Archive for September, 2019

Cushing disease is caused by tumour in the pituitary gland which leads to excessive secretion of a hormone called adrenocorticotrophic (ACTH), which in turn leads to increasing levels of cortisol in the body. Cortisol is a steroid hormone released by the adrenal glands and helps the body to deal with injury or infection. Increasing levels of cortisol increases the blood sugar and can even cause diabetes mellitus. However the disease is also caused due to excess production of hypothalamus corticotropin releasing hormone (CRH) which stimulates the synthesis of cortisol by the adrenal glands. The condition is named after Harvey Cushing, the doctor who first identified the disease in 1912. Cushing disease results in Cushing syndrome. Cushing syndrome is a group of signs and symptoms developed due to prolonged exposure to cortisol. Signs and symptoms of Cushing syndrome includes hypertension, abdominal obesity, muscle weakness, headache, fragile skin, acne, thin arms and legs, red stretch marks on stomach, fluid retention or swelling, excess body and facial hair, weight gain, acne, buffalo hump, tiredness, fatigue, brittle bones, low back pain, moon shaped face etc. Symptoms vary from individual to individual depending upon the disease duration, age and gender of the patient. Disease diagnosis is done by measuring levels of cortisol in patients urine, saliva or blood. For confirming the diagnosis, a blood test for ACTH is performed. The first-line treatment of the disease is through surgical resection of ACTH-secreting pituitary adenoma, however disease management is also done through medications, Cushing disease treatment market comprises of the drugs designed for lowering the level of cortisol in the body. Thus patients suffering from Cushing disease are prescribed medications such as ketoconazole, mitotane, aminoglutethimide metyrapone, mifepristone, etomidate and pasireotide.

Cushings disease treatment market revenue is growing with a stable growth rate, this is attributed to increasing number of pipeline drugs. Also increasing interest of pharmaceutical companies to develop Cushing disease drugs is a major factor contributing to the revenue growth of Cushing disease treatment market over the forecast period. Current and emerging players focuses on physician education and awareness regarding availability of different drugs for curing Cushing disease, thus increasing the referral speeds, time to diagnosis and volume of diagnosed Cushing disease individuals. Growing healthcare expenditure and increasing awareness regarding Cushing syndrome aids in the revenue growth of Cushings disease treatment market. Increasing number of new product launches also drives the market for Cushings disease Treatment devices. However availability of alternative therapies for curing Cushing syndrome is expected to hamper the growth of the Cushings disease treatment market over the forecast period.

The Cushings disease Treatment market is segment based on the product type, technology type and end user

Cushings disease Treatment market is segmented into following types:

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By Drug Type Ketoconazole Mitotane Aminoglutethimide Metyrapone Mifepristone Etomidate Pasireotide

By End User Hospital Pharmacies Retail Pharmacies Drug Stores Clinics e-Commerce/Online Pharmacies

Cushings disease treatment market revenue is expected to grow at a good growth rate, over the forecast period. The market is anticipated to perform well in the near future due to increasing awareness regarding the condition. Also the market is anticipated to grow with a fastest CAGR over the forecast period, attributed to increasing investment in R&D and increasing number of new product launches which is estimated to drive the revenue growth of Cushings disease treatment market over the forecast period.

Depending on geographic region, the Cushings disease treatment market is segmented into five key regions: North America, Latin America, Europe, Asia Pacific (APAC) and Middle East & Africa (MEA).

North America is occupying the largest regional market share in the global Cushings disease treatment market owing to the presence of more number of market players, high awareness levels regarding Cushing syndrome. Healthcare expenditure and relatively larger number of R&D exercises pertaining to drug manufacturing and marketing activities in the region. Also Europe is expected to perform well in the near future due to increasing prevalence of the condition in the region.

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Asia Pacific is expected to grow at the fastest CAGR because of increase in the number of people showing the symptoms of Cushing syndrome, thus boosting the market growth of Cushings disease treatment market throughout the forecast period.

Some players of Cushings disease Treatment market includes CORCEPT THERAPEUTICS, HRA Pharma, Strongbridge Biopharma plc, Novartis AG, etc. However there are numerous companies producing branded generics for Cushing disease. The companies in Cushings disease treatment market are increasingly engaged in strategic partnerships, collaborations and promotional activities to capture a greater pie of market share.

The research report presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, and statistically supported and industry-validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report provides analysis and information according to categories such as market segments, geographies, types, technology and applications.

The report covers exhaustive analysis on: Market Segments Market Dynamics Market Size Supply & Demand Current Trends/Issues/Challenges Competition & Companies involved Technology Value Chain

Regional analysis includes North America (U.S., Canada) Latin America (Argentina, Mexico, Brazil, Rest of Latin America) Europe (Germany, Italy, France, U.K., Spain, Russia, Rest of Europe) Asia Pacific (China, India, Japan, Rest of APAC) Middle East and Africa (Rest of MEA, S. Africa)

The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

Report Highlights: Detailed overview of parent market Changing market dynamics in the industry In-depth market segmentation Historical, current and projected market size in terms of volume and value Recent industry trends and developments Competitive landscape Strategies of key players and products offered Potential and niche segments, geographical regions exhibiting promising growth A neutral perspective on market performance Must-have information for market players to sustain and enhance their market footprint.

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Cushings Disease Treatment Market Size & Share Expanding Across The Globe By 2025 - Rapid News Network

On a recent episode of his Friday evening talk show, Bill Maher proposed that society combat obesity by body-shaming overweight individuals. He argued that fat shaming doesnt need to end, it needs to make a comeback to deter people from overeating.

Obesity is a national epidemic that is placing a significant burden on our health care system. Nearly 40% of Americans are considered obese, costing upwards of US$150 billion dollars per year in health costs, according to the Centers for Disease Control and Prevention.

To individuals who are not obese, it can be easy to assume that overeating is strictly a failure of willpower and discipline. However, evidence shows that body-shaming and weight discrimination are misguided approaches, and often make the problem worse. Moreover, there are multiple biological forces underlying appetite and metabolism that may be beyond a persons full control.

I am a molecular biologist with interests in the root causes of human behavior. As the author of the book, Pleased to Meet Me: Genes, Germs, and the Curious Forces That Make Us Who We Are, I have done extensive research into the biological forces that conspire to shape human personality and behavior, including the factors influencing our diet and tendency to overeat.

Maher tried to support his argument with the claim that being fat isnt a birth defect. This is not necessarily true. Some people are born with genetic variations in hormonal systems that regulate hunger and satiety. Leptin, for instance, is a hormone that tells the brain when the stomach is full. People born with leptin deficiency cannot sense when they are full and frequently overeat. Other genes linked to energy metabolism, food cravings and the brains reward response have been found to be driving factors in overeating and weight gain.

There is also growing evidence that several health conditions, including obesity, may arise from how the environment in the uterus affects the development of the fetus. A 2014 study at the University of Denver showed that prenatal maternal stress influences childhood obesity. Why should children be shamed for their mothers stress during pregnancy?

There is compelling data that the microbes in our intestines, part of our microbiome, may influence our food cravings and the tendency to overeat. Microbiologist Jeffrey Gordon at Washington University has conducted pioneering studies charting differences in the bacterial species inhabiting the guts of lean versus obese people.

Gordon and his team also transplanted intestinal bacteria from lean or obese people into the guts of mice. For the study, the intestinal bacteria were harvested from identical twins in which one was obese and the other lean. The result: While gut bacteria from the lean twin kept mice lean, gut bacteria from the obese twin led to obesity in the mouse. These findings provide evidence that the types of microbes in our gut influence our metabolism and contribute to our weight.

It is also well-established that certain medications, like steroids, alter metabolism and fat deposition, leading to weight gain. Brain injury and tumors can also induce overeating and obesity. While these causes of obesity are less common, I think it is unfair to make assumptions that obese individuals are in full control of their behavior.

Body-shaming is not only ineffective but frequently backfires. In a 2013 study, researchers at Florida State University revealed that people subjected to weight discrimination were three times more likely to remain obese. A year later, researchers at University College London added more supporting evidence; rather than helping people lose weight, weight discrimination promotes weight gain.

Most recently, a 2019 study showed that weight discrimination significantly contributed to an overall health decline in all participants. In addition to weight gain, multiple studies have shown that body-shaming also harms psychological health, frequently leading to depression.

There are more effective, not to mention more compassionate, ways to help those struggling with obesity. As British physician Stephen ORahilly has written, The growing evidence that humans can be genetically hardwired to become severely obese should eventually lead to a more widespread realization that morbid obesity is a disease requiring further scientific research, rather than a failure of willpower requiring sanctimonious moral opprobrium.

Bill Sullivan, Professor of Pharmacology & Toxicology, Indiana University.

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Heres why Bill Maher is wrong about fat-shaming - AlterNet

Dr. Patricia Coughlin, sole owner of Good Karma Dispensary, has applied for a dispensary facility license in Brentwood, Missouri. Like the other 2,300 applications, she awaits licensing results from the state. Coughlin is one of over 1,000 applicants applying to open a medical marijuana dispensary in Missouri.

The 83-year-old has lived in St. Louis her entire life. She was a registered nurse for 44 years and a social worker for 39 years. She has her doctorate in social work. Dr. Coughlin is a captain in the United States Army Nurse Corps; a former professor at Washington University, University of Missouri-St. Louis, and Maryville University; and even formerly hosted a local radio show.

I believe that my unique background, combined with my extensive knowledge in the area of medical marijuana will be to serve my dispensary clients well, Dr. Coughlin told Greenway Magazine. As a senior, I intend to focus quite a bit on the more mature population that does not feel comfortable with many of the stereotypical associations of marijuana. I believe it is important to promote the message that medical marijuana is an acceptable alternative to traditional pharmacology, and I hope my messages will help to de-stigmatize medical marijuana.

She said her reason for applying for a facility license comes down to her first-hand accounts of the needs of the aging community and a need for alternative treatment options.

My main reason for applying for a dispensary license is that I see first hand every day the significant need in the aging community for a healthier alternative to dangerous prescription medications to treat: sleep problems and insomnia, loss of appetite, chronic pain from age-related conditions, depression, and the agitation and other symptoms related to Alzheimers, Dr. Coughlin said. The aging population, in my opinion, is the most needlessly over-medicated and is in dire need of alternatives.

A way she plans for her dispensary to serve aging patients better is by offering a VIP Service where her or another nurse will meet in-home with families and patients to discuss treatment.

I will work in conjunction with the patients physician and healthcare team to determine the best course of medical marijuana treatment, Dr. Coughlin said. I will follow up weekly with family members to assess progress, changes, and any concerns as well as to personally deliver the product to the family/patient and assist with teaching and training on side effects, symptoms, etc.

Dr. Coughlins dispensary also plans to make specific offerings for fellow veterans, including discounts and outreach. She will be providing lectures and visiting support groups touting the benefits of medical marijuana to treat post-traumatic stress disorder and other conditions unique to veterans.

Her outreach will further extend into the healthcare industry, where she plans to capitalize on her almost 50 years of nursing experience. She will also be providing workshops and seminars for counselors, social workers, therapists, psychologists, and psychiatrists to increase regional education for medical marijuana treatment for mental illness.

Her experience and multi-faceted outreach strategy is one that Dr. Coughlin hopes will make her application stand out.

Outside of her care experience, Dr. Coughlin founded the Magdala Foundation, the first halfway house for female offenders in the United States, for which former St. Louis Mayor A.J. Cervantes awarded her the key to the City.

Additionally, she co-founded The PMS Center, one of the first facilities of its kind in the country to treat women suffering from PMS and other hormone-related conditions. She emerged early on as an expert in PMS and bio-identical hormones, appearing on several national television shows. She volunteers as a counselor at Birthright Crisis Pregnancy Counseling and she is on the Board of Missouri Right to Life.

Her dispensary proposal, of which she is the sole owner and funder, has been welcomed by the City of Brentwood and local residents.

Dr. Coughlin is an active longtime member of the St. Louis Arch Diocese and a longtime serial entrepreneur. She is the mother of five professional adults and grandmother to 15, all living in the St. Louis area.

Continued here:
Longtime St. Louis nurse says Good Karma is about 'healthier alternatives' - Greenway

HCG (Human chorionic gonadotropin) is one of the fastest andeasiest ways to lose weight up to 3lbs per day for the first week. Nowadays,this protocol of weight loss has become popular among those who search for thequickest weight loss products out there in the market. HCG is a kind of hormonethat can be found in the placenta of pregnant women. In her pregnant period,the production of this hormone increases at its highest level. It sends themessage of a woman not to menstruate.

In comparison to other weight loss products in the market, HCG works faster. Thats why; its demand is on the rise at present. It is available as a form of sprays, drops, and injections. By eliminating cravings and controlling hunger for foods, HCG drops help you to lose weight according to your need.

It is also called an ultra-low-calorie diet which allows itsuser to consume only 500 calories per day as long as he or she is on this dietplan. As HCG helps to boost metabolism in your body, it works as a weight-losssupplement all without making you hungry.

If somebody takes the HGC diet plan and can keep stickduring this plan, he or she can lose 5 to 40 pounds or more. In the first week,you may end up losing nearly 3 to 4 pounds if it is your first time. And youhave to continue this diet plan (3 or 6 weeks) until it finishes following thediet plan. If you think that you have already burnt enough fat and fail tofollow the extreme diet plan, you will end up gaining more weight.

HCG, a very low-calorie diet comes up with three main stages you need to follow strictly. These include loading phase, weight loss phase, and maintenance phase. All three stages are equally important to observe. If you fail to maintain any of them, you will end up gaining some extra weight.

This is the phase where you are permitted to takehigh-calorie and high-fat foods just for two days after starting the HCG dietplan to lose weight.

This is the most crucial phase you have to followappropriately without making any mistake. Along with taking HCG, it will allowyou to choose only 500 calories each day for 3 to 6 weeks. You can have twomeals per day- lunch and dinner. You may think that this extreme diet plan willleave you to make hungry. HCG diet plan will not allow you to crave or make youhungry for foods.

In this phase, you can increase food intake and stopconsuming HCG. It does not mean that you can eat as much as you wish. For thenext three weeks, you have to avoid sugar and starch to maintain the phase.Otherwise, you will gain weight fast indeed.

Phase 3 should be the most crucial part of the HCG diet plan. Some people regain their weight during phase 3 because they start consuming sugar and starch randomly. To maintain the weight you have achieved during the diet plan, you have to eat foods that are recommended for phase 3. You should also be aware of including new food items into your diet. Instead, you can gain 2 pounds of weight more if you do not follow the instruction during this phase.

If you aim to lose weight within the shortest possible time,there is no alternative to HCG. Yes, it is a solid diet plan because itsinstructions are rigorous but concise. If you can follow all itsrecommendations while taking this extreme diet plan, you are sure to burn yourextra fat up to 40 pounds or even more.

Its beginning is faster than the later phases. At thebeginning of any diet plan for weight loss, all you lose is water from yourbody. You can eat fats as well as healthy foods you like once you have finishedthe diet plan. But you have to make sure that you are not overeating.

Losing extra weight is beneficial for your body. It iseasier to perform actions of your day to day life if you are not too bulky.Everyone under the sun wants to have a good appearance. But doing things toofast also leave you with some side effects.

So, it would be wise to consult with your physician beforetaking any diet plan. Your doctor knows it very well whether your body is up tothe mark to continue with the extreme-low diet plan, HCG. If it does not suityou, you will have some health conditions including headaches, depression, orfatigue.

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How much weight can you lose on the HCG diet? - VIVA GLAM MAGAZINE - vivaglammagazine.com

Steroids can be defined as a kind of natural or synthetic chemical compounds that can be produced naturally in the body as well as artificially in the laboratories.

Steroids help the cells, tissues, and organs to function properly and they are also used to treat various medical conditions. The two primary sorts of steroids are corticosteroids and anabolic-androgenic steroids which is also called anabolic steroids.

To decide which steroids are legal is a tricky one. The term legal steroids is a catch-all for muscle-gaining supplements that are not considered illegal. Legal steroids are also called Multi Ingredient Pre-Exercise Supplements (MIPS) and Over-The-Counter (OTC) health supplements.

These health supplements are intended to help with weight-lifting, developing muscles, and improve performance and stamina of athletes. Anabolic-androgenic steroids are engineered (artificial) renditions of the male sex hormone testosterone.

Medical practitioners prescribe these hormone enhancing steroids to individuals who have muscle atrophy or problems in producing enough testosterone. However, numerous reports and cases have come to light where athletes and bodybuilders have been found to use these steroids unlawfully to boost performance or grow muscles.

There are two sorts of steroids present inside the body. The adrenal organ situated over the kidney in our body produces corticosteroids. These hormones comprise of aldosterone, which plays a vital role in controlling the concentration of sodium in the body, and cortisol, which acts as the bodys stress reaction framework to reduce inflammation.

Corticosteroids are prescribed by medical practitioners to treat illnesses like asthma, bowel ailment, rheumatoid joint inflammation, and a number of ailments.

Anabolic or anabolic-androgenic steroids are produced artificially that copies characteristics of the male hormone testosterone in its capacity to build muscle tissue and in the development of the features of male secondary sex. Different types of medical conditions such as hypogonadism, osteoporosis, malnutrition, anemia, HIV (Human Immunodeficiency Virus), and breast cancer.

Corticosteroids are used as medicines that help combat inflammation in our body. These steroids are made in laboratories and perform just like the cortisol hormone that is produced inside our body. Cortisol or corticosteroids like the drug prednisone prevent our immune system from producing inflammation-causing substances.

Corticosteroids medically help treat conditions that cause swelling and irritation. They also help ease side effects of asthma, multiple sclerosis, rheumatoid inflammation of joints, skin conditions like dermatitis, short-term treatment of allergic reactions like poison ivy rash, lupus vulgaris or lupus erythematosus, chronic obstructive pulmonary disorder (COPD).

Regular intake of high doses of corticosteroids for quite a while can cause severe symptoms like osteoporosis, impedes the development in children, and also cause adrenal deficiency which is a deadly condition where the bodys stress reaction capacity stops it can no longer respond to illnesses or surgical procedures.

Other long-term effects of taking corticosteroids include eye problems like cataract, loss of muscle strength, and also a higher possibility of suffering from diabetes.

The anabolic or androgenic steroids are artificially composed to mimic the characteristics of testosterone hormone that is produced in the testicles and ovaries.

The androgenic compound of the testosterone hormone is associated with building up the male sex attributes, while the anabolic part is engaged with expanding the volume of body tissue by accelerating protein generation. The pituitary organ, situated at the base of the cerebrum, manages testosterone generation and hormone discharge.

Medical practitioners might advise the use of anabolic and androgenic steroids as prescription drugs for individuals whose body is not capable of producing enough hormone which is why they might need hormone supplements.

The anabolic steroids are recommended by medicinal services providers as legal prescription drugs, yet this type of medications is frequently mishandled and illegally consumed escalate performance of athletes and also develop physical appearance like muscle building.

At the point when utilized in a well-sustained body, anabolic steroids will cause weight gain to encourage an expansion in muscular tissues.

While anabolic steroids may have positive impacts when taken under the supervision of a physician, they have numerous severe and at times irreversible reactions. These reactions are caused because of the unusually abnormal accumulation of testosterone in the body and may result in hypertension, raised cholesterol levels, liver ailments, cardiovascular illness, skin inflammation, hair loss, and certain behavioral syndrome. The anabolic steroids are available in many different types.

Some copy the activities of testosterone, while others cause the body to create abundance testosterone by meddling with the typical hormone-producing system in the body.

No matter what the purpose of these steroids are, the excessive amount of testosterone-induced in the body always ends up in affecting the normal functioning of cells and organs in the body.

Anabolic steroids are usually prescribed to be taken orally or injected in the muscles, especially for individuals whose body does not produce enough testosterone. Medical practitioners also recommend them to individuals who have lost muscle strength due to chronic health conditions like cancer and AIDS. AIDS, and other wellbeing conditions.

High doses of anabolic steroids taken for a long time can harm our liver, kidneys, and heart. It can also cause heart failure and swelling of the heart because of extreme fluid retention. These medications can likewise raise the level of LDL cholesterol, which can cause strokes or heart attacks in individuals of any age.

Conclusion

It is safe to say that steroids irrespective of their legalities are never the best answer for growing muscles or keeping the body fit. They can cause many harmful reactions that may compromise the state of our wellbeing in the long haul.

Steroids are drugs that cause strong reactions in the body, and they can cause cataracts or illnesses of bones like osteopenia. Therefore, it is always ideal to concentrate on manageable, sound approaches to build muscles and remain fit.

This will not only prevent any additional physical and mental damage due to the dependence on synthetic chemicals to enhance physical stamina but also allow the cells and organs of our body to function normally.

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What Are Steroids and Are They Legal? - The Vistek

NEW YORK A recent pilot study of Pfizer's PARP inhibitor talazoparib (Talzenna) suggests that it might work as a neoadjuvant treatment for women with triple negative breast cancer and BRCA germline mutations.

Pfizer is conducting its own Phase II trial, results of which are still likely more than a year away, but the pilot, conducted by researchers from MD Anderson Cancer Center, showed promising results.

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Post menopause is the period occurred after menopause followed by various syndromes like vaginal dryness, hot flashes, etc. During this period level of estrogen and progestin falls significantly leading to even serious complications like osteoporosis. The worldwide market for Postmenopausal Hormone Therapy is gaining moment substantially. This rising demand for Postmenopausal Hormone Therapy is due to increasing level of awareness about menopausal symptoms and its treatment. Another factor is growing population of post-menopausal women. Postmenopausal Hormone Therapy includes replenishment of body level of estrogen and progestin hormones in women through external intake of hormones. Thus, it help in treating the menopausal symptoms. It decreases the symptoms like vaginal dryness, hot flashes, disturbed sleep, night sweats and etc. The Postmenopausal Hormone Therapy helps in prevention of osteoporosis and hot flashes caused due to depletion of estrogen and progestin level in body. The Postmenopausal Hormone Therapy comprises of natural as well as synthetic estrogens. In order to enhance the menopausal treatment, it is also given in combination with progesterone.

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The treatment for post menopausal syndrome is generally treated with sequential or continuous schedules through various doses of estrogen, progestin or combination of both. Despite of existing controversy and confusion about the safety profile of the postmenopausal hormone therapy, the market for the postmenopausal hormone therapy has recorded positive inclining growth due to growing demand. The development of postmenopausal hormone therapy with respect to driving demand leads to introduction of highly safe treatment options to patients which include development of novel drug delivery system like vaginal estrogen drugs and transdermal estrogen patches. Low dose postmenopausal hormone therapy are used in order to address the backdrop caused due to safety issues. The non-hormonal treatment has comparatively least efficacy to produce optimum results, hence the postmenopausal hormone therapy market is observed to grow significantly.

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However, the major retarding factors to the market include the affordability to the therapy. The cost for postmenopausal hormone therapy approximately revolves around US$ 10,000 per annum, and thus incurring a major burden on the patients pocket. Thus the population from developing and under developed countries faces a challenge of affordability for the postmenopausal hormone therapy. The post treatment risk of cervical cancer and coronary disease are another restraining factors for the market. Approved recognition of the products related to postmenopausal hormone therapy in compounding pharmacies particularly from developed countries is another deterring factor. However the opportunity for the market is the introduction of the product targeting the cardiovascular disease prevention.

The Postmenopausal Hormone Therapy market can be segmented by product, by therapy, by dosage form, by route of administration, by end-user and by geography. In the terms of product, the postmenopausal hormone therapy is classified into patches, tablets, creams, suppositories, and injections. The tablet formulation comprises the largest market share of the total postmenopausal hormone therapy market. However, due to growing concern of safety and long-term therapy the market for the patches are growing at much faster compound annual growth rate. Based on the therapy, the market is segmented into individual progestin, estrogen and combination therapies. The majority of market is occupied by estrogen therapy across the world.

Based on the route of administration, the postmenopausal hormone therapy market is classified into oral, topical and subcutaneous implants. Due to high safety, oral administration has been the preferred choice of option for the patient. However, introduction of novel drug delivery system has driven the market for topical and subcutaneous products as well. In the terms of end-user, the target population are the women suffering from menopause. However, the treatment is influenced by the physician/ gynecologist, the target end-users are hospitals and specialty clinics.

Geographically, North America occupies the largest market share followed by other developed region like Europe. The United States accounts for a major share of the global market. The high awareness level and high purchasing power in this region led the market of postmenopausal hormone therapy for expansion significantly. However, the same factor of affordability has restrained the markets in developing regions. Despite of this, Asia Pacific has shown striking increase in its growth rate for the postmenopausal hormone therapy market. Rising population, increase in disposable income, and increase in awareness level are some key factors driving the Asia Pacific Market. Due to this factors, the Asian market is observing high number of new entrants compared to those in developed regions.

The Major players reported in the market include Abbott Laboratories, AbbVie, Inc., Bayer Pharma AG, Hisamitsu Pharmaceutical Co., Inc., Novartis AG, Novo Nordisk A/S, Orion Pharma AB, Pfizer, Inc., Meda pharmaceuticals, Teva Pharmaceutical Industries Ltd. and TherapeuticsMD, Inc., etc

Link:
Postmenopausal Hormone Therapy Market to Surge at a Robust Pace by 2024 - Market Reporter

Report Title: 2019-2024 Global and Regional Endocrine Testing Industry Production, Sales and Consumption Status and Prospects Professional Market Research Report

Endocrine Testing Market research report gives detailed information of major players like manufacturers, suppliers, distributors, traders, customers, investors and etc. Endocrine Testing market Report presents a professional and deep analysis on the present state of Endocrine Testing Market that Includes major types, major applications, Data type include capacity, production, market share, price, revenue, cost, gross, gross margin, growth rate, consumption, import, export and etc. Industry chain, manufacturing process, cost structure, marketing channel are also analyzed in this report.

Overview Of Endocrine Testing Market:

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Report further studies the Endocrine Testing market development status and future trend across the world. Also, it splits Endocrine Testing market by type and by applications to fully and deeply research and reveal market profile and prospects.

Segmentations Analysis:

Top Key Players:Abbott Laboratories, AdnaGen, Beckman Coulter/Danaher, Biomedical Diagnostics, BioMerieux, Bio-Rad, Dako, DiaSorin, Eiken, Fujirebio, Instrumentation Laboratory, Kyowa Medex, Matritech, Ortho-Clinical Diagnostics, Roche, Siemens, Sysmex, Thermo Fisher, Tosoh, Wako, Wallac/PE

By TestEstradiol (E2) Test, Follicle Stimulating Hormone (FSH) Test, Human Chorionic Gonadotropin (hCG) Test, Luteinizing Hormone (LH) Test, Dehydroepiandrosterone sulfate (DHEAS) Test, Progesterone Test, Testosterone Test, Thyroid Stimulating Hormone (TSH) Test, Others (Gastrin, Thymosin, Secretin, etc.)

By TechnologyTandem Mass spectrometry, Immunoassay (Enzyme immunoassays, Radioimmunoassays (RIA)) Technologies, Monoclonal and Polyclonal Antibody Technologies, Sensor (Electrochemical, Biosensors, etc.) Technologies, Clinical Chemistry Technologies, Others (Liquid Chromatography + Mass Spectrometry (LC-MS)

By End UserHospitals, Commercial Laboratories, Ambulatory Care Centers, Home Based Tests, Physician Offices.

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Endocrine Testing Market report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business distribution etc., these data help the consumer know about the competitors better. This report also covers all the regions and countries of the world, which shows a regional development status, including market size, volume and value, as well as price data.

Geographically, this report is segmented into severalkey regions, with sales, revenue, market share and growth Rate of Endocrine Testing in these regions, from 2014 to 2024, covering

The Endocrine Testing market report provides answers to the following key questions:

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Detailed TOC of 2019-2024Global and Regional Endocrine Testing Industry Production, Sales and Consumption Status and Prospects Professional Market Research Report

Chapter 1 Industry Overview

Chapter 2 Production Market Analysis

Chapter 3 Sales Market Analysis

Chapter 4 Consumption Market Analysis

Chapter 5 Production, Sales and Consumption Market Comparison Analysis

Chapter 6 Major Manufacturers Production and Sales Market Comparison Analysis

Chapter 7 Major Type Analysis

Chapter 8 Major Application Analysis

Chapter 9 Industry Chain Analysis

9.2 Manufacturing Analysis

9.3 Industry Chain Structure Analysis

Chapter 10 Global and Regional Market Forecast

10.2 Sales Market Forecast

10.3 Consumption Market Forecast

Chapter 11 Major Manufacturers Analysis

11.1 Company 3

11.2 Company 2

11.3 Company 3

Chapter 12 New Project Investment Feasibility Analysis

Continued.

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Endocrine Testing Market Report 2019 to 2024 With Top Countries Data : Growth, Provides Analysis on Supply, Market Size, Import and Export,...

Health and fitness expertJillian Michaelsis opening up about struggling with the hormonal disorder PCOS (polycystic ovary syndrome) as a teenager.

PCOS is common, affecting 1 in 10 women of reproductive age, according to theU.S. Department of Health and Human Services. Women with PCOS can have irregular menstrual cycles and higher levels of the male hormone androgen, according to theMayo Clinic. The condition can also cause women to develop ovariancysts.

Michaels learned she had PCOS at 15 years old in an incredibly painful way. I discovered it because I had a cyst burst on one of my ovaries, Michaels shares with Yahoo Lifestyle. She was in so much pain that her mother thought Michaels appendix was bursting. Michaels was rushed to the emergency room where doctors discovered it was a cyst that had burst.

Her doctor suggested she go on birth control pills a common treatment for PCOS that helpsregulate periodsand lower androgen levels. But Michaels didnt want to take the medication.

She continued to develop cysts. When she was 21 years old, Michaels experienced a burst cyst yet again, which was her wakeup call. And then I began to try to understand it, she says, referring to the condition. Instead of throwing more drugs at the problem, I looked at why does the problem exists.

She found out that PCOS is linked to insulin resistance. In fact, according to theCleveland Clinic, insulin resistance is one of the root physiological imbalances in most, if not all, PCOS.

By changing her diet, Michaels thought she could sensitize her body to insulin. No fake sugars, no processed sugars, no processed grains things that drive insulin to the roof, she says. And over time, I pretty much had the situation under control. Her lifestyle changes had a dramatic impact on her health. I havent had an issue in about 20 years, she says. Its about eating right, working out, and eating clean. A lot of chemicals that are in our food wreak havoc on your endocrine system.

However, Michaels clarifies one thing about her choice not to take birth control pills to help her PCOS back when she was a teenager: Im not saying if your doctor puts you on a birth control pill, say no, she says. Im just saying for me personally, I was able to manage the situation with lifestyle.

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Jillian Michaels shares how changing her diet helped her PCOS: I havent had an issue in about 20 years - Yahoo Lifestyle

New research suggests that women who take birth control pills are at a higher risk for developing type 2 diabetes (T2D), even after controlling for weight, family history of type 2 diabetes, blood pressure, and smoking.

The study, presented at the European Association for the Study of Diabetes (EASD) in Barcelona, Spain, on September 16, 2019, also showed that women who go through puberty and menopause later have a lower risk of developing type 2 diabetes.

RELATED: Hormones and Your Health: An Essential Guide

These findings support earlier research on the protective value of longer exposure to ones own sex hormones, says Stephanie S. Faubion, MD, the medical director of the North American Menopause Society and the director of the Mayo Clinic Center for Womens Health in Rochester, Minnesota. Dr. Faubion was not involved in this research. These results may help clinicians identify women with greater risk for diabetes in whom more aggressive lifestyle modification may be needed, says Dr. Faubion.

The research, set to be published in the journal Diabetologia, looked at 83,799 French women from the E3N prospective cohort study who were followed between 1992 and 2014. Through the use of computer modeling, scientists were able to adjust for type 2 diabetes risk factors such as smoking, age, physical activity, family history, blood pressure, education level, and socioeconomic status in order to find out how different hormonal factors impact a womans risk of developing type 2 diabetes.

RELATED: Quiz: Are You At Risk for Type 2 Diabetes?

There were several factors that were associated with a lower risk of developing T2D, including:

These findings are consistent with those of the Womens Health Initiative (WHI) trials, which suggested reduced risk of diabetes in women using menopausal hormone therapy, saysFaubion. In that large-scale long-term study, researchers found that women taking estrogen plus progestin reduced their risk for developing T2D by 14 to 19 percent.

RELATED: Later Menopause Linked to Better Memory, Study Shows

There are different theories on why estrogen might help reduce the risk of diabetes, says Sopio Tatulashvili, MD, an endocrinologist at Avicenne Hospital, Bobigny, France, and the lead author of the research. Pancreatic islet cells, important in regulating insulin secretion and glucose metabolism, contain estrogen receptors.It is hypothesized that when estradiol (a form of estrogen) interacts with those receptors it can help with the survival and stability of islet cells and in stimulating insulin synthesis, which aids glucose metabolism. This could make developing diabetes less likely, says Dr. Tatulashvili.

Estrogen also seems to increase insulin sensitivity and our muscles ability to efficiently metabolize glucose, which would also make the progression to diabetes less likely, she adds.

RELATED: The Possible Benefits of Metformin for Type 2 Diabetes and Other Health Conditions

Its not surprising that women who have less exposure to their own sex hormones have an increased risk of developing type 2 diabetes, says Faubion. We see this same effect with other chronic diseases, especially if estrogen is lost early as in the case of early or premature menopause, says Faubion. Research has established a clear link to early loss of hormones (early or premature menopause-ovaries removed early) and accelerated aging and development of chronic diseases, including increased risk for heart disease, osteoporosis, dementia and even early death, says Faubion, who coauthored research on the potential long-term health consequences of early menopause.

A study published in Diabetologia in October 2017 found that women who had natural menopause at an earlier age (age 44 or younger) were at a higher risk for developing type 2 diabetes.

RELATED: 10 Ways to Beat Menopausal Belly Fat

The study also found that the use of birth control pills at least once was associated with a 33 percent increased risk of developing type 2 diabetes compared with women who had never used them. Risk induced by oral contraceptives could lead to personalized advice for young women at risk of developing T2D, such as those with a family history of diabetes, those who are overweight or obese, or those with polycystic ovary syndrome, said the authors.

Its not clear why birth control pills could increase risk, but it may potentially relate to the progestogen component of the oral contraceptive pill (OCP), and so risk may vary based on type of progestogen found in the OCP, says Faubion. In any event, women should not alter their decision-making regarding their contraceptive method based on these results, she added.

RELATED: The Best and Worst Birth Control Options

Tatulashvili agrees there is no clear explanation why contraceptive pill use is associated with higher risk of type 2 diabetes. Another hypothesis is that birth control pills can lead to higher than normal estradiol levels, which could cause insulin resistance in the liver or a reduction in the efficiency of glucose use and transport in muscle cells, says Tatulashvili.

More research is needed on the influence of each type and exposure of contraceptive agents before translating these findings into clinical practice and prevention strategies, says Tatulashvili.

Originally posted here:
Diabetes Risk Is Related to Hormones in Women - Everyday Health

The Ballston building that used to house canceled chef Mike Isabellas Pepita is changing from a cantina that used to deliver toxins to customers livers into an anti-aging and wellness center that injects toxins directly into peoples faces. ARLnow reports that D.C.-based Javan Wellness, which offers services including botox, dermal fillers, IV hydration, and hormone replacement therapy, is targeting an October opening in the space at 4000 Wilson Boulevard in Arlington.

Pepita was part of a complex of three Mike Isabella Concepts restaurants in Arlington that closed earlier than expected in December following a bankruptcy filing amid a scandal stemming from allegations of sexual harassment that a former MIC manager brought against Isabella and his deputies. The Mexican restaurant opened in 2015.

Many of Isabellas former properties are still stagnant, and the companys assets have all been auctioned off in pieces. New York-based Urbanspace has taken over the Isabella Eatery in Tysons Galleria, bringing in an impressive collection of D.C. area chefs but running into its own lawsuit drama. The Hilton Brothers are putting a French bistro into the former Requin Brasserie, the first Isabella restaurant to close, in Virginias Mosaic District development. [ARLnow]

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A Former Mike Isabella Restaurant in Ballston Will Now Serve Botox Instead of Margaritas - Eater DC

A Bangor clinic that has long provided abortions and other health services for women will soon offer its first birth control procedure for men.

In October, a nurse practitioner at the Mabel Wadsworth Center will begin performing vasectomies on men as well as on transgender women as part of its growing mission to meet the sexual and reproductive health needs of all genders and identities, according to Executive Director Andrea Irwin.

Weve seen a lot of folks come in with an unintended pregnancy and their partner is waiting to get a vasectomy, Irwin said. Weve heard its hard to get into places [for the procedure], so it made sense to look into offering it. And as a provider that serves a lot of trans clients, we want to serve trans women in a place thats open and affirming.

Irwin said that the new offering will advance the clinics bedrock feminist mission by forcing sexual partners to bear more of the responsibility for preventing pregnancy.

By offering vasectomies, the group also hopes to bring in a new funding stream to support its core mission of offering abortions, as it has been doing since 1994, and other services such as birth control and pregnancy and STD testing.

A vasectomy is a surgical procedure that blocks sperm from leaving the bodies of men and transgender women by snipping and sealing the tubes connecting their testicles to their urethral opening, according to the Mayo Clinic.

Although vasectomies can be reversed, health professionals generally urge patients to view it as a permanent procedure that they should only pursue if they want to give up the ability to induce a pregnancy.

At the Mabel Wadsworth Center, the operation will generally require three appointments: an initial consultation, the procedure itself and a followup visit. The nonprofit organization will accept MaineCare or private health insurance for the service, and patients who are paying out of pocket may qualify for discounts depending on their income level.

Patients whose annual income is at or below 150 percent of the federal poverty level that level works out to $18,735 for an individual in 2019, according to HealthCare.gov will be able to pay $525 for the vasectomy. Thats the same price the center charges anyone for an abortion.

The out-of-pocket cost for other patients seeking a vasectomy would be $750 if their income is at or below 250 percent of the federal poverty level $31,225 for an individual and $1,000 for everyone else.

Those numbers could change as the center begins to see how much reimbursement it collects from patients with insurance, Irwin said.

We want to send the message that everyone deserves access to reproductive health care, regardless of gender identity, where they live, their income level, she said.

Maines two other abortion providers, Maine Family Planning and Planned Parenthood, do not currently offer vasectomies at their locations in the Pine Tree State, according to their websites.

While vasectomies will be the first birth control service available to men at the Mabel Wadsworth Center, the clinic has begun offering STD testing and treatment to men in recent years. As it branches out, it has also begun offering hormone therapy for transgender people, prenatal care and mental health counseling.

It recently hired a nurse practitioner to serve as the centers clinical director, according to Irwin. It also now employs an advocate who can help connect patients to resources such as MaineCare, the states version of Medicaid.

Irwin said that a combination of grant funding and the states expansion of Medicaid under Gov. Janet Mills has helped the Mabel Wadsworth Center afford to start its new programs.

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Bangor's longstanding abortion provider will soon offer vasectomies - Bangor Daily News

The oldest members of the millennial generation are now 38 years old, according to Pew Research Center's definition.

That means many of them will soon be experiencing menopause, or the end of a woman's reproductive period. Menopause typically occurs between the ages of 45 and 55, according to the National Institute on Aging.

Menopause is often considered a taboo topic because of our youth-worshipping culture, and medical students aren't always educated on the condition and how to help patients who have it, according to Dr. Mary Jane Minkin, a gynecologist and professor at Yale University.

To break down the stigma, Minkin said patients should ask for more menopause information.

Here are some things about delaying menopause and handling symptoms you should know right off the bat.

Genetics, cancer therapies, and whether you've had a hysterectomy all play a role in when you'll go into menopause since these factors affect your hormone levels.

Your weight and cigarette-smoking habit could play a role in when you get menopause, according to a Minkin. If a person were to stop smoking or lose weight (if they're overweight), it could delay menopause onset one to two years.

Read more: 8 answers to common questions about ovulation you've been too afraid to ask

In the months and years leading up to menopause, a woman might experience irregular periods, hot flashes, vaginal dryness, sleep disturbances, and mood swings, according to The North American Menopause Society. It's all caused by hormone fluctuations during this time, called perimenopause.

These issues can persist for many years after menopause, Minkin said. But there are ways to decrease symptoms, including lifestyle changes and medications.

In addition to potentially bringing on menopause sooner than usual, smoking can also make symptoms worse.

"Smokers have much worse hot flashes than non-smokers, so if you stop smoking, not only is it good for you, but also your hot flashes," Minkin said. The same goes for weight loss in overweight people.

Hormone therapy uses progestin and estrogen to help decrease symptoms like hot flashes, but is underused because of the Women's Health Initiative, a National Institutes of Health-funded group of studies published in 2002. The report said estrogen therapy could increase a woman's breast cancer risk and scared many people away from hormone therapy.

The 2002 report has since been debunked and hormone therapy is now recognized as a safe treatment for menopause symptoms, especially hot flashes.

"Unfortunately, the bad press about estrogen has persisted for a number of years, but now we're getting better," Minkin said. "Estrogen really can be your friend."

Other medications used off-label, like the seizure medication gabapentin and the high blood pressure medication clonidine, may also help prevent or lessen hot flashes, according to the Mayo Clinic.

If you have these symptoms and want treatment, discuss options with your healthcare provider.

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How to treat hot flashes, vaginal dryness, other menopause symptoms - INSIDER

(Photo : Photo by Ahmed Carter )

Polycystic ovary syndrome (PCOS) is a condition that affects about 4% to 10% of women. Both men and women produce androgen type hormones but men usually produce more androgens and women normally produce more estrogens. However, in some cases, women may produce too many androgen hormones, so that their testosterone levels are higher than normal.

The problem with PCOS is that it actually leads to alopecia like that seen in men. This means that there is often hair lost from the head in a similar fashion to that seen in men with androgenetic alopecia. The hormonal disruptions and increased androgen production that is seen in women with PCOS has also been linked to the development of other problems such as insulin resistance and increased inflammation in the body.

The hyperandrogenism actually impacts the hair follicles causing the thinning and loss of hair on the scalp. Although women with PCOS show male pattern hair loss on their scalp, elsewhere they grow excess body hair. They also tend to have more acne breakouts than other women and often gain too much weight.

PCOS is a condition that a woman should seek treatment for because it causes so many problems, and can even cause infertility and increases the risks of getting endometrial cancer. Treatment options vary but almost all doctors recommend changes in lifestyle such as increasing the amount of exercise and eating healthy, nutritious foods.

Besides lifestyle changes, birth control can be prescribed to help regulate hormone levels and to increase and control the levels of the female sex hormones, estrogen and progesterone. Women who have PCOS and who are trying to get pregnant are often put on fertility drugs since the condition frequently lowers fertility making pregnancy difficult.

The hair loss can be treated in a variety of ways including by getting hair transplant surgery. There are some medications as well that may be helpful for your hair, such as spironolactone, minoxidil and finasteride. The problem is that there are often unpleasant and unwanted side effects associated with taking these medications. They also may be a problem if you plan on becoming pregnant. You can read more about hair loss treatment options if you have PCOS by visiting the Vera Clinic.

There are other options for treating hair loss problems caused by PCOS. Some women may opt for laser light treatment or even plasma-rich platelet therapy. The PRP does offer a good option since it is autologous, meaning it uses your own blood supply so there is no risk of tissue rejection because of your body's immune system. PRP does help to stimulate the growth of your skin and hair follicles and can produce good results.

Another possibility for women who have lost hair due to PCOS is to have a hair transplant procedure such as Follicular Unit Extraction (FUE). This is a popular type of hair transplant procedure that is commonly used to treat alopecia in men and women. The results can be very good, but it does take time for the hair to grow in.

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How PCOS Can Cause Hair Loss - Youth Health Magzine

Global Thyroid Hormone Disorder Drug Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2024 is a powerful tool that market participants can use to secure a strong position in the global Thyroid Hormone Disorder Drug market. The report studies the market status and growth opportunities from different outlooks such as from the key players angle, topographical regions, and type and application segments. The report sheds light on the market segmentation, market dynamics, the competitive landscape, manufacturing cost structure, marketing channels, and regional growth. It offers critical elements of a combined database of even supply-demand ratio. A SWOT analysis was used to bring out power, weaknesses, opportunities, and risks of the leading vendors. The research study is a great combination of both statistically relevant quantitative data of the industry and insightful qualitative comment and analysis

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The analysts have provided key development strategies including long and short-term strategies, as well as other vital competitive factors of leading businesses the company profiling section of this report. In addition, the market share of companies is also given to having a broader overview of the key players in the Thyroid Hormone Disorder Drug Market. Leading vendors covered in the report are: Novo Nordisk, Sanofi, Merck, Eli Lilly, AstraZeneca, AbbVie, . Each player/ manufacturer revenue figures, growth rate, and the gross profit margin is provided in easy to understand format.

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Next section of the study covers technology roadmap, supply chain analysis, and historical study. The supply chain analysis section includes key retailers and distributors, key manufacturers, and raw material suppliers, and gross margin. The analysis of parent industry covers opportunity, market size and forecast for 2019 to 2024. While focusing on global export, import, sales, and production, the report has considered current and future supply and demand scenarios.

This research will help you to establish a prospect of industrial development and properties of the Thyroid Hormone Disorder Drug market. Industry advancement and perceptive examination were used to explore macroeconomic factor and administrative procedures. The report also emphasizes statistical details based on sales, revenue, growth rate, CAGR, profit and the structure of the manufacturer.

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Sunil is an SEO and attentive market research analyst. Expertise in leadership, public speaking, marketing, SEO, and teamwork. Skilled in performing competitive analysis to stay ahead of the others in the market. He always tries to establish and revamp existing business strategies and produce worthwhile lessons from each project.

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Global Thyroid Hormone Disorder Drug Market Research and Forecast, 2019-2024 - News Coed

Brain research has shown how relevant sleep is to health, so it's more important than ever to get a good night's sleep. In the bedroom, that means not just decorating in calming colors but also minimizing stressors and optimizing conditions for a restful night. We asked some experts for advice and products to achieve that.

Minimize noise

A key obstacle to uninterrupted sleep is noise. To reduce it, Brooklyn-based architect and designer Adam Meshberg, founder of Meshberg Group, recommends soundproofing the walls building an additional thin wall in front of the original, adding a layer of QuietRock sheetrock, or sealing any cracks or gaps within the walls. To a lesser extent, wallcoverings can also absorb sound, he says, though a padded wallcovering will do more than a simple wallpaper.

Cracks and gaps are also a problem when it comes to windows. Restoring or replacing drafty windows won't just improve your heating and cooling bills; doing so can make a huge difference in the amount of noise seeping in. If renovation isn't an option, some companies will install a thin window behind your existing window for extra soundproofing. CitiQuiet in New York says it can eliminate 95 percent of street noise.

For a simpler fix, getting an upholstered headboard (or a bed that comes with one) helps with acoustics, says Florida-based designer Adriana Hoyos. Go for fabrics at least one millimeter thick; suede, velvet, leather and leatherette are stylish options for absorbing excess noise.

Andrew Bowen, director of staging at ASH NYC, suggests a combination of loose items a large area rug (he likes the Rug Company's Deep Pile Merino Natural Rug, $137 per square foot), floor-to-ceiling window drapery and a fully upholstered bed (he recommends Cisco Brothers' April Modern Classic White Linen Slipcovered Bed, $2,375-$3,000 at Kathy Kuo Home) for a quiet, relaxing environment.

Alternatively, try white noise. A fan might do the trick, but Julien Baeza, assistant project manager at Four Seasons Hotel Los Angeles, suggests Spotify and soundscape machines.

Keep the lights out

Lights out is essential to bedtime. In particular, avoid exposure to the blue light from LED bulbs and electronic devices, says Pablo Castillo, sleep medicine specialist at Mayo Clinic. "The body reacts to this artificial light as if it [were] still daytime," he said in an email, "and the pineal gland will stop producing the sleep hormone melatonin, resulting in poor sleep quality."

That's why you should stay away from bright light for at least three hours before bedtime, reduce screen time, and set devices on night mode an hour or two before bed, plus use blue-light-blocking coating on screens or glasses if you "use computers and digital devices heavily," Castillo wrote.

To lightproof the bedroom, "blackout window treatments are a must," said Greg Roth, a designer at Home Front Build in Los Angeles, by email. "Installing a cornice box at the ceiling level can help prevent light from escaping upward from the windows and reflecting off the ceiling." Meshberg recommends the Shade Store and Somfy for motorized shades.

Go soft and simple

Simplify your space for sleeping only. It doesn't matter whether you live in a mansion or a studio, you can declutter for a calming effect, according to Meridith Baer, founder of staging company Meridith Baer Home.

A sleep-friendly bedroom is like a "good snuggle" one that makes you "feel embraced and safe," like a cocoon, Alex P. White, a furniture designer and decorator based in New York and Los Angeles, said in an email. So keep things "tonal and tactile with as many luxurious materials as your budget allows."

As for decor, keep things light and uncomplicated, says New York designer Ryan Korban. He recommends using light-colored paints that are warm and not stark (he likes Lily White from Benjamin Moore) and light-wood floors.

For the most soothing tone, Leatrice Eiseman, executive director of the Pantone Color Institute, recommends sky blue, writing in an email that it's a "positive color" with a sense of "dependability" that can help you fall asleep. You can create a "blue sky" by painting the ceiling, Eiseman suggests. Make it high-gloss for more definition.

Regulate your schedule

Not everyone needs eight hours of sleep, but to "avoid chaos in your circadian rhythms, it is suggested that you maintain the same schedule every day," says Rachel Salas, sleep specialist and associate professor of neurology at Johns Hopkins Medicine.

"Lights in the bedroom should be dimmable or have the ability to adjust to a low setting," Meshberg says. They can help your brain transition to slumber mode. Go for bedside sconces or lamps (he likes the Pennant Wall Lamp by Andrew Neyer, $200-$300 at Y Lighting, and the Convessi Sconce, $495 at Restoration Hardware).

For frequent travelers and those working night shifts, a circadian lighting system, which adjusts from a warm color spectrum to a cooler spectrum and back to mimic natural light cycles, can be especially useful. Such systems can "artificially create an ambiance that minimizes jet lag and allows for deep sleep," Baeza wrote in an email. "Some sophisticated LED systems allow for automatic dimming and color changes over time."

The brand Ketra sells lighting fixtures, bulbs and controls that can create such natural lighting and integrate with home automation systems.

Focus on the bed

No doubt, the most important component is the bed. That's why selecting the right mattress, sheets and pillows can help you get a good slumber. Meshberg recommends 200- to 300-thread-count organic cotton sheets such as the Classic Starter Sheet Set (starting at $93, Brooklinen) and the Italian Vintage-Washed 464 Percale Sheet Set ($369-$429, Restoration Hardware). They "breathe well" and don't get "too satiny and shiny" like sheets with higher thread counts.

Also, "the quality and proper weight of your duvet and down comforter are essential in regulating your temperature," Meshberg wrote. Generally, 700-fill comforters are best for winter and 600-fill works well during summer. (Fill refers to down; synthetics might be labeled as heavyweight or lightweight.) He recommends the down comforters from Brooklinen ($199-$299) and the Organic Italian Vintage-Washed 464 Percale Duvet ($389-$449) from Restoration Hardware. (The National Sleep Foundation also recommends setting your thermostat at 60 to 67 degrees.)

For a mattress, he suggests Casper's Original ($595-$1,195) or Wave ($1,345-$2,495) for those who prefer more support. The Beautyrest Recharge Dawson 12-inch hybrid firm mattress ($1,299-$1,999, mattressfirm.com) works well for those sharing beds with restless sleepers because the memory foam won't move around as much, Meshberg says.

As for pillows, "synthetic is the best" because you can wash it, he says.

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Cant sleep? You probably need to make these changes. - The Providence Journal

The menopause used to be ominously referred to as the change an entire life stage relegated to a euphemism. And, although it directly affects half the population, it has remained a stubbornly taboo topic.

Now the shroud of secrecy has finally started to lift. High-profile women are discussing their experiences or even just acknowledging them. Accepting an award on a freezing night in New York, Emma Thompson joked in her acceptance speech: Its such a cold night and its the only time Ive actively been grateful for menopause.

In the past year, parliament has set aside time to debate NHS menopause services and menopause in the workplace for the first time. Menopause cafes have sprung up around the country and Menopause: The Musical has embarked on a nationwide tour.

At the Guardian, we wanted to help drive this change forward. Our editor-in-chief, Katharine Viner, said: The menopause affects half the population, but its a largely neglected issue, both in the media and when it comes to scientific research. We wanted to interrogate the menopause in more depth, give voice to those who have experienced it and explore suggestions for how to make it more manageable for women, in the workplace and beyond.

We assembled a small team of reporters from our health, science and investigations desks. We also wanted to hear from readers, and asked them to get in touch to share their experiences. Responses came in thick and fast several hundred in total.

Many women told us that they felt there wasnt enough information or discussion about the menopause and welcomed the Guardians reporting on it, said Caroline Bannock, the Guardians communities editor.

Women said that the lack of discussion about the menopause meant that they had been unprepared for the experience. Some initially struggled to figure out what was causing their symptoms until a doctor or family member suggested an explanation that should have been obvious.

I consider myself a woman of the world and I didnt know what being perimenopausal was, Meg Mathews, the former music PR, told us. Since experiencing the menopause, Mathews has become a prominent campaigner on the subject.

There was also frustration about the apparently contradictory advice from experts on hormone replacement therapy (HRT). Gynaecologists have tended to highlight the benefits of HRT, while cancer epidemiologists have pointed to the increased risk of breast cancer. Women have been left trying to figure out how to balance the risks and benefits in their own lives.

Many women who got in touch described a wider range of symptoms besides the typical hot flushes that the menopause brings, such as mood swings, depression, brain fog and forgetfulness. But there seemed to be a lack of clear evidence or advice about how these symptoms should be managed.

There were also positive stories and ones that defied menopausal stereotypes: one woman experienced a sudden libido boost (I like to think it was my bodys last hurrah) and embarked on an affair, and another described the post-menopausal zest she felt on the other side. Another described how a GP had made her cry with his kindness, saying I was never dismissed or belittled, a reminder of how much just being listened to can make a difference.

Sarah Boseley and Hilary Osborne covered an ongoing campaign by MPs for workplace policies to protect women going through the menopause: some argue that legislation is needed to bring about reform in this area. The report also revealed the toll that the menopause can take in the workplace, according to a recent survey in which 94% of those attending a menopause clinic said they felt their work had suffered as a result of their symptoms.

The Labour MP Carolyn Harris argued that the menopause should be put on a footing with the kinds of extra support women get during pregnancy: I firmly believe there should be legislation to make sure every workplace has a menopause policy, just like they have a maternity policy.

It became clear that NHS treatment and advice was patchy across the country, with women in some areas getting access to specialist clinics and others simply being recommended HRT. During our reporting, it emerged that even HRT supplies were running out, leaving thousands of women without treatment.

Amelia Hill revealed concerns about some bioidentical HRT products, marketed as being more natural, which experts say are unsafe, expensive and could increase the risk of developing cancer. These drugs are unregulated but widely available, with some women buying products through online pharmacies.

While researching the biology of the menopause, it became clear that the neglect of the subject has extended into the types of research being funded. So much of the basic biology of the menopause is yet to be understood. It is not yet possible to predict when it will occur and who will have symptoms and who wont. Even the role of HRT whether it delays or masks the menopause has not been clearly resolved. Progress is being made, though, with the prospect of a new class of drugs on the horizon and trials showing the benefits of cognitive behavioural therapy and exercise to help manage hot flushes.

The response to our coverage has been overwhelmingly positive and reinforced our belief that there are important stories about the menopause that we should continue to pursue. Younger women want to know what to expect. Women going through the menopause want to know the evidence on treatment and to get the right support in the workplace. Breaking the taboos around the menopause is the only way to ensure that society supports women through this life milestone rather than leaving them to deal with it alone.

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Breaking the menopause taboo: 'There are vital stories we should continue to pursue' - The Guardian

Editors note: This is part two of a four-part Longevity Project: Thriving at Altitude series that will publish on Mondays through Sept. 30. The series also includes profiles on Routt County locals who are thriving at altitude.

STEAMBOAT SPRINGS People living at higher altitudes tend to be healthier, but definitive evidence as to why remains elusive.

There is debatable data, and some contradictory studies, as well as the persistent prospect that, especially in a place like Colorado, a lot of it has to do with selection: healthier people with healthier habits choose to live at higher locations.

Theres also somewhat of a survival of the fittest aspect, noted Dr. WillBaker, a cardiologist with UCHealth Heart and Vascular Clinics in Steamboat Springs and Craig.

Some thrive in a more challenging climate and geography with less oxygen, and some dont.

It also very much depends on the individual, of course.

People with underlying health issues, especially related to the lungs and heart, may find their conditions exacerbated by the altitude.

In general, said Baker, people with chronic lung problems, especially Chronic Obstructive Pulmonary Disease(COPD), will have a harder time living at altitude. The same goes for some heart conditions.

However, there is also research showing altitude having potential protective effects on the heart.

In a 2014 National Center for Biotechnology Information study titled Effects of Living at Higher Altitudes on Mortality, author Martin Burtscher wrote, The available data indicate that residency at higher altitudes are associated with lower mortality from cardiovascular diseases, stroke and certain types of cancer. In contrast, mortality from COPD and, probably also, from lower respiratory tract infections is rather elevated. It may be argued that moderate altitudes are more protective than high or even very high altitudes. Whereas living at higher elevations may frequently protect from development of diseases, it could adversely affect mortality when diseases progress.

In studies spanning the globe, researchers have seen several consistencies in people living at higher elevations: they weigh less, have less cardiovascular disease and some types of cancer and live longer.

But it isnt so straightforward to say that if you come to or are born at a higher altitude, you will lose weight, be healthier and live longer, noted Baker.

Its a lot more complex and so is the available research.

For example, while increased exposure to ultraviolet rays may increase the risk of skin cancer, the increased levels of Vitamin D intake may also have protective effects that profoundly influence cardiovascular mortality, according to Burtscher.

Some studies show people with asthma do better at higher altitudes. Some show they do worse.

And in terms of what Burtscher described as moderate versus high or very high, 6,000 to 7,000 feet can treat a body differently than 9,000 to 10,000 feet.

High altitude to a physiologist starts around 5,000 feet, altitude where the body senses changesin the oxygen level and starts to respond by increasing breathing, according to the Institute for Altitude Medicine in Telluride.

There is a reason the U.S. Olympic & Paralympic Training Center is located in Colorado Springs, noted Dr. BrentPeters, a pulmonologist at UCHealth Pulmonology Clinics in Steamboat Springs and Loveland.

Its 6,035-foot elevation is a sweet spot that provides the most conditioning benefit in terms of ideal oxygen deprivation.

The relationship between lower body weights and altitude comes with several hypothesis.

A 2013 study in the International Journal of Obesityfound a strong association between altitude and obesity in the United States. Using data from more than 400,000 people, researchers foundpeople living closest to sea level were four to five times more likely to be obese, compared to people living significantly above sea level in Colorado.

One possibility is simply that people exercise more though the study did control for that factor and still saw people losing weight.

One theory has to do with eating fewer calories altitude has been shown to increase levels of leptin, a protein hormone that plays a role in appetite control and metabolism. Hypoxia (lack of oxygen) also is known to cause a loss of appetite.

In terms of how a body living at altitude varies from one living at sea level, the primary thing that happens in terms of physiology, said Baker, is that the blood compensates with a higher amount of hemoglobin, which increases the amount of oxygen that can be carried.

One thing Baker does see on a regular basis is more severe impacts from sleep apnea.

Sleep apnea is defined by the Mayo Clinic as a potentially serioussleepdisorder in which breathing repeatedly stops and starts.

Peters, who travels around the state providing care, said he also sees an acceleration or exaggeration of sleep apnea in patients.

They basically dont breathe well at night, Baker said. They wake up frequently and feel fatigued the next day. Often those people sleep better and feel more energetic at sea level.

Theres also a wide spectrum of sleep apnea and different kinds, Peters noted. Most sleep apnea cases are classified as obstructive, in which a person cant breathe normally because of an upper airway obstruction, occurring when throat muscles relax.

Central sleep apnea, which is less common, occurs when your brain doesnt send proper signals to the muscles that control breathing, according to the Mayo Clinic.

Peters said he sees more central sleep apnea in Colorado than other places.

According to a Medlink Neurology report, Central sleep apnea due to high-altitude periodic breathing affects about a quarter of people who ascend to 2,500 meters (8,202 feet) and almost 100% of those who ascend to 4,000 meters (13,123 feet) or higher.

Kids can also experience difficulty sleeping at higher altitudes, said Dr. Steven Ross of Sleeping Bear Pediatrics.

Before they can verbalize how they feel, very young children may seem restless at night and irritable during the day, he said, especially above 7,500 feet.

If a normally energetic kid sits down and whines on the Uranium Mine Trail while hiking or at the top of a ski run, theres a good chance they are experiencing effects of altitude, Ross said, and arent just spoiled and lazy.

And that goes for kids who live here as well as visitors, he said.

When recreating at higher altitudes, Ross advises parents to make sure kids are hydrated and well protected from the sun. Make sure they get good sleep, and factor in patience, he said. Be aware that kids may not have the same endurance they do at lower elevations.

Altitude does play a significant role as babies develop in utero, described Allyson Daugherty, a neonatal nurse practitioner with Childrens Hospital Colorado who cares for newborns in the special care nursery at UCHealth Birth Center in Steamboat Springs.

Babies born at higher altitudes (especially over 8,000 feet) are typically smaller in size.

Altitude contributes to overall growth from a weight perspective, she said.

And, for those tiny developing lungs, mothers making it to the 36-week mark is imperative, she said.

Lungs continue to develop until two to five years of age, Daugherty said, but those last few weeks in utero is crucial, and the primary reason doctors want to see mothers, particularly at higher altitudes, make it to term (40 weeks). The more premature a baby is, the more susceptible the baby is to respiratory distress.

Babies can become hypoxic, she said, and frequently need a little more oxygen during those first few months of life as their lungs mature especially if they are born prematurely.

A lot of babies born at UCHealth Yampa Valley Medical Center are given supplemental oxygen, Daugherty said, as are babies who are born in Denver and travel to Steamboat or are going home to elevations higher than Steamboat.

Even babies who make it to 36 weeks may need some support to continue their lung development after they are born. But those lungs can, and usually do, mature fully after birth without any lasting detrimental effects.

A huge portion of babies (born at YVMC) go home with oxygen whether they are pre-term or term, she said.

The American Academy of Pediatrics recommends parents sleep in the same room as their babies at least up to 6 months of age, Ross said, something even more important at high altitude. The optimal recommendation is sleeping in the same room through 12 months of age.

The good news is, said both Peters and Baker, most people young and old adapt quite well and relatively quickly.

Peters noted that many of his patients are snowbirds, and he asks them to take note of any differences in how they feel living at the different elevations.

Both doctors say it is rare they will tell a patient they should move to a lower elevation.

Only in the most extreme cases, Baker said, will he tell a patient they should move when, even with supplemental oxygen and other medical interventions, in the face of significant lung or heart disease, We just cant keep them in a safe zone.

Of course, many people who do live at altitude, especially as they age, use supplemental oxygen.

Supplemental oxygen, as well as medication, can help people with pulmonary hypertension (high blood pressure of blood vessels in the lungs), which can worsen at higher elevations.

Aside from those rare cases, some people make their own decision if they find they feel more energetic and are able to be more active at sea level, Peters said.

Theres also the eternal importance of maintaining a general level of fitness. Baker thinks this may have more to do with people living longer at high altitudes than anything else.

Its not cut and dry, emphasized Peters. For people, especially as they get older, altitude may stress the lungs, but the low humidity and clean air can also make it easier to breathe. Some people may feel better higher up, some worse.

In a review recently published in USA Today examining 2014 county-level life-expectancy data, Routt County ranked 30th among the top 50 counties across the nation. Cities were not included.

The top three spots for the counties with the highest life expectancy went to Summit (1), Pitkin (2) and Eagle (3).

Given the longevity of those high-up counties as the very highest in the nation, it does add interesting fodder to the question: Is it the type of people living there and their lifestyle, or is there something else in the air?

And there is a growing body of research examining the effects of altitude on the body, seeking to better answer that question.

Still, It all points to the fact that one of the best things people can do is just stay generally fit, said Baker. Thats the best way to enjoy this environment and everything it has to offer.

To reach Kari Dequine Harden, call 970-871-4205, email kharden@SteamboatPilot.com or follow her on Twitter @kariharden.

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Thriving at altitude, part 2: How life at altitude impacts people and animals - Steamboat Pilot & Today

Vegan meat is here. And according to sales data and consumer preference, its here to stay.Food companies are discovering that plants can deliver the same sizzle, bite, and mouthwatering taste as animal-based meat, but without leaving so heavy a mark on our bodies, the planet, and the billions of animals in the food system.

While animal meat has long been viewed as a healthy way to get protein and iron, research continues to point to health hazards.

Meat typically contains high levels of saturated and trans fats, which can raise blood cholesterol. High cholesterol can lead to plaque forming along the inside of the artery walls. This causes the artery to narrow and blood flow to decrease, increasing the risk of stroke, peripheral artery disease, and heart disease. A 2018 study by the Cleveland Clinic found that eating red meat could increase the risk of heart disease 1,000 percent more than a plant-based diet.

In 2015, the World Health Organization (WHO) classified red meat as a Group 2 carcinogen, meaning it probably causes cancer in humans. WHO placed processed meat like bacon and pepperoni in the Group 1 category, which says it is carcinogenic to humans. Tobacco smoking and asbestos are also in this category.

Even small amounts of meat can have a real impact on ones health. An Oxford University study from earlier this year found that eating just three rashers of bacon a day could increase cancer risk by 20 percent.

Eating meat is also connected to the onset or worsening of diabetes, arthritis, liver disease, and kidney disease.

Animal agriculture is a leading driver of a myriad of environmental issues including water pollution, air pollution, ocean dead zones, and species loss.

Beef production was identified as a leading cause of the Amazon rainforest fires since vast swaths of forest are burned intentionally to make room for the production of beef and animal feed; agriculture accounts for 80 percent of all deforestation according to a report funded by the British and Norwegian governments.

The meat industry is also responsible for a significant percentage of all greenhouse gas emissions, which lead to climate change. Last year, Oxford University researchers conducted the most comprehensive analysis of farmings impact on the planet ever conducted. The researchers analyzed data from approximately 40,000 farms in 119 countries and concluded that going vegan is the most powerful tool in the fight against climate change. Lead researcher Joseph Poore said adopting a vegan diet is the single biggest way to reduce your impact on planet Earth, not just greenhouse gases, but global acidification, eutrophication, land use, and water use.

Plant-based meat is just what it sounds like meat made from plants. Pea protein, soy protein, wheat, and mushrooms are commonly used to create juicy meat products.

People love vegan meat the evidence is in the numbers. Data released by The Good Food Institute (GFI) and the Plant Based Foods Association (PBFA) found that vegan meat, chicken, pork, and even seafood are all quickly outpacing their animal-based counterparts.

Sales of vegan meat increased by 37 percent in the past year while sales of animal-based meat only grew by 2 percent. The plant-based meat category is now worth more than $800 million and this figure is climbing. A 67-page report released in July by UBS Group AG, a multinational investment bank and financial services company, said that the plant-based protein market could be valued at $85 billion by 2030.

Unlike animal meat, plant-based meat contains no cholesterol. Dietary cholesterol is only found in animal-based foods, meaning that veganism is the only truly cholesterol-free diet, according to Medical News Today.

Vegan meat is a good source of protein. The plant-based Beyond Burger, for example, boasts 20 grams of protein per serving, which is more than a third of the average recommended daily protein intake. The plant-based Impossible Burger offers 19 grams of protein.

Vegan meat is also rich in fiber. Compare that to animal meat, which contains zero grams of fiber and plant-based protein becomes even more appealing. Earlier this year, University of Otago researchers discovered a connection between a fiber-rich diet and the reduced risk of multiple diseases. Data from 185 observational studies found that those who consume the most fiber are 15 to 30 percent less likely to die prematurely. Eating fiber-rich foods was also linked to a 16 to 24 percent reduced incidence of type 2 diabetes, stroke, and colon cancer.

A Harvard study, which included more than 40,000 healthy men, found that a diet rich in fiber may reduce the risk of coronary heart disease by 40 percent.

Health, the environment, and ethics are seeing more people swap their meat for plants. Major British supermarket Sainsburys released data earlier this year showing that 91 percent of Brits are now flexitarian people who eat animal products but focus on including more plant-based food in their diet.

Another recent survey found that 80 percent of Americans want to replace meat with vegan food. A poll by Angus Reid found that 70 percent of Canadians believe vegan meat is not a passing fad but a movement that is here to stay, and a recent report predicts that the popularity of plant-based meat will boost Australias economy by $3 billion by 2030.These seven meat brands are instrumental in the meat-free movement, helping the masses eat more sustainably and more healthily, but without compromising on taste.

For more than 40 years, Lightlife has been making Food That Shines better-tasting, easy-to-prepare, plant-powered protein.

Lightlifes juicy vegan quarter-pound patty contains 20 grams of protein, 0 grams of cholesterol, and only 2.5 grams of saturated fat, compared to the 80 grams of cholesterol and 9.3 grams of saturated fat in a conventional beef patty.

Lightlifes food is for everyone, not just vegans. As well as the Lightlife Burger, the company produces plant-based chicken, ham slices, and bacon. Lightlifes Smart Dogs are a summertime classic, bringing all the juicy goodness to outdoor barbeques. Earlier this year, the company launched vegan sausages in two meaty flavors Bratwurst and Italian. Both deliver the taste and texture of traditional pork sausages.

Lightlife was a pioneer of the non-GMO movement. The food brand publicly announced in 1999 that all of its products would be free from genetically modified organisms a full eight years before the Non-GMO Project was founded.

Its this forward-thinking attitude that has helped the brand become a favorite across the U.S. The Massachusetts-based brand was credited for helping its parent company Maple Leaf Foods reach $1.02 billion in revenue, up from $9.09.2 million last year. Maple Leaf will soon open a 30,000-square-foot facility which will be used to produce products by Lightlife and Maple Leafs other acquisition Field Roast. The new facility will allow both brands to more than double production capacity. Maple Leaf expects Lightlifes vegan burger will soon be more widely available than the Beyond Burger.

You can find Lightlifes vegan products in the meat aisle at Sprouts, Wegmans, and Foodtown in the U.S; at Sobeys, Walmart, and Metro in Canada; or at a restaurant near you. You can also check the websites store locator.

Field Roast believes food tastes better when its crafted with care. The company stands by the concept that real food is best. So it starts with familiar, high-quality, whole ingredients such as grains, fresh-cut vegetables, herbs, and legumes. Field Roasts artisans then use time-honored charcuterie techniques to carefully craft great-tasting, better-for-you vegan meat.

The company pays homage to regionally beloved spices and ingredients by uniting bold flavors to deliver a complex, layered taste experience.

Field Roast offers products to suit all occasions and meals. Its Apple Maple Breakfast Sausages are perfect for morning meals. Deli slices are ideal for school lunches. Mini Corn Dogs spruce up any social event. And the Celebration Roast is a must for the holidays. For grilling, nothing beats Field Roasts FieldBurger, which is made from barley, carrots, garlic, and onion. The juicy plant-based burger has been winning over sports fans across the country since it was added to stadium menus in 2012.

The companys four sausage varieties are also must-tries, including its new bratwurst which features Elysian Brewing beer from Field Roasts home city, Seattle.

You can find Field Roasts products at Sprouts, Walmart, Whole Foods, Acme Markets, and Safeway in the U.S. and at Sobeys, Metro, and Walmart in Canada. Check out where to find them here.

Naturli is shaking up the food industry with its innovative plant-based meats. Since 1988, the Danish company has challenged the belief that meat and dairy must come from animals. Using ingredients like almonds, coconuts, rice, oats, and soy, Naturli makes cruelty-free, planet-happy food.

Naturli Minced is perfect for an authentic bolognese or a mouthwatering homemade burger. The fresh vegan mince, which can be fried straight from the packet, offers flavors of tomato, porcini mushrooms, and almonds. Its made with peas, which are full of protein and fiber and contain vitamin C and B complex vitamins.

The vegan meat is also better for the planet than its animal-based counterpart; it requires vastly less water and land to produce than beef mince. A comprehensive food analysis by Oxford University researchers found that land use would drop by 75 percent if people replaced beef with plant-based options.

Even the Naturli Minced packaging strives for sustainability the plastic tray that Naturli Minced comes in is made of 80 percent recycled plastic.

The companys Chick Free is the vegan chicken product youve been waiting for. Chick Free, also made from high-quality peas produced in Denmark, is great for curry, wraps, salads, or wherever your imagination and taste buds take you. The packaging for the product is made of at least 50 percent reusable plastic.

You can find Naturlis vegan products in the meat aisle at Sainsburys in the UK, Coles in Australia, Albert Heijn in the Netherlands, and Frs in Sweden. More info here.

Moving Mountains wants to help build a better world. The plant-based meat brand was founded by a vegan environmentalist, Simeon Van der Molen. Simeon wanted to bring amazing plant-based meat to the UK food that had the taste, look, smell, and chew of animal-based meat but contained no animal products. Moving Mountains brings together food technology, incredible scientific processes, specialized machines, and local natural ingredients to make its plant-based hot dog. And the result is unlike any other on the market.

The company uses ingredients including carrot, onion, coconut oil, and sunflower seeds to make the hot dogs. Sunflower seeds are rich in B complex vitamins and offer 6 grams of protein per serving. Coconut oil contains antioxidants and medium-chain fatty acids (MCFAs) which are easily absorbed and metabolized, providing a boost of energy.

But the hot dog doesnt taste like plants. It offers a naturally smoked flavor and tastes so much like pork youll be double-checking the packet.

The company also makes burgers that are hormone-free, cholesterol-free, and antibiotic-free but theyre certainly not taste-free. The protein-packed burger bleeds, cooks, and browns like a conventional beef burger. It even contains 100 percent of your RDA of B12.

You can find Moving Mountains plant-based meats at thousands of locations throughout Europe including Hard Rock Cafe, Applebees, and universities. Moving Mountains will soon be launching globally. Use the store locator here.

The worlds largest food company, Nestl, is tapping into the burgeoning vegan market via its Sweet Earth brand. Sweet Earth is set to launch the Awesome Burger later this year. The plant-based burger is made from yellow pea protein and wheat but boasts the juiciness and taste of beef.

The Awesome Burger offers six grams of fiber per patty and has more protein than a meat burger 28 grams versus a typical 20 grams. The plant-based meat is a good source of iron and vitamin C and has no saturated fat or cholesterol.

Sweet Earths vegan Awesome Burger will hit supermarkets and restaurants in fall. Find the store locator here.

For truly epic veggie eating, look no further than Oumph!. This plant-powered meat brand is on a mission to create great-tasting food thats so good for the planet, you can eat it every day.

Oumph! uses ingredients like beans, apple juice, garlic, tomato, onion, and soy protein to create its super meaty products. Its Pulled Oumph! is perfect for tacos, the Oumph! burger is begging to be grilled, and the companys vegan kebab meat featuring paprika, coriander, ginger, cumin, and parsley can be added to casseroles.

You can find Oumph!s vegan meat at Tesco, Lidl, ASDA, and Whole Foods. Get more info here.

Food company Don Lee Farms might have started out making meat, but now the company says its plant-based patties are better than the real thing.

Don Lees new Better Than Beef Burger which, according to the company, is better on the grill, better for the planet is made with non-GMO ingredients. The thick and juicy quarter-pounder is free from gluten and cholesterol. It joins Don Lees other vegan meat options, like its organic, ready-to-grill Plant-Based Burger. The patty offers 15 grams of protein and contains no artificial ingredients. The vegan burger has proved popular among shoppers; when it first launched at Costco in the U.S., it was purchased one million times in 60 days.

You can find Don Lee Farms vegan meat products at Costco, Kroger, and Ralphs. More info here.

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These 7 Brands Are Making Ridiculously Meaty Vegan Meat

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These vegan meats could help sidestep the health, environmental, and ethical downfalls of animal meat. These brands make the best vegan meat out there.

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Jemima Webber

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These 7 Brands Are Making Ridiculously Meaty Vegan Meat - LIVEKINDLY

Pregnancy pressure might take a toll on a womans mental health. Ovulation predictor kits are offering an easier option to people who have difficulty in conceiving, discovers Ayushi Sharma

Battling infertility, you thought that all roads lead to IVF or surrogacy? But things do not have to always end up at an intensive treatment route. For there are ways to do this in a natural way. The advancement in medical technology means that a clinical device can help you identify and track your fertile window in the comfort of your home.

The need for these arose as the attempt to conceive can be stressful due to rising societal pressure, a ticking biological clock, which, in turn, often leads to repeated clinic visits, blood-drawing and ultrasounds things, which are not just time-consuming but also expensive.

According to State of World Population Report 2019, the fertility rate per woman was 5.6 in 1969, it dropped to 3.7 in 1994, and is 2.3 in 2019. The changed statistics can be attributed to a variety of reasons, which include lifestyle and behavioural changes. With almost one in six couples facing problems in conceiving and one in two couples tracking their cycles incorrectly, there is a need for proactive measures. With changing lifestyles and associated issues, getting pregnant is not as easy as it used to be which in turn has led to the dip in fertility rates considerably.

These devices are doing away with overwhelming trips to clinics for invasive tests that make you feel like you have a huge fertility problem, even when you dont. Fertility monitors can act as personal assistants that help you understand your body and hormones better. While most women believe that their chances of getting pregnant are highest on the 14th day of their cycle, the truth is that ovulation varies from woman to woman and cycle to cycle. Whats more, fertility monitors can help in case of issues like irregular cycles, PCOS, PCOD, thyroid as well, thereby helping you take total control of your fertility, proactively. Taking the guesswork out of the process of conception, it measures estrogen and luteinising hormone levels in your urine to detect peak fertile days in your menstrual cycle.

The best time to conceive is right before a person ovulates or releases an egg because the internal body temperature fluctuates during the menstrual cycle. But it is possible to get pregnant in the days leading up to ovulation, as sperm can survive for several days inside the female body, says Dr Neena Bahl, director, obstetrics and gynaecology, Fortis LaFemme, Greater Kailash II. She adds that testing through fertility monitors is just like doing the pregnancy test. An ovulation kit tests your urine sample to detect a surge in LH (luteinising hormone) levels. While the LH is always present in your urine, it increases 3436 hours before ovulation, which is five times the regular mount. These tests help you find out those days that act as an invaluable tool in your baby-making arsenal. This time is your most fertile window. Having intercourse on those particular days increases your chance of a successful conception.

There are various ways in which one can track fertility. Some ways are as simple as tracking your temperature in the morning as the day your fertile period starts, the temperature goes up by half a degree. Second, to get an ultrasound on any of the 10 days from the ninth day of your period to 19th day, which shows the exact size of the follicle or the egg and once it ruptures, it is the most fertile period to conceive. Third, there are commercially available sticks that tell about the changes in the hormones. Its an indirect way of letting one know that ovulation is going to take place, explains Dr Bahl and tells us that in most cases, ovulation predictor kits provide an accurate forecast of your LH surge and subsequent ovulation. They can be most effective when used together with other monitoring methods. Along with the kits, doctors usually suggest examining the cervical mucus and charting the basal body temperature which is tested the first thing in the morning. These methods, when combined, can greatly increase your chances of getting pregnant.

As there are advantages and disadvantages of everything, Dr Bahl says, The pros are that it is a simpler way of knowing the best possible chance of conceiving. Instead of going to the doctor and getting an ultrasound done, you can choose this method but the con is that it is not as sensitive as the latter. Everytime you are testing yourself, your mind is preoccupied and its obvious when you are trying too hard for something, you get stressed. You do not release happy hormones which in turn affects your ability to conceive. Moreover, your sexual life is timed according to the device and becomes mechanical. It becomes something solely devoted to reproduction. So yes, it can be a rough method but then its obviously a convenient option.

One of the users of the ovulation predictor kits shares her experience. Shweta Verma, 32, a software engineer from Bengaluru, says that they started their family planning after two years of marriage. She was, later in the same year, diagnosed with PCOD and was prescribed a medication for six months. After which, they were advised by the doctors to try conception naturally. The doctor recommended the use of the monitor to ease the journey. I used it for three cycles after which it was discovered that my husband had a low sperm count. I continued using it and even crosschecked the results with ultrasound scans. They turned out to be identical. This strengthened my faith and I finally got the good news, she says and adds that the monitor eases the journey of a woman.

However, these kits do have limitations as they do not work when fertility drugs are present in the system. Moreover, they do not work consistently on women over 40. Some women in their 40s, especially those approaching menopause, have increased levels of LH in their systems at all times, rendering the tests invalid.

But coming to surrogacy or for that matter IVF, these are for people who are infertile or have medical conditions which do not allow them to conceive naturally. Alisha Mathur, 36, a housewife, feels that the device helps women conceive but I dont think it can ever replace doctors or labs or even procedures like surrogacy. It works even for irregular cycles and notifies when there is a probability of a fertility condition or issue which requires clinical support. Surrogacy is a different thing altogether. In the rarest of the rare cases, doctors suggest it.

Dr Bahl explains it better when she says, You cant jump from class one to class 10. Similarly nobody jumps from tracking ovulation to surrogacy. What would a normal healthy couple do? They would try conceiving without any contraception for one year. And 90 per cent of the couples will conceive within one year of married life. So when you dont, you start tracking the fertility manually. But most of the times you would visit a doctor and ask for his/her help. The doctor will then guide the couple about the various methods. Only when they have tried everything and failed does the doctor advise surrogacy. It might be a marketing gimmick that you can avoid surrogacy if you buy this device. However, the trackers just help women conceive quickly.

Using the ovulation predictor kits or so-called fertility monitors provides more privacy as issues like fertility are things that women dont prefer to discuss in public, feel both the users of Inito fertility monitor.

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Time the stork's visit - Daily Pioneer

I suffer from adult acne and its important to break down the myths and talk about the causes, says guest editor Billie Piper. Stylist reveals five misconceptions about the common condition

Synonymous with train-track braces and heavy side fringes, you might think you left acne behind in your teenage years. But for many, that isnt the case. Adult acne a skin condition that occurs when hair follicles become plugged with oil and dead skin cells is on the rise. So while most of us have experienced acne at some point, 15% of women are diagnosed as adults. As a result, Cult Beauty has seen a 66% increase in sales within its acne product category.

Refreshingly, the rise in adult acne is being chased by a growing skin positivity movement. Needless to say, blemishes are a completely normal facet of life and a growing number of us have taken to Instagram to share #skinpositivity posts, chipping away at any shameful stigma that was once attached to the condition. Themovement also celebrates skin acceptance the idea that if youre happy with your acne, thats great, but its also OK if you want to take steps to reduce it.

This weeks guest editor Billie Piper frequently speaks candidly about her experiences with adult acne, and is currently undergoing treatment from renowned skincare expert and go-to celebrity facialist Debbie Thomas at her D Thomas Clinic in London. Debbie had acne as a child, so she understands the impact it has on your skin and your mind, says Billie.

The issue is knowing where to start with acne treatment it can be a minefield, especially when you consider the numerous potential causes and the fact that everybodys skin is different. So, we spoke to Debbie Thomas and dug a little deeper into the five key things you need to know about adult acne.

Type acne into Google and the first images to pop up tend to include severe red cysts. However, acne appears in many different guises: even if you only get one or two spots a month, it might still be medically classed as mild acne.

Acne is simply the medical word for spots, says Dr Anjali Mahto, consultant dermatologist and British Skin Foundation spokesperson. Doctors refer to acne regardless of whether the problem is a small handful of spots or more extensive affecting the face, chest and back. There are six types of spots caused by acne: blackheads, whiteheads, papules, pustules, nodules and cysts. But when is a blemish not acne? These are normally allergy-related bumps which are very small and affect the very surface, says Debbie Thomas. Or theyre related to hair growth and can be irritation from shaving or actual ingrown hairs.

While diet, pollution and lifestyle are often touted as the main causes of acne, hormones particularly those triggered by womens menstrual cycles are the only scientifically proven cause. During the first half of our cycle, oestrogen is dominant and in the second half it is progesterone, says Dr Mahto. Just before menstruation, these hormones drop and our androgen hormones (a type of male hormone) are high. These act on oil-producing glands to increase their size and activity resulting in acne.

Acne could also signal an underlying medical issue. Acne can be a common sign of polycystic ovary syndrome (PCOS), Dr Mahto explains. Studies show that 19-37% of women with moderate or severe acne will meet the criteria for PCOS (having at least two of three symptoms: irregular periods, high levels of androgens or polycystic ovaries).

If acne develops after adolescence, it might be hereditary. Its hard to pinpoint one reason. That is why it is so hard to treat and get rid of permanently, says Thomas. Acne affects people differently, so treatments will vary depending on the severity from medication such as azelaic acid or isotretinoin capsules (also known as roaccutane) to treatments like microdermabrasion. If youre unsure whether a blemish is acne, seek professional advice from a GP or dermatologist.

If your acne is bothering you, it can be tempting to slather on all the super-strength acne-fighting formulas you can find, but its vital to be patient. In fact, before entering the world of skincare, Thomass own acne saw her regularly using harsh products. None of it helped and, a couple of times, I actually burned my skin, she recalls.

The best approach is to strip your skincare back to basics (cleanse and moisturise), adding active formulas in gradually. It can take using an active ingredient like retinol regularly up to nine months to show results, so dont jump from one ingredient to the next, says Thomas.

Cleanse your face twice a day. Products that contain salicylic acid and zinc may be beneficial, says Dr Mahto. After a couple of weeks, start using a chemical exfoliant (like glycolic acid) once a week. This will remove the upper layer of skin cells and help reduce blackheads.

Once your skin has acclimatised, you can introduce an active treatment. For mild acne, a pharmacist can prescribe over-the-counter creams (containing ingredients such as bacteria-killing benzoyl peroxide), but for moderate or severe acne, prescription medication might be best speak to your GP.

If you want to try a clinical treatment, book in for a consultation to ensure your skin is suited to whats on offer. We work with lasers, peels, light therapy and microneedling, alongside a good home care routine, says Thomas.

The psychological impact of acne cant be overlooked. Acne has been associated with anxiety, depression, poor quality of life, lack of self-confidence, feelings of isolation, embarrassment, low self-esteem and problems with body image, explains Dr Alia Ahmed, psychodermatologist at Eudelo Clinic.

Social media can be particularly damaging. The pressure to look perfect can affect the psyche, says Dr Ahmed. I have seen patients who cannot look at an unedited photo of themselves as they find their skin repulsive.

Try following people who encourage positive conversation around skin conditions on social media. And when seeking medical advice, discuss the impact acne is having on your life. If patients are reporting emotional problems, I encourage them to seek support throughtalking therapies and/or oral mood managing medications, if needed, recommends Dr Ahmed, who also flags online resources such as skinsupport.org.uk and changingfaces.org.uk.

Even if your acne fades, scars and pigmentation can be left behind. There is sometimes an unrealistic expectation of how skin should look after acne treatment, says Dr Ahmed. Most scar treatments are not available on the NHS and this can make people feel despondent. Its no surprise, then, that scar treatment is one of the most popular acne-related searches on Cult Beauty.

Clinical treatments differ depending on the type of scar. They are categorised according to shape, depth and colour and the NHS identifies three main types: ice pick, rolling or boxcar. Scars require different forms of treatment but Thomas tends to rely on microneedling, microdermabrasion and peels, while stronger peeling lasers are used for deeper scarring. If it is a textured scar, a certain amount of controlled damage to the skin is required to try and stimulate new collagen production to get the area to repair itself, she explains. The reality is its difficult to get scarring to go completely. Results, which typically display a 30-70% reduction, can take time, with even the strongest treatments often requiring several sessions over one or two years.

High-tech, blemish-relieving formulas that will soothe and treat your skin

Plenaires Tripler 3-in-1 Exfoliating Clay, 30, is an effective mask, cleanser and gentle once-a-week exfoliator.

Murad InvisiScar Resurfacing Treatment, 35, is a daily serum containing salicylic acid and vitamin C to reduce scarring.

Ideal for bumpy, dehydrated skin, CeraVe SA Smoothing Cleanser, 12, doesnt leave skin feeling tight.

When spots appear, apply Squish Flower Power Acne Patches, 12, overnight. The hydrocolloid helps to soothe and minimise.

Apply La Roche-Posay Effaclar Duo+, 16, morning and evening to reduce spots and pigmentation.

Wear No 7 Laboratories Clearing Paste, 18, overnight two to three times a week and wake up to clear, soothed skin.

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Acne causes, symptoms and treatments: everything you should know - Stylist Magazine

MRInsights.biz announced that its published an exclusive report namely Global Endocrine System Drug Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2024 in its research database with report summary, table of content, research methodologies and data sources. The research study offers a substantial knowledge platform for entrants and investors as well as veteran companies/manufacturers functioning in the Worldwide Endocrine System Drug Market. This is an informative study covering the market with in-depth analysis and portraying the current state of affairs in the industry.

This report studies the market with many aspects of the industry like the market size, market status, market trends, and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers. Market segmentation by companies, region, and type forms an integral part of this report. Historical data available in the report supports the market development on national, regional and international levels. This is an informative study covering the market with in-depth analysis and portraying the current state of affairs in the industry.

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Key Manufacturers Analysis:

The Global Endocrine System Drug market report offers the vendor landscape and a corresponding detailed analysis of the major vendors operating in the market. In short, competitive insights provide an expert view of leading market players and market strategies.

The top manufacturers, exporters, and retailers (if applicable) around the world are analyzed for this research report with respect to their company profile, product portfolio, capacity, price, cost, and revenue. For competitor segment, the report covers the following global Endocrine System Drug market key players and some other small players: Novo Nordisk, Sanofi, Merck, Eli Lilly, AstraZeneca, AbbVie,

For geography segment, regional supply, application-wise, and type-wise major players, demand, the price is presented from 2014 to 2024, covering: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa).

For type segment, this report focuses on the status and outlook for the product type. The key types are: Diabetes Drug, Human Growth Hormones, Thyroid Hormone Disorder Drugs, Others

For end use/application segment, this report focuses on the status and outlook for key applications. The main applications are: Hospital, Clinic, Medical Center, Others

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Moreover, the report serves the relevant facts and figures collected from the regulatory institutions and other key sources, exploring the growth of the industry for the estimated period (2019-2024). In terms of consumption, this report focuses on the consumption of Endocrine System Drug by regions and application. The research encompasses various factors about the market, its popularity in the global market, segmentation, current trends that are being followed, technological advancements, and future forecasts.

Analytical Tools:

The Global Endocrine System Drug Market Report integrates information regarding significant market members and their market scope. Porters five powers analysis, SWOT investigation, and achievability study are done in this report. Qualitative- and quantitative-wise review was also performed during the analysis.

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Global Endocrine System Drug Market 2019 Technology Advancement: Novo Nordisk, Sanofi, Merck - Premier Herald 24

Alternative cancer treatment therapies are now a days are actively involved in limiting the growth of cancer. These therapies are also known as precision medicines. Recently alternative cancer treatment have gained increasing focus in the industry as these therapies forms that uses complementary and alternative methods or techniques to prevent, and treat cancer at an earlier stage. Alternative cancer treatment market comprises of acupuncture, aromatherapy, exercise, hypnosis, massage, meditation, music therapy, relaxation techniques, yoga and other alternative therapies. Alternative treatments may not assume an immediate part in curing the tumor, yet they may enable you to adapt to signs and indications caused by various diseases. Basic signs and side effects, for example, nervousness, weakness, vomiting and pain, and stress might be decreased by these natural elective medicines. There are numerous choices one could seek after in elective growth medications and a brainy consolidated approach is regularly the best. In any case, certain elements stay clear and predictable and those are the contributing tumor factors that any treatment should completely address: informational signaling interference fields (bioenergetic blockages), unresolved traumatic emotional conflicts, excess of toxins, inadequate drainage, and failure of nutrient delivery systems.

Alternative cancer treatment market is growing, this is attributed to increasing prevalence of various types of cancers such as lung cancer, breast cancer, colorectal cancer, prostate cancer, lymphoma, leukaemia, melanoma etc. Also increasing awareness regarding natural alternative and complementary therapies such as acupuncture and chiropractic therapy is expected to drive the market over the forecast period. Growing healthcare expenditure, and rising insurance coverage, aids in the revenue growth of alternative cancer treatment market. Top alternative cancer treatment include IPT insulin potentiation therapy, iscador aka mistletoe extracts, Gerson Therapy, Ukrain, biomagnetic therapy, biotherapeutic detoxification & drainage and others. However, less efficacy and impact of these alternative along with less coverage to cure the cancer is expected to hamper the growth of the alternative cancer treatment market over the forecast period. Individuals have started ensuing an all-natural plan and method that included vegetable juicing, probiotic foods, organic, plant-based foods, raw juices, natural and immune-boosting supplements. Other complementary methods include proteolytic enzyme therapy, budwig diet, vitamin c chelation, frankincense essential oil therapy, sunshine and vitamin D3, oxygen therapy and hyperbaric chambers, and others.

The Alternative cancer treatment market is segment based on the therapy type, end user and application

Alternative cancer treatment market is segmented into following types:

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By Therapy Type Hormone Therapies Acupuncture and Dietary Supplements Others

By Disease Indication Gastrointestinal Lung Cancer Breast Cancer Colorectal Cancer Leukemia Lymphoma Melanoma Prostate Cancer Others

By End User Hospitals and Clinics Cancer and Radiation Therapy Centers Home Care Others

Alternative cancer treatment market revenue is expected to grow at a significant rate, over the forecast period. The market is anticipated to perform well in the near future due to increasing awareness regarding various cancer types and their treatment protocols. Also the alternative cancer treatment market is expected to expand globally due increasing prevalence of cancer and increasing preference of healthcare professionals to prescribe supplements for the patients. The natural and supplemented therapies for lung cancer is anticipated to grow with a fastest CAGR over the forecast period, attributed to increasing number of smokers globally. Increasing competition among drug manufacturers, increasing investment in R&D and increasing number of new alternative therapies and dietary supplements are the major factors estimated to drive the revenue growth of alternative cancer treatment market.

Depending on geographic region, the alternative cancer treatment market is segmented into five key regions: North America, Latin America, Europe, Asia Pacific (APAC) and Middle East & Africa (MEA).

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North America is occupying the largest regional market share in the global alternative cancer treatment market owing to the presence of more number of market players, high patient awareness levels, increasing awareness about complementary therapies and marketing activities in the region. Asia Pacific is expected to grow at the fastest CAGR because of increasing prevalence of different types of cancers in the region, thus boosting the market growth of alternative cancer treatment market throughout the forecast period.

Key players of alternative cancer treatment market includes Innovative Medicine, LLC, Esperity, Northwest Natural Health Clinic, and many more. The companies in alternative cancer treatment market are increasingly engaged in strategic partnerships, collaborations, mergers and acquisitions to capture a greater pie of market share as the market is in the nascent stage.

The research report presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, and statistically supported and industry-validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report provides analysis and information according to categories such as market segments, geographies, types, technology and applications.

The report covers exhaustive analysis on: Market Segments Market Dynamics Market Size Supply & Demand Current Trends/Issues/Challenges Competition & Companies involved Technology Value Chain

Regional analysis includes North America (U.S., Canada) Latin America (Argentina, Mexico, Brazil, Rest of Latin America) Europe (Germany, Italy, France, U.K., Spain, Russia, Rest of Europe) Asia Pacific (China, India, Japan, Rest of APAC) Middle East and Africa (Rest of MEA, S. Africa)

The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

Report Highlights: Detailed overview of parent market Changing market dynamics in the industry In-depth market segmentation Historical, current and projected market size in terms of volume and value Recent industry trends and developments Competitive landscape Strategies of key players and products offered Potential and niche segments, geographical regions exhibiting promising growth A neutral perspective on market performance Must-have information for market players to sustain and enhance their market footprint.

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Alternative Cancer Treatment Market Poised to Expand at a Robust Pace Over 2018 2026 - Wolf Mirror

Cultured meat also called lab-grown, cell-based, and clean meat could be on dinner tables sooner than once thought. The futuristic cellular agriculture industry is only becoming busier and some say lab meat could be available as soon as 2021.

Lab-grown meat is produced by in vitro cultivation of animal cells. Cellular agriculturists collect a small sample of cells from an animal. These can come from swabbing skin tissue, a feather, etc. The cells must have a rapid rate of proliferation, like embryonic stem cells, adult stem cells, myosattelite cells, or myoblasts.

The cells are placed into a nutrient-rich solution, called a growth medium, in a controlled cultivator. This causes the stem cells to act as they would if they were still in the animals body to multiply, ideally quickly and into high densities.

The result is an edible product that looks, cooks, and tastes like animal meat because, biologically, it is animal meat. The major difference is that an animal does not need to be killed to make it.

Lab-grown meat is meat, meaning it is not vegan. However, the concept may create a loophole for some due to the fact that it can be made without the slaughter of animals.

Not all lab-grown meat production is free from animal use. Dutch scientist Mark Post, who presented the worlds first lab-grown burger at a press conference in 2013, grew cells in an animal-based broth to make his clean meat patty.

He said the most efficient method of cellular agriculture involves the slaughter of animals. Eventually my vision is that you have a limited herd of donor animals in the world that you keep in stock and that you get your cells from there, Post told The Telegraph.

Fetal bovine serum (FBS) poses an issue for vegans interested in lab-grown meat. FBS comes from the blood of a cow fetus and its the most widely used serum-supplement in the industry for eukaryotic cells.

However, some producers, like food tech company JUST, make a point of keeping the entire process cruelty-free. In a video, JUST shows how it developed its lab-grown chicken. For those very first cells, it was important to us how we got those cells, not just that we got the cells, JUST said. We came up with the idea to use one feather from the single best chicken that we could find.

The team waited for the chicken, whose name is Ian, to naturally drop a feather. The researchers then collected cells from this feather, enabling Ian to live on unharmed, but significantly important to the cause. The JUST team feasted on real chicken nuggets while Ian wandered around their feet, alive and well.

Ryan Bethencourt co-founder of the worlds leading life science accelerator, IndieBio believes lab-grown meat can bridge the gap between peoples hunger for meat and their desire to do less harm. The aim is to ensure that people keep eating what they love, but to produce it in a way so its not damaging the planet, Bethencourt, who is a vegan, said to the Guardian.

Conventional meat comes with its risks. In 2015, the World Health Organization (WHO) named red meat a Group 2 carcinogen, meaning it probably causes cancer in humans. WHO placed processed meat like bacon in the Group 1 category, meaning it is carcinogenic to humans. Asbestos and tobacco smoking are also in this category.

Post believes lab-grown meat could be safer for consumption than traditional meat. The creator of the first clean meat burger said to The Atlantic, We gain greater control over what the meat consists of, for example, its fat content.

And the reduction in the number of farmed animals reduces the chance of zoonosis, he added, referring to infectious diseases that can be passed from animals to humans.

JUST holds a similar view. It said in its video, One of the biggest points of comparison between what were doing and the old way of doing things is food safety.

JUSTs video displays a list of the risks associated with conventional meat, including salmonella, swine flu, giardia, fecal contamination, campylobacter, mad cow disease, foot-and-mouth disease, and avian chlamydiosis. It points out that clean meat carries none of these risks. And when you make that comparison, the difference is staggering, the company says.

Physician Neal Barnard, founding president of the Physicians Committee for Responsible Medicine (PCRM), believes lab-grown meat could be fortified to include extra nutrients like B12, in the same way vitamin D is added to orange juice.

The FDA and the USDA announced in March that they have established a framework to regulate clean meat. Its still in its preliminary stages but that hasnt curbed interest in the concept of clean meat. A study released by The Good Food Institute found that 66 percent of Americans are open to eating meat made in a lab.

Five food companies working within the cellular agriculture industry recently banded together to form the Alliance for Meat, Poultry & Seafood Innovation (AMPS Innovation).

AMPS Innovation aims to educate consumers and stakeholders about the industry and look at effective marketing for their products. The companies are also working with the government to establish a regulatory framework.

The founding members include Fork & Goode, JUST, and Memphis Meats, as well as cell-based seafood producers BlueNalu and Finless Foods. Representatives from these companies have met once a week for the last year to discuss obstacles faced by the industry.

The alliance has formed at an apt time, suggests Lou Cooperhouse, CEO of BlueNalu. This industry is maturing and is a lot more near-term than was thought of in the last year or in the past, Cooperhouse said in a statement. This is not something that is 10 years away. It is something that is short-term.

Lab-grown meat is not commercially available yet, but its launch may not be far off.

A recent report by global consultancy AT Kearney stated that by 2040, most of the meat people eat will not come from slaughtered animals. Sixty percent of meat will be either plant-based or cultivated in a lab.

The large-scale livestock industry is viewed by many as an unnecessary evil, the report said. With the advantages of novel vegan meat replacements and cultured meat over conventionally produced meat, it is only a matter of time before they capture a substantial market share.

It later added, Cultured meat will win in the long run.

Traditional animal agriculture leaves an undeniable mark on the planet. Its resource-intensive and generates huge amounts of greenhouse gas emissions. The United Nations Environment Programme (UNEP) named meat the worlds most urgent problem, saying that using animals for food has brought us to the verge of catastrophe.

The greenhouse gas footprint of animal agriculture rivals that that of everycar, truck, bus, ship, airplane, and rocket shipcombined, UNEP said. There is no pathway to achieve the Paris climate objectives without a massive decrease in the scale of animal agriculture.

Swapping to lab-grown meat could alleviate some of this damage. The CEO of Memphis Meats Uma Valeti said to the Guardian, If the US switched to Memphis Meats beef, we would expect the greenhouse gas reduction to be like taking almost 23m cars off the road. One burger could save the amount of water used in 51 showers.

Tim Noakesmith the founder of VOW, which is working on lab-grown kangaroo meat believes cell-based meat could help feed the worlds growing population. Its pretty insane, but its super important, its incredibly important, he said to Nine News. Weve reached the scale capacity in terms of creating food using traditional animal agriculture and we see that meat consumption is going to be rising and rising over coming decades.

VOW says its lab-grown kangaroo meat could be in supermarkets by the end of 2022. Its also speaking with top-tier chefs in Australia to explore the incorporation of its product into meals.

Other lab meat producers have similar goals. Japanese startup IntegriCulture Inc. wants to see its slaughter-free foie gras served in restaurants by 2021 and on the consumer market by 2023.

CEO of JUST Josh Tetrick took to Twitter in October to tease the launch of JUSTs lab-grown chicken nuggets. The company hasnt announced concrete plans, but Tetrick took the cruelty-free nuggets to the UK in January so that English TV presenter Helen Skelton-Myler could taste-test them. Tetrick explained, It is a nugget that didnt require killing a chicken and thats the way all meat should be. We dont need to choose between veggie burgers and a real burger.

Even the meat industry is clocking on to the notion. Agricultural giant Cargill invested in lab-grown meat company Aleph Farms earlier this year. Cargill, which controls more than 20 percent of Americas domestic meat market, has also invested in Memphis Meats.

Major meat producer Tyson Foods has also invested in Memphis Meats. Its also an investor in Israeli clean meat startup Future Meat Technologies. Justin Whitmore, Executive Vice President, Corporate Strategy and Chief Sustainability Officer of Tyson Foods, spoke about the move at a panel event in 2018. We dont want to be disrupted, he said.We want to be part of the disruption.

Summary

Article Name

What Is Lab Meat and Is It Vegan?

Description

Cultured meat -- also called lab-grown, cell-based, and clean meat -- could be available as soon as 2021. But what is lab meat? And is lab meat vegan?

Author

Jemima Webber

Publisher Name

LIVEKINDLY

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What Is Lab Meat and Is It Vegan? - LIVEKINDLY

Blood vessels are the lifeline of any organ.

The dense web of channels, spread across tissues like a spider web, allow oxygen and nutrients to reach the deepest cores of our hearts, brains, and lungs. Without a viable blood supply, tissues rot from the inside. For any attempt at 3D printing viable organs, scientists have to tackle the problem of embedding millions of delicate blood vessels throughout their creation.

Its a hideously hard problem. Although blood vessels generally resemble tree-like branches, their distribution, quantity, size, and specific structure vastly differs between people. So far, the easiest approach is to wash out cells from donated organs and repopulate the structure with recipient cellsa method that lowers immunorejection after transplant. Unfortunately, this approach still requires donor organs, and with 20 people in the US dying every day waiting for an organ transplant, its not a great solution.

This week, a team from Harvard University took a stab at the impossible. Rather than printing an entire organ, they took a Lego-block-like approach, making organ building blocks (OBBs) with remarkably high density of patient cells, and assembled the blocks into a living environment. From there, they injected a sacrificial ink into the proto-tissue. Similar to pottery clay, the ink hardens upon curingleaving a dense, interconnected 3D network of channels for blood to run through.

As a proof of concept, the team printed heart tissue using the strategy. Once the block fused, the lab-made chunk of heart could beat in synchrony and remained healthy for at least a week.

The technology, SWIFT (an eyebrow-raising backcronym of sacrificial writing into functional tissue), is a creative push into a new generation of 3D biofabrication. Although OBBs have been around, the team explained, little attention was previously paid to putting the Lego pieces together with blood vessels.

This is an entirely new paradigm for tissue fabrication, said study author Dr. Mark Skylar-Scott. The focus is on vessels, which will support 3D printed living tissue that may eventually be used to repair damaged parts of a natural body, or even replace entire human organs with lab-grown versions, he added.

[Its] beautiful work, commented tissue engineer Dr. Jordan Miller at Rice University, who was not involved in the study.

SWIFT straddles two wildly diverse fields across centuries: organoids and 15th-century lost-wax sculpturing.

Youve heard of organoids. Often dubbed mini-organs, these lentil-sized blobs of tissue remarkably mimic particular aspects of entire organsbrain organoids, for example, show the characteristic nerve cell types of firings of a preemie baby. The cellular inhabitants that make up organoids are what especially caught the teams attention: most are grown from induced pluripotent stem cells (iPSCs), which are often skin cells de-aged in a way that they can develop into almost any cell type with a little chemical prodding.

Because organoids are built from a patients own cells, theyre completely compatible with the host for an immune standpoint. That particular strength caught the teams attention: organoids, they reasoned, make the ideal OBBor Lego piecesto biomanufacture patient- and organ-specific tissues with all the desired properties.

For example, the team explained, organoids are packed with a high density of cells, which is usually hard to achieve with traditional 3D tissue printing. Under the right conditions, they also develop similarly to real organs in terms of cellular composition and microarchitecture to support functionfor about a year. Without a blood vessel network, all organoids die.

Heres where lost-wax technique comes in.

First, a very brief explainer. Throughout the Renaissance, the majority of Italian sculptors used the technique to fabricate bronze statues. In the simplest method, a statuette is first modeled in beeswax and covered in potters clay. Once dried, the assembly is heatedthe clay is fired into ceramics, and the wax melts and flows away (hence, lost). Once cooled, the entire project is now a hollow ceramic mold, through which the artist can pour in molten metal.

Now, replace beeswax with sacrificial bio-ink, and thats pretty much how SWIFT carves out its intricate tunnels of blood vessels.

The entire fabrication process is two main steps. The team first grew hundreds of thousands of proto-organoids inside culture dishes. These tiny blobs are so small they dont yet need to be churned inside a bioreactor, but theyre mightily packed with roughly 200 million cells every milliliterabout the bottom bit of a teaspoon. These make up the techniques building blocks, or OBBs.

Next, roughly 400,000 OBBs are mixed with a dense, gel-like liquid with the consistency of mayonnaise at a low temperature. The liquid is filled with collagen, a protein that keeps our skin elastic, and other synthetic versions. The OBBs are now somewhat suspended inside the gel-like matrix, which is ideally suited for creating vascular channels, the team said. Altogether, the organoids and gel are compacted into a density similar to human tissue, making up the raw material for further sculpting.

Now the fun second step. Using a 3D printer, the team moved a tiny nozzle containing both harmless red ink and gelatin into the mixture, depositing both in a pre-programmed manner. In this way, the team was able to draw intricate branch-like patterns into the organoid-gel mixture. Similar to squeezing frosting out of a bag, the team was able to adjust the diameter of the gelatin ink by nearly two-fold, mimicking the usual structure of blood vesselsthick main channels that increasingly become tinier.

Once the network was fully printed, they then gently heated the mixture to body temperature. The matrix stiffens, and the gelatin inkacting like Jello left under the sun for too longmelts and is washed away. What remains is a network of OBBS, or organoids, linked with a vascular structure that can now be filled with blood.

As a proof of concept, the team went straight for the heartcardiac tissue, that is. They repeated the steps using heart-derived cells, and kept the resulting chunk of heart, a little bigger than half an inch inside a chamber, filled with a nutritious, oxygen-rich bath.

Within a week, individual organoids embedded inside the gel fused together into a collective: the tissue was able to contract almost 50 percent better than immediately after printing, and the beating rhythm synchronized, suggesting that the lab-grown tissue had further matured.

The tissue even reacted similarly to a normal heart. When the team infused a drug that increases heart rate into those printed vessels, the tissue doubled in its heartbeat. Similarly, drugs that normally decrease heart muscle contraction also worked on the mini-heart. As a final proof of concept demo, the team printed a chunk of heart tissue with a branch of the coronary arterya main blood vessel branch that normally wraps the heart.

The new study is hardly the first try at printing organs with blood vessels. Miller, for example, biomanufactured a hydrogel that mimicked a lung air sac earlier this May. Layer by layer, the precise anatomy of the lung-mimicking structure is constructed with liquid hydrogel, and solidified using light.

The new study stands out in its sheer creativity. By combining organoids with an ancient sculpture technique, the team was able to pack far more cells into the resulting structure, while tapping into the natural mini-organization that stems from organoids. The results arent just promising for printing larger, more intricate human organs with a blood supplythey could also help inform organoid research, which has struggled to keep the pseudo-organs alive.

The team is planning to transplant their SWIFT tissue into animals to further examine their function and health. But to the team, the main goal is to finally bring 3D-printed organs to people desperately on the transplant waiting list.

Our method opens new avenues for creating personalized organ-specific tissues with embedded vascular channels for therapeutic applications, they said.

Image Credit: Wyss Institute at Harvard University / CC BY-NC-ND 4.0

Read more from the original source:
How a Centuries-Old Sculpting Method Is Helping 3D Print Organs With Blood Vessels - Singularity Hub