Archive for January, 2020

Stem Cell Therapy Market Insights 2019, is a professional and in-depth study on the current state of the global Stem Cell Therapy industry with a focus on the Global market. The report provides key statistics on the market status of the Stem Cell Therapy manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. Overall, the report provides an in-depth insight of 2019-2025 global Stem Cell Therapy market covering all important parameters.

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The key points of the Stem Cell Therapy Market report:

The report provides a basic overview of the Stem Cell Therapy industry including its definition, applications and manufacturing technology.

The report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2019-2025 market shares for each company.

Through the statistical analysis, the report depicts the global total market of Stem Cell Therapy industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export.

The total market is further divided by company, by country, and by application/type for the competitive landscape analysis.

The report then estimates 2019-2025 market development trends of Stem Cell Therapy industry. Analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out.

The report makes some important proposals for a new project of Stem Cell Therapy Industry before evaluating its feasibility.

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There are 3 key segments covered in this report: competitor segment, product type segment, end use/application segment.

For competitor segment, the report includes global key players of Stem Cell Therapy are included:

Key Trends

The key factors influencing the growth of the global stem cell therapy market are increasing funds in the development of new stem lines, the advent of advanced genomic procedures used in stem cell analysis, and greater emphasis on human embryonic stem cells. As the traditional organ transplantations are associated with limitations such as infection, rejection, and immunosuppression along with high reliance on organ donors, the demand for stem cell therapy is likely to soar. The growing deployment of stem cells in the treatment of wounds and damaged skin, scarring, and grafts is another prominent catalyst of the market.

On the contrary, inadequate infrastructural facilities coupled with ethical issues related to embryonic stem cells might impede the growth of the market. However, the ongoing research for the manipulation of stem cells from cord blood cells, bone marrow, and skin for the treatment of ailments including cardiovascular and diabetes will open up new doors for the advancement of the market.

Global Stem Cell Therapy Market: Market Potential

A number of new studies, research projects, and development of novel therapies have come forth in the global market for stem cell therapy. Several of these treatments are in the pipeline, while many others have received approvals by regulatory bodies.

In March 2017, Belgian biotech company TiGenix announced that its cardiac stem cell therapy, AlloCSC-01 has successfully reached its phase I/II with positive results. Subsequently, it has been approved by the U.S. FDA. If this therapy is well- received by the market, nearly 1.9 million AMI patients could be treated through this stem cell therapy.

Another significant development is the granting of a patent to Israel-based Kadimastem Ltd. for its novel stem-cell based technology to be used in the treatment of multiple sclerosis (MS) and other similar conditions of the nervous system. The companys technology used for producing supporting cells in the central nervous system, taken from human stem cells such as myelin-producing cells is also covered in the patent.

Global Stem Cell Therapy Market: Regional Outlook

The global market for stem cell therapy can be segmented into Asia Pacific, North America, Latin America, Europe, and the Middle East and Africa. North America emerged as the leading regional market, triggered by the rising incidence of chronic health conditions and government support. Europe also displays significant growth potential, as the benefits of this therapy are increasingly acknowledged.

Asia Pacific is slated for maximum growth, thanks to the massive patient pool, bulk of investments in stem cell therapy projects, and the increasing recognition of growth opportunities in countries such as China, Japan, and India by the leading market players.

Global Stem Cell Therapy Market: Competitive Analysis

Several firms are adopting strategies such as mergers and acquisitions, collaborations, and partnerships, apart from product development with a view to attain a strong foothold in the global market for stem cell therapy.

Some of the major companies operating in the global market for stem cell therapy are RTI Surgical, Inc., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc., NuVasive, Inc., Pharmicell Co., Ltd., Anterogen Co., Ltd., JCR Pharmaceuticals Co., Ltd., and Holostem Terapie Avanzate S.r.l.

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Reasons to Purchase this Report:

* Estimates 2019-2025 Stem Cell Therapy market development trends with the recent trends and SWOT analysis

* Market dynamics scenario, along with growth opportunities of the market in the years to come

* Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects

* Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.

* Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years

* Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

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Stem Cell Therapy Market is Anticipated to Attain a Market Value of US$XX by the End of 2017 2025 - Fusion Science Academy

In a recent study published by MRInsights.biz, titled, Global Fish Skinning Machine Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2024, analysts offer a comprehensive overview of the industry for the forecast period 20192024.The report is based on complete research of the entire market, covering all its sub-segments through comprehensively thorough classifications. The report comprises of an in-depth investigation into the geographical landscape, industry size, demand, market share, technological advancements, regional gamut, and revenue estimations for the forecast duration. Further, it sheds light on the challenges impeding market growth and expansion strategies employed by leading companies in the market.

The Report At A Glance:

The report offers profound knowledge and extensive examination of the trends from the yesteryear and future. It provides the stakeholders, product owners, and marketing personnel a competitive edge in the market for the forecast period, 2019-2024. It focuses on economic developments and consumer spending trends across different countries. The report makes projections on which countries and regions will have a better standing in the years to come. The research study takes a closer look at the key driving forces, restraints, and opportunities responsible for determining the future of the market for the forecast period 2019-2024.

DOWNLOAD FREE SAMPLE REPORT: https://www.mrinsights.biz/report-detail/209775/request-sample

Attracting The Target Audience:

Firstly, the report aims to find out why customers need a certain product or service. The report looks at what problems a certain product and service can solve. The industry experts focus on the factors including audience type, target demographics, as well as other vital attributes about the target customer segment.

Global Fish Skinning Machine market competition by top manufacturers, with production, price, revenue (value) and each manufacturer including VMK Fish Machinery, , Uni-Food Technic, , Trio Machinery, , Baader, , NOCK Maschinenbau, , Cabinplant, , Maja-Maschinenfabrik Hermann Schill, , AGK Kronawitter, , Grupo Josmar, , Varlet,

On the basis of product, this report displays the production, revenue, price, market share, and growth rate of each type, primarily split into Automatic Fish Skinning Machine, Manual Fish Skinning Machine

On the basis of the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate for each application, including: Canned, Seafood Processing, Frozen Food, Other

This report studies the top producers and consumers, focuses on product capacity, production, value, consumption, market share and growth opportunity in these key regions, covering: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

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Reasons To Buy The Report:

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Autologous Stem Cell Based Therapies Market Report Analysis, Share, Revenue, Growth Rate With Forecast Overview To 2024 - Fusion Science Academy

SAN DIEGO--(BUSINESS WIRE)-- Allele Biotechnology and Pharmaceuticals, Inc. (President and CEO: Jiwu Wang, Ph.D., Allele), a San Diego-based private company, and Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., Astellas), through its Massachusetts-based subsidiary Astellas Institute for Regenerative Medicine (AIRM), entered into a licensing agreement to expand Astellas access to Alleles induced pluripotent stem cell (iPSC) technologies for various cell therapy programs.

Astellas, one of the largest pharmaceutical companies in Japan and already a leader in the development of cell-based therapeutics, has further dedicated to development of the field through its commitment to state-of-the-art iPS cell generation, modification, and manufacturing. iPSC lines can differentiate into all somatic tissue types, enabling a wide variety of therapeutic applications. The field of iPSC-derived cells has seen dramatic growth in clinical trials recently--the majority of the ~12 clinical trials around the world were initiated within the last 18 months and many more are upcoming.

Allele has been developing its core strength in reprogramming somatic cells into iPSCs with granted patents and the first commercial cGMP system it developed over the past 10 years. Allele also engages in more than a dozen different human tissue derivation activities through its own R&D efforts for internal programs and partnerships. To realize the unparalleled potential of iPSC, Alleles researchers and cGMP team are committed to setting up and validating cell assays for product quality control, genome analysis pipelines, closed-system automation for reprogramming, and machine learning in iPSC-related fields.

Under the terms of the new license agreement, Astellas will pay Allele upfront and milestones, product-based royalties, and potentially manufacture fees.

About Allele Allele Biotechnology and Pharmaceuticals was founded in 1999. In 2015, the company completed an 18,000 square foot state-of-the-art facility in San Diego for the production of GMP-grade human iPSC lines. The facility also supports the production of tissue-specific cells differentiated from these iPSCs, including pancreatic beta cells, neural progenitor cells, and cardiomyocytes.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200113005668/en/

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Allele and Astellas Enter into an Expanded License for the Development of iPSC Lines - BioSpace

Paul Olson wants everyone to know that he's thankful that Mayo Clinic saved his life ... twice.

That's why he purchased a high-profile billboard on South Broadway proclaiming that "I Beat Cancer Twice!" in big gold letters and thanking his doctors Larson, Kwon and Beahrs.

Actually, it's the second such billboard he put up in Rochester. The first was in 1997, five years after his first bout with prostate cancer.

"I have a perfect life thanks to Mayo. I would have been dead before I turned 50," said the retired 75-year-old Olson. "I think doctors need to get feedback from their patients. ... Everybody hears the gripes. Nobody hears the applause."

His story started in 1992, when he was referred to Mayo Clinic at age 47 and doctors discovered an advanced case of prostate cancer.

"A diagnosis like that is like looking at the end of a gun barrel," said Olson. "But the first thing they give you at Mayo is hope."

A treatment of surgery, chemotherapy and hormone therapy took care of the cancer. Olson, who was president of the Grand Rapids, Minn.-based Blandin Foundation, got on with his life. That meant travelling with his wife, running marathons, playing golf and eventually retiring.

Then in 2017, he ended up back at Mayo Clinic.

"I knew I had something funny going on," Olson said.

A special medical scanner unique to Mayo Clinic that he calls "magical" detected six tumors growing throughout his body. The prostate cancer had returned 25 years later.

Once again, his doctors at Mayo Clinic treated the cancer until no trace of the cancer was detectable in 2018.

"I just wanted to thank my doctors and Mayo for their extraordinary assistance ... for saving my life... again," he said.

Read more here:
Cancer patient shows his appreciation for Mayo Clinic on a billboard thank-you card - PostBulletin.com

The students of Moordale Secondary are growing up in season two of Netflixs breakout Sex Education.

When creator Laurie Nunn introduced her coming-of-age comedy about teenage nobody Otis Milburn (Asa Butterfield), who launches an underground sex clinic at his school, her characters inventive riffs on teen-com clichs that exist somewhere between the present and a nostalgic re-imagining of the John Hughes era were just beginning to awkwardly fumble their way through various sexual rites of passage.

The fumbling continues in season two, a way for Nunn to mine humor and relatability from this tale of a sensitive boy searching for his place (and libido) in the grand scheme of things. But theres a sureness of step now, for both Nunn and her colorful collection of misfits, who use the shows sophomore season to explore urges and fetishes and the kind of hormone-fueled existential crises grown-ups remember with detached amusement.

Season two of Sex Education delivers more heartfelt laughs and engaging storylines about a handful of fan-favorite characters, but it also pushes its storytelling, introducing new faces, confronting even more controversial issues, and asking viewers to grow with it. Before season two debuts Jan. 17, here is a refresher on the biggest storylines from season one and a look ahead at what to expect from the new episodes.

Old Dramas

The debut season ended with resolved conflicts and more than a few unanswered questions. After pining after school rebel Maeve Wiley (Emma Mackey) all season, Otis began a relationship with Ola (Patricia Allison), a fellow weirdo and the daughter of handyman Jakob (Mikael Persbrandt). Jakob and Otis mother, Jean Milburn (Gillian Anderson), were shacking up, but neither teenager knew thatyet. Just as Otis began to embrace his stunted sexual appetites, forgiving his mother for penning a book about his repressed urges and inability to pleasure himself, his romance with Ola kick-started his sex drive.

Meanwhile, Maeve, who spent much of season one struggling to survive on her own, was forced to say goodbye to her unreliable brother and her academic career after shouldering the blame for his illegal drug dealing at school. Eric (Ncuti Gatwa), who was tormented by school bully Adam (Connor Swindells) for much of the year, was left contemplating a confusing, violent hookup as Adams father, Mr. Groff (Alistair Petrie), sent him packing to military school.

Season two will check in on the status of Otis and Olas relationship and that of their parents as well as Erics romantic endeavors and Maeves life at the trailer park now that her business venture and friendship with Otis have been put on the back burner.

New Kids

With a new year comes new students, and a trio of characters make their mark early on in season two.

I still think that Otis very much leads us through the world, and he's still our protagonist, but I really wanted to be able to kind of get under the skin of some of our other characters, showrunner Nunn told The Hollywood Reporter about the shift in focus.

Expanding the world of Moordale means storylines focusing on fan favorites like Aimee (Aimee Lou Wood), Lily (Tanya Reynolds) and Jackson (Kedar Williams-Stirling). Newcomers include Rahim (Sami Outalbali), a French foreign exchange student who factors into Erics story in surprising ways; Viv (Chinenye Ezeudu), a brilliant young woman who shares a special bond with Jackson following a traumatic event; and Isaac (George Robinson), Maeves sarcastic new neighbor, who comes to her aid when her mother (Anne-Marie Duff), a former addict, pushes her way back into her daughters life.

In many ways, season two seems to bid farewell to childhood, untethering itself from former friendships and expected character arcs in favor of bolder storytelling. Otis seems content in his dalliance with Ola, and though he continues to dole out his brand of "sexpertise" to his fellow students, the days of bathroom confessionals are long gone. Eric, who went through an identity crisis in season one following a horrific assault, sports an enviable amount of self-confidence, even when lamenting his nonexistent love life. Maeve, whose cynicism masked her dreams and ambition, is forced to fight for what she wants for once.

The influx of new characters also means that Andersons soft-spoken sex therapist will take on a bigger role in season two, venturing from the safety of her home office and finding new clientele at Moordale Secondary after an episode of STI hysteria makes it painfully clear just how archaic the schools sex education curriculum is.

More Sex

Speaking of sex, theres certainly more of it, and in greater variety, in season two. Otis, who achieved the impossible by finally having an erection in the season one finale, is mastering the art of masturbation and learning how to please his girlfriend. Butterfield is given a big comedic moment in season two that involves a self-pleasuring montage set to the heavenly choir cover of the Divinyls' I Touch Myself that encapsulates everything this show does well before abruptly ending in the most nightmarish of ways.

This season also explores queer sex, using Eric and Rahims friendship to cover topics that feel taboo, even in these modern times, and forcing other mainstays to question their impulses in interesting, comical ways. There are fetishes and female orgasms galore, but there are also meditations on the aftermath of sexual assault, repressed desires and pregnancy scares.

Even More Questions

One thing Sex Education has also done well, and continues to shine at in season two, is letting its characters exist in a state of ambiguity. Yes, there are big payoffs, victories for underdogs, reconciliations for strained relationships, but Nunn poses as many questions as she answers by the time the eight episodes are over. Will Eric and Adam reunite? Will Maeve and Otis finally admit their feelings for one another? Will Jean write her book? Will Otis lose his virginity? Nothing is tied up too neatly this season, which might disappoint some, but its also proof that this series is fully dialed into the story its trying to tell, a messy, conversation-starting contemplation on the joys and pains of growing up thats as sincere as it is silly.

The second season of Sex Educationlaunches Jan. 17 on Netflix. Stay tuned to THR for additional coverage.

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'Sex Education' Primer: Where Things Left Off and What to Expect From Season 2 - Hollywood Reporter

BEAVER COUNTY (KDKA) A new center in Beaver County is focusing on helping the LGBTQ community.

Central Outreach Wellness Center in Aliquippa provides care while trying to break the stigma surrounding HIV and sexually transmitted diseases.

The clinic which opened Dec. 16, 2019 is the first of its kind for people in Beaver County, and the third location of its kind in the Pittsburgh region.

Alex Tatangelo, a nurse practitioner for the center, said the new location is in an area that lacks LGBTQ services.

Theres a lot of fear in that community still and theres a lot of fear going into a doctor and talking about things that may be concerning to them, Tatangelo said.

The clinic has STD testing, Hepatitis C care and hormone replacement therapy.

For the LGBTQ community, we offer PrEP, which keeps you protected for acquiring HIV, Tatangelo said. We offer HIV care and primary care for individuals who are already HIV positive.

What makes this center even more unique is it shares office space with the LGBTQ agencies PRISM and Project HOPE.

We are a safe space for LGBTQ youth and their allies to come and be themselves, PRISM founder Jaci Palmer said.

Palmer said her goal is to make LGBTQ youth feel like they matter and cut down on teen suicide.

She says LGBTQ teens are five times more likely to commit suicide than their heterosexual friends.

And as for David Adkins, whos HIV positive and the founder of Project HOPE, his goal is to create awareness for people impacted by HIV and AIDs.

He does that through outreach, support groups and fundraisers.

Ive lost a lot of friends to HIV and AIDs, and why am I still here? Theres a reason Im here to do what I can do, Adkins said.

Central Outreach Wellness Center has offices in Allegheny and Washington counties.

The center accepts appointments and walk-ins.

Originally posted here:
We Are A Safe Space: Center In Beaver County Aiming To Help LGBTQ Community And Break Stigmas - CBS Pittsburgh

WAUSAU, Wis. (WZAW) -- Approaching middle age often brings stress and fear, and if you're a woman, you can be at an increased risk of developing a mental illness like clinical depression and anxiety.

Judy Lemke, a professional counselor and clinical social worker from Behavioral Health Clinic joined the Deep Bench on Thursday to discuss the topic. She said as a woman, you cant escape menopause and it comes with changes both physically and emotionally.

The estrogen levels are the things that decrease the most and fluctuates, but thats not the only hormone that gets out of balance. So does dopamine, cortisol and the feel-good drugs. That can bring about mood changes and can create anxiety and depression.

Lemke said when those changes happen, it can make it very difficult to control your emotions.

The most common, you might feel irritable, you might feel very sad. You might be teary one minute and laughing the next, kind of feel like youre all over the map and not know what to expect, she explained.

Lemke add that its not something that everyone can understand, especially if you arent experiencing the same changes.

She went on to explain that if you have a history of postpartum depression, significant PMS or clinical depression prior to menopause, youre most likely to experience a depressive episode during menopause.

But there doesnt seem to be a real specific, scientific proof that you will become depressed or anxious. And theres a lot of women, about 25% that make it through menopause without any type of effects on their emotions, other than the physical effects.

Excerpt from:
Deep Bench: How aging and menopause in women can impact mental health - WSAW

We're taught the basics about the female body in sex ed. But after milestones for women like getting your period and giving birth, many women feel uninformed about the basics of their reproductive system -- especially as they age.

Just like aging is visible outside of your body, many dont realize their internal organs are also going through a transition.

Dr. Jennifer Ashton, ABC News' chief medical correspondent, breaks down four things all women should know about their reproductive system.

"When we look down the road, it should be with optimism and understand that everyone will get through it," Ashton said. "Just like we all got through puberty."

First, its important to understand that the full female reproductive system is more than just the vagina and ovaries.

"Were talking about the whole external and internal urogenital system," Ashton explained, which also includes the bladder, urethra and vulva.

The ovaries are responsible for the production of the hormones estrogen, progesterone and a portion of the bodys testosterone, all of which decrease as a woman approaches menopause.

Estrogen is a major hormone responsible for affecting change in a womans body.

"Everything in the pelvic, genital area is affected by a decrease in estrogen levels," Ashton said. "Dropping estrogen levels are responsible for hot flashes, vaginal dryness, weakening of bones -- you name it and estrogen is likely involved."

A decrease in estrogen levels in the pelvic and genital areas causes the tissues to become weaker and more fragile. This can make this region of the body more susceptible to injury and infection.

Meanwhile, a decrease in progesterone levels can affect mood and also lead to memory loss, while a decrease in testosterone can be related to a decrease in a womans libido.

"A lot of people dont realize that women have testosterone as well," Ashton said. "That drop in testosterone level in a woman is responsible for the dreaded, 'I dont understand why I am gaining weight while Im still exercising and eating well.'"

As the strength and elasticity of muscles in the pelvic region decrease, problems such as incontinence and prolapse of pelvic organs, such as the bladder, uterus and rectum, may occur. A prolapse is when organs fall down or slip out of place

"Any of those organs can prolapse or protrude through the vagina, in most severe cases, outside of a womans body, but most of the time just into the vagina," Ashton said.

Women who have had many vaginal deliveries can be at higher risk of pelvic organ prolapse, but chronic coughing and obesity are also associated causes. Though women of any age can experience issues related to a weak pelvic floor, it is more common in older women.

"The most common symptom is the sensation of pressure," Ashton explained. "Some women will feel a lot of pelvic pressure and some women might have to urinate more frequently."

She notes that medical devices, such as the Yarlap, can strengthen and tone pelvic floor muscles, helping women regain control over their bladder and work to prevent pelvic organ prolapse.

"One thing women should focus on is the importance of the pelvic floor when it comes to the reproductive system," MaryEllen Reider, co-founder of Yarlap, said. "Its a muscle that hasnt gotten a lot of recognition and women shouldnt be ashamed to talk about any issues."

Menopause is defined as one year without a menstrual period.

According to the Mayo Clinic, menopause can happen in women in their 40s or 50s, but the average age is 51 in the U.S. Ashton explained that factors such as family history, smoking and medical conditions can affect the age when a woman begins through menopause.

Common symptoms leading up to menopause include mood swings, memory loss, hot flashes, an increase in body fat, a decrease in bone density and irregular vaginal bleeding, but not all women will experience all of the symptoms.

"In some women, as they approach menopause, their period will just fade off into the sunset and bleeding will completely stop," Reider said. "In other women, bleeding can become more irregular. In some cases, heavier and closer together. There is really no way to predict, it's very individual."

Although menopause is something many women dread, Ashton said women have something to look forward to.

"For many women it might feel like the worst thing ever, but there are treatments and ways to manage it," she said. "Women are now living a third of their life after menopause and those can be really vital and vibrant years."

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What women should know about their reproductive system as they age - ABC News

At-home finger pricks used to be synonymous with diabetes. Now, anyone can prick their finger at home to test for virtually any condition they want.

Lab tests and disease screenings historically involve making a doctor's appointment, enduring a couple hours in a clinic and waiting weeks to find out your results. Direct-to-consumer health companies have changed that with mail-order kits that test for everything from Celiac disease to nutrient deficiencies, all with only a finger prick or a saliva sample.

You can test an entire hormone panel to discover the cause behind chronic symptoms -- like daytime fatigue, digestive issues and headaches -- or test for a single compound, such as hbA1c for diabetes.

While you shouldn't use these at-home health tests as a diagnostic tool alone, they can help you avoid unnecessary trips to the doctor if you get negative results -- or spark an informed discussion with your primary care physician if you get positive results.

Remember that these at-home health tests aren't perfect, but the results you get can give you insight to a health concern you've been struggling with. For example, if you've been battling poor sleep and digestive issues, you might have a food intolerance. An at-home allergen-specific test can be the first step in modifying your diet or seeking treatment from a nutrition professional.

With that, we round up eight of the best at-home diagnostic tests for different health concerns.

Chances are you know at least one person who eats a gluten-free diet, whether they have a diagnosed gluten allergy or not. Many people have health concerns about gluten ranging from minor sensitivities to full-blown Celiac disease.

If you suspect you have Celiac disease, the Imaware Celiac Disease Screening Test is a good place to start -- the kit tests for an antibody called tissue transglutaminase (tTG) antibody, or tTG-IgA. This enzyme repairs damaged tissues in your body, but people with Celiac disease often make antibodies that destroy tTG-IgA.

At $99, this at-home Celiac screening is likely to be less expensive than visiting a doctor for a Celiac test, depending on your insurance. If you get positive results, you can follow up with a physician. The only caveat -- you'll need to consume gluten regularly leading up to the test, so if you typically have a negative response to foods with gluten, you might endure a few uncomfortable days.

Read more: On a gluten-free diet? This search engine will make life easier

If you often find yourself keeling over and battling cramps after meals -- or dealing with less severe symptoms such as chronic fatigue and joint aches -- you might have food sensitivities to something you eat on a regular basis.

Check for 240 food items with the Test My Allergy Core Test, an allergen-specific immunoglobulin E (IgE) test. Your body makes IgE antibodies to protect your organs and tissues from viruses, bacteria and allergens -- they look different depending on what they are reacting to, which is how an allergen-specific IgE test can pinpoint what you're allergic to.

Note that you may be better off with a general IgE test that Test My Allergy also offers, which measures the overall level of IgE antibodies in your blood. This is because a high percentage of allergen-specific IgE tests for food intolerances can yield false positives. If you get positive results on either type of at-home test, you should take the results to your primary care doctor for further discussion.

No one enjoys talking about their sexual health, even with a doctor, when things go wrong. If you think you might have a sexually transmitted disease (STD), an at-home test can be a less awkward first step to getting treated.

The Complete 10 kit by LetsGetChecked tests for the 10 most common sexually transmitted infections, including chlamydia, gonorrhea, herpes and syphilis. For this test, you'll collect both a blood and urine sample and mail them back on the same day.

If you get positive results for any infection, see a doctor right away to begin treatment. Also, remember that many STDs don't show any symptoms, so don't rely on symptoms as a sign that you need to get tested: If you're at all suspicious, talk to your partner about the possibility of an infection.

The EverlyWell Men's Health Test checks for levels of cortisol, dehydroepiandrosterone (DHEA), free testosterone and estradiol, four key hormones that can affect mood, weight and muscle mass, energy and libido in men.

Collect a saliva sample shortly after you wake up and mail the sample back to EverlyWell the same day. You'll get a personalized, physician-reviewed report of your levels of each hormone and how those hormones relate to your current symptoms -- if you've been feeling chronically tired and weak or experiencing a low sex drive, for example, this test can help pinpoint what's wrong.

Via a finger prick and saliva sample, the EverlyWell Women's Health Test checks for 10 hormones thought to affect energy, mood, weight, fertility, sex drive, sleep, skin health, muscle and joint health, headaches, bloating and indigestion, hair health and more in women.

At $399, it's not a cheap kit, but it could help you discover if wacky hormone levels are the culprit behind your daily fatigue, poor concentration or other symptoms. And a full hormone panel at a doctor's office might cost you upwards of $1,000 depending on your insurance.

When your report comes back with information about your hormones and what the detected levels mean, you can decide whether it's worth seeing a professional about your symptoms in person.

Hormones aren't the only things that can cause seemingly unexplained fatigue, disturbed sleep, low libido or poor productivity. If you aren't getting enough essential vitamins and minerals from your food, nutrient deficiencies can spur those same symptoms.

This Nutritional Deficiency Test from 5Strands looks for 115 nutrients with a hair analysis, an incredibly accurate method of testing often used for DNA and drug tests. You'll find out if you're deficient in any amino acids, fatty acids, trace minerals and vitamins, as well as certain hormones (like melatonin) and compounds that affect your metabolism.

This comprehensive at-home hormone panel tests for five hormones, but what's more interesting is that it tests for your cortisol levels in the morning, afternoon, evening and night. Cortisol is often called the "stress hormone" because of its known role in physiological stress -- cortisol surges when you undergo a fight-or-flight response, but it's also important for exercise responses, controlling blood sugar, regulating your metabolism and balancing inflammation.

Cortisol naturally fluctuates throughout the day, but if you have unexplained symptoms at certain times during the day or night, the HealthConfirm Hormone Vitality Complete test can help uncover the cause. For example, cortisol levels should naturally reduce to their lowest at night. If you can't sleep -- and you know it's not caused by too much blue light or other sleep-disturber -- unusually high nighttime cortisol could be the offender.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

See the article here:
8 at-home health kits to test for Celiac disease, fertility and more - CNET

Theyre not at home, she said. They are not sleeping well, because things are buzzing and bumping at night. Theyre loaded up with a whole bunch of medicines. Its not a restful place to be.

That disorientating, sleep-depriving atmosphere likely is the reason that hospitals and intensive care units in particular are common places for the phenomenon known as sundowners syndrome, said Greminger, an Essentia Health internist and faculty member at the University of Minnesota Medical Schools Duluth campus.

Also known as sundown syndrome, sundowning syndrome or just plain sundowning, its the emergence or worsening of agitation (or) other types of potentially problematic, challenging behaviors that occur in the late afternoon or early evening, said Joseph Gaugler, director of the School of Public Health Center on Aging at the University of Minnesota.

Some of the behaviors can include confusion, anxiety, aggression, ignoring directions and pacing or wandering, according to Dr. Jonathan Graff-Radford, a neurologist at the Mayo Clinic in Rochester whose specialties include Alzheimers disease and dementia.

Sundowning is by far most common among people who have forms of cognitive impairment or dementia, the experts said, although it doesnt necessarily accompany dementia.

Sometimes we hear from patients and their families that sundowning was one of the earliest symptoms, Graff-Radford said. Patients who have "dementia with Lewy bodies" seem to be particularly susceptible, he added.

It often does, the experts say. Also, its very common in older adults who are living in nursing homes or assisted living, Greminger said.

The unfamiliar surroundings seem to be a trigger.

Any change in environment, whether it be a hospitalization or a move to a new living environment, can prompt this, Graff-Radford said.

The short answer: No one knows. Theres actually not much research on sundowning, Gaugler said.

Some theorize that its a disorder in the circadian rhythm, Greminger said. Another theory in the early stages, Gaugler said, is that its related to the hypothalamic pituitary adrenal axis (HPA) and its production of the stress hormone known as cortisol.

Again, the answer isnt known. According to Alzheimers Association data from 2006, anywhere from 2.4 to 25% of patients with Alzheimers also have sundowners, Greminger said.

Its certainly a well-known, if not well-understood, phenomenon.

I would say every hospitalist has seen it, Greminger said. Its not uncommon.

No. Sundowning syndrome is exactly that, Gaugler said. Its this unique pattern of symptoms that happens at that time late in the afternoon, earlier in the evening.

But its similar to delirium, Greminger said. Delirium, which isnt limited by time of day, is a confused state that may be induced by medical treatment.

Delirium tends to be brief; hours or days, she said. Its not a long-term pattern. It fluctuates during the course of the day.

Patients symptoms often do diminish when they return home to a familiar environment, Graff-Radford said. But maybe they dont get quite back to where they were before.

Its important to not just assume the problem will go away when your loved one comes home, Gaugler said. I dont think its as simple as well get them out of the hospital and well get them home; its all great, he said. There does need to be some ongoing care management.

Hospitals should try to help patients achieve somewhat normal sleep patterns, Greminger said. Maybe not doing labs during the middle of the night; not taking vital signs during the middle of the night.

She disagrees with telling patients to leave their glasses and their hearing aids at home.

Im not going to say that hospitals or nursing facilities have never lost them, Greminger said. That happens. But in reality, having those things, having the ability to hear like you would at home, having the ability to see like you would at home, having proper adaptation reduces the risk.

Research suggests melatonin therapy, light therapy and moderate exercise may have benefits for those with sundowners, Gaugler said.

So can turning off TVs in the evening.

Ive been in many nursing homes where the TVs always on blasting through dinnertime and such, and these kinds of distractions I dont think are helpful for behaviors and people with memory loss, he said.

Both Greminger and Gaugler gave two thumbs down to antipsychotic medications, at least as a first line of treatment.

They have a number of very adverse effects and consequences, Gaugler said. Too often theyll be used as chemical restraints by nursing homes. Thats not good for the quality of life, and its not good for the person.

If you can place familiar objects in the room such as pictures of family members, you can lower the risk of your loved one developing sundowners while in the hospital or nursing facility, Graff-Radford said.

Or bring yourself.

Having someone familiar around them could be very helpful, Greminger said.

Also, Graff-Radford said, if you have a loved one with dementia who is going into the hospital for even a routine procedure, you should make sure the medical team is aware of the dementia diagnosis.

Read this article:
Why late afternoon, evening in hospitals can be the worst time of day - Brainerd Dispatch

INDIANAPOLIS (WTHR) I remember distinctly the moment I first told my wife we were moving to Indianapolis for a great new opportunity at WTHR. There was elation, followed by her biggest concern the weather!

Even though my wife was born and spent some of her youth in the Midwest, she quickly grew tired of the cold, overcast skies and snow. We were probably spoiled after spending years in the south, between stops in Texas and South Carolina. We both crave sun and warmth, but the reality is, we love Indiana!

So how do you overcome living in the Midwest during December through March?

Well, psychologists have diagnosed it as "Seasonal Affective Disorder," or "SAD" for short.

Experts define it as a type of depression related to the change in seasons. For most, the symptoms typically start in late fall and continue through winter.

Typical symptoms include:

However, there is hope.

I spoke to Dr. Danielle Henderson, a clinical psychologist with IU Health, about ways to cope. Some of the tips are simple enough: get outside, take a walk, sit by a window if it's too cold to go out, make plans or make yourself go out with family and friends. She says if those don't do the trick, then it's definitely time to schedule an appointment with your primary care physician to talk about your mood and symptoms.

According to the Mayo Clinic, most experts say that shorter days and less daylight in winter cause a chemical change in our brain. The sleep hormone melatonin might play a part too. Doctors say the body makes more melatonin when it's dark, and since it's darker longer in winter, you may have more melatonin in your system, which could cause some fatigue. The brain chemical serotonin could play a part too. Reduced sunlight can cause a drop in it, which could cause depression.

If they deem you do indeed have SAD, then obviously there are medications, even mild anti-depressants that can be prescribed, according to Dr. Henderson.

"With Seasonal Affective Disorder, we might notice these symptoms kind of staying around a little bit later into the winter and then hopefully starting to improve around the springtime when our weather and seasonal changes do happen," Dr. Henderson said.

However, she said if symptoms still last through spring and summer, then speaking to a trained professional is paramount. Also, if a friend, family member or co-worker comes to you to talk about their concern, they may have SAD. Dr. Henderson said to be sensitive to that. Listen to them. Be a support system. Offer counsel.

For Christine Winger of Fishers, she admits she's suffered from the winter blues since early adulthood.

She's never been diagnosed with SAD, but she definitely notices change this time of year.

"It really hits January, February," Winger said.

Winger is a school counselor at Carmel Middle School, so she's not shy about opening up regarding her mood in the winter time and how the the change of season affects her.

"The lack of sun, lack of being able to get outside...I've noticed that I've just struggled with like lower energy levels. I feel like I'm more irritable," Winger said.

Experts estimate SAD impacts about 10 million Americans. They say another 10 percent to 20 percent may have mild SAD, which is most likely the category Winger and my wife fit in.

Research shows SAD is four times more common in women than in men. So, Winger has found ways to cope with the winter blues that work for her.

"Definitely running and exercise is the biggest thing that helps me get through it," Winger said.

She runs at least a mile a day. It's a challenge she enjoys. It gets her outside, breathing fresh air and sometimes, the sun is even out!

Dr. Henderson agrees that's a great way to conquer the winter blues but knows that each case can be unique.

Find healthy and safe ways that work for you!

Again, it's important to remember to never be afraid to talk to someone.

Remember, we at WTHR are proud partners with Community Health Network. If you or someone you know is struggling with depression or suicidal thoughts, you can find resources for assistance by clicking here.

Excerpt from:
Beating the 'Winter Blues' - WTHR

The more sex you have in middle age, the later youll enter the menopause. Thats about the gist of recent headlines after a new study, that followed 3,000 middle aged women for a decade, found those having weekly sex went through the menopause later than those having it less than once a month.

One of the study authors, Megan Arnot, who is studying for a PhD at University College London, said of the studys findings:Theres a use it or lose it kind of thing going on.

However,as a menopause doctor, I think we should take these findings with a pinch of salt. Partly because the study involved questioning women about their sex lives, which always raises the question of how truthful and accurate the answers are. And secondly because the issue of menopause and sex is such a complex one.

Rather than weekly sex delaying the menopause, it could be that women who are in the early stages of the menopause start to have less sex. And this could be for several reasons.

None of the women who took part in the study had yet entered the menopause. However, 46per cent were beginning to experience symptoms, such as changes in their period and hot flushes, which means they were very likely to be perimenopausal, which is the transitional stage leading up to the menopause. Oestrogen and testosterone, two hormones that begin to dip as you approach the menopause and then decline as you go through it,can bevery important for self esteem, self worth, weight gain, and body image. Which, as every woman knows, are very important when it comes to how much sex you feel like having.

See the rest here:
The truth about sex and the menopause, by a menopause doctor - Telegraph.co.uk

The Fulton County Health Department has scheduled the following health clinics and services.

CANTON The Fulton County Health Department has scheduled the following health clinics and services. Please call the number listed with each service for an appointment or more information.

Maternal child health: Health screenings, WIC nutrition education and supplemental food coupons for women, infants and children. To make an appointment or for more information call 647-1134 (ext. 254). For Astoria clinic appointments call 329-2922.

Canton - Clinic - Monday, Jan 13 - 8-4 - Appt needed

Canton - WIC Nutrition Education - Tuesday, Jan 14 - 8-4 - Appt needed

Canton - Clinic/Immunizations - Wednesday, Jan 15 - 8-4 - Appt needed

Astoria - Clinic, WIC Nutrition Educ. - Wednesday, Jan 15 - 9-3 - Appt needed

Canton - Clinic - Thursday, Jan 16 - 8-4 - Appt needed

Adult Health Immunizations: Various vaccines are available. There is a fee for immunization administration. Medicaid cards are accepted. To make an appointment or for more information call 647-1134 (ext. 254).

Canton - Immunizations - Wednesday, Jan 15 - 8-4 Appt needed

Other times available by special arrangement at Canton, Cuba and Astoria.

Blood Lead Screening: Blood lead screenings are available for children ages one to six years. A fee is based on income. To make an appointment or for more information call 647-1134 (ext. 254). For Astoria appointments call 329-2922.

Canton - Clinic - Wednesday, Jan 15 - 8-4 - Appt needed

Family Planning: Confidential family planning services are available by appointment at the Canton office for families and males of child-bearing age. Services provided include physical exams, pap smears, sexually transmitted disease testing, contraceptive methods, pregnancy testing, education and counseling. Services are available to individuals of all income levels. Fees are based on a sliding fee scale with services provided at no charge to many clients. Medicaid and many insurances are accepted. After hours appointments are available. To make an appointment or for more information call the 647-1134 (ext. 244). *Program funding includes a grant from the US DHHS Title X.

Pregnancy testing: Confidential urine pregnancy testing is available at the Canton and Astoria offices. This service is available to females of all income levels. A nominal fee is charged. No appointment is needed. A first morning urine specimen should be collected for optimal testing and brought to the health department. Services are provided on a walk-in basis on the following days each week:

Canton: Every Wednesday & Thursday, 8-3:30 (for more information call 647-1134 ext. 244)

Astoria: Every Wednesday, 9-2:30 (for more information call 329-2922)

Womens Health: A womens clinic for pap tests, clinical breast examinations and vaginal examinations is available by appointment. There is a nominal fee for this service. Medicaid cards are accepted. Financial assistance is available for a mammogram. Cardiovascular screenings may be available to age and income eligible women. To make an appointment or for more information call 647-1134 (ext. 244).

Mammograms: Age and income eligible women may receive mammograms at no charge. Speakers are available to provide information to clubs and organizations. For more information or to apply for financial assistance, call 647-1134 (ext. 254).

Mens Health: Prostate specific antigen (PSA) blood tests are available for men for a fee. To make an appointment or for more information call 647-1134 (ext. 224).

Canton - Clinic - Monday, Jan 13 - 8-12 - Appt needed

Sexually Transmitted Disease (STD) Clinic: Confidential STD and HIV testing services are available by appointment to males and females at the Canton office. Services include physical exams to identify STDs, a variety of STD testing, HIV testing, education, counseling, medications and condoms. There is a nominal fee for services. Services are available to individuals of all income levels. Medicaid cards are accepted. To make an appointment or for more information call 746-1134 (ext. 224).

HIV Testing and Counseling: Confidential HIV testing and counseling services are available by appointment through the sexually transmitted disease (STD) clinic at the Canton office. To make an appointment or for more information call 647-1134 (ext. 224).

Tuberculosis (TB) Testing: TB skin tests are available at no charge by appointment. To make an appointment or for more information call 647-1134 (ext. 254).

Blood Pressure Screenings: The Fulton County Health Department provides blood pressure screenings at no charge on a walk-in basis during the following times:

Canton - Screening - Monday, Jan 13 - 8-4 - Walk in/Room 108

Cuba - Screening - Monday, Jan 13 - 8-12 - Walk in

Astoria - Screening - Wednesday, Jan 15 - 9-12 - Walk in

Health Watch Wellness Program: The Health Watch Program provides low cost lab services. Through this program adults can obtain venous blood draws for a variety of blood tests. Blood tests offered without a doctors order Comprehensive Metabolic Panel (CMP), Complete Blood Count (CBC), Lipid Panel, Prostate Specific Antigen (PSA) test, Hepatitis C test, and Thyroid Stimulating Hormone (TSH). A wide variety of blood tests are also available with a doctors order. There is a charge at the time of service. To make an appointment or for more information call 647-1134 (ext. 254).

Canton - Clinic - Monday, Jan 13 - 8-12 - Appt needed

Dental Services: The Dental Center offers a variety of basic dental services to children and adults. An appointment is needed. Medicaid and Kid Care cards are accepted. To make an appointment or for more information call 647-1134 (ext. 292).

Link:
Health Department announces services for the week of Jan 13 - Canton Daily Ledger

A new study helps illuminate how weight loss can contribute to the remission of type 2 diabetes and how putting pounds back on can cause the disease to return.

The findings, published in December 2019 in Cell Metabolism, suggest that individuals with type 2 diabetes who achieve remission after weight loss may relapse if they regain weight in part because this leads to an accumulation of fat in the liver.

Researchers examined data on 57 overweight and obese people with type 2 diabetes who participated in a prior study, which was published in March 2019 inThe Lancet Diabetes & Endocrinology. Those study authors goal was to see if following a low-calorie diet for three to six months would help participants lose at least 15 kilograms (about 33 pounds) and lower their blood sugar levels enough to achieve remission of diabetes. Researchers checked participants weight, blood sugar, and fat levels in the liver and pancreas after 5, 12, and 24 months.

After five months, 28 people achieved the targeted weight loss and diabetes remission. By the end of two years, however, 13 of them had relapsed. People who achieved lasting remission lost more weight initially, kept more weight off than those who relapsed, and had less fat in the liver and pancreas by the end of the study.

Excess calorie intake over many years will initiate vicious cycles of fat accumulation within both the liver and the pancreas that eventually causes diabetes, says lead study author Ahmad Al-Mrabeh, PhD, of Newcastle University in the England.

Decreasing liver fat can lead to remission of diabetes, Dr. Al-Mrabeh says. When you do, he adds, the liver stops sending out excess fat to the rest of the body, and therefore pancreas fat levels decrease.

RELATED: Study Suggests How Much Weight Loss Is Needed to Put Diabetes in Remission

Type 2 diabetes is a multifactorial disease, with genetics and lifestyle both contributing to risk. The disease is also associated with obesity and inactivity, and develops when the body cant effectively use the hormone insulin to regulate blood sugar, according to the World Health Organization. The pancreas produces insulin, and must increase production when the body doesnt use this hormone efficiently. Yet theres a limit to how much insulin the pancreas can make, and diabetes results when the pancreas can no longer keep up with the bodys insulin demands to keep blood sugar levels in check.

Left untreated, type 2 diabetes can increase the risk of kidney failure, heart attacks, strokes, blindness, lower limb amputations, and other potentially life-threatening complications.

Regular exercise, eating well, and maintaining a healthy weight can help prevent type 2 diabetes. These lifestyle habits can also help lower blood sugar and minimize complications when people do develop diabetes, according to the World Health Organization.

While weight loss has long been linked to diabetes remission, the current study offers fresh insight into how the two are related, says senior study author Roy Taylor, MD, also of Newcastle University.

When people cut calories, the body will get the energy it needs by burning up fat thats stored under the skin, Dr. Taylor says. By contrast, when people consume too much food, these fat stores fill up and then excess fat starts accumulating in the liver.

Excess liver fat will lead to higher supply of fat to all tissues, including the pancreas, Taylor says.

When fat builds up in the pancreas, this interferes with insulin production, making it harder for the body to regulate blood sugar and contributing to diabetes. When people achieve diabetes remission through weight loss, regaining weight can restart the process of fat accumulation in the liver, and then the pancreas, and lead to relapse, according to the study.

RELATED: Which Types of Diabetes Can Be Put in Remission?

At the start of the study, all of the participants tended to have higher A1Cs. A1C is a blood test used to diagnose diabetes and determine how well blood sugar is being controlled. It shows the percentage of hemoglobin (a molecule on red blood cells) that is coated with sugar, and reflects average blood sugar levels over two to three months. Readings above 6.5 signal diabetes, according to the Mayo Clinic.

People who never achieved remission in the study started out with more severe diabetes, with average A1C readings of 7.9, compared with average A1C readings of 7.4 among people who did experience remission.

Weight loss initially brought about similar reductions in the percentage of fat in the liver and pancreas for people who achieved diabetes remission, as well as for those who didnt.

After five months, people in remission had 3.4 percent liver fat compared with 2.6 percent in people who didnt achieve remission but this difference wasnt statistically meaningful.

Participants also experienced similar decreases in fat levels in the pancreas after five months: a decline of 0.91 percentage points among people who went into remission and 0.17 points for those who didnt. This difference also wasnt statistically meaningful.

By the end of the two-year follow up period, though, pancreatic fat levels had dropped by 1.65 percentage points among people with sustained remission and only 0.51 percentage points among those who didnt.

One limitation of the study is that it was small, and researchers based their two-year analysis on only 20 people who sustained remission and 13 people who relapsed.

Its also not clear from the study whether people took medication for diabetes, what they ate, or how much they exercised factors that can influence whether people achieve remission.

It would have been helpful if the study included more information about how weight loss was accomplished, says Sheri R. Colberg, PhD, professor emerita of exercise science at Old Dominion University in Norfolk, Virginia.

RELATED: 6 Great Exercises for People With Diabetes

The most important message is that people have to do whatever they can with their lifestyle to improve their insulin sensitivity, says Dr. Colberg, who wasnt involved in the study. Insulin sensitivity refers to how efficiently the body can use the hormone to convert sugars into energy.

Dietary restriction can help with this and insulin resistance decreases even before significant weight loss but weight regain is very common, Colberg adds. Both a low-carb diet and consistent workouts can help people with diabetes lose weight and lower blood sugar, she says.

But many people who rely on diet alone to maintain weight loss regain many of the pounds they lose, Colberg says. Exercisers, on the other hand, can keep weight off when they continue to be active.

Physical activity is likely the most important way to keep muscles insulin sensitive and to avoid excess carbs being converted into fat and stored in the liver and pancreas, Colberg says.

RELATED: 7 Exercise Motivation Tips for People With Type 2 Diabetes

More:
Study Sheds Light on How Fat Loss Can Put Type 2 Diabetes in Remission - Everyday Health

Photo Credit Getty Images

The month of January is regarded as National Thyroid Awareness Month that aims to bring to public attention the need to take good care of the important tiny gland in the neck known as Thyroid. The entire month is used to make people aware of the diseases associated with this gland as it is very important for the timely diagnosis of different health ailments.

The World Health Organization estimates about 750 million people around the world suffer from a thyroid malfunction. Women are up to eight times more likely to experience disorders than men.

Relevance of Awareness

According to the Indian Journal of Endocrinology and Metabolism an estimated 42 million people in India are suffering from thyroid diseases. Out of this, over 20 per cent women in India live with an undiagnosed thyroid problem and do not even realize that it is the cause of various health issues including infertility, health experts have noted. Moreover, the global prevalence of thyroid disorders are also on the rise day by day. Hence it becomes essential to become aware of ones thyroid and its relationship to health and how best to take care of it.

Thyroid gland

The thyroid is a small, butterfly-shaped gland located in the base of the neck just below the Adam's apple. Although relatively small, the thyroid gland influences the function of many of the bodys most important organs, including the heart, brain, liver, kidneys, and skin. Ensuring that the thyroid gland is healthy and functioning properly is important to the body's overall well-being.

Role of the Thyroid

Thyroid gland is the most crucial determiner of a persons metabolic rate and energy. The thyroid as part of the endocrine system, keeps the metabolism under control through the action of thyroid hormones - which it makes by extracting iodine from the blood and incorporating it into its hormones. Thyroid cells are unique in that they are highly specialized to absorb and use iodine. Every other cell depends on the thyroid to manage its metabolism.

The main role of the thyroid is to produce and release the hormones that your body uses to determine how much energy to use, says Dr Hussein Saadi, chief of the Medical Subspecialties Institute at Cleveland Clinic Abu Dhabi. The hypothalamus of the brain produces the thyroid-releasing hormone (TRH), which stimulates the pituitary gland to produce thyroid-stimulating hormone (TSH). That prompts the thyroid to produce and secrete thyroxine (T4) and triiodothyronine (T3) hormones into the bloodstream.

Thyroid Hormones and Functions

The two main hormones the thyroid produces and releases are T3 (tri-iodothyronine) and T4 (thyroxine). A thyroid that is functioning normally produces approximately 80% T4 and about 20% T3, though T3 is the stronger of the pair. To a lesser extent, the thyroid also produces calcitonin, which helps control blood calcium levels

These hormones are crucial for the optimal functioning of the brain, kidneys as well as liver alongside playing a vital role in the growth and development of the body. They also help in breathing, regulating the cholesterol level, body weight, improving muscle strength and maintaining heart rate.

Thyroid Problems

There are many diseases and disorders associated with the thyroid. Overactivity or underactivity of the gland may lead to a hormonal imbalance in the body that would be evident through various symptoms. They can develop at any age and can result from a variety of causesinjury, disease, or dietary deficiency, for instance. But in most cases, it can be briefly summarised as:

Common Thyroid Disorders

Hyperthyroidism: Hyperthyroidism is caused by too much thyroid hormone due to an over active thyroid. People with hyperthyroidism are often sensitive to heat, hyperactive, and eat excessively. The symptoms include anxiety, shaking, weight loss, irritability, restlessness, nervousness, trouble in sleeping etc. Goiter is sometimes a side effect of hyperthyroidism; due to an over-stimulated thyroid and inflamed tissues. Hyperthyroidism is often diagnosed by checking the levels of TSH and T4 - an increased level of T4 and a low level of TSH can usually confirm the condition.

Hypothyroidism: Hypothyroidism is a common condition characterized by too little thyroid hormone due to the inactivity of the gland. This may lead to symptoms like depression, memory problems, dry skin, constipation, dry skin, weight gain, slow heart rate etc. In infants, the condition is known as cretinism which has very serious side effects, including abnormal bone formation and mental retardation. If hypothyroidism is detected as an adult, one may experience sensitivity to cold, little appetite, and overall sluggishness. Low levels of thyroid hormone can interfere with ovulation, which impairs fertility, experts point out. Hypothyroidism often goes unnoticed, sometimes for years, before being diagnosed. A high TSH level and low T4 mostly confirms the condition.

Goiter: A goiter is a bulge in the neck- a toxic goiter is associated with hyperthyroidism, and a non-toxic goiter, also known as a simple or endemic goiter, is caused by iodine deficiency.

Solitary thyroid nodules:Solitary nodules, or lumps, in the thyroid are actually quite commonin fact, its estimated that more than half the population will have a nodule in their thyroid. The great majority of nodules are benign. Usually, a fine needle aspiration biopsy (FNA) will determine if the nodule is cancerous.

Thyroid cancer: Thyroid cancer is fairly common, though long-term survival rates are excellent. Occasionally, symptoms such as hoarseness, neck pain, and enlarged lymph nodes occur in people with thyroid cancer. Thyroid cancer can affect anyone at any age, though women and people over thirty are most likely to develop the condition.

Thyroiditis: This is an inflammation of the thyroid that may be associated with abnormal thyroid function, particularly hyperthyroidism. Inflammation can cause the thyroids cells to die, making the thyroid unable to produce enough hormones to maintain the body's normal metabolism. There are several types of thyroiditis, and the treatment is specific to each.

Hashimotos disease: This condition of thyroiditis occurs when the bodys own immune cells attack thethyroid gland by mistakerendering it unable to producehormones anymore. Also known as Chronic Lymphocytic Thyroiditis, itcan affect anyone regardless of age though its is most common in middle aged women. The condition is characterised by fatigue. dry skin, thinning of hair, constipation among others.

Measures for a healthy thyroid

(The author is Director- TGL, Chairperson CSA, Sr Dir, FWO, Editor - The International Journal)

See the original post:
Know your Thyroid Gland and How to take care of it - Mathrubhumi English

Researchers at the University of Maryland School of Medicine (UMSOM) developed a new nanoparticle drug formulation that targets a specific receptor on cancer cells and appears to be more effective than a standard nanoparticle therapy currently on the market to treat metastatic breast cancer, according to a study published today in the journalScience Advances. The new DART nanoparticles bypass healthy cells and tissues and bind to tumor cells, dispersing evenly throughout the tumor while releasing the chemotherapy drug paclitaxel.

The marketed drug Abraxane, a nanoformulation containing paclitaxel that is currently used to treat women with aggressive breast cancer, is an effective agent, but it was not designed to selectively deliver paclitaxel to only the cancerous cells within the body, said study corresponding co-authorJeffrey Winkles, PhD, a Professor of Surgery at UMSOM. Our DART nanoparticle specifically targets the Fn14 receptor found abundantly on breast cancer cells; it uses this receptor to gain entry through the plasma membrane and deliver the drug to destroy the cancer. Dr. Winkles group discoveredthe Fn14 receptorand described its potential as a target for new therapeutics more than a decade ago.

For this study, UMSOM researchers engineered and tested a new therapeutic nanoparticle platform to deliver the drug paclitaxel to treattriple-negative breast cancer. About one in five women with breast cancer have this type of aggressive tumor, which is particularly difficult to treat; these cancers lack receptors commonly expressed by most breast cancer cells, like hormone receptors, for which effective drugs have been designed. But many triple-negative breast cancers express high levels of Fn14; indeed, most solid tumor types, including lung, prostate and colorectal cancer, overexpress this cell surface receptor.

To accomplish this, the research team attached a monoclonal antibody called ITEM 4 to the surface of the nanoparticle because it specifically binds to Fn14, providing a key to unlock entry into the cancer cell. The surface of the nanoparticles was also coated with polyethylene glycol to keep them circulating through the bloodstream and lymph system until they reached the tumor and to prevent them from being quickly flushed out of the body.

Many drug delivery carriers exhibit nonspecific binding to healthy cells and tissues in addition to the diseased cells they are targeting, which often leads to unintended side effects or toxicities, said study corresponding co-authorAnthony Kim, PhD, Associate Professor of Neurosurgery and Pharmacology at UMSOM. This DART nanoparticle platform has unique capabilities to improve therapeutic delivery to difficult-to-treat locations within the body, while also allowing us to potentially increase the maximum tolerated dose of the encapsulated drug without increasing side effects to patients.

The researchers filled their optimized DART nanoparticle formulation with paclitaxel and tested it against Abraxane (the marketed nanoparticle which also contains paclitaxel) in animals with triple-negative breast cancer tumors. In one set of experiments, the nanoparticles were delivered to mice harboring breast tumors grown above the natural breast region. They found the DART formulation led to a significantly increased median overall survival (68 days) compared to Abraxane treatment (45 days). They also saw a clear benefit to using the DART nanoparticles when they compared the treatments again in animals that harbored breast tumors implanted in the brain (akin to a metastatic brain tumor).

This is a compelling finding and significant step forward in the use of nanoparticles to treat cancer, saidUMSOM Dean E. Albert Reece, MD, PhD, MBA, University Executive Vice President for Medical Affairs and the John Z. and Akiko K. Bowers Distinguished Professor. It fits squarely with our School of Medicines mission to advance the field of potentially lifesaving therapies for patients with the most difficult to treat cancers.

The UMSOM researchers are members of the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center. A former Ph.D. student, Jimena Dancy, PhD, and a former Postdoctoral Fellow, Aniket Wadajkar, PhD, are listed as co-first authors on the publication. Researchers from the Translational Genomics Research Institute in Phoenix, Arizona and the Mayo Clinic Arizona in Scottsdale also contributed to the work.

This study was primarily funded by the National Institutes of Health.

Future research includes testing the DART therapy in other cancer types, including an aggressive form of brain cancer calledglioblastomaand developing a similar version of the nanoparticle designed to work specifically in humans. This would involve using a humanized antibody on the surface of the nanoparticle and scaling up the formulation. The researchers recently received a grant from the TEDCOMaryland Innovation InitiativeCommercialization Program to move forward with efforts to adapt their nanoparticle system and eventually test the treatment in cancer patients.

Reference: Dacy, et al. (2020) Decreased nonspecific adhesivity, receptor-targeted therapeutic nanoparticles for primary and metastatic breast cancer. Science Advances DOI:10.1126/sciadv.aax3931

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Read the rest here:
Team Develops New Nanoparticle Drug To Treat Aggressive Breast Cancer - Technology Networks

In a few months, a bunch of testosterone-loving men will host a convention in Florida aimed at teaching women how to be great great wives, great mothers and great sexual objects. Its called The 22 Convention: Make Women Great Again, and we cant quite wrap our minds around it. At first, second and third glances, the website almost seems like satire. We couldnt tell if it was real, with descriptors like the mansplaining event of the century. But this is a bona fide anti-feminist organization charging $2,000 per ticket.

Its with some reluctance that were even responding to this mind-boggling and pathetic news. To these guys, any press is good press, and they revel in any backlash, threats or uproar created by their hyper-masculinity and incredibly toxic views on women. They are bullies, and we should just ignore them. But taking that high road has become more and more exhausting for women, as its stretching longer and higher. And were tired.

Were tired of men legislating, governing, raping, abusing, judging and body shaming us. Were tired of men telling us to smile. Were tired of men trying to upend our reproductive rights. Were tired of men telling us to sit down and be quiet. Were tired of men.

Not all men, of course. But the good guys rarely make headlines. And they definitely dont host viral conferences on how to make women great again. The good guys dont get enough credit for supporting us, respecting us and lifting us up. But, unfortunately, talking about the good guys isnt enough right now.

So that you get an idea of how awfully ludicrous this event is, know that one of its speakers is alt-right, proud white nationalist Stefan Molyneaux. Perhaps the most damaging part of this event isnt even the male hosts themselves, but the women who believe that their entire sense of self should be manufactured, manipulated or otherwise established by someone else.

This very first 22 Convention is actually a spinoff of the long-running 21 Convention, which is a celebratory event for men and fathers. That figures. We can list all the reasons why this incredibly detached-from-reality thought process is detrimental to the success, wellness and happiness of womankind, but wed like to think most people know what that list would look like. Instead, we broke down the three points these men think will make women great again.

Lets begin with what weve dubbed the great sexual objects part of the conference. One part of the 22 Convention goes like this, according to its website: Men admire healthy, fit women. They are after all sizing you up for reproduction, and your decisions will be passed on to your children through the choices you make via epigenetics. And the descriptions go on to bash the body positivity movement, and explain that overweight women are not beautiful, with one source linking to a Wikipedia page.

Deep breath in. OK.

Lets remind these men that a healthy lifestyle is not synonymous with any one body type or shapebecause were women and are used to defending and justifying our own bodies, sadly.

Weight-wise, a healthy adult woman because these men seem to thinkhealthy and fitare simply based off of weight will have a body mass index ranging from 18.5 to 24.9, according to the Mayo Clinic. This writer can tell you firsthand that her BMI is within this criteria, and she hasnt been comfortable in a bikini since her early 20s. After all, many of us have birthed children, wreaking havoc on our bodies, causing stretch marks, loose skin and less-than-perky breasts which, by the way, the 22 Convention men should be prepared for because they, according to their own website, want more women to be mothers. We cant wait until they announce the 23 Convention, tackling how to better the postpartum womans body, with special sessions on techniques to hide your stretch marks from your husbands so theyll still find your body desirable. But we digress.

Wed be remiss if we didnt mention that, according to the websites own source link, a Wikipedia page for Obesity in the United States, 19 million more men are overweight or obese than women. I guess these guys didnt see that part. Whats the old Bible verse? "Why do you look at the speck of sawdust in your brother's eye and pay no attention to the plank in your own eye? Even as an atheist, this writer can still appreciate the sentiment. Pay attention, 22 Convention bros. Better put in a few extra laps.

Now, lets address that epigenetics part. According to futuremedicine.com: It has been identified that several lifestyle factors such as diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants, psychological stress and working on night shifts might modify epigenetic patterns.

We thought wed break down some of those lifestyle factors by gender.

According to webmd.com, 15% more men are obese than women. According to drugabuse.com, 3.1% more men use tobacco than women. According to the Centers for Disease Control and Prevention, men are more likely than women to drink excessively. And, just a side note, according to the CDC, Excessive alcohol use can interfere with testicular function and male hormone production resulting in impotence [and] infertility. Tell us more about epigenetics, guys.

Moving on to the great wives portion of the conference. The 22 Conventions website says this: ...both positive masculinity and femininity have been under relentless attack for decades. Both have taken catastrophic social, cultural, personal, and philosophic damage for tens of millions of people. The result is a depolarized mess where men act like women, women act like men, everyones confused, and nothing 'works' anymore. There is no source linked for this tens of millions of people claim. The website continues with a promise to help women find awesome men, that women belong in the kitchen and the bedroom, becoming the ultimate wife material and the truth about submission and dominance.

OK. Another deep breath in.

According to Psychology Today, women initiate nearly 70% of all divorces. And, according to Business Insider: Compared to being single, marriage is a bum deal for many [women]. Accordingly, married women are less happy than single women and less happy than their husbands, they are less eager than men to marry, they're more likely to file for divorce and, when they do, they are happier as divorcees than they were when married (the opposite is true for men) and they are more likely than men to prefer never to remarry. The writer, who has a doctorate in sociology, refers to this as a "paradox of declining female happiness." If women are marrying these convention bros, its really no wonder were filing for divorce at such high rates.

And while we could unpack the entire depolarized mess where men act like women, women act like men part of the conventions description, well just say this: Psychology Todayalso reported results of women rating mens attractiveness on their masculinity. These results are interesting because they show that women are not performing a binary trade-off, preferring more macho men in one situation and less macho men in another. Instead, a womans personal circumstances affect her preferences to different degrees depending on the men she encounters. In other words, the macho man agenda these MWGA guys promote as what all women want is bullshit.

Onto the great mothers segment of this shit show. The conventions website says: For decades, feminism has derided women who want to prioritize motherhood and family. Shamed them, mocked them, ridiculed them as servants of some mysterious patriarchy boogeyman. These clever manipulations were designed to weed you out of the gene pool and forever prevent you from embracing the sacred responsibility, honor, and adventure of motherhood. Our speakers will teach you the skills to get wifed up, knocked up, and have as many babies as your heart desires with the time and fertility you have left, and how to bounce back to amazing health and wellness without extreme diets or stress. The clock is ticking and your babies are soon to be kicking!

Lets just pour ourselves a stiff drink at this point.

First, and again, there are no sources linked to these statements of women suffering ridicule for decades for not wanting kids. Its true that a lot of women do not want to have children, but that should play no part in a mans opinions on a woman, unless she is his partner and he wants kids. Its that simple. Also, these guys talk a lot about preserving the gene pool. Sounds familiar.

Regarding the idiotic idea that motherhood is a responsibility for women, let us remind men the gender that cannot become pregnant that not only do women not have to have children, not all women CAN have children. I guess theyll address that in Convention 24 where well all learn how wives can pretend to have children so their husbands will still love them.

As far as the ticking clock of our fertility, more women are having children in their 40s, according to The Atlantic: Birth rates also declined last year for women under 40 but rose for women older than 40. And, according to The New York Times, immediately after a husband and wifes first child, the pay gap between spouses doubles ... entirely driven by a drop in the mothers pay. So, convention bros, were going to need you to take over most, if not all, finances if were to have as many babies as [our] heart desires.

We can say this: Women who truly believe that they are inferior to men, that they dont take up as much space as men, that they want to live a life of obedience to men and have $2K to cough up to hear from men on how to be attractive and wanted by men, then go to this event. For anyone else who identifies as a woman, who understands their worth, enjoys all aspects of womanhood and likes men who can find a clitoris, lets just keep being great.

Diamond Rodrigue is layout editor and writes about music and culture for the Dallas Observer.

Read the original here:
Florida Men Who Have Never Touched a Woman Free of Charge Want to Make Women Great Again - Dallas Observer

Global Male Hypogonadism Market: Snapshot

Hypogonadism in males refers to a condition in the male body where the testes show a significantly reduced level of functioning than normal. The overall result of male hypogonadism is a reduction in the rate of biosynthesis of male sex hormones. This state is more commonly known as interrupted stage 1 puberty. Hypoandrogenism, or the low androgen or testosterone level in a male can vary in severity from person to person. It is often the cause of partial or complete infertility. There are multiple forms of male hypogonadism and even more ways to classify them. Most endocrinologists commonly classify male hypogonadism on the basis of the level of defectiveness of the male reproductive system.

In many cases, doctors also measure the level of gonadotropins to classify a patient between primary and secondary male hypogonadism. Primary male hypogonadism refers to the cause of the condition being due to defective gonads. There are different types of primary male hypogonadism, including Turner syndrome and Klinefelter syndrome. Secondary male hypogonadism is caused by defects in pituitary or hypothalamic glands. They include Kallmann syndrome and hypopituitarism.

Get Sample Copy of the Report @https://www.tmrresearch.com/sample/sample?flag=B&rep_id=1127

Global Male Hypogonadism Market: Overview

Male Hypogonadism refers to a clinical condition, wherein the testes fail to produce enough testosterone leading to delayed puberty or incomplete development. The condition is related to impaired development of muscle mass, development of breast tissues, impaired body hair growth, and lack of deepening of the voice.

The male Hypogonadism market can be segmented by therapy, type, drug delivery, and geography.

The report presents an in-depth analysis of the global male hypogonadism market with current trends and future estimates to explain the imminent investment pockets. The quantitative analysis of the market for the forecast period from 2017 to 2025 will enable stakeholders to capitalize on the prevailing growth opportunities.

Global Male Hypogonadism Market: Trends and Opportunities

The top driver of the male hypogonadism market includes rising prevalence of testosterone deficiency among men, increasing infertility rates, and increasing awareness among individuals about hypogonadism treatment due to awareness drives organized by several governments across the world. Moreover, high risk of hypogonadism among the geriatric population with obesity and diabetes, and increasing prevalence of chronic disorders among the geriatrics are further expected to boost the markets growth.

However, factors such as high side effects of testosterone products are challenging the growth of testosterone replacement therapy market. Top players in the market are focused on research and development to introduce newer products with fewer or negligible side effects and improved results. For example, LPCN 1111, a product which is under development from Lipocine Inc., is a newer testosterone prodrug that utilizes Lipral technology for enhanced systemic absorption and for enhanced solubility of testosterone. Nevertheless, technological advancements are anticipated to extend new opportunities to the markets growth.

Global Male Hypogonadism Market: Regional Overview

The global male Hypogonadism market can be analyzed with respect to the regional segments of North America, Asia Pacific, Europe, Latin America, and the Middle East and Africa. North America held the majority share of the global market in the recent past and is expected to retain its dominant position in the near future. This is mainly due to the rise in the number of individuals suffering from primary and secondary conditions of hypogonadism, and rising awareness among individuals about treatment options for the condition. Moreover, the presence of ultra-modern healthcare infrastructure and increasing popularity of technologically advanced products are expected to offer new opportunities for top players in this market. The region is closely followed by Europe.

Asia Pacific is expected to offer lucrative opportunities to this market due to the modernization of the healthcare infrastructure in the emerging economies of India and China and the increasing awareness about the treatment for the condition. In Asia Pacific, the increasing prevalence of hypogonadism and infertility rates along with the rising geriatric population base with diabetes and obesity are propelling the growth of this market. China, Taiwan, and Malaysia are some of the countries that display the highest rate of male hypogonadism.

Major Companies Mentioned in Report

Some of the key players in the male Hypogonadism market include AbbVie Inc., Astrazeneca plc, Eli Lilly and Company Ltd., Merck & Co. Inc., SA, Finox Biotech, Laboratories Genevrier, Teva Pharmaceutical Industries Ltd., Allergan plc, Bayer AG, Endo International plc, IBSA Institut Biochimque, and Ferring.

Key players are focused on product approval for growth considerations and to cater to the changing demand of the industry. The introduction of innovative and technologically advanced products is also the focus of key players to increase their market share and for serving patients in a better manner.

Read Comprehensive Overview of Report @https://www.tmrresearch.com/male-hypogonadism-market

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TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in todays supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

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Male Hypogonadism Market Analytical Overview and Growth Opportunities by 2025 - Fusion Science Academy

Another winter of studying wolves at Isle Royale National Park is getting underway/NPS file

Editor's note: The following story was written by Allison Mills at Michigan Technological University.

On October 20, a ranger on his final hike for the season in Isle Royale National Park came across a dead wolf lying in the trail. An era ends and new packs may form.

Over the past year, the National Park Service and regional partners brought more than adozen new wolves to Isle Royaleas only two island-born wolves remained. This past fall, the park documented two wolf deaths both caused by injuries inflicted by another wolf or group of wolves. One wolf was the male of the native pair.

To help document the shifting social hierarchies of the island, the 62nd Winter Study is underway in the Isle Royale National Park led by Michigan Technological University.

Rarely do we find dead wolves unless they are radiocollared, said Rolf Peterson, a research professor in theCollege of Forest Resources and Environmental Scienceat Michigan Tech who co-leads the annual Isle Royale Winter Study. He helped park staff recover the carcass of the old male wolf, who was not radiocollared.

His death, and finding the intact body so soon after, presents an extremely rare chance to study his genetics, Peterson said. Finally, his heritage will be clear and we will have a better understanding of the Isle Royale wolf story. Also, it remains to be seen what will happen with new packs forming.

The male wolf was 11 years old and his mate, who was both his sister and daughter, is now nine years old. Based on necropsy results from the US Geological Surveys National Wildlife Health Center, the cause of death was wolf-inflicted wounds. The pair had been the last remaining wolves on the island until the National Park Service introduced new wolves from Ontario, Minnesota and Michigan; these deaths and wolf-on-wolf aggression are not uncommon as wolves defend and establish their territories and social hierarchy. There are now 15 wolves on the island seven females and eight males. The new wolves wear radio collars, so researchers track their movement as they explore the island.

The research from Isle Royale gives us a glimpse into the predator-prey dynamics and its impact on the islands ecology:isleroyalewolf.org

With her mate gone, the female wolf may seek out a new partner, whose new offspring is unlikely to fall prey to the inbred genetics that crashed the original population. In partnership with the National Parks Service, Kristin Brzeski, assistant professor of wildlife ecology and genetics at Michigan Tech, will be studying the old male wolfs genome. With an esteemed heritage his grandmother was known as the Cinderella Wolf and his great grandfather The Old Grey Guy, two important wolves within theIsle Royale family tree the males genes carry the story of genetic rescue and severe inbreeding, phenomena that are hard to study in the wild. Phil Hedrick from Arizona State University, a longtime collaborator on the Isle Royale project, will also be contributing to the research. A deeper understanding of the old packs downfall can help inform wildlife management and conservation decisions on the island and around the world.

The wolves of Isle Royale have been showing us for some time now how the life of an individual animal can affect an entire ecosystem, said John Vucetich, professor of ecology and another Winter Study co-lead. The Old Grey Guy, who came across an ice bridge and introduced new genes into the population, and Cinderella, a notable alpha who survived a pack coup, are important examples. And the recovery of this carcass from the last known male wolf of the previous population may well prove to be another important example."

If the female does not choose a new mate, a power struggle may ensue as alpha contenders emerge and new packs form. The radio-collar movement patterns reveal wolves sharing bed sites, meals and hunting grounds as well as watching one another from a distance. Or rather listening: Wolves communicate territorial boundaries and pack identity through howling.

The wolves are good at detecting vacancies, Peterson said. Anything could happen at this point. This years drama is just beginning.

The next Winter Study report is expected to come out late in winter 2020 with an update on the wolves, moose population growth and health, small mammal populations and browsing impact on vegetation.

Link:
Another Winter Of Wolf Study Begins At Isle Royale National Park - National Parks Traveler

The main factor that influences a person's height is their genetic makeup. However, many other factors can influence height during development, including nutrition, hormones, activity levels, and medical conditions.

Scientists believe that genetic makeup, or DNA, is responsible for about 80% of a person's height. This means, for instance, that tall people tend to have children who also grow up to be tall.

People usually grow until they reach 18 years of age. Before then, a range of environmental factors can affect how tall they become.

This article covers the factors that affect a person's height, some ways people can increase height during development, and whether or not adults can increase their height.

Babies and children grow continuously. This is due to changes in the growth plates in the long bones of their arms and legs.

As the growth plates make new bone, the long bones get longer, and the child gets taller.

People grow the fastest in the first 9 months of life, before being born. After birth, this slows down.

Once a child is 8 years old, they will grow at an average of 2.16 inches (in), or 5.5 centimeters (cm), per year.

That said, teenagers will have a "growth spurt" around the time of puberty. After this, the growth plates stop making new bone, and the person will stop growing. The hands and feet stop growing first, then the arms and legs. The last area to stop growing is the spine.

Due to typical aging processes, people begin to lose height gradually as they get older.

The following factors can affect how tall a person will become:

DNA is the main factor determining a person's height.

Scientists have identified more than 700 different genes that determine height. Some of these genes affect the growth plates, and others affect the production of growth hormones.

Normal height ranges are different for people from different ethnic backgrounds. Again, this is determined by their DNA.

Some genetic conditions can also affect a person's adult height, including Down syndrome and Marfan syndrome.

The body produces hormones that instruct the growth plates to make new bone. These include:

Males tend to be taller than females. Males may also continue growing for longer than females. On average, an adult male is 5.5 in (14 cm) taller than an adult female.

According to the Centers for Disease Control and Prevention (CDC), in the United States, the average male is 69 in (175.2 cm) tall, and the average female is 63.6 in (161.5 cm) tall.

Learn about what age girls stop growing and what age boys stop growing here.

People cannot control most of the factors that influence their height. This is because they are determined by DNA, which they cannot change.

However, some factors can increase or reduce growth during childhood and puberty. Growing children and teenagers can take some steps to maximize their adult height. These include:

Nutrition plays a very important role in growth. Children without good nutrition may not be as tall as children with adequate nutrition.

Nutritionists recommend that children and young people eat a varied, balanced diet with plenty of fruit and vegetables. This will ensure that they get all the vitamins and minerals they need to thrive.

Protein and calcium are particularly important for bone health and growth. Some protein-rich foods include:

Some calcium-rich foods include:

Ensuring good nutrition during pregnancy is also important for the bone health and growth of the fetus.

The World Health Organization (WHO) recommend that pregnant women consume a variety of foods, including "green and orange vegetables, meat, fish, beans, nuts, pasteurized dairy products, and fruit."

Sleep promotes growth and development in children and teenagers. During deep sleep, the body releases the hormones it needs to grow. Getting enough sleep may therefore allow optimal growth.

Regular exercise is also important for normal physical development. Playing outside or taking part in sports, for example, can make bones healthier, denser, and stronger.

Once a person has been through puberty, the growth plates stop making new bone. They fuse together, and the person stops growing. This means that when a person reaches 18 years of age, they are not able to increase their height.

Practicing good posture and keeping the back and core muscles strong can allow a person to stand straighter and appear taller.

Learn more about growing factors that affect height as an adult here.

Height is largely determined by DNA. However, environmental factors such as nutrition and exercise can affect growth during development.

As children get older, they need good nutrition and plenty of exercise to help their bodies make the hormones they need to grow. Teenagers will experience a growth spurt during puberty. After that, their bones will stop growing, and they will not get any taller.

Good nutrition during pregnancy is also important for the future bone health and growth of the baby.

Read more here:
How to increase height: Factors that influence growth - Medical News Today

For the first time in almost a decade, Suffolk County Police have released new evidence in connection with the Gilgo Beach serial killer case.

During a press conference on Thursday, Jan. 16, policereleased an image of a black leather belt with two initials that they believed could belong to the killer because it had not been touched by any of the victims.

The belt is imprinted with the letters "WH" or "HW" depending on the way the belt is turned.

Suffolk Police Commissioner Geraldine Hart saidshe hoped the release of the evidence could help identify a suspect.

"We remain steadfast in our commitment to delivering justice to the victims," Hart said.

The serial killer case was opened during the search for Shannan Gilbert, 24, a Jersey City woman who solicited for sex on Craigslist, was reported missing in May 2010.

During the search for Gilbert, a K-9 officer and his dog uncovered the remains of another missing woman who worked in the sex business in a clump of weeds along Ocean Parkway near Jones Beach in December of 2010.

Where the bodies were located near Gilgo Beach. Suffolk County Police

What followed was a mass search of the area by police that uncovered the remains of nine additional bodies, including seven women, a baby, and an adult male.

Police have only been able to identify half of the bodies, with four sets of remains including the infant and male, still unidentified.

No arrests have ever been made in connection with any of the bodies found.

Photos of some of the women found whose bodies were found at Gilgo Beach. Suffolk County Police

Police have said in the past they don't believe Gilbert's murder is connected to the serial killer due evidence they have not released.

Hart declined to say why the department is releasing the belt at this time, or what size it was.

During the conference, the department also announced a new website http://www.gilgonews.com will be used as a way for police and the public to exchange information on the investigation and as a way for the public to send in tips anonymously.

"We are asking the public to consider the information on the website and whether they have information that can bring the case forward," said Hart.

The department is also still waiting for the results of a new genetic test being used in the case in hopes of finding the killer or identifying the other bodies.

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Original post:
Police Release Image Of Belt That May Belong To Serial Killer In Gilgo Beach Case - Daily Voice

Do you want to know the gender? the doctor asked me, after delivering the news of our healthy embryos.

What?

Do you want to know? Many people want to select.

I just want the healthiest embryos, I answered reflexively. The ones most likely to survive.

My doctor had just delivered the genetic testing results of our 13 embryos, created in the lab through in vitro fertilization: three healthy embryos, two girls and one boy. After multiple miscarriages, I wanted a baby who would live. I didnt care if it was a boy or a girl, with blue eyes or brown, or curly or straight hair. I wanted a baby who was breathing.

I am an accidental fertility expert. Fertility was not something I thought much about, until confronted with years of trying to conceive and the devastating pain of my first miscarriage, followed by six additional miscarriages and almost a dozen failed IVF attempts.

Over the course of nine years, I saw 10 doctors in six countries, and turned to state-of-the-art medical practices as well as traditional approaches to overcome infertility. I tried Clomid to encourage my body to ovulate, then intrauterine insemination (IUI) to assist with fertilization, followed by in vitro fertilization (IVF) to actually force it. When that failed, my husband and I turned to preimplantation genetic testing (PGS) in hopes of finding a good embryo. And when my body couldnt carry our sole healthy embryo, we finally embraced the idea of a gestational surrogate.

During the course of our years-long fertility journey, my husband and I discovered that we were part of a growing demographic of the infertile in America. Luckily for us, fertility technology is largely keeping pace, enabling the previously infertile to achieve their dreams through new approaches previously reserved for the province of science fiction. The technology is a boon its the reason we have our own children.

But it was also an exhausting process. There was the emotional trauma, physical toll and financial burdens of infertility, and, on top of that, the prospect of forging into legally complicated and morally untested territory.

When my husband and I entered the world of advanced reproductive technology, we had no thoughts of social engineering; we just wanted to have a baby. Yet society abounded with criticisms of the techniques we were employing: Gender selection will lead to people asking for blond-haired, blue-eyed babies. Women will begin using surrogates to avoid getting fat.

These are valid concerns and must be thought about carefully in crafting safe and ethical guidelines. But these slippery-slope arguments fail to convince me. Having subjected myself to uncountable injections, ultrasounds and anesthetized egg retrievals, I simply dont accept that women would opt for daily needles to create designer babies, or would choose not to carry their own baby to escape putting on weight.

People turn to these technologies because they need them to have a healthy child.

Louise Brown, the first IVF baby, was born in 1978. In the four decades since her birth, new and more powerful techniques have emerged, pushing the boundaries of human reproduction outward. But legal and ethical discussions around fertility technology have stalled, resulting in virtually no national regulation. Paired with a ban on federal research, this means aspiring parents must often assess not only the efficacy, but also the morality, of potential procedures themselves.

(Credit: Jay Smith/Discover)

For example, before considering the selection of a boy or a girl, we had to confront the question of whether we even wanted the power to choose a decision that made me uneasy. If I had gotten pregnant naturally, I wouldnt get to pick the gender. Wouldnt this be cheating?

Considering what had seemed like the technical question of whether to transfer two or three of the genetically tested, healthy embryos that cycle into a surrogate rather than me suddenly became difficult. It was more than just a science project we were talking about potentially getting another woman pregnant with two or three babies that would become our actual children, to have and raise forever. But if we transferred too few, we might end up with none. Again.

I agonized all night.Could I handle triplets? Was that fair to Catherine, our surrogate?

I neednt have worried. By the time we got to the clinic the morning after receiving the news, the male embryo was no longer viable, and the two females were loaded in the catheter to be transferred. Wed avoided an uncomfortable choice for the time.

But these questions are just the tip of the iceberg when it comes to fertility technology.

A few of the dilemmas hopeful parents must wrestle with: What makes a parent a parent? The person who provides the genetic material? The woman who carries the baby? The individuals who commissioned the birth? (In our case, we carefully chose a jurisdiction in which we were confident that, as the genetic parents, we would be recognized as the legal parents. But thats not true everywhere.)

Is it morally acceptable to select an embryo for certain traits, like gender? (While we opted not to, people do every day).To create a baby who is a perfect genetic match to save the life of another through bone marrow or organ donation? (If we have the technology, some argue, why not?)

These are hard questions, with no easy answers. Yet future aspiring parents will likely have to deal with still harder choices, as even more disruptive breakthroughs are on the horizon.

Mitochondrial replacement therapy, in which the nucleus of the mothers egg is removed and injected into a healthy donor egg to avoid certain genetic diseases, was used to create a so-called three-parent baby for the first time in Ukraine in 2017; more are likely to follow. And, in 2018, a Chinese researcher used the gene editing technology CRISPR to edit the genomes of twin girls when they were still embryos to protect them from HIV a move that was widely condemned as premature. Both techniques irrevocably alter the germ line, meaning that any changes are passed down to future generations.

With the rapid evolution of technology, policymakers can no longer ignore the reality that human reproduction is quickly changing. Legislators must step up to the task of delineating clear rules for parents, doctors and scientists. This includes guidance on parental rights, how many embryos may be transferred during IVF, how many babies may come from a single donor, and, perhaps most importantly, a framework for evaluating the safety, efficacy and morality of emerging techniques, such as gene editing.In the absence of guideposts, doctors and patients alike will face literally life-changing decisions about how far they are willing to go to create a much-desired child.

While the medical community debates these difficult issues, science will, in all likelihood, continue to forge ahead. The very real ethical dilemmas involved in allowing trace amounts of another womans DNA to be incorporated into an embryo or genes to be edited before birth notwithstanding, I suspect that new parents have a different perspective on the issue. They are, in all likelihood, simply marveling at their 21st-century miracle babies, and the many paths that can lead them to having the family of their dreams.

Elizabeth Katkin is the author of Conceivability: What I Learned Exploring the Frontiers of Fertility

This story is part of "The Future of Fertility" a new series in Discover exploring the frontiers of reproduction.

Read more:

Can Humans Have Babies in Space?

George Church Wants to Make Genetic Matchmaking a Reality

Human Gene Editing is Controversial. Shoukhrat Mitalipov Isn't Deterred

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My Long and Arduous Journey Across the Frontiers of Fertility Technology - Discover Magazine

This article contains spoilers forRuins of Ravencroft: Sabretooth #1.

It seems the classicX-Men villain Mr. Sinister is an expert on aspects of magic as well as mutation. Born Nathaniel Essex, Sinister was a contemporary of Charles Darwin who theorized that evolution didn't always happen incrementally. He was shunned for his views, not to mention his unorthodox experiments, which horrified the British Royal Society.

An unfortunate encounter with Apocalypse left Nathaniel Essex transformed him into an ageless and immortal being. He traveled the globe, fascinated by humanity's potential to develop and evolve. The X-Men comics have long hinted at the kind of unethical experiments he conducted on mutants; in fact, Sinister meddled with Charles Xavier's own bloodline, foreseeing greatness in the genetic potential of the Xaviers.

Related:Wolverine's Biggest X-MEN Reboot Mystery Has Been Solved

Ruins of Ravencroft: Sabretooth #1 by Frank Tieri, Guillermo Sanna, Angel Unzueta, and Gerardo Sandovalreveals that Sinister's earliest experiments weren't upon mutants. In the early 1900s, he recognized the potential of the newly-opened Ravencroft Institute for the Criminally Insane and moved to America in order to work there. While at Ravencroft, his focus was upon mystical beings rather than mutants; creatures like vampires and werewolves, Wendigos and hydras. Sinister experimented upon them all, dissecting them, learning everything he could about them. Some samples were deemed unwanted, and were cast into a sub-basement cavern - only to survive and almost escape in the present day.

Given all this, it's reasonable to assume that Nathaniel Essex is just as knowledgeable on matters of mysticism as he is on mutation. This revelation comes at a time when the X-Men comics are being increasingly linked to the supernatural.Excalibur has retconned the history of anti-magicviolence -from the Valais witch trials of the 15th century to French legends like theBeast ofGvaudan - was in part directed against mutants. Apocalypse, who has been a major character in these books, has been reinterpreted as a priest of Krakoa who is secretly fascinated by the mystical potential of Otherworld, a sorcerous realm linked to the British Isles. It's really not hard to see the pattern here; the current X-Men relaunch is seeing the mutant race closely tied to the supernatural.

Of course, the irony is that the X-Men themselves don't seem aware of this pattern.Apocalypse and Sinister are both keeping this secret from the rest of Krakoa's Quiet Council, most likely pushing their own dark agendas. The interesting question is whether they coincide - or whether, instead, it's only a matter of time before these two powerful and dangerous mutants find themselves operating at cross purposes.

Ruins of Ravencroft: Sabretooth #1 is on sale now in comic book stores.

More:X-Men Bringing Back Marvel's OTHER Wolverine?

Superman Finally Gets Fired From The Daily Planet

Tom Bacon is one of Screen Rant's staff writers, and he's frankly amused that his childhood is back - and this time it's cool. Tom's focus tends to be on the various superhero franchises, as well as Star Wars, Doctor Who, and Star Trek; he's also an avid comic book reader. Over the years, Tom has built a strong relationship with aspects of the various fan communities, and is a Moderator on some of Facebook's largest MCU and X-Men groups. Previously, he's written entertainment news and articles for Movie Pilot.A graduate of Edge Hill University in the United Kingdom, Tom is still strongly connected with his alma mater; in fact, in his spare time he's a voluntary chaplain there. He's heavily involved with his local church, and anyone who checks him out on Twitter will quickly learn that he's interested in British politics as well.

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The X-Men's Mr. Sinister is An Expert On Sorcery Too - Screen Rant

Sea moss (a.k.a Irish moss) is not something that you'll find in the typical American diet. But if you're of Jamaican or of Irish descent, there's a chance you've at least heard of it.

I'm first-generation Jamaican, and growing up, I was only exposed to sea moss in the form of a sugary beverage. When my family went out to a local restaurant to eat curry goat or jerk chicken, I would pick it out from the fridge in it's non-branded, homemade bottle. The sweet, creamy mixture of condensed milk, moss, vanilla, and nutmeg was a real treat after some spicy delights. But as tasty as this drink was, I knew it wasn't really healthy. So as a kid, I never thought that pure Irish moss had any beneficial properties on it's own. That is until I did some reading....

Sea moss is a type of red algae that grows on the Atlantic coastlines of North America, Europe, and the Caribbean Islands. Since the 1800s, the Irish have been harvesting it from their rocky shores to use as medicine. They even used it to get the nutrients they needed during times of famine. Jamaicans have also traditionally used sea moss to treat illness, and some have touted it to be the perfect elixir to increase male libido. Unfortunately, there's no scientific proof for the latter (sorry, guys), but there's a lot of research showing that our ancestors understood the healing potential of this plant.

While it's been embraced by Irish and Jamaican cultures, sea moss has been getting a bad rap lately. Carrageenan, a derivative of this seaweed, is a thickening agent that can be found in dairy and alt-milk products. This ingredient is said to cause inflammation and was labeled as "a possible human carcinogen by the International Agency for Research on Cancer. That's some scary news that has certainly discouraged many people from consuming this algae.

However, it's important to note that carrageenan (a chemically processed ingredient) is different than sea moss. Sea moss is a whole food that is in fact chockfull of beneficial vitamins, nutrients, and antioxidants. So while our forefathers and foremothers have used sea moss for old-time remedies they may or may not have been able to explain, here are six ways this red seaweed can improve your health along with the science to back it up.

Like chia seeds, aloe, and okra, sea moss is a mucilaginous food. As gross as this sounds, its snotty texture makes it a great healing/soothing agent for mucus membranes in the body, including in the respiratory and digestive systems. According to some animal studies, sea moss can have a prebiotic effect during digestion. This means that it can increase beneficial short-chain fatty acids in the colon, get rid of bad bacteria in the gut, and improve overall gut health and immunity.

Irish moss is full of different iodine compounds that your thyroid needs to healthily chug along. It contains DI-Iodothyronine, which is actually used to treat thyroid disorders. And it also contains high amounts of concentrated iodine, which your thyroid uses to make hormones that regulate your metabolism, digestion, mood, and more.

When it comes to capitalizing the energy stored in food, you need B vitamins. Sea moss contains a decent amount of riboflavin (B2) and folate (B9). Riboflavin is needed to break down proteins, carbs, and fats, while folate is needed to form DNA and other genetic material. When folate pairs up with B12, it also helps to create red blood cells.

During cold and flu season, sea moss smoothies could become your go-to meal. It has potassium iodide, which is great for dissolving troublesome phlegm in clogged airways. It also rich in amino acids, vitamin C, antioxidants, as well as a host of antiviral and antimicrobial agents. These nutrients can help you to fight or ward off infections.

Because of its vitamin and mineral packed gelatin-like quality, many people use sea moss masks to soothe eczema, psoriasis, dermatitis and burns. Studies have found that citrullinearginine, a compound found in Irish moss, can improve cell growth and metabolism. This compound also releases amino acids that are essential for protein and collagen synthesis. Collagen is the protein that maintains smooth skin and silky hair.

Sea moss has a bunch of magnesium and potassium, which are known mood boosters. Both minerals play a key role in brain function, and when we are low on either, we might feel crankier than usual. Some research indicates that sea moss may protect brain tissue from degeneration and Parkinson's disease.

If you are looking to get your hands on some sea moss, you can either buy it raw or in gel form. If you buy it raw, you're going to have to prepare it by washing the moss thoroughly, soaking it for about a day, then tossing it in the blender until you get the right consistency.

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Sea moss is tasteless so you can add it to a variety of dishes. In fact, it's an especially great plant-based substitute for gelatin or other thickening agents. The traditional Jamaican Irish moss drink is a popular option, but you can also put it in:

Remember, since Irish moss has little to no flavor, you can get creative when it comes to reaping the benefits of this nutritious algae. So don't be afraid to experiment. You might come up with a new, tasty recipe.

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Health Benefits of Sea Moss - Is Irish Moss Good for You? - GoodHousekeeping.com

Stafford Township, NJ Stem cell therapy is an incredible process for healing damaged tissue, so it seems remarkable that it is availablefor petsright here in Manahawkin. Stafford Veterinary Hospital, at 211 North Main St., began offering the advanced treatment in 2019, under the direction of Michael Pride, medical director at the facility.

There, stem cell therapy is most commonly applied to osteoarthritis, but can also be used in dogs suffering from hip dysplasia and ligament and cartilage injuries, as well as mobility ailments and some chronic inflammatory issues such as inflammatory bowel disease and chronic kidney disease, which is common in cats.

Stem cell therapy is actually the only thing that can help to reverse the process of arthritis, Pride said. Everything else is a Band-Aid.

This process can actually help to rebuild cartilage and really reduce inflammation without the need of using aspirin-type medications, Pride said. Its a newer technology that we can use to avoid chronic use of medications, which might actually be detrimental in the long term for the liver or kidneys.

Stem cell therapy treats the source of the problem by offering the ability to replace damaged cells with new ones, instructs the website staffordvet.com.

Stem cells are powerful healing cells in the pets body that can become other types of cells. For example, in the case of arthritis, stem cells can become new cartilage cells and have natural anti-inflammatory properties, thus reducing pain and increasing mobility.

The stem cells are your primary structural cell for all other cells in the body; they can differentiate into almost any other cell, explained Pride. Were processing it down into that primordial stem cell; were activating it, and were injecting it into where it needs to be, and it just starts taking on the characteristics of the cells around it.

Table-top machines from MediVet Biologics are the first Adipose Stem Cell therapy kits for in-clinic use, a major advancement. Stem cell therapy for animals has been commercially available since 2004. MediVet pioneered in-clinic treatment options around 2010.

Pride believes Stafford Veterinary Hospital offers the only such treatment in the immediate area; another is in Egg Harbor Township, Atlantic County.

Were always trying to figure out different ways to help the patient without hurting them, he said while petting a kitten that had been a patient for another type of treatment.

As stem cell therapy is more in the news regarding humans, a pet owners first question might be where the stem cells come from that are used in the process. The answer: from fat tissue of the pet itself, extracted and processed the same day.

As the therapy has been refined in the last decade, it has actually started to become a lot easier, more cost-effective more recently, said Pride, since weve been able to process fat tissue instead of actually getting bone marrow.

Fat tissue actually has a much higher concentration of adult stem cells than bone marrow does, so its less painful for the patient, they heal a lot easier, and we dont have to process it in a different facility.

Everything comes from the animal, and we give it back to the animal. Nothing comes from another animal. We dont have to worry about them rejecting the sample; its their own tissue, and were giving it back to them.

The pet typically goes home the same day after about eight hours. First, X-rays and a consultation with the veterinarian can determine whether the pet is a candidate for the treatment.

A pet owner may not even know that their animal has arthritis.

Cats have a lot of inflammatory issues that they tend to be very good at hiding, said Pride. A lot of people dont realize that they have arthritis. They think, oh, my cats just getting older; hes not jumping as much; hes not as strong; hes just sleeping most of the day, but actually he has arthritis. Its very difficult to diagnose in cats. A lot of times you end up having to do X-rays to find where the arthritic joints happen to be.

An inch-and-a-half incision is the minor surgery that harvests the fat tissue from the belly while the pet is anesthetized. For a cat, about 20 gramsare extracted. For a large dog, about 40 gramsare needed. While the pet is recovering from the incision surgery, the veterinary hospital is processing the sample. When the sample is ready, the pet is sedated because we then have to give them the joint injections. Then we can reverse the sedation, and they go home.

We asked the doctor if the process always works. He gave the example that on average, a dog such as a boxer that was hobbled is now able to walk without seeming like its painful. In an extreme positive case, a dog that had been barely walking might be bouncing all over the place in two months.

It doesnt always work to the extent that we would love it to, but we usually notice that there is a positive effect from it, Pride remarked. Every patient will be different in what they experience.

For the same reason that everyones situation is going to be different, cost of treatment was not given for this story.

It generally takes about 30 to 60 days for relief to show, the veterinarian said, and the animals progress will be monitored.

On average, results last about 18 months to two years before more stem cells might have to be injected. The procedure takes about an hour.

The nice thing is once we collect those stem cells (from the first procedure), we can bank the leftovers they are cryogenically stored at MediVet corporate headquarters in Kentucky and we dont have to go through the initial anesthetic surgery, said Pride.

Stem cell therapy is one of several innovative modalities available at Stafford Veterinary Hospital. Laser therapy, acupuncture and holistic medicine are others. Care for exotic pets is available, as is emergency pet care.

Visit the website staffordvet.com or call 609-597-7571 for more information on general and specialized services, including: vaccinations, microchipping, spayingand neutering, dental care, wellness exams, dermatology, gastrology, oncology, opthalmology, cardiology, soft-tissue surgery, ultrasound, radiography, nutrition, parasite control, boarding, laborand delivery, end-of-life care, and cremation.

Stafford Veterinary Hospital has been in business since 1965, founded by Dr. John Hauge. Today, five highly skilled veterinarians are on staff, and a satellite, Tuckerton Veterinary Clinic, is at 500 North Green St. in Tuckerton.

Pride has been medical director at Stafford Veterinary Hospital since 2008. He attended Rutgers University, then earned his Veterinary of Medicine degree at Oklahoma State University.

The mild-mannered doctor feels a great rewardfrom treating animals that cant speak for themselves when they feel bad.

These guys, theyre always thankful; you can see what they think, he said of treated pets. The turnaround in their attitude, the turnaround in their ability to be more comfortable, you can see it in their faces; you can see it in their actions. You learn to read animals over time.

Its knowing that were helping those who cant help themselves, he added, and you can see it in them; thats the most gratifying.

mariascandale@thesandpaper.net

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Stem Cell Therapy for Dogs and Cats Is Innovative at Stafford Veterinary Hospital - By MARIA SCANDALE - The SandPaper