Selected Update: Innate immunity: Detailed detection

Posted: April 14, 2010 at 8:15 am

Story Summary: Innate immunity: Detailed detectionTwo recent papers have revealed further details of how RNA viruses engage the host innate immune system. Two recent papers have revealed further details of how RNA viruses such as West Nile virus (WNV) and influenza virus engage the host innate immune system. Recognition of RNA virus infection by pattern recognition receptors (PRRs) triggers an antiviral signalling cascade that culminates in the induction of type I interferons (IFNs) and a proinflammatory response. Progression of the infection was followed, and the authors found that IPS1 is involved in restricting the tissue tropism of WNV and in the entry of this neurotropic virus into the central nervous system. Moreover, the numbers of circulating regulatory T cells, which can depress the inflammatory response, were decreased in the absence of IPS1. Sheilagh MolloyReferencesSuthar, M. S. et al. IPS-1 is essential for the control of West Nile virus infection and immunity….Read the Full Story

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