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SAN FRANCISCO and KYOTO, Japan, April 18, 2024 /PRNewswire/ -- Shinobi Therapeutics, a biotechnology company developing a new class of immune evasive iPS cell therapies, today announced a partnership with Panasonic Holdings Corp and Kyoto University's Center for iPS Cell Research and Application (CiRA). Through this strategic collaboration, the organizations aim to engineer a novel manufacturing platform to produce iPS-T cell therapies more efficiently and at lower cost than is possible with currently available technology.

"To make promising iPS-T cell therapies accessible to the broader population, Panasonic is committed to developing a manufacturing platform that will produce safe cells for therapies at the lowest possible cost," said Yuki Kusumi, Representative Director and President of Panasonic Holdings Corporation. "Reducing the production time and cost of cell therapies must be done in a manner that does not compromise safety or efficacy, and we are thrilled to see the Japanese biotech and engineering communities coming together to make that happen."

Cell therapies have shown remarkable promise in treating blood cancers and other intractable diseases, but manufacturing costs render these therapies inaccessible to many patients around the world. Shinobi's iPS-T cell technology, built upon a decade's worth of iPSC research pioneered at CiRA by Shinobi co-founder Shin Kaneko using iPSCs originally created by Nobel laureate Shinya Yamanaka, will be used to support the creation of a closed-system manufacturing device created by Panasonic, opening up an entirely new paradigm for cell therapy production.

"Advancements in iPS cell production and Shinobi's genetic modification of iPSCs for immune evasion have made regenerative T cell therapy increasingly feasible," said Shin Kaneko, Co-Founder at Shinobi. "The automated cultivation device developed in this joint research will significantly accelerate this, contributing to the realization of a world where state-of-the-art regenerative killer T cell therapy can be provided for every patient."

The newly announced partnership will leverage Panasonic's manufacturing expertise to develop a new method of producing iPS-T cell therapies in a closed-system process. The first phase of the partnership will be completed in April 2025, when the companies expect to release the initial prototype.

"While cell therapies have the potential to transform patient care across a wide range of intractable diseases, we have a long road ahead to overcome the challenges in manufacturability and accessibility," said Dan Kemp, CEO at Shinobi. "We are fortunate to be working with the most renowned partners across the academic and industry landscape as we endeavor to put cell therapies within reach for all patients who need them."

About Shinobi TherapeuticsShinobi Therapeutics is a biotechnology company developing a new class of off-the-shelf immune evasive iPSC-derived cell therapies. Based on the research of scientific co-founders Shin Kaneko, M.D., Ph.D., at Kyoto University and Tobias Deuse, M.D., at University of California, San Francisco, Shinobi has created a new allogeneic CD8a iPS-T cell platform that demonstrates comprehensive immune evasion from all arms of the immune system. For more information, please visit http://www.shinobitx.com.

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Panasonic and Shinobi Therapeutics Partner to Develop Efficient and Cost-Effective iPS Cell Therapy Manufacturing ... - PR Newswire

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Sixty years ago this month, on April 22, 1964, the New York Worlds Fair opened in Flushing MeadowsCorona Park in Queens, New York. The Fair had the theme of Peace Through Understanding, and was dedicated to Mans Achievement on a Shrinking Globe in an Expanding Universe, as symbolized by the 140-foot-tall stainless-steel globe, known as the Unisphere, that towered over a massive reflecting pool.

The 1964 Worlds Fair wasnt the first one held in Flushing Meadows; the Unisphere was built on the same ground once occupied by the similarly spherical Perisphere, which was constructed for the 1939 Worlds Fair. To kick off the 1964 Fair, President Lyndon B. Johnson delivered opening remarks that evoked the 39 edition, which imagined the 1960s of the future:

But Johnsons reflections on human progress werent all positive. No one prophesied that half the world would be devastated by war, or that millions of helpless would be slaughtered, the President noted, just months after he approved the controversial National Security Action Memorandum 288 escalating the U.S.s involvement in the Vietnam War. No one foresaw power that was capable of destroying man, or a cold war which could bring conflict to every continent.

Overhead view of the 1964 Worlds Fair, showing the Unisphere and surrounding pavilions in Flushing Meadows-Corona Park in Queens, New York.

Johnsons presence at the 1964 Worlds Fair underscored the somber reality facing America at the time. After all, an assassins bullet killed the intended speaker, his predecessor, John F. Kennedy, thrusting hima representative of Washington D.C.s old guardinto the role intended for JFK, a symbol of the New Frontier.

So, who could Fair attendees turn to for hopeful visions of Peace Through Understanding, and Mans Achievement on a Shrinking Globe? Only one man: Walt Disney.

Disney, who had been a weekly presence in American homes for the last decade through his television show, Walt Disneys Disneylandlater titled Walt Disney Presentscreated four attractions for the 64 Worlds Fair. These exhibits were a hit, drawing 135,000 visitors per day during the first season alone, according to The Walt Disney Family Museum.

Walt Disney at the 1964 New York Worlds Fair

Visitors line up to enter Its A Small World at the Worlds Fair in 1965.

Disneys attractions included Great Moments with Mr. Lincoln at the Illinois Pavilion, an animatronic replica of another President who represented hope, and who was also assassinated; Fords Magic Skyway for the Ford Motor Company, where guests rode in Ford vehicles past animatronic dinosaurs; and the now-iconic its a small world, which Disneys Imagineers built in collaboration with Pepsi-Cola as a tribute to UNICEF.

But it was the Carousel of Progress, located in General Electrics Progressland pavilion, that most epitomized Walt Disneys vision of the future. The rotating animatronic show guided audiences through the history of human innovation and provided a comforting escape with its optimistic theme song by the Sherman Brothers, promising, Theres a great, big, beautiful tomorrow/Shining at the end of every day.

In the aftermath of a national tragedy, Walt Disney became a beacon of optimism for fairgoers, and for Americans. His presence fostered a belief in a great big beautiful tomorrow.

Perhaps its that enduring optimism that fuels the persistent conspiracy that Disney, who died in 1966, might still be among us, secretly preserved in hopes of one day being revived.

In 1964, besides contributing to the Worlds Fair, Disney also released his most acclaimed live-action film yet: Mary Poppins. Just a few years earlier, during a screening of To Kill a Mockingbird, Disney had reportedly lamented, Thats the kind of film Id like to make, but I cant. Now, his tender musical adaptation of P.L. Travers novel had achieved the same milestone as Universals adaptation of Harper Lees seminal work: a nomination for Best Picture at the Academy Awards.

Poster for Mary Poppins, touting the film as "Walt Disney's Greatest Achievement."

With his status finally solidified in the entertainment industry, Disney turned his sights to the futurenot of his film studio, but of humanity. Intent on using his renowned imagination to forge a brighter tomorrow, Disney envisioned a utopia designed to last forever. In 1964, the future looked bright for Walt Disney.

In less than three years, he would be dead.

On December 15, 1966, Walt Disney died as a result of complications from lung cancer. As Biography notes, a private funeral was held the next day, and on December 17, his body was cremated and interred at Forest Lawn Memorial Park in Glendale, California.

Some conspiracy theorists, however, believe that Disneys remains arent actually at Forest Lawn. Theyll tell you, according to Biography, that Disneys body is instead suspended in a frozen state and buried deep beneath the Pirates of the Caribbean ride at Disneyland in Anaheim, California, awaiting the day when medical technology would be advanced enough to reanimate the animator.

The rumored cryonic freezing of Walt Disney has no clear origin point that Biography could confirm. But its first documented mention is in a 1969 Ici Paris article, reportedly as a prank concocted by disgruntled animators who once worked for Disney seeking to have a laugh at their late taskmasker employers expense. Their motive was seemingly revenge for Disneys strict oversight, an aftermath of a labor uprising in the late 1930s that is chronicled in depth in The Disney Revolt: The Great Labor War of Animations Golden Age.

Initially, whispers suggested Disneys entire body was preserved in a secret facility, but soon the tale focused on the animators head alone, frozen beneath iconic Disneyland attractions like Pirates of the Caribbean, the Matterhorn, the Partners statue at the center of the park, and even the Magic Kingdom castle. Over time, it seems every corner of Disneyland has been rumored to shelter its founders frozen head.

The notion of Walt Disneys icy remains hiding within park attractions might stem from the actualsecrets of Disneyland. There is indeed a hidden space at the top of the Matterhorn, but its home to a basketball court for bored Disney staff, not a frozen former CEO. And while early versions of Pirates of the Caribbean did feature real skeletons from UCLAs medical school, according to SFGate, none belonged to Disney himself.

The grim idea that only Walt Disneys head was placed in cryostasis might have caught on due to its eerie, sci-fi feel, with modern cryonics offering both full-body and head-only preservation options. That singular detail adds a creepy wrinkle to the conspiracy, evoking images more akin to the 1962 horror flick The Brain That Wouldnt Die than the reality of a Hollywood moguls legacy.

Nevertheless, the tale of Walt Disneys frozen head persisted, specifically resurfacing in two biographies released years after his death: Leonard Moselys 1986 Disneys World and Marc Eliots 1993 Walt Disney: Hollywoods Dark Prince, which further embedded the legend into popular culture.

Eliots controversial biography, which was criticized by Disneys family and historians alike for its speculative content, included unfounded allegations against Disney, including claims that he was an FBI informant (which evidence suggests he was not), and that he refused to have flags at half mast at Disneyland when JFK died (which photographic evidence disproves). Nevertheless, Hollywoods Dark Prince fed into a desire to find the dark side of a man often propped up as the symbol of Americana, pushing both the cryonics rumor and the assertions of Disneys rampant antisemitism (also notably debunked) into the mainstream.

Disneys family has firmly denied the rumor that he was cryogenically frozen, and as Biography points out, it has been further discredited by those pointing to the existence of signed legal documents that indicate Disney was in fact cremated and that his remains are interred in a marked plot (for which his estate paid $40,000) at Forest Lawn, the exact location of which is a matter of public record. Plus, the first instance of a person being cryopreserved after his death, James Bedford, didnt occur until nearly a month after Disneys cremation, debunking the timeline of the rumor that Disney was frozen.

Walt Disneys grave site at Forest Lawn Memorial Park in Glendale, California.

Diane Disney, Walts daughter, wrote in a 1972 biography about her famous father that she doubted her father had even heard of cryonics.

Nonetheless, even skeptics who reject the frozen head story might concede that Walt Disney, a famously forward-thinking futurist, could have been aware of cryonics. The concept gained attention in 1964, the same year Disney shifted his focus from film to envisioning his utopian future.

If you were browsing the New Releases shelf at a bookstore in 1964, you might stumble upon an intriguing non-fiction book in between copies of Ernest Hemingways A Moveable Feast and the Warren Commissions The Warren Report: Robert Ettingers The Prospect of Immortality.

Most of us now living have a chance for personal, physical immortality, Ettinger claims in the very first sentence. All you need to do, Ettinger says, is join one established fact with one reasonable assumption.

The fact: At very low temperatures it is possible, right now, to preserve dead people with essentially no deterioration, indefinitely.

The assumption: If civilization endures, medical science should eventually be able to repair almost any damage to the human body, including freezing damage and senile debility or other cause of death.

Six decades later, while we havent mastered the art of repairing all human body damage, our cryopreservation methods have advanced significantly, particularly with the introduction of vitrification by Greg Fahy and William F. Rall in the 1980s. And recent scientific advancements suggest that what we currently understand as death might be more reversible than previously thought.

Some excerpts from Ettingers book resonate with the futuristic optimism of Walt Disneys Tomorrowland. For example, Ettinger writes,If civilization endures ... if the Golden Age materializes, the future will reveal a wonderful world indeed, a vista to excite the mind and thrill the heart. However, even if Disney had encountered Ettingers work, his imagination had already been sparked by another piece of literature before he died.

In May 1960, Horizon magazine published Out of a Fair, a City, an article in which architect Victor Gruen envisioned transforming the 1964 Worlds Fair site into a domed city to test solutions for societal challenges. According to Imagineer Marty Sklars 1999 book, Remembering Walt, Gruens philosophy (further elaborated in Gruens 1964 work, The Heart of our Cities: The Urban Crisis, Diagnosis and Cure,) was a significant influence on Disney during his final yearsso much that he began an ambitious plan to build a community in Florida that would never cease to be a living blueprint of the future.

Disney, utilizing land his corporation discreetly bought in Florida, set out to build an Experimental Prototype Community of Tomorrow adjacent to his planned East Coast theme park. The community aimed to eliminate traffic jams, offer abundant green spaces, and showcase efficient public transportation with the use of a monorail system.

EPCOT world showcase at Walt Disney World Resort, 1982

After Walt Disneys death, the Florida land earmarked for his future city was transformed into EPCOT, the second theme park at Walt Disney World Resort. EPCOT features a Future World section with educational attractions and a World Showcase with international pavilions, operating as a perpetual Worlds Fair.

In his last years, Walt Disney was introspective, focusing not on the prospect of immortality, but on a different sentiment. While the 1964 song Great Big Beautiful Tomorrow planted the seed in millions of young minds, it was another tune by the Sherman Brothers from the same year that resonated deeply with Disney as he reflected on his life. Richard Sherman recalls:

There is little left of the 1964 New York Worlds Fair in Flushing MeadowsCorona Park. The spot where the Carousel of Progress once played in GEs Progressland is now an athletic field. The Vatican pavilion has been replaced by a stone bench. The Unisphere, however, still remains, towering over a park whose occupants have little memory, or even awareness, of the Great Big Beautiful Tomorrow promised at the park 60 years ago.

The Unisphere in Flushing Meadows-Corona Park in March 2024.

For the Baby Boomers who experienced Disneys contributions to the 1964 Worlds Fair, the event offered hope and a last optimistic vision of the future from Uncle Walt. And while today, these visitors can encounter preserved pieces of the Fair at the Queens Museum and experience its a small world at Disney parks worldwide, they cant turn that athletic field back into Progressland. And they cant bring back the man who made it possible.

Walt Disney and Mickey Mouse at the Rose Parade in 1966.

Walt Disneys legacy extends far beyond his films and theme parks. He symbolizes something greater than a sprawling entertainment empire. As biographer Neal Gabler put it in the final pages of Walt Disney: The Triumph of the American Imagination, he demonstrated how one could assert ones will on the world at the very time when everything seemed to be growing beyond control and beyond comprehension.

For conspiracy theorists who want to believe Walt Disney is a frozen head, waiting for revival, perhaps its because they want to believe he asserted his will over the one thing no one has been able to do before. That maybe, if the Golden Age materializes, Walt Disney could even come back to life. And with him would come, once again, the promise of a Great Big Beautiful Tomorrow. A promise he made in Queens 60 years ago.

Michael Natale is the news editor for Best Products, covering a wide range of topics like gifting, lifestyle, pop culture, and more. He has covered pop culture and commerce professionally for over a decade. His past journalistic writing can be found on sites such as Yahoo! and Comic Book Resources, his podcast appearances can be found wherever you get your podcasts, and his fiction cant be found anywhere, because its not particularly good.

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The Truth About Walt Disney's Frozen Head and His Quest to Live Forever - Popular Mechanics

Susan G. Komen Commends Bill Introduction; Urges Quick Passage

ST. PAUL, Minn., March 28, 2024 /PRNewswire/ --Susan G. Komen, the world's leading breast cancer organization, applauds Representative Patty Acomb (D-Minnetonka) for introducing legislation that would eliminate financial barriers to clinically appropriate genetic testing, as well as the recommended screenings based on the results of that testing.

In Minnesota, more than 5,480 people will be diagnosed with breast cancer and 630 are expected to die of the disease in 2024 alone. In the U.S., 5-10% of breast cancers are related to a known inherited gene mutation. The lifetime risk of breast cancer increases 20-49% for women with moderate risk inherited gene mutations and 50% or more for women with high-risk inherited gene mutations.

HF 5050, introduced by Rep Acomb, eliminates the patient out-of-pocket costs for multi-gene panel testing for inherited gene mutations and evidence-based screenings, ensuring individuals have access to critical information regarding their lifetime cancer risk and recommended early detection and cancer surveillance.

"Passage of this legislation will allow patients to better understand their lifetime cancer risk and access to needed risk reduction and treatment strategies," said Molly Guthrie, Vice President of Policy and Advocacy at Susan G. Komen. "Individuals should have all information needed to make informed decisions about their healthcare without burdensome financial barriers."

Germline testing is a type of test that looks for inherited mutations that have been present in every cell of the body since birth. These tests are conducted via the collection and analysis of blood, saliva or cheek cells. Identification of inherited cancer risk can help guide decisions regarding recommended screenings for the early detection of cancer, personalized cancer treatments and risk-reducing medical treatments.

Studies have shown an estimated 83 percent of eligible patients that underwent multigene panel testing had changes to their medical management, including modifications in follow-up and chemotherapy strategy.

"This legislation will ensure patients have equitable access to information concerning their lifetime risk of cancer, allowing them to make key decisions regarding risk reducing strategies and recommended screenings for early detection," said Rep. Patty Acomb.

According to a 2020 American Association for Cancer Research Report, 65% of young white women with breast cancer were offered genetic testing, while only 36% of young Black women with breast cancer were offered the same test options. Additional studies show that minority patients were more likely to utilize genetic testing following a cancer diagnosis but less likely following a family history of cancer, resulting in a missed opportunity for mutation detection and cancer prevention for these patients.

About Susan G. KomenSusan G. Komen is the world's leading nonprofit breast cancer organization, working to save lives and end breast cancer forever. Komen has an unmatched, comprehensive 360-degree approach to fighting this disease across all fronts and supporting millions of people in the U.S. and in countries worldwide.We advocate for patients, drive research breakthroughs, improve access to high-quality care, offer direct patient support and empower people with trustworthy information. Founded by Nancy G. Brinker, who promised her sister, Susan G. Komen, that she would end the disease that claimed Suzy's life, Komen remains committed to supporting those affected by breast cancer today, while tirelessly searching for tomorrow's cures. Visit komen.org or call 1-877 GO KOMEN. Connect with us on social at http://www.komen.org/contact-us/follow-us/.

CONTACT: Amanda DeBard Susan G. Komen (972) 701-2131 [emailprotected]

SOURCE Susan G. Komen for the Cure

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Bill Introduced in Minnesota Would Increase Access To Genetic Testing - PR Newswire