Posts Tagged ‘industry’

Greater use of CRISPR-based therapies in clinical trials is expected to drive further advancements in precision medicine, GlobalData states.

There has been a notable rise in licensing agreements for innovator drugs incorporating clustered regularly interspaced short palindromic repeats (CRISPR)-based technology for gene therapies over the past five years, according to data and analytics firm GlobalData.

These agreements have amassed a total deal value of $21 billion. Of note, between 2020 to 2022, there was a remarkable surge in deal worth. For agreements relating to or involving treatments for haematological disorders, the total deal value reached $1.8 billion, the research found.

For instance, the approval of Casgevy in the US in December 2023 signified a breakthrough in gene therapy. Vertex Pharmaceuticals treatment was subsequently the first CRISPR/Cas9 gene-edited therapy to be granted a marketing authorisation by the European Commission (EC) in February 2024.

Innovator drugs harnessing CRISPR technologies saw 182 percent growth in total licensing agreement deal value from $5.6 billion in 2020 to $15.8 billion in 2022. Among the top three therapy areas, oncology represented over half of the total deal value with $11.9 billion, followed by immunology with $6.7 billion, and central nervous system with $2.2 billion, Ophelia Chan, Business Fundamentals Analyst at GlobalData explained.

GlobalData highlighted that the largest CRISPR-based deal of 2023 was Eli Lilys subsidiary, Prevail Therapeutics gaining rights to Scribe Therapeuticss CRISPR X-Editing (XE) technologies. In a deal potentially worth over $1.57 billion, the agreement seeks to advance in vivotherapies for targets that cause serious neurological and neuromuscular diseases.

The increasing presence of CRISPR-based therapies in clinical trials is anticipated to fuel further advancements in precision medicine

CRISPR technology is transforming targeted gene therapies for diverse unmet diseases by precisely targeting diverse genomic sites, promising tailored treatments and improved patient outcomes. The increasing presence of CRISPR-based therapies in clinical trials is anticipated to fuel further advancements in precision medicine, Chan stated.

In other recent gene therapy news, last month the US Food and Drug Administration (FDA) authorised Lenmeldy (atidarsagene autotemcel) for children with early-onset metachromatic leukodystrophy (MLD).

Anti-Cancer Therapeutics, Big Pharma, Biopharmaceuticals, business news, Clinical Development, Clinical Trials, Data Analysis, Drug Development, Drug Markets, Drug Safety, Gene therapy, Industry Insight, Research & Development (R&D), Technology, Therapeutics

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CRISPR technologies fuelling haematological innovations - European Pharmaceutical Review

Fort Lauderdale, FL, April 09, 2024 (GLOBE NEWSWIRE) -- The adage age is just a number embodies feeling young at any age. So whats more important when it comes to healthy aging: brain or brawn? In a recent survey of 4,100 Life Extension customers, 68% of whom were aged 61 or older, more than half ranked mental performance as the most important factor for feeling young for their age, while physical health came in a distant second place at 24%. To help people stay ahead of the aging game, Life Extension has launched Healthy Aging Powder, a triple-nutrient blend of taurine for cardiovascular health, lithium for a healthy mood, and spermidine from wheat germ extract to promote memory health. February 2024 survey of Life Extension customers.

We wanted to offer customers a way to promote a healthy aging process, so we focused on finding nutrients that support three cornerstones of aging gracefully: memory and mood health and a healthy heart, explained Life Extensions Vice President of Product Development, Glenn MacEachern, MBA.

According to Michael A. Smith, MD, Life Extensions Director of Education, aging healthily goes beyond flexing strong muscles; it also depends on heart health and, yes, cognition. Physical health is a no-brainer when it comes to healthy aging, but many dont realize that maintaining cognitive health and performance, including a healthy mood, is also crucial, Dr. Smith said. Weve come to accept our working memory slowing down and our mood souring as the norm. But we dont have to take age-related cognitive decline for granted. By tweaking our lifestyle, we can support memory health and maintain a healthy mood at every age.

Dr. Smith recommends choosing a dietary supplement that addresses the trifecta of healthy agingmemory and mood health, and a healthy heartas a proactive way to make those later years truly golden.

Healthy Aging Powder is a new addition to Life Extensions longevity supplements line, which also includes Optimized Resveratrol Elite to help protect against oxidative stress and NAD+ Cell Regenerator to support healthy cellular energy pathways. The easy-mix, unflavored powder blend contains no genetically modified ingredients.

About Life Extension For more than 40 years, Life Extension has pursued innovative advances in health, conducting rigorous clinical trials and setting some of the most demanding standards in the industry to offer a full range of quality vitamins and nutritional supplements and blood-testing services. Life Extensions Wellness Specialists provide personalized counsel to help customers choose the right products for optimal health,nutritionand personal care. To learn more, visit LifeExtension.com.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Mental Performance Is the #1 Factor for Healthy Aging, According to Life Extension Survey - GlobeNewswire