Vaccine with no jab: Protein vaccines for needle-free immunization through the skin

Posted: April 4, 2010 at 8:11 am

Story Summary: There are a few protein drugs that can currently be applied through the skin, but their production remains complex and expensive. Thus, his team has developed a short peptide, the low molecular weight protamine (LMWP) that is able to pass through cell membranes into the interior of cells. LMWP peptidescan be produced quickly, easily, and inexpensively in large amounts from the protein protamine. Protamine is a pharmaceutical agent, given to treat hemorrhages that occur after treatment with heparin or elevated levels of heparincaused by disease. The researchers were able to demonstrate this with various test proteins, linked to the LMPW, that were also labeled with a fluorescence dye. Particular accumulation of the proteins was observed in the epidermis. Activation of the immune system in mice was observed that was equivalent to that elicited by conventional immunization. Our skin is not just our primary protection against infections because it presents a physical barrier; our epidermis is also rich in Langerhans cells, which participate in triggering an immune response. Therefore, it may be favorable for an immunization if the vaccine accumulates in the epidermis. One particularly interesting aspect of this new non-invasive method is that the boosters required for many vaccination protocols could be administered by the patients themselves. This could increase the success of vaccination campaigns in poor and remote regions of the world, where medical facilities are scarce. The idea is that following administration of a DNA vaccine, the body converts the information in the DNA vaccine into a protein . . . In a paper published on April 24, 2008 in the journal Vaccine, a Massachusettss biotechnology company, Cure L . . . If successful, the universal flu injection would transform the way we vaccinate against . . . If successful, the universal flu injection would transform the way we vaccinate against . . . The book gave one equation and I (thinking back to chemistry) got another. They both had the same. water and plasma!!!Mar 30, 2010 Hello, Recently i was into chem books and read about this plasma matter. water and plasma!!!Mar 30, 2010 Hello, Recently i was into chem books and read about this plasma matter. water and plasma!!!Mar 30, 2010 Hello, Recently i was into chem books and read about this plasma matter. So now i know plasma matter is in the sun and all stars and also in the humble candle flame. What i wanna know is whether. What i wanna know is whether. What i wanna know is whether. (PhysOrg. (PhysOrg. (PhysOrg. com) — Amino acids are markers for potential life since they are the building blocks of proteins. com) — Amino acids are markers for potential life since they are the building blocks of proteins. com) — Amino acids are markers for potential life since they are the building blocks of proteins. 2 hours ago | not rated yet | 0 By mixing and matching choices from a buffet of 30 to 70 options, scientists are modeling waters behavior in surface and subsurface reactions and in heterogeneous atmospheric processes such as the formation . . . 23 hours ago | / 5 (1) | Scientists in Brazil are reporting for the first time that coffee beans contain proteins that can kill insects and might be developed into new insecticides for protecting food crops against destructive pests. 23 hours ago | / 5 (1) | Scientists in Brazil are reporting for the first time that coffee beans contain proteins that can kill insects and might be developed into new insecticides for protecting food crops against destructive pests….Read the Full Story

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