization in the European Union, and a final decision is expected in the first quarter of 2021.Servier and Celsius Therapeutics collaborate on colorectal cancer research

Servier and Celsius Therapeutics have formed a strategic collaboration focused on the identification and validation of novel colorectal cancer drug targets.

Through this collaboration, we will leverage Celsius single-cell genomics platform, machine learning capabilities, and target validation expertise to refine our understanding of the different subtypes of CRC and discover new drug targets with the goal of developing novel precision therapies for specific patient subsets, Hugues Dolgos, global head of oncology research and development at Servier, said in a statement. Servier will discover and develop candidate drugs leveraging our end-to-end small molecule and large molecule capabilities.

Under the terms of collaboration, Celsius will analyze hundreds of samples from defined CRC patient populations using its proprietary single-cell genomics platform and will work to identify and validate new drug targets during the three-year research period. Servier will receive an exclusive option to research, develop, and commercialize products directed to up to three of the targets.

Celsius would receive an upfront payment and research funding, and would be eligible to receive over $700 million in potential discovery, development, and commercialization milestone payments, along with tiered royalties.

Bayer and Veracyte collaborate on precision oncology in thyroid cancer

Bayer and Veracyte have entered a collaboration to advance the Precision Oncology Patient Identification Program in thyroid cancer.

Through the program, Bayer will offer testing with Veracytes Afirma Xpression Atlas to identify underlying genomic drivers, including NTRK gene fusions, within patients tumors. The program will focus on patients with advanced or metastatic thyroid cancer that is radioactive iodine refractory who may potentially benefit from biomarker-driven therapies.

Patients whose thyroid cancer contains actionable alterations and no longer responds to traditional radioactive iodine therapy now have targeted treatment options available to them. Our goal is to identify such patients so physicians can make more informed treatment decisions for their patients, Bhavesh Ashar, senior vice president and head of U.S. Oncology at Bayer, said in a statement. With its comprehensive ability to identify broad genomic alterations through its Afirma XA test and its widespread reach among physicians who diagnose thyroid cancer, Veracyte is an ideal collaborator for this program.

The Afirma XA uses RNA whole-transcriptome sequencing to identify 905 DNA variants and 235 RNA fusions in 593 genes, including novel NTRK fusions, on fine needle aspirates taken from thyroid nodules or lymph nodes.

Through this collaboration, Bayer will provide Afirma XA testing at no cost to all eligible patients when ordered by the physician, regardless of the final results and treatment decision. Additionally, physicians of patients found to harbor NTRK gene fusions as an underlying driver in their thyroid cancer will be alerted of the results. The companies anticipate the program to launch in the first quarter of next year.

Servier to acquire Agios Pharmaceuticals oncology business

Servier has entered into an agreement for the acquisition of Agios Pharmaceuticals oncology business including its commercial, clinical and research-stage oncology portfolio for up to $2 billion, including an upfront payment of $1.8 Billion and a potential $200 million in regulatory milestone, plus royalties.

The transaction has been approved by both companies respective boards of directors. Subject to receipt of regulatory clearances and approval by Agios shareholders, the acquisition is expected to close in Q2 2021.

Servier has made oncology one of its strategic priorities, allocating 50% of its overall research and development budget to this therapeutic area. The acquisition will reinforce Serviers presence in the U.S., where the group has been operating since 2018.

The transaction includes the transfer of Agios oncology portfolio and associated employees, including its marketed medicine Tibsovo, which is approved in the U.S. as monotherapy for the treatment of adults with IDH1-mutant relapsed or refractory acute myeloid leukemia and for adults with newly diagnosed IDH1-mutant AML who are 75 years old or who have comorbidities that preclude the use of intensive induction chemotherapy.

Tibsovo is also under investigation in two phase III combination trials in newly diagnosed AML, and as a potential treatment for previously treated IDH1-mutant cholangiocarcinoma and IDH1-mutant myelodysplastic syndrome. Servier will also acquire Agios co-commercialization responsibilities for Bristol Myers Squibbs Idhifa (enasidenib) and conduct certain clinical development activities within the Idhifa development program.

In addition, the transaction includes Agios oncology pipeline and clinical programs, including vorasidenib, an investigational, brain-penetrant, dual inhibitor of mutant IDH1 and IDH2 which is currently being studied in the registration-enabling phase III INDIGO study in patients with IDH-mutant low-grade glioma; AG-270, an investigational first-in-class methionine adenosyltransferase 2a inhibitor being evaluated in combination with taxanes in patients with methylthioadenosine phosphorylase-deleted non-small cell lung cancer and pancreatic cancer; AG-636, a novel inhibitor of dihydroorotate dehydrogenase; and Agios oncology research programs.

All of Agios U.S.-based employees who primarily support the oncology business will receive a comparable offer at Servier.

Kite and Oxford BioTherapeutics establish cell therapy research collaboration in blood cancers and solid tumors

Kite, a Gilead Company, and Oxford BioTherapeutics Ltd. have entered into a research collaboration to evaluate five novel targets for a number of hematologic and solid tumor indications.

Through this collaboration, OBT will validate five novel oncology drug targets, previously identified using OBTs OGAP discovery platform, and generate antibodies against these targets. Kite and Gilead will have the exclusive right to develop and commercialize therapies based on these targets or antibodies.

Under the terms of the agreement, OBT will receive an upfront payment and will be eligible to receive additional payments based on achievement of certain discovery, clinical and regulatory milestones, as well as royalties on future potential sales.

Original post:
Tagrisso receives FDA approval as adjuvant therapy for NSCLC with EGFR mutations - The Cancer Letter

It has not been a good year for sleep. Between a pandemic, social unrest, an election, and the stresses of working (or learning, or teaching) from home, millions of us are experiencing coronasomnia. Thats why two months ago, I started to take a CBN tincture, in hopes that it would combat the hours of blue light exposure and heightened holiday-related anxiety that were plaguing my sleep habits.

With one 50-milliliter drop of Ned Sleep Blendhalf the recommended doseI drifted into a peaceful, uninterrupted sleep for eight full hours (two more hours than usual, for me). Ive since incorporated a half-dropper of Ned into my bedtime routineand while it lacks the instant catalyst that melatonin or over-the-counter medications provide, it settles my mind into a restful, deep sleep as soon as I shut my eyes.

[Photo: courtesy Ned]

We all have hectic days and tend to stay up really late, and our brains get confused about when to be alert, when to be sleepy, and when to be sleeping deeply, explains Dr. Nitun Verma, a San Francisco sleep physician and spokesperson for the American Academy of Sleep Medicine. Once upon a time when we all used to work outdoors, the sun would go down over a period of hours. It would get cooler, darker, quieter, and your brain would get the sense that it was time to go to sleep.

If youre in search of a good nights sleep, dont worryyou can still help your brain recognize its time to wind down just by building out a routine, Verma says. For example, he recommends cleaning up your workstation when youre done with work for the day. That concept helps your brain understand, Hey this activity is over. And now I get to have personal time and to relax. It shows your brain that youre getting ready to sleep.

For the rest of your evening, here are some of our best suggestions for calming down, cozying up, and getting some shut-eye.

[Photo: courtesy Prismatic Plants]Prismatic Plants Goodnight TincturePrismatic Plants Goodnight Tincture combines all the relaxing elements of cannabis without the unwanted side effects: CBD by itself is not sedativewhat it does do is help calm a busy, racing mind, says founder Sarah Polansky. If you need assistance in making your mind and body tired, then CBN is what you will want to take. Good Night features a blend of adaptogens, MCT oil, and terpenes with 300 milligrams of full-spectrum CBD and 10 milligrams of CBNenough to help you doze off, but not so much that you get a cannabis hangover the next morning, Polansky says.

[Photo: courtesy THE WELL]The Well Relax BundleWhether you believe in the power of aromatherapy or just like the scent of lavender, the Wells Relax self-care bundle is an excellent way to wind down at the end of a long day. Staff editor Lara Sorokanich says: Before I get into bed, I spray this all over my pillows and sheets. It feels so luxurious and relaxing to get into a lavender-scented bed. Clinically backed or not, the smell definitely makes me feel happy as Im dozing off.

[Photo: courtesy Oura]Oura RingWhile the Oura Ring might not put you into a deep sleep, it can certainly tell you what happens once you get there. Slip this unintrusive smart band onto your finger to track health progress throughout the day and night; it monitors everything from step count to sleep quality. By automatically measuring your sleep balance against your daily activities via the accompanying Oura app, you can be one step closer to determining daytime habits (looking at you, afternoon coffee) that keep you up at night.

[Photo: courtesy Dohm]Dohm Natural Sound MachinesWhite noise is a city dwellers best friend. The dull hum of a sound machine can help drown out disruptions like construction during the day or noisy neighbors at night without adding to the chaos. The mechanical whirling of white noise works by creating a higher-volume baseline, meaning loud, jarring noises dont make you jump. We like these simple, space-conscious Dohm sound machines that enhance an atmosphere with gentle sleep-inducing noise and sleek, inoffensive design.

[Photo: courtesy The Nue Co.]The Nue Co. Sleep DropsPlant-driven supplement brand the Nue Co.s Sleep Suite includes a tincture, capsules, and a magnesium spray thats absorbed through the skin and can be taken individually or in tandem to best tackle your level of restlessness. My approach to a good nights sleep is to relax and unwind, limiting any screen usage an hour before bed and following the same nightly routine, says Jules Miller, founder and CEO of the Nue Co. I use our Magnesium Ease spray on my joints and stomach. Half an hour before bed, I place 12 Sleep Drops under my tongue to help me to fall asleep. I also like to ensure that the room is in complete darkness to minimize any disruption caused by light.

[Photo: courtesy Uncommon Goods]Moon Beam Sleep AidThis clever, flat disc acts as a sleep-inducing metronome, projecting gentle pulses of blue light onto your ceiling for 8 or 20 minutes. Moon Beams process has a dual purpose: calming your busy mind through distraction and slowing down your breathing and metabolism, readying your body for sleep. Users inhale and exhale in time with the dimming and brightening of the blue glow, eventually drifting from 11 breaths per minute to 6.

[Photo: courtesy Bearaby]Bearaby Cotton NapperWe love the deliciously heavy comfort of the chunky knit Bearaby Cotton Napper. The hype of weighted blankets comes from studies that found the all-encompassing pressure can help release serotonin in the body while reducing the stress hormone cortisol. But unlike fellow weighted blankets on the market, Bearabys beautiful, sustainable throws get their heft from thick woven cord that also serves as a mechanism to keep sleepers from getting sweaty.

[Photo: courtesy Riley Home]RileyReversible Flannel Sheet SetThese cotton flannel sheets from Riley are thick and plush, but breathable enough for those who sleep hot. While perfect sleep temperature is subjective, a layer of lightweight warmth can keep you comfortable all night long in chillier months.

[Photo: courtesy Brooklinen]Brooklinen Mulberry Silk Eye MaskDont underestimate the power of a pitch-black room. While blackout curtains certainly help, the glow of charging electronics and late-night rumblings of my partner and cat can shake me out of a deep sleep in an instant. As far as simple solutions go, a sleep mask makes a huge difference by minimizing disruptions. Even better if its made of luxurious silk, like this one from Brooklinen, that doesnt tug my skin and lashes through a night of tossing and turning.

Fast Companymay receive revenue for some links to products on our site.

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The best products and tips for getting a better night's sleep - Fast Company

"For if one drinks much from a bottle marked 'poison,'it's almost certain to disagree with one sooner or later."Lewis Carroll, "Alice's Adventures in Wonderland"

In the early 16th century, a Swiss physician named Paracelsus changed the course of the healing arts with his theories on chemical treatments for disease. A literal renaissance man given the era, he was part scientist, part alchemist, and part philosopher. Three hundred years before the advent of Pasteur's germ theory, Paracelsus advised patients to keep their wounds clean to avoid infection. His study of chemicals revealed both their curative and harmful properties, and he noted that any treatment turns toxic once the dose is high enough. Paracelsus' simple yet profound insight that "the dose makes the poison" challenged the prevailing wisdom that poisons were inherently toxic. He noted that the known poisons of the day were substances that were toxic at low-doses. Yet, dilute these substances enough and they could be rendered harmless or, in some cases, even beneficial.

This theory is now known as dose response. It has become one of the key frameworks of environmental science, modern medicine, and public health. Put simply, it states that the larger the dose of a chemical or exposure, the greater the magnitude of its effect. Thus, low doses of a toxin can have zero to minimal effect, while large doses become deadly. For therapeutic chemicals, or "drugs," benefits initially rise with increasing doses before crossing a threshold toward toxicity, or overdose.

In modern medicine, dose response theory is foundational for both toxicology and pharmacology, and also carries over to the worlds of microbiology, virology, and oncology. Although in each scenario, the theory is labelled "dose response," its application differs according to the properties of the substance. In recent months, for example, dose response has been hotly debated alongside speculation on the exposure risk of COVID-19. What is the potential for virus exposure via the groceries you buy? What about the mail delivered to your home? Could you get sick from takeout food? The answer lies in the question: how much 'dose' is required to get ill?

A brief history ofdose response theory

For many chemical substances, the dose response theory of toxicity depends on five important variables that predict a subject's response to an exposure:

If you plot the administered dose of a substance versus its effect on a living organism, you often get a "dose response" curve that typically resembles the letter 'S'.

As you can see in the curve, low level exposures may have no effect on an organism up to a certain threshold. For example, many adults are familiar with the toxic effects of drinking alcohol just ask any college student how they feel on Sunday morning. Ripe bananas also contain trace amounts of alcohol, but few individuals eat a banana and worry about their ability to drive home. While a certain dose of alcohol causes intoxication, it has no harmful effect beneath its toxic threshold. As intoxication rises past a second threshold, its effect turns deadly.

Poisons and the canary in the coal mine

The "canary in a coal mine"is a well-known idiom that has a historical antecedent. In the early 20th century, miners brought captive birds with them into the mine shafts. The humble canary would fall dead as a result of increasing toxins particularly carbon monoxide in the air. Being a small creature with rapid respiration and a fast metabolism, toxins accumulate in a bird's system much faster than they would in larger animals. Thus, the miners received advanced warning of an exposure of which they would otherwise be unaware. In other words, the canary had a lower dose response threshhold than humans.

Animals that are prone to showing toxic effects and serve as harbingers of environmental degradation have come to be known as "sentinel species." Cats are susceptible to mercury poisoning, crayfish to water pollution, and bees to air pollution. Even in antiquity, people recognized that when the plague arrived, the rats were the first to die.

The dose also makes the medicine

If the dose makes the poison, it also makes the medicine. For medicines, small doses will have minimal to no effect. Larger doses begin to demonstrate their beneficial effect above a threshold often referred to by clinicians as the "effective" or "therapeutic" dose. Increasing doses from this threshold increases the magnitude of the therapeutic effect up until it approaches toxic levels. This range is known as the therapeutic window.

Acetaminophen, for example, is safely metabolized by liver enzymes within its therapeutic window. Metabolism is a multi-stage process that, at an intermediate stage, generates a toxic metabolite known as N-acetyl-p-benzoquinone imine (NAPQI). If a person has chronic liver disease, or if they take too much of the drug, NAPQI accumulates in their bloodstream and eventually causes permanent liver failure.

Over several centuries, medical researchers have used a process of trial and error to find therapeutic functions of substances long regarded as toxins. The bark, leaves, and seeds of the yew tree (Taxus baccata) have been known to be poisonous for centuries. The witches' brew from Shakespeare's "Macbeth" even cited "slips of yew, silvered in the moon's eclipse" as a main ingredient. Yet, the compound Paclitaxel, derived from the same plant, treats opportunistic infections in AIDS patients as well as a variety of cancers.

For cancer chemotherapy treatments in particular, one must walk a fine line, using the toxicity of a substance to preferentially destroy cancer cells without killing the patient. In this way, tumors are similar to sentinel species. The rapid rate of cellular metabolism that makes cancer cells dangerous also makes them susceptible to toxic exposures as they more quickly incorporate the dose. Cancer treatments then exploit the differential uptake of chemotherapy between healthy and tumor cells to deliver a targeted dose.

Is dose response theory always right?

Paracelsus' doctrine may have been profound, but does that mean it is universally correct? There are at least four cases that complicate dose-response theory as succinctly stated by Paracelsus:

Carcinogens. It is generally believed that there is no "safe" dose for exposure to cancer causing agents and hence, carcinogens are inherently poisonous. Although the likelihood of cancer increases with the exposure dose, a single mutation to a single DNA base pair can be enough to result in cancer.

A cancerous cell, through its uncontrolled growth, escalates its own dose. The seemingly harmless single cancer cell divides to give rise to two such cells, then four, then eight, triggering a geometric expansion towards a cancerous tumor.

Even this line of reasoning however, is disputed by additional nuance. Communities that live at high altitudes are exposed to greater levels of cosmic radiation. Assuming a linear relationship between carcinogen dose (UV radiation) and cancer even at low doses, one would expect these communities to demonstrate higher rates of certain cancers. Yet, no such evidence exists to reveal this expected cancer cluster. This has led to the hypothesis that low-doses of radiation stimulate mechanisms in the body that serve to repair DNA damage. The body's mechanism for culling dead or dangerous cells may effectively limit these micro dose exposures before they give rise to cancerous masses.

Bioaccumulators. In 1958, after noting rising mortality in birds of prey following the widespread spraying of insecticide in New England, conservation biologist Rachel Carson identified the agricultural pesticide DDT as the highly toxic culprit. This finding was published in her influential book Silent Spring. Because raptors were at the top of the food pyramid, the fish they preyed on had in turn eaten smaller fish, which had nibbled on plants contaminated by runoff. At each level of the feeding chain, DDT levels became further concentrated in the organism.

This process, known as "bioaccumulation," arises from the fact that some toxins cannot be metabolized or excreted, and thus become increasingly concentrated up the food chain. Consequently, although there may be a safe dose for a single exposure, bioaccumulation results in the exposure becoming more pronounced over time until a harmful dose is reached. Applying this principle of bioaccumulation to people, particularly those who eat meat and are, therefore, exposed to higher accumulated doses, led to the wide-scale ban of DDT in the US and other high-income countries.

Endocrine Disruptors. Compounds that disrupt the human endocrine system are another example where the apparent simplicity of the dose response curve begins to break down. Endocrine disruptors are chemicals that are similar in structure to the hormones circulating in the human body. Hormone imbalances can have dire health consequences, particularly for the human fetus. Fetal exposure to a microdose of a certain sex hormone can lead to the malformation of sex organs, while the same dose exposure would have zero impact on an adult. Even stranger, the dose response curve for endocrine disruptors may be "non-monotonic" that is, not show a consistent relationship between increasing dose and increasing effect. Small doses may yield significant effects, medium doses may have no effect, and high doses again may show an effect. Any number of puzzling curves have been proposed by toxicologists and researchers in order to explain these phenomena. They all call into question the dose response relationship conceived of by Paracelsus.

Viruses and bacteria. Like cancer, viruses and bacteria have the innate capability to escalate their own dose. A single viral particle that infects a host cell can make millions of copies of itself. This implies that, in theory, there is no lower limit or no truly safe dose. Yet, like cancers, we also do not typically see this play out. Some noroviruses may cause an infection in 50% of people exposed to as low a dose as 20 viral particles. Meanwhile, other viruses and bacteria may be harmless, or in some cases symbiotic, at much higher numbers. The human gut, for example, is a celebration of the therapeutic benefit of many bacteria and even some viruses that work to maintain the body's homeostasis.

What about for the novel coronavirus?

Studies of swab samples demonstrate that New York subways are populated by all manner of viruses and microbes, including everything from anthrax to the plague. And yet exposure of millions of subway riders to these pathogens do not lead to clinical cases of exotic diseases. Similarly, more and more evidence suggests handling a bag of groceries with traces of SARS-CoV-2 virus is not going to make most people sick.

Although in theory there may be no safe dose, as a practical matter, many humans are quite resilient to all kinds of exposures. Recent evidence demonstrates that wearing masks protects wearers by reducing the exposure dose of COVID-19.

Of course, some of us may be the proverbial 'canary in the coal mine' for certain exposures based on our increased susceptibility to the disease. And in the case of many chemicals on the market today, we are all canaries in the coal mine. The experiment, as it were, is ongoing.

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When a little bit of poison is good for you: Inside the theory of dose response - Salon

A broken heart may conjure up bittersweet stories and love songs but experiencing a traumatic event may actually cause cardiac consequences.

Broken heart syndrome, also known as Takotsubo cardiomyopathy, occurs when someone experiences sudden and acute physical or emotional stress, which can rapidly weaken the heart's left ventricle.

Here's what you need to know about the causes, symptoms, and treatment for broken heart syndrome.

Broken heart syndrome, which was first described in Japan during the 1990s, is a condition where the left ventricle the heart's primary pumping chamber balloons out, while the base of the heart contracts. This may be dangerous because it negatively impacts the heart's ability to pump blood properly.

Conversely, a heart attack happens when blood flow, which brings oxygen to the heart, is restricted or entirely cut off. Although heart attacks and Takotsubo cardiomyopathy are both types of muscle heart failure that can cause similar symptoms, there are some key differences worth noting.

According to Jay Woody, MD, an emergency medicine physician and chief medical officer of Intuitive Health, heart attacks are often caused by blockage from fatty build-up known as plaque in the wall of the arteries which can lead to a clot in the blood vessel that impedes blood flow to the heart muscle. Takotsubo cardiomyopathy, meanwhile, is triggered by a severe emotional or physical response that affects the heart muscle directly.

Broken heart syndrome can set in even if you're otherwise healthy, according to the American Heart Association, which is why it's important to understand the causes and symptoms.

According to Woody, the name "broken heart syndrome" refers to the fact that the condition can be brought on by emotionally traumatic events that negatively impact the physical heart.

He says the most common example of a stressor that can lead to this condition is grief from losing a loved one but notes that intense feelings of fear, anger, surprise, and other emotions can also be a trigger.

Some other events that might cause this condition include:

A 2020 study discovered an uptick in patients diagnosed with Takotsubo cardiomyopathy since the coronavirus outbreak reaching 7.8% compared to 1.7% before the COVID-19 pandemic. Additionally, patients with this condition during the pandemic were found to have a longer hospital stay than those hospitalized pre-pandemic.

Researchers noted that the COVID-19 pandemic has added multiple layers of stress into people's lives not only are many dealing with economic changes, emotional issues, loneliness, and isolation, but they're also grappling with constant concerns about themselves or their loved ones becoming ill. They concluded that this additional stress can have physical effects, as evidenced by the increasing diagnoses of Takotsubo cardiomyopathy.

Broken heart syndrome can also be caused by physical stressors, including:

Even positive events, like walking into a surprise party or winning the lottery, can bring on Takotsubo cardiomyopathy.

"Regardless of the cause of stress, the body's response is similar: to secrete a large amount of the stress hormone adrenaline," says Jennifer Haythe, MD, a critical care cardiologist at Columbia University Center. "In some instances, this can lead to Takotsubo cardiomyopathy, which can mimic a heart attack."

While Takotsubo cardiomyopathy is seen in men and younger women, a 2015 study found that a staggering 89.8% of cases occurred in women between the ages of 58 and 75. The most common triggers were found to be physical (36%), followed by emotional shock (27.7%). Notably, a trigger could not be found in 28.5% of patients. The study also revealed that patients with Takotsubo cardiomyopathy were almost twice as likely as those with acute coronary syndrome (such as heart attack) to have a psychiatric or neurological disorder.

"Patients who have broken heart syndrome may experience chest pain, shortness of breath, and low blood pressure very shortly after an extremely stressful event," says Woody.

According to Johns Hopkins Medicine and the American Heart Association, other symptoms and signs of Takotsubo cardiomyopathy include:

These symptoms may set in anywhere from minutes to hours after someone has gone through a physically or emotionally stressful event.

"Some people describe it as feeling like an elephant is sitting on their chest," says Haythe. "Sweating, jaw pain, left arm pain, nausea, vomiting, lightheadedness, palpitations, and mid-epigastric discomfort are all possible symptoms as well."

If you feel any new symptoms in your chest, or have crushing chest pain or shortness of breath, experts urge you to seek medical attention immediately.

"Heart attacks have similar symptoms as broken heart syndrome, so it's important to get a diagnosis because heart attacks can be fatal," says Woody.

When a patient experiences symptoms similar to broken heart syndrome, medical professionals will typically rely on imaging studies, blood tests, and cardiac biomarkers to observe any potential abnormalities before making an official diagnosis.

Woody says that clinicians often use a cardiac MRI or administer an echocardiogram (cardiac ultrasound) that determines whether or not there is ballooning in the left ventricle, thus signifying Takotsubo cardiomyopathy. They may also use coronary angiograms, a procedure that uses X-ray imaging, to rule out a heart attack.

While it can take up to two to three months to recover after a heart attack, Woody says a person will typically recover from broken heart syndrome within one to six weeks, making a full recovery within one to two months.

A 2015 study revealed that the rate of death for patients with Takotsubo cardiomyopathy was 5.6% per year. While death is rare, heart failure occurs in roughly 20% of patients.

Treatment for broken heart syndrome will depend largely on which symptoms the patient is experiencing, and that, according to Woody, will dictate the severity of the condition. He states that clinicians will often recommend medications like beta-blockers, ACE inhibitors, and diuretics. They may also give aspirin to patients who show plaque buildup in their artery walls.

Beta-blockers and ACE inhibitors can be effective in reducing the effects of stress hormones, thereby helping to prevent a recurrence. Meditation and exercise are also proven to be effective strategies for reducing stress, which may play a role in triggering the disorder.

Some of the complications that can result from broken heart syndrome, according to Woody, include fluid in the lungs, or irregular heartbeat. Obstruction of blood flow from the left ventricle, and rupture of the ventricle wall, are also possible, though rare.

"Symptoms can be treated effectively by medical professionals and are usually not long-lasting," he adds. "Broken heart syndrome can be dangerous, but the condition improves rapidly, which means patients with a naturally strong heart shouldn't experience lasting effects."

Broken heart syndrome can be brought on by both physical and emotional stressors. The most common signs of this condition are chest pain and shortness of breath and you can experience these symptoms regardless of whether or not you have any history of heart disease .

Although broken heart syndrome is short-term and easily treatable, Woody says it's still important to seek medical support to prevent it from causing lasting heart damage, which can lead to other symptoms.

Haythe says that people who have experienced one episode of Takotsubo cardiomyopathy are at risk for a recurrence. However, with quick recognition, exclusion of other causes, and proper treatment, she says this condition has an "excellent prognosis," with most patients making a complete recovery.

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Broken heart syndrome is real here's how physical and emotional stress can affect your heart - Insider - INSIDER

I'm a physician in Boston, and I've been obsessed with the coronavirus pandemic since the first stories trickled out of China into my consciousness. Every day I listen to podcasts and medical lectures by a long line of virologists, epidemiologists, and infectious-disease doctors. Every week, I write an essay for my friends and family in my area about what we've learned about COVID-19 and how to protect ourselves.

My sons - Mackenzie, 24, and Cooper, 21 - live nearby and have been what I call "COVID-conscious" since the start. Both kids work and study from their apartments, have small friend pods, have excellent COVID-19 hygiene, particularly with me and anyone who falls into a high-risk group, and both had stayed mostly bubbled at home the previous two weeks.

In fact, we were masked except when actively putting food in our mouths, pulling our masks back up into place between servings and when chatting during the meal.

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But then on Saturday morning, while I was walking with a friend, Kenzie texted me saying, "Sooooo, I have bad news." Half a minute later he sent a second text that read, "I feel horrible."

Read more: COVID-19 threatens to create a 'lockdown generation' in Europe: Here's why young people could be the ones paying for yet another crisis

All I could think was, "Why, why, why didn't we just skip Thanksgiving this year? And now it's too late to stop whatever tsunami is coming our way."

This is exactly how COVID-19 spreads: A person, like my beloved son, can have it, be contagious, but have no symptoms at all, not a single clue, for several days before getting sick.

This is why we were so meticulously careful about our Thanksgiving. We knew it was possible one of us could be that asymptomatic contagious person - not likely, not even probable. Kenzie has five friends in his bubble. All had been tested the week before for travel and were negative. All have been tested since and stayed negative, and all were asymptomatic. He had shopped, carefully, at only a couple of large stores.

And as it turned out, the precautions we did have in place worked. Cooper and I are COVID-19 negative. And Kenzie had a rough week but is getting better. We're all getting better.

Was it worth it to have Kenzie feel immense guilt about potentially exposing us? Was it worth the discomfort of having to tell his contacts they needed to be tested and then go into 10 days of quarantine?

And Christmas in 2020?

No possible way. Not a bit. Not a chance.

This story originally appeared on Schoenthaler's Facebook page and on The Boston Globe website. It has been republished with permission.

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I'm a doctor who tried to plan an extremely safe Thanksgiving for 3 people. It wasn't worth the scare it put u - Business Insider India

Feeling stressed out around the holidays? These tips might help. (WYDaily/ Courtesy of Unsplash)

As we head into the holidays, W&M News spoke with Dr. Elizabeth De Falcon to learn about ways relieve stress and practice self-care over winter break, to strengthen our collective immune systems. Dr. De Falcon is a practicing physician with William & Marys Health Services. She is a licensed pediatrician and Fellow of the American Academy of Pediatrics.

In the simplest terms, stress is just your bodys reaction to any change that requires response. So, it could be anything: a mental strain, a physical strain or even an emotional strain. Honestly, its different for every person. What stresses me out may not stress you out, but if were talking about physiology, then our stress response would be mostly the same.

Without going into the specific names of all the different parts of your brain, its just that your brain perceives stress or danger or threat. Then it sends out a signal from what is essentially the command center of your brain to the rest of your body, through the nervous system. Then the nervous system starts acting on a fight or flight response and all these different neurotransmitters and hormones get released. All these different substances start flowing through your body just to get you prepared to respond to that stressor.

A lot of times, youre not even aware of it. Most of the time the threat comes and goes, and as the threat goes away, the stress response decreases. Think of a car whizzing past you on the street. Its stressful for a second, but the feeling is very short-lived. Its important to understand that not all stress is bad. It serves an important biological purpose. The stress response has been vital to our survival and evolution. When the saber-toothed tigers were hunting us down, our bodies learned how to respond to that.

If you translate that to now, lets say youre taking a test and you feel a little bit stressed. Youre supposed to have a certain level of stress, because its your bodys way of motivating you to focus on something important. After the test is done, theres this sigh of relief because that stress is gone and your body just goes back to a kind of homeostasis where its feeling ok.

But sometimes that stress hangs around for a little while. Thats when you start running into problems. You may find that even though the threat is gone, youre not feeling better. You may be experiencing increased heart rate and breathing or generally feeling edgy all the time. Thats a sign that youre bumping over into a low-level, acute stress or chronic stress state.

Thats when we start to think about cortisol. Youve probably heard about cortisol as a stress hormone. In the moment, it actually helps your body boost its immune system and decrease inflammation, but if its there for a long time, then you start to get into different problems.

I always tell people to seek medical help if they start seeing signs of chronic stress. Some of the red flags would be that you feel in a low mood all the time. You may stop hanging out with your friends or your family. Youre just kind of retreating and not interested in the things you used to be interested in. You may be sleeping too much or too little. Some people experience physical symptoms. They have an upset stomach or heartburn or headaches, because their blood pressure is up. They might feel a knot in their chest. All of those things could be signs that youre experiencing anxiety, so you would definitely want to see your doctor at that point.

It comes down to the basics of general healthy living. For example, if youve not been on a good sleep schedule over the semester, you really need to prioritize getting on a healthy sleep scheduleand make it a realistic schedule that you can keep doing once we get back on campus. If you were not addressing your dietary needs during the semester, start to incorporate healthy, nutrient-dense types of foods into your diet.

Also, exercise is super important. Just from a perspective of improving your cardiovascular health and improving your circulation, regular exercise will help get all those immune cells pumped around your body. You dont want to smoke and try to minimize your alcohol intake.

Then, of course, what weve all been focused on over these last nine month is taking steps to minimize infections. So, being very diligent about washing your hands, keeping your distance from pretty much anyone who doesnt live in your house, and wearing a mask if you have to go out and about.

When you have a healthy immune system, when its functional, you dont even know its there. Its protecting you from things that are trying to kill you, viruses and bacterial infections, but you arent even aware of it.

But just like a car runs out of gas when left idling, if you are not fully addressing the things that boost your immune system, eventually that car will run out of gas and then that leads to a whole host of problems. You might start noticing that youre getting more colds or struggling to get over minor illnesses. Thats really just because when your stress response is revved up all the time, it has the opposite effect on your health and it starts down-regulating your immune system.

This is something I always recommend to my patients: practice gratitude. Its such a simple, easy thing that anyone can do. It doesnt have to be complicated. Just get a little notebook, or even make mental notes, and focus on three things that youre grateful for in a day. No matter how crummy the day is, theres always something that we can find that we can be grateful for.

Studies show that if you practice gratitude, there are positive changes in your brain that actually change your outlook on things. Along those lines, theWellness Centerhas all kinds of wonderful mindfulness, meditation and exercise resources available online. They make it really easy to access, so Id also recommend trying out some of those offerings.

Adrienne Berard is a research communications specialist at William & Mary News and this story was published on Dec. 18.

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Tips for staying healthy and managing stress over the holidays - WYDaily

There is no proven way to permanently thicken hair if you are healthy and have no underlying health conditions. But, there are lifestyle adjustments to improve your overall hair health and prevent breakage.

Here are common causes of thin hair and five tips for healthier, thicker hair.

The causes of thin hair include:

If you are concerned about frequent hair loss, reach out to a dermatologist, says Sara Wasserbauer, MD, a hair restoration surgeon and President of the Board of Directors for the American Board of Hair Restoration Surgery.

"The earlier someone starts therapies, the more likely they are to be effective," Wasserbauer says. "If you are losing more than 100 hairs per day, or if your hair is less thick when you run your hand through it, it is worth seeing a hair expert."

A doctor can determine if you can treat thin hair without medical intervention, or if it is a sign of alopecia a more severe condition in which hair falls out in patches or causes balding.

If your hair loss is not due to an underlying health condition, you may be able to thicken your hair with the following lifestyle changes:

A nutritious diet is critical to hair health, says Sanusi Umar, MD, CEO and medical director of Dr. U Skin and Hair Clinic in Manhattan Beach, California. This is because adequate nutrition ensures hair follicles construct hair shafts of normal thickness.

According to Umar, certain nutrients are essential to the thickness and growth of hair, like:

Cortisol, the stress hormone, disrupts the functioning of the hair follicle and contributes to thinning hair. A 2016 study found high levels of cortisol can cause certain proteins in hair to break down.

It is important to differentiate between different types of stress, Wasserbauer says. If you experience a stressful event, you may notice a period of hair loss and accelerated thinning, but the hair usually recovers within a year. Ongoing hair loss is more serious, and unless it is caught, diagnosed, and treated, it may result in permanent loss.

If you're concerned stress may be causing hair thinning, you can alleviate stress and lower cortisol levels by:

A hormone imbalance, such as during pregnancy or menopause, can cause thinning hair. A decrease in estrogen or an increase in testosterone levels can thin hair as well, Umar says.

Research found an imbalance of hormones like estrogen, progesterone, and prolactin can all contribute to hair loss. Hair loss can also be due to an imbalance of thyroid hormones, Umar says.

Signs of a hormone imbalance, like a thyroid condition, include:

If you think a hormone imbalance may be causing thin hair, reach out to your doctor, Umar says. A primary care physician may refer you to a dermatologist, who specializes in skin and hair, or an endocrinologist who specializes in hormonal imbalances.

Heat styling products, like blow dryers, straighteners, and curling irons all weaken the hair shaft and fiber, Umar says. These products damage the cuticle on the outer layer of the hair, especially if the heat setting is set too high or you use a heating product daily.

"Using heating styling products excessively can cause breakage and cause the scalp to become stressed thus leading to thinning hair," Umar says.

A 2004 study found using a curling iron causes hair to weaken and break, though hair treated with a conditioner showed less damage than hair that was not.

Another 2011 study found using a blowdryer caused more surface damage to hair than natural drying, but how you use a blowdryer matters. For instance, the study found blow drying hair at a distance of 15 cm with continuous motion caused less damage than letting hair air dry or using a hair dryer without motion very close to your hair.

If you use heat styling products regularly and have noticed your hair thinning, try reducing how often you use these products. To prevent damage, you should also limit other treatments, like hair dye, bleach, and chemical treatments.

Sulfates are chemicals found in most shampoos and soaps that provide the "sudsy" effect when you lather them up.

Sulfates also strip hair of its natural oils and moisture, Umar says, causing it to become dry and brittle, which makes it break more easily.

However, switching to a sulfate-free shampoo won't stop hair loss, Umar says. Using a sulfate-free shampoo can help preserve the natural oils in your hair, reduce irritation, and potentially prevent future damage, like hair breakage.

If you have no underlying health conditions causing hair loss, there is no proven way to thicken your hair. However, you can improve overall hair health by eating a nutritious diet, limiting heat styling, and using a sulfate-free shampoo. Healthier hair means less damage and breakage, which can help hair grow longer and thicker.

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5 tips to get thicker hair and common causes of hair loss or thinning - Insider - INSIDER

Those cookies you smell at the holidays, the ice cream that makes your eyes light up in the summertime and the candy jar full of tempting chocolates all have one thing in common they're loaded with sugar.

There's something about sugar that speaks to your brain, evoking feelings of happiness with each bite of food or each sip of your favorite sugary drink you consume. It's part nostalgia and part chemical reaction. The more you eat, the more you crave, which can lead you down a road of long-term health problems.

We're here to discuss what makes sugar so habit-inducing, how you can kick your cravings and which foods you can substitute to please your sweet tooth.

What's wrong with sugar, you ask? Everything. Outside of making things taste better, sugar has no nutritional value and is full of empty calories. These calories can create weight problems and, in turn, heighten your risk of heart disease and stroke.

That's only the physical downside. The psychological component is real, too. Sugar releases dopamine and can increase serotonin production, a hormone that can boost your mood.

In reality, sugar isn't any different than comfort food or a satisfying fast food meal loaded with simple carbohydrates. These carbohydrates are high on the glycemic index, meaning it takes less time to turn them into glucose. During this quicker digestion process, you may feel good in the short term, but hunger will quickly set in since sugary foods lack nutrients and leave you unsatisfied.

It can turn into a vicious cycle. At first, the sugar you eat tastes good, bringing on a "high" when your brain initiates the dopamine release. Then, the sugar causes your insulin levels to increase, leading to a drop in blood sugar levels. As your blood sugar falls, your appetite and hunger levels increase. Your body then craves sugar again to fix any hunger deficiencies or feelings of unease, even if the fix is only temporary.

According to the American Heart Association, eight out of 10 adults are trying to lower their sugar intake. On average, adults consume around 77 grams of sugar a day. That equals about 60 pounds of sugar over the course of a year. Imagine lugging around a dozen five-pound sacks of sugar. That's what you're putting in your body!

If you're determined to kick your sugar habit, it's OK to stop cold turkey. The Mayo Clinic recommends taking a two-week break from sugar to reset your body. This doesn't have to be an outright cleanse, but try to limit yourself to foods with little to no added sugars or sweeteners shoot for less than 5 grams of added sugars per serving.

Start by cutting out sugary drinks. They are the biggest culprit, accounting for almost half of the added sugars Americans consume. A 12-ounce can of soda can contain as much as 10 teaspoons of sugar. Think of it this way: The American Heart Association recommends men eat only nine teaspoons of added sugar each day, while women and children should consume six teaspoons. Just like that, you can exceed your daily sugar allotment in five or six gulps of your favorite soda.

The spoonfuls and spoonfuls of sugar in soda explain why there are so many calories in a drink the size of your hand. There are four calories in a gram, so a soda containing 40 grams of sugar has 160 calories. It's easy to see how calories add up when that 12-ounce soda turns into a 44-ounce drink at your favorite fast food restaurant.

You should also stay away from any baked goods, desserts and candy. Cereals, even the so-called "healthier" options, still have added sugars that can creep up on you. Then there are unassuming foods, such as pizza or pasta sauces, that you wouldn't normally associate with having added sugars. A half-cup of a store-bought marinara sauce contains anywhere from 2 to 4 grams of added sugar, which amounts to a teaspoon.

As a general rule, look for words that end in "ose" sucrose, fructose, glucose, maltose, lactose or dextrose. This is an easy indicator to spot added sugars. Don't let ingredients that sound better for you fool you, either. Honey, agave, maple syrup, brown rice syrup and juice concentrate are still added sugars.

Now that you've reduced your sugar intake, what comes next? For starters, introduce more whole foods whole grains, fruits, vegetables and lean meats to your diet. Many fruits and vegetables still contain natural sugars, but the starch and fiber in these foods slows the digestion process and leaves you feeling more full. You can learn more by reading our blog post on healthy carbs.

Eating fruit for an after-dinner snack can satisfy your cravings for sugar without leaving you feeling like you've cheated. Certain fruits, such as grapes and bananas, have high sugar contents. Berries are generally a low-sugar choice, so sneak some blueberries, raspberries or blackberries into your yogurt or oatmeal.

Ditching sugary drinks isn't easy, but try swapping them for water or sparkling water. Better yet, try flavored sparkling water. The carbonation will mimic the fizz from soda without the added sugar or calories. For more on sparkling water, check out our blog post on carbonated drinks.

When making food selections at the grocery store, be wary of hidden sugars that are often added to low-fat products. Things with fat tend to have flavor, so removing fat from products can leave them bland. Food manufacturers add sugars back into products to make them more enjoyable. Any benefit you think you're getting from a product with less fat may be just as bad for you if it's loaded with additives or sugars.

It's important to remember correcting bad sugar habits doesn't mean an outright boycott of sweet foods. Instead, take control by adding small amounts of sugar. For example, drizzle a small amount of honey on your yogurt to treat yourself. It's better than the alternative, which is pre-packaged flavored yogurts loaded with added sugar.

If you place an order at your local coffee shop, it's no longer a question of if you want cream or sugar added. Artificial sweetenersare just as popular of an option nowadays to help curb sugar habits.

These synthetic sugar substitutes received a bad reputation years ago for their link to cancer, but subsequent studies haven't found a clear connection to causing cancer in humans, according to the National Cancer Institute.

With those concerns out of the way for now, the FDA has approved five artificial sweeteners for use: aspartame (Equal), acesulfame-K (Sweet One), neotame, saccharin (Sweet'N Low) and sucralose (Splenda).

But just because the FDA approves their use doesn't mean you should swap sugar for artificial sweeteners and keep the same diet. Artificial sweeteners can temporarily help by weaning you off added sugars, but long-term use could play a role in how you view foods.

Think of artificial sweeteners as a concentrated version without the calories a little goes a long way. According to Harvard Health, the sweetness from artificial additives can make you more likely to develop a sweet tooth and crave sweets even more. Plus, the psychological component can alter the way you think. For example, if you tell yourself you're saving calories by drinking a diet soda instead of a regular soda, you may be more inclined to eat cake for dessert. In this case, you cancel out any benefits of drinking a diet soda with something full of added sugars.

Before you make any dietary changes or consider cutting sugar from your daily routine, connect with an INTEGRIS Health primary care physicianto learn more about how to implement changes.

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There is no proven way to permanently thicken hair if you are healthy and have no underlying health conditions. But, there are lifestyle adjustments to improve your overall hair health and prevent breakage.

Here are common causes of thin hair and five tips for healthier, thicker hair.

"The earlier someone starts therapies, the more likely they are to be effective," Wasserbauer says. "If you are losing more than 100 hairs per day, or if your hair is less thick when you run your hand through it, it is worth seeing a hair expert."

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If your hair loss is not due to an underlying health condition, you may be able to thicken your hair with the following lifestyle changes:

Cortisol, the stress hormone, disrupts the functioning of the hair follicle and contributes to thinning hair. A 2016 study found high levels of cortisol can cause certain proteins in hair to break down.

It is important to differentiate between different types of stress, Wasserbauer says. If you experience a stressful event, you may notice a period of hair loss and accelerated thinning, but the hair usually recovers within a year. Ongoing hair loss is more serious, and unless it is caught, diagnosed, and treated, it may result in permanent loss.

A hormone imbalance, such as during pregnancy or menopause, can cause thinning hair. A decrease in estrogen or an increase in testosterone levels can thin hair as well, Umar says.

Research found an imbalance of hormones like estrogen, progesterone, and prolactin can all contribute to hair loss. Hair loss can also be due to an imbalance of thyroid hormones, Umar says.

Heat styling products, like blow dryers, straighteners, and curling irons all weaken the hair shaft and fiber, Umar says. These products damage the cuticle on the outer layer of the hair, especially if the heat setting is set too high or you use a heating product daily.

A 2004 study found using a curling iron causes hair to weaken and break, though hair treated with a conditioner showed less damage than hair that was not.

Sulfates are chemicals found in most shampoos and soaps that provide the "sudsy" effect when you lather them up.

Sulfates also strip hair of its natural oils and moisture, Umar says, causing it to become dry and brittle, which makes it break more easily.

If you have no underlying health conditions causing hair loss, there is no proven way to thicken your hair. However, you can improve overall hair health by eating a nutritious diet, limiting heat styling, and using a sulfate-free shampoo. Healthier hair means less damage and breakage, which can help hair grow longer and thicker.

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5 tips to get thicker hair and common causes of hair loss or thinning - Business Insider India

Menstruation or monthly period is the most familiar phenomenon of a female body going through the reproductive age. At a particular time of each month, our uterus sheds off the ovarys unfertilized egg and all other residual chemical and biological waste materials. Usually, every healthy female has a menstrual cycle of twenty days, and it lasts for three to seven days. The time may come forward or halt for two to five days due to normal physiological conditions. But, if it exceeds more than a week or goes over a month, there is a reason to worry. What do you think first when you miss a period date? Most appropriately, a married female will think about pregnancy. Pregnancy causes a physiological halt of the menstrual cycle for nine months. But, other than that, there several more reasons for a . Here in this article, we will focus on some critical health conditions that may cause delayed menstruation in females. These conditions require immediate physicians attention.

Pregnancy

We already mentioned earlier that if your cycle is one or two days different from the last process, it is not a menstruation delay. But, some legit health conditions push the menstruation future later. For example, suspected pregnancy is one of the most common causes. If you are a married or sexually active female and miss more than seven days after the expected menstruation date, there is a good chance of pregnancy. You may complete the strip test to detect pregnancy at home. But, these procedures do not give accurate results all the time. So, taking a physicians advice will be the best option. Because taking any step without the right precaution can harm your health.

PCOS

Polycystic ovary syndrome or PCOS is one of the most common gynecological problems nowadays in the world. There are multiple cysts of bulge formation on the wall of the uterus, both inside and outside. Cysts or these bulges remain harmless initially, but they suck out blood from the surroundings to ensure the nutrients. That is why the patients body does not get enough blood supply or fails to excrete the unfertilized egg. Delayed menstruation and anemia is an overall presentation of a patient with PCOS.

Obesity

Obesity is the main culprit for most of the diseases in the human body. Extra fat accumulation alters the enzymatic and hormonal activities in the body that may cause delayed menstruation or complete amenorrhea at some time. Low body weight (LBW) is another major cause of delayed menstruation, similar to obesity. Eating disorders such as anorexia nervosa or bulimia, are pervasive in people, especially teenagers and models. But, trying to be thinner than ever may cost you more than the external beauty.

Stress

Stress and tension throw your hormones into a frenzy. Excessive cortisol, also known as the stress hormone, causes alterations in estrogen and progesterone secretion. Rhythmical alteration in the concentration of these two hormones is essential to keep up the normal menstruation cycle. The same thing goes with alcohol consumption and smoking too. These narcotic objects cause delayed and painful menstruation very often. Hormonal imbalances like thyroid storm, thyrotoxicosis, and low thyroid hormone are also responsible for delayed menstruation.

Delayed menstruation brings a lot of tension with it. It can be due to regular physiological alternation or merely a change in food habits. But, there can be deadly underlying diseases behind it. You cant be sure without proper examination and tests. So, consult your doctor if you are facing delayed menstruation frequently.

Laila Azzahra is a professional writer and blogger that loves to write about technology, business, entertainment, science, and health.

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A late period: things that might happen to your body - Omega Underground

Heavy menstrual bleeding (HMB) or menorrhagia is one of the most common reasons for which women seek a Gynaecologists help. There are over 355 million menstruating women in India and about 60% of them may need medical help at some time in their lives to deal with heavy periods.Why do women have periods?Imagine a life without periods - no bleeding, no pain, no sanitary napkins and no tampons .freedom. Before you get too carried away with that utopian thought have you ever wondered why women have periods? Well, because we are special of course! Every month the womb prepares for a possible pregnancy and when this does not happen it sheds the lining of the womb which results in a period or menses. This usually happens once a month and a woman bleeds on an average for 5 days. The normal cycle varies from 21 to 35 days and the bleeding can last from 2 to 7 days. So, having a regular period most often indicates that a woman is ovulating every month. So ladies the next time you moan about your periods remember it is your monthly reminder that you are capable of having a baby!

How do I know if I have HMB?Do have heavy periods, needing constant change of menstrual hygiene wear, staining of clothes, cramps and severe pain in your tummy? Are you personal and professional life affected during your period days such that you cannot maintain your usual activities? Do you dread that time of the month? If the answer to most of the questions is yes, you are suffering from heavy periods and you need to see a doctor.

Symptoms of HMB

If you have any of the following symptoms you may be suffering from heavy menstrual bleeding and may need medical help:Soaking through one or more sanitary pads or tampons every hour for several consecutive hoursNeeding to use double sanitary protection to control your menstrual flowNeeding to wake up to change sanitary protection during the nightBleeding for longer than a weekPassing blood clots larger than a quarterRestricting daily activities due to heavy menstrual flowSymptoms of anemia, such as tiredness, fatigue or shortness of breath

What are the causes of HMB?About 60% of the women who consult me, do so because they have a menstrual problem. Heavy periods can be caused by hormone problems, uterine problems and other causes. Given below is a brief overview of the causes of heavy bleeding.

Hormone imbalanceIn a normal menstrual cycle, a balance between the hormones estrogen and progesterone regulates the buildup of the lining of the uterus (endometrium), which is shed during menstruation. If a hormone imbalance occurs, the endometrium develops in excess and eventually sheds by way of heavy menstrual bleeding.A number of conditions can cause hormone imbalances, including polycystic ovary syndrome (PCOS), obesity, insulin resistance and thyroid problems.Uterine fibroids - These are benign tumors of the uterus which may cause heavier than normal or prolonged menstrual bleeding.

Uterine Polyps - Small, benign growths on the lining of the womb cause heavy or prolonged or irregular menstrual bleeding.Adenomyosis - This condition usually affects women in their forties. Glands of the lining of the uterus become embedded in the muscle of the uterus and cause heavy, painful periodsIntrauterine device (IUD) - Menorrhagia is a side effect of using a nonhormonal intrauterine device for birth control.

Cancer - Uterine cancer and cervical cancer can cause excessive menstrual bleeding, especially if you are postmenopausal or have had an abnormal Pap test in the past.Inherited bleeding disorders - Some bleeding disorders such as von Willebrand's disease, a condition in which an important blood-clotting factor is deficient or impaired can cause abnormal menstrual bleeding.Medications - Certain medications like anticoagulants or blood thinners, can cause heavy menstrual bleeding.

Other medical conditions - A number of other medical conditions, including liver or kidney disease, may be associated with menorrhagia.

HMB Treatment options in the 21st Century

Treatment depends on the under lying cause of HMB can be divided into Medical, Surgical and Non-Surgical Procedures.

Medical

Drugs: The most commonly used non-hormonal drugs are Tranexamic Acid and Mefenamic Acid.

The Combined oral Contraceptive pill and Progesterones are hormonal drugswhich are used to treat this condition.

A hormonal Intra uterine device or system (IUS) has a small amount of progesterone hormone impregnated into it and releases it locally. It is inserted into the uterus and acts by thinning the lining of the womb, thus reducing the amount of blood lost during menstruation. Research has shown that this is the most effective form of medical treatment in suitable women.

Surgical and non-surgical proceduresHysteroscopy and/or Laparoscopy: If the HMB is due to fibroids or polyps these can be surgically removed by Hysteroscopy and/or Laparoscopy or by the traditional open method.

Endometrial Ablation: This procedure involves destroying (ablating) the lining of the womb (endometrium). The procedure uses a laser, radiofrequency or heat applied to the endometrium to destroy the tissue.

Endometrial resection: In this procedure an electrosurgical wire loop is used to remove the lining of the womb.This results in lighter bleeding. However, in women considering a pregnancy this procedure is not recommended.

Uterine artery embolization: When HMB is caused by large fibroids (more than 3 cm) this procedure helps shrink the fibroids (in selected cases) by blocking the uterine arteries and cutting off the blood supply to the fibroids. During this procedure, the doctor passes a catheter through the large artery in the thigh (femoral artery) and guides it to the uterine arteries, where the blood vessel is injected with materials that decrease blood flow to the fibroid.

HIFU: High Intensity Focused ultrasound is a non-invasive way to treat uterine fibroids. Using this treatment method in conjunction with image guidance, the physician directs a focused beam of energy through the patients skin, superficial fat layer, and abdominal muscles to heat and destroy the fibroid tissue without damaging nearby tissue or the tissues that the beam passes through on its way to the target.The treatment is conducted with the patient awake and uses either magnetic resonance (MR) or ultrasound (US) guidance.

Link:
Heavy menstrual bleeding What you should know - Times of India

When the long summer days begin to slip away and temperatures begin to drop, its not uncommon to feel down in the dumps. Many may begin to feel resigned and sad as early as the fall when facing bone-chilling weather and increased isolation during the darkest time of any year, but its possible many more may feel affected by the challenges that this winter may bring.

The lethargy and cabin fever can range from mild winter blues to seasonal episodes of depression called seasonal affective disorder (SAD)

There are certain people who are susceptible to these changes when you get to the autumn and winter when the daylight gets shorter and its darker, explains Dr. Norman Rosenthal, a clinical professor of psychology at Georgetown University School of Medicine who lead the team that first described SAD in 1984 at the National Institute of Mental Health.

Rosenthal, who wrote a book about the seasonal depression titled Winter Blues, says that people in winter often over-eat, over-sleep and experience loss of energy, interest and more as the days grow shorter.

They can have difficulty in their relationships because they get socially withdrawn. They can have trouble at work because they dont concentrate and function as well. And this can all accumulate to the point that they feel quite depressed, Rosenthal tells TIME.

While many are able to stave off these creeping seasonal mood swings by spending quality time with loved ones or participating in activities that boost their mood, looming COVID-19 restrictions and lockdowns may make this years winter blues the most brutal yet. To help keep your mental health at its best, here are some possible, expert-approved ways to lift your spirits during the darkest time of year.

Lack of light is widely recognized as a trigger that affects peoples moods as they get less exposure to natural sunlight. A study of North America found that the prevalence of SAD increased the further north the subjects lived, as the hours of daylight decrease the further away one lives from the equator.

Both Rosenthal and Dr. Kelly Rohan, a professor and director of clinical training at the University of Vermont, recommend increasing your exposure to light every day, whether its inside or outside of your home.

Walk or do activities outside

Instead of staying cooped up at home, Rohan advises that you bundle up and get outside before those fleeting rays of sunshine disappear.

As long as youre not in a complete lockdown, get outside and walk, spending some time in nature breathing fresh air, Rohan advises, adding that you should make sure to adhere to CDC and local public health guidelines.

Seeing color in nature, like the little bit of greenery and getting direct sunlight exposure, all of these things are good for mental health. You just need to maintain a reasonable amount of distance between yourself and other people, she says.

If youre looking for a way to stay warm, dont forget to add layers. Windbreaker jackets for men or women can keep the chill out of your bones outside, and a reusable face mask will help protect you and everyone around you from infection.

Bright Light Therapy

If going for a walk outside simply isnt enough or you cant leave your home, Rosenthal recommends getting your daily dose of light with therapeutic light boxes.

Bring light into your home, Rosenthal advises. Use them for as little as 20 to 30 minutes in the morning, and you can start to feel a lot better.

Rosenthal, who pioneered bright light therapy after studying seasonal affective disorder, noted that its important to do your research before purchasing any bright light therapy lamp.

Lux is a measurement of light; 10,000 lux is how much was used in the research studies that showed the beneficial effects of lux. And [the bright light therapy lamps] need to be from established companies and screen out the ultraviolet light, Rosenthal explains. According to Rosenthal, the lights used in research studies often measure about one-foot by 18 inches. Having a larger lamp gives you more room to move around and ensures you get enough light exposure, he adds.

I like ones that are angled down towards the eyes, theyre the most comfortable he notes.

If youre in the market for a therapeutic lamp, the Carex Day-Light Classic is a way to bring extra light into your life.

Many experts believe that we can often feel deflated and lethargic during the darkest time of year because of lights influence over our sleep and circadian rhythms.

The most popular theory is that a later dawn in the winter triggers a slower-running circadian clock that is out of sync with the dark and light cycle, Rohan explains. This is our central biological timekeeper in the brain that changes and regulates our bodys 24-hour circadian rhythm which includes sleep, our core body temperature and melatonin releasethe hormone of darkness, she adds.

For this reason, Rohan and Rosenthal emphasize that regulating sleep is vital to getting your winter blues under control.

Natural sleeping aids

If you have trouble falling asleep at night, many people take melatonin supplements, a hormone your brain produces in response to darkness, to help get them on a regular sleeping schedule. Rosenthal recommends taking between one to three milligrams at night. If youd rather not ingest a sleeping aid, slip a lavender sachet inside your pillow covers to help you fall fast asleep.

Dawn simulator

Rosenthal also recommends a dawn simulator to help regulate your sleep cycle. A daylight or dawn simulator helps you wake up in the morning, says Rosenthal. I find it much nicer to awaken to an illuminated room than to awaken to darkness.

But the Hatch Restore, one of TIMEs Best Inventions of 2020, does more than just getting you up in the morning. Its designed to help you establish a sleep routine from the morning to night. During your waking hours, a dawn simulator helps you get out of bed and start your day. And at night, the device has a soft light to help you read and relax before bed or you can listen to soothing, meditative sounds to gently lull yourself to sleep.

Another way to reset your circadian rhythms is to establish and maintain a routine, says Rohan. Maintain a sense of normalcy as much as possible by following a schedule. Get up. Shower. Get dressed. Make your meals at the times that you usually do, she advises. Maintaining a schedule in this way can help regulate the circadian clock.

Keeping a daily planner, for example, might help you establish a schedule and hold yourself accountable for sticking with it.

Panda Planner Pro Daily Planner

Rohan also notes that its important to make time to do a hobby or something that you can enjoy.

This is really important for mental health because theres a very strong relationship between doing fun things and mood, Rohan says. She recommends finding simple pleasures that you can enjoy inside like playing a game or reading a book.

In addition to light, Rosenthal adds that stress also has a major impact on feeling down in the winter.

Add stress to the equation, and you will bring out the symptoms, Rosenthal says. As COVID-19 continues to affect so many lives and communities, stress and anxiety may feel inescapable this winter. And individuals who struggle with seasonal affective disorder are particularly sensitive to life events.

I think its the perfect storm because, by definition, their issue is recurrent depression, Rohan says. And then you couple that with a global pandemic, anxiety and very real issues that are associated with that uncertainty over jobs, finances, health, themselves and other people, and familyits kind of a double whammy.

Exercise

Rohan and Rosenthal recommended one easy stress-reliever that anyone can do at home: exercise.

Exercises are a wonderful way to decrease stress and so is meditation, Rosenthal says. Whether youre doing an hour-long workout or a quick 15-minute session, here are some home-workouts for a long and socially distant winter, recommended by fitness experts.

Skipping rope or using non-slip resistance bands are an excellent way to get some quick movement and keep the cabin fever at bay.

Yoga and meditation

Rosenthal also recommended yoga and meditation as a way to fight stress and find serenity during these turbulent times. So hit the mat for several sun salutations every day or if youre new to yoga and are looking for a guided practice, a monthly membership with Glo will fit your meditation and yoga needs. Additionally, if you need a comfortable way to move on the floor, Ewedoos has a great, eco-friendly yoga mat.

Read More: The Best At-Home Workouts for a Long and Socially-Distant Winter, According to Fitness Experts

If youre familiar with the winter blues, you may know people who swear by taking a daily dose of vitamin D. With less exposure to the sun, many have equated their seasonal mood swings to a deficiency in the essential vitamin. However, theres not a lot of data that shows that vitamin D improves mood.

There is surprisingly little research on vitamin D and seasonal affective disorder. And most of them have a teeny tiny sample size, Rohan says.

Most people in the U.S. have insufficient levels of vitamin D. Interestingly, researchers have noted that the groups who are at risk for vitamin D deficiency are also groups that are at risk of suffering from major depressive disorders. Rosenthal believes its the placebo effect of taking natural supplements and feeling healthy that lifts our spirits. While there may not be evidence of its efficacy as a mood booster, he says it cant hurt to take a supplement.

A lot of these vitamins may have a placebo, Rosenthal says. But, I wouldnt discount it if somethings making you feel better. It certainly shouldnt hurt you in the long run. If you do decide to take some supplements, Rosenthal recommends having your physician monitor your levels and intake. Vitamin D supplements are relatively inexpensive and available on Amazon.

Some self-help for the winter blues is necessary, especially during a time when mental health professionals are in high demand due to anxiety around the pandemic. However, Rohan stresses that you should seek out help if you are struggling to get your depression under control.

There are psychiatrists, psychologists, community health and mental health workers who are prepared to recommend an effective treatment because seasonal depression is very treatable, Rohan says.

Like many other major depressive disorders, antidepressant medications that require a prescription from a physician are proven to help treat SAD. Rohan has found that certain methods of cognitive-behavioral talk therapy can be extremely effective in treating SAD, a field that she herself has developed and studied.

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Winter Got You Down? Here's How to Combat Seasonal Blues, According to Experts - TIME

Dec. 22The coronavirus has so far killed about 325,000 people in this country, but that staggering toll does not include the multitudes who have died because of disruptions, isolation, and destitution related to the pandemic.

People with diabetes or Alzheimer's disease are particularly vulnerable.

An Inquirer analysis of federal data found that from mid-March through November, Pennsylvania had 753 more deaths attributed to Alzheimer's and diabetes than would be expected based on the last four years, a 14% increase for each cause. In New Jersey, there were 634 more deaths than expected for the two causes, an increase of 11% for Alzheimer's and 33% for diabetes.

The same trends occurred across the country, according to the Inquirer analysis, which aligns with other studies this year of "excess deaths" the gap between actual and expected deaths. The biggest deviation from the norm for Alzheimer's and diabetes was in April, but every month had excess deaths attributed to these causes.

Even in the best of times, diabetes can be a costly, complex, frustrating condition to manage. Sugar builds up in the blood, either because the body can't properly use or doesn't make enough insulin, the hormone that regulates sugar. If not controlled with diet, exercise, and often, medication, diabetes can cause devastating complications including heart disease, blindness, kidney failure, and lower-extremity amputations. Diabetes is the seventh leading cause of death in the United States.

Because Type 2 diabetes, the most common type, is closely linked to obesity, incidence has been soaring over the last decade. About 34 million American adults and children just over one in 10 have diabetes, and 88 million more adults about one in three have higher than normal blood sugar, called prediabetes.

Barbara Simon, an endocrinologist at Thomas Jefferson University Hospital, sees "multiple layers and multiple factors" related to the pandemic eroding the health and welfare of her diabetes patients.

"From my experience, the No. 1 issue is economic stress," she said. "Many are out of work and not able to afford their already expensive medicines."

Even the price of insulin, a decades-old generic drug, has increased dramatically over the last decade. (For those with Medicare, some Part D plans will cap the monthly copay for insulin at $35 beginning in January.)

"Studies have shown that prior to the COVID pandemic, up to 25% of insulin-dependent diabetics rationed supplies to save money," area physician Jennifer N. Goldstein wrote in September in The Inquirer. "The dramatic rise in unemployment and the loss of employer-sponsored health insurance due to the COVID-19 pandemic is likely to bring this crisis to a breaking point. This is particularly true in Pennsylvania, where unemployment rates hover around 13%, and almost 700,000 residents are uninsured."

As the U.S. Postal Service has struggled with pandemic-related turmoil including historic volumes of mail and funding gaps lost and late mail has been an issue for people ordering diabetes medication or blood sugar test strips. In June, when Cherry Hill resident Gerald Katz went to his local post office to ask what happened to his box of strips, he was told, "Well, we can't find out."

At the same time, the civil unrest and vandalism that led some Philadelphia pharmacies to shut down for weeks in the spring left many patients struggling to get their medications, said Simon at Jefferson.

People with diabetes are at elevated risk of severe COVID-19 if they get infected. But the isolation of staying home to avoid the virus also has dangers.

"Patients who used to go to the gym can't anymore," Simon said. "So they are more sedentary. Their eating habits have also changed. A lot of my patients report weight gains."

"Patients are also unsure about coming in for medical care, perhaps because of fear of traveling or overburdening the medical system," Simon added. "We try to assure them that diabetes is one of the diseases we can address well with telemedicine."

Lisa Walke, chief of geriatrics at the University of Pennsylvania's Perelman School of Medicine, said people with diabetes face a double whammy as the pandemic complicates their lives.

"Stress causes your sugars to be less well-controlled and, obviously, this has been a stressful time," Walke said.

It is possible that some of the excess deaths of Alzheimer's patients were actually due to undiagnosed COVID-19, experts said. Particularly in the early months, testing was not widespread in nursing homes, where many with advanced dementia live, and people without obvious symptoms may have been overlooked. Moreover, people with dementia were probably less likely than others to talk about feeling sick.

Walke, at Penn, said COVID-19 cases among frail dementia patients who live in the community are probably still being underdiagnosed. These patients may find it difficult to access testing, or may not be strong enough to wait in line.

Another possible factor behind the excess deaths: some Alzheimer's patients could not withstand the social isolation and changes in their routines that were meant to protect them from the virus.

"Routine is an Alzheimer's patient's best friend," said Carol Lippa, director of the Cognitive Disorders and Comprehensive Alzheimer's Disease Center at Jefferson University Hospitals. "They do better when they know what to expect."

Patients in facilities were suddenly surrounded by staff wearing masks, gowns, and face shields. People with dementia "don't have the capacity to understand that, and that's just stressful," Lippa said.

At the same time, family members have been prohibited from visiting, cutting off the interactions that mean the most. That compounds the effects of isolation. "The quality of interactions is not as good," Lippa said. "It's not with the people who love them and are familiar with them."

Walke and Lippa said dementia patients in the community also have felt their worlds shrink and change in harmful ways.

Maybe they couldn't go to adult day care or church or take their daily walk. Visiting their doctors and getting home care has been more difficult. If dementia patients needed hospitalization for an illness other than COVID-19, many hospitals still don't allow family visitors. Penn has changed that policy for dementia patients, Walke said, not only because they need loving contacts, but also because they need advocates who can communicate for them.

(c)2020 The Philadelphia Inquirer

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Pune, India, Dec. 21, 2020 (GLOBE NEWSWIRE) -- The global womens health market size is projected to reach USD 41.05 billion by 2027, exhibiting a CAGR of 3.2% during the forecast period. The COVID-19 pandemic is likely to reemphasize the importance of woman health and boost the market, observes Fortune Business Insights in its report. The infection caused by the coronavirus, which has affected more men than women across the globe, has brought the issue of health of women in the spotlight. A UN policy brief released in April 2020 stated that women hold less secure jobs and earn lower wages, which makes them highly vulnerable to the adverse effects of this pandemic. More importantly, as the pandemic intensifies, womens health will inevitably suffer.

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Increasing Prevalence of Women-centric Diseases to Aid Growth

A leading factor aiding the womens health market growth is the rising incidence of women-specific diseases and disorders around the globe. For example, the 2018 GLOBOCAN report by the International Agency for Research on Cancer (IARC) revealed that female breast cancer diagnoses stood at 2.1 million in 2018, accounting for approximately 11.6% of the total global cancer burden.

Further, female breast cancer was the fifth leading cause of death, contributing to 6.6% of the total global deaths in 2018. Another prime example is osteoporosis in women, a disease that generally afflicts menopausal women, causing reduction in bone density. The National Osteoporosis Foundation, for example, estimates that 20% of Caucasian women aged 50 and above have osteoporosis.

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As a result of their complex internal body dynamics, management of womens health, especially post-pregnancy and post-menopause, when hormone imbalances are known to occur, requires high level of efficiency and accuracy. Products designed to facilitate effective management of women-centric diseases will, thus, play a crucial in augmenting this market in the forthcoming years.

Robust Spending on Womens Healthcare to Stoke Market Growth in North America

North America is expected to emerge as a major revenue generator for this market during the forecast period, having registered a market size of USD 18.00 billion in 2019. The primary reason for the regions dominance in the market share is the large amount of funds allocated to enhance womens healthcare across the US and Canada. This is a result of the spreading awareness about health issues and the growing prevalence of women-specific diseases in the region.

Improving healthcare infrastructure, especially in Eastern European countries, is anticipated to bolster Europes position as the second-largest region in this market. Asia Pacific is expected to grow at the highest CAGR on account of the rising awareness about the importance women health.

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Launch of Digital Health Solutions for Women to Fuel Innovation

Some of the leading players in this market that specialize in female wellness and health are coming out with path-breaking digital solutions to address the unique health issues faced by women. These solutions are aimed at enabling women to take care of their independently without affecting their daily routines.

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Women's Health Market to Touch USD 41.05 Billion at 3.2% CAGR by 2027; Growing Focus on Women's Health Worldwide to Positively Impact the Market:...

How to Find the Best CBD Gummies

When it comes to choosing the best CBD Gummies, thorough research of reputable brands and every ingredient, extracting method, and recommended dosage will undoubtedly help ensure you get precisely what you hope and pay for. Its main ingredient is cannabidiol or CBD, the most active cannabinoid in hemp plants that carries many health benefits for users.

Many health enthusiasts see CBD as a holistic health supplement. Its popularity is in part because while it is derived from a cannabis plant, it has no intoxicating side effect, unlike its sister-cannabinoid, tetrahydrocannabinol THC. You can also find it in various forms, including CBD oil tinctures, capsules, flowers, topicals, vapes, and a lot more.

If youre thinking about dipping your toes into the world of cannabis but are hesitant about the infamous marijuana high, try out hemp-derived products instead. Most of which are low in THC and wont have any undesired side effects if taken correctly. CBD gummies are a great start; they taste delicious and dont look so daunting as other products.

There are various things to look for when shopping for the best CBD gummies. Of course, it is important to always know more about a product before purchasing it and using it for yourself. Cannabidiol has been named a generally safe substance by the World Health Organization because of its lack of potential abuse and dependency.

Due to the influx of hemp products in the market recently, not everything undergoes the Food and Drug Administration (FDA). As demands go up, so does the supply, but you have to be careful not to fall into the trap of CBD oil brands selling themselves as the panacea for everyone.

Each type of CBD product is unique and can serve you differently if you know which ones to look for. Listed below are some factors to consider before making any major purchase and incorporating the cannabinoid into your daily health routine.

Not all hemp CBD products are made the same. Most use CBD oil to infuse gummies, pills, or topicals, but these extracts are also categorized into three main types: full-spectrum , broad-spectrum CBD, or CBD isolate. The first two contain many cannabinoids, with the full-spectrum containing a meager amount of THC while the broad-spectrum stays THC-free.

Isolates are potent, coming up to around 99% of pure CBD. This one is usually the most expensive out of the three because it is more challenging to produce. Full-spectrum CBD gummies are taken by those who want to experience the entourage effect. The legal limit of 0.3 percent THC by dry weight is still observed, so no worries about any psychoactive side effects.

The entourage effect gives users the benefit of enjoying the other compounds present in the raw plant material and formula, such as terpenes, flavonoids, and other cannabinoids like CBC, CBG, and CBN. Some studies suggest that using CBD and hemp extracts with these other compounds makes the cannabinoid even more effective and long-lasting.

No matter the type of hemp oil extract, the best CBD gummies or a gummy bear are always the ones you prefer. Try out all of the above by asking your local hemp store if they sell trial size products, and see which ones serve you best.

Try looking up best CBD gummies on search engine platforms, and you will usually be linked to websites of reputable cannabis or organic hemp brands. These companies pride themselves in producing the best quality of cannabidiol in the market, with impeccable customer service, and some of their buyers might be inclined to agree.

If you head on over to their product page, try and look for a section that states the CBD oil has undergone third-party laboratory testing. It is even better if there is a link to the result of said testing somewhere on the site. These tests are done by an accredited laboratory not associated with the brand for an unbiased review of the products potency and efficiency.

Third-party lab test results also make sure you are getting CBD gummies safe from unwanted chemicals, pesticides, chemical fertilizers, and toxins. The test report also states the methods used in extracting the hemp oil extract, such as Supercritical CO2 Extraction Method. This one is considered the safest standard of extraction in the industry producing high quality cannabidiol for each product.

The hemp and CBD market can be confusing, so be sure to ask questions first and purchase later. Companies or independent labs that refuse to disclose such valuable information to their customers are not worth spending a dime on, so be careful in researching a brands background and business ethics.

Most manufacturers and avid users would agree that the secret to making the best CBD gummy packs is organically home-grown hemp of the highest quality. As the raw plant material where the oil is extracted, it is important that the hemp planted, cultivated, and harvested is done using safe and sustainable farming methods.

Not only that, but all subsequent ingredients must also be as organic, GMO-free, and vegan-friendly as possible. Premium companies help hemp farmers in breeding and harvesting the best quality of raw hemp to be used in their full-spectrum and broad-spectrum CBD gummies. This practice also boosts the local farming communities income and employment rate.

In addition to this, reputable brands always put every ingredient on their labels. These labels should always be true to the products composition, and the only way to ensure this is to be vigilant at the ingredients listed therein. Youll want your gummies to contain only natural flavorings and sweeteners made possible by infusing them with real fruit juice extracts.

One hemp brand, BlosumCBD, promises all of the aforementioned good qualities and best values listed above. Blosum CBD products are made from locally and organically-grown hemp, the cannabidiol extracted using the safest and most meticulous methods, mixed only with compounds that would enhance CBDs health benefits, undergone third-party lab testing, and packed securely.

This CBD brand also offers great deals to customers and offers discounts, sales, and free shipping within the United States with a minimum amount of purchase. Depending on your preference, Blosum does not only provide the best CBD gummies but have varying products available as well. These include their flavored oil tinctures, softgels, topicals, and pet treats.

CBD Gummies Vegan Full-Spectrum

Price: Starting at $74.99

Strength: 10 mg or 25 mg of CBD

Flavor: Mixed Fruit (Watermelon, Orange, and Strawberry)

BlosumCBDs Vegan Full-spectrum Gummies have it all! These all-natural ingredient treats are not only delicious but beneficial for a better quality of life. Each of these full-spectrum gummies contains 0.3% THC, meaning you can get the full effects of benefits like the entourage effect from the high potency level. Blosums Vegan Full-Spectrum Gummies are:

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CBD Gummies Vegan Broad-Spectrum

Price: $74.99

Strength: 25 mg of CBD

Flavor: Strawberry

If youre looking for a great gift for beginners using CBD or are just hesitant on THC, look no further than BlosumCBDs Vegan Broad-Spectrum Gummies! This 25 mg gummy is gluten-free as well as being vegan. Each of these broad-spectrum chewy treats contains zero THC, meaning you can still get the full effects of benefits like the entourage effect without the worry of consuming any THC remnants. Blosums Vegan Broad-Spectrum Gummies are:

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Much like other CBD products, CBD gummies work by having the body absorb the cannabidiol compound and work with the endocannabinoid system or ECS. The ECS is responsible for maintaining an overall balance in the body that regulates your mood, pain receptors, sleep cycle, stress levels, hormone production, and other vital processes needed to keep healthy.

When orally ingested via an edible like gummies, CBD is deposited into the bloodstream and distributed throughout the body through your natural cannabinoid receptors. It may help with many seemingly inconsequential but occurring conditions in your body, such as backaches, inflammation, migraines, difficulty sleeping, and anxiety symptoms.

There are several ways to take CBD edibles, as you may be well-informed by now. As mentioned before, CBD is considered a generally safe substance as there has been no recorded overdose on the compound to date. However, it is important to note that there is no universal dosage for any hemp product, including CBD gummies.

On average, users take one to two of the soft candies per dose, sometimes up to three times a day. This does not mean that you need to go dose it up this high, especially if it is your first time introducing the cannabinoid into your system. There are other factors to consider when doing the dosing guesswork, including your body mass and the products bioavailability.

The amount of CBD in each gummy could also affect how your body will metabolize the compound, along with its other ingredients. Different studies suggest varying dosages but listen to how your body reacts and work from there at the end of the day. Increase or decrease intake according to your desired effect.

Although it may take longer even for the best CBD gummy candy to start working, stay consistent in your product. Stay with a routine for at least 4-6 weeks. Compared to oil tinctures taken via sublingual absorption, gummies need to be digested so their absorption will be gradual. Take one gummy for your first dose and see how long it takes to take effect.

Most hemp products are relatively new to the market. Admittedly, even the science behind cannabis side effects and health benefits are fairly new and young in theory at best. There has been substantial evidence regarding CBDs anti-inflammatory, antibacterial, and antioxidant properties, but these still need a wider test audience and clinical trials.

This resulted from the decades-long cannabis ban worldwide that put a screeching halt to many scientific studies on the plant and its great potential. It is only recently that policymakers have started listening to their constituents and health experts that hemp, marijuana, and its many cannabinoids contain many modern medicine possibilities.

Now, CBD is used to help treat many conditions such as chronic pain, anxiety, and stress symptoms, sleeping difficulties, skin problems, among many others. In a more controlled space, hemp and CBD have also been used and are currently being used to help treat the symptoms of

long-term conditions like Dravet syndrome, certain types of cancer, and multiple sclerosis.

With the passage of the 2018 Farm Bill, industrial hemp was declared legal on a federal level. This comes with a restriction that no product must contain more than 0.3% THC by dry weight to be allowed for manufacturing and distribution to local stores and groceries. The hemp industry was also handed over to the jurisdiction of the Department of Agriculture and the FDA.

While federally legal, some states still abide by their strict medical marijuana programs. They prohibit any cannabis-derived products open use unless they have qualifying conditions that need the plants benefits for treatment and medicine.

Additionally, the FDA added its own set of safety nets that both hemp sellers and consumers should keep in mind. These included being aware that no CBD product in existence has been approved nor evaluated by the FDA, and any brand claiming so is playing their customers false. No hemp product is also intended to treat, cure, or diagnose any medical condition.

If you are thinking of adding the best CBD gummies to your wellness routine, it may very well be the best thing you do, considering its many wondrous health benefits. Gummies are a delicious and discreet way of trying out CBD and seeing if it agrees with you. You can take them anywhere, eat them at any time of the day, and not worry about any harsh side effects.

CBD oil is also a good, long-term supplement that is organic and all-natural. It could help maintain homeostasis in the body, give your immune system a good boost, and help with any discomforts you may be currently experiencing. The added support to the body could do you wonders, but only if you take heed of the information and tips listed above.

Be sure to inform your attending physician first before making any significant changes to your diet and health routines. Pregnant, nursing, or people with complicated medical histories may react to CBD. Cannabidiol gummies may not be for everyone but try them to find out for yourself.

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How to Find the Best CBD Gummies - Cincinnati CityBeat