454 Sequencing Study Unravels the Hidden Genomic Complexity of the Giant Mimivirus

Posted: April 4, 2010 at 1:25 am

Story Summary: Previous studies have shown that unlike most viruses, the Mimivirus has more genes than many bacteria and performs functions that normally occur only in cellular organisms. The results of the most recent study, led by a team from the Structural and Genomic Information Laboratory at the Mediterranean Institute of Microbiology in Marseille, France, suggest that the Mimivirus is even more complex than previously thought. In a quest to fully characterize the Mimivirus transcriptome and obtain new insights into its gene and protein functions, the researchers turned to the Genome Sequencer FLX System. Sequence mapping also allowed the precise delineation of most promoter regions and the identification of the sequence motif governing the early versuslate expression of Mimivirus genes. We are pleased to see continued widespread adoption of 454 Sequencing systems in virology research, said Ulrich Schwoerer, Head of Global Marketing at 454 Life Sciences. We are excited to follow the teams continued work in this field. About RocheHeadquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the worlds largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roches personalised healthcare strategy aims at providing medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients. In 2009, Roche had over 80000 employees worldwide and invested almost 10 billion Swiss francs in R&D. The Group posted sales of 49. (1) Legendre et al. mRNA Deep Sequencing Reveals 75 New Genes and a Complex Transcriptional Landscape in Mimivirus. 454, 454 LIFE SCIENCES, 454 SEQUENCING, and GS FLX are trademarks of Roche….Read the Full Story

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