Archive for October, 2021

Its nice [being back on campus] because now that we know what its like to leave, it makes being back all that more special, Becca Bucholz (COM20) (not pictured) said on Sunday. Photo by Jackie Ricciardi

COMMENCEMENTSpeaker Victor J. Dzau (Hon.20), National Academy of Medicine president: Apathy is a luxury we simply can no longer afford

Nearly a year and a half after receiving their diplomas, Boston Universitys Class of 2020 finally donned their scarlet caps and gowns and were honored for their four years of work and studyingthe COVID-postponed 147th Commencement was held on Nickerson Field Sunday afternoon.

COVID robbed you of a traditional senior year, speaker Victor J. Dzau (Hon.20), president of the National Academy of Medicine, said in his Commencement address to the 1,818 Class of 2020 graduates who returned to campus for the long-awaited ceremony. They traveled from 46 states and represented 61 countries. You have already demonstrated incredible resilience and fortitude, Dzau said. You have prevailed and are here today with each other.

Of the 6.2 billion doses of COVID vaccines administered worldwide, just 2 percent of people in low-income countries have been vaccinatedthats unacceptable Victor J. Dzau (Hon.20) said to applause. We cant end this pandemic anywhere until we end it everywhere. Video by BU Productions. Photo by Melissa Ostrow

He noted that an atypical ceremonycoming as it did in October, not Maywas fitting for the Class of 2020 since there is nothing typical about them. Their childhood was marked by 9/11, their adolescence defined by the 2008 global financial crisis, and now they enter adulthood during the greatest public health emergency in over a century. There will be even more crises and setbacks, Dzau said, and while painful, they can also present opportunities. If we can view adversity in this wayas a chance to learn, to grow, and to emerge stronger and wiser than we ever thought possiblethen we can face the future with confidence, he told the approximately 7,500 grads and guests on Nickerson.

Dzaus pioneering research in cardiovascular medicine is credited with helping millions around the world live longer, better lives. As a child he and his family fled communism in his home country of China during its civil war, and moved to Montreal. His research in cardiovascular medicine led to the development of lifesaving ACE inhibitors that treat hypertension and congestive heart failure and pioneered gene therapy for vascular disease. Now, as president of the National Academy of Medicine, he works to create a global system of quality, affordable healthcare and leads the academys response to COVID.

He shared what hes learned, sprinkled with anecdotes from his own life: keep going, find your purpose in life, surround yourself with people who help you persevere (and be sure to return the favor), and keep caring about, and improving, the world.

Growing up an immigrant and a refugee, Dzau said, he saw firsthand instances of injustice, discrimination, and suffering, and he noted that the current pandemic has led to more of the same, specifically regarding access to COVID-19 vaccines. Of the 6.2 billion doses of COVID vaccines administered worldwide, just 2 percent of people in low-income countries have been vaccinatedthats unacceptable, he said to applause. We cant end this pandemic anywhere until we end it everywhere. If we allow variants of the virus to keep emerging and spreading, we may even end up in a situation where the vaccines dont protect us anymore.

The National Academy of Medicine is working closely with the Global Preparedness Monitoring Board (COVAX), the global immunization program, and national leaders, including the Biden administration, to ensure equitable access to COVID vaccines, treatment, and testing. Apathy is a luxury we simply can no longer afford, especially when we face big global challenges such as pandemics and climate change, Dzau said. We have to cooperate with each otherin our communities and across borders. We have to keep caring.

It was a busy weekend on campusin addition to Sundays All-University Commencement, individual schools and colleges held Class of 2020 recognition events (called convocations in past years), where the now-alumni had the traditional experience of hearing their names called and walking across the stage. The class also mingled with lots of fellow alums, as the University hosted its annual Alumni Weekend as well.

While the Class of 2020 received a virtual send-off in May 2020, when the state of the pandemic made large, in-person gatherings impossible, it wasnt a substitute for the real thing. It may have taken 17 months, but it is a pleasure to welcome to Nickerson Field the members of the Class of 2020 and your guests; you told us you wanted to return to campus, and you did, BU President Robert A. Brown said in his greeting. Your senior year was interrupted like no other, you were forced to move off campus and adapt to Zoom learning You then moved on to your careers, all with COVID-19 raging. I could not be more proud of youthere has never been a class more deserving of a Commencement.

Although COVID-19 restrictions were more relaxed than for last Mays Class of 2021 Commencement, University officials requested attendees be vaccinated and required masks be worn during indoor events. But many chose to wear masks on Nickerson Field, too. And unlike the 2021 graduation, where no guests were allowed, the Class of 2020 could have four guests.

For the first time in BU history, the Commencement student speakerMacken Murphy (CAS20)was an alum. It might feel, for many of you, that the sunset of your education was taken from you; I know none of you expected to graduate late from an online university, he joked, going on to say that his classmates time in school taught them how to become better citizens. Yes, we worked on our math and writing; we also reflected on our morals and values. Yes, we studied science; we also discovered the importance of service. Of course, we studied historywe also learned that we are living in it. Now, at last, it is time to concentrate on worthy goals, display our intelligence, and prove our character.

Following his address, Dzau received an honorary Doctor of Science from Brown. Also receiving honorary degrees were Thomas R. Insel (CAS72, MED74), former director of the National Institute of Mental Health, Doctor of Science; David Satcher, 16th US Surgeon General, former Secretary for Health in the Department of Health and Human Services, and former director of the Centers for Disease Control and Prevention, Doctor of Laws; and Mark Volpe, who recently stepped down as president and CEO of the Boston Symphony Orchestra, Doctor of Humane Letters.

Also honored were the winners of the 2020 Metcalf Cup and Prize and Metcalf Awards for Excellence in Teaching, the Universitys highest teaching awards. The Metcalf Cup and Prize went to Sarah Sherman-Stokes, a School of Law clinical associate professor of law, who is credited with helping make LAWs Immigrants Rights & Human Trafficking Program nationally recognized. Seth Blumenthal (GRS13), a College of Arts & Sciences Writing Program senior lecturer, and Courtney Goto, a School of Theology associate professor of religious education, were the recipients of the Metcalf Awards.

I think were all really excited to finally be having this moment of closure and to reunite with our friends, since a lot of us moved out of Boston, Kylie Umehira (COM20) said on her way into Nickerson Field.

Were reliving some of our glory days, added her friend Becca Bucholz (COM20). It had been a full year since the friends had been able to spend time together, so after the ceremony, they had a fancy dinner and champagne planned. A lot of us are working, so its nice to pretend that were back as students, she said. Its nice because now that we know what its like to leave, it makes being back all that more special.

Alene Bouranova contributed reporting to this story.

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Class of 2020 Gets Long-Awaited Send-off | BU Today - BU Today

An extensive research report on the Hormone Replacement Therapy Market envisaged diligently by MarketResearch.Biz comprises a 360-degree view of the present market situation as well as its future growth survey. This report will offer you all the accurate data related to the different market bifurcations covering a crystal-clear idea on the Hormone Replacement Therapy market. In addition, we are literally promising you to give the perfect information on the distinct marketing angles and status over the upcoming duration of 2021-2030. There are some of the most important marketing aspects that are adequately boosting the growth of the worldwide market. They are gross margins, market penetrations, CAGR study, Porters 5 Force Model, descriptive and well-defined graphical representations, business strategies, etc.

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Competitive Landscape with Key players:

Abbott Laboratories, Novartis, Pfizer Inc, Mylan Laboratories, Merck and Co, Novo Nordisk, Bayer Healthcare, Eli Lilly, Genentech

Hormone Replacement Therapy Market Taxonomy

Segmentation by Product: Estrogen Hormone Replacement Therapy, Human Growth Hormone Replacement Therapy, Thyroid Hormone Replacement Therapy, Testosterone Hormone Replacement Therapy.

Segmentation by Route of Administration: Oral, Parenteral, Transdermal, Others.

Segmentation by Type of Disease: Menopause, Hypothyroidism, Male Hypogonadism, Growth Hormone Deficiency, Others.

Regional Outlook: The Hormone Replacement Therapy Market

The current study analyzes the Hormone Replacement Therapy Market thoroughly. Research is also conducted for Russia, China, the United States, Taiwan, Germany, the United Kingdom, Italy, Japan, South Korea, Canada, France, Mexico, and Southeast Asia. It is expected that North America, Europe, Asia-Pacific, Latin America, and the rest of the world have the largest prudence in the Hormone Replacement Therapy market world.

Among other things, this report calculates factors that contribute to regional growth, such as the environment, Hormone Replacement Therapy market economic progress, and social factors. In the analysis, regional production records, revenue information, and manufacturer data were studied globally. Revenue and volume projection consider regional differences.

This report offers understanding into the accompanying variables:

Understanding Business Sector Development: This research provides a far-reaching outlook of the items provided by the top influencing players in the global Hormone Replacement Therapy market.

Advancement of new items: Reports anatomize the most latest innovative turns of events, innovative business strategies, and item dispatches.

Evaluating the cutthroat scene: Comprehensive investigation of market systems, geographic introduction, and item fragments of the markets prominent players.

Advancement of new business sectors: An cumulative manual for developing business sectors. Various areas are inspected across topographies in this report.

Market Expansion: The complete overview of progress and interests in the worldwide Hormone Replacement Therapy market, like new items, undiscovered topographies, and current patterns.

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Significant incorporation in the Hormone Replacement Therapy market report:

Impacts of the Covid 19 on progress status, temporarily and long haul.

A portion of the business crucial patterns.

Income, volume, and deals insights are included in this report.

Mentioned development possibilities.

Market and submarket development estimations.

Roundabout and direct deals channels: positives and negatives.

Hormone Replacement Therapy market sellers, dealers, and merchants are on the top of the list.

The labor force size and rebuild spaces of each organization are crucial subtleties.

Items and administrations are provided by the important players on the lookout.

Data from each organization in regard to its calculating model, deals volumes, net income, working interest, and a portion of the complete industry.

Itemized information on showcasing strategies, highlight the market, commercialization rates, just as other business-related information.

Table of Content

Section 1: Global Hormone Replacement Therapy Industry Outlook

Section 2: Global Economic Effect on Hormone Replacement Therapy Industry

Section 3: Global Market Competition by Industry Key Players

Section 4: Global Productions, Revenue (Value), with respect to the Regions

Section 5: Global Supplies (Production), Consumption, Export, Import, globally

Section 6: Global Productions, Revenue (Value), Current Trend, Price, Product Type

Section 7: Global Market Study, on the basis of Application

Section 8: Hormone Replacement Therapy Market Pricing Study

Section 9: Market Chain Analysis, Sourcing Strategy, and Downstream Buyers

Section 10: Business strategies and vital policies by Distributors/Suppliers/Traders

Section 11: Key Marketing Strategy Study, by Key Vendors

Section 12: Market Growth Driver Analysis and Their Impact Study

Section 13: Global Hormone Replacement Therapy Market Forecast

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Hormone Replacement Therapy Market Rise in Sustainability Around The World 2021 2030 - Taiwan News

Choosing The Right Supplement Will Help You Boost Your Testosterone With No Side Effects

The hormone which is called testosterone is produced naturally in the testicles of men and ovaries of women. For men, it plays an important role in the development of make male growth and bringing in masculine characters. As for women, it is produced in smaller amounts. During the adolescent years, this hormone is produced at its best level all the way until early adulthood. Once you reach the age of 30 and above, this natural hormone starts to drop slightly each year.

While in the younger years, these hormones help to develop facial hair, deeper voice, and overall all growth development, in the years after 30, the drop in this hormone can inhibit the quality of life. To stabilize the natural growth of this hormone, people often choose supplements that are the closest thing to steroids and are naturally safe as well. This helps them to regain muscle mass and improve bone density. It allows them to enjoy a healthy sex drive and also helps to alleviate their mood. The verbal memory and thinking ability are also enhanced with the balance of this hormone.

Before you start looking for a booster, your first step should be to get examined properly by a doctor. The natural effects of low testosterone are generally decreased muscle mass, weight gain, and other conditions. However, sometimes there can be other underlying medical conditions that could be having the same symptoms. If your doctor does indeed state after the tests that you have low levels of t-hormones or hypogonadism, then you can proceed towards purchasing a supplement for the same.

A t-hormone or testosterone hormone booster can help you to benefit in many ways. However, the most crucial part of it is to buy the right one that does not cause any negative side effects. Most people prefer to buy it online as it saves them both time and money. To make sure you buy the right one you must do your due research. This will ensure that you have bought the right supplement and the ingredients are of good quality. Below are 6 things to look for when buying the testosterone booster.

When it comes to buying such supplements, there are a galore of products to choose from. This can be confusing. When you want to have the best over-the-counter testosterone booster, start by ensuring that the seller and manufacturer are indeed legitimate. This ensures that the product that you receive is of superior quality and will benefit you from its use. Research a bit on the company to see if they have been long enough in the market so that their brand is well known. Most of these drugs have a shelf life of 5 years, so if the company has been around that long as well, then it is legit. Another way to see if the company is genuine, check if they have a money-back guarantee. This claim can only be made by companies that are confident about their product so that they will not sell any low-quality ingredients. Furthermore, if the supplement does not work for you, you will get a refund.

When you are looking to buy supplements, you will need to give a closer look at all the ingredients present in them. These should be more on the natural side and of high quality. With the right ingredients and quality, you will be able to get faster and better muscle recovery. There are many ingredients that you can cross-check to see if they are scientifically proven to boost testosterone levels. These ingredients generally are fenugreek, ginseng, zinc, Vitamin D3, and so on.

When buying a booster online or from a shop, you need to ensure that the dosage is right for you. Sometimes taking a higher dosage can have more effective results but at the same time can bring in higher risks of getting the side effects. So make sure the dosage is right before investing in a supplement. You can take medical advice or that of your gym instructor to help you understand what dosage is right for you.

Reviews are helpful for all sorts of purchases of goods or services. It allows you to understand how other people with similar problems like yours, felt about their experience with a particular product or service. The same principle can be used when buying supplements. You can check other consumer reviews to see what the experience of other people has been and then make a decision if they will be effective for you as well. Of course, boosters with more positive reviews are the ones that you should go for.

While reading the positive reviews is a good idea, if there are any negative testimonials, then you should read that too. If there are quite a few negative testimonies then it will be better to refrain from the supplement. This way you will not spend your hard-earned money on something that does not seem to work.

Firstly, you should look for supplements that have no side effects but there are chances that while buying one, you will end up taking one that has some potential side effects. This could be because there would be some harmful ingredients that can have negative side effects so check it properly before use. Also, check with your doctor what are the expected side effects that you can expect so that you are more prepared.

The above points must be kept in mind when you want to find the right product. A reputable seller who is offering the products at competitive prices and has good reviews to show should be your first choice. Compare a few supplements against each other and look for something that has the best potency. Simultaneously, you can also try some natural ways by eating the right food vitamins, and herbs to help you improve your testosterone level. After all, when it comes to your health, you want to put your best foot forward.

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6 Things To Look for In a Good Testosterone Booster Supplement - The Portugal News

This article was originally published here

Curr Oncol. 2021 Aug 28;28(5):3331-3346. doi: 10.3390/curroncol28050289.

ABSTRACT

Androgen deprivation therapy (ADT) is successfully used in patients with advanced prostatic cancer, but there are many concerns about its systemic side effects, especially due to advanced age and frequent comorbidities in most patients. In patients treated with ADT there are metabolic changes involving the glycaemic control and lipid metabolism, increased thrombotic risk, an increased risk of myocardial infarction, severe arrhythmia and sudden cardiac death. Still, these adverse effects can be also due to the subsequent hypogonadism. Men with heart failure or coronary artery disease have a lower level of serum testosterone than normal men of the same age, and hypogonadism is related to higher cardiovascular mortality. Many clinical studies compared the cardiovascular effects of hypogonadism post orchiectomy or radiotherapy with those of ADT but their results are controversial. However, current data suggest that more intensive treatment of cardiovascular risk factors and closer cardiological follow-up of older patients under ADT might be beneficial. Our paper is a narrative review of the literature data in this field.

PMID:34590590 | DOI:10.3390/curroncol28050289

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Androgen Deprivation Therapy, Hypogonadism and Cardiovascular Toxicity in Men with Advanced Prostate Cancer - DocWire News

Superfood No 4: Tart cherry juice

Tart cherries have a high dietary melatonin concentration and have also been shown to exhibit anti-inflammatory characteristics that may be beneficial in improving sleep quality, explains Kristine Dilley, a registered dietitian at TheOhioState University Wexner Medical Center. One small Louisiana State University study found that drinking 8 ounces of tart cherry juice twice a day for two weeks increased both sleep time and sleep efficiency in adults with insomnia. Another study had 20 volunteers drink tart cherry juice or a placebo for seven days. Those who drank the cherry juice had significantly higher melatonin levels than those who didnt.

As tart cherry juice contains natural sugars, Dilley warns that individuals with diabetes or conditions that make them sensitive to sugar intake should consult their physician before adding this to their daily routine. And when purchasing, opt for brands without added sugars.

Chamomile tea has been used for decades as a sleep aid for its calming and antioxidant properties. It comes from a flower and is full of calming scents, says Dana Ellis Hunnes, adjunct assistant professor in the Department of Community Health Sciences at UCLA Fielding School of Public Health. Chamomile also contains apigenin, a flavonoid (plant nutrient) that promotes sleepiness, she adds.A recent study that examined the effect of chamomile extract on the sleep habits of adults age 60 and older found that when compared to the placebo group, those who drank chamomile had significantly improved sleep quality.

But this classic isnt the only type of herbal tea to try. Low-caffeine green tea contains theanine, an amino acid that research has found can help lower stress and significantly improve sleep quality. And teamade from the herb lemon balm contains naturally occurring oils with terpenes, organic compounds that can promote relaxation and better sleep, Hunnes says.

One study of Japanese men and women found that a high dietary glycemic index and high rice consumption was significantly associated with good sleep. The study also looked at bread, which was not associated with sleep quality and found that noodles were linked to poor sleep.

Dilley recommends brown rice, which is higher in fiber. In a study published in theJournal of Clinical Sleep Medicine,eating a higher fiber diet was associated with less nighttime awakenings and more restorative slow-wave sleep, she explains. This effect, she says, could be due to the fact that fiber helps prevent blood sugar spikes that may lower melatonin. Sylvia Melendez-Klinger,a registered dietitian and founder of Hispanic Food Communications, recommends trying a rice-dairy combo of rice pudding with no added sugar or rice crackers or rice cakes with a glass of warm milk, as another optimal bedtime snack.

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Superfoods to Help You Sleep - AARP

The FDA has granted fam-trastuzumab deruxtecan-nxki (T-DXd; Enhertu) breakthrough therapy designation for adult patients with unresectable or metastatic HER2-positive breast cancer who have received one or more HER2-targeting agents in prior lines of therapy, according to a press release from AstraZeneca.1

T-DXd demonstrated promising efficacy in this patient population in the phase 3 DESTINY-Breast03 trial (NCT03529110).2 The HER2-directed antibody drug conjugate yielded a 12-month progression-free survival (PFS) rate of 75.8% (95% CI, 69.8%-80.7%) compared with 34.1% (95% CI, 27.7%-40.5%) with ado-trastuzumab emtansine (T-DM1; Kadcyla). The median PFS was not reached in the T-DXd arm and was 6.8 months (95% CI, 5.6-8.2) in the T-DM1 arm.

The trial enrolled patients who had been diagnosed with unresectable or metastatic HER2-positive breast cancer and had been previously treated with trastuzumab (Herceptin) and a taxane in the advanced or metastatic setting. Additionally, patients were allowed to have clinically stable, treated brain metastases.

Patients were randomized 1:1 and were stratified based on hormone receptor status, prior treatment with pertuzumab (Perjeta), and history of visceral disease. The 2 treatment arms included a 5.4 mg/kg dose of T-DXd every 3 weeks (n = 261) or 3.6 mg of T-DM1 every 3 weeks (n = 263).

The primary end point of the study was PFS by blinded independent central review (BICR), with key secondary end points including overall response rate (ORR) by BICR, duration of response by BICR, investigator-assessed PFS, and safety.

Of the patients who were treated with T-DXd (n = 257), 132 are receiving ongoing treatment and 125 have discontinued due to death (n = 3), adverse effect (AE; n = 35), progressive disease (n = 66), clinical progression (n = 4), patient withdrawal (n = 13), or physician decision. Additionally, of the patients who were treated with T-DM1 (n = 261), 47 are receiving ongoing treatment and 214 have discontinued due to death (n = 3), AEs (n = 17), progressive disease (n = 158), clinical progression (n = 12), patient withdrawal (n = 11), or physician decision (n = 8). The median follow ups were 16.2 months and 15.3 months for the T-DXd and T-DM1 arms, respectively.

Additional findings from the trial indicated that patients in the T-DXd arm had an investigator-assessed median PFS of 76.3 months (95% CI, 22.1not evaluable [NE]) vs 7.2 months (95% CI, 6.8-8.3) reported in the T-DM1 arm (HR, 0.27; 95% CI, 0.20-0.35; P = 6.5 10-24). Additionally, the 12-month investigator-assessed PFS rates were76.3% (95% CI, 70.4%-81.2%) and 34.9% (95% CI, 28.8%-41.2%) in the T-DXd and T-DM1 arms, respectively.

Moreover, the median OS was NE for both treatment arms, and the 12-month OS rates were 94.1% (95% CI, 90.3%-96.4%) and 85.9% (95% CI, 80.9%-89.7%) in the T-DXd and T-DM1 arms, respectively (HR, 0.56; 95% CI, 0.36-0.86; P = .007172). Those who were treated with T-DXd had a confirmed ORR of 79.7%, including a complete response (CR) rate of 16.1% and partial response rate (PR) of 63.6%, compared with 34.2% in the T-DM1 cohort, including a CR rate of 8.7% and a PR rate of 25.5%.

The most common any-grade blood and lymphatic AEs were neutropenia (42.8%), anemia (30.4%), and leukopenia (30.0%) and common gastrointestinal toxicities included nausea (72.8%) and vomiting (44.0%). Moreover, the most common grade 3 or higher blood and lymphatic AEs included neutropenia (19.1%), thrombocytopenia (7.0%), and leukopenia (6.6%). Grade 3/4 gastrointestinal AEs included nausea (6.6%), vomiting (1.6%), and diarrhea (0.4%).

Originally posted here:
Trastuzumab Deruxtecan Granted Breakthrough Therapy Designation by FDA for Pretreated Unresectable/Metastatic HER2-Positive Breast Cancer - Cancer...

However, the study -- which published in the BMJ medical journal Wednesday -- did show a slightly increased risk of developing Alzheimer's disease, a specific form of dementia, among women who used estrogen-progestogen therapies for between five and nine years and for 10 years or longer. That translated into five and seven extra dementia cases, respectively, per 10,000 women.

"While the observational nature of the study means we can't be sure of knowing what causes what, I think the results here can still reassure us that these hormone therapies mostly aren't associated with increased risk of dementias," Kevin McConway, emeritus professor of applied statistics at The Open University in the UK, told the Science Media Centre in London. He wasn't involved in the research.

"And where there is some evidence of an increased risk, the increase isn't very big at all," he said.

Previous research into dementia and HRT has been inconsistent, the study noted. Lab studies and small trials have suggested a beneficial link between estrogen and age-related brain decline. However, a large trial of HRT, the Women's Health Initiative Memory Study, found an increased risk of developing dementia among users of estrogen-progestogen treatments, but these women were all elderly. And a Finnish study that published in 2019 flagged an increased risk of developing Alzheimer's disease among users of both estrogen-only and estrogen-progestogen treatments.

Using UK medical records, the researchers involved in the new study identified 118,501 women age 55 and over who were diagnosed with dementia between 1998 and 2020. A control group consisted of 497,416 women matched by age and by the same medical practice, who had no records for dementia.

Of the women with a dementia diagnosis, they found that 16,291 -- 14% -- had used HRT. The same percentage of women in the control group, or 68,726 of them, also used the treatment.

Not definitive

Also known as menopausal hormone therapy, HRT is used when women experience hot flashes, night sweats, insomnia and mood changes due to the disappearance of sex hormones called estrogen and progesterone. That happens as women approach menopause, typically in their late 40s or early 50s.

According to the study, overall there were no increased risks of developing dementia associated with menopausal hormone therapy "regardless of hormone type, application, dose, or duration of treatment."

Other risk factors, such as family history, smoking, alcohol consumption, pre-existing medical conditions and other prescribed drugs, were taken into account as part of the analysis. As an observational study, it can only show an association and is not definitive.

There are different types of HRT, and the type used depends on whether a woman has a uterus. Women who don't have one must use estrogen-only HRT. Those who haven't had a hysterectomy must use a combination of estrogen and progesterone to avoid thickening of the lining of the womb. Recently, replacements for progesterone have broadened choices for women.

Study author Yana Vinogradova, a senior research fellow at the department of primary care at the University of Nottingham, said the new research found only a small risk association between using combined HRT for long periods and development of Alzheimer's.

"Alzheimer's disease is a type of dementia which develops slowly, and some signs of it such as insomnia or memory loss are similar to menopausal symptoms," she said via email.

"The increased risk is very small and we also do not (and could not) claim that it was caused by MHT/HRT. It should not alarm users of MHT/HRT."

The study put the risk of dementia in context for doctors and their patients, wrote Pauline Maki, a professor in the University of Illinois at Chicago's department of psychiatry, psychology, and obstetrics & gynecology, and JoAnn Manson, a professor of medicine at Harvard Medical School and a physician at Brigham and Women's Hospital, in an editorial that accompanied the study.

"The primary indication for hormone therapy continues to be the treatment of vasomotor symptoms, and the current study should provide reassurance for women and their providers when treatment is prescribed for that reason," they wrote. Vasomotor symptoms include hot flashes and night sweats.

Dr Haitham Hamoda, spokesperson for the Royal College of Obstetricians and Gynaecologists, and chair of the British Menopause Society, told the UK's Science Media Centre that the findings "should be considered in the context of overall benefits and risk associated with HRT including symptom management and improvement in quality of life as well the bone and cardiovascular benefits associated with HRT intake.

"Every woman experiences the menopause differently. Symptoms can vary and be extremely debilitating, significantly impacting on their physical and psychological health, career, social life and relationships. Sadly, many women are still suffering in silence and are reluctant to seek advice and support due to concerns around HRT," Hamoda said to the Science Media Centre.

Not the last word

While McConway said the study was "very reassuring," he said it was unlikely to be the last word on a medical therapy that has been enveloped in mixed messages since doctors began being prescribing it widely in the late 1980s.

The use of HRT plummeted. A decade later, other data suggested that the news wasn't all bad, and that the risk of HRT might vary depending on a woman's age. The original Women's Health Initiative analysis looked at older women, who were already at risk for heart attacks, blood clots and stroke, meaning the findings might not apply to younger women.

Today, it's believed that HRT could be helpful in controlling menopausal symptoms at the time when most women begin to go through it -- in their late 40s and early 50s -- when their risk for chronic disease is lower.

Women who wish to take hormones later in life, when the risk for blood clots, stroke and cancer are higher, should discuss the options thoroughly with their doctor.

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Hormone replacement therapy not linked to an increased risk of developing dementia, study finds - CNN

For women in the U.S., breast cancer is devastatingly common. One in eight women in America can expect to develop breast cancer over the course of their lifetimes. And for Black women in the U.S., what comes after the diagnosis is especially worrying. The mortality rate for Black women diagnosed with breast cancer is 42% higher than their white counterparts.

One big reason is access limited to lower-quality resources inside and outside the hospital system, said Dr. Arlene Richardson, chair of the department of radiology at Jackson Park Hospital. It contributes significantly to all of these disparities we see in our community. There are many different social determinants of health from economic instability, including unemployment, lower quality environment, including housing and transportation in our community, lower quality and lower level of education, lower access to high quality foods and also lower quality health care assistance in our community.

In addition to higher mortality rates, a particularly aggressive subtype called triple negative breast cancer is more likely to present itself in Black women.

Dr. Surbhi Warrior, a physician at Rush University Medical Center, says that the science on TNBC is still young. Dr. Warrior took part in aresearch studythat looked at data for over 20 years of breast cancer patients more than 8000 Chicago women.

One of the things that we found was that Black women were 1.5 times more likely to present with metastatic disease, meaning that the cancer had already spread to different parts of their body, meaning it was much less curable. But we also found that Black women were 2.1 times more likely to have triple negative breast cancer. And both of these are big areas that lead to higher occurrence and mortality rates and especially for triple negative breast cancer. What that means is that these breast tumors dont express the hormone receptors of estrogen or progesterone or HER2 protein. And this is what usually breast cancer directed therapies target.

Dr. Warrior notes that for breast cancer treatment, follow-up care is as critical as the initial diagnosis but it also presents barriers for many Black women.

When we did our analysis of why there were a lot of areas where patients werent following up, we found out it was due to difficulty with child care and transportation as well as even difficulty getting time off work to go to their doctors appointments. And a lot of these competing social and economic demands that patients go through make it difficult for patients who are already presenting with advanced disease to adhere to months and months of chemotherapy and radiation and overall breast cancer care, and this long term impacts their overall mortality and their cancer outcomes directly.

Its everyday needs like those that health care organizations must consider in order to improve health outcomes for Black women, says the American Cancer Societys Michelle Hicks-Turner.

We know that these disparities are rooted in policies that contributes to the barriers to care. Not everyone can take the time off during the week to go to doctors appointments, so offering weekend and evening mammogram appointments are crucial. Also, to ensure uninsured women receive the care they need, hospitals can strengthen their partnerships with faith-based organizations, referring providers and promote the utilization of the Illinois, breast and cervical cancer program. And this would allow low-income women across the state to get care.

Hicks-Turner adds that services for health care navigation and even child care or transportation can help boost patients ability to access health care.

Jackson Park Hospital is collaborating with nonprofits Black Womens Health Imperative, the National Alliance for Hispanic Health, and medical device company Hologic to bring state of the art 3D mammography equipment to patients for breast screening plus wraparound care services. Dr. Richardson says the initiative, calledProject Health Equality, is one way Jackson Park Hospital is trying to address disparities in prevention and treatment for breast cancer.

3D mammography has proved to be superior when compared with 2D mammography alone is for detecting breast cancer, particularly in dense breast which is more common in the Black and African American community. So in addition to this technology, theres other support of innovative care including public education and nursing navigation that will be added to our side to improve our screening and treatment for women in our community that might otherwise go without.

Ultimately, Hicks-Turners bottom-line advice to Black women hoping to protect their health is straightforward.

Go get your mammogram. Its very important. It saves lives.

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Doctors on Closing the Breast Cancer Mortality Gap for Black Women - WTTW News

Consider this your 201-level guide to all the various leaves, seeds, powders, and potions that get so much buzz in the wellness scenethen discover how to actually incorporate them into your life. So whether you want to power up your smoothie with natural supplements, or you're just wondering how to use the cacao powder sitting in your pantry, you'll get the intel you need here. See All

With so many herbs, remedies, and supplements on the market, all with different and numerable benefits, it can sometimes be overwhelming to know where to start when it comes to creating the right routine for your body and its specific needs. So often patients ask herbalists to tell them "what they need" without asking themselves big questions first. On the latest episode of Plant-Based,herbalistRachelle Robinett discusses what questions to ask yourself in order to find the best herbal routine for your body and mind.

Some of the most common challenges that Robinett sees are digestion and gut health woes, sleep and energy problems, brain health struggles when it comes to mood regulation, stress, and anxiety, general wellness, and hormone imbalances. To start, it's important to understand that there's no one size fits all herbal solution for everyone. It's vital to look at your life and reflect on what support your body, brain, and lifestyle are craving. Do you need help with a specific ailment or a more preventative practice? Both are so important, explains Robinett.

Next, you have to think about what is realistic for you. What sorts of herbs will you actually stick to? How often? When? In what form? Everyone's daily routine is different, so check in with yourself to see what you can commit to, since these remedies work most efficaciously when taken regularly, and there are so many options to choose froma few big capsules, more smaller capsules, teas, additions to your morning diet, changes to your nighttime routine, etc.

Finally, what do you have around you? See what is available in your area and what role your climate, geography, and environment have in your ailments or concerns. Herbs don't only work if they are ingested. Sometimes it can be helpful to see more herbs or green around you in the form of a house plant, more time outside, lifestyle or diet changes, or more sensory in the form of essential oils. Watch the full episode to learn more about Robinett's opinions as a registered herbalist, but be sure to check in with your physician before starting any new supplements.

For more healthy recipes and cooking ideas from our community, join Well+Good's Cook With Us Facebook group.

See the article here:
This Is How To Choose the Right Herbs for Your Body and Its Needs, According to an Herbalist - Well+Good

Problems that arose at a Connecticut weight-loss camp before it closed in July included missing campers and falsified documents, newly released investigative records indicate.

After weeks of investigations, a witness list 34 people deep, and pages upon pages of interviews and inspection notes, a fuller picture of the goings-on at Camp Shane informed by state documents obtained by Hearst Connecticut through a Freedom of Information Act request is taking shape.

The state document release included an investigation narrative, interview summaries, a case summary, a license surrender affidavit, and the Notice of Proposed Licensure Action and Statement of Charges sent to camp owner David Ettenberg.

The weight-loss camp located at the South Kent School abruptly shuttered on July 13, and surrendered its 11-day-old license on Aug. 23, at which point the Office of Early Childhood and Department of Children and Families terminated their joint investigation. The investigation was announced in July after the camp closed its doors, but the OEC officially launched its investigation on July 8.

Since Ettenberg legally surrendered the license prior to the completion of the state investigation, violations that would be substantiated were not formally presented to the owner, the investigation summary explained.

In the affidavit surrendering his license, Ettenberg denies all charges set forth, but agreed that if he tried to reinstate or obtain a new license from the agency in the future, it would mean that the allegations would be deemed true.

Ettenberg has not responded to multiple requests for comment since mid-July when he said he shut camp down due to staffing issues.

The allegations in the records also include:

A camper sleeping on a common area couch.

Campers walking around unsupervised at night and in lightning storms, and who were encouraged to work out until they vomited.

Counselors leaving campers unsupervised to hang out and party in the lounge.

A counselor who yelled at and threatened to fight a camper.

Falsified medication administration training documents presented to the state.

Inappropriate comments of a sexual nature by a male camper toward a female camper.

Multiple reports of campers being bullied.

And the day before camp officially shut down, an 8-year-old girl suffered a serious head injury at camp. Her parents were leaving to pick her up when they got the phone call.

The OEC investigation summary states that multiple families, many from out of state, reported trying to contact the camp about concerns with their child and not receiving any response via email, text or phone for extended periods of time.

The most continuously reported investigation concerns, which were repeated throughout interviews with parents, campers, and a counselor, were lack of proper medical oversight and mishandling of medication.

In the final summary, the camp licensing specialist summed up her medical concerns: Serious medical needs of the campers were not met when the operator failed to provide anyone trained to provide the necessary medications, failed to prepare the staff for emergency situations, and failed to seek medical assistance from trained professionals in a timely manner. Lack of supervision and untrained/uninformed staff led to campers being injured and not properly cared for.

Earlier in the report, the investigation revealed that multiple campers had reported experiencing injuries, including sprains, knee injuries, smashed toes, and serious sunburn.

Campers were not allowed to seek medical attention for up to a week in some instances. Other campers were told if they left camp to seek medical assistance, they could not return due to COVID-19 restrictions, the documents read.

Despite multiple requests from the state, the operator of the camp never located a medically trained individual to administer medications, according to the documents. Additionally, the camp presented the state with falsified medication administration training documents, allegedly signed by a doctor who ran a training in 2019. The physician whose name was presented on the training certificate said that the signature on the certificate is not his, the report states.

The doctor, whose name is redacted, provided the OEC with samples of his signature.

The certificate submitted by Camp Shane indicates a full training for oral, topical, inhaled and injectable medications as well as auto-inject medication. The signature is found to NOT be the signature of the physician, the documents said.

Former camp director and girls head counselor Jennifer DAmbrosio, who goes by Bella, quit her job on June 29 because she was concerned about camp administration and the safety and well-being of campers, she said in an interview with Hearst Connecticut Media.

DAmbrosio was also interviewed at least two times by the OEC. Her name has been redacted in the report, labeled as first director, but her identification was independently confirmed by Hearst Connecticut Media.

DAmbrosio said she was hired two days before arriving at the camp, claiming the camp was in disorder when she arrived and that there was no paperwork ready for opening.

The summary of the conversation between the investigator and DAmbrosio included concerns about not having appropriate staff, no guidance counselor, no paperwork about medical problems, no paperwork to the nutritionist regarding allergies and food restrictions, no certified medical staff on site, and no trained person for the behavior therapy program.

The fact that there was no medical person on campus, no information for counselors about the serious medical conditions of some of the campers and that there was a lot of medication concerns contributed to [redacted] deciding to leave the camp, the summary states.

The OEC interview summary included a physician whose name was redacted from documents, along with parts of the summary of his interview.

The doctor told the OEC, according to the documents, that he had been asked to serve as camp doctor 10 days before the start of camp but declined due to the fact that he had a family vacation scheduled. He assumed the camp had found another physician. This was not the case.

The doctor agreed to help out until a replacement was found.

After an initial visit to the camp on June 30, the doctor reported having immediate concerns about the way medications were being administered.

The doctor also said that he recommended that the camp close on more than one occasion to due to lack of safety.

The new state investigation documents also show repeated instances of camper discomfort, at times the result of alleged comments of a sexual nature made by male campers towards female campers, and at others a result of bullying and a counselors alleged prior arrest that a camper found online.

One violation description reads: operator took pictures of campers during Zumba class without their consent causing them to feel uncomfortable and ill at ease.

When Ettenberg was asked about this, he explained that he took pictures of a lot of the activities on the camp for the purpose of posting on an advertising website, the interview summary reads.

In interviews with an OEC employee, a male counselor whose name has been redacted said that a female camper informed him that a male camper had made her feel uncomfortable when he made sexual remarks about her.

Another male counselor who was hired to do Cognitive Behavioral Therapy (CBT) despite not being trained in the technique prior to camp reported that he had a conversation with a female camper who told him that an older boy (who left the camp prior to [REDACTED] arriving at camp) tried to force her to have sex.

Further details were not revealed to the CBT counselor, but he told investigators that he felt he should report what he was told. The counselor estimated that the female camper was around 15 or 16 years old.

Issues persisted through the camps official shut-down on July 13. Parents were alerted of the camp's closure via email at 7:51 a.m. on July 11. The email, obtained by Hearst Connecticut Media, said the children had to leave by the following Tuesday.

In interviews, parents said they tried to figure out how to get their kids home safely with little notice booking expensive flights, calling relatives nearby or driving to the camp themselves.

On the day the camp closed, according to the investigation documents, one parent drove onto campus and picked up not only her own child, but another child as well without being asked for any identification. The records also indicate that another parent picked up her child earlier on June 30 and did not have to sign the child out or show any identification.

Camper Stellan Petto, 14, said in an interview that his general experience at camp, which included getting the wrong dosage of his essential hormone medication, definitely left me with some trauma.

Now at home with his mother in North Carolina, Stellan has entered his freshman year of high school. With some distance from his camp experience, he said hes feeling better.

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Missing campers, falsified documents and other issues revealed in CT weight-loss camp investigation - Danbury News Times

High in sugar. Zero fiber. Spikes your blood sugar. Can you think of other reasons to avoid becoming a regular juice drinker?

Vegetable and fruit juices sound super healthy (and they are actually excellent sources of vitamins and antioxidants), but as we've warned at Eatthis.com many times before, it is possible to sip a lot of juice calories in a sitting without even knowing it and experience many of those aforementioned downsides.

"Juice lacks the fiber found in whole fruits and vegetables [because] the juicing process strips fruit and vegetables of their fiber,"Sarah Rueven, MS, RD, founder ofRooted Wellness tells us. That's why she always recommends grabbing a piece of fruit over a glass of fruit juice. Or, if you'd still prefer to drink your produce, consider blending whole fruits and vegetables into smoothies, which will retain the fiber that's missing from the juicing process. (Related: Dangerous Signs You're Not Getting Enough Fiber.)

While experts may recommend whole fruit over juice whenever possible, that doesn't mean you need to avoid the fruit beverage entirelyespecially since juice can provide your diet with extra antioxidant vitamins and minerals hidden in plants. To get the most out of this juice, we wondered, what is the best juice to drink?

"If you are going to drink juice, be sure it's cold-pressed juice from fresh fruits and vegetables," says nutritionist Heather Hanks, who specializes in holistic nutrition for USA Rx. "Cold-pressed juices are not heated to high temperatures, meaning that they still contain most of the antioxidants and vitamins that are killed off during pasteurization."

Cold-pressed juices are just thatthey are made with a hydraulic press that squeezes the juice from fruits and vegetables cold, unlike juices that go through the pasteurization process, which involves high heat. While the heat and oxygen used in pasteurization kill off harmful bacteria in the liquid, it also destroys many of the nutrients in the process. The upside of pasteurized juice is its long shelf-life, whereas cold-pressed juice needs to be consumed quickly, within a day or two.

Unless you make the cold-pressed juice yourself, "make sure your juice contains no added sugars, colors, or food dyes," says Hanks. "The ingredients should be fruits and vegetables only with no fillers or preservatives."

As for types of fruits and vegetables that make the healthiest juice, nutrition research points to these. Read on, and for more on how to eat healthy, don't miss 7 Healthiest Foods to Eat Right Now.

Tart cherries contain anthocyanins, red and purple plant pigments that offer strong antioxidant activity that reduces inflammation. In animal studies published in the Journal of Medicinal Food, rats were fed a high fat diet and either freeze-dried tart cherry powder or a control diet of equal calories but without the tart cherry addition. Only those fed the tart cherries experienced a 9% reduction in abdominal fat and other markers of metabolic disease. Tart cherry juice is also a sleep enhancer, the anthocyanins and tryptophan compounds in the juice boost production of the sleep-inducing hormone melatonin.

RELATED:Popular Drinks That Fight Inflammation, Say Dietitians

Another juice that's rich in anthocyanins (you can tell by the red color) is cranberry. Registered nutritionist Jay Cowin, director of formulations for ASYSTEM calls it one of the healthiest juices you can drink. Loaded with cell-protecting antioxidants, including vitamins C and E,"cranberry juice has also be found to be anti-inflammatory and may help to ease symptoms ofrheumatoid arthritis (RA) and offer protection against heart disease," he says.

When buying cranberry juice, it's important to check the label and make sure that it says, "Contains 100 percent juice" and does not contain added sugar, preservatives, or additives.

RELATED: Sign up for our newsletter to get daily recipes and food news in your inbox!

If you have high blood pressure, ask your doctor about drinking beetroot juice, which contains nitrates that have been proven to improve blood pressure by relaxing blood vessels. "Beetroot juice is low in sugar content in comparison to other juices and is also an amazing source of vitamin B-6, calcium, and iron," says Elliot Reimers, a sports nutritionist certified by the International Society of Sports Nutrition and the National Academy of Sports Medicine. The deep red of beets is due to pigments called betalains, phytonutrients that "inhibit signaling pathways that are connected to many inflammatory diseases," Reimers says.

Turning a couple of stalks of celery into pulpy juice may help with weight loss because it has only about 30 calories in 16 ounces and delivers 3 grams of filling fiber. Plus, celery has been shown to have powerful antioxidant properties to remove free radicals, according to a study in The Journal of Evidence-Based Complementary & Alternative Medicine.

Watermelon juice is touted as an excellent low-sugar beverage for sports rehydration by physician Mark Hyman, MD, the New York Times best-selling author of Food: What The Heck Should I Eat? The amino acid L-citrulline found in watermelon helps move lactic acid out of muscles, reducing soreness and fatigue, another reason to drink it after a tough workout. Researchers in the Journal of Agricultural and Food Chemistry found that athletes who drank watermelon juice as an exercise beverage reported less soreness and slower heart rate 24 hours after working out.

Read this next:

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The #1 Best Juice to Drink, Says Nutritionist | Eat This Not That - Eat This, Not That

Q. Im a 63 year old man and I hate exercise. My physician and wife urge me to do so. Okay, Im a little overweight, but Im doing well all of these years. What encouragement and justification for exercising? PA

Getting Started: We cant let people do what they dont want. There is always a reason to disagree with the facts, find exceptions, and ignore advice. At the same time, it is important to recognize that it is difficult to change lifelong behavior and attitudes.

So when will health behavior change? When written on the prescription, they often change with the next verbal message from the doctor: Living past the age of 75 or attending a daughters wedding, grandsons blessing, or grandsons Bar Mitzvah. If you want to, we strongly recommend the following:

During the pandemic, the sofa became a close friend of many.according to Pew Research CenterPeople over the age of 60 spend about half of their leisure time in front of the screen. In most cases, TV is about 4 hours a day.

Its time to get up from the couch and start a simple exercise, walking. You dont need equipment, you just need good walking shoes. No special clothing or training required, its free. We know that taking certain steps each day can reduce the risk of coronary heart disease, stroke, colon cancer, and type 2 diabetes. It can lower blood pressure, increase muscle strength, prevent falls and injuries, reduce depression and burn calories.

This is a bonus benefit. People who are physically active tend to live longer than those who are not. One way to define physical activity is the number of steps you take each day. Ive heard about the magical daily goal of 10,000 steps that you can easily record on your smartwatch, iPhone, or Fitbits. There is some controversy over the exact number of daily steps to improve health and longevity.

Researchers at the University of Massachusetts Amherst, the CDC, and other institutions have found a strong link between steps and mortality. They found that men and women who accumulated 7,000 steps a day were about 50% less likely to die than those who walked less than that number. At 9,000 steps, the chances of premature death were 70% lower than those with less than 9,000 steps. With 10,000 steps, the benefits were leveled. People who take more than 10,000 steps a day rarely live longer than those who take at least 7,000 steps. For each story of the New York Times on September 21st..

There is still more to confuse the problem. The JAMA Internal Medicine online publication contains a study of over 16,000 women with an average age of 72 years. Women with an average of about 4400 steps per day had significantly lower mortality than the least active women with an average of about 2700 steps per day. ..

And there is one more from National Institute on Aging.. They recommend that adults require 150 minutes or 2.5 hours of moderate-intensity aerobic exercise per week to stay healthy. Active walking is a good example. The 30 minutes can be divided into three 10 minute walks.

This is the benefit of the Super Bonus. Walking is good for your brain health. Dr. Dean Sherzai, a clinical neurologist and co-director of the Loma Linda University Brain Health and Alzheimers Disease Prevention Program, identified three links between exercise and improved brain health. He said exercise increases blood flow to the brain, providing more oxygen and nutrients. At the same time, it flushes inflammatory and oxidative elements from the brain, increasing chemicals like neuronal growth hormone, but especially for connections between neurons. PBS Next Avenue, A digital platform for information for baby boomers. Both aerobic and anaerobic exercise are effective, he added.

The bottom line is that walking is a good exercise to add brain health benefits and improve overall health, function, fitness and longevity. These remedies and interventions are not purchased at local CVS or Walgreens.

AP Thank you for your important question. I would appreciate your encouragement. Now, after stretching, put on your shoes and get out of the door. Take a walk with your friends and dogs, greet your neighbors, smell the roses and enjoy the beautiful weather. Stay safe and get well. Of course, be kind to yourself and others.

Note: Check with your healthcare provider before starting an exercise program.

Helen Dennis is a nationally recognized leader in new retirement issues with aging, employment, and academic, corporate, and non-profit experience. Contact Helen with any questions or comments at Helendenn@gmail.com. Visit Helen on HelenMdennis.com and follow her on facebook.com / Successfulaging Community.

Need motivation to exercise? Here are some reasons to get moving Press Telegram Source link Need motivation to exercise? Here are some reasons to get moving Press Telegram

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Need motivation to exercise? Here are some reasons to get moving Press Telegram - California News Times

RICHLAND PUBLIC HEALTH FLU SHOTS AVAILABLE BY APPOINTMENT

Richland Public Health flu vaccines will be available by appointment starting in October through our Public Health Clinic. Call 419-774-4700 to schedule a flu shot for you and your family.

Everyone from age six months and up should get an annual flu shot. The Centers for Disease Control and Prevention (CDC) recommends getting your flu shot in October, but if you miss that month, get one as soon as possible.

Influenza is a contagious disease that spreads around the United States every year, usually between October and May. Flu is caused by influenza viruses, and is spread mainly by coughing, sneezing, and close contact. Anyone can get the flu. Flu strikes suddenly and can last several days. Symptoms vary by age, but can include: fever/chills, sore throat, muscle aches, fatigue, cough, headache, and runny or stuffy nose.

Flu is more dangerous for some people. Infants and young children, people 65 years of age and older, pregnant women, and people with certain health conditions or a weakened immune system are at greatest risk.

No one likes to be sick. Getting the flu will cause you to miss work or school, along with your favorite activities, Amy Schmidt, Director of Nursing at Richland Public Health, said. You might also pass the flu on to your family, friends, or co-workers. Protect yourself and others. Get your flu shot.

According to the CDC, cold and flu season runs from approximately October to May, with a peak somewhere between December and February. Flu can be widespread, with up to 49 million cases each year in the United States.

Last year, the flu season was very mild due to restrictions in place for COVID-19 such as masking, social distancing, closing of mass events, and remote learning for schools. With most of those restrictions not in place, health experts are predicting a rise in flu cases. Thats worrisome, considering the strain hospitals are already experiencing with COVID cases. Its another reason to make sure to get your flu shot in October.

For additional information about influenza, visit the CDC at https://www.cdc.gov/flu/or talk with your pediatrician or family physician. For special home-bound services, call 419-774-4540.

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Originally posted here:
October Health and Safety | Richland Health - Richland Public Health

Every person, every mouse, every dog, has one unmistakable sign of aging: hair loss. But why does that happen?

Rui Yi, a professor of pathology at Northwestern University, set out to answer the question.

A generally accepted hypothesis about stem cells says they replenish tissues and organs, including hair, but they will eventually be exhausted and then die in place. This process is seen as an integral part of aging.

Instead Dr. Yi and his colleagues made a surprising discovery that, at least in the hair of aging animals, stem cells escape from the structures that house them.

Its a new way of thinking about aging, said Dr. Cheng-Ming Chuong, a skin cell researcher and professor of pathology at the University of Southern California, who was not involved in Dr. Yis study, which was published on Monday in the journal Nature Aging.

The study also identifies two genes involved in the aging of hair, opening up new possibilities for stopping the process by preventing stem cells from escaping.

Charles K.F. Chan, a stem cell researcher at Stanford University, called the paper very important, noting that in science, everything about aging seems so complicated we dont know where to start. By showing a pathway and a mechanism for explaining aging hair, Dr. Yi and colleagues may have provided a toehold.

Stem cells play a crucial role in the growth of hair in mice and in humans. Hair follicles, the tunnel-shaped miniature organs from which hairs grow, go through cyclical periods of growth in which a population of stem cells living in a specialized region called the bulge divide and become rapidly growing hair cells.

Sarah Millar, director of the Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai, who was not involved in Dr. Yis paper, explained that those cells give rise to the hair shaft and its sheath. Then, after a period of time, which is short for human body hair and much longer for hair on a persons head, the follicle becomes inactive and its lower part degenerates. The hair shaft stops growing and is shed, only to be replaced by a new strand of hair as the cycle repeats.

But while the rest of the follicle dies, a collection of stem cells remains in the bulge, ready to start turning into hair cells to grow a new strand of hair.

Dr. Yi, like most scientists, had assumed that with age the stem cells died in a process known as stem cell exhaustion. He expected that the death of a hair follicles stem cells meant that the hair would turn white and, when enough stem cells were lost, the strand of hair would die. But this hypothesis had not been fully tested.

Together with a graduate student, Chi Zhang, Dr. Yi decided that to understand the aging process in hair, he needed to watch individual strands of hair as they grew and aged.

Ordinarily, researchers who study aging take chunks of tissue from animals of different ages and examine the changes. There are two drawbacks to this approach, Dr. Yi said. First, the tissue is already dead. And it is not clear what led to the changes that are observed or what will come after them.

He decided his team would use a different method. They watched the growth of individual hair follicles in the ears of mice using a long wavelength laser that can penetrate deep into tissue. They labeled hair follicles with a green fluorescent protein, anesthetized the animals so they did not move, put their ear under the microscope and went back again and again to watch what was happening to the same hair follicle.

What they saw was a surprise: When the animals started to grow old and gray and lose their hair, their stem cells started to escape their little homes in the bulge. The cells changed their shapes from round to amoeba-like and squeezed out of tiny holes in the follicle. Then they recovered their normal shapes and darted away.

Sometimes, the escaping stem cells leapt long distances, in cellular terms, from the niche where they lived.

If I did not see it for myself I would not have believed it, Dr. Yi said. Its almost crazy in my mind.

The stem cells then vanished, perhaps consumed by the immune system.

Dr. Chan compared an animal's body to a car. If you run it long enough and dont replace parts, things wear out, he said. In the body, stem cells are like a mechanic, providing replacement parts, and in some organs like hair, blood and bone, the replacement is continual.

But with hair, it now looks as if the mechanic the stem cells simply walks off the job one day.

But why? Dr. Yi and his colleagues next step was to ask if genes are controlling the process. They discovered two FOXC1 and NFATC1 that were less active in older hair follicle cells. Their role was to imprison stem cells in the bulge. So the researchers bred mice that lacked those genes to see if they were the master controllers.

By the time the mice were 4 to 5 months old, they started losing hair. By age 16 months, when the animals were middle-aged, they looked ancient: They had lost a lot of hair and the sparse strands remaining were gray.

Now the researchers want to save the hair stem cells in aging mice.

This story of the discovery of a completely unexpected natural process makes Dr. Chuong wonder what remains to be learned about living creatures.

Nature has endless surprises waiting for us, he said. You can see fantastic things.

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Losing Your Hair? You Might Blame the Great Stem Cell Escape. - The New York Times

It is too late for conservation efforts to save the northern white rhinoceros, but with recent scientific advancements there may still be hope to bring back this beloved species. In a recently published paper, scientist Marisa Korody and her colleagues at San Diego Zoo Global (USA) and at the Department of Molecular Medicine at Scripps Research (USA) describe their exciting progress on using stem cells to revive the northern white rhino.

The northern white rhino is functionally extinct, meaning there are not enough of these rhinos left to save the species. In fact there are only two northern white rhinos left: a mother and a daughter. But for decades, scientists have preserved cell samples from 15 northern white rhinos containing enough genetic material to potentially bring this species back from the brink. These preserved samples hold fibroblast cells the type of skin cells that secrete collagen from white rhinos. With these scientists newly developed methods, fibroblast cells can be converted into something much more valuable: induced pluripotent stem cells. These stem cells can differentiate into any cell type in the body including heart cells, muscle cells, and reproductive cells.

In theory, by converting fibroblast cells into reproductive cells, scientists could create genetically unique rhino embryos. Alongside other assisted reproduction technologies, scientists could implant a new embryo into a closely-related southern white rhino, where the baby northern white rhino could develop as an otherwise normal pregnancy. By completing this process multiple times, scientists may be able to establish a stable population of northern white rhinos.

In 2011, this research team generated induced pluripotent stem cells from the samples of another endangered species, but unfortunately since this process was found to harm the recipient genomes, this method was largely unsuccessful. Despite this setback, in 2015 the authors met with colleagues worldwide to consider ways to save the northern white rhino, and they concluded that methods involving induced pluripotent stem cells may still be the most promising solution. Over the following years, the scientists worked to improve their methods, and these improvements are documented in their recent paper. These experiments represent the first step in a long-term plan to bring the northern white rhino back through assisted reproduction techniques.

Right from the start, the scientists faced a whole host of challenges. Through trial and error they modified the growth medium for the cells, optimizing it for rhinoceros cells. With their improved growth medium, scientists successfully generated induced pluripotent stem cell lines from 11 rhinoceros individuals. This has never been done before and represents a huge stride forward in the path to recovering this species.

Before trying to make their first rhino, the scientists needed to stress these induced pluripotent stem cells and sequence their genomes to determine if the cell quality is good enough to potentially produce new, viable rhinos. They maintained colonies of these cells in long-term cultures and exposed these colonies to different conditions to give insight into how resilient these cells could be. These tests demonstrated that long-term culture did not affect the potential for these cells to differentiate into cardiac lineage cells, confirming that these cells are stable long-term. The researchers also confirmed that these pluripotent cells could potentially produce gametes, the egg and sperm cells that are used for sexual reproduction. These advancements indicate that with these newly developed protocols, induced pluripotent stem cells are a promising tool that could someday help recover the northern white rhino.

Although this study includes some exciting results, there is still much work to do. For example, scientists must now sequence the genomes of the northern and southern white rhino so other researchers can analyze the stem cells ability to stay the same over time. Despite the work that still needs to be done, these promising advancements could someday help the northern white rhino population recover. This method may also work for saving other endangered or extinct species, as long as the genetic material needed is available. Long-term, these scientists plan to continue a series of experiments that could ultimately bring this beloved rhino, and potentially other endangered species, back from the brink of extinction.

Go here to read the rest:
Stem cells may be the key to saving white rhinos from extinction - Sciworthy

As a beauty writer and longtime skincare fanatic, Ive subscribed to various multi-step routines. Fast forward to having a baby and the general day-to-day life upheaval that comes along with it, and my definition of a worthwhile personal beauty regimen has changed a bit. While I still enjoy trying new products and learning about innovations in the beauty space, I find myself with less time (and patience) for the more laborious treatments and layering routines, and more interest in noticeable efficacy and multitasking capabilities.

The most effective skincare products and tools are great for paring down your routineand also ... [+] saving you some precious minutes in your day.

And whether youre a busy mom or simply short on me time these days (who isnt?), there are a myriad of tried-and-true products that get the job done without requiring a ton of effort on your part. From Herauxs next-level anti-inflammaging serum to NuFaces skin-smoothing device, these standout skincare products and tools are ideal for a results-driven regimen thats effective enough to knock a few steps off your routineand save you some precious minutes in your day.

Since its launch seven years ago, this antioxidant-rich hydrating facial oil has remained a cult favorite for anyone who wants an instant glow, with the added benefit of skin soothing, balancing and repair. Infused with 22 active botanical and essential oils, the lightweight yet potent treatment can help with everything from acne to sun damage. And when applied using founder April Gargiulos signature push-press technique, it feels like a simple yet luxurious way to start and end the day.

Like the brands Trinity device, the NuFace Fix uses microcurrent technology at a gentler level to help reduce the look of fine lines and wrinkles on the more delicate areas of the face: on the forehead, between brows and around the eyes and lips (filler-free plumping, anyone?). Its sleek, compact shape combined with ease of use makes it a no-brainer for skin smoothing results in a matter of minutes. Plus, it holds an ample 120-minute charge, which amounts to a couple months worth of use before needing to plug it ini.e. no fumbling with cords or a hefty device on a regular basis.

The latest product in Kate McLeods sustainably packaged, handcrafted self care collection and the first to focus on skincare, the Face Stone is essentially a waterless moisturizer that melts on contact with skin. A rich blend of nourishing and antioxidant ingredients like blue tansy, kokum butter and plum kernal borage helps even and soothe stressed skinsomething we could all use these days. An added bonus? Its solid form and shape makes it a natural massaging tool, making it ideal for a morning pick-me-up or the start of an evening wind-down ritual.

While it covers your mineral-based broad spectrum sunscreen needs, this multitasker does much more than that. The unique product uses the U Beautys proprietary Sun-Siren Capsule Technology to help reduce hyperpigmentation, discoloration and dark spots (whether from pregnancy melasma or suntanning sins of the past) while also shielding against UVA, UVB, infrared and blue light exposure. A little goes a long way with this rich balm-cream formula, and its hydrating enough to double as a moisturizer or primer by day and also great as an overnight spot treatment.

An excellent (and cleaner) dupe for Biologique Recherches oft-elusive Lotion P50, this Moon Juice exfoliator is a skin savior in its own right. The liquid formula includes glycolic, lactic and salicylic acids for gentle, pore-minimizing exfoliation paired with niacinamide and adaptogenic reishi to help boost the skins natural barrier. And besides looking pretty, the packaging is completely recyclable, from the sculptural cap and glass bottle to the outer carton.

January Labs is a clean beauty favorite for its science-backed, results-driven products that have long been favored by top aestheticians. Even those with more sensitive (or dry) skin can use this retinol serum without dealing with typical downsides (like redness, drying or peeling) thanks to its use of Retistar, a .5% retinol thats super effective yet non-irritating.

This at-home peel is as easy as can be, requiring a single once-over with the pre-soaked pad to revive dull skin. The duo of glycolic and salicylic acids provide skin-smoothing exfoliation while ingredients like chamomile and bilberry extract calm, soothe and help even skin tone. Pro tip: Use up excess product on any dry, flakey patches on arms and legs.

Created by stem cell biologists at the University of Southern California, this innovative serum features an anti-inflammaging HX-1 molecule thats combined with tried-and-tested ingredients like vitamin C, hyaluronic acid, peptides and red maple bark. The result? A silky, lightweight formula thats both rejuvenating (designed to help reduce the effects of stress and aging factors on skin) and preventative (strengthening stem cells on a molecular level).

Visit link:
The Best Skincare Treatments For Time-Crunched Moms (Or Anyone Else Who Only Has Five Minutes To Spare) - Forbes

A recent article in the journal Nature credits Stanford physician-neuroscientist Sergiu Pasca, MD, with blazing a trail toward a more profound understanding of early brain development, and of what can go wrong in the process, using a cell-based research innovation he named "assembloids."

In 2015, Pasca and his colleagues published a paper in Nature Methods describing a fascinating feat: His tinkering with induced pluripotent stem cells, or iPS cells -- former skin cells transformed so that they've acquired an almost magical capacity to generate all the tissues in the body -- had borne a three-dimensional product. From these "magic" iPS cells grew a complex conglomerate of cells capable of modeling specific organs.

Pasca's particular interest was in the brain, and in the experiments detailed in the study, his lab had caused human iPS cells to multiply and differentiate into small spherical clusters of brain tissue suspended in laboratory glassware.

These clusters recapitulated the architecture and physiology of the human cerebral cortex -- the outermost layer of brain tissue, critical to perception, cognition and action. Pasca named these clusters, which grew to several millimeters in diameter and contained millions of cells, "cortical spheroids." Today, researchers around the world are using similar methodology to create models, broadly known as "organoids," to study other parts of the human body.

Two years later, in a study published in Nature, Pasca upped the ante by, first, generating a second kind of neural spheroid -- this time, representative of a deeper part of the developing forebrain called the subpallium -- and, second, by growing this kind of spheroid in conjunction with cortical spheroids, in the same dish.

To the researchers' amazement, spheroids of both types fused together, with nerve cells from subpallial spheroids migrating and poking extensions into the cortical spheroids and establishing working connections with nerve cells of a different type in the latter spheroids, just as occurs in fetal development.

"It's amazing that these cells already self-organize and know what they need to do," Pasca marveled in "Brain Balls," an article I wrote for our magazine, Stanford Medicine, a few years ago.

Pasca sensibly dubbed the two-fused-spheroid combos "assembloids," the Nature recap notes.

But why stop at two? Pasca has since created three-element assembloids composed of spheroids representative of cerebral cortex, spinal cord and skeletal muscle in order to model the circuitry of voluntary movement. He's also shown that stimulating the "cerebral cortex" spheroid can result in contraction of the "muscle" spheroid. (This accomplishment was published in Cell in late 2020.) He has explored other assembloid combinations, as well, such as the fusing of cortical spheroids with spheroids representing the striatum, a brain structure implicated in regulating our movements and responses to rewarding and aversive stimuli.

Because each spheroid begins with skin cells, they can be grown on a personalized basis -- and can therefore be extracted from patients with neurological disorders known or suspected to spring from early developmental aberrations (such as autism or schizophrenia). The cells can then be used to create models to probe these disorders' molecular, cellular and circuit-based deviations from the pathways of normal brain development, allowing scientists to study the brain in way they could never do with a living patient.

From the Nature article:

Assembloids are now at the leading edge of stem-cell research. Scientists are using them to investigate early events in organ development as tools for studying not only psychiatric disorders, but other types of disease as well.

An assembloid is by no means a complete, working brain. But, the article notes, "Pasca stands by the aphorism that all models are wrong, and some are useful. 'There's been important progress in the field in a short period of time,' he says."

Photo courtesy of the Pasca laboratory

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Stanford neuroscientist's 'assembloids' pave the way for innovative brain research - Scope

Fall is here, and now is the perfect time to upgrade your beauty routine for the cooler temperatures. Here are a few of our favorite products:

Parfums de Marly

The famed perfume house founded by Julien Sprecher will launch sensual Oriana on September 12th. Packaged in a hot pink bottle, the airy and dreamy fragrance is captivating withnotes of orange blossom, marshmallow, and Chantilly cream. Available on parfums-de-marly.com and Saks Fifth Avenue. $320.

ILONA

This innovative skincare brand continuously seeks out innovative ingredients and technologies from around the world and incorporates them into premium high-performance formulas like the BEYOND C Corrective Serum. This reincarnating serum is housed in a beautiful dual vessel package. One side is black, the other gold with each containing corrective technologies that reach maximum potency at the moment of unity.

The black side contains a novel probiotic and micronized niacin that fortifies skin defenses, intensifies cellular activity, quells inflammation, and amends blotchiness. The gold vessel contains a patented, hyper-potent, permeable form of vitamin C that helps brighten, fade age spots, even skin tone, and protect against oxidation. $132.

Heraux

This innovative product was created by Heraux Co-Founder Dr. Ben Van Handel, a Stem Cell Biologist at the University of Southern California and leading inflammaging researcher. Dr. Handel notes that Retinols are anti-inflammatory at the molecular level, acting as antioxidants and blocking hyperactivation of the immune system. HX-1, the proprietary ingredient in HerauxsMolecular Anti-Inflammaging Serum, acts to shield skin stem cells from pro-inflammaging stressors and concurrently supports the youthful function of stem cells. The regenerative program enabled by HX-1 promotes the secretion of collagen and elastin as well as improved skin barrier function.

Kimberly Fisher is a Pursuitist contributor. As a freelance writer and on-camera host, Kimberly has traveled the world and has published over 400 articles in over 44 publications including Sherman's Travel, Huffington Post, Just Luxe, Luxury Lifestyles UK, eHow, Examiner, Food Wine Travel Magazine, Luxe Beat, NiteGuide, Ocean View, and USA Today. Disclosure: Kimberly is employed by Remy Cointreau Americas.

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3 of the Best Fall Beauty Buys - Pursuitist

According to a study published in Nature, a journal, researchers have found the reason behind obesity leading to hair thinning.Also Read - Surgery For Weight Loss: What is Bariatric Surgery, How Does it Help in Reducing Weight, And Is it Safe?

They found that stem cells within hair follicles in mice given a high-fat diet behaved differently from those in mice with a standard diet. Inflammatory signals in the stem cells led to these differences, ultimately resulting in hair thinning and loss. These fascinating data shed light on the complicated link between obesity and organ dysfunction. Also Read - Study Suggests Obesity is Not Caused by Overeating, it Depends on Quality of the Food

Its well known that obesity is linked to the development of numerous diseases in humans. Heart disease, diabetes, and other ailments are extremely common in obese individuals. However, its not fully clear how body organs specifically deteriorate and lose functionality from chronic obesity. Also Read - What is a Hormonal Belly? 3 Vital Signs That Your Hormones Are The Reason Behind Your Belly Fat

In a recent study, a group of researchers from Tokyo Medical and Dental University (TMDU) used mouse model experiments to examine how a high-fat diet or genetically induced obesity can affect hair thinning and loss.

The authors found that obesity can lead to depletion of hair follicle stem cells (HFSCs) through the induction of certain inflammatory signals, blocking hair follicle regeneration and ultimately resulting in loss of hair follicles.

Normally, HFSCs self-renew every hair follicle cycle. This is part of the process that allows our hair to continuously grow back. As humans age, HFSCs fail to replenish themselves leading to fewer HFSCs and therefore hair thinning.

Although overweight people have a higher risk of androgenic alopecia, whether obesity accelerates hair thinning, how and the molecular mechanisms have been largely unknown. The TMDU group aimed to address those questions and identified some of the mechanisms.

High-fat diet feeding accelerates hair thinning by depleting HFSCs that replenish mature cells that grow hair, especially in old mice. We compared the gene expression in HFSCs between HFD-fed mice and standard diet-fed mice and traced the fate of those HFSCs after their activation, said the lead author of the study Hironobu Morinaga.

We found that those HFSCs in HFD-fed obese mice change their fate into the skin surface corneocytes or sebocytes that secrete sebum upon their activation. Those mice show the faster hair loss and smaller hair follicles along with depletion of HFSCs. Even with HFD feeding in four consecutive days, HFSCs shows increased oxidative stress and the signs of epidermal differentiation, Morinaga added.

The gene expression in HFSCs from the high-fat-fed mice indicated the activation of inflammatory cytokine signalling within HFSCs. The inflammatory signals in HFSCs strikingly repress Sonic hedgehog signalling that plays a crucial role in hair follicle regeneration in HFSCs, described Emi K. Nishimura, a senior author.

The researchers confirmed the activation of the Sonic hedgehog signalling pathway in this process can rescue the depletion of HFSCs.

This could prevent the hair loss brought on by the high-fat diet, said Nishimura.

This study has provided interesting new insights into the specific cellular fate changes and tissue dysfunction that can occur following a high-fat diet or genetically induced obesity and may open the door for future prevention and treatment of hair thinning as well as for the understanding of obesity-related diseases.

(With inputs from ANI)

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Can Obesity Lead to Hair Fall? Here's What The Research Says - India.com

Facial serums are skin care products that the skin can absorb rapidly. They are formulated to contain high doses of ingredients, including actives such as vitamin C and retinol. They are not moisturizers. Instead, they are an additional step in a skin care routine selected to address specific skin concerns.

While many facial serums make claims about their benefits, limited scientific data is available to support these claims. The potential uses and benefits of a serum will depend on the ingredients and their concentration.

Many serums use active ingredients such as:

Common issues face serums claim to address include acne, rosacea, and signs of aging such as wrinkles.

One study of a facial serum targeting fine lines and wrinkles found that after 12 weeks, women showed statistically significant improvements in:

Face serums are generally considered safe. They are available without a prescription. However, because face serums deliver concentrated doses of active ingredients such as vitamin C or hyaluronic acid, people should exercise caution when trying them for the first time.

Pregnant people should exercise caution when selecting skin care products. Using products made with concentrated forms of vitamin A, such as retinol, can harm a developing fetus. Pregnant people should avoid skin care products that contain retinoids or other harmful ingredients.

People who are already using prescription or high dosage skin care products should check with their healthcare providers before using face serums to ensure they are not taking in unhealthy levels of powerful ingredients, such as retinoids.

When introducing a new active ingredient to the skin, there is a possibility of side effects such as:

If a person experiences these symptoms, they should reduce the frequency and dosage of the serum or stop using it altogether if symptoms do not reduce.

The American Academy of Dermatology recommends trying just one new product, like a facial serum, at a time. Starting several new products all at once, particularly anti-aging products, can irritate the skin and make it difficult to determine which products are beneficial.

It is also helpful to perform a patch test for a week before using a new product on facial skin. A patch test involves applying small amounts of the new product on the inner forearm for a few days to check for reactions.

A skin serum will not be effective if it is not used properly. The best time to apply face serum is after cleaning the skin and before applying moisturizer.

Facial serums are concentrated, so people should only use a small amount to cover the facial skin.

Learn more about skin care routines here.

No single skin care product can address all skin health needs. To pick out the best face serum, a person should first decide what skin concern they want to address, such as wrinkles or acne.

Look for a face serum that is a good fit for individual concerns and needs. For example, a person should choose a face serum that suits their skin type, such as oily, dry, combination, or aging.

Some people may wish to find products that are hypoallergenic and noncomedogenic, which means they are less likely to cause allergic reactions or acne.

Products do not have to be expensive to be effective, and serums are available to suit various budgets.

Please note that the writer of this article has not tried these products. All information presented is purely research-based.

This is an oil-free vitamin C face serum designed for people with oily or blemish-prone skin.

SkinCeuticals claims this serum can reduce skin oiliness and wrinkles, and improve skin texture.

The ingredients include:

This serum costs $166 for a 30ml bottle.

Made with Avene Thermal Spring Water, this water-gel serum is safe for adolescents and adults.

It is suitable for oily skin and should be used after cleansing in the morning and evening.

Avena claims that this product can be used safely alongside other acne treatments and can reduce the appearance of pores.

This serum costs $28.00 for 30ml.

This antioxidant face serum is fragrance- and oil-free, and certified cruelty-free.

Drunk Elephant claims it can reduce the signs of sun damage and aging while hydrating the skin. It stays active on the skin for up to 72 hours and should be applied in the morning.

Customers must mix a powder and liquid to create the fresh activated serum.

This serum costs $78.00 for 28ml.

This face serum contains aloe, vitamin A, niacinamide, vitamin C, vitamin E, tea tree oil, and other vitamin and herbal ingredients.

Klur states that this serum may even out skin texture, helps calms inflammation, and increases skin clarity.

People should use it at night and no more than 3 times a week.

This serum costs $110.00 for 30ml.

This serum uses forms of retinoid that The Ordinary states may reduce the signs of aging better than other retinoid products, without causing irritation.

The company recommends people patch test the serum, before using it on facial skin. People should not use it in combination with other retinoid products.

Use only in the evening after cleansing, and refrigerate after opening.

This serum is vegan and free from oil, silicones, nuts, and gluten.

This low-cost serum sells for $9.80 for 60ml.

This cruelty-free skin serum contains milk protein, seaweed extract, and arnica. Ren claims it may calm and soothe the skin while reducing redness and irritation.

It should be used morning and/or night before moisturizing.

This serum costs $58.00 for 30ml.

True Botanicals claims that this anti-aging serum may reduce the appearance of fine lines and wrinkles.

It uses natural antioxidants such as chebula, elderberry, ginger, and echinacea to help strengthen the skins immunity to signs of aging.

After morning and evening cleansing, users can apply one half or full drop to their faces.

This serum costs $90.00 for 30ml.

Skin Authority claims that this lightweight serum reduces the appearance of fine lines, by plumping skin folds and smoothing skin texture.

This serum is designed for use after morning cleansing.

This serum costs $155.00 for 15ml.

Peach and Lily claims that this serum can brighten the skin and reduce the appearance of dark spots.

It contains various ingredients from botanical sources, including green tea extracts, mushrooms, and arbutin. It also contains niacinamide.

It is suitable for all skin types.

This serum costs $39.00 for 50ml.

SkinCeuticals claims that this serum may reduce the appearance of dark spots and improves skin tone.

Ingredients include:

It is suitable for people with all skin types.

This serum costs $98.00 for 30ml.

Bioderma claims that this face serum may increase the skins ability to retain moisture. Made specifically for people with dry skin, it is noncomedogenic, meaning it will not block pores.

People can use this serum in the morning and evening.

This serum costs $27.99 for 40ml.

This serum is suitable for use by people with all skin types. Eminence claims that this face serum helps reduce the appearance of sun-induced skin damage.

Its active ingredients include vitamin C and other antioxidants, which work together to brighten the skin and improve the appearance of fine lines and wrinkles.

This serum costs $110.00 for 30ml.

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12 of the best face serums 2021 - Medical News Today

A man went to a clinic in Mannheim, Germany, where tests found that the rash on his hands and elbows was in fact leukaemia cutis, where the cancer cells are in the skin tissue

Image: NEJM)

A man suffering from a nasty skin rash on his hands and elbows that looked like psoriasis found that it was actually a form of leukaemia.

The 65-year-old went to a dermatologist in Mannheim, Germany, due to the red patches that had developed on the back of his hands and arms and he later found the worrying diagnosis that it was leukaemia cutis.

Tests done at the hospital showed that he had a high white-cell count along with a low number of platelets, it is reported.

The case was published in the New England Medical Journal where it said that a diagnosis of leukaemia cutis was made.

While extremely rare, the condition means that the leukaemia cells are in the skin tissue.

It is found to happen in around three percent of leukaemia cases where the rash has been found on skin including the arms, back or face.

Image:

Other leukaemia symptoms include fever, tiredness and susceptibility to infections.

But in the case of the 65-year-old in Germany, he only had the rash on his hands and elbow.

The New England Medical Journal stated: "A diagnosis of leukemia cutis was made, and the patient was urgently referred to the oncology clinic.

"The patient received a diagnosis of chronic myelomonocytic leukaemia and underwent stem-cell transplantation.

"Two weeks after the transplantation, the patients skin changes had resolved, and the cancer has been in remission since."

Leukaemia Care UK said that usually patients who have the cancer and find rashes do not have this particular condition.

It stated: Leukaemia cutis is very rare, occurring in only about three percent of total cases of leukaemia.

"With this in mind, it is unsurprising that most lesions seen in leukaemia patients are not leukaemia cutis.

In fact, most lesions (40%) seen in leukaemia patients are caused by other complications of leukaemia.

It continued: In the rare occasion that leukaemia cutis occurs, the patient will normally have already been diagnosed with leukaemia.

"However, in seven percent of cases of leukaemia cutis, the skin lesion is the very first symptom of a blood cancer. This is sometimes referred to as aleukaemic leukaemia cutis.

Link:
Man discovers nasty red rash on his hands and elbows is potentially fatal - The Mirror

Your skin is your largest organ, which means it's well worth whatever investment you decide to put toward maintaining its health. While budget beauty can certainly get the job done, sometimes you can't help but lust after the La Mers and La Prairies of the world. Though these types of pricey productsmany of which you probably recognize from the shelfies of the ultra-rich-and-famousalmost never go on sale, right now you can snag them for seriously discounted prices as a part of the Friends and Family Saks Skin-Care Sale.

Wondering how you can suss out which products are worth the splurge? Generally, serums and oilswhich have the highest concentrations of active ingredientstend to give you the most bang for your buck. Beyond that, though, "its important to evaluate and investigate the active ingredients in each product and not simply choose a product based on its marketing, packaging, or promises," Rachel Nazarian, MD, a board-certified dermatologist based in New York City, previously told Well+Good. Lucky for you, our beauty editors have done all the legwork in sorting through Saks' on-sale skin care to determine which products live up to their hefty (albeit currently discounted) price tags. Keep scrolling to shop our picks.

Photo: Estee Lauder

Este Lauder Advanced Night Repair Serum Duo Synchronized Multi-Recovery Complex $153.00

Originally $180, now $153

Consistently ranked as the number-one anti-aging serum in the U.S., this serum optimizes your skin natural repair process to fend off multiple signs of aging, including fine lines, wrinkles, and discoloration. Though its got a lofty price tag, it serves double duty as a skin-protecting antioxidant serum during the day and a skin-recovery anti-aging serum at night.

La Prairie Skin Caviar Skin Caviar Nighttime Oil $451.00

Originally $530, now $451

Nothing says indulgent quite like caviar, which happens to be the star ingredient in this evening oil. The luxe formula includes both caviar-derived retinol and lipids, which work together to stimulate cellular turnover and strengthen your skin barrier. Youll see stronger, smoother, and firmer skin after a single nightand the results will get even better over time.

Dr. Barbara Sturm Hyaluronic Serum $255.00

Originally $300, now $255

Often considered the holy grail of luxury hyaluronic acid serums, its rare that youll find this stuff on sale (which means that your time to snag it is n-o-w). It contains three different molecular weights of hyaluronic acid, which penetrate and hydrate your skin at different levels, plus purslane, a natural ingredient rich in cell-renewal stimulating vitamin A and moisturizing vitamin E.

Cl de Peau Beaut La Crme $468.00

Originally $550, now $468

Believe it or not, the moisturizer encapsulated in this luxe-looking gold container is even more opulent than the packaging implies. It combines many of skin cares buzziest ingredientswrinkle-fighting retinol, hydrating hyaluronic acid, moisturizing squalane, antioxidant-rich silkwith a proprietary dark-spot-correcting blend, and leaves a luminous finish that only enhances its lavishness.

Augustinus Bader The Rich Cream PPC Cellular Renewal Rich Cream $145.00

Originally $170, now $145

Often referred to as the best skin care in the world the technology used in this moisturizer is truly unparalleled. It was initially developed to help with scarring in burn victims, but was brought to the wider market when developers realized how effective it was in aiding in overall skin health. So what makes it so special? It uses epigentic technology to deliver nutrients to specific parts of the cells to change the expression of their DNA, effectively catalyzing them to repair on their own, which improves the appearance of issues like scarring, discoloration, and wrinkles.

La Mer The Concentrate $178.00

Originally $210, now $178

Made with concentrated amounts of La Mers famed miracle broth (which is made from hand-harvested kelp) plus a stabilizing ferment that combines marine algae and seawater and holds three different types of sea minerals that help rejuvenate skin. When one of our editors tested out the concentrate for a full month, she saw her skin transform into a brighter, more even, and more hydrated version of itself, and deemed the product well worth the hefty chunk of change it will cost you.

Testament Beauty Turkish Coffee 3-in-1 Mask $58.00

Originally $68, now $58

For $58 (which, admittedly, feels like a steal compared to some of the other products on this list), this mask will give you triple beauty benefits in a single application. Finely-ground coffee seeds exfoliate and awaken skin, a combination of niacinamide and anti-inflammatory botanicals (think: safflower and sunflower) help to calm irritation, and ceramides and fatty acids aid in hydration and skin barrier strength. Its a scrub, a mask, and a moisturizer all in one, and can be used in place of multiple steps in your usual routine.

Elemis Pro-Collagen Oxygenating Night Cream $136.00

Originally $160, now $136

Your evening skin routine should be all about regeneration (fun fact: your skin repairs itself while you sleep), a process this moisturizer works to support. Its made with a blend of marine ingredients that infuse hydration, stimulate collagen production, and help ramp up your skins own antioxidant defenses, leaving you with a smoother, more supple complexion that will stay moisturized for 12 full hours after you apply.

MZ Skin Lift & Lustre Golden Elixir Antioxidant Serum $280.00

Originally $329, now $280

I count this as one of the few luxury serums in my own skin-care collection, and can confirm that its among the best that money can buy. Formulated by dermatologist Maryam Zamani, its made with a concentrated blend of stem cells, botanical extracts, and hyaluronic acid. According to clinical studies conducted by the brand, over the course of 30 days, the antioxidant-rich serum increases hydration by 25 percent, improves wrinkle depth by 16 percent, and enhances radiance by 38 percent. Personally, I love to use it as a part of my a.m. routine (or ahead of special occasions), because its gold flecks give my complexion a lit-from-within glow that looks gorgeous on its own or layered under makeup. Whats more? You can also dab it on your cheeks, brow bones, or Cupids bow as a stand-in for your go-to highlighter.

Check out the video below to find out which high-end products are a part of a dermatologist's own routine.

Want even more beauty intel from our editors? Follow our Fine Print Instagram account) for must-know tips and tricks.

Our editors independently select these products. Making a purchase through our links may earn Well+Good a commission.

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The Number 1 Serum in the U.S. Is on Sale at SaksAlong With Other Never-Discounted Buys - Well+Good

Kyoto A drug discovered through a method using induced pluripotent stem cells, or iPS cells, from sufferers of amyotrophic lateral sclerosis (ALS) was effective in stopping the progression of the neurological disease in five out of nine patients in a clinical trial, a research team at Kyoto University said Thursday.

While drugs that slow down the progression of amyotrophic lateral sclerosis, also known as Lou Gehrigs disease, have been used in the past, this is the first time that a chronic myeloid leukemia drug called bosutinib has been found to stop its progression, according to the team.

Haruhisa Inoue, a professor of neurology at Kyoto University leading the team, said that larger clinical trials will be needed to determine if the drug can be put to practical use, but We are now looking at the possibility of being able to control ALS with the power of science.

The team reproduced the disease by culturing iPS cells derived from the skin of patients into motor neurons. They then tested a series of drug compounds on the cells to find that bosutinib was effective in slowing down the progression of ALS.

The drug was administered for around three months to nine patients who were in the early stages of the disease and showing signs of deterioration. Progression of the disease stopped in five patients during the treatment period, while four patients continued to deteriorate at the same pace as before.

A comparison of the blood samples from both sets of patients showed that they had differing amounts of a protein unique to nerve cells before the drug was administered. Researchers plan to conduct clinical trials with larger groups while adjusting the dosage and other conditions in the future.

There are about 9,000 people in Japan who suffer from ALS. The disease causes motor neurons to progressively die, resulting in paralysis, with many patients requiring a ventilator to stay alive. Its exact cause is unknown, and no fundamental treatments have been established.

In a time of both misinformation and too much information, quality journalism is more crucial than ever.By subscribing, you can help us get the story right.

PHOTO GALLERY (CLICK TO ENLARGE)

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Drug that stops ALS progression found using iPS cells from patients - The Japan Times

Photo: Francis Collins, by NIH Image Gallery, via Flickr.

Francis Collins, Director of the National Institutes of Health (NIH),has just announcedhis intention to step down at the end of 2021 after more than 12 years heading the agency. The accolades are already rolling in. Noted evangelical political commentator David French, for example, rushed to praise Collins as a national treasure.

But Collinss real legacy is anything but praiseworthy, and the tendency of figures in the faith community to ignore his real record is far from admirable.

This year of all years should have made the truth about Francis Collins clear. Last month, documents were released suggesting that top National Institutes of Health (NIH) officials may haveliedwhen they denied that the NIH had funded gain of function research in Wuhan, China, that could have resulted in a pathogen that could infect humans.

After reviewing the documents, Rutgers University biologist Richard Ebright had a blistering response: The documents make it clear that assertions by the NIH Director, Francis Collins, and the NIAID Director, Anthony Fauci, that the NIH did not support gain-of-function research or potential pandemic pathogen enhancement are untruthful.

It was another blow to the reputation of Collins in a year when his agency has faced multiple scandals and controversies.

Among evangelical Christians and other people of faith in America, Collins has long been the equivalent of a rock star. But Collinss days of glory as a non-partisan role model, especially for the faith community, may be numbered and its not just because of the latest scandal over the origins of COVID-19.

In recent months, Collinss agency has become embroiled in controversies over its funding of stomach-churning medical experiments involving body parts harvested from aborted babies. The disclosures about the experiments followed Collinssrepealearlier this year of restrictions on the use of aborted fetal tissue in NIH-funded research.

Collins has also stirred controversy with his increasingly shrill attacks on unvaccinated Americans and his support for harsh mandatory vaccination policies that will require the firing of employees who choose not to be vaccinated with a COVID-19 vaccine.

The former head of the Human Genome Project, Collins catapulted to fame (and the cover ofTimeMagazine) in 2000 with the announcement of a working draft of the sequence of the human genome.He then became a hero to many Christians with the publication in 2006 of his bookThe Language of God, which recounted his journey from atheism to Christianity.

In an increasingly polarized national environment, Collins is one of the rare heads of a major federal agency to serve under both Republican and Democratic Presidents. Appointed by President Obama to head the NIH in 2009, Collins continued in that role under President Trump and now President Biden. He has regularly drawn praise from lawmakers on both sides of the aisle. At gatherings of evangelical Christians, he has been known to strum the guitar and sing worship songs and receive the adoration of attendees. At one 2019 eventit was reportedthat conference participants lined up for selfies with him.

In 2020, Collins wasawarded the prestigious Templeton Prize, worth more than $1.3 million, for his work integrating science and faith. Previous recipients of the prize have included Mother Teresa, John Polkinghorne, Charles Colson, and Aleksandr Solzhenitsyn.

Among secular as well as religious journalists, Collins often receives what verges on fawning treatment. A writer forThe New Yorkergushedthat Collins is a model of geek cool. He likes big, noisy motorcycles, and, despite a mild manner, he is famously unself-conscious. At the unlikeliest moments, he will strap on a guitar and accompany himself in song, often a tune he has composed for the occasion.

This year, however, Collinss reputation has taken continued beatings, not just because of evasive answers about the role of the NIH in gain-of-function research in China, but also because of publicity around NIH-funded experiments that many Americans, especially people of faith, would find horrific.

In May, reports surfaced aboutmacabre NIH-funded experimentsthat utilized body parts collected fromaborted human fetuses to createhumanized mouse and rodent models with full-thickness human skin.For the experiments, researchersat the University of Pittsburghcut into tiny pieces human fetal spleen, thymus, and liver organs and then transplanted the tissues and hematopoietic stem cells into irradiated mice. Researchers also sliced off skin from the scalp of the aborted babies and then grafted the fetal skin onto the mice. In the words of the scientists: Full-thickness human fetal skin was processed via removal of excess fat tissues attached to the subcutaneous layer of the skin, then engrafted over the rib cage, where the mouse skin was previously excised.

The body parts used for these experiments were harvested from aborted human fetuses with a gestational age of 18-20 weeks. By that age, an unborn baby hasbrain wavesand abeating heart. He canhear sounds and move his limbs and eyes, and his digestion system has started to work.In other words, the human fetuses whose organs were harvested for this NIH-funded research were well-developed tiny humans, not blobs of undifferentiated cells.

In August, an additional project funded by the NIH came to light thanks to documents obtained in a Freedom of Information Act lawsuit by Judicial Watch and the Center for Medical Progress. The lawsuit was filed after Collinss NIH dragged its feet in responding.According to Judicial Watch, the documents show that theNIH has provided nearly $3 million in tax dollars to support a fetal organ harvesting operation by the University of Pittsburgh in its quest to become a Tissue Hub for human fetal tissue ranging from 6 to 42 [!] weeks gestation.

David Daleiden, president of the Center for Medical Progress,commented: The NIH grant application for just one of Pitts numerous experiments with aborted infants reads like an episode ofAmerican Horror Story. Infants in the womb, some old enough to be viable, are being aborted alive and killed for organ harvesting, in order to bring in millions of dollars in taxpayer funding.

Daleiden furtherallegedthat NIH funding was used to underwrite labor induction abortions, where the baby is pushed out of the mother whole and then killed to obtain the desired tissues. In other words, the NIH was facilitating a process where babies, some of the age of viability, [are] to be delivered alive, and then killing them by cutting their kidneys out.

Francis Collins self-identifies as an evangelical Christian, and most evangelicals as well as faithful Catholics regard abortion as the destruction of innocent human life.

So how has Collins responded to these revelations? With horror? With a pledge to investigate? With a promise to stop taxpayer funding of such research?

Since early August, Ive repeatedly tried to get Collins to answer questions about these NIH funded experiments using aborted fetal organs and tissues.Does Collins support this research funded by his agency? Does he have any ethical objections to it? How does he personally justify the research given his religious convictions? I repeatedly emailed these and other questions to the media contacts for the NIH Office of the Director.

The response? His office has refused to answer.

But its not just NIH research involving humans that has been raising controversy this year. In recent months, Collinss NIH has come under fire for fundingabusive medical experiments on dogsthat critics say were unnecessary as well as barbaric. The experiments were funded by the NIH division headed by Anthony Fauci, but that division is under the ultimate oversight of Collins. In late August, 15 members of Congresssent a letterraising questions about the research.

Again, I tried to get a response from Collins about this latest controversy. Again, he refused to respond to questions.

Ironically, while Collins is AWOL when it comes to answering basic questions about the research his agency is funding, he is more than willing to speak out on other topics, especially COVID-19, where he is now becoming a polarizing figure to many because ofincreasingly shrill advocacy of compulsory vaccination as well as his demonization of those who choose not to take a COVID-19 vaccine.

At the end of April,Collins claimedthat he would not require NIH employees to get vaccinated, and he seemed to argue for a positive approach of selling the benefits of vaccines rather than demonizing the unvaccinated or engaging in finger-wagging. Yet by early August his public posture had changed. He was nowcheerleading for compulsory vaccine requirementsimposed by private businesses as well as enthusiastically overseeing compulsory vaccinations for the very workers at the NIH that he earlier said would not face compulsory vaccination.

After President Bidens speech in September declaringwar on the unvaccinated, Collins ramped up his own rhetoric.In an appearance on MSNBC after Bidens speech, Collins firstsuggestedunvaccinated people were selfish, declaring that this is really an occasion to think about loving your neighbor, not just yourself.

Collins then branded both unvaccinated people and politicians who dont favor vaccine mandates as killers on the wrong side of history. Dismissing their views as merely a philosophical political argument that is part of the culture war, Collins complained that this philosophical political argument is killing people, including, Im sad to say, some children. We have to get past this if we really have a future as a nation.

I would like to say particularly to those leaders who are on the wrong side of this, what Lincoln said one time, Collins declared. Citizens, we will not escape history. Do you want to be looked at in the lens of that backward look ten years from now and defend what you did when in fact, we are losing tens of thousands of lives that didnt have to die?

A question for Collins: Is attacking your fellow citizens (including many fellow Christians) as heartless killers because they disagree with you on either vaccinations or vaccine mandates an example of loving your neighbor?

Whatever one thinks about COVID-19 vaccinations, Collinss over-the-top rhetoric demonizing those he disagrees with as killers is beyond the pale, especially for someone who wears his Christianity on his sleeve. As I have writtenelsewhere, his rhetoric is also based on several falsehoods.

So just how far is Collins willing to go to push coercive medicine? Thats an interesting question.

In my home state of Washington, the governor has issuedan emergency orderthat will compel private religious schools and day care centers as well as other private businesses to fire employees later this month if they wont get vaccinated. While there technically is a route for religious exemptions, it is so narrow and onerous that many religious people may not qualify.

Its now being suggested in some states that discharged employeeswont be able to get unemployment benefits. Perhaps the idea is that if the unvaccinated dont die of COVID they can die of starvation instead.

As if that werent bad enough, the unvaccinated face the denial of medical care. Also in my home state, the University of Washington medical system is now apparently denyingorgan transplantsto patients who are unvaccinated, even if those patients have a credible medical reason for not having the vaccinations.

This is pure, unadulterated social Darwinism: Brand a whole class of people as biologically unfit (in this case, the unvaccinated) and then make sure they cant receive medical care, hold jobs, or basically survive. Heap scorn on them, demonize them as killers, and stir up hatred against them so other people begin to abuse them. If Collins is truly concerned about the judgment of history, he should read a little more widely about the sorry results of demonizing entire classes of people as the enemies of society.

Let me be clear: I am not arguing here about whether people ought to get COVID-19 vaccinations, or whether those vaccinations are helpful. For the record, depending on ones risk profile, I think vaccinations are in a persons best interest. The issue is whether in the name of vaccination people should be stripped of their livelihoods, denied medical care, and demonized as enemies of society. In any morally sane universe, the policies being proposed are as immoral as they are unprecedented.

So does Francis Collins endorse depriving unvaccinated people of their right to work and to support their families? Does he endorse denying them unemployment insurance? Does he go even further and endorse denying medical care to the unvaccinated?

I again asked Collins media relations staff for answers. Again, crickets.

Although Collins likes to tout his personal faith, he appears to have very little concern for any sort of conscience rights of fellows religious believers who disagree with him.After all, he dutifully served in a previous administration that repeatedly weakenedconscience protectionsfor medical workers opposed to abortion and thatviolated federal lawby turning a blind eye when California mandated abortion coverage in all private insurance plans.

It might also be noted that as late as December 2020, Collins was still urging thatmost churches should not meet in person, even implying that they shouldnt do sountil the summer or fall of 2021.

And his current promotion of compulsory vaccinations seemingly has no qualifiers. At least, he isnt talking about any.

Collins hasconcededthat various COVID-19 vaccines used cell lines originally derived from an aborted fetus in either their production or testing, which is one reason some people have moral qualms about the vaccines. Yet you wont find Collins advocating for the conscience rights of these people. In fact, Collins has been silent in the face of attacks on religious exemptions for vaccines.

Reasonable people can disagree about whether the use of abortion-derived cell lines is a moral deal-killer for the vaccines. But thats the point: Reasonable people candisagreeabout what violates their conscience. The test of support for religious liberty is not whether you only support the right of people who agree with you.

Not being willing to stand up for the conscience rights of others to determine their own medical treatment is not morally neutral. It is a moral failure. In the words of theCatholic Bishops of Colorado, A person is morally required to obey his or her conscience, and others should respect the right of others to follow their conscience.

Alas, for those who have followed Francis Collins closely over the years, his current failures of moral leadership come as no surprise. As I will discuss in an upcoming article, Collinss career has been one long testament to moral cowardice and confusion.

Here is the original post:
The Appalling Moral Failure of Francis Collins - Discovery Institute

Many brands manufacture eye creams for people who experience eye bags, dark circles, puffiness, and wrinkles. Some are allergy-safe and are also suitable for those who wear contact lenses.

This article explores what eye creams are and what to consider when buying a skin care product for the eye area. It also reviews a range of products available for purchase online and discusses some safety precautions.

Eye creams are cosmetic products specifically formulated for use on the delicate skin around the eyes. Eye creams can help hydrate and brighten the skin and sometimes improves its firmness.

The skin surrounding the eyes is thinner than the skin on the rest of the face. As a result, it may be more prone to dryness, the negative effects of environmental pollution, and sun damage.

Additionally, when a person blinks or uses facial expressions, the skin around the eyes can develop lines, wrinkles, and crows feet.

Some benefits a person may get from using eye creams may include:

However, there are some risks. For example, they may not be suitable for people who wear contact lenses. They could also irritate the skin,

The following are some factors individuals can look for when choosing an eye cream:

Our writer chose the following eye creams based on online research and customer review sites.

Please also note that the writer has not tested these products. All information in this article is research-based, and we do not intend to recommend certain products over others.

Size: 0.5 ounces (oz)

Skin types: All

Eminences eye cream contains snow mushroom, which reportedly pulls moisture into the skin and enhances its elasticity and barrier function.

Eminence states that the other ingredients promote hydration, reduce puffiness, and the appearance of under-eye bags.

In addition, the company claims it does not test its products on animals, and that this eye cream is soy and gluten-free.

Size: 0.5 oz

Skin types: Dry, normal, and sensitive

This SkinCeuticals product is a hydrating cream reportedly suited to individuals who have signs of aging around the eyes, such as crows feet and under-eye bags.

Its main ingredients include soy isoflavones, vitamin E, and silymarin. SkinCeuticals claims these ingredients help improve the skins firmness and nourish dry skin as they restore essential lipids.

Size: 0.33 oz

Skin type: Very sensitive skin

Avnes lightweight eye cream contains chamomile and dextran sulfate. According to the companys website, these ingredients may help with soothing sensitive skin and reducing puffiness.

This eye cream also includes hyaluronic acid to help hydrate the skin.

Size: 0.5 oz

Skin types: All

This Avne eye cream has four main ingredients, including retinaldehyde, hyaluronic acid, dextran sulfate, and thermal spring water.

The company claims these ingredients smooth fine lines and wrinkles, reduce the appearance of puffiness and dark circles, and soften the skin.

Size: 8.4 oz

Skin type: Sensitive skin

This product is a liquid toning lotion with a lightweight texture. Bioderma claims this cream provides a hydrating and refreshing effect.

The company also states that the ingredients in this cream reduce discomfort from dryness and lessen the appearance of visible redness.

The Bioderma website states that users can apply this lotion to their face and eye area after cleansing, and they can use the cream in the morning or evening.

Size: 0.5 oz

Skin type: Sensitive

According to customer reviews, Skin Authoritys Dramatic Eye Lift is a gel featuring a lightweight consistency. The company claims it is nongreasy, does not clog pores, and moisturizes the skin.

The product description states this cream helps lift sagging eyelids, lighten dark circles, and increase the skins firmness.

Its ingredients include evening primrose seed extract, grapefruit extract, and bergamot oil.

Size: 0.5 oz

Skin type: Dry skin

This eye gel aims to moisturize the skin and contains hyaluronic acid. Hyaluronic acid is naturally present in the skin and helps keep the skin hydrated by binding to water molecules.

Neutrogena claims its formula is noncomedogenic, does not clog pores, and has undergone testing by ophthalmologists.

Size: 0.5 oz

Skin type: Dry

The ingredients present in the Neocutis Lumire Riche eye cream include caffeine, sodium hyaluronate, and glycyrrhetinic acid. Neocutis claims these ingredients reduce puffiness, provide hydration, and brighten the skin.

In addition, the company says this product is suitable for people who wish to reduce the appearance of their wrinkles, crows feet, and dark circles.

The company has designed this cream to be noncomedogenic and states the product has also undergone testing by ophthalmologists and dermatologists.

Size: 0.5 oz

Skin type: Dry and delicate skin

Ormedic has formulated this eye gel to provide hydration to dry and delicate skin.

It contains quinoa extract, which reportedly helps reduce puffiness and the appearance of under-eye bags. The website also states that the product uses fermented black tea and plant stem cells, which feature anti-aging properties.

Size: 0.5 oz

Skin types: All

Revision Skincares DEJ eye cream aims to provide intense hydration and reduce the appearance of wrinkles, redness, and sagging.

According to the website, individuals should apply a pearl-sized amount to the under-eye area and along the orbital bone twice per day.

Size: 0.5 oz

Skin types: All

This natural cream formula uses chamomile, green tea, and ginkgo biloba leaf extract to minimize the appearance of puffiness, fine lines, and dark circles around the eyes.

Skin Authority states this product helps the skin retain moisture, while people can use it on their upper eyelid and brow line.

Size: 1 oz

Skin type: All types

This products main ingredient is hyaluronic acid. Although it is naturally present in the skin, its natural function does not involve hydrating the skin.

As a result, this formula uses three forms of hyaluronic acid, which the manufacturer combines with vitamin B5 to help plump the skin and deliver intense moisture.

Additionally, this product is reportedly lightweight, oil-free, and vegan-friendly.

The Ordinary also states it does not test finished products on animals.

Size: 0.5 oz

Skin types: All

This CeraVe cream contains ceramides to maintain the skins natural barrier and hyaluronic acid to retain the skins existing moisture.

CeraVe also uses niacinamide to calm the skin.

CeraVe uses Multivesicular Emulsion (MVE) technology to provide time-released delivery of particular ingredients in cosmetic creams. In this eye cream, MVE technology helps the skin stay hydrated throughout the day.

According to a 2016 evaluation, MVE techniques in skin care products have links to improved acne.

CeraVe claims this product has undergone testing by ophthalmologists. It is also allergy-tested and noncomedogenic. Additionally, the company states it is suitable for individuals with acne-prone skin.

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13 of the best eye creams 2021 - Medical News Today